carcinoma

Summary

Summary: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

Top Publications

  1. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
  2. ncbi Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    Jason J Christiansen
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cancer Res 66:8319-26. 2006
  3. doi EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013
    Marko Babjuk
    Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic
    Eur Urol 64:639-53. 2013
  4. pmc The mutational landscape of head and neck squamous cell carcinoma
    Nicolas Stransky
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Science 333:1157-60. 2011
  5. ncbi miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    Silvia Galardi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    J Biol Chem 282:23716-24. 2007
  6. doi Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
    Karen A Gelmon
    BC Cancer Agency, Vancouver, Canada
    Lancet Oncol 12:852-61. 2011
  7. pmc IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    Romaine I Fernando
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 71:5296-306. 2011
  8. doi Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells
    Chen Yang
    Center for Molecular Medicine, The First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, 76 West Yanta Road, 710061 Xi an, China
    Gene 496:8-16. 2012
  9. ncbi Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
  10. pmc Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells
    Wesley M Konsavage
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:11730-9. 2012

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. Yasmin Wadia; Fiscal Year: 2014
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
  4. Yun Fai Chris Lau; Fiscal Year: 2014
  5. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
  6. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
  7. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
  8. BRIAN JAMES MCMAHON; Fiscal Year: 2016
  9. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
  10. Bayar Thimmapaya; Fiscal Year: 2016

Detail Information

Publications489 found, 100 shown here

  1. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost...
  2. ncbi Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    Jason J Christiansen
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cancer Res 66:8319-26. 2006
    ..and describe mechanisms to explain the morphologic and molecular heterogeneity and plasticity of malignant carcinoma cells, including incomplete EMT, reversion to an epithelial phenotype, and collective migration...
  3. doi EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013
    Marko Babjuk
    Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic
    Eur Urol 64:639-53. 2013
    ..The first European Association of Urology (EAU) guidelines on bladder cancer were published in 2002 [1]. Since then, the guidelines have been continuously updated...
  4. pmc The mutational landscape of head and neck squamous cell carcinoma
    Nicolas Stransky
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Science 333:1157-60. 2011
    Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs...
  5. ncbi miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    Silvia Galardi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    J Biol Chem 282:23716-24. 2007
    ..miR-222, encoded in tandem on chromosome X, are overexpressed in the PC3 cellular model of aggressive prostate carcinoma, as compared with LNCaP and 22Rv1 cell line models of slowly growing carcinomas...
  6. doi Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
    Karen A Gelmon
    BC Cancer Agency, Vancouver, Canada
    Lancet Oncol 12:852-61. 2011
    ..We aimed to assess the safety and tolerability of this drug in patients without BRCA1 or BRCA2 mutations with advanced triple-negative breast cancer or high-grade serous and/or undifferentiated ovarian cancer...
  7. pmc IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    Romaine I Fernando
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 71:5296-306. 2011
    ..Here we show that induction of EMT in human carcinoma cells via overexpression of the transcription factor Brachyury is associated with enhanced secretion of multiple ..
  8. doi Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells
    Chen Yang
    Center for Molecular Medicine, The First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, 76 West Yanta Road, 710061 Xi an, China
    Gene 496:8-16. 2012
    Long non-coding RNA urothelial carcinoma associated 1 (UCA1) promotes human bladder cancer cell proliferation, but the underlying mechanism remains unknown...
  9. ncbi Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
    Incidence of nasopharyngeal carcinoma has remained high in endemic regions...
  10. pmc Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells
    Wesley M Konsavage
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:11730-9. 2012
    ..Together, these results implicate YAP as an oncogene whose expression is driven by aberrant Wnt/β-catenin signaling in human CRC cells...
  11. pmc Ovarian carcinoma subtypes are different diseases: implications for biomarker studies
    Martin Köbel
    Department of Pathology, Genetic Pathology Evaluation Centre of the Prostate Research Centre, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Med 5:e232. 2008
    Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment ..
  12. ncbi Focus on nasopharyngeal carcinoma
    Kwok Wai Lo
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cancer Cell 5:423-8. 2004
  13. pmc Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
    Krystian Jazdzewski
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, 850 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:7269-74. 2008
    Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found...
  14. doi Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial
    Jean Pascal Machiels
    Cliniques Universitaires Saint Luc, Brussels, Belgium
    Lancet Oncol 12:333-43. 2011
    No treatments are presently available to increase survival in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy...
  15. doi MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening
    Sven Wach
    University Clinic of Urology, Friedrich Alexander University Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Int J Cancer 130:611-21. 2012
    ..Our results indicate that combinations of miRNAs are promising biomarkers for the diagnosis of prostate cancer...
  16. pmc Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis
    Ie Ming Shih
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 164:1511-8. 2004
    The pathogenesis of ovarian carcinoma, the most lethal gynecological malignancy, is unknown because of the lack of a tumor progression model...
  17. ncbi Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer
    M Morris
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 340:1137-43. 1999
    ..Patients were then to receive one or two applications of low-dose-rate intracavitary radiation, with a third cycle of chemotherapy planned for the second intracavitary procedure in the combined-therapy group...
