glioma

Summary

Summary: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Top Publications

  1. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  2. doi Malignant gliomas in adults
    Patrick Y Wen
    Division of Neuro Oncology, Department of Neurology, Dana Farber corrected Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 359:492-507. 2008
  3. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
  4. pmc IDH1 and IDH2 mutations in gliomas
    Hai Yan
    Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 360:765-73. 2009
  5. pmc IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    Sevin Turcan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 483:479-83. 2012
  6. ncbi Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group
    Patrick Y Wen
    Center for Neuro Oncology, Dana Farber Brigham and Women s Cancer Center, SW430D, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 28:1963-72. 2010
  7. pmc Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    Lenny Dang
    Agios Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    Nature 462:739-44. 2009
  8. pmc Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
    Rameen Beroukhim
    Broad Institute, Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:20007-12. 2007
  9. pmc Malignant glioma: lessons from genomics, mouse models, and stem cells
    Jian Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 149:36-47. 2012
  10. pmc K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    Dong Anh Khuong-Quang
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:439-47. 2012

Detail Information

Publications271 found, 100 shown here

  1. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance...
  2. doi Malignant gliomas in adults
    Patrick Y Wen
    Division of Neuro Oncology, Department of Neurology, Dana Farber corrected Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 359:492-507. 2008
  3. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
    ..A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively...
  4. pmc IDH1 and IDH2 mutations in gliomas
    Hai Yan
    Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 360:765-73. 2009
    A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors ..
  5. pmc IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    Sevin Turcan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 483:479-83. 2012
    ..b>Glioma CIMP (G-CIMP) is a powerful determinant of tumour pathogenicity, but the molecular basis of G-CIMP remains ..
  6. ncbi Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group
    Patrick Y Wen
    Center for Neuro Oncology, Dana Farber Brigham and Women s Cancer Center, SW430D, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 28:1963-72. 2010
    ..In this proposal, we present the recommendations for updated response criteria for high-grade gliomas...
  7. pmc Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    Lenny Dang
    Agios Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    Nature 462:739-44. 2009
    ..These data demonstrate that the IDH1 mutations result in production of the onco-metabolite 2HG, and indicate that the excess 2HG which accumulates in vivo contributes to the formation and malignant progression of gliomas...
  8. pmc Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
    Rameen Beroukhim
    Broad Institute, Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:20007-12. 2007
    ..half of these events correspond to known cancer-related genes, only some of which have been previously tied to glioma. We also show that superimposed broad and focal events may have different biological consequences...
  9. pmc Malignant glioma: lessons from genomics, mouse models, and stem cells
    Jian Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 149:36-47. 2012
    ..We discuss the controversies surrounding glioma stem cells and explore how the integration of new molecular data allows for the generation of more informative ..
  10. pmc K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    Dong Anh Khuong-Quang
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:439-47. 2012
    ..Based on prognostic and therapeutic implications, our findings argue for H3.3-mutation testing at diagnosis, which should be rapidly integrated into the clinical decision-making algorithm, particularly in atypical DIPG...
  11. pmc The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    Jason T Huse
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 23:1327-37. 2009
    ..central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. Research over the last two decades has revealed the particular importance of the Akt pathway, and its molecular ..
  12. ncbi Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    Shideng Bao
    Department of Surgery, Preston Robert Tisch Brain Tumor Center, Molecular Cancer Biology Program, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 66:7843-8. 2006
    ..We examined the potential of stem cell-like glioma cells (SCLGC) to support tumor angiogenesis...
  13. pmc Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    Wei Xu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Medical School, Fudan University, Shanghai 20032, China
    Cancer Cell 19:17-30. 2011
    ..In glioma, IDH1 mutations are associated with increased histone methylation and decreased 5-hydroxylmethylcytosine (5hmC)...
  14. ncbi Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    Steven M Pollard
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 4:568-80. 2009
    ..Here, we demonstrate routine and efficient derivation of adherent cell lines from malignant glioma that display stem cell properties and initiate high-grade gliomas following xenotransplantation...
  15. ncbi Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series ..
  16. ncbi Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
    Lixin Sun
    Neuro Oncology Branch, National Cancer Institute National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:287-300. 2006
    Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear...
  17. pmc The transcriptional network for mesenchymal transformation of brain tumours
    Maria Stella Carro
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 463:318-25. 2010
    ..A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma, but the regulatory programs responsible for implementing the associated molecular signature are largely unknown...
  18. ncbi MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2
    Xie Feng Wang
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, People s Republic of China
    J Cancer Res Clin Oncol 138:573-84. 2012
    Recently, several microRNAs (miRNAs) were reported to be involved in the modulation of glioma development...
  19. pmc Metabolic state of glioma stem cells and nontumorigenic cells
    Erina Vlashi
    Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:16062-7. 2011
    Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target for novel treatment approaches...
  20. ncbi Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
    Christian Hartmann
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg, Germany
    Acta Neuropathol 118:469-74. 2009
    ..In addition, patients with anaplastic glioma harboring IDH1 mutations were on average 6 years younger than those without these alterations.
  21. pmc PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    Anne Marie Bleau
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 4:226-35. 2009
    ..We investigated the SP phenotype of mouse and human gliomas. In glioma endothelial cells, ABC transporter function is impaired, corresponding to disruption of the BBB in these tumors...
  22. ncbi Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
    Hayato Takeuchi
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3336-46. 2005
    ..However, the mechanisms underlying the cytotoxic effects of a selective mTOR inhibitor, rapamycin, on malignant glioma cells are poorly understood...
  23. ncbi Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
    Jason T Huse
    Departments of Pathology, 408 East 69th Street Z1304, New York, NY 10065, USA
    Nat Rev Cancer 10:319-31. 2010
    ..The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two ..
