carcinoma in situ

Summary

Summary: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.

Top Publications

  1. pmc The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:258-62. 2003
  2. ncbi Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    Carmen Guerra
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Cancer Cell 11:291-302. 2007
  3. ncbi Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors
    Uwe M Galli
    Department of Virology, Bldg 47, University of Saarland Medical School, 66421 Homburg Saar, Germany
    Oncogene 24:3223-8. 2005
  4. ncbi Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification
    Lars Dyrskjøt
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Cancer Res 64:4040-8. 2004
  5. doi Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer
    Cathy B Moelans
    Department of Pathology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    J Pathol 225:222-31. 2011
  6. ncbi Consistent high viral load of human papillomavirus 16 and risk of cervical carcinoma in situ: a nested case-control study
    N Ylitalo
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Lancet 355:2194-8. 2000
  7. pmc Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24
    D Craig Allred
    National Surgical Adjuvant Breast and Bowel Project, Washington University School of Medicine, Department of Pathology and Immunology, 660 Euclid Campus Box 8118, St Louis, MO 63110, USA
    J Clin Oncol 30:1268-73. 2012
  8. ncbi Pathologic variables predictive of breast events in patients with ductal carcinoma in situ
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    Am J Clin Pathol 128:86-91. 2007
  9. doi Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ
    Elaine S Wai
    Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Center, Victoria, British Columbia, Canada
    Cancer 117:54-62. 2011
  10. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001

Detail Information

Publications397 found, 100 shown here

  1. pmc The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:258-62. 2003
    The term lobular neoplasia refers to a spectrum of lesions featuring atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). The histopathological characteristics of these lesions are well documented...
  2. ncbi Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    Carmen Guerra
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Cancer Cell 11:291-302. 2007
    ..These observations suggest that, during adulthood, PDA stems from a combination of genetic (e.g., somatic K-Ras mutations) and nongenetic (e.g., tissue damage) events...
  3. ncbi Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors
    Uwe M Galli
    Department of Virology, Bldg 47, University of Saarland Medical School, 66421 Homburg Saar, Germany
    Oncogene 24:3223-8. 2005
    ..rec show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma in situ, the predecessor lesion of classic seminoma in humans...
  4. ncbi Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification
    Lars Dyrskjøt
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Cancer Res 64:4040-8. 2004
    The presence of carcinoma in situ (CIS) lesions in the urinary bladder is associated with a high risk of disease progression to a muscle invasive stage...
  5. doi Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer
    Cathy B Moelans
    Department of Pathology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    J Pathol 225:222-31. 2011
    ..to compare the methylation status of 25 breast cancer-related genes between laser-microdissected ductal carcinoma in situ (DCIS) and adjacent invasive ductal cancer (IDC) lesions in 33 breast cancer patients...
  6. ncbi Consistent high viral load of human papillomavirus 16 and risk of cervical carcinoma in situ: a nested case-control study
    N Ylitalo
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Lancet 355:2194-8. 2000
    ..Persistence may depend on certain characteristics, such as viral load, which has so far been given little attention. We investigated the association between HPV 16 viral load and cervical carcinoma in situ.
  7. pmc Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24
    D Craig Allred
    National Surgical Adjuvant Breast and Bowel Project, Washington University School of Medicine, Department of Pathology and Immunology, 660 Euclid Campus Box 8118, St Louis, MO 63110, USA
    J Clin Oncol 30:1268-73. 2012
    ..Bowel Project) B-24 study demonstrated significant benefit with adjuvant tamoxifen in patients with ductal carcinoma in situ (DCIS) after lumpectomy and radiation. Patients were enrolled without knowledge of hormone receptor status...
  8. ncbi Pathologic variables predictive of breast events in patients with ductal carcinoma in situ
    Edwin R Fisher
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
    Am J Clin Pathol 128:86-91. 2007
    Central pathology review of ductal carcinoma in situ from 1,456 patients enrolled in National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-24 was performed to determine predictors for ipsilateral breast tumor recurrences ..
  9. doi Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ
    Elaine S Wai
    Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Center, Victoria, British Columbia, Canada
    Cancer 117:54-62. 2011
    ..for patients with invasive breast cancer, but whether this is applicable to patients with pure ductal carcinoma in situ (DCIS) is unclear...
  10. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
    ....
  11. ncbi Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways
    Gillian Farnie
    Department of Surgery and Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, M20 9BX, Manchester, UK
    J Natl Cancer Inst 99:616-27. 2007
    ..We investigated the involvement of these signaling pathways in ductal carcinoma in situ (DCIS) of the breast.
  12. pmc Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ
    Michael Christie
    Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Int J Clin Exp Pathol 3:629-33. 2010
    ..We report a case of primary small cell carcinoma of the breast with coexisting carcinoma in situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid ..
  13. doi Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Breast Cancer Res Treat 113:59-66. 2009
    ..The aim of this study is to assess the expression of these genes in LCIS and compare them with normal breast, using CDH1 as a control, in order to evaluate their role as TSGs...
  14. pmc Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection
    Julie Steinestel
    Department of Urology, University of Ulm, Ulm, Germany
    PLoS ONE 8:e65189. 2013
    ..a surrogate marker for infection with oncogenic HPV in other tumours, has been described for urothelial carcinoma in situ (UCIS)...
  15. ncbi The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
    Teresa M Darragh
    Departments of Pathology and Obstetrics, Gynecology and Reproductive Science, University of California San Francisco Mt Zion Medical Center, 1600 Divisadero St, San Francisco, CA 94115, USA
    Arch Pathol Lab Med 136:1266-97. 2012
    ..The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care...
  16. ncbi Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions
    Malte Buchholz
    Department of Internal Medicine I, University Hospital of Ulm, Germany
    Oncogene 24:6626-36. 2005
    ....
  17. ncbi Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection
    Sergio M Nicolau
    Department of Gynecology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Urology 65:251-5. 2005
    ....
  18. doi Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast
    Matthew W Conklin
    Department of Pharmacology, University of Wisconsin, 1525 Linden Dr, Madison, WI 53706, USA
    Cell Biochem Biophys 53:145-57. 2009
    ..Comparing regions of carcinoma in situ to adjacent histologically normal regions, we found that tumor cells produced higher intensity and had a ..
  19. doi Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial
    Nigel J Bundred
    Department of Academic Surgery, University Hospital of South Manchester, Manchester, United Kingdom
    Clin Cancer Res 16:1605-12. 2010
    Tamoxifen reduces risk of recurrence after breast conservation surgery for ductal carcinoma in situ (DCIS), but no data exists on the effectiveness of aromatase inhibitors for DCIS...