  18. ncbi Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    W T Creasman
    Int J Gynaecol Obstet 95:S105-43. 2006
  19. ncbi Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group
    David G Jayne
    Academic Unit of Surgery, St James s University Hospital, Leeds, United Kingdom
    J Clin Oncol 25:3061-8. 2007
    ..Few data are available on rectal cancer, and long-term data on survival and recurrence are now required...
  20. doi Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis
    HuiPing Xue
    Department of Gastroenterology, Shanghai Institute of Gastrointestinal Diseases, Shanghai, China
    J Gastroenterol Hepatol 25:1604-17. 2010
    ..IL)-1B cluster gene polymorphisms at positions -511, -31, and +3954 and the receptor IL-1RN variable number tandem repeat polymorphisms in the susceptibility to gastric carcinoma through a systematic review and meta-analysis.
  21. ncbi Intraperitoneal cisplatin and paclitaxel in ovarian cancer
    Deborah K Armstrong
    Johns Hopkins Kimmel Cancer Center, Baltimore, USA
    N Engl J Med 354:34-43. 2006
    ..The Gynecologic Oncology Group conducted a randomized, phase 3 trial that compared intravenous paclitaxel plus cisplatin with intravenous paclitaxel plus intraperitoneal cisplatin and paclitaxel in patients with stage III ovarian cancer...
  22. pmc Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
    Vlad C Sandulache
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA
    Cancer 117:2926-38. 2011
    ..An understanding of the metabolic phenotype of head and neck squamous cell carcinoma (HNSCC) will allow the development of appropriate antimetabolic strategies for this tumor type.
  23. pmc Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    Nishant Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Science 333:1154-7. 2011
    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors...
  24. doi The prognostic significance of tumor-associated stroma in invasive breast carcinoma
    Soomin Ahn
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul, 135 710, South Korea
    Tumour Biol 33:1573-80. 2012
    ..In this study, we analyzed surgically resected specimens from 545 patients with breast carcinoma, including 193 high-grade tumors, for tumor-stroma ratio, dominant stroma type [collagen (C), fibroblast (F), or ..
  25. ncbi Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation
    Michael K M Kam
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 56:145-57. 2003
    ..IMRT) with two-dimensional RT (2D-RT) and three-dimensional conformal radiotherapy (3D-CRT) treatment plans in different stages of nasopharyngeal carcinoma and to explore the feasibility of dose escalation in locally advanced disease.
  26. ncbi Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer
    Vic J Verwaal
    Department of Surgery, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Clin Oncol 21:3737-43. 2003
    ....
  27. ncbi Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    J Clin Oncol 23:6966-75. 2005
    This randomized study compared the results achieved by concurrent chemoradiotherapy (CRT) versus radiotherapy (RT) alone for nasopharyngeal carcinoma (NPC) with advanced nodal disease.
  28. ncbi Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance
    Anamaria Brozovic
    Division of Applied Toxicology, Institute of Toxicology, Mainz, Germany
    Int J Cancer 112:974-85. 2004
    ..ACR cells displayed a reduced level of DNA damage, indicating long-term stimulation of SAPK/JNK and p38 kinase is triggered by nonrepaired cDDP-induced DNA lesions...
  29. ncbi Molecular characterization of human prostate carcinoma cell lines
    Adrie van Bokhoven
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Prostate 57:205-25. 2003
    This study presents a comprehensive survey and characterization of available prostate carcinoma cell lines, most of which have been widely used but are incompletely characterized.
  30. ncbi Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
    Sudheer K Mantena
    Department of Dermatology, University of Alabama at Birmingham, Volker Hall 557, 1670 University Boulevard, P O Box 202, Birmingham, AL 35294, USA
    Mol Cancer Ther 5:296-308. 2006
    ....
  31. ncbi Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    A P M Heintz
    Int J Gynaecol Obstet 95:S161-92. 2006
  32. pmc The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
    Neri Mercatelli
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 3:e4029. 2008
    ..We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity.
  33. pmc Dysplasia-carcinoma transition specific transcripts in colonic biopsy samples
    Orsolya Galamb
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    PLoS ONE 7:e48547. 2012
    The early molecular detection of the dysplasia-carcinoma transition may enhance the strength of diagnosis in the case of colonic biopsies...
  34. pmc β-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma
    Jeffrey C Francis
    Division of Cancer Biology, Institute of Cancer Research, London, United Kingdom
    PLoS Genet 9:e1003180. 2013
    ..Catenin overexpression in combination with Pten loss was able to drive progression to invasive carcinoma together with squamous metaplasia...
  35. doi Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    Jihène Klibi
    Universite Paris Sud, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8126, Paris, France
    Blood 113:1957-66. 2009
    Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is the third most frequent virus-associated human malignancy...
  36. doi Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer
    F C Bidard
    CirCe laboratory, Institut Curie, 26 Rue d Ulm, Paris, France
    Ann Oncol 21:729-33. 2010
    ..In this prospective study, we reported the clinical outcome of nonmetastatic breast cancer patients according to CTC detection...
