squamous cell carcinoma

Summary

Summary: A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Top Publications

  1. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
  2. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  3. doi Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
  4. ncbi Esophageal cancer
    Peter C Enzinger
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 349:2241-52. 2003
  5. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
  6. pmc Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase
    Matthew R Clay
    Department of Molecular and Cell Biology, University of Wisconsin, Madison, Wisconsin, USA
    Head Neck 32:1195-201. 2010
  7. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
  8. pmc Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
  9. doi Platinum-based chemotherapy plus cetuximab in head and neck cancer
    Jan B Vermorken
    Antwerp University Hospital, Department of Medical Oncology, Edegem, Belgium
    N Engl J Med 359:1116-27. 2008
  10. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000

Research Grants

  1. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
  2. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
  3. Tatiana Efimova; Fiscal Year: 2014
  4. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
  5. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
  6. Vernon K Sondak; Fiscal Year: 2016
  7. Cong Yan; Fiscal Year: 2014
  8. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
  9. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
  10. Edward A Neuwelt; Fiscal Year: 2015

Detail Information

Publications421 found, 100 shown here

  1. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  2. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  3. doi Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
    Thian Sze Wong
    Department of Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR China
    Clin Cancer Res 14:2588-92. 2008
    The aim of this study was to evaluate the microRNA expression patterns in squamous cell carcinoma (SCC) of the tongue.
  4. ncbi Esophageal cancer
    Peter C Enzinger
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 349:2241-52. 2003
  5. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
    ..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
  6. pmc Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase
    Matthew R Clay
    Department of Molecular and Cell Biology, University of Wisconsin, Madison, Wisconsin, USA
    Head Neck 32:1195-201. 2010
    ..We previously reported that CD44 isolates tumorigenic cells from head and neck squamous cell cancer (HNSCC). Recent studies indicate that aldehyde dehydrogenase (ALDH) activity may represent a more specific marker of CSCs...
  7. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  8. pmc Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN).
  9. doi Platinum-based chemotherapy plus cetuximab in head and neck cancer
    Jan B Vermorken
    Antwerp University Hospital, Department of Medical Oncology, Edegem, Belgium
    N Engl J Med 359:1116-27. 2008
    ..We investigated the efficacy of cetuximab plus platinum-based chemotherapy as first-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck...
  10. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  11. pmc MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival
    Ewy A Mathe
    Laboratory of Human Carcinogenesis, National Cancer Institute NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 15:6192-200. 2009
    ..established the role of miRNAs in esophageal carcinoma, a comprehensive multicenter study investigating different histologic types, including squamous cell carcinoma (SCC) and adenocarcinoma with or without Barrett's, is still lacking.
  12. ncbi A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, Section Tumor Biology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Cancer Res 63:1727-30. 2003
    ..6: 963-968, 1953] in 1953 when studying the presence of histologically abnormal tissue surrounding oral squamous cell carcinoma. It was proposed to explain the development of multiple primary tumors and locally recurrent cancer...
  13. pmc Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    M E Prince
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 104:973-8. 2007
    Like many epithelial tumors, head and neck squamous cell carcinoma (HNSCC) contains a heterogeneous population of cancer cells...
  14. doi Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial
    Carole Fakhry
    Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Natl Cancer Inst 100:261-9. 2008
    The improved prognosis for patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) relative to HPV-negative HNSCC observed in retrospective analyses remains to be confirmed in a prospective ..
  15. ncbi Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy
    S Choi
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, corrected Houston, TX 77030 4009, USA
    J Dent Res 87:14-32. 2008
    The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient's genetic predisposition as well as by environmental influences, including ..
  16. doi Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers
    Maura L Gillison
    Division of Viral Oncology, The Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 100:407-20. 2008
    ..We examined whether the risk factors for HPV-16-positive HNSCCs are similar to those for HPV-16-negative HNSCCs in a hospital-based case-control study...
  17. ncbi 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:988-94. 2007
    ..We hypothesized that RAD51 and P53 SNPs may interact and alter risk of squamous cell carcinoma of the head and neck (SCCHN) and we genotyped for RAD51 135G>C and 172G>T and P53 Arg72Pro SNPs in ..
  18. doi Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
    Anil K Chaturvedi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 26:612-9. 2008
    ....
  19. doi Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma
    Shih Hwa Chiou
    Institutes of Oral Biology, Traditional Medicine, and Anatomy and Cell Biology, National Yang Ming University, Taiwan, People s Republic of China
    Clin Cancer Res 14:4085-95. 2008
    Oral squamous cell carcinoma (OSCC), like many solid tumors, contains a heterogeneous population of cancer cells...
  20. ncbi Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck
    Jay S Cooper
    New York University Medical Center, New York, USA
    N Engl J Med 350:1937-44. 2004
    ..We tested the hypothesis that concurrent postoperative administration of cisplatin and radiotherapy would improve the rate of local and regional control...
  21. pmc MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma
    Michele Avissar
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 15:2850-5. 2009
    ..We sought to identify microRNAs altered in head and neck squamous cell carcinoma (HNSCC) and to determine whether microRNA expression is predictive of disease.
  22. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
    ..We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer...
  23. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs...
  24. ncbi p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    James W Rocco
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Cell 9:45-56. 2006
    We demonstrate that deltaNp63alpha is an essential survival factor in head and neck squamous cell carcinoma (HNSCC) through its ability to suppress p73-dependent apoptosis...