  20. pmc Molecular genetics of pancreatic intraepithelial neoplasia
    Georg Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Ross Bldg 632, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Hepatobiliary Pancreat Surg 14:224-32. 2007
    ..Recent evidence suggests that noninvasive precursor lesions, classified as pancreatic intraepithelial neoplasia (PanIN), can progress to invasive pancreatic cancer. This review will discuss the major genetic alterations in PanIN lesions...
  21. ncbi Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclassification
    J Röwert-Huber
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:8-12. 2007
    ....
  22. ncbi Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    Z T Zhang
    Department of Urology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 20:1973-80. 2001
    ..develop along two distinctive phenotypic pathways (superficial papillary non-invasive tumors versus flat carcinoma in situ lesions), with markedly different biological behavior and prognosis...
  23. pmc KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin
    Chanjuan Shi
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 212312, USA
    Mol Cancer Res 7:230-6. 2009
    ..Isolated AMD lesions are genetically distinct from those associated with PanINs, and the latter may represent retrograde extension of the neoplastic PanIN cells or less likely are precursors to PanIN...
  24. ncbi Trends in the incidence of invasive and in situ vulvar carcinoma
    Patricia L Judson
    Department of Obstetrics, Gynecology and Women s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Obstet Gynecol 107:1018-22. 2006
    To characterize the incidence of vulvar carcinoma in situ and vulvar cancer over time.
  25. ncbi A SAGE (serial analysis of gene expression) view of breast tumor progression
    D A Porter
    Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 61:5697-702. 2001
    ....
  26. doi Ductal carcinoma in situ treated with breast-conserving surgery and radiotherapy: a comparison with ECOG study 5194
    Sabin B Motwani
    Department of Radiation Oncology, The Cancer Institute of New Jersey, NY 08903, USA
    Cancer 117:1156-62. 2011
    ..Cooperative Oncology Group (ECOG) Study 5194 (E5194) prospectively defined a low-risk subset of ductal carcinoma in situ (DCIS) patients where radiation therapy was omitted after lumpectomy alone...
  27. pmc An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ
    Fariba Behbod
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Breast Cancer Res 11:R66. 2009
    ..Ductal carcinoma in situ (DCIS) is the most common type (80%) of noninvasive breast lesions...
  28. doi Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization
    Masahiro Uchida
    Department of Molecular Pathology, Oita University, Oita, Japan
    J Pathol 221:96-105. 2010
    ..extensively characterized by array comparative genomic hybridization (array CGH) analysis, those of gastric carcinoma in situ (CIS) are still poorly understood...
  29. ncbi Fluorescence visualization detection of field alterations in tumor margins of oral cancer patients
    Catherine F Poh
    Faculty of Dentistry, University of British Columbia, Department of Cancer Control Research, and Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Clin Cancer Res 12:6716-22. 2006
    ..Molecular approaches have begun to yield information on cancer/risk fields; tissue optics could further extend our understanding of alteration to phenotype as a result of molecular change...
  30. ncbi Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod Update 12:303-23. 2006
    b>Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male adolescents and young adults...
  31. doi Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis
    A J M Gillis
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Androl 34:e160-74. 2011
    ..LIN28 was also found in all precursor lesions (carcinoma in situ and gonadoblastoma) of type II GCTs, as well as the invasive components seminoma and the non-seminomatous ..
  32. ncbi Precursors to invasive pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Adv Anat Pathol 12:81-91. 2005
    ..Finally, the potential clinical impact of recognizing these precursor lesions in the context of early detection of pancreatic cancer will be discussed...
  33. ncbi Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer
    M J van de Vijver
    Department of Pathology, Netherlands Cancer Institute, Amsterdam
    N Engl J Med 319:1239-45. 1988
    ..We conclude that neu overexpression may be an early step in the development of a distinct histologic type of carcinoma of the breast, but we could find no association of overexpression with lymph-node status or tumor recurrence...
  34. ncbi Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review
    Elizabeth Y Chiao
    Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Michael E DeBakey Veterans Affairs Medical Center, TX, USA
    Clin Infect Dis 43:223-33. 2006
    ..This review identifies important areas for further study before routine anal Pap smear screening can be recommended...
  35. ncbi Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Cancer Res 63:6032-41. 2003
    ..Local immune infiltration may be a critical factor in potential responsiveness to vaccine therapy in HPV-associated neoplasia and should be carefully monitored in future placebo-controlled trials of immunotherapy for VIN...
  36. ncbi Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    David W Kindelberger
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:161-9. 2007
    ....
  37. ncbi Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
    ....
  38. doi Concomitant carcinoma in situ as an independent prognostic parameter for recurrence and survival in upper tract urothelial carcinoma: a multicenter analysis of 772 patients
    Wolfgang Otto
    Caritas St Josef Medical Center, University of Regensburg, Regensburg, Germany
    World J Urol 29:487-94. 2011
    The purpose of this study is to assess the association of concomitant carcinoma in situ (CIS) with disease recurrence and cancer-related death in a multi-institutional series of patients treated with radical nephroureterectomy (RNU) for ..
  39. doi Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications
    J De Jong
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Pathol 215:21-30. 2008
    ..Here we demonstrate that SOX2 is absent in germ cells of human fetal gonads, and as expected carcinoma in situ (CIS), ie the precursor lesion of testicular germ cell tumours of adolescents and adults (TGCTs), and ..
  40. ncbi The role of lymphocytes and macrophages in human breast tumorigenesis: an immunohistochemical and morphometric study
    Herzl Ben-Hur
    Department of Obstetrics and Gynecology, Asaf Haroffeh Hospital, Tserifin, Israel
    Anticancer Res 22:1231-8. 2002
    ..The following types of tumors were studied: 1) fibrocystic disease, 2) fibroadenoma, 3) carcinoma in situ, 4) infiltrating ductal and lobular carcinoma with high lymphoid infiltration, and 5) infiltrating ductal ..
  41. doi Concomitant carcinoma in situ is a feature of aggressive disease in patients with organ confined urothelial carcinoma following radical nephroureterectomy
    Jeffery C Wheat
    University of Michigan, Ann Arbor, MI 48109, USA
    Urol Oncol 30:252-8. 2012
    b>Carcinoma in situ (CIS) is associated with increased risk of progression when found with high-grade non-muscle-invasive bladder cancer, yet its impact is less clear in the upper urinary tract...
  42. pmc Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
    K Almstrup
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Br J Cancer 103:1269-76. 2010
    The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells...
  43. ncbi CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions
    Peter J Barth
    Institute of Pathology, Philipps University, 35033 Marburg, Germany
    Virchows Arch 440:298-303. 2002
    ..setting of the present study the loss of CD34+ fibrocytes was specific for invasive breast cancer and ductal carcinoma in situ, whereas SMA-reactive myofibroblasts were observed in different benign and malignant lesions...