  37. doi New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation
    Fengyan Jin
    The First Hospital of Jilin University, Changchun, China
    Mol Cancer Res 10:1021-31. 2012
    ..in human umbilical vein and dermal microvascular endothelial cells (HUVEC and HDMEC) and in cultured mammary carcinoma cells (MDA MB231, and MCF7)...
  38. pmc Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma
    Lei Ma
    Cancer Institute, Southern Medical University, Guangzhou, China
    FEBS J 280:2027-41. 2013
    ..receptor (EGFR) pathway plays a critical role in regulating cancer stem-like cells (CSCs) in nasopharyngeal carcinoma (NPC), one of the most common malignant tumors in Southeast Asia...
  39. pmc Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells
    Tapati Mazumdar
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 71:5904-14. 2011
    ..In human colon carcinoma cells, treatment with the Gli small-molecule inhibitor GANT61 induces extensive cell death in contrast to the ..
  40. doi DNA methylation markers in colorectal cancer
    Myoung Sook Kim
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 5M, Baltimore, MD, 21231, USA
    Cancer Metastasis Rev 29:181-206. 2010
    ..Therefore, the aim of this review is to understand DNA methylation as a driving force in colorectal neoplasia and its emerging value as a molecular marker in the clinic...
  41. pmc Repeated observation of breast tumor subtypes in independent gene expression data sets
    Therese Sorlie
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:8418-23. 2003
    ..Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities...
  42. ncbi The enigmatic epidemiology of nasopharyngeal carcinoma
    Ellen T Chang
    Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 15:1765-77. 2006
    Nasopharyngeal carcinoma (NPC) has a unique and complex etiology that is not completely understood...
  43. doi Early events in the pathogenesis of epithelial ovarian cancer
    Charles N Landen
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030, USA
    J Clin Oncol 26:995-1005. 2008
    ....
  44. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    ..These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors...
  45. pmc Drug-sensitive FGFR2 mutations in endometrial carcinoma
    Amit Dutt
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8713-7. 2008
    ..gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma...
  46. doi Detection and characterisation of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging
    D Lowenthal
    Department of Radiology and Nuclear Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Radiol 21:832-40. 2011
    To compare diffusion-weighted imaging (DWI) and Gd-EOB-DTPA-enhanced magnetic resonance (MR) imaging for the detection and characterisation of focal liver lesions (FLLs) in patients with colorectal carcinoma.
  47. ncbi PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
    Jong Woo Lee
    Department of Pathology, College of Medicine, Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, Korea
    Oncogene 24:1477-80. 2005
    ..3%). Some of the PIK3CA mutations were detected in the early lesions of breast cancer carcinoma, hepatocellular carcinoma, and gastric carcinomas, suggesting that PIK3CA mutation may occur independent of ..
  48. doi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  49. pmc A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis
    Ulrike Philippar
    Massachusetts Institute of Technology, Koch Institute, Cambridge, MA 02139, USA
    Dev Cell 15:813-28. 2008
    ..Here we show that Mena and Mena(INV) promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis...
  50. pmc Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB
    Chun Yan Li
    Biotherapy Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    J Transl Med 7:56. 2009
    ....
  51. ncbi RAS is regulated by the let-7 microRNA family
    Steven M Johnson
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 120:635-47. 2005
    ..let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer...
  52. ncbi HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma
    Marie Luise Brezniceanu
    Chemotherapeutisches Forschungsinstitut, Georg Speyer Haus, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    FASEB J 17:1295-7. 2003
    ..We found high HMGB1 protein levels in human primary breast carcinoma. Hmgb1 RNA levels are changing during different stages of mouse mammary gland development and are particularly ..
  53. doi Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin
    Dominique Elias
    Département de Chirurgie Carcinologique, Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 27:681-5. 2009
    ....
  54. pmc Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3
    Ka Po Tse
    Genomic Medicine Core, Chang Gung Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Am J Hum Genet 85:194-203. 2009
    Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated with genetic factors and Epstein-Barr virus infection...
  55. pmc Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
    N M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Cell Death Dis 1:e85. 2010
    ..Using nasopharyngeal carcinoma (NPC) as a disease model, a comprehensive analysis was undertaken on the clinical significance of EZH2 ..
  56. doi IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma
    Jiankun Liu
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    Biochem Biophys Res Commun 407:348-54. 2011
    ..the relevance of IL-17 to clinical parameters and its function in the development and progression of colorectal carcinoma still remain to be explored...
  57. ncbi Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study
    O Glehen
    Centre Hospitalo Universitaire Lyon Sud, Pierre Benite, France
    J Clin Oncol 22:3284-92. 2004
    ..New approaches combining cytoreductive surgery and perioperative intraperitoneal chemotherapy suggest improved survival...
  58. ncbi Epithelial-mesenchymal transitions in development and pathologies
    Jean Paul Thiery
    Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Opin Cell Biol 15:740-6. 2003
    ..This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of ..
  59. ncbi Pilot intervention to enhance sexual rehabilitation for couples after treatment for localized prostate carcinoma
    Andrea L Canada
    Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
    Cancer 104:2689-700. 2005
    The majority of prostate carcinoma survivors experience enduring sexual difficulties and associated distress in the years after definitive treatment...