  24. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
    ..of a novel vaccination with α-type 1 polarized dendritic cells (αDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized by ..
  25. pmc Prediction of Associations between microRNAs and Gene Expression in Glioma Biology
    Stefan Wuchty
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14681. 2011
    ..miR-128 and the protein kinase WEE1, which we subsequently validated experimentally by showing that the over-expression of the naturally under-expressed miR-128 in glioma cells resulted in the inhibition of WEE1 in glioblastoma cells.
  26. ncbi Epidemiology and etiology of gliomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Acta Neuropathol 109:93-108. 2005
    ..With the exception of pilocytic astrocytomas, the prognosis of glioma patients is still poor...
  27. pmc Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
    J D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Death Dis 2:e200. 2011
    ..gliomas contain a population of self-renewing tumorigenic stem-like cells; however, it remains unclear how these glioma stem cells (GSCs) self-renew or generate cellular diversity at the single-cell level...
  28. pmc Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells
    Hongping Xia
    Brain Tumour Centre and Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    J Biol Chem 287:9962-71. 2012
    ..brain-enriched microRNA that plays a crucial role in neural development and has been shown to be down-regulated in glioma and medulloblastoma, suggesting its possible involvement in brain tumor progression...
  29. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
    ..Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC...
  30. pmc Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group
    Wei Yan
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Neuro Oncol 14:1432-40. 2012
    Defining glioma subtypes based on objective genetic and molecular signatures may allow for a more rational, patient-specific approach to molecularly targeted therapy...
  31. ncbi Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    J Holash
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 284:1994-8. 1999
    ....
  32. pmc MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop
    Lili Jiang
    Department of Microbiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    J Clin Invest 122:33-47. 2012
    ..How transformed cells override this NF-κB/IκB negative feedback loop remains unclear. Here, we report in human glioma cell lines that microRNA-30e* (miR-30e*) directly targets the IκBα 3ι-UTR and suppresses IκBα expression...
  33. ncbi Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    Jakub Godlewski
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, Ohio 43210
    Cancer Res 68:9125-30. 2008
    ..miR-128 expression significantly reduced glioma cell proliferation in vitro and glioma xenograft growth in vivo...
  34. ncbi Analysis of the IDH1 codon 132 mutation in brain tumors
    Jörg Balss
    Clinical Cooperation Unit Neuropathology G380, German Cancer Research Center, 69120, Heidelberg, Germany
    Acta Neuropathol 116:597-602. 2008
    ..The very high frequency of IDH1 mutations in WHO grade II astrocytic and oligodendroglial gliomas suggests a role in early tumor development...
  35. ncbi Cost of migration: invasion of malignant gliomas and implications for treatment
    A Giese
    Department of Neurosurgery, University Hospital Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Clin Oncol 21:1624-36. 2003
    ..This raises the question of whether invasive glioma cells activate cellular programs that render these cells resistant to conventional treatments...
  36. pmc Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    Barbara S Paugh
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 28:3061-8. 2010
    To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG).
  37. pmc Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
    Margaret Wrensch
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 41:905-8. 2009
    The causes of glioblastoma and other gliomas remain obscure. To discover new candidate genes influencing glioma susceptibility, we conducted a principal component-adjusted genome-wide association study (GWAS) of 275,895 autosomal variants ..
  38. ncbi Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology
    Lonneke A M Gravendeel
    Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cancer Res 69:9065-72. 2009
    ..To improve current classification standards, we have performed gene expression profiling on a large cohort of glioma samples of all histologic subtypes and grades...
  39. pmc Correlation of microRNA-372 upregulation with poor prognosis in human glioma
    Gang Li
    Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, No 569, Xinsi Road, Xi an 710038, China
    Diagn Pathol 8:1. 2013
    ..The association of miR-372 expression with clinicopathological factors or prognosis of glioma patients was also statistically analyzed...
  40. pmc RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways
    Jun Muto
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    PLoS ONE 7:e33431. 2012
    ..Here, we examined its role in the progression of glioma. Short hairpin RNA (shRNA)-based MSI1-knock down (KD) in glioblastoma and medulloblastoma cells resulted in a ..
  41. pmc Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion
    Lincoln A Edwards
    Neuro Oncology Branch, National Cancer Institute National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1002, USA
    J Natl Cancer Inst 103:1162-78. 2011
    ..Connective tissue growth factor (CTGF) has been previously implicated in cancer metastasis and invasion in various tumors. We explored the mechanism of CTGF-mediated glioma cell infiltration and examined potential therapeutic targets.
  42. pmc MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    Galina Gabriely
    Center of Neurologic Diseases, Brigham and Women s Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA
    Mol Cell Biol 28:5369-80. 2008
    ..We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of ..
  43. ncbi MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC
    Takashi Sasayama
    Department of Neurosurgery, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, Japan
    Int J Cancer 125:1407-13. 2009
    ..Here, we performed real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays on 43 glioma samples (17 glioblastoma, 6 anaplastic astrocytoma, 10 low-grade astrocytoma, 6 oligodendroglioma and 4 ependymoma)..
  44. ncbi Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery BH 19 110, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    J Clin Oncol 26:4189-99. 2008
    ..methyltransferase (MGMT) remains a significant barrier to the successful treatment of patients with malignant glioma. The relative expression of MGMT in the tumor may determine response to alkylating agents, and epigenetic ..
  45. ncbi hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells
    Lei Shi
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China
    Brain Res 1236:185-93. 2008
    ..Several miRNAs have been recently reported to be involved in modulation of glioma development, especially some up-regulated miRNA, such as hsa-miR-21 and hsa-miR-221...