  44. doi Cell discohesion and multifocality of carcinoma in situ of the bladder: new insight from the adhesion molecule profile (e-cadherin, Ep-CAM, and MUC1)
    Carlo Patriarca
    Department of Pathology, Azienda Ospedaliera di Melegnano, and University of Milan Medical School, ICH Humanitas Rozzano, Milan, Italy
    Int J Surg Pathol 17:99-106. 2009
    Urothelial cell carcinoma in situ (CIS) of the bladder is a superficially diffusive and highly discohesive disease...
  45. doi The predictive value of testicular ultrasound abnormalities for carcinoma in situ of the testis in men at risk for testicular cancer
    J E Elzinga-Tinke
    Andrology Unit, Department of Urology, Erasmus MC University Medical Centre Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Int J Androl 33:597-603. 2010
    ..It has been suggested that TM is more prevalent in testes of men at risk for testicular carcinoma in situ (CIS), the precursor cells of all testicular germ cell tumours (TGCT)...
  46. doi Concomitant carcinoma in situ and tumour size are prognostic factors for bladder recurrence after nephroureterectomy for upper tract transitional cell carcinoma
    Enrique Pieras
    Department of Urology, Son Dureta University Hospital, Palma de Mallorca, Baleares Isles, Spain
    BJU Int 106:1319-23. 2010
    ..To identify prognostic risk factors for the development of subsequent bladder recurrence in patients undergoing nephroureterectomy (NU) for upper tract transitional cell carcinoma (TCC)...
  47. ncbi Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
    b>Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men...
  48. pmc Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions
    CATHERINE CARRIERE
    Department of Medicine, Department of Pharmacology, and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gastroenterology 141:1091-101. 2011
    ..To determine the role of loss of RB function in PDAC progression, we investigated the effects of Rb disruption during pancreatic malignant transformation initiated by oncogenic Kras...
  49. doi MicroRNA expression profiling of carcinoma in situ cells of the testis
    Guy Wayne Novotny
    Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Endocr Relat Cancer 19:365-79. 2012
    ..germ cell tumours, seminoma (SE) and non-seminoma (NS), of young adult men develop from a precursor cell, carcinoma in situ (CIS), which resembles foetal gonocytes and retains embryonic pluripotency...
  50. ncbi Improved gene expression signature of testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Androl 30:292-302; discussion 303. 2007
    The carcinoma in situ (CIS) stage is the common precursor of testicular germ cell tumours (TGCTs) that arise in young adults...
  51. ncbi Control group and maintenance treatment with bacillus Calmette-Guerin for carcinoma in situ and/or high grade bladder tumors
    J Palou
    Department of Urology, , , Barcelona, Spain
    J Urol 165:1488-91. 2001
    ..instillations of bacillus Calmette-Guerin have demonstrated satisfactory results in the treatment of vesical carcinoma in situ and high grade superficial bladder tumors...
  52. ncbi Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    Testicular germ-cell tumours of young adults are derived from a pre-invasive intratubular lesion, carcinoma in situ (CIS)...
  53. doi Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections
    Hiroko Ida-Yonemochi
    Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mod Pathol 25:784-94. 2012
    Immunohistochemical loss of keratin (K)13 is one of the most valuable diagnostic criteria for discriminating carcinoma in situ (CIS) from non-malignancies in the oral mucosa while K13 is stably immunolocalized in the prickle cells of ..
  54. doi Screening breast MR imaging in women with a history of lobular carcinoma in situ
    Janice S Sung
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 10065, USA
    Radiology 261:414-20. 2011
    To assess the utility of screening magnetic resonance (MR) imaging in the detection of otherwise occult breast cancers in women with a history of lobular carcinoma in situ (LCIS).
  55. doi Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with bacillus Calmette-Guérin
    Joan Palou
    Department of Urology, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur Urol 62:118-25. 2012
    ..Controversy exists over the most important prognostic factors in T1 high-grade non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG)...
  56. pmc Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women
    Nancy A Hessol
    Department of Clinical Pharmacy, University of California, San Francisco, California 94122, USA
    AIDS 23:59-70. 2009
    ..To study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (HPV), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for HIV infection...
  57. pmc Performance of papanicolaou testing and detection of cervical carcinoma in situ in participants of organized cervical cancer screening in South Korea
    Mi Ah Han
    Department of Preventive Medicine, College of Medicine, Chosun University, Gwangju, Korea
    PLoS ONE 7:e35469. 2012
    The present study measured the performance of the Papanicolaou (Pap) test and detection of cervical carcinoma in situ (CIS) and cancer in participants of organized cervical cancer screening in South Korea, and examined differences in the ..
  58. ncbi Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors
    Karsten Zieger
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University, Denmark
    Clin Cancer Res 11:7709-19. 2005
    ..3 (FGFR3) gene as marker for the "papillary" pathway with good prognosis, in contrast to the more malignant "carcinoma in situ" (CIS) pathway...
  59. doi Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..To study telomere dysfunction in the surrounding background epithelium of squamous cell carcinoma in situ (CIS) of the oesophagus, we measured telomere lengths of basal and parabasal cells of epithelia with and ..
  60. doi ICUD-EAU International Consultation on Bladder Cancer 2012: Non-muscle-invasive urothelial carcinoma of the bladder
    Maximilian Burger
    Department of Urology and Pediatric Urology, Julius Maximilians University Medical Center, Wurzburg, Germany
    Eur Urol 63:36-44. 2013
    ....
  61. doi Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies
    Anna K Wong
    Department of Pathology and Laboratory Medicine, George Burns and Gracie Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 23:144-50. 2010
    ..In addition, a subset of these that were associated with type 16 or 18 showed progression, whereas those associated with non-16/18 subtypes regressed, thereby raising the possibility of conservative management for these lesions...
  62. pmc Changing patterns of anal canal carcinoma in the United States
    Rebecca A Nelson
    City of Hope, Department of Surgery, Division of Surgical Oncology, 1500 E Duarte Rd, Duarte, CA 91010, USA
    J Clin Oncol 31:1569-75. 2013
    ..Persistent human papillomavirus infection is associated with squamous cell carcinoma of the anal canal (SCCA). With changing sexual behaviors, SCCA incidence and patient demographics may also have changed in recent years...
  63. pmc Overdiagnosis in organised mammography screening in Denmark. A comparative study
    Karsten J Jørgensen
    The Nordic Cochrane Centre, Rigshospitalet, Dept 3343, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMC Womens Health 9:36. 2009
    ..We quantified overdiagnosis in the Danish mammography screening programme, which is uniquely suited for this purpose, as only 20% of the Danish population has been offered organised mammography screening over a long time-period...
  64. pmc Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
    Christopher Jedeszko
    Department of Pharmacology, Wayne State University, Detroit, Michigan, USA
    Cancer Res 69:9148-55. 2009
    ..The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive breast carcinoma is marked by infiltration of stromal fibroblasts and the loss of ..