  25. pmc Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial
    Manabu Muto
    Department of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan
    J Clin Oncol 28:1566-72. 2010
    ..We compared the real-time diagnostic yield of superficial cancer in these regions between conventional white light imaging (WLI) and narrow band imaging (NBI) in high-risk patients...
  26. ncbi Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    James A Bonner
    Department of Medicine, University of Alabama, Birmingham, USA
    N Engl J Med 354:567-78. 2006
    ....
  27. doi Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
    Li Dong Wang
    Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China
    Nat Genet 42:759-63. 2010
    We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent...
  28. ncbi Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    J Clin Oncol 22:900-8. 2004
    ..the time course of therapy-induced changes in tumor glucose use during chemoradiotherapy of esophageal squamous cell carcinoma (ESCC) and to correlate the reduction of metabolic activity with histopathologic tumor response and ..
  29. doi Recent advances in head and neck cancer
    Robert I Haddad
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 359:1143-54. 2008
  30. pmc Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines
    J Chad Brenner
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 32:417-26. 2010
    We established multiple University of Michigan Squamous Cell Carcinoma (UM-SCC) cell lines. With time, these have been distributed to other labs all over the world...
  31. ncbi Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma
    Makoto Tsuneoka
    Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume, Japan
    Clin Cancer Res 10:7347-56. 2004
    We previously identified mina53, a novel Myc target gene. Here we investigated whether mina53 is related to esophageal squamous cell carcinoma (ESCC), a disease with poor prognosis.
  32. ncbi Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis
    Camille C R Ragin
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Int J Cancer 121:1813-20. 2007
    ..The observed improved OS and DFS for HPV-positive HNSCC patients is specific to the oropharynx; these tumours may have a distinct etiology from those tumours in non-oropharyngeal sites...
  33. pmc Identification of proteomic differences between squamous cell carcinoma of the lung and bronchial epithelium
    Gereon Poschmann
    Medizinisches Proteom Center, Ruhr Universitat Bochum, 44801 Bochum, Germany
    Mol Cell Proteomics 8:1105-16. 2009
    ..approach and compared the proteome of microdissected cells from normal human bronchial epithelium and squamous cell carcinoma tumors of histopathological grades G2 and G3...
  34. doi Overexpression of SATB1 in laryngeal squamous cell carcinoma
    Xu Dong Zhao
    Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang, PR China
    ORL J Otorhinolaryngol Relat Spec 72:1-5. 2010
    To investigate the expression of special AT-rich sequence-binding protein 1 (SATB1), and the relationship between SATB1 and clinicopathological factors of laryngeal squamous cell carcinoma (LSCC).
  35. doi Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma
    Shigeo Haruki
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Carcinogenesis 31:1027-36. 2010
    ..a homozygous loss of protocadherin (PCDH) 17 in the course of a program to screen a panel of esophageal squamous cell carcinoma (ESCC) cell lines for genomic copy number aberrations...
  36. ncbi Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor
    Shyhmin Huang
    Department of Human Oncology, University of Wisconsin School of Medicine and Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI 53792 0600, USA
    Cancer Res 64:5355-62. 2004
    ..This approach suggests potential new strategies to maximize effective target inhibition, which may improve the therapeutic ratio for anti-EGFR-targeted therapies in developing clinical trials...
  37. doi Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes
    Eric J Moore
    Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Laryngoscope 119:2156-64. 2009
    To investigate the feasibility of transoral robotic surgery as a method of surgical treatment of oropharyngeal squamous cell carcinoma.
  38. pmc Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis
    Wei He
    Department of Oncology, The First Affiliated Hospital of Zhengzhou University, PR China
    BMC Cancer 9:426. 2009
    ..That HIWI expression has been detected in several type tumours may suggest its association with clinical outcome in cancer patients...
  39. pmc Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients
    Waseem Jerjes
    UCLH Head and Neck Centre, London, UK
    Head Neck Oncol 2:9. 2010
    The incidence of oral squamous cell carcinoma remains high. Oral and oro-pharyngeal carcinomas are the sixth most common cancer in the world...
  40. pmc miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)
    N Kikkawa
    Department of Functional Genomics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Br J Cancer 103:877-84. 2010
    Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive malignancy with one of the worst prognoses among all head and neck cancers...
  41. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
    ..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...
  42. pmc Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
    L M Coussens
    Hormone Research Institute, University of California, San Francisco San Francisco, California 94143 0534, USA
    Genes Dev 13:1382-97. 1999
    ....
  43. ncbi High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma
    Lisa Licitra
    Head and Neck Cancer Medical Oncology Unit, Medical Statistics and Biometry, Department of Head and Neck Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Clin Oncol 24:5630-6. 2006
    ..To which extent the viral integration by itself, and/or the associated wild-type (wt) TP53 status, and/or a functional p16 contribute to prognosis is unclear...
  44. ncbi Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
    Head and neck squamous cell carcinoma (HNSCC) cell lines are important preclinical models in the search for novel and targeted therapies to treat head and neck cancer...
  45. ncbi Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
    Marshall R Posner
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 357:1705-15. 2007
    ....
  46. ncbi Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma
    Anak Iamaroon
    Department of Odontology and Oral Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand 50200
    J Oral Pathol Med 32:195-9. 2003
    Although mast cells (MCs) have been implicated in promoting angiogenesis in some malignant tumors, especially of the aerodigestive tract, little is known in oral squamous cell carcinoma (SCC).
  47. ncbi Elevation of preoperative serum C-reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma
    Hideaki Shimada
    Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Surg Oncol 83:248-52. 2003
    ..The aim of this study was to analyze the clinicopathological significance and the prognostic value of preoperative CRP levels in patients with esophageal squamous cell carcinomas...