  46. pmc Upregulation of SATB1 is associated with the development and progression of glioma
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 280 Mo He Road, Bao Shan District, Shanghai 201900, China
    J Transl Med 10:149. 2012
    ..This study was aimed at investigating the expression and potential role of SATB1 in human glioma.
  47. ncbi The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling
    Yi fang Ping
    Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    J Pathol 224:344-54. 2011
    ..Here we report the detection of CD133(+) glioma stem-like cells (GSCs) co-expressing a chemokine receptor CXCR4 in human primary glioma tissues...
  48. pmc An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    Dan Rohle
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 340:626-30. 2013
    ..Blockade of mIDH1 impaired the growth of IDH1-mutant--but not IDH1-wild-type--glioma cells without appreciable changes in genome-wide DNA methylation...
  49. pmc The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma
    Mohammed G Abdelwahab
    Neuro Oncology Research, Barrow Neurological Institute of St Joseph s Hospital and Medical Center, Phoenix, Arizona, United States of America
    PLoS ONE 7:e36197. 2012
    ..Diet-induced ketosis causes changes to brain homeostasis that have potential for the treatment of other neurological diseases such as malignant gliomas...
  50. ncbi Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha
    A Soeda
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Oncogene 28:3949-59. 2009
    ..factor-1alpha (HIF-1alpha) activation in tumor angiogenesis is well known, their role in the regulation of glioma-derived stem cells is unclear...
  51. pmc Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis
    Christina Wanka
    Dr Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany
    J Biol Chem 287:33436-46. 2012
    ..p53 in glioblastoma cells could confer a selective advantage to these cells under the adverse conditions of the glioma microenvironment...
  52. ncbi Pseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma
    L C Hygino da Cruz
    Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    AJNR Am J Neuroradiol 32:1978-85. 2011
    The current standard of care for newly diagnosed cases of high-grade glioma is surgical resection followed by RT with concurrent chemotherapy...
  53. ncbi Identification and functional characterization of microRNAs involved in the malignant progression of gliomas
    Bastian Malzkorn
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    Brain Pathol 20:539-50. 2010
    ..We explored the role of microRNAs (miRNAs) in glioma progression by investigating the expression profiles of 157 miRNAs in four patients with primary WHO grade II ..
  54. pmc Genome-wide association study of glioma and meta-analysis
    Preetha Rajaraman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Genet 131:1877-88. 2012
    ..We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-..
  55. pmc MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis
    Yan Cheng
    Department of Pharmacology and The Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, Hershey 17033, USA
    Mol Cancer Ther 11:154-64. 2012
    ..in phase I trials in patients with solid tumors, could reinforce the cytocidal effect of gefitinib against glioma. We found that cotreatment with gefitinib and MK-2206 increased the cytotoxicity of this growth factor receptor ..
  56. pmc VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling
    Lingchao Chen
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, China
    Neuro Oncol 14:1026-36. 2012
    ..Here, we investigated the oncogenic significance and function of miR-23b in glioma. We identified that the expression of miR-23b was elevated in both glioma samples and glioma cells, indicated by ..
  57. ncbi Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells
    F Orzan
    Fondazione I R C C S Istituto Neurologico C Besta, Milan, Italy
    Neuropathol Appl Neurobiol 37:381-94. 2011
    ..The histone methyltransferase Enhancer of Zeste 2 (EZH2) is a key member of PRC2 function: we have investigated its expression and function in gliomas...
  58. pmc p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    Hongwu Zheng
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:1129-33. 2008
    ..CNS)-specific deletion of p53 and Pten in the mouse CNS generates a penetrant acute-onset high-grade malignant glioma phenotype with notable clinical, pathological and molecular resemblance to primary GBM in humans...
  59. pmc FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
    Nu Zhang
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 20:427-42. 2011
    ..FoxM1-β-catenin interaction controls Wnt target gene expression, is required for glioma formation, and represents a mechanism for canonical Wnt signaling during tumorigenesis.
  60. ncbi Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial
    Walter Stummer
    Neurochirurgische Klinik, Heinrich Heine University, Dusseldorf, Germany
    Lancet Oncol 7:392-401. 2006
    ..We aimed to assess the effect of fluorescence-guided resection with 5-aminolevulinic acid on surgical radicality, progression-free survival, overall survival, and morbidity...
  61. ncbi MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
    Michael Weller
    Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland
    Nat Rev Neurol 6:39-51. 2010
    ..In other subtypes of glioma, such as anaplastic gliomas, the relevance of MGMT promoter methylation might extend beyond the prediction of ..
  62. ncbi microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    Yun Wu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 46:1707-18. 2005
    ..Radiolabeled RGD peptides that are integrin specific can be used for noninvasive imaging of integrin expression level as well as for integrin-targeted radionuclide therapy...
  63. pmc Mosaic analysis with double markers reveals tumor cell of origin in glioma
    Chong Liu
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Cell 146:209-21. 2011
    ..Our findings suggest OPCs as the cell of origin in this model, even when initial mutations occur in NSCs, and highlight the importance of analyzing premalignant stages to identify the cancer cell of origin...
  64. ncbi Differentiation therapy exerts antitumor effects on stem-like glioma cells
    Benito Campos
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 16:2715-28. 2010
    ..tumor subpopulation, which is believed to substantially influence tumor initiation and therapy resistance in glioma. Currently, therapeutic, drug-induced differentiation is considered as a promising approach to eradicate this ..
  65. ncbi Genetic alterations and signaling pathways in the evolution of gliomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Cancer Sci 100:2235-41. 2009
    ..In this review, we summarize the current status of genetic alterations and signaling pathways operative in the evolution of astrocytic and oligodendroglial tumors...
