Genomes and Genes
Summary: A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (From Holland et al., Cancer Medicine, 3d ed, p1455; Stedman, 25th ed)
Publications342 found, 100 shown here
- Risk factors for cholangiocarcinomaGia L Tyson
Section of Gastroenterology at the Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Hepatology 54:173-84. 2011b>Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy after hepatocellular cancer. CC accounts for approximately 10%-25% of all hepatobiliary malignancies...
- Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significanceAndreas Karakatsanis
Aretaieion Hospital, Surgical Department, School of Medicine, University of Athens, Greece
Mol Carcinog 52:297-303. 2013..145, -146a, - 200c, -221, -222 and -223) in patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), as well as to assess their prognostic significance...
- Exome sequencing of liver fluke-associated cholangiocarcinomaChoon Kiat Ong
National Cancer Centre Singapore Van Andel Research Institute Translational Research Laboratory, Division of Medical Sciences, Singapore
Nat Genet 44:690-3. 2012Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O...
- CholangiocarcinomaShahid A Khan
Liver Unit, Division of Medicine, St Mary s Hospital Campus, Faculty of Medicine, Imperial College London, London, UK
Lancet 366:1303-14. 2005b>Cholangiocarcinoma is a devastating malignancy that presents late, is notoriously difficult to diagnose, and is associated with a high mortality. The incidence of intrahepatic cholangiocarcinoma is increasing worldwide...
- The epidemiology of cholangiocarcinomaYasser Shaib
Sections of Gastroenterology and Health Services Research, The Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Semin Liver Dis 24:115-25. 2004The incidence rates of cholangiocarcinoma (CC) vary greatly among different areas of the world, and this variation is related to distribution of risk factors...
- Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and LaosBanchob Sripa
Tropical Disease Research Laboratory, Department of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand
Acta Trop 120:S158-68. 2011..viverrini through these two regions. We also review the association of O. viverrini infection and cholangiocarcinoma, bile duct cancer, and highlight new findings on pathogenesis of liver fluke-induced cholangiocarcinogenesis...
- Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinomaTing Lei Gu
Cell Signaling Technology, Danvers, Massachusetts, United States of America
PLoS ONE 6:e15640. 2011b>Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The molecular mechanisms underlying the development of this disease are not clear...
- CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinomaLinni Fan
State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
BMC Cancer 11:320. 2011..Nevertheless, the expression of CD133 in human cholangiocarcinoma (CC) is rare and our study is to detect the expression and explore the potential functions of CD133 in human ..
- MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpointAlexandru V Olaru
Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
Hepatology 54:2089-98. 2011..pathways and mechanisms through which miR-494, one of the miR species found to be down-regulated in cholangiocarcinoma (CCA), participates in cancer homeostasis...
- E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinomaK Araki
Department of General Surgical Science Surgery 1, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, Japan
Br J Cancer 105:1885-93. 2011..This study aimed to investigate whether cadherin switch promotes cancer progression in cholangiocarcinoma (CC).
- Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinomaRegina V Tse
Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
J Clin Oncol 26:657-64. 2008To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC).
- Intratumoral IL-17⁺ cells and neutrophils show strong prognostic significance in intrahepatic cholangiocarcinomaFang Ming Gu
Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai, People s Republic of China
Ann Surg Oncol 19:2506-14. 2012..This study was designed to assess the clinical significance of tumor-infiltrating inflammatory cells in patients with intrahepatic cholangiocarcinoma (ICC).
- Mutational profiling reveals PIK3CA mutations in gallbladder carcinomaVikram Deshpande
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
BMC Cancer 11:60. 2011..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined...
- Guidelines for the diagnosis and treatment of cholangiocarcinoma: an updateShahid A Khan
Department of Hepatology and Gastroenterology Section, Imperial College London, London, UK
Gut 61:1657-69. 2012The British Society of Gastroenterology guidelines on the management of cholangiocarcinoma were originally published in 2002...
- Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus documentS A Khan
Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Hospital Campus, South Wharf Street, London W2 1PG, UK
Gut 51:VI1-9. 2002
- Liver fluke induces cholangiocarcinomaBanchob Sripa
Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
PLoS Med 4:e201. 2007
- Epidemiology of cholangiocarcinoma: an update focusing on risk factorsHai Rim Shin
International Agency for Research on Cancer, Lyon, France
Cancer Sci 101:579-85. 2010b>Cholangiocarcinoma is relatively rare, but high incidence rates have been reported in Eastern Asia, especially in Thailand. The etiology of this cancer of the bile ducts appears to be mostly due to specific infectious agents...
- Clinical diagnosis and staging of cholangiocarcinomaBoris Blechacz
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA
Nat Rev Gastroenterol Hepatol 8:512-22. 2011b>Cholangiocarcinoma is the most frequent biliary malignancy. It is difficult to diagnose owing to its anatomic location, growth patterns and lack of definite diagnostic criteria...
- The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinomaSundeep Singh
Division of Gastroenterology and Hepatology, Stanford University, 300 Pasteur Dr, Always Building, Room M211, Stanford, CA 94305, USA
Dig Dis Sci 56:2491-6. 2011CA19-9 is a tumor marker for pancreatic cancer, cholangiocarcinoma, and other malignancies. However, its sensitivity and specificity is suboptimal in clinical practice, which we hypothesized limits its clinical utility.
- Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotypingDarrell R Borger
Division of Hematology Oncology, Massachusetts General Hospital, Boston 02114 2698, USA
Oncologist 17:72-9. 2012..of mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) in tumors from a subset of patients with cholangiocarcinoma. A total of 287 tumors from gastrointestinal cancer patients (biliary tract, colorectal, gastroesophageal, ..
- Rising trends in cholangiocarcinoma: is the ICD classification system misleading us?Shahid A Khan
Liver Unit, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom
J Hepatol 56:848-54. 2012..We also examined whether coding practices by cancer registries in England and Wales could be influencing these rates...
- Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting TwistBin Li
Department of Biliary Truct Surgery I, Eastern Hepatobiliary Hospital, Secondary Military Medicine University, Shanghai, China
FEBS J 279:2393-8. 2012..However, the mechanisms by which miRNAs regulate intrahepatic cholangiocarcinoma metastasis remain poorly understood...
- Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapiesD Sia
1 HCC Translational Research Laboratory, Liver Unit, Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Catalonia, Spain 2 Gastrointestinal Surgery and Liver Transplantation Unit, National Cancer Institute, Milan, Italy
Oncogene 32:4861-70. 2013Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with very poor prognosis...
- Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control studyTania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Clin Gastroenterol Hepatol 5:1221-8. 2007..Although the incidence of extrahepatic cholangiocarcinoma (ECC) has remained constant, the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the ..
- Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cellsCy Hyun Kim
National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
Int J Nanomedicine 6:1357-63. 2011..We investigated the effect of ALA-based photodynamic therapy (PDT) on human cholangiocarcinoma cells (HuCC-T1)...
- Changing international trends in mortality rates for liver, biliary and pancreatic tumoursShahid A Khan
Liver Unit, Department of Medicine A, Faculty of Medicine, 10th Floor, QEQM Wing, Imperial College School of Medicine, St Mary s Hospital, South Wharf Street, London W2 1PG, UK
J Hepatol 37:806-13. 2002..However, in England and Wales we previously reported an increase in mortality rates from intrahepatic cholangiocarcinoma. Trends in cholangiocarcinoma in most other industrialized countries are unknown...
- Cholangiocarcinoma--controversies and challengesTushar Patel
Department of Transplantation, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Nat Rev Gastroenterol Hepatol 8:189-200. 2011..The risk factors, clinical presentation, natural history and management of these two types of cholangiocarcinoma are distinct...
- Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinomaHorlad Hasita
Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Cancer Sci 101:1913-9. 2010..phenotypes, and their correlation to angiogenesis, immunosuppression, and clinical prognosis in intrahepatic cholangiocarcinoma (ICC)...
- Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatmentBoris Blechacz
Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Hepatology 48:308-21. 2008
- Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in KoreaDongil Choi
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, IlWon Dong, Kangnam Ku, Seoul 135 710, South Korea
J Hepatol 44:1066-73. 2006The authors conducted a hospital-based case-control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of cholangiocarcinoma (CC), including extrahepatic CC, in Korea.
- Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United StatesT Patel
Division of Gastroenterology, Scott and White Clinic, Texas A and M University System Health Science Center, College of Medicine, Temple, TX 76508, USA
Hepatology 33:1353-7. 2001..Thus, our aim was to determine recent trends in the epidemiology of intrahepatic cholangiocarcinoma in the United States...
- Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissectionY Kitagawa
First Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
Ann Surg 233:385-92. 2001OBJECTIVE: To assess the status of the regional and paraaortic lymph nodes in hilar cholangiocarcinoma and to clarify the efficacy of systematic extended lymphadenectomy...
- Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell linesFanyin Meng
Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas 76508, USA
Gastroenterology 130:2113-29. 2006..Our aims were to identify specific miRNA involved in the regulation of cholangiocarcinoma growth and response to chemotherapy.
- Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disordersJochen Metzger
Mosaiques diagnostics GmbH, Hannover, Germany
Gut 62:122-30. 2013Diagnosis and curative treatment of cholangiocarcinoma (CC) often comes too late due to the lack of reliable tumour markers especially in patients with primary sclerosing cholangitis (PSC)...
- Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2Hyunho Yoon
Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
Biochem Biophys Res Commun 405:333-7. 2011Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignant tumor and is refractory to conventional chemotherapy. The aim of this study is therefore to elucidate the mechanism of chemoresistance in ICC which is not fully understood...
- Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinomaChun Nan Yeh
Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taiwan
Carcinogenesis 25:631-6. 2004b>Cholangiocarcinoma (CCA) is a lethal disease, afflicting many thousands the world over. Human CCA develops through a multi-step progression model, preceded by the onset of dysplasia in the cholangiolar ductal epithelium...
- Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencingHajime Isomoto
Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Digestion 79:2-8. 2009b>Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium, characterized by its typically late clinical presentation and lack of effective therapeutic modalities...