  65. pmc Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage
    CATHERINE CARRIERE
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 6:e27725. 2011
    ..Thus, these data show that oncogenic Kras-driven PanIN originating in a non-ductal compartment can rapidly progress to PDAC when subjected to a brief inflammatory insult...
  66. ncbi Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Cancer 100:2562-72. 2004
    Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts...
  67. ncbi Malignant progression of anal intra-epithelial neoplasia
    Angus J M Watson
    Department of Surgery, Colorectal Unit, Christchurch Hospital, New Zealand
    ANZ J Surg 76:715-7. 2006
    ..This study reviews our experience with AIN, reviewing the incidence and risk factors for development of invasive malignancy and the outcome of present management strategies...
  68. ncbi Predictors of invasive breast cancer in patients with an initial diagnosis of ductal carcinoma in situ: a guide to selective use of sentinel lymph node biopsy in management of ductal carcinoma in situ
    Tina W F Yen
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 200:516-26. 2005
    The role of sentinel lymph node biopsy (SLNB) in patients with an initial diagnosis of ductal carcinoma in situ (DCIS) has not been well defined...
  69. doi Paclitaxel-hyaluronic acid for intravesical therapy of bacillus Calmette-Guérin refractory carcinoma in situ of the bladder: results of a phase I study
    P F Bassi
    Department of Urology, Catholic University School of Medicine, Rome, Italy
    J Urol 185:445-9. 2011
    b>Carcinoma in situ represents high grade anaplasia of the bladder mucosa. Intravesical immunotherapy with bacillus Calmette-Guérin is the gold standard treatment for patients with carcinoma in situ...
  70. ncbi Pancreatic fibrosis associated with age and ductal papillary hyperplasia
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 447:800-5. 2005
    ..The presence of myofibroblasts in association with the fibrotic foci indicates an ongoing fibrogenic process...
  71. doi Treatment options for carcinoma in situ testis
    M S Mortensen
    Department of Oncology 5073, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Int J Androl 34:e32-6. 2011
    b>Carcinoma in situ testis (CIS) is known as the precursor of germ cell cancer of the testis. International guidelines on diagnosis and treatment are inconsistent...
  72. ncbi Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
    ..In our recent gene expression study we detected AP-2gamma in carcinoma in situ testis (CIS, or intratubular germ cell neoplasia), precursor of testicular germ cell tumors...
  73. doi Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1α in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study
    Zhen Wang
    The Ultrasonagraphy Center of Second Affiliated Hospital of Soochow University, Sanxiang Road, Suzhou 215004, PR China
    Pathol Res Pract 207:505-13. 2011
    ..We investigated tissue samples, including 117 cases of invasive ductal carcinoma (IDCa), 14 cases of ductal carcinoma in situ (DCIS), and 15 cases of intraductal hyperplasia (IDH) from breast tissues...
  74. doi Ductal carcinoma in situ: state of the science and roadmap to advance the field
    Henry M Kuerer
    The University of Texas M D Anderson Cancer Center, DCIS Discovery Program and Department of Surgical Oncology, 1515 Holcombe Blvd, Unit 444, Houston, TX 77030, USA
    J Clin Oncol 27:279-88. 2009
    Ductal carcinoma in situ (DCIS) is the fourth leading cancer for women in the United States. Understanding of the biology and clinical behavior of DCIS is imperfect...
  75. ncbi Parity, age at first birth and the risk of carcinoma in situ of the breast
    M Lambe
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 77:330-2. 1998
    ..The reproductive history of 1,368 women aged 65 or younger with a diagnosis of carcinoma in situ of the breast were compared with that of 6,837 age-matched controls drawn randomly from a population-based ..
  76. doi FOXL2 and SOX9 as parameters of female and male gonadal differentiation in patients with various forms of disorders of sex development (DSD)
    R Hersmus
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Pathol 215:31-8. 2008
    ..All seminiferous tubules containing carcinoma in situ (CIS), the malignant counterpart of a primordial germ cell, ie the precursor of type II germ cell tumours of ..
  77. ncbi Ductal carcinoma in situ of the breast results of conservative and radical treatments in 716 patients
    B Cutuli
    Department of Radiotherapy, Centre Paul Strauss, Strasbourg, France
    Eur J Cancer 37:2365-72. 2001
    Until now, less than 5% of the patients with breast ductal carcinoma in situ (DCIS) have been enrolled in clinical trials...
  78. ncbi Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder
    Shahrokh F Shariat
    Scott Department of Urology, Baylor College of Medicine and Methodist Hospital, Houston, Texas, USA
    J Urol 169:938-42. 2003
    We describe cyclooxygenase-2 (COX-2) expression patterns in patients with carcinoma in situ and/or stage T1 transitional cell carcinoma. We determined whether expression is associated with clinical outcome in these patients.
  79. ncbi Laryngoscopic detection of pharyngeal carcinoma in situ with narrowband imaging
    Akihito Watanabe
    Department of Otolaryngology, Keiyukai Sapporo Hospital, Sapporo, Japan
    Laryngoscope 116:650-4. 2006
    ..The purposes of this study were to verify the effectiveness of the NBI system in conducting endoscopic screening at the oropharynx and the hypopharynx...
  80. doi Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ
    Toshihiko Mikami
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Oncol 47:497-503. 2011
    ..From those specimens, 173 foci of epithelial dysplasia, 152 foci of carcinoma in situ (CIS), and 82 foci of squamous cell carcinoma (SCC) were selected according to our diagnostic criteria, ..
  81. ncbi Minimal uterine serous carcinoma: current concepts in diagnosis and prognosis
    Joseph T Rabban
    University of California San Francisco, Department of Anatomic Pathology, San Francisco, CA 94143, USA
    Pathology 39:125-33. 2007
    ..We review the diagnostic criteria for minimal USC, pitfalls in the differential diagnosis, and discuss a practical approach to evaluating biopsies, polypectomies, or hysterectomies containing minimal USC...
  82. doi Ductal carcinoma in situ of the breast in younger women: a subgroup of patients at high risk
    C Tunon-de-Lara
    Department of Surgery, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Eur J Surg Oncol 36:1165-71. 2010
    ..breast conservative treatment (BCT), young age is a predictive factor for recurrence in patients with Ductal Carcinoma In Situ (DCIS) of the breast...
  83. ncbi Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer
    Wendie A Berg
    American College of Radiology Imaging Network, 301 Merrie Hunt Drive, Lutherville, MD 21093, USA
    Radiology 233:830-49. 2004
    ..To prospectively assess accuracy of mammography, clinical examination, ultrasonography (US), and magnetic resonance (MR) imaging in preoperative assessment of local extent of breast cancer...