  48. ncbi Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
    John C Sok
    Department of Otolaryngology, and University of Pittsburgh Cancer Institute Biostatistics, University of Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 12:5064-73. 2006
    Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinoma (HNSCC) where expression levels correlate with decreased survival...
  49. doi Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer
    Johan Bussink
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Netherlands
    Lancet Oncol 9:288-96. 2008
    ..Thus, the activation status of this pathway might be a key element for the prediction of treatment response and for therapeutic targeting in head and neck cancer...
  50. ncbi Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    J Rubin Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine, and University of Pittsburgh Cancer Institute, PA, USA
    J Natl Cancer Inst 90:824-32. 1998
    The most accurate predictor of disease recurrence in patients treated for head and neck squamous cell carcinoma is, at present, the extent of regional lymph node metastasis...
  51. ncbi Oral squamous cell carcinoma: review of prognostic and predictive factors
    João Massano
    Faculty of Medicine, University of Coimbra, Coimbra University Hospital, Coimbra, Portugal
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:67-76. 2006
    Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome...
  52. pmc Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack
    Miroslaw J Szczepanski
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Res 69:3105-13. 2009
    ..To evaluate the role of TLR in tumor cells, we investigated TLR4 signaling effects on human head and neck squamous cell carcinoma (HNSCC). Tumor tissues were obtained from 27 patients with laryngeal and 12 with oral cavity cancers...
  53. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
    ..However, the mechanism(s) by which miR-7 suppresses tumorigenesis in TSCC (tongue squamous cell carcinoma) is unknown...
  54. ncbi Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
    ..To hasten the reduction of HPV-16 prevalence in the population, widespread vaccination of adolescent and young adult males should also be considered...
  55. pmc Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781
    Joel Tepper
    Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7512, USA
    J Clin Oncol 26:1086-92. 2008
    ..To this end, we compared survival, response, and patterns of failure of trimodality therapy to esophagectomy alone in patients with nonmetastatic esophageal cancer...
  56. doi Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]
    J Simon W Stewart
    Charing Cross Hospital, London, UK
    J Clin Oncol 27:1864-71. 2009
    To compare survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) treated with gefitinib 250 or 500 mg/day or standard methotrexate.
  57. pmc Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma
    Geoffrey Childs
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 174:736-45. 2009
    ..In this study, miRNA expression profiles of head and neck squamous cell carcinoma (HNSCC) tumor and adjacent normal tissue were examined by microarray analysis and validated by ..
  58. ncbi Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
    Feng Gu
    Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, P R China
    Oncol Rep 23:671-6. 2010
    Cisplatin is the most important chemotherapeutic agent involved in treatment of head and neck squamous cell carcinoma (HNSCC), but cisplatin resistance in HNSCC is still a serious problem in clinic...
  59. ncbi Cervical cancer
    Steven E Waggoner
    Section of Gynecologic Oncology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Lancet 361:2217-25. 2003
    ..Treatment of recurrent cervical cancer remains largely ineffective. Quality of life should be taken into account in treatment of women with primary and recurrent cervical cancer...
  60. ncbi RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage
    Alexey Fomenkov
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 3:1285-95. 2004
    ..that the genotoxic stress agents induced a dramatic decrease and phosphorylation of DeltaNp63alpha in squamous cell carcinoma cells...
  61. ncbi Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma
    Juan Carlos de Vicente
    Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain
    Oral Oncol 41:283-93. 2005
    ..Ethanol could enhance the carcinogenetic process in oral cavity through its influence in the expression of MMP-2 and -9...
  62. ncbi Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma
    Antonio Rosato
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Int J Cancer 119:1717-22. 2006
    ..Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantly less than that of patients with low survivin ..
  63. ncbi Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene
    Eva María Otero-Rey
    Oral Surgery and Oral Medicine Unit, University of Santiago de Compostela, Spain
    Oral Oncol 44:193-9. 2008
    ..The present study, using expression profiling by cDNA array analysis of oral squamous cell carcinoma cells, identified the V-ATPase system as a significant regulatory mechanism...
  64. ncbi Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based the
    Jan B Vermorken
    Department of Medical Oncology, University Hospital Antwerpen, Edegem, Belgium
    J Clin Oncol 25:2171-7. 2007
    ..receptor-directed monoclonal antibody cetuximab administered as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) who experience disease progression on platinum therapy.
  65. doi Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, Tamagata, Japan
    Pathol Int 58:477-82. 2008
    ..The present results suggest that the majority of penile squamous cell carcinomas in Japanese men are unrelated to HPV, and gene alterations accumulate more frequently in HPV-unrelated penile carcinomas...
  66. doi Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Clin Oncol 27:1992-8. 2009
    ....
  67. doi Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma
    Marilena Vered
    Institute of Pathology Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
    Int J Cancer 127:1356-62. 2010
    ..of immunohistochemical markers of epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) and metastatic tumors to regional lymph nodes (RLNs)...
  68. doi LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix
    Håkan Hedman
    Department of Radiation Sciences, Umea University, Umea, Sweden
    Acta Oncol 49:812-5. 2010
    ..In early stage uterine cervical carcinoma, expression of LRIG1 is associated with good survival. Less is known about the function and expression of LRIG2; it has not been studied in cervical carcinoma, previously...