  60. ncbi Increasing incidence of thyroid cancer in the United States, 1973-2002
    Louise Davies
    VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, VT 05009, USA
    JAMA 295:2164-7. 2006
    ..Changes in the diagnostic approach to thyroid nodules may have resulted in an increase in the apparent incidence of thyroid cancer...
  61. ncbi High-dose-rate intracavitary brachytherapy boost for early T stage nasopharyngeal carcinoma{private}
    To Wai Leung
    Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, People s Republic of China
    Int J Radiat Oncol Biol Phys 70:361-7. 2008
    To investigate any possible therapeutic gain from dose escalation with brachytherapy for early T stage nasopharyngeal carcinoma (NPC).
  62. doi MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways
    W Qin
    Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing, China
    Oncogene 31:4067-75. 2012
    We report that elevated microRNA-133b (miR-133b) acts as an oncogene in human cervical carcinoma to promote tumorigenesis and metastasis...
  63. doi Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma
    Feng Yang
    Department of General Surgery, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Zhizaoju Road No 639, Shanghai 200011, China
    J Cancer Res Clin Oncol 139:437-45. 2013
    ..The specific aim of this study was to determine the role of a long noncoding RNA CCAT1 in the progression of gastric carcinoma and discover which factors contribute to the deregulation of CCAT1.
  64. doi L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells
    Li Chuan Chung
    Department of Bioengineering, Tatung University, Taipei, Taiwan, Republic of China
    Am J Physiol Cell Physiol 302:C676-85. 2012
    ..We evaluated the molecular mechanisms of L-mimosine on cell cycle modulation in PC-3 and LNCaP prostate carcinoma cells...
  65. ncbi Distant metastases in ovarian carcinoma
    G Cormio
    Gynecologic Oncology Unit, University of Bari, Bari, Italy
    Int J Gynecol Cancer 13:125-9. 2003
    Distant metastases are unusual at presentation and during the course of ovarian carcinoma. The aim of the present study was to determine the incidence and prognostic factors of distant metastases consistent with stage IV disease in ..
  66. doi Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    Mhairi A Morris
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Future Oncol 5:811-25. 2009
    ..the contribution of the oncogenic latent membrane protein-1 (LMP1) to the pathogenesis of nasopharyngeal carcinoma remains to be fully defined...
  67. pmc Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
    Laurie L Carr
    Division of Medical Oncology, National Jewish Health, Denver, Colorado, USA
    Clin Cancer Res 16:5260-8. 2010
    ..of sunitinib in patients with flurodeoxyglucose positron emission tomography (FDG-PET)-avid, iodine-refractory well-differentiated thyroid carcinoma (WDTC) and medullary thyroid cancer (MTC) and to assess for early response per FDG-PET.
  68. doi Human epididymis protein 4 (HE4) as a serum tumor biomarker in patients with ovarian carcinoma
    Xiaohong Chang
    Gynecology Oncology Center, Peking University People s Hospital, Beijing, China
    Int J Gynecol Cancer 21:852-8. 2011
    ..This study evaluated human epididymis protein 4 (HE4), a novel ovarian cancer biomarker, both alone and in combination with CA 125 as a diagnostic marker for ovarian cancer in a Chinese population...
  69. ncbi Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    W Jeffrey Allard
    Immunicon Corporation, Huntingdon Valley, Pennsylvania 19006, USA
    Clin Cancer Res 10:6897-904. 2004
    ..5 mL of blood in healthy subjects, patients with nonmalignant diseases, and patients with a variety of metastatic carcinomas...
  70. ncbi The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature
    J A Langendijk
    Department of Radiation Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Oncol 22:4604-12. 2004
    ..concurrent, and/or adjuvant chemotherapy to radiation in the treatment of locally advanced nasopharyngeal carcinoma (NPC) with regard to the overall survival (OS) and the incidence of local-regional recurrences (LRR) and distant ..
  71. ncbi Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?
    Erik W Thompson
    Invasion and Metastasis Unit, Department of Surgery, University of Melbourne and Embryology Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Cancer Res 65:5991-5; discussion 5995. 2005
  72. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    ..Down-regulation of Foxp3 with small interfering RNA (siRNA) in pancreatic carcinoma cells resulted in the up-regulation of interleukin 6 (IL-6) and IL-8 expression, providing evidence for a ..
  73. doi MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma
    C Yi
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    Oncogene 31:4421-33. 2012
    ..In this study, however, miR-663 was found to be upregulated in nasopharyngeal carcinoma (NPC) cells compared with human immortalized nasopharyngeal epithelium cells, using a miRNA microarray, and this ..
  74. doi Markers for individualised therapy in endometrial carcinoma
    Helga B Salvesen
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
    Lancet Oncol 13:e353-61. 2012
    ..FGFR) 2 as promising for further studies, also reflected in current clinical trials investigating endometrial carcinoma. A more systematic approach to integration of biomarkers in surgical trials and clinical trials of therapeutics, ..