  84. doi Molecular grading of ductal carcinoma in situ of the breast
    Rosemary L Balleine
    Translational Oncology Sydney West Area Health Service, Australia
    Clin Cancer Res 14:8244-52. 2008
    Increased incidence of ductal carcinoma in situ (DCIS) associated with mammographic screening for breast cancer has emphasized the challenges of managing this condition...
  85. ncbi Long-term outcome of a low-dose intravesical bacillus Calmette-Guerin therapy for carcinoma in situ of the bladder: results after six successive instillations of 40 mg BCG
    Soichi Mugiya
    Department of Urology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Jpn J Clin Oncol 35:395-9. 2005
    ..We employed a dose of 40 mg once a week for six consecutive weeks in principle for carcinoma in situ (CIS) of the bladder, and retrospectively evaluated its effectiveness and safety.
  86. doi Magnetic resonance imaging of ductal carcinoma in situ: what is its clinical application? A review
    Arjan P Schouten van der Velden
    Department of Surgical Oncology, Radboud University Nijmegen, The Medical Center, Nijmegen, The Netherlands
    Am J Surg 198:262-9. 2009
    After breast-conserving surgery of ductal carcinoma in situ (DCIS) of the breast or invasive breast carcinoma with an extensive intraductal component, tumor-positive surgical margins are frequently found...
  87. ncbi KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ
    Anja Dankof
    Institute of Pathology, Campus Charite Mitte, Charite, Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Virchows Arch 451:877-81. 2007
    ..to evaluate protein expression of Karyopherin alpha 2 (KPNA2) in invasive breast cancer and matched ductal carcinoma in situ (DCIS) and to correlate it with clinicopathological data, including patient survival...
  88. ncbi Familial and sporadic pancreatic carcinoma, epidemiologic concordance
    Arnold M Schwartz
    Am J Surg Pathol 31:645-6. 2007
  89. doi Intraepidermal and dermal Merkel cell carcinoma with squamous cell carcinoma in situ: a case report with review of literature
    Sasis Sirikanjanapong
    Department of Surgical Pathology, Tisch Hospital, New York University, School of Medicine, New York, NY 10016, USA
    J Cutan Pathol 37:881-5. 2010
    ..We report a case of MCC with an intraepidermal component admixed with squamous cell carcinoma in situ (SCCIS)...
  90. pmc Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    Pawel K Mazur
    Second Department of Internal Medicine and Institute of Pathology, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 107:13438-43. 2010
    ..Our study supports the concept of distinctive roles of individual Notch receptors in cancer development...
  91. ncbi The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow
    G Borzacchiello
    Department of Pathology Animal Health, University of Naples, Italy
    Vet Pathol 38:113-6. 2001
    A case of urothelial carcinoma in situ of urinary bladder is reported in a 10-year-old cow naturally grazing on bracken-infested land. The cow suffered from enzootic hematuria for more than 5 years...
  92. doi Salivary duct carcinoma in situ of the parotid gland
    R H W Simpson
    Department of Histopathology, Royal Devon and Exeter Hospital, Exeter, UK
    Histopathology 53:416-25. 2008
    ..To describe three cases of purely in situ salivary duct carcinoma, so as better to define the entity...
  93. doi Post-operative radiotherapy for ductal carcinoma in situ of the breast--a systematic review of the randomised trials
    Annabel Goodwin
    Familial Cancer Service, Westmead Hospital, Westmead 2145, Australia
    Breast 18:143-9. 2009
    ..of randomised trials testing the addition of radiotherapy (RT) to breast conserving surgery for ductal carcinoma in situ (DCIS); to determine whether there are subsets of women with DCIS who do not benefit from RT; and to ..
  94. pmc Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ
    Vera Novitskaya
    School of Cancer Sciences and Department of Pathology, The University of Birmingham, Birmingham, United Kingdom
    Cancer Res 70:4698-708. 2010
    ..and morphogenetic activities of CD151, we analyzed the expression of this tetraspanin in ductal carcinoma in situ (DCIS), which is characterized by neoplastic proliferation of mammary epithelial cells...
  95. ncbi Familial risks in cervical cancer: is there a hereditary component?
    K Hemminki
    Department of Biosciences, Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 82:775-81. 1999
    ....
  96. ncbi Computerized image analysis of Ki-67 in ductal breast carcinoma in situ
    D G Menter
    Departments of Clinical Cancer Prevention and Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    Anal Quant Cytol Histol 23:218-28. 2001
    ..tests were performed on lymph node tissues and cultured human breast cells and then applied to 200 ductal carcinoma in situ (DCIS) samples...
  97. doi Microarray analysis of normal cervix, carcinoma in situ, and invasive cervical cancer: identification of candidate genes in pathogenesis of invasion in cervical cancer
    J Y Song
    Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
    Int J Gynecol Cancer 18:1051-9. 2008
    The objective of this study was to identify genes that are related to pathogenesis of carcinoma in situ (CIS) to invasive cervical cancer with the use of oligonucleotide microarray and reverse transcription-polymerase chain reaction (RT-..
  98. pmc Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:39-47. 2011
    Through this study, the authors sought to investigate the biologic and immunologic effects of preoperative trastuzumab in patients with ductal carcinoma in situ (DCIS) of the breast.
  99. doi Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ
    C Desmetz
    Department of Cellular Biology, CHU Montpellier, Hopital Arnaud de Villeneuve, Montpellier, France
    J Proteome Res 7:3830-7. 2008
    ..directed against this protein in the sera of 240 individuals, comprising patients with either ductal carcinoma in situ (DCIS) ( n = 49) or early stage breast cancer ( n = 58), other cancers ( n = 20), autoimmune disease ( n = ..
  100. doi Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin
    Kirsten D Mertz
    Kempf and Pfaltz Histological Diagnostics, Research Unit, Zurich, Switzerland
    Hum Pathol 41:1369-79. 2010
    ..In one of our patients with Merkel cell polyomavirus-positive carcinoma in situ, 9 (39...
  101. ncbi Smoking and oral contraceptives as risk factors for cervical carcinoma in situ
    N Ylitalo
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 81:357-65. 1999
    ..OC) use were collected through telephone interviews with 422 case patients diagnosed with cervical carcinoma in situ and 422 control subjects...

Research Grants78

  1. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..that preneoplastic IDPs progressively develop into more advanced neoplastic lesions called "ductal carcinoma in situ" or DCIS...
  2. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..A 3D culture model of ductal carcinoma in situ will be used to test if altering mechanical or biochemical BM signaling leads to decreased DSB repair in ..
  3. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..models each induce a separate precursor state to advanced bladder cancer: either papillary tumors or carcinoma in situ, as seen in early stages of clinical bladder cancer...