- Crucial role of heme oxygenase-1 on the sensitivity of cholangiocarcinoma cells to chemotherapeutic agentsSarinya Kongpetch
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
PLoS ONE 7:e34994. 2012..We aimed to investigate roles of HO-1 in human cholangiocarcinoma (CCA) cells for cytoprotection against chemotherapeutic agents...
- Viable metacercariae of Opisthorchis viverrini in northeastern Thai cyprinid fish dishes--as part of a rational program for control of O. viverrini-associated cholangiocarcinomaJiraporn Prasongwatana
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
Parasitol Res 112:1323-7. 2013..This information could be used as part of a rational and sustainable control program for O. viverrini-associated bile duct cancer...
- SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinomaAnthony B El-Khoueiry
University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Suite 3459, Los Angeles, CA 90033, USA
Invest New Drugs 30:1646-51. 2012..Based on the role of the Ras-Raf-Mek-Erk pathway and the VEGF axis in biliary carcinomas, we conducted a phase II study of sorafenib in patients with advanced biliary cancers...
- Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cellsBenjaporn Buranrat
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
World J Gastroenterol 16:2362-70. 2010..whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in cholangiocarcinoma cells (CCA) and the role of reactive oxygen generation in sensitizing the cells.
- Usefulness of slimmer and open-cell-design stents for endoscopic bilateral stenting and endoscopic revision in patients with hilar cholangiocarcinoma (with video)Jeong Yeol Kim
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Korea
Gastrointest Endosc 70:1109-15. 2009..metal stenting using a "stent-in-stent" method is currently used to treat patients with unresectable hilar cholangiocarcinoma, this method has limited application in cases of tight strictures or endoscopic revision in case of tumor ..
- Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasisTim O Lankisch
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
Hepatology 53:875-84. 2011Early detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is very difficult and often comes too late to give the patient a therapeutic benefit...
- Overexpression of CD151 as an adverse marker for intrahepatic cholangiocarcinoma patientsXiao Yong Huang
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
Cancer 116:5440-51. 2010..The objective of the current study was to investigate the expression and role of CD151 and/or c-Met in intrahepatic cholangiocarcinoma (ICC).
- Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China: a possible role of hepatitis B virusNing Fu Peng
Department of Hepatobiliary Surgery, Guangxi Medical University, Guangxi Province, China
Ann Surg Oncol 18:1258-66. 2011Recent efforts suggest an etiologic role of hepatitis B virus (HBV) infection in intrahepatic cholangiocarcinoma (ICC) and the involvement of hepatic progenitor cell in ICC development, without definitive conclusions...
- Optimum palliation of inoperable hilar cholangiocarcinoma: comparative assessment of the efficacy of plastic and self-expanding metal stentsRamu P Raju
Department of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1466, Houston, TX 77030 4009, USA
Dig Dis Sci 56:1557-64. 2011Endoscopic retrograde biliary drainage (ERBD) with plastic or self-expanding metal stents (SEMS) is often performed for palliative care for cholangiocarcinoma.
- Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocationZichen Zhang
Division of Cellular and Molecular Pathogenesis, Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
Hepatology 39:1028-37. 2004..that the cyclooxygenase-2 (COX-2) inhibitor celecoxib acts to significantly suppress the growth of rat C611B cholangiocarcinoma (ChC) cells in vitro...
- Endoscopic bilateral metal stent placement for advanced hilar cholangiocarcinoma: a pilot study of a newly designed Y stentJung Hyun Lee
Department of Internal Medicine, Pusan National University College of Medicine, Seo Gu, Busan, Korea
Gastrointest Endosc 66:364-9. 2007..endoscopic stent placement is now generally accepted as a palliative method of treatment in unresectable hilar cholangiocarcinoma, exclusively endoscopic placement of bilateral metal stents has been considered very difficult and complex.
- Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinomaTümen Mansuroglu
Department of Gastroenterology and Endocrinology, Center of Internal Medicine, University of Gottingen, Gottingen, Germany
Lab Invest 89:562-74. 2009..rat liver, in isolated normal rat liver cells and in a thioacetamide-induced rat model of intrahepatic cholangiocarcinoma (CC)...
- The E-cadherin repressor slug and progression of human extrahepatic hilar cholangiocarcinomaKe Jun Zhang
General Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qing Dao, Shandong Province, 266003, China
J Exp Clin Cancer Res 29:88. 2010This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression.
- Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cellsMakiko Taniai
Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 64:3517-24. 2004..necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for cancer therapy, including cholangiocarcinoma. However, many cholangiocarcinoma cells are resistant to TRAIL-mediated apoptosis...
- Diagnosis and treatment of cholangiocarcinomaChristopher D Anderson
Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 4753, USA
Oncologist 9:43-57. 2004b>Cholangiocarcinoma presents a formidable diagnostic and treatment challenge. The majority of patients present with unresectable disease and have a survival of less than 12 months following diagnosis...
- Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998S D Taylor-Robinson
Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Campus, South Wharf Street, London W2 1PG, UK
Gut 48:816-20. 2001..We further analysed the mortality statistics to determine which anatomical subcategories were involved...