  75. doi Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells
    Urszula M Polanska
    CR UK Stromal Tumour Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
    J Cell Physiol 228:1651-7. 2013
    Cancerous stroma coevolves alongside tumour progression, thereby promoting the malignant conversion of epithelial carcinoma cells...
  76. doi Analysis of the clinicopathologic features of papillary thyroid microcarcinoma based on 7-mm tumor size
    Kwan Ju Lee
    Department of Surgery, College of Medicine, The Catholic University of Korea, Daejeon St Mary s Hospital, 520 2, Daeheung dong, Jung Gu, Daejeon, South Korea
    World J Surg 35:318-23. 2011
    ..We examined the clinicopathologic features of papillary thyroid microcarcinomas (PTMCs) measuring≤7 mm and compared them with those of PTMCs>7 mm...
  77. pmc Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility
    Ning Yang
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705 2275, USA
    Am J Pathol 178:325-35. 2011
    ..In human breast carcinoma samples, stromal Sdc1 expression correlates with an organized, parallel, extracellular matrix (ECM) fiber ..
  78. pmc miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma
    Shujun Li
    Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300054, PR China
    J Biomed Sci 18:24. 2011
    ..To develop potential therapy targeting ARTN, we studied the roles of miR-223 in the migration and invasion of human esophageal carcinoma.
  79. ncbi Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:982-8. 2002
    ..physical examination alone in determining axillary lymph node involvement during preliminary staging of breast carcinoma. Due to occasional overlap of sonographic features of benign and indeterminate lymph nodes, fine-needle ..
  80. pmc Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, New Orleans, LA, USA
    J Exp Med 202:931-9. 2005
    ..However, the mechanisms that induce arginase I in MSCs in cancer are unknown. Using the 3LL mouse lung carcinoma, we aimed to characterize these mechanisms. Arginase I expression was independent of T cell-produced cytokines...
  81. ncbi Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    J Ying
    Cancer Epigenetics Laboratory, Sir YK Pao Cancer Center, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, and Department of Pathology, National University Hospital, Singapore
    Oncogene 25:1070-80. 2006
    ..pharmacologic demethylation, and identified the PCDH10 CpG island as a methylated sequence in nasopharyngeal carcinoma (NPC)...
  82. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma
    Ursula Plockinger
    Charite Universitatsmedizin, Campus Virchow Klinikum, Department of Hepatology and Gastroenterology, Berlin, Germany
    Neuroendocrinology 87:20-30. 2008
  83. ncbi A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
    Michael Overholtzer
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:966-79. 2007
    ....
  84. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated colon and rectum tumour/carcinoma
    John K Ramage
    Department of Gastroenterology, North Hampshire Hospital, Basingstoke, UK
    Neuroendocrinology 87:31-9. 2008
  85. ncbi Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    Premal H Thaker
    Department of Gynecologic Oncology, University of Texas U T M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, Texas 77030, USA
    Nat Med 12:939-44. 2006
    ..results in higher levels of tissue catecholamines, greater tumor burden and more invasive growth of ovarian carcinoma cells in an orthotopic mouse model...
  86. doi Prognostic factors and the therapeutic strategy for patients with bone metastasis from differentiated thyroid carcinoma
    Yorihisa Orita
    Department of Otolaryngology Head and Neck Surgery, Okayama Saiseikai General Hospital, Okayama, Japan
    Surgery 147:424-31. 2010
    ..Given the paucity of patients with bone metastasis and the difficulty of treating this disease, few studies have investigated the clinical features and prognostic factors of bone metastasis from differentiated thyroid cancer...
  87. doi Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
    Sylvain Ladoire
    Department of Medical Oncology, Centre Regional de Lutte Contre Cancer Georges François Leclerc, Dijon, France
    Breast Cancer Res Treat 125:65-72. 2011
    ..significance of Foxp3 expression in cancer cells in a large cohort of patients with HER2-overexpressing breast carcinoma treated with neoadjuvant chemotherapy...
  88. doi Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    Anja Apel
    Division of Radiobiology and Molecular Environmental Research, University of Tuebingen, Germany
    Cancer Res 68:1485-94. 2008
    ..majority of inhibited autophagy-related genes, each alone or combined, resulted in sensitization of resistant carcinoma cells to radiation, whereas untreated resistant cells but not sensitive cells survived better when autophagy was ..
  89. doi The microRNA profile of prostate carcinoma obtained by deep sequencing
    Jaroslaw Szczyrba
    Department of Virology, University of Saarland Medical School, Homburg Saar, Germany
    Mol Cancer Res 8:529-38. 2010
    ..Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer...
  90. ncbi Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review
    P Dulguerov
    Division of Head and Neck Surgery, Department of Surgery, University of California Los Angeles, Los Angeles, California, USA
    Cancer 92:3012-29. 2001
    The authors reviewed treatment results in patients with nasal and paranasal sinus carcinoma from a large retrospective cohort and conducted a systematic literature review.
  91. ncbi Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial
    Ka Lau Leung
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Lancet 363:1187-92. 2004
    Although laparoscopic resection of colorectal carcinoma improves post-operative recovery, long-term survival and disease control are the determining factors for its application...