  66. ncbi Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    Tatyana N Ignatova
    Departments of Neuroscience and Neurosurgery, McKnight Brain Institute and Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    Glia 39:193-206. 2002
    ..Moreover, the individual glioma-derived clones contain cells immunopositive separately for GFAP or neuronal beta-III tubulin, as well as single ..
  67. pmc Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    Shimin Zhao
    Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, 130 Dong an Road, Shanghai 200032, China
    Science 324:261-5. 2009
    ..Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway...
  68. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
    ..we demonstrate that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy...
  69. ncbi Apparent diffusion coefficient histograms may predict low-grade glioma subtype
    Daniel J Tozer
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    NMR Biomed 20:49-57. 2007
    The subtypes of glioma are known to have different prognosis and response to treatment...
  70. pmc Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
    Meghan J Seltzer
    Department of Neurosurgery, and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 70:8981-7. 2010
    ..The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy...
  71. ncbi Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
    Tatsuya Takezaki
    Laboratory for Cell Lineage Modulation, RIKEN Center for Developmental Biology, Kobe, Japan
    Cancer Sci 102:1306-12. 2011
    ..In this study, we established two primary human glioma cell lines from anaplastic oligodendroglioma and glioblastoma multiforme...
  72. ncbi miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1
    Weiyi Xu
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, P R China
    Int J Oncol 42:757-66. 2013
    ..The two miRNAs promote glioma cell proliferation via targeting MXI1 and the experiment was confirmed by the rescue experiments...
  73. pmc Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes
    Aiguo Li
    Neuro Oncology Branch and Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 69:2091-9. 2009
    ..Defining glioma subtypes based on objective genetic and molecular signatures may allow for a more rational, patient-specific ..
  74. pmc TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets
    Libing Song
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Zhongshan School of Medicine, Ministry of Education, Sun Yat Sen University, Guangzhou, China
    J Clin Invest 122:3563-78. 2012
    ..promoted ubiquitin conjugation of NF-κB signaling pathway components and induction of an aggressive phenotype of glioma cells both in vitro and in vivo...
  75. pmc Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    Adam Wu
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 12:1113-25. 2010
    ..b>Glioma cancer stem cells (gCSCs) have been shown to suppress adaptive immunity, but their role in innate immunity with ..
  76. ncbi Molecular subclassification of diffuse gliomas: seeing order in the chaos
    Jason T Huse
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
    Glia 59:1190-9. 2011
    ..constellation of positive prognostic molecular features is enriched in the transcriptionally defined Proneural glioma subclass and appears to reflect a route of pathogenesis distinct from that taken by other high-grade diffuse ..
  77. pmc Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    Albert Lai
    David Geffen School of Medicine at theUniversity of California at Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 29:4482-90. 2011
    ..To determine how GBMs arising with IDH1(R132MUT) differ from other GBMs, we undertook a comprehensive comparison of patients presenting clinically with primary GBM as a function of IDH1(R132) mutation status...
  78. pmc The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors
    Nhan L Tran
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
    Am J Pathol 162:1313-21. 2003
    ..To assess possible mechanisms and to potentially target invasive glioma cells, we previously measured the gene expression profiles of glioma cells under migration-activated or passive ..
  79. ncbi Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
    T Kanzawa
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Death Differ 11:448-57. 2004
    ..In this study, we present that temozolomide (TMZ), a new alkylating agent, inhibited the viability of malignant glioma cells in a dose-dependent manner and induced G2/M arrest...
  80. pmc Epidemiology of primary brain tumors: current concepts and review of the literature
    Margaret Wrensch
    Department of Epidemiology and Biostatistics University of California at San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 4:278-99. 2002
    ..Inverse associations of the history of allergies with glioma risk observed in 3 large studies and reports of inverse associations of glioma with common infections suggest a ..
  81. ncbi The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects
    Kirsten Hattermann
    Department of Anatomy, University of Kiel, Center, Kiel, Germany
    Cancer Res 70:3299-308. 2010
    ..In situ, CXCR7 is highly expressed on tumor endothelial, microglial, and glioma cells whereas CXCR4 has a much more restricted localization; CXCL12 is often colocalized with CXCR7...
  82. pmc Human glioma growth is controlled by microRNA-10b
    Galina Gabriely
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 71:3563-72. 2011
    ..a miRNA not expressed in human brain and strongly upregulated in both low-grade and high-grade gliomas, reduces glioma cell growth by cell-cycle arrest and apoptosis...
  83. pmc DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    J Natl Cancer Inst 103:143-53. 2011
    Although much is known about molecular and chromosomal characteristics that distinguish glioma histological subtypes, DNA methylation patterns of gliomas and their association with other tumor features such as mutation of isocitrate ..
  84. pmc Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers
    Michael Jansen
    Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet Neurol 9:717-26. 2010
    ..Given these developments, the pace of discovery of new molecular assays will quicken to facilitate personalised medicine in the setting of malignant glioma.
  85. pmc Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases
    T Papagiannakopoulos
    Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA
    Oncogene 31:1884-95. 2012
    ..Gliomas are aggressive brain tumors that are thought to arise from transformed glioma-initiating neural stem cells (giNSCs)...
  86. ncbi Glioma extent of resection and its impact on patient outcome
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Neurosurgery 62:753-64; discussion 264-6. 2008
    There is still no general consensus in the literature regarding the role of extent of glioma resection in improving patient outcome...
  87. ncbi Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    Marc Sanson
    L Institut National de la Santé et de la Recherche Médicale U711, Fédération de Neurologie Mazarin, Groupe Hospitalier Pitie Salpetriere, 75651, Paris Cedex 13, France
    J Clin Oncol 27:4150-4. 2009
    ..Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas...