  4. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..specimen collection includes 80 triple negative, 51 HER2 positive, 26 ER positive, 11 normal and 20 ductal carcinoma in situ (DCIS) samples...
  5. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..environmentally relevant doses of BPA in rodents resulted in induction of preneoplastic ductal hyperplasias, carcinoma in situ, and increased susceptibility to tumorigenesis...
  6. Ecd as a regulator of cell cycle and breast oncogenesis
    Vimla Band; Fiscal Year: 2013
    ..Notably, Ecd is overexpressed in breast cancer cell lines as well as in ductal carcinoma in situ and infiltrating ductal carcinomas of the breast...
  7. Breast Carcinoma in situ: Predicting Risk and Outcomes
    Amy Trentham-Dietz; Fiscal Year: 2013
    ..of widespread screening mammography, approximately 20% of breast cancer diagnosed today is breast carcinoma in situ (BCIS)...
  8. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..of d- limonene and its associated biological activities in women with a recent diagnosis of ductal carcinoma in situ, lobular carcinoma in situ, or atypical ductal hyperplasia elected to undergo excision surgery...
  9. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    ..This will be accomplished by using sera from women with ductal carcinoma in situ (DCIS) of the breast for cloning the new antigens, and by selecting cloning sera containing antibodies not ..
  10. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    George Timothy Bowden; Fiscal Year: 2013
    ..e. actinic keratosis, squamous cell carcinoma in situ) and dramatically reduce the risk of squamous cell carcinoma of the skin...
  11. Measuring signaling pathway dynamics during tissue growth in hydrogels
    Lonnie D Shea; Fiscal Year: 2013
    ..invasive breast cancer, and in 50% estrogen receptor (ER) negative and 12% of ER positive cases of ductal carcinoma in situ. The proposed studies focus on TFs that drive the transition from a normal to a pre-invasive phenotype (Aim ..
  12. A her-2/neu Pulsed DC1 Vaccine for Patients with DCIS
    BRIAN JOSEPH CZERNIECKI; Fiscal Year: 2012
    ..I and class II peptides derived from HER-2/neu administered in a neoadjuvant trial to patients with ductal carcinoma in situ (DCIS) resulted in near uniform sensitization of HER-2/neu specific CD4, and CD8 T cells, induction of ..
  13. Disparities in cervical cancer precursors and deregulation of imprinted genes
    Susan Kay Murphy; Fiscal Year: 2013
    ..incidence and mortality, an estimated 11,000 cases of invasive cervical cancer (ICC) and 40,000 cases of carcinoma in situ (CIS) continue to be diagnosed every year in the United States...
  14. Smoothened function as a G-Protein Coupled Receptor in mammary epithelial cells
    Hugo Villanueva; Fiscal Year: 2013
    ..Smoothened (SMO), a critical component of the Hh pathway, is overexpressed in about 70% of ductal carcinoma in situ (DCIS), and about 30% of invasive breast cancer...
  15. Radiation and Genomic Instability in Finite Lifespan Human Mammary Epithelium
    Amy Kronenberg; Fiscal Year: 2010
    ..genomic instability first appears in human breast biopsy materials at the earliest malignant stage - ductal carcinoma in situ - suggesting that instability is an important early feature in the development of breast cancer...
  16. miRNA Biomarkers from FFPE Tissue for Early Breast Cancer Detection
    Sidney W Fu; Fiscal Year: 2013
    ..They are ductal epithelial hyperplasia (DEH), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS)...
  17. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..Breast Cancer Survivors;(5) Brian Sprague, PhD, Behaviors, Chronic Disease, and Quality of Life After Ductal Carcinoma In Situ. The proposed center will bring together an interdisciplinary group of accomplished senior scientists, ..
  18. Innate Immunity and Oral Carcinogenesis
    Ge Jin; Fiscal Year: 2011
    ..We have found that tumor cells in oral carcinoma in situ (CIS) overexpress human β-defensin-3 (hBD-3), an antimicrobial peptide of the innate immune system...
  19. Epigenetic Control of HPV-associated Oral Carcinogenesis
    Cun Yu Wang; Fiscal Year: 2013
    ..that AP-1 plays a critical role in the invasive growth of OSCC which is required for the progression of carcinoma in situ to OSCC...
  20. Role of CCN6 (WISP3) in the progression and metastasis of breast cancer
    Celina G Kleer; Fiscal Year: 2012
    ..IGF-1 signaling in vivo using unique human tissue resources consisting of samples of normal breast, ductal carcinoma in situ (DCIS), invasive carcinomas, and nodal and distant metastases...
  21. Environmental Epigenetics and Stem/Progenitor Cell Injury
    Tim H M Huang; Fiscal Year: 2010
    ..the history of xenoestrogen- induced breast tumorigenesis, from pre-neoplastic lesions to hyperplasia to carcinoma in situ to invasive carcinoma...
  22. Translational control during fetal male germ cell development
    CHRIS BENNETT GEYER; Fiscal Year: 2012
    ..to the recent increase in testicular dysgenesis syndrome, a spectrum of male reproductive disorders such as carcinoma in situ, testicular cancer, cryptorchidism, and hypospadia that originate during this fetal period of germ cell ..
  23. Manipulating b1 integrin to enhance radiation therapy for breast cancer
    Catherine C Park; Fiscal Year: 2012
    ..mediates a survival signal via Akt using 3D IrECM culture models of invasive breast cancer and ductal carcinoma in situ (DCIS) and to expand upon the Akt-mediated survival effects of Beta1 integrin signaling post-IR in the ..
  24. MRI of Early Non-invasive Rodent Mammary Cancers
    Gregory S Karczmar; Fiscal Year: 2013
    ..We will study mouse mammary intra-epithelial neoplasia (MIN);this early, non-invasive neoplasia is very similar to ductal carcinoma in situ, or DCIS, in humans.
  25. Multicenter Genetic, Epigenetic &Expression Analysis of DCIS outcome predictors
    Christopher B Umbricht; Fiscal Year: 2013
    ..The goal of this project is to identify the molecular alterations that occur in the progression from ductal carcinoma in situ (DCIS) to invasive breast cancer...
  26. A tool for analysis of gene-specific DNA methylation in clinical samples
    Victor V Levenson; Fiscal Year: 2010
    ..To confirm the utility of the tool, biomarkers for detection of invasive breast cancer and ductal carcinoma in situ will be developed...
  27. Syndecan-1 in Stromal Fibroblasts of Breast Carcinomas
    Andreas Friedl; Fiscal Year: 2013
    ..Aim 2: Analyze the role of Sdc1 and ECM architecture in the progression from ductal carcinoma in situ (DCIS) to invasive carcinoma...