- Liver stem cells and their implication in hepatocellular and cholangiocarcinomaT Roskams
Head Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
Oncogene 25:3818-22. 2006..Hepatocellular carcinomas expressing progenitor cell/ductular markers like cytokeratin 19 have a more aggressive clinical course. It is therefore important to recognize this entity...
- Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinomaW R Jarnagin
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Ann Surg 234:507-17; discussion 517-9. 2001To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors.
- Clonorchiasis: an updateH J Rim
Department of Paraitology, College of Medicine, Korea University, Seoul 136 705, Korea
J Helminthol 79:269-81. 2005..sometimes accompanied by suppurative cholangitis, cholecystitis, cholangiohepatitis and ultimately can cause cholangiocarcinoma. Experimental results on the relationship to the occurrence of cholangiocarcinoma are presented...
- miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinomaNataliya Razumilava
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
Hepatology 55:465-75. 2012..Although targets and functional roles for a number of microRNAs have been described in cholangiocarcinoma, many additional microRNAs dysregulated in this tumor have not been assigned functional roles...
- Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liverA Tannapfel
Institute of Pathology, University of Leipzig, Liebigstr 26, 04103 Leipzig, Germany
Gut 47:721-7. 2000..Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and K-ras mutations are among the most frequent genetic alterations in human malignancies...
- Cholangiocarcinoma: lessons from ThailandBanchob Sripa
Department of Pathology, Faculty of Medicine, Thailand
Curr Opin Gastroenterol 24:349-56. 2008To present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer.
- Systemic therapy for biliary tract cancersAram F Hezel
Tucker Gosnell Center for Gastrointestinal Cancers, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Oncologist 13:415-23. 2008..In this review, we discuss the clinical experience with systemic treatment of BTC, focusing on the rationale for a first-line regimen as well as future directions in the field...
- Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)Banchob Sripa
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
World J Gastroenterol 11:3392-7. 2005To establish and characterize a new cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand.
- Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell originMina Komuta
Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
Hepatology 47:1544-56. 2008..05), while albumin was downregulated in CLC (P = 0.007) toward K19-negative HCCs. Comparison of CLC with K19-positive HCCs indicated a high homology...
- Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinomaJunji Komori
Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
Hepatology 47:888-96. 2008..studies have demonstrated that patients with primary sclerosing cholangitis have a predisposition to develop cholangiocarcinoma (CC)...
- Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinomaLi Zhou
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100032, China
Cancer Lett 264:209-17. 2008..clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients...
- Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veteransHashem B El-Serag
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Hepatology 49:116-23. 2009..Previous case control studies indicated a possible association between HCV and intrahepatic cholangiocarcinoma (ICC)...
- Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non-Hodgkin lymphoma: a cohort study of parous women in TaiwanChyng Wen Fwu
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Hepatology 53:1217-25. 2011..This study aimed to estimate incidence rates of intrahepatic cholangiocarcinoma (ICC) and non-Hodgkin lymphoma (NHL) and its major subtypes in a nationwide cohort of parous women and to ..
- Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisionsJesse S Voss
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Hum Pathol 44:1216-22. 2013b>Cholangiocarcinoma is a highly lethal cancer of the biliary tract. The intrahepatic subtype of cholangiocarcinoma is increasing in incidence globally...
- Radiofrequency ablation for incidentally identified primary intrahepatic cholangiocarcinomaWitold Zgodzinski
Second Department of General Surgery, Skubiszewski Medicaal University of Lublin, Poland
World J Gastroenterol 11:5239-40. 2005b>Cholangiocarcinoma is the second most common primary hepato-biliary malignancy...
- Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasionApaporn Menakongka
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
World J Gastroenterol 16:713-22. 2010To investigate the role of hepatocyte growth factor (HGF) in cholangiocarcinoma (CCA) cell invasiveness and the mechanisms underlying such cellular responses.
- Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinomaC Möbius
Department of Surgery II, University of Leipzig, Leipzig, Germany
Eur J Surg Oncol 33:1025-9. 2007..In extrahepatic cholangiocarcinoma, the VEGF expression and microvessel density have rarely been investigated.
- Magnetic resonance imaging of cholangiocarcinomaRiccardo Manfredi
Department of Radiology, A Gemelli University Hospital, Rome, Italy
Semin Liver Dis 24:155-64. 2004b>Cholangiocarcinoma arises from the bile ducts and is the most common primary malignancy of the biliary tree...
- MicroRNA-26a promotes cholangiocarcinoma growth by activating β-cateninJinqiang Zhang
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
Gastroenterology 143:246-56.e8. 2012MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma.
- Establishment and characterisation of six human biliary tract cancer cell linesJ L Ku
Laboratory of Cell Biology, Korean Cell Line Bank, Cancer Research Center and Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
Br J Cancer 87:187-93. 2002..one hilar bile duct cancer), two adenocarcinomas of ampulla of Vater, one intrahepatic bile duct cancer (cholangiocarcinoma), and one adenocarcinoma of the gall bladder...
- Worldwide trends in mortality from biliary tract malignanciesTushar Patel
Division of Gastroenterology Scott and White Memorial Hospital and Clinic Texas A and M University System Health Science Center College of Medicine Temple, TX, USA
BMC Cancer 2:10. 2002..variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity...
- Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cellsHiroaki Sugiyama
Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki, Japan
J Gastroenterol 46:779-89. 2011Intrahepatic cholangiocarcinoma (ICC) is rising in clinical importance due to the increasing incidence worldwide, poor prognosis, and suboptimal response to therapies...
- Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytesSayaka Sekiya
Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Clin Invest 122:3914-8. 2012Intrahepatic cholangiocarcinoma (ICC) is the second most common primary malignancy in the liver...
- Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinomaK Sugimachi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 14:900-5. 2001..of beta-catenin to determine the role of beta-catenin in cancer formation and/or progression in intrahepatic cholangiocarcinoma (ICC)...
- Anti-tumor activity of all-trans retinoic acid-incorporated glycol chitosan nanoparticles against HuCC-T1 human cholangiocarcinoma cellsKyu Don Chung
Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University, Seoul 137 701, Republic of Korea
Int J Pharm 422:454-61. 2012..RA-incorporated GC nanoparticles were evidently inhibited the proliferation of HuCC-T1 cholangiocarcinoma cells at higher than 20 μg/ml of RA concentration while empty GC vegicles did not affect to the viablity of ..
- L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinomaJeong Ki Min
Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungnam National University School of Medicine, Daejon, Korea
Clin Cancer Res 16:3571-80. 2010Intrahepatic cholangiocarcinoma (ICC), a highly malignant hepatobiliary cancer, has a poor prognosis and is refractory to conventional therapies. The aim of this study is to discover a novel molecular target for the treatment of ICC.
- Risk factors for intrahepatic cholangiocarcinoma: a possible role of hepatitis B virusM Tanaka
Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
J Viral Hepat 17:742-8. 2010There are several established risk factors for intrahepatic cholangiocarcinoma (ICC), namely primary sclerosing cholangitis, fibropolycystic liver disease, parasitic infection, intrahepatic biliary stones and chemical carcinogen exposure...
- Phase II study of hepatic intraarterial epirubicin and cisplatin, with systemic 5-fluorouracil in patients with unresectable biliary tract tumorsMaurizio Cantore
Department of Oncology, Massa Carrara City Hospital, Massa Carrara, Italy
Cancer 103:1402-7. 2005....
- Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasoundLi Da Chen
Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat Sen University, 58 Zhongshan Road 2, Guangzhou 510080, China
Eur Radiol 20:743-53. 2010We assessed the usefulness of contrast-enhanced ultrasound (CEUS) in the differentiation of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).
- Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysisWei Jing
Department of General Surgery, Changhai Hospital of Second Military Medical University, Shanghai, China
Eur J Cancer Prev 21:24-31. 2012..However, its relationship with cholangiocarcinoma (CC), which includes intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), ..
- Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinomaAbdul M Oseini
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Hepatology 54:940-8. 2011..Many patients with IAC present with biliary strictures and obstructive jaundice, making cholangiocarcinoma (CCA) an important differential diagnosis. We determined the value of sIgG4 in distinguishing IAC from CCA...
- Initial performance profile of a new 6F self-expanding metal stent for palliation of malignant hilar biliary obstructionJennifer Chennat
Center for Endoscopic Research and Therapeutics, Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
Gastrointest Endosc 72:632-6. 2010..A 6F endoscopic biliary self-expanding metal stent (SEMS) has been newly introduced for intended simultaneous side-by-side bilateral deployment in hilar malignant obstruction...
- Cholangiocarcinoma: a compact review of the literatureYucel Ustundag
Department of Internal Medicine, Gastroenterology Clinic, School of Medicine, Hacettepe University, Ankara 06100, Turkey
World J Gastroenterol 14:6458-66. 2008b>Cholangiocarcinoma (CC) is a devastating cancer arising from biliary epithelia. Unfortunately, the incidence of this disease is increasing in Western countries...
- Mimics of cholangiocarcinoma: spectrum of diseaseChristine O Menias
Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, MO, USA
Radiographics 28:1115-29. 2008b>Cholangiocarcinoma is the second most common primary malignant hepatobiliary neoplasm, accounting for approximately 15% of liver cancers...
- Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3Guan Hua Lai
Division of Cellular and Molecular Pathogenesis, Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298 0297, USA
Mol Cancer Ther 2:265-71. 2003..inhibitor, effectively blocked tyrosine phosphorylation of p185(neu) overexpressed in cultured rat C611B cholangiocarcinoma (ChC) cells and in neu-transformed WB-F344 rat-liver epithelial stem-like cells (WBneu cells)...
- Liver transplantation for cholangiocarcinomaCharles B Rosen
Division of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA
Transpl Int 23:692-7. 2010..high dose neoadjuvant radiotherapy with chemosensitization achieves excellent results for patients with early stage, unresectable hilar cholangiocarcinoma or cholangiocarcinoma arising in the setting of primary sclerosing cholangitis.
- Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignanciesEdgar Ben-Josef
Department of Radiation Oncology, Division of Hematology Oncology, University of Michigan, UH B2C490, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0010, USA
J Clin Oncol 23:8739-47. 2005..A phase II trial was conducted to determine if high-dose radiation with concurrent hepatic arterial floxuridine would improve survival in patients with unresectable intrahepatic malignancies...
- Role of epigenetic alterations in cholangiocarcinomaIris Tischoff
Institute of Pathology, University of Leipzig, D 04103, Leipzig, Germany
J Hepatobiliary Pancreat Surg 13:274-9. 2006..At present, little is known about the cellular and molecular mechanisms leading to the development of cholangiocarcinoma. In recent years, in addition to genetic alterations, epigenetic inactivation of (tumor suppressor) genes by ..
- Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor)Sander Dinant
Department of Surgery, Academic Medical Center, P O Box 22700, 1100, DE, Amsterdam, The Netherlands
Ann Surg Oncol 13:872-80. 2006Treatment of hilar cholangiocarcinoma (Klatskin tumors) has changed in many aspects...
- Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic markerKusumawadee Utispan
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok Noi, Bangkok 10700, Thailand
Mol Cancer 9:13. 2010Fibroblasts play important roles in several cancers. It was hypothesized that cholangiocarcinoma (CCA)-associated fibroblasts (Cfs) differ from non-tumorigenic liver fibroblasts (Lfs) in their gene expression profiles resulting in the ..
- Detection of cholangiocarcinoma in vivo using miniprobe-based confocal fluorescence microscopyAlexander Meining
Department of Medicine II, Technical University of Munich, Munich, Germany
Clin Gastroenterol Hepatol 6:1057-60. 2008The preoperative diagnosis of cholangiocarcinoma is associated with a low sensitivity. To overcome this limitation, a new imaging modality was evaluated to detect neoplasia in vivo in the biliary tract.
- Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinomaJun Sato
Department of Organ Regenerative Surgery, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960 1295, Japan
J Hepatobiliary Pancreat Sci 18:700-11. 2011Gemcitabine is a promising drug for cholangiocarcinoma treatment. However, the kinetics and metabolism of this drug in cholangiocarcinoma treatment are not well defined...
- Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: a nested case-control studyKirati Poomphakwaen
Dept of Epidemiology, Faculty of Public Health, Mahidol University, Bangkok, Thailand
Asian Pac J Cancer Prev 10:251-8. 2009..present nested case-control study within the Khon Kaen cohort study was conducted to assess risk factors for cholangiocarcinoma (CCA) development...
- Photodynamic therapy for unresectable cholangiocarcinomaYutaka Tomizawa
Department of Medicine, University of Pittsburgh Medical Center, 5230 Center Avenue, Pittsburgh, PA 15232, USA
Dig Dis Sci 57:274-83. 2012b>Cholangiocarcinoma (CC) is a rare primary malignancy of the biliary tract with a dismal prognosis. Curative resection can only be applied to a small proportion of early diagnosed patients...
- Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cellChung Wook Chung
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
Eur J Pharm Biopharm 80:453-8. 2012Photodynamic therapy (PDT) is a palliative therapy and has been used to cure cholangiocarcinoma (CC), which has a poor prognosis and limited available curative therapy...
- Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinomaHyun Goo Woo
Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
Cancer Res 70:3034-41. 2010Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers...
- Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidenceF Zhang
Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Histopathology 52:224-32. 2008Combined hepatocellular cholangiocarcinoma (CHC) is a rare form of primary liver cancer, showing a mixture of hepatocellular and biliary features. Data suggest that most CHC arise from hepatic progenitor cells (HPCs)...
- Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and AktChang Han
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 280:24053-63. 2005..This study was designed to examine the mechanisms by which COX-2-derived prostaglandin E2 (PGE2) regulates cholangiocarcinoma cell growth and invasion...
- GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREEGIANFRANCO D ALPINI; Fiscal Year: 2010..liver diseases (cholangiopathies) such as primary biliary cirrhosis, primary sclerosing cholangitis, and cholangiocarcinoma. Cholangiopathies cause morbidity and mortality and are a major public health concern leading to liver ..
- Role of liver fluke granulin in cholangiocarcinogenesisJason P Mulvenna; Fiscal Year: 2013..food-borne liver fluke parasites Opisthorchis viverrini and Clonorchis sinensis is a strong risk factor for cholangiocarcinoma (CCA), bile duct cancer, in Thailand, Laos and other locations in East Asia where infection is endemic...
- Access to Liver Transplantation for Patients with Primary Sclerosing CholangitisDavid Seth Goldberg; Fiscal Year: 2011..with PSC face unique complications as compared to other patients with end-stage liver disease, including cholangiocarcinoma (CCA), cholangitis from biliary strictures, and complications such as colon cancer from concomitant ..
- Partial-wave spectroscopic microscopy for the diagnosis of cholangiocarcinomaYang Liu; Fiscal Year: 2010..biophotonics technology - partial-wave spectroscopic microscopy (PWS) for the diagnosis and surveillance of cholangiocarcinoma (CCA). CCA is a primary malignancy in bile duct epithelium...
- A novel diagnostic biomarker for hepatocellular carcinoma and cholangiocarcinomaXuanyong Lu; Fiscal Year: 2012....