  88. ncbi PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
    Erica L Jackson
    Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:187-99. 2006
    ..Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation...
  89. ncbi Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance
    Elizabeth B Claus
    Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer 103:1227-33. 2005
    ..assessments of the association between extent of resection and risk of either recurrence or death exist for neurosurgical patients who undergo resection of low-grade glioma using intraoperative magnetic resonance image (MRI) guidance.
  90. ncbi Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    Dominique B Hoelzinger
    Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    J Natl Cancer Inst 99:1583-93. 2007
    ..Drivers of glioma invasion include autocrine signals propagated by secreted factors that signal through receptors on the tumor...
  91. pmc Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    Nikki Charles
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 6:141-52. 2010
    ..eNOS expression is highly elevated in tumor vascular endothelium adjacent to perivascular glioma cells expressing Nestin, Notch, and the NO receptor, sGC...
  92. ncbi Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin
    Vanesa Martin
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina de la Universidad de Oviedo, Calle Julian Claveria, 33006 Oviedo, Spain
    Cancer Res 66:1081-8. 2006
    ..In the present work, we found that millimolar concentrations of this indolamine reduced cell growth of C6 glioma cells by 70% after 72 hours of treatment, inhibiting cell progression from G(1) to S phase of the cell cycle...
  93. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
    ..the combination of basic fibroblast growth factor and platelet-derived growth factor maintains SP cells in the C6 glioma cell line...
  94. ncbi Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma
    Lindy E Barrett
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 21:11-24. 2012
    ....
  95. pmc The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells
    Theresa A Ulrich
    Department of Bioengineering, University of California Berkeley and University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, Berkeley, CA 94720 1762, USA
    Cancer Res 69:4167-74. 2009
    ..We cultured a series of glioma cell lines (U373-MG, U87-MG, U251-MG, SNB19, C6) on fibronectin-coated polymeric ECM substrates of defined ..
  96. ncbi The prostate stem cell antigen represents a novel glioma-associated antigen
    K D Geiger
    Department of Neuropathology, Institute for Pathology, Medical Faculty Carl Gustav Carus, D 01307 Dresden, Germany
    Oncol Rep 26:13-21. 2011
    ..001). Our results suggest that increased PSCA expression levels are linked to gliomas of WHO grades III and IV, and may represent a suitable additional target for immunotherapy of gliomas...
  97. ncbi Temozolomide in malignant gliomas: current use and future targets
    J Lee Villano
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Chemother Pharmacol 64:647-55. 2009
    ..We summarize developing concerns regarding the use of TMZ, imaging of malignant gliomas, and the pharmacology of TMZ-mechanism of action, scheduling and strategies for overcoming resistance...
  98. ncbi Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery
    Jianwei Guo
    Department of Pharmaceutics, Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, PR China
    Biomaterials 32:8010-20. 2011
    ..of both cancer cells and endothelial cells in angiogenic blood vessels, as the targeting ligand to facilitate anti-glioma delivery of paclitaxel (PTX)...
  99. ncbi MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf
    Hong Fei Xia
    Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, China
    Cell Physiol Biochem 23:347-58. 2009
    ..In the present study, the possible mechanisms by which one neuronal miRNAs, miR-125b, affected the growth of nervous cells were investigated using in vitro cell line model...
  100. pmc Development of a novel mouse glioma model using lentiviral vectors
    Tomotoshi Marumoto
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Med 15:110-6. 2009
    ..We suggest that the use of Cre-loxP-controlled lentiviral vectors is a novel way to generate a mouse glioblastoma multiforme model in a region- and cell type-specific manner in adult mice...
  101. ncbi Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...

Research Grants74

  1. EGFR activity in T cell-influenced glioma invasiveness & chemosensitivity
    Christopher Wheeler; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is a uniformly fatal primary brain tumor (glioma) for which there is no effective treatment...
  2. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..cell proliferation, invasion, and metastasis in human cancers, including breast, prostate, pancreatic cancers and glioma. Moreover, others also showed that miR-146a/b negatively regulate NF-κB activity by inhibiting expression ..
  3. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..In Aim 2 we will determine whether loss of the known glioma tumor suppressors (INK4a, Arf, PTEN) will promote the incorporation and contribution of recruited cells to the ..
  4. CPG METHYLATION AND MUTATION
    Gerd P Pfeifer; Fiscal Year: 2013
    ..this hypothesis using a neural stem cell and brain tumor model, which includes neural stem cells, stem cell-like glioma cells, and DNA samples from glioma tumors...
  5. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..In vivo studies with orthotopic GBM mouse models will assess the combination treatment of MGMTi-SNAs and TMZ;we intend to (1) enhance intratumoral apoptosis, (2) reduce glioma formation, and (3) increase survival time.
  6. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..Our laboratory has produced a large amount of preliminary data indicating that glioma cells are sensible to cell death induced by triggering endoplasmic reticulum stress response (ERSR)...
  7. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..4) To determine how RSK2 regulation of integrin activation affects glioma invasion. We previously reported that PEA-15 expression blocks glioma invasion...
  8. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..gold nanoparticle (Au NP-Pc 4) conjugates with a thiolated PEG coating for targeted imaging-guided therapy of glioma brain cancers...
  9. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..and tumor tissue to address hypotheses regarding cancers of the prostate, colon and rectum, breast, and brain (glioma)...
  10. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..may also prevent clinical progression of the tumor by thwarting the invasive infiltration that characterizes glioma growth...