  69. doi Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles
    Fumiaki Tanaka
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Gut 59:1457-64. 2010
    Oesophageal squamous cell carcinoma (OSCC) is considered a difficult cancer to cure. The detection of environmental and genetic factors is important for prevention on an individual basis.
  70. doi Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma
    Chunni Zhang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 56:1871-9. 2010
    Sensitive and specific biomarkers for the early detection of esophageal squamous cell carcinoma (ESCC) are urgently needed to reduce the high morbidity and mortality of the disease...
  71. ncbi Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    D M Aebersold
    Department of Radiation Oncology, University of Bern, Switzerland
    Cancer Res 61:2911-6. 2001
    ....
  72. ncbi Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma
    Debra Ting Hsiung
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:108-14. 2007
    Head and neck squamous cell carcinoma (HNSCC) is commonly associated with tobacco and alcohol exposures, although dietary factors, particularly folate, and human papillomavirus, are also risk factors...
  73. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
    Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC). To identify microRNAs associated with HNSCC metastasis, six paired HNSCC cell lines with different metastatic potential were examined...
  74. pmc Inhibitor of differentiation 1 contributes to head and neck squamous cell carcinoma survival via the NF-kappaB/survivin and phosphoinositide 3-kinase/Akt signaling pathways
    Jizhen Lin
    Department of Otolaryngology, Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 16:77-87. 2010
    A key issue in cancer is apoptosis resistance. However, little is known about the transcription factors that contribute to cellular survival of head and neck squamous cell carcinoma (HNSCC).
  75. pmc Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Cancer 127:505-12. 2010
    Tumor metastasis is the dominant cause of death in cancer patients, including patients with oral tongue squamous cell carcinoma (TSCC)...
  76. doi Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma
    Angela Stokes
    Biomedical Research Centre, University of East Anglia
    Clin Cancer Res 16:2022-35. 2010
    ..Proteinases have been implicated in several aspects of tumor growth and metastasis in a broad range of tumors including HNSCC...
  77. ncbi BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma
    Apostolos Zaravinos
    Laboratory of Virology, Medical School, University of Crete, Heraklion, Crete, Greece
    Cell Cycle 8:1402-8. 2009
    ..keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential to progress to squamous cell carcinoma (SCC)...
  78. ncbi Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung
    Seong Ho Yoo
    Department of Pathology, Seoul National University College of Medicine, Chongno Gu Yongon Dong 28, Seoul, South Korea
    Lung Cancer 42:195-202. 2003
    ..These results indicate differential biological functions of caveolin-1 depending on the development and progression stage of cancer in vivo...
  79. ncbi Epidermal growth factor receptor biology in head and neck cancer
    Shailaja Kalyankrishna
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Oncol 24:2666-72. 2006
    ..factor receptor (EGFR) is overexpressed in several epithelial malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits EGFR overexpression in up to 90% of tumors...
  80. doi Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis
    Chunping Yu
    State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong 510060, People s Republic of China
    Carcinogenesis 30:894-901. 2009
    ..However, the functional significance of AEG-1 in human esophageal squamous cell carcinoma (ESCC) remains unknown...
  81. ncbi The epidemiology of UV induced skin cancer
    B K Armstrong
    Cancer Research and Registers Division, New South Wales Cancer Council, PO Box 572, Kings Cross 2011, Australia
    J Photochem Photobiol B 63:8-18. 2001
    There is persuasive evidence that each of the three main types of skin cancer, basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma, is caused by sun exposure...
  82. pmc The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus
    G O Elpek
    Department of Pathology, Akdeniz University, Medical School, Dekanlik, 07070 Antalya, Turkey
    J Clin Pathol 54:940-4. 2001
    ..between intratumoral neovascularisation, as assessed by microvessel density (MVD), and prognosis in squamous cell carcinoma (SCC) of the oesophagus...
  83. ncbi 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation
    Shu Hang Ng
    Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan
    J Nucl Med 46:1136-43. 2005
    Accurate evaluation of primary tumors and cervical lymph node status of squamous cell carcinoma (SCC) of the oral cavity is important to treatment planning and prognosis prediction...
  84. ncbi INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy
    Bruce D Minsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:1167-74. 2002
    ..To compare the local/regional control, survival, and toxicity of combined-modality therapy using high-dose (64.8 Gy) versus standard-dose (50.4 Gy) radiation therapy for the treatment of patients with esophageal cancer...
  85. ncbi Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression
    Qiang Huang
    Department of Otolaryngology, The New York Eye and Ear Infirmary, New York Medical College, New York, New York 10003, USA
    Genes Chromosomes Cancer 34:224-33. 2002
    For a better understanding of genetic alterations in head and neck squamous cell carcinoma (HNSCC), we applied comparative genomic hybridization (CGH) in the analysis of 75 HNSCCs, comprised of 18 pharyngeal squamous cell carcinomas (..
  86. ncbi Molecular cytogenetic analysis of head and neck squamous cell carcinoma: By comparative genomic hybridization, spectral karyotyping, and expression array analysis
    Jeremy A Squire
    Department of Laboratory Medicine and Pathobiology, The University of Toronto and The University Health Network, Toronto, Ontario, Canada
    Head Neck 24:874-87. 2002
    A combination of molecular cytogenetic and expression array analysis has been performed on head and neck squamous cell carcinoma (HNSCC) of the oral cavity and supraglottis...
  87. ncbi Mutations of the BRAF gene in squamous cell carcinoma of the head and neck
    Anette Weber
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Liebigstrasse 18a, 04103 Leipzig, Germany
    Oncogene 22:4757-9. 2003
    ..This study was performed to elucidate a possible function of BRAF in squamous cell carcinoma of the head and neck (HNSCC)...