  28. Stem cells and their aberrant self-renewal pathways in DCIS malignant progression
    Kelli E Valdez; Fiscal Year: 2013
    ..Ductal carcinoma in situ (DCIS) is a non-invasive cancer lesion that progresses to invasive cancer approximately half the time...
  29. Role of EZH2 in Breast Cancer Progression
    Celina G Kleer; Fiscal Year: 2013
    ..cycle, we have demonstrated that EZH2 protein is upregulated during progression from normal breast to ductal carcinoma in situ, the precursor of invasive carcinoma, to invasive carcinoma, being highest at the metastasis...
  30. Digital Pathology_Accuracy Viewing Behavior and Image Characterization
    DONALD LEE WEAVER; Fiscal Year: 2013
    ..likely lead to altered patient treatment, especially at the thresholds of atypical hyperplasia and ductal carcinoma in situ, where up to 50% of cases are misclassified. The causes underlying these errors remain largely unknown...
  31. C/EBPb Modulates Macrophages and Tumor-Initiating Cells During Preneoplastic Prog
    Heather L Machado; Fiscal Year: 2013
    ..Gene profiling studies of both pre-malignant DCIS (ductal carcinoma in situ) and invasive breast cancer have resulted in the classification of various subtypes, which largely dictate ..
  32. C/EBPb Modulates Macrophages and Tumor-Initiating Cells During Preneoplastic Prog
    Heather L Machado; Fiscal Year: 2012
    ..Gene profiling studies of both pre-malignant DCIS (ductal carcinoma in situ) and invasive breast cancer have resulted in the classification of various subtypes, which largely dictate ..
  33. Using Markers to Improve Pancreatic Cancer Screening
    Michael G Goggins; Fiscal Year: 2013
    ..ultrasound are detected in patients with pancreatic cancer and patients undergoing pancreatic screening with carcinoma in situ or invasive cancer, not in disease controls or those with low-grade dysplasia...
  34. Progression of DCIS to invasive breast cancer through CCR2 chemokine signaling
    Nikki Cheng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ductal carcinoma in situ (DCIS) is the most common type of non-invasive breast cancer diagnosed in women and an immediate precursor to invasive ductal carcinoma (IDC)...
  35. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..Our goal is to minimize risks of localized treatment of carcinoma in situ associated with PDT, laser, APC therapies, etc. but offer similar benefit...
  36. miR-140 and Breast Cancer Prevention
    Qun Zhou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with ductal carcinoma in situ (DCIS) have significant risks of developing recurrence or invasive breast cancer even after they receive breast surgery...
  37. Costs and Complications of Radiotherapy Modalities
    Heather Taffet Gold; Fiscal Year: 2012
    ..costs and complications of two radiotherapy (RT) techniques used for early invasive breast cancer and ductal carcinoma in situ (DCIS)...
  38. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie F Sloane; Fiscal Year: 2013
    Mammographic screening leads to many women being diagnosed with ductal carcinoma in situ [DCIS], yet we cannot accurately predict which lesions will undergo malignant progression to invasive ductal carcinomas [IDC] or effectively block ..
  39. CpG Island Methylator Phenotypes in Breast Cancer
    Tim H M Huang; Fiscal Year: 2011
    ..that simulates the history of methylation alteration from pre-neoplastic lesions to hyperplasia to ductal carcinoma in situ to invasive cancers...
  40. Multiscale Modeling of ECM-tumor interactions in Breast Cancer
    Alissa M Weaver; Fiscal Year: 2013
    ..Conversely, basement membrane ECM proteins that underlie normal and carcinoma in situ epithelial cells are thought to inhibit tumor progression...
  41. Effectiveness of Pre-Operative MRI in Breast Cancer Surgery and Outcomes
    Tracy Onega; Fiscal Year: 2013
    ..primarily from community settings, enabling us to examine subgroups of women, such as those with ductal carcinoma in situ, dense breasts or family history of breast cancer, and to have greater generalizability than previous ..
  42. Quantitative Mechanical Imaging for Improving Breast Ultrasound Diagnosis
    Timothy J Hall; Fiscal Year: 2013
    ..Third, measurements of ex vivo breast tissue samples found that ductal carcinoma in situ (DCIS) has the highest elastic nonlinearity of all tissues considered...
  43. Accuracy of Breast Pathology and the Impact of Double Reading
    DONALD LEE WEAVER; Fiscal Year: 2013
    ..ADH) in more than 50% of cases and a misclassification rate for cases designated by experts as ductal carcinoma in situ (DCIS) of 17%...
  44. Role of IGF-I Receptor Signaling Pathways in Cell Survival and Migration
    Hanna Y Irie; Fiscal Year: 2010
    ..Hanna Irie is a researcher and a medical oncologist specializing in breast cancer who is committed to becoming an independent laboratory-based scientist dedicated to understanding the role of growth factors in breast tumorigenesis. ..
  45. Beta-Catenin/TCF Signaling in Breast Cancer
    Louise R Howe; Fiscal Year: 2012
    ..studies have revealed evidence of beta-catenin/TCF pathway activation in breast hyperplasias and ductal carcinoma in situ (DCIS) lesions, frequent precursors to invasive breast cancer...
  46. A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment
    JONATHAN QUINCY BROWN; Fiscal Year: 2012
    ..provided by applicant): In 2009, an estimated 197,300 women with early stage invasive breast cancer and/or carcinoma in situ (CIS) received breast conserving surgery (BCS)...
  47. Chemokine Receptor Modulation of the Tumor Microenvironment
    Oriana E Hawkins; Fiscal Year: 2012
    ..the tumor microenvironment (TME) that interact with the inflammatory cells to mediate progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)...
  48. RNA from Brush Cytology to Detect Squamous Cell Carcinoma
    Joel L Schwartz; Fiscal Year: 2011
    ..based class predictor for the earliest stage of squamous cell carcinoma, moderate to severe dysplasia and carcinoma in situ. After analysis of RNA from brush cytology from pre-cancerous oral lesions, we will use statistical ..
  49. Multi-marker prognostic profile to predict invasive progression in DCIS patients
    Steven P Linke; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. The lesions are typically surgically removed...
  50. Risk Factors for Second Primary Breast Cancer Among DCIS Survivors
    Christopher I Li; Fiscal Year: 2013
    ..this work by evaluating factors that are related to risk of second primary breast cancers among ductal carcinoma in situ (DCIS) survivors. Incidence rates of DCIS have increased 7...
  51. SPORE IN BREAST CANCER
    SARA SUKUMAR; Fiscal Year: 2010
    ..Research Project 1 focuses on identification of molecular markers for progression of ductal carcinoma in situ, building on a successful research program for detecting epigenetic molecular markers...