- cPLA2alpha and COX-2 in CholangiocarcinomaTong Wu; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cholangiocarcinoma is a highly malignant neoplasm of the biliary tract and its incidence and mortality is rising...
- Calmodulin Regulates Fas-Mediated Apoptosis: A Target for Cancer TherapyJay M McDonald; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cholangiocarcinoma is a highly malignant tumor that arises from cholangiocytes of the intra- and extra-hepatic biliary system...
- MicroRNA involvement in the regulation of biliary epitheliumFlorin Selaru; Fiscal Year: 2013..The reason for this restriction is that we plan on using the SMAD4/PTEN murine model of cholangiocarcinoma for our in vivo studies. Next, we propose to 2...
- A confocal endomicroscope for clinical researchMichael H Nathanson; Fiscal Year: 2010..secretion and proliferation in disorders characterized by mucosal inflammation, and lymphangiogenesis in cholangiocarcinoma and in other biliary tract diseases...
- Mechanisms of Carcinogenesis in Biliary EpitheliaGregory J Gores; Fiscal Year: 2013..the cellular mechanisms contributing to the development and progression of biliary tract cancer, termed cholangiocarcinoma (CCA)...
- Biomarkers of Opisthorchis viverrini-induced cholangiocarcinomaPaul J Brindley; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cholangiocarcinoma (CCA) - bile duct cancer - is associated with late presentation, poses challenges for diagnosis and has high mortality, features that highlight the need for biomarkers than can be ..
- Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in ThailandBanchob Sripa; Fiscal Year: 2013..Chronic opisthorchiasis often culminates cholangiocarcinoma, cancer of the bile ducts...
- Mechanisms of Survival Signaling in Biliary EpitheliaTushar Patel; Fiscal Year: 2013..Chronic biliary tract inflammation predisposes to cholangiocarcinoma formation...
- PSC Resource Of Genetic Risk, Environment and Synergy Studies (PROGRESS)Konstantinos N Lazaridis; Fiscal Year: 2013..to lack of medical therapy, advancement to end-stage liver disease and an increased risk of colon cancer and cholangiocarcinoma (CCA). Thus, while rare in the population, PSC is a notable threat to patients with IBD...
- Apoptosis Effectors Targeted By Hedgehog-Supported MicroRNAsJustin L Mott; Fiscal Year: 2012..OBJECTIVES of this project are to understand the altered regulation of microRNAs by oncogenic signals in cholangiocarcinoma, and how microRNAs contribute to cell death resistance...
- Cholangiocyte microRNAs Regulate Mcl-1 and Cell DeathJustin L Mott; Fiscal Year: 2011..This proposal outlines a testable hypothesis to define the role of microRNAs as regulators of apoptosis in cholangiocarcinoma, a malignant neoplasm that occurs in the presence of chronic inflammation of bile ducts...
- Genetics pathways in intra-hepatic cholangiocarcinomaAram F Hezel; Fiscal Year: 2013DESCRIPTION (provided by applicant): Intra-hepatic cholangiocarcinoma (IHCC) is a primary cancer of the liver with a rising incidence and poor outcomes that have improved only marginally in recent decades...
- ALTERED GROWTH FACTOR PATHWAYS IN BILIARY CANCERAlphonse E Sirica; Fiscal Year: 2013DESCRIPTION (provided by applicant): Intrahepatic cholangiocarcinoma (ICC) is a highly malignant primary neoplasm that is considered to be clinically important and therapeutically challenging due to its increasing incidence, high ..
- Pathogenesis of Liver Fluke Induced Cancer in ThailandPaul Brindley; Fiscal Year: 2009..There is no stronger link between a human malignancy and a parasitic infection than the link between cholangiocarcinoma (CCA)-hepatic cancer of the bile duct epithelia-and infection with the liver fluke, Opisthorchis viverrini...
- Biliary oxysterols and cholangiocarcinomaRAHUL P KUVER; Fiscal Year: 2010There is a worldwide and steady increase in the incidence of cholangiocarcinoma, a malignancy with very limited treatment options and high mortality...
- Protein interactions underlying Fas-mediated DISC in CholangiocarcinomaYuhua Song; Fiscal Year: 2013..b>Cholangiocarcinoma is a fatal cancer and its rates have been rising worldwide over the past several decades...
- Primary Cilia and Malignant TransformationSergio A Gradilone; Fiscal Year: 2013..Our preliminary data shows the absence of cilia in cholangiocarcinoma cells;therefore, ciliary dysfunction may be associated with cancer development...
- Aberrant kinase signaling in cholangiocarcinomaTushar Patel; Fiscal Year: 2003..vitro studies on human normal and malignant cholangiocyte cells in culture and an in vivo xenograft model of cholangiocarcinoma. These studies will help us to elucidate the role of p38 MAPK signaling in the growth and spread of ..
- Mechanisms of Carcinogenesis in Biliary EpitheliaGregory Gores; Fiscal Year: 2006..Chronic inflammation of the biliary tree predisposes to the development of cholangiocarcinoma, a malignant neoplasm originating from cholangiocytes...