  88. ncbi The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
    ..b>Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of ..
  89. pmc MicroRNA alterations in head and neck squamous cell carcinoma
    Steven S Chang
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0910, USA
    Int J Cancer 123:2791-7. 2008
    ..Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC)...
  90. doi Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 115:1489-97. 2009
    Tumor thickness (TT) appears to be a strong predictor for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity (OSCC), but a precise clinically optimal TT cutoff point has not been established...
  91. pmc TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma
    M E Kupferman
    Department of Head and Neck Surgery, Houston TX, USA
    Oncogene 29:2047-59. 2010
    Head and neck squamous cell carcinoma (HNSCC) remains a significant public health problem, accounting for over 5% of all cancer-related deaths, and these deaths primarily result from metastatic disease...
  92. pmc ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage
    Yiping Huang
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell Cycle 7:2846-55. 2008
    ..Our results implicate specific kinases, and target phosphorylation sites in the degradation of Delta Np63 alpha following DNA damage...
  93. ncbi Clinical significance of serum vascular endothelial growth factor in esophageal squamous cell carcinoma
    H Shimada
    Department of Academic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba, Japan
    Cancer 92:663-9. 2001
    ..The objective of the current study was to determine the correlation between pretreatment S-VEGF and clinicopathologic features in patients with esophageal squamous cell carcinoma.
  94. ncbi Oral cancer and precancerous lesions
    Brad W Neville
    Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, USA
    CA Cancer J Clin 52:195-215. 2002
    ..The purpose of this article is to review the clinical features of oral cancer and premalignant oral lesions, with an emphasis on early detection...
  95. ncbi Cyclin D1, E2F1 expression levels are associated with characteristics and prognosis of esophageal squamous cell carcinoma
    S Mega
    Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
    Dis Esophagus 18:109-13. 2005
    ..We performed a multi-institutional analysis of E2F1 and cyclin D1 expression in cases of esophageal squamous cell carcinoma (ESCC)...
  96. ncbi Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand
    Suparp Kietthubthew
    Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
    Int J Hyg Environ Health 209:21-9. 2006
    ..We investigated associations between polymorphisms in DNA repair genes and oral squamous cell carcinoma (OSCC) in a Thai population...
  97. ncbi Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
    ..The generation of these tracks by fibroblasts is sufficient to enable the collective invasion of the squamous cell carcinoma (SCC) cells and requires both protease- and force-mediated matrix remodelling...
  98. ncbi [Expression and clinical significance of HMGB1 and RAGE in cervical squamous cell carcinoma]
    Quan Hao
    Department of Gynecology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
    Zhonghua Zhong Liu Za Zhi 30:292-5. 2008
    To investigate the association between high mobility group box1 (HMGB1) and cervical squamous cell carcinoma (CSCC), and explore the role of HMGB1/RAGE pathway in the metastasis of CSCC.
  99. doi Increasing trend of the incidence of esophageal squamous cell carcinoma, but not adenocarcinoma, in Taiwan
    Ching Liang Lu
    Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
    Cancer Causes Control 21:269-74. 2010
    ..We examined temporal trends in the incidence of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA) in Taiwan...
  100. doi Nerve growth factor and tyrosine kinase A receptor in oral squamous cell carcinoma: is there an association with perineural invasion?
    Antonia Kolokythas
    Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago College of Dentistry, Chicago, IL, USA
    J Oral Maxillofac Surg 68:1290-5. 2010
    Perineural invasion (PNI) in oral squamous cell carcinoma (SCC) is recognized as a significant predictor of outcome. PNI is associated with locoregional recurrence and decreased survival of patients with head and neck SCC...
  101. pmc Oncolytic vaccinia therapy of squamous cell carcinoma
    Zhenkun Yu
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mol Cancer 8:45. 2009
    ..We examined the therapeutic effects of an attenuated, replication-competent vaccinia virus (GLV-1h68) as an oncolytic agent against a panel of six human head and neck SCC cell lines...

Research Grants79

  1. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..has an increased chance of developing one of the forms of skin cancer, including basal cell carcinoma, squamous cell carcinoma and cutaneous malignant melanoma...
  2. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    Project Summary/Abstract Tobacco and alcohol use and genetic susceptibility are major risk factors for squamous cell carcinoma of the head and neck (SCCHN)...
  3. Tatiana Efimova; Fiscal Year: 2014
    ..Epithelial cancers, or carcinomas, comprise over 90% of all human cancers. Cutaneous squamous cell carcinoma (SCC) is the second most common cancer in the United States that exhibits poor prognosis in advanced ..
  4. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Head and neck squamous cell carcinoma (HNSCC) is the ninth most common cancer worldwide. In the US there are 40-50,000 new cases a year and ~12,000 deaths due to HNSCC...
  5. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..scientist by studying hormone and growth factors and their role in the development and pathobiology of squamous cell carcinoma (SCC) in order to support a career in academia and biomedical research. Dr...
  6. Vernon K Sondak; Fiscal Year: 2016
    ..4: Prospective Study of the Associations between Cutaneous Papillomavirus and Polyomavirus Infections and Squamous Cell Carcinoma 27 CORE A: Tissue, Pathology and Bioinformatics Core 33 CORE B: Biostatistics Core 36 CORE C: ..