  52. Characterizing the Evolution of Pre-malignant Tissues at High Risk for Malignancy
    THEA D contact TLSTY; Fiscal Year: 2010
    ..These markers identify a highly aggressive pre-malignant subtype that we call "basal-like" ductal carcinoma in situ (B-L DCIS) in this application since it shares markers specific to basal-like invasive tumors...
  53. Novel Tree-based Statistical Methods for Cancer Risk Prediction
    Annette M Molinaro; Fiscal Year: 2013
    ..A definitive example is mammography and ductal carcinoma in situ (DCIS), a noninvasive breast cancer...
  54. Myoepithelial cell differentiation defects in ductal carcinoma in situ (DCIS)
    Kornelia Polyak; Fiscal Year: 2013
    ..abstract_text> ..
  55. Analytical Investigation of Breast Cancer Progression: DCIS, Overdiagnosis
    Sandra J Lee; Fiscal Year: 2013
    ..principal research areas include:(i) Develop a stochastic model for the disease progression of breast ductal carcinoma in situ (DCIS), (ii) Investigate the natural history of breast cancer, including methods for estimating the pre-..
  56. Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
    PATRICIA ANN MASSO-WELCH; Fiscal Year: 2013
    ..little research conducted to determine if pure invasive ductal carcinoma (IDC) with no concomitant ductal carcinoma in situ (DCIS) differs from mixed IDC with DCIS in etiology, prognosis, or microenvironment, although there are some ..
  57. MRI For Staging DCIS and Assessing Response to Treatment
    Nola M Hylton; Fiscal Year: 2010
    Ductal carcinoma in situ (DCIS) is an early, pre-invasive form of breast cancer that conveys an excellent prognosis if local control is achieved...
  58. Development of a Hyper-spectral Spectroscopic Instrument for Non-invasive Diagnos
    James W Tunnell; Fiscal Year: 2012
    ..Of particular importance is the depth of a malignancy which is often used to stage disease (e.g. carcinoma in situ vs. invasive carcinoma)...
  59. Vermont PROSPR Research Center (VPRC)
    Brian L Sprague; Fiscal Year: 2013
    ..by developing prognostic markers that can be used to develop personalized management strategies for ductal carcinoma in situ (DCIS)...
  60. DNA methylation markers for cervical intraepithelial neoplasia III
    Qinghua Feng; Fiscal Year: 2009
    ..to identify novel DNA methylation markers for detection of cervical intraepithelial neoplasia 3 (CIN-3) and carcinoma in situ (CIS), to access their clinical utility in identifying underlying CIN-3/CIS lesions among women with ..
  61. Green tea catechins in precancerorus prevention
    HWA CHAIN WANG; Fiscal Year: 2009
    ....
  62. Hospital and County-Level Predictors of Immediate Breast Reconstruction Post-Mast
    CATHERINE ANN RICHARDS; Fiscal Year: 2012
    ..Inpatient Sample (NIS) on ~42,000 women who underwent mastectomy to treat invasive breast cancer or ductal carcinoma in situ (DCIS) will be combined with hospital-level data from the NIS, the American Hospital Association (AHA) and ..
  63. Stromal activation in the progression of high ErbB2/1433zeta DCIS to IBC
    Dihua Yu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Studying the transition from non-invasive ductal carcinoma in situ (DCIS) to life-threatening invasive breast cancer (IBC) is listed in the top quartile of the 100 research priorities by the ..
  64. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..The Carolina Breast Cancer Study (CBCS) and the Carcinoma In Situ (CIS) Study are population-based, case-control studies of invasive breast cancer and carcinoma in situ in ..
  65. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    ..The results of this studio could fundamentally change the management of bladder cancer. [unreadable] [unreadable]..
  66. Urinary matrix metalloproteinases and breast cancer risk in a prospective cohort
    Lesley M Butler; Fiscal Year: 2013
    ..in early breast tumorigenesis, and in the angiogenic switch that may result a subgroup of dysplasia/carcinoma in situ that is prone to progression toward invasive disease...
  67. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    ..g., carcinoma in situ) in vivo, noninvasivelv, instantaneously and at high resolution...
  68. CHEMOPREVENTION IN HUMAN BRONCHIAL METAPLASIA/DYSPLASIA
    WAUN HONG; Fiscal Year: 1991
    ..This study will provide the information necessary to develop a rational approach for premalignant squamous metaplasia/dysplasia and to direct the future development of chemoprevention in lung cancer...
  69. A Video DVD Program to Assist with Informed Consent
    Neil Love; Fiscal Year: 2004
    ..The NSABP B-35 trial will randomize approximately 3,000 women with Ductal Carcinoma In Situ (DCIS) to either the nonsteroidal aromatase inhibitor, anastrozole or tamoxifen...
  70. Impact of ErbB2 and RB Pathways on DCIS Progression and Treatment
    Agnieszka Witkiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Currently ductal carcinoma in situ (DCIS) accounts for 20-30% of newly diagnosed breast cancers in screened populations...
  71. PEROXISOME PROLIFERATOR INDUCED HEPATOCARCINOGENESIS
    Sambasiva Rao; Fiscal Year: 2004
    ..2 million new cases of cancer (excluding nonmelanoma skin cancers and carcinoma in situ of cervix), and 564000 deaths from cancer in 1998 in the United States...
  72. PNI and Decision Making in Women Diagnosed with DCIS
    LINDA JANUSEK; Fiscal Year: 2007
    ..The past decade has witnessed an increase in the number of women diagnosed with ductal carcinoma in situ (DCIS) due to the widespread use of screening mammography...
  73. Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma
    Norma Nowak; Fiscal Year: 2009
    ..a series of genetic 'hits'are required to allow cells to progress through hyperplasia, dysplasia, carcinoma in situ, invasive tumor, and metastatic tumor...
  74. ANTIBODIES TO NUCLEAR PROTEINS IN CERVICAL CANCER
    EDWARD FEY; Fiscal Year: 1992
    ..Pap smear samples and purified nuclear matrix proteins from normal patients and from patients with carcinoma in situ. Nuclear matrix proteins are low abundance nonhistone proteins that are involved in nuclear structure and ..
  75. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
  76. IMMUNE RESPONSE TO BREAST DUCTAL CARCINOMA IN SITU
    Scott Pruitt; Fiscal Year: 1999
    ..If indicated by these initial studies, therapy directed against both the complement and NAb components of the response will be combined in an effort to further prolong xenograft survival. ..
  77. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..The specific aims of the clinical studies are to determine the efficacy of PDT in Carcinoma In Situ (CIN) in the female genital tract employing topical (non-systemic) drug application...
  78. Immune dysregulation by psychosocial distress
    HERBERT MATHEWS; Fiscal Year: 2006
    ..In the past decade, the number of women diagnosed with the form of breast cancer known as ductal carcinoma in situ (DCIS) has markedly increased...