  11. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..Engineering the Brain Immune System for Tumor Therapy Abstract Brain glioblastoma multiforme (GBM) kills through glioma cells that infiltrate normal surrounding brain, with consequent displacement and destruction of healthy brain ..
  12. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..implicated in human neurological diseases such as amyotrophic lateral sclerosis, epilepsy, depression, suicide, glioma, and cancers, and may have contributed to the evolutionary development of human neurobiology and cognition...
  13. PET TUMOR AND PROLIFERATION IMAGING VIA CATIONIC AMINO ACID TRANSPORT
    JONATHAN EDWARD MCCONATHY; Fiscal Year: 2013
    ..be synthesized, and their mechanisms of transport will be determined in vitro using rat 9L gliosarcoma, mouse DBT glioma and mouse mammary adenocarcinoma 66 cell lines...
  14. Glutamate-Glutamine Metabolism in Primary Human Brain Tumors
    Anne Williamson; Fiscal Year: 2010
    ..The death of surrounding normal neurons and glia allows the glioma to invade into the surrounding neuropil...
  15. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..GBM is characterized by survival of glioma cells following initial treatment, invasion through the brain parenchyma and destruction of normal brain tissues, ..
  16. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ..among others the GluR1/2 subunits of the AMPA receptor (AMPAR), the GABA(B1) receptor (GABA(B1)R), Leucine rich glioma inactivated 1 (LGI1) and Contactin associated protein 2 (Caspr2)...
  17. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Systemic immunization against glioma has not yielded beneficial effects, since it is limited by progressive tumor mutation, and a brain micro-..
  18. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..Grade IV glioblastoma multiforme (GBM), the most malignant and common glioma, with a mean survival time of less than 1 year despite aggressive therapy that combines state-of- the-art imaging ..
  19. The effects of dexamethasone on tumor and microglial cells in glioma
    TERREIA SUTTON JONES; Fiscal Year: 2013
    ..the mechanism of how Dex works and potentially lead to a paradigm shift in how neurologic symptoms are managed in glioma. We will address the hypothesis that Dex inhibits tumor cell proliferation either in a direct cell autonomous ..
  20. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..integrin is expressed in neural stem cells and astroglia, which are presumptive cells of origin for glioma;(ii) genetic ablation of the murine av or [unreadable]8 integrin genes in mouse neural stem cells and astroglia ..
  21. Glypican-1 in gliomagenesis
    Andreas Friedl; Fiscal Year: 2013
    ..Despite advances in therapy, this dismal prognosis has not changed significantly. One of the hallmarks of glioma cells is their genetic instability, which contributes to progression and therapy resistance...
  22. Methylmercury exposure, mercury metabolism genotypes, and risk of adult glioma
    Kathleen M Egan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Glioma is a highly lethal malignancy with unknown etiology that accounts for nearly 80% of adult malignant brain tumors...
  23. Oncogene cooperation in glioma genesis
    Wei Zhang; Fiscal Year: 2013
    ..Gliomas represent the single most frequent type of primary brain malignancy. The most advanced form of glioma, and also the most invasive and refractory to therapy, is glioblastoma (GBM), which comprises 50-60% of all ..
  24. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012
    ..of a9[unreadable]1 with TSP-1 is an important element of pathological angiogenesis occurring during diffusive glioma development...
  25. Allergic Condition Susceptibility Polymorphisms and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2012
    The most common type of adult glioma (a primary malignant brain tumor), glioblastoma, has a five-year survival probability of only 3%...
  26. Developing diagnostic and therapeutic stem cells for cancer therapy
    Khalid A Shah; Fiscal Year: 2013
    ..deposits in the brain and have apoptotic and antiangiogenic effects when transplanted into mouse models of glioma;and b) the dynamics of receptor targeted anti-tumor therapies and fate of stem cells can be visualized in real ..
  27. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    ..Further, the glioma initiating cells are resistant to radiotherapy...
  28. Modulation of Glioma Growth and Invasion by HCMV Glycoprotein B
    Liliana Soroceanu; Fiscal Year: 2010
    ..correlate with patient survival, suggesting that HCMV may induce a shift towards a more aggressive and invasive glioma phenotype...
  29. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Malignant glioma is characterized by early local invasion, microsatellite infiltration of healthy CNS tissue and dispersion of tumor cells in distant parenchyma...
  30. Measles Virotherapy and radiovirotherapy in the Treatment of recurrent gliomas
    Evanthia Galanis; Fiscal Year: 2013
    ..Their tumor specificity is due to abundant expression of the MV receptor CD46 in glioma cells...
  31. Glioma immunotherapy with strategies based on autonomous parvovirus MVMp
    JUSTIN COBB PAGLINO; Fiscal Year: 2013
    ..The research strategy describes our approach to attempting to cure syngeneic orthotopic malignant glioma using an oncolytic parovirus combined with therapies that we hypothesize will synergize with parvovirus therapy ..
  32. Identification of novel system xc- inhibitors
    BARBARA STAUCH SLUSHER; Fiscal Year: 2012
    ..As a future goal, lead compounds arising from these studies will be tested in animal models of glioma and multiple sclerosis and the validated 96-well assay will be further miniaturized to a 384-well format for high ..
  33. Polyvalent siRNA-Gold Nanoparticle Constructs to Eradicate Glioma
    Emily S Day; Fiscal Year: 2012
    ..This research will develop a new therapy to meet this need that may be extended to other cancers and diseases in the future as well, substantially impacting public health. ..
  34. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2013
    ..emergence of the epidermal growth factor receptor variant III (EGFRvIII) as a tumor-specific molecular target on glioma and other tumors, research during the previous grant period was focused on the development of strategies for ..