  7. Cong Yan; Fiscal Year: 2014
    ..for human lung cancer samples, Stat3 up-regulation was highly associated with adenocarcinoma and squamous cell carcinoma. Therefore, Stat3 and its downstream genes can be used as biomarkers for lung cancer diagnosis in animals ..
  8. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..More than 90% of head and neck malignancies are squamous cell carcinoma (SCC), originating from the epithelium which lines the UADT...
  9. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that is treated aggressively when diagnosed at late stages...
  10. Edward A Neuwelt; Fiscal Year: 2015
    ..cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) variants H460 large cell carcinoma, H520 squamous cell carcinoma, and A549 adenocarcinoma...
  11. Integrative Pathway Analysis of Epigenomic/transcriptional Alteration in HNSCC
    Joseph A Califano; Fiscal Year: 2010
    ..frequently activate candidate proto-oncogenes and tumor specific cancer testes antigens in head and neck squamous cell carcinoma (HNSCC)...
  12. Wei Xing Zong; Fiscal Year: 2016
    ..We also reported that an endogenous serine/cysteine protease inhibitor SerpinB3 (also termed squamous cell carcinoma antigen 1, SCCA1) may function as a molecular signature for predicting efficacy with proteotoxicity-based ..
  13. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz-Martin; Fiscal Year: 2012
    ..studies in mouse keratinocyte models and have preliminarily confirmed this association in human squamous cell carcinoma (SCC)...
  14. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..There are two histologic types of esophageal cancer;squamous cell carcinoma (SCC) and adenocarcinoma...
  15. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..Interestingly, the incidence of head and neck squamous cell carcinoma (HNSCC) has been shown to correlate with dental hygiene, which may suggest the relevance of bacteria in ..
  16. Lorraine J Gudas; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide [1]...
  17. FUNCTION OF THE RAS RELATED RAL PROTEINS
    LARRY FEIG; Fiscal Year: 2009
    ..a bioengineered model of human skin, we found that RalA plays a cell-type dependent role in Ras-mediated squamous cell carcinoma. In keratinocytes of the epithelium, RalA inhibits tumorigenesis, since suppression of RalA expression ..
  18. Ajit K Verma; Fiscal Year: 2015
    ..whether protein kinase C epsilon (PKC5) signals ultraviolet radiation (UVR)-induced development of squamous cell carcinoma (SCC) via increased expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF1) and ..
  19. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..Third, ?Np63 is found to be amplified and/or over-expressed in some tumors, such as head and neck squamous cell carcinoma, and correlated with tumor progression and poor prognosis...
  20. Richard F Selden; Fiscal Year: 2014
    ..Dean, and the molecular biological and microfluidic expertise of Dr. Selden, the application provides a unique collaborative opportunity to finally obtain a rapid nucleic-acid based POC diagnostic for C. trachomatis. ..
  21. Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    David T Woodley; Fiscal Year: 2010
    ..Patients with RDEB die of an aggressive, metastatic, squamous cell carcinoma in the second or third decade of life...
  22. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..imaging during Mohs surgery, and to test feasibility for detecting basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) margins on patients, using aluminum chloride as a contrast agent for staining nuclear morphology in ..
  23. Function of the Ras Related Ral Protein
    LARRY FEIG; Fiscal Year: 2013
    ..We found that RalA plays a cell-type dependent role in Ras-mediated squamous cell carcinoma. In keratinocytes of the epithelium, RalA inhibits, rather than supports tumorigenesis, since suppression ..
  24. Robert L Ferris; Fiscal Year: 2014
    ..monoclonal antibody (mAb), cetuximab, is effective therapy only for a subset of advanced head and neck squamous cell carcinoma (HNC). Thus, there is a need to understand why clinical responses vary between individuals...
  25. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer. Its incidence increased 60% recently in adults age 40 or less...
  26. Yvonne L Kapila; Fiscal Year: 2014
    ..In oral/head and neck squamous cell carcinoma (HNSCC), anoikis resistance induces more aggressive tumors...
  27. Steven P Stratton; Fiscal Year: 2015
    ..e. actinic keratosis, squamous cell carcinoma in situ) and dramatically reduce the risk of squamous cell carcinoma of the skin...
  28. KARAM E EL-BAYOUMY; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Oral squamous cell carcinoma (OSCC) is the most common cancer of the head and neck region;in the USA, over 45,000 cases and about 11,000 deaths from the disease occur annually...
  29. Stacey L Halum; Fiscal Year: 2014
    ..such as controlling respiratory papillomatosis recurrence, providing adjuvant therapy for laryngeal squamous cell carcinoma, or augmenting vocal folds in presbylaryngis...
  30. Hyeong Reh Choi Kim; Fiscal Year: 2014
    ..is to gain scientific knowledge that can be used to improve outcome in patients with head and neck squamous cell carcinoma (HNSCC)...
  31. Dysregulation of microRNAs in HPV-Positive Oropharyngeal Cancers
    Abigail Wald; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Every year, there are more than 45,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) in the United States and 500,000 new cases woridwide...
  32. Jakub Tolar; Fiscal Year: 2016
    ..joint contractures, and strictures of the esophagus, with opportunistic infections and aggressive squamous cell carcinoma as principal causes of early death...
  33. SPORE in Skin Cancer
    Meenhard Herlyn; Fiscal Year: 2009
    ..This SPORE is focused on major skin cancers: melanoma, cutaneous T cell lymphoma (CTCL) and squamous cell carcinoma (SCC)...