  92. ncbi Epstein-Barr virus: 40 years on
    Lawrence S Young
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Cancer 4:757-68. 2004
    ..Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours...
  93. ncbi Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    Hiroaki Kajiyama
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Int J Oncol 31:277-83. 2007
    The aim of this study was to assess paclitaxel resistant-epithelial ovarian carcinoma (EOC) cells for cellular morphology, motility, and molecular changes consistent with epithelial-mesenchymal transition (EMT)...
  94. ncbi Prognostic significance of loss of c-fos protein in gastric carcinoma
    Seon Pil Jin
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Pathol Oncol Res 13:284-9. 2007
    ..The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos...
  95. doi The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  96. doi Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells
    Barbara De Berardis
    Department of Technology and Health, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy
    Toxicol Appl Pharmacol 246:116-27. 2010
    ..oxidative stress, apoptosis and proinflammatory mediator release induced by ZnO nanoparticles on human colon carcinoma LoVo cells. The biological activity of these particles was related to their physico-chemical characteristics...
  97. pmc Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells
    D M Smith
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, BSF218, Tampa, FL, USA
    Cell Death Differ 17:1867-81. 2010
    ..knockdown, siRNA targeting ATG5, ATG7, and hVps34 markedly reduced autophagy in As(2)O(3)-treated ovarian carcinoma cells...
  98. doi Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma
    Jaroslaw Szczyrba
    Institut fur Medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Haus 47, Universitatsklinikum, 66421 Homburg Saar, Germany
    Mol Cancer Res 9:791-800. 2011
    Prostate carcinoma (CaP) is a leading cause of cancer-related death in men. We have previously determined the microRNA (miRNA) profile of primary CaP in comparison with nontumor prostate tissue...
  99. doi The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 48:645-8. 2011
    FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown.
  100. doi MRI and CT of nasopharyngeal carcinoma
    Ahmed Abdel Khalek Abdel Razek
    Department of Diagnostic Radiology, Mansoura University Hospital, Faculty of Medicine, Elghomheryia St, Mansoura DK, Egypt
    AJR Am J Roentgenol 198:11-8. 2012
    This article reviews the MRI and CT of nasopharyngeal carcinoma. Extension of nasopharyngeal tumors, especially into the skull base and the deep facial spaces, is well illustrated on imaging...
  101. doi MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma
    Junji Kurashige
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Ann Surg Oncol 19:S656-64. 2012
    ..This study aimed to clarify the role of miR-200b in regulating EMT and promoting cellular proliferation, invasion, and migration in gastric cancer...

Research Grants133 found, 100 shown here

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Yasmin Wadia; Fiscal Year: 2014
    ..nephron-sparing surgery substitutes for radical nephrectomy in appropriately selected patients with renal cell carcinoma. Laparoscopic partial nephrectomy (LPN) has demonstrated excellent outcomes in terms of oncologic control, but ..
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..Our preliminary data demonstrated >50 fold higher level of TxRd1 in the human squamous carcinoma cell line FaDu compared to either an oral leukoplakia cell line MSK-Leuk1 or nontransformed keratinocytes...
  4. Yun Fai Chris Lau; Fiscal Year: 2014
    ..testicular germ cell tumors, prostate cancer, and sexual dimorphic cancers, such as hepatocellular carcinoma. TSPY potentiates cell proliferation, accelerates the transition and disrupts the G2/M checkpoints, binds cyclin ..
  5. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..Syn levels in the depressive rat model, WKY rat, and in endogenously expressing cells, such as the T-470 breast carcinoma cells...
  6. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Furthermore, UBC9 is overexpressed in several malignancies, such as lung adenocarcinoma, ovarian carcinoma, and melanoma...
  7. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathways have been identified...
  8. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..chronically infected with HBV and remain at an increased risk of disease sequelae including hepatocellular carcinoma.[10] Alaska Native persons chronically infected with HBV also exhibited increased incidence of hepatocellular ..
  9. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..cachexia;and 3) Characterize the effects of ghrelin in a tumor model of cachexia induced by the Lewis lung carcinoma (LLC) cell line...
  10. Bayar Thimmapaya; Fiscal Year: 2016
    ..Med1 also controls liver regeneration and the development of hepatocellular carcinoma (HCC), in that hepatocytes lacking Med1 fail to regenerate and fail to give rise to liver tumors...
  11. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..This hypothesis is based on our recent findings in colon and head and neck squamous carcinoma cell models that translational regulatory mechanisms inhibit tumor growth...
  12. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..nanospheres provides wide opportunities for the treatment of urologic diseases including transitional cell carcinoma of the bladder (TCC), interstitial cystitis (IC), overactive bladder, and detrusor hyperreflexia...
  13. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..to mammary gland ducts, combined with the known importance of collagenous matrix to the etiology of breast carcinoma and the up-regulation of col(V) in desmoplasia, have also prompted proposed studies into effects of 13(V) ..
  14. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The tumor microenvironment is responsible for stimulating a morphogenesis within carcinoma cells referred to as epithelial to mesenchymal transition (EMT)...