  35. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..Similarly, high PKC activity is frequently observed in malignant gliomas and has been associated with glioma drug resistance...
  36. Immune effector-mediated killing of CNS tumors in the GL261 model of glioblastoma
    DANIELLE RENNER; Fiscal Year: 2013
    ..experimental model systems and develop immunotherapeutic strategies that enhance anti-tumor immunity to remove glioma cells left behind following surgery...
  37. Genotype and Metabolic Phenotype in Glioblastoma
    Elizabeth A Maher; Fiscal Year: 2010
    ..will define the metabolic phenotype in glioblastoma patients undergoing surgical resection for presumed high grade glioma. In each patient, 13C NMR spectral analysis of tumor extracts will be obtained after intra-operative infusion of [..
  38. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..Together, these features commensurably complement the retrospective studies brought forward by The Cancer Genome Atlas by providing a much-needed animal system capable of efficient analysis of gene function. ..
  39. Defining the role of mutant IDH in glioma initiation and maintenance
    Sheri L Holmen; Fiscal Year: 2013
    ..The objective of this study is to define the role of IDH mutations in glioma formation, maintenance, and response to therapy...
  40. Role of Olig Genes in Human Gliomagenesis
    Santosh Kesari; Fiscal Year: 2011
    ..preliminary studies, we have shown 1) that 100% of CD133-positive stem cells in fresh surgical isolates of human glioma express the gliogenic transcription factor OLIG2, 2) that OLIG2 is essential for tumor formation in a mouse model ..
  41. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..or VEGF-R2 (vascular endothelial growth factor receptor), can be used therapeutically to inhibit or diminish glioma tumor growth in experimental rodent models...
  42. A Novel Brachytherapy Agent for GBM
    FRANK CALZONE; Fiscal Year: 2013
    ..malignant gliomas has been traditionally performed via invasive radioactive probes placed intracranially into the glioma. The use of 131I-VCN to selectively target integrins overexpressed on the angiogenic tumor endothelial cells and ..
  43. Glioma Associated Macrophages Facilitate Local Immunosuppression
    Orin Bloch; Fiscal Year: 2010
    ..Malignant glioma is a deadly form of brain tumor that is notoriously immunosuppressive...
  44. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    Sean J Morrison; Fiscal Year: 2013
    ..We discovered that Leucine-rich glioma inactivated gene-4 (Lgi4), which encodes a secreted protein, was much more highly expressed in NCSCs...
  45. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..Aim II will establish the distribution of the drug-conjugate and the drug in glioma xenografts, their associated vasculature and the adjacent normal brain...
  46. A Bi-Institutional Pilot Study of Vaccinations for Patients with Low Grade Glioma
    Edward G Shaw; Fiscal Year: 2010
    ..and the Comprehensive Cancer Center of Wake Forest University of a vaccination regime (subcutaneous injections of glioma-associated antigen [GAA]-derived cytotoxic T-lymphocyte [CTL] epitope-peptides with simultaneous intramuscular [i...
  47. Lentiviral-MGMT gene transfer into hematopoietic stem cells
    Stanton L Gerson; Fiscal Year: 2011
    ..to demonstrate safe use of lentiviral vector with the potential to improve outcomes for patients with advanced glioma, will be initiated...
  48. Oxygen as a master immunologic switch
    Christopher A Pennell; Fiscal Year: 2013
    ..in the form of personalized vaccines has demonstrated immunologic activity and clinical responses in select glioma patients with minimal toxicity...
  49. Interplay between intrinsic and extrinsic force and glioma aggression
    Matt Barnes; Fiscal Year: 2013
    ..Glioblastoma multiforme (GBM), the most common form of glioma, is associated with dismal clinical prognosis...
  50. Discovery Tools for Chemotherapy Resistance to Cell Death.
    Robert W Sobol; Fiscal Year: 2012
    ..These lentiviruses will be used for the development of stable cell lines with specific gene knockdown in both the glioma cell line LN428 and the colon cancer cell line HCT-116, followed by mRNA expression (qRT-PCR) characterization of ..
  51. Molecular Mechanisms of IDH1-mediated Gliomagenesis
    Ingo K Mellinghoff; Fiscal Year: 2013
    ..While these observations point toward a unique molecular pathogenesis of IDH1-mutant glioma, no experimental evidence thus far has incriminated mutant IDH1 as the cause of CIMP or documented its role in ..
  52. In vivo detection of involvement of endogenous BM progenitor cells in glioma
    Ali Syed Arbab; Fiscal Year: 2013
    ..The goal of this study is to elucidate neovascularization mechanisms in refractory glioma by making chimeric mouse model and applying novel non-invasive, state of the art MRI and optical imaging approach ..
  53. Novel approaches to enhance tumor cell cytotoxicity of alkylating agents
    Robert W Sobol; Fiscal Year: 2013
    ..control cellular responses to alkylating agents with the goal of increasing TMZ-induced cytotoxicity in cells from glioma tumors...
  54. IGF1R: A candidate oncogene in pediatric high grade gliomas
    Claudia P Miller; Fiscal Year: 2012
    ..by which IGF1R drives astrocytic tumorigenesis;and ii) evaluate the effects of targeting IGF1R signaling in this glioma mouse model...
  55. Paraptosis induction by BK channel activation to improve glioma cancer therapy
    Martin R Jadus; Fiscal Year: 2013
    ..provided by applicant): Our goal is to further understand the mechanism by which brain cancer cells, known as glioma cells, killed by prolonged BK ion channel activation can stimulate immune responses to improve immune therapy ..