- DYSREGULATION OF CHOLANGIOCYTE APOPTOSIS BY CYTOKINESTushar Patel; Fiscal Year: 2003..condition affecting the biliary system, is associated with cytokine alterations and the development of cholangiocarcinoma. Dysregulation of apoptosis has recently been implicated as an important contributor to carcinogenesis...
- Development of Immunodiagnostics for Pancreatic CancerHossein Ghanbari; Fiscal Year: 2002..of malignant tumors, including pancreatic carcinoma, glioblastoma multiforme, hepatocellular carcinoma, and cholangiocarcinoma. Additionally, unlike other potential tumor markers, over-expression of HAAH displays high specificity for ..
- Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic MalignancyWilliam Jarnagin; Fiscal Year: 2008..this protocol targets patients with unresectable hepatocellular carcinoma (HCC) or intrahepatic (peripheral) cholangiocarcinoma (ICC) for continuous infusion of floxuridine (FUDR) combined with systemic bevacizumab...
- Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver BiologySusanne Keiding; Fiscal Year: 2010..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..
- Nonalcoholic steatohepatitis and Cytochrome P450 EnzymesNaga P Chalasani; Fiscal Year: 2010..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
- BILIARY SECRETORY PATHWAYS IN CYSTIC FIBROSISWon Kyoo Cho; Fiscal Year: 2003..abstract_text> ..
- FDG PET-CT in Metastatic Prostate CancerHossein Jadvar; Fiscal Year: 2010..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
- MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASEJoseph Avruch; Fiscal Year: 2011..The results of these studies will provide basis for therapeutic interventions in this pathway, which is crucial to both human cancers and to diseases like Type 2 diabetes ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- The Role of RR in Chemotherapeutic Drug ResistanceYun Yen; Fiscal Year: 2005..Taken together, our proposed studies will provide an integrated evaluation of the molecular control of RR-mediated chemotherapeutic drug resistance. ..
- Genetic Basis of Colon Adenoma Synchronous to Carcinoma.Yun Yen; Fiscal Year: 2005..We will understand better the biology of different subsets of sporadic CRC, namely CRC+SA, proximal tumors and MSI instable tumors. Our findings will impact on future clinical therapeutic studies of CRC. ..
- Evaluation of Biliary Strictures by IDUS, DIA, and FISHMichael Levy; Fiscal Year: 2005..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
- Wnt Signaling in IBD-Related Colon CancerRANDALL HOLCOMBE; Fiscal Year: 2005..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
- HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTIONChangyi Chen; Fiscal Year: 2004..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
- Hepatic engraftment of marrow cells in mice and humansNeil Theise; Fiscal Year: 2004....
- Volume Regulatory Pathways in Cystic Fibrosis MiceWon Kyoo Cho; Fiscal Year: 2003..abstract_text> ..
- HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIAChangyi Chen; Fiscal Year: 2002....
- Oxidative mutagenesis:Iron, Ascorbic Acid and GenesChristopher Bowlus; Fiscal Year: 2002..They will use a mouse model of HH that is prone to hepatocellular formation. ..
- BONE MARROW AS A SOURCE FOR PANCREATIC STEM CELLSBryon Petersen; Fiscal Year: 2002..The same data could potentially provide a valuable resource for future tissue engineering and cell therapy technique interventions in pancreatic regeneration. ..
- Effects of HIV Protease Inhibitors of Endothelial BarrieChangyi Chen; Fiscal Year: 2005..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
- Molecular Surgeon Symposium on Vascular Injury, RepairChangyi Chen; Fiscal Year: 2005..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
- A Phase 1 Study of CCI-779 in Combination with Imatnib *RANDALL HOLCOMBE; Fiscal Year: 2006..Since deregulated kinase activity is known to contribute to a wide range of malignancies, these studies will have applicability to cancer therapy in general. [unreadable] [unreadable]..
- Effects of HAART drugs on endothelial dysfunction of pu*Changyi Chen; Fiscal Year: 2009..abstract_text> ..
- Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation DetectorsSam Beddar; Fiscal Year: 2009..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
- Listeria Monocytogenes to Treat Hepatic MetastasesRichard Schulick; Fiscal Year: 2009..Specific Aim 4: Define the role of dendritic cells in the priming and targeting of the immune response. ..
- GM-CSF Enhanced Colorectal Cancer Tumor Vaccine ProgramRichard Schulick; Fiscal Year: 2008..abstract_text> ..
- Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic CancerChangyi Chen; Fiscal Year: 2008..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
- Targeting AKT as a novel therapy in pancreatic cancerRichard Bold; Fiscal Year: 2007..These results will provide mechanistic as well as pre-clinical data in support of our hypothesis and will allow for the development of novel therapy of human pancreatic cancer. [unreadable] [unreadable] [unreadable]..
- Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)Christian Schmidt; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Occult Hepatitis BMichael Torbenson; Fiscal Year: 2007..abstract_text> ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- Tissue engineering of small diameter vascular graftChangyi Chen; Fiscal Year: 2006..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
- ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSIONChangyi Chen; Fiscal Year: 2002....