  15. Rajvir Dahiya; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Background: Renal cell carcinoma (RCC) is one of the most common malignancies among our Veterans...
  16. Paul J Shami; Fiscal Year: 2014
    ..models of human tumors, JS-K is highly effective against acute myeloid leukemia, prostate cancer, hepatocellular carcinoma, multiple myeloma and non-small cell lung cancer...
  17. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..economic impact, like the inflammatory bowel disease (affecting about 1 person in every 500 in USA), the colon carcinoma (the second most frequent malignancy in developed countries) and numerous infectious diseases...
  18. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..Indeed, loss of heterozygosity at the OGG1 allele was found in human renal clear cell carcinoma (RCC) identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney...
  19. Swati Joshi-Barve; Fiscal Year: 2014
    ..It can be a precursor to cirrhosis, hepatocellular carcinoma and end-stage liver disease...
  20. Susan L Deutscher; Fiscal Year: 2016
    ..Over 28% of cancer diagnoses in US Veterans in 2009 were for prostate, breast, and ovarian carcinoma. However, these cancers are often asymptomatic in beginning stages of the disease...
  21. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..These cell lines that I generate will be cultured with either fibroblasts or ER+ carcinoma cells...
  22. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death and is on the rise in the United States. Preventative strategies are highly important in reducing the incidence and death from HCC...
  23. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  24. Peter Sarnow; Fiscal Year: 2015
    ..the infection and develop chronic infections that often lead to end-stage liver disease and hepatocellular carcinoma. Current treatment is limited to a combination therapy of ribavirin and interferon 1...
  25. ALAN AI PING WEI; Fiscal Year: 2014
    ..They affect 4.5 billion people worldwide and causes up to 150,000 cases of hepatocellular carcinoma each year. In the U.S., mandatory testing is required by the 1990 Farm Bill that stipulates ".....
  26. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..the risk of developing chronic non-alcoholic liver disease, non-alcoholic steatohepatitis, and hepatocellular carcinoma. DM elevates CYP2E1, which is critically important in human health, because it increases oxidative stress, ..
  27. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..that UV-damaged skin has an increased chance of developing one of the forms of skin cancer, including basal cell carcinoma, squamous cell carcinoma and cutaneous malignant melanoma...
  28. Fanyin Meng; Fiscal Year: 2016
    ..alcoholic fatty liver, alcoholic steatohepatitis, alcoholic cirrhosis, and increased risk of hepatocellular carcinoma. The pathological mechanisms of ALD involves complex interactions between the direct effects of alcohol and its ..
  29. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..A 3D culture model of ductal carcinoma in situ will be used to test if altering mechanical or biochemical BM signaling leads to decreased DSB repair in ..
  30. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..HBV leading to nearly one million deaths annually as a result of cirrhosis, liver failure and hepatocellular carcinoma (HCC)...
  31. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..infection with hepatitis B virus and co-exposure to the fungal toxin aflatoxin on human risk for hepatocellular carcinoma, we will purse three aims...
  32. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..Summary/Abstract Tobacco and alcohol use and genetic susceptibility are major risk factors for squamous cell carcinoma of the head and neck (SCCHN)...
  33. Tatiana Efimova; Fiscal Year: 2014
    ..Epithelial cancers, or carcinomas, comprise over 90% of all human cancers. Cutaneous squamous cell carcinoma (SCC) is the second most common cancer in the United States that exhibits poor prognosis in advanced stages...
  34. Zhou Wang; Fiscal Year: 2014
    ..the efficacy of orally administered GL against the incidence, metastasis and burden of PIN and prostate carcinoma using the TRAMP mice model...
  35. Ourania M Andrisani; Fiscal Year: 2015
    ..by applicant): Chronic Hepatitis B Virus (HBV) infection is a major factor in the pathogenesis of hepatocellular carcinoma (HCC)...
  36. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..of initiating biological responses that should prove useful for prevention and/or treatment of hepatocellular carcinoma. We propose to identify SAhRMs by in silico structure-based Virtual Ligand Screening (VLS) coupled with cell- ..
  37. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Head and neck squamous cell carcinoma (HNSCC) is the ninth most common cancer worldwide. In the US there are 40-50,000 new cases a year and ~12,000 deaths due to HNSCC...
  38. Betty L Slagle; Fiscal Year: 2014
    ..350 million people worldwide and is a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC)...
  39. KATHLEEN ELIZABETH COREY; Fiscal Year: 2016
    ..NAFLD affects 30% of Americans and can lead to cirrhosis and hepatocellular carcinoma. More than 12 million Americans are estimated to suffer from OSA which worsens metabolic disease and increases ..
  40. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..by studying hormone and growth factors and their role in the development and pathobiology of squamous cell carcinoma (SCC) in order to support a career in academia and biomedical research. Dr...
  41. SAMUEL WHEELER FRENCH; Fiscal Year: 2015
    ..allow for successful treatment of chronic hepatitis C and reduce the incidence of cirrhosis and hepatocellular carcinoma. PUBLIC HEALTH RELEVANCE: Chronic hepatitis C viral (HCV) infection is the number one causative agent of ..