  56. Regulation of ClC-3 in Human Malignant Glioma
    Vishnu Anand Cuddapah; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Malignant glioma, the most common and lethal type of primary brain cancer, affects about 5 in 100,000 people...
  57. Application of Carbon Nanotubes for Macrophage Activation in Brain Tumor Models
    Behnam Badie; Fiscal Year: 2010
    ..immunotherapy based on MG/MP activation, we propose to study the efficacy of CNTs for siRNA delivery into MG/MP in glioma models. In the first Aim of the project, we will optimize the efficacy of CNTs for siRNA delivery into MG in vitro...
  58. Inhibition of Autophagy Enhances Anti-Angiogenic Efficacy in Intracranial Glioma
    Martin M Pike; Fiscal Year: 2013
    ..Specific Aim 1 will characterize the dose-dependent in vitro responses of mouse (4C8) and human (U87) glioma cells to Cediranib and quinacrine, singly and in combination, under normal and oxygen glucose deprived conditions...
  59. The Significance of Isocitrate Dehydrogenase Mutations in Gliomas
    CRAIG MICHAEL HORBINSKI; Fiscal Year: 2013
    ..The most common type of brain tumor is the diffusely infiltrative glioma;these tumors cannot be completely excised surgically, and are difficult to treat with radiation and chemotherapy...
  60. Na-K-Cl cotransporter in Glioblastoma Multiforme
    Dandan Sun; Fiscal Year: 2013
    ..led us to hypothesize that NKCC1 activity is stimulated in the TMZ-treated cells and its inhibition can sensitize glioma to TMZ-mediated apoptosis...
  61. Imaging Cytolytic T Cells in Cancer Patients Using PET Reporter Genes/Reporter Pr
    Sanjiv S Gambhir; Fiscal Year: 2012
    ..Aim 1. Optimization of [18F]FHBG PET-CT imaging in glioma patients to characterize background [18F]FHBG signal in areas of tumor with a compromised blood-brain-barrier as ..
  62. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..we have identified the genetic defect underlying the claw paw mutation as an insertion in the Lgi4 (Leucine-rich glioma inactivated-4) gene. This gene is expressed by Schwann cells, and encodes a secreted protein of unknown function...
  63. Tailoring AAV Vectors for Glioma Immunotherapy
    Ou Cao; Fiscal Year: 2011
    ..AAV gene transfer in glioma (GL) models has revealed that transduction efficiencies are highly variable between serotypes, and despite reports ..
  64. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..of a bieistronic construct (Ad-uPAR-pl6), with the antisense uPAR gene and the sense tumor suppressor gone p16, on glioma cell growth, attachment, migration, and invasion in vitro, la) Determine the effect of the bicistronic Ad-uPAR-pl ..
  65. Stem Cells as Delivery Vehicles and Imaging Probes for Glioma Gene Therapy
    Syed Ali; Fiscal Year: 2009
    ..cells (EPCs), a class of hematopoietic stem cells, to migrate and incorporate into the angiogenesis of implanted glioma. EPCs have migrated actively at the periphery of the tumors when administered intravenously or locally and ..
  66. AGT DEPLETION FOR THERAPY OF CNS TUMORS
    Jennifer Quinn; Fiscal Year: 2004
    The prognosis of patients with malignant glioma remains dismal, with conventional treatment with surgery, radiotherapy and alkylnitrosourea-based chemotherapy failing to cure all patients with glioblastoma multiforme and the majority of ..
  67. COMBATING ALKYLATING AGENT RESISTANCE IN HUMAN GLIOMAS
    JOHN SILBER; Fiscal Year: 2002
    ..The broad, long-term objective is to define the contribution of DNA repair mechanisms to glioma resistance to chemotherapeutic agents (methylating and chloroethylating agents), and to identify strategies to ..
  68. Allergic Condition Biomarkers and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2004
    An inverse association between self-reported allergic conditions (ACs) and glioma has been previously observed in seven case-control and two cohort studies...
  69. ANNEXIN II & PLASMIN MEDIATED HIGH GRADE GLIOMA INVASION
    Suchitra Acharya; Fiscal Year: 2002
    ..We have employed C6 rat glioma cells, a well-defined in vitro model of human high grade glioma to study the potential role of Ann II in plasmin - ..
  70. Conditional Replicating Adenovirus for Glioma Treatment
    Juan Fueyo; Fiscal Year: 2006
    ..Promising therapies can be designed by targeting fundamental molecular defects of the glioma cells...
  71. TOWARDS A REFINED MOLECULAR RECURSIVE PARTITIONING ANALYSIS MODEL FOR GLIOBLASTOM
    WALTER JOHN contact CURRAN; Fiscal Year: 2010
    ..cooperative groups in oncology, has developed a recursive partitioning analysis (RPA) model for malignant glioma patients, using primarily clinical and demographic variables to stratify malignant glioma patients into one of six ..
  72. Chemoprevention of Gliomas using Nitrones with Anti-c-Met Activity
    Rheal Towner; Fiscal Year: 2009
    ..is focused on establishing the mechanism of alpha-phenyl-tert-butyl nitrone (PBN), in its ability to inhibit glioma formation in experimental rodent models that vary in tumor grade...
  73. Gutless Adenovirus Mediated Targeted Therapeutics for Glioma
    Marianela Candolfi; Fiscal Year: 2009
    ..Thus, its fusion to IL-13 retargets the cytotoxic molecule to IL13a2R-expressing glioma cells. Mutants of IL-13, such as IL13...
  74. Bone Marrow Stem Cells: Novel Treatment of Human Glioma
    Frederick F Lang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Successful treatment of human glioma, the most deadly brain tumor, has not been achieved in large part because of deficiencies in current delivery strategies...