  34. Proteomic Approach for Early Detection of Head and Neck Cancer
    Ho Sheng Lin; Fiscal Year: 2012
    ..and therapeutic modalities, long-term prognosis for patients affected by advanced stage head and neck squamous cell carcinoma (HNSCC) remains dismal with 5-year survival less than 40%...
  35. June K Robinson; Fiscal Year: 2014
    ..the requisite life-long immunosuppressive therapy is associated with developing skin cancer, especially squamous cell carcinoma (SCC) and malignant melanoma (MM)...
  36. M ALANNA RUDDELL; Fiscal Year: 2014
    ..sinus growth and increased lymph flow which precede and predict metastasis in murine models of melanoma, squamous cell carcinoma, and lymphoma. These TDLN alterations could actively promote tumor dissemination via the lymphatics...
  37. Role of MicroRNA 363 in HPV-positive oral cancer
    Saleem A Khan; Fiscal Year: 2013
    ..been a substantial increase in the incidence of human papillomavirus (HPV)-associated oropharyngeal (OP) squamous cell carcinoma (OPSCC), while other cases result from alcohol and/or tobacco use...
  38. Shulin Li; Fiscal Year: 2014
    b>Squamous cell carcinoma (SCC) is the most common type of cancer affecting the oral cavity, the head, and neck, and is the fourth most common malignancy in male humans...
  39. Small Interfering RNAs: Inhibition of Oral Carcinogenesis in a Mouse Model
    Lorraine J Gudas; Fiscal Year: 2010
    b>Squamous cell carcinoma (SCC) of the oral cavity is one of the most common cancers in the world. The long-term survival rate for this cancer is only about 50%...
  40. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..various skin diseases described above, as well as epithelial cell skin cancers, including head and neck squamous cell carcinoma (HNSCC)...
  41. Wendy B Bollag; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The non-melanoma skin cancers (NMSCs), basal and squamous cell carcinoma, are the most common cancers, occurring more often than all cancers combined, with approximately 1 million new cases diagnosed ..
  42. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    ..Our preliminary data show that the human La protein is overexpressed in squamous cell carcinoma (SCC) tissue of the oral cavity and strongly suggest that La is involved in proliferation, migration, and ..
  43. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2012
    Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer related death worldwide...
  44. Carolyn J Anderson; Fiscal Year: 2014
    ..provided by applicant): Metastasis to the regional lymph nodes occurs in about 60% of patients with squamous cell carcinoma of the head and neck (SCCHN) [1] and is the most important indicator of disease prognosis and outcome...
  45. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2013
    Tobacco and alcohol use and genetic susceptibility are major risk factors for squamous cell carcinoma of the head and neck (SCCHN)...
  46. Supriya Gangadharan Prasanth; Fiscal Year: 2016
    ..1 in human cells, a region that is frequently amplified in esophageal squamous cell carcinoma or shows rearrangements and loss of heterozygosity in myelodysplasia and acute leukemia...
  47. Regulation of Invasion and Metastasis by HIF-1 Oral Squamous Cell Carcinoma
    Stephen Y Lai; Fiscal Year: 2010
    Project Summary: Resistance to treatment has been a vexing challenge for oral squamous cell carcinoma (OSCC). Within the tumor microenvironment, OSCC cells rapidly expend oxygen and nutrients supplied by the local vasculature...
  48. Importance of Gender in the Chemoprevention of UV induced Skin Cancer
    Tatiana M Oberyszyn; Fiscal Year: 2013
    ..skin cancer (NMSC) with men being as twice as likely to develop NMSC and three times as likely to develop squamous cell carcinoma as women...
  49. Fanconi Anemia and HPV Transformation
    Susanne I Wells; Fiscal Year: 2013
    ..that have undergone a bone marrow transplant continue to be at high risk for anogenital and head and neck squamous cell carcinoma (SCC), suggesting that the FA pathway functions to prevent epithelial cell transformation...
  50. Biomarkers for Esophageal Cancer Progression and Prognosis
    Tony E Godfrey; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Esophageal cancer occurs in two major histologic types;squamous cell carcinoma (SCC) and adenocarcinoma (EA) both of which have an extremely poor prognosis...
  51. Protein Kinase D and Epidermal Structure and Function
    Wendy B Bollag; Fiscal Year: 2010
    The non-melanoma skin cancers (NMSCs), basal and squamous cell carcinoma are the most common cancers, with approximately 1 million new cases diagnosed per year...
  52. Hamid Ghandehari; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Head and neck squamous cell carcinoma (HNSCC) is an ominous cancer with more than 48,000 new cases diagnosed annually in the US...
  53. Genetic and Epigenetic Biomarkers for SCC of the Lung
    Steven A Belinsky; Fiscal Year: 2012
    ..In Aim 3 a nested, case-control study of squamous cell carcinoma (SCC) will be conducted in 1440 radon-exposed uranium miners...
  54. CENTER FOR CANCER BIOLOGY RESEARCH
    W Keith Miskimins; Fiscal Year: 2011
    ..MD) will focus on the role of the immune response in tumor clearance following treatment of head and neck squamous cell carcinoma. A strong mentoring plan will take advantage of the experience of an outstanding group of senior faculty ..
  55. Lizandra Jimenez; Fiscal Year: 2014
    ..global expression patterns of miRNAs in both tumor and normal samples from patients with head and neck squamous cell carcinoma (HNSCC);we identified miR-375 as the most consistently down-regulated miRNA in tumor samples when ..
  56. FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    Yvonne Kapila; Fiscal Year: 2009
    ..V+H-) containing a mutated heparin-binding domain and the V region of FN induces apoptosis of squamous cell carcinoma (SCC) cells...