  42. Vernon K Sondak; Fiscal Year: 2016
    ..Study of the Associations between Cutaneous Papillomavirus and Polyomavirus Infections and Squamous Cell Carcinoma 27 CORE A: Tissue, Pathology and Bioinformatics Core 33 CORE B: Biostatistics Core 36 CORE C: Administration and ..
  43. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..Ids are upregulated in tumor EC isolated from the mouse TRAMP model of prostate carcinoma, suggesting that Ids are pro-angiogenic in vivo in spontaneous tumors...
  44. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..This work will focus on the setting of neoplasia, where lymphatic chemokine-dependent trafficking involves both carcinoma cells as well as immune cells (with focus herein on dendritic cell migration)...
  45. Peter Sarnow; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Approximately 80% of hepatocellular carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  46. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..transgenic models each induce a separate precursor state to advanced bladder cancer: either papillary tumors or carcinoma in situ, as seen in early stages of clinical bladder cancer...
  47. Melinda Sheffield-Moore; Fiscal Year: 2014
    ..will enhance lean muscle mass in patients with advanced (stages IIB, IIIA and IIIB) or recurrent cervical carcinoma by increasing the stimulus for protein synthesis, and by inhibiting the activation of muscle proteolysis, ..
  48. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..The specimen collection includes 80 triple negative, 51 HER2 positive, 26 ER positive, 11 normal and 20 ductal carcinoma in situ (DCIS) samples...
  49. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..In addition, we investigated the transcription profiles in HepG2 cells (a liver carcinoma cell line) with TMPRSS6 overexpression under basal condition and upon stimulation with the potent upregulator of ..
  50. Bachir Taouli; Fiscal Year: 2014
    ..increased risks of liver damage, including fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver transplantation...
  51. CELSO ENRIQUE GOMEZ-SANCHEZ; Fiscal Year: 2016
    ..The H295 cell is a human adrenal carcinoma and responds to aldosterone secretagogues...
  52. SHELLY CHI LOO LU; Fiscal Year: 2016
    ..with chronic hepatic SAMe deficiency have increased oxidative stress, develop steatohepatitis and hepatocellular carcinoma (HCC)...
  53. ALBERT GIROTTI; Fiscal Year: 2015
    ..testing this hypothesis is to study: (i) relative abilities of various established breast, prostate, and skin carcinoma cells to overexpress cytoprotective NOS/NO under ALA/light stress;(ii) mechanisms of NOS induction by ..
  54. Cong Yan; Fiscal Year: 2014
    ..for human lung cancer samples, Stat3 up-regulation was highly associated with adenocarcinoma and squamous cell carcinoma. Therefore, Stat3 and its downstream genes can be used as biomarkers for lung cancer diagnosis in animals and ..
  55. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    ..Originally described in patients with the nevoid basal cell carcinoma syndrome (NBCCS), mutations in sonic hedgehog (shh) signaling genes including patched (ptch), and smoothened (..
  56. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that is treated aggressively when diagnosed at late stages...
  57. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..More than 90% of head and neck malignancies are squamous cell carcinoma (SCC), originating from the epithelium which lines the UADT...
  58. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..provided by applicant): Lymph nodes are the initial sites of metastasis for most solid tumors, including breast carcinoma and melanoma...
  59. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..silencing by promoter DNA methylation is an important mechanism of tumorigenesis, including in hepatocellular carcinoma (HCC)...
  60. Edward A Neuwelt; Fiscal Year: 2015
    ..lung cancer: LX-1 small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) variants H460 large cell carcinoma, H520 squamous cell carcinoma, and A549 adenocarcinoma...
  61. Jinah Choi; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Hepatitis C virus is a major etiologic agent of hepatocellular carcinoma (HCC). HCV-induced HCC is typically preceded by chronic hepatitis and cirrhosis...
  62. Scott W Hiebert; Fiscal Year: 2014
    ..DNA repair and genomic instability, the liver-specific deletion of Hdac3 caused a 100% penetrant hepatocellular carcinoma with a mean time to HCC of 10.2 months...
  63. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..focuses on the role of the loss of function of miR-122 in the development and progression of hepatocellular carcinoma (HCC), one of the most common human malignancies...
  64. Nahid F Mivechi; Fiscal Year: 2016
    ..to determine the impact of Hsf1 deletion in two tumor model systems: (1) a chemically induced hepatocellular carcinoma (HCC) that is a well-established model for chronic inflammation-induced cancer, and (2) a model of spontaneous ..
  65. Luzhe Sun; Fiscal Year: 2016
    ..environmentally relevant doses of BPA in rodents resulted in induction of preneoplastic ductal hyperplasias, carcinoma in situ, and increased susceptibility to tumorigenesis...
  66. Maria Lauda Tomasi; Fiscal Year: 2016
    ..Liver Diseases (ALD) includes simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Sumoylation is a post-translational modification that modulates multiple cellular processes such as signal ..
  67. Robert Harris; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Colorectal carcinoma is the second most common cause of cancer death in