  57. Cigarette Smoking among Head and Neck Cancer Patients: A Prospective Study
    JESSICA LYNN BURRIS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Behavioral research with head and neck squamous cell carcinoma (HNSCC) patients is high priority. The etiology of HNSCC is linked to the health risk behaviors of tobacco and alcohol consumption...
  58. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung cancer accounts for the majority of cancer mortality. Lung squamous cell carcinoma (SCC) accounts for 30% of lung cancer cases, thus the need for further knowledge about prevention and treatment ..
  59. The alpha 2 beta 1 Integrin: Innate Immunity to Pathogens &Tumors
    Mary M Zutter; Fiscal Year: 2013
    ..In this model, invasive squamous cell carcinoma occurs in 50% of wild type mice. We generated K14-HPV16/WT and HPV16/2-null mice...
  60. Epigenetic Changes in Retinoid Signaling in Oral Cavity Carcinogenesis
    KATARZYNA MARIA MARCINKIEWICZ; Fiscal Year: 2013
    ..regulatory and chromatin remodeling proteins that show altered expression in human head and neck squamous cell carcinoma (HNSCC)...
  61. Madhavi P Kadakia; Fiscal Year: 2016
    ..The rise in the incidence of non-melanoma skin cancers (NMSCs), namely Basal cell carcinoma (BCC) and Squamous cell carcinoma (SCC), and growing cost of treatment warrants research into the basic etiologies of these cancers in ..
  62. STEVEN ALAN ROSENZWEIG; Fiscal Year: 2016
    ..We have shown that in head and neck squamous cell carcinoma (HNSCC) cells IGF1R activation increases vascular endothelial growth factor (VEGF) synthesis and ..
  63. VIP AND EGF RECEPTORS IN NON-SMALL CELL LUNG CANCER
    Terry Moody; Fiscal Year: 1991
    ..tumor which responds to chemo- and/or radiation therapy, adenocarcinoma, large cell carcinoma and squamous cell carcinoma. We found that SCLC produces bombesin-like peptides, which function as autocrine growth factors...
  64. Prevention of Head and Neck Carcinogenesis with a Plant-Derived Compound
    Rebecca Leeman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project Summary: Head and neck squamous cell carcinoma (HNSCC) is thought to be caused by the effects of environmental carcinogens including tobacco, alcohol, betel quid, organic solvents, coal dust, ..
  65. Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
    John T McDevitt; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Oral cancer, largely oral squamous cell carcinoma (OSCC), is a global health problem afflicting close to 300,000 people each year...
  66. EGFR antisense DNA added to cetuximab and radiotherapy for head and neck cancer
    Athanassios Argiris; Fiscal Year: 2009
    The epidermal growth factor receptor (EGFR) is upregulated in squamous cell carcinoma of the head and neck (SCCHN) and has been associated with poor prognosis...
  67. Early Diagnosis of Oral Carcinoma Using Mutant PP32R1
    GERALD KOCHEVAR; Fiscal Year: 2006
    Most oral leukoplakic lesions represent hyperkeratotic epithelium (benign), dysplasia, or squamous cell carcinoma. The lesions must be biopsied and examined microscopically for diagnosis...
  68. ErbB1 signaling and cancer-mediated diseases of bone
    John Foley; Fiscal Year: 2006
    ..Over 57,000 (38% of the total) new cases will be a form of the disease called squamous cell carcinoma of which (approximately 90%) appear to be a consequence of smoking...
  69. Discovery of Alpha-MSH Analogs for Skin Cancer Prevention
    Zalfa Abdel Malek; Fiscal Year: 2009
    Skin cancer, in the form of melanoma, basal or squamous cell carcinoma, is the most commonformof cancer in the U.S.A. and is mainly caused by sun exposure, which results in DNA damage and photocarcinogenesis...
  70. Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma
    Norma Nowak; Fiscal Year: 2009
    Approximately 500,000 new cases of head and neck squamous cell carcinoma (HNSCC), including the oral cavity, pharynx and larynx, are reported each year...
  71. Chemoprevention of Photocarcinogenesis by Resveratrol
    Nihal Ahmad; Fiscal Year: 2003
    ..This may pave the way for the development of novel strategies for prevention and possibly treatment of skin cancer and other epithelial cancers as well. ..
  72. Effect of Oral Lactoferrin on Head and Neck Carcinoma
    Jeffrey Wolf; Fiscal Year: 2006
    b>Squamous cell carcinoma of the head and neck affects 50,000 new cases in the United States each year. It is a debilitating and frequently disfiguring affliction that is in need of better treatment modalities...
  73. Identification of Metastasis-related Gene in Oral Cancer
    Zhuo Chen; Fiscal Year: 2004
    ..methods for whole-genome functional analysis will be used to identify metastasis-related genes in oral squamous cell carcinoma (SCC) in a novel lymph nodal metastatic mouse model...
  74. NEOADJUVANT THERAPY OF OR CANCER BY INHIBITING NF-KAPPAB
    Cun Yu Wang; Fiscal Year: 2003
    Oral cancer typically presents as a very malignant tumor. More than 90 percent of oral cancers are squamous cell carcinoma which also is one of the most common malignant types occurring lung, skin, and ovary...
  75. Etiologic Role of HPV in Keratinocyte Carcinomas
    Margaret Karagas; Fiscal Year: 2009
    ..e., squamous cell carcinoma (SCC) of the skin) is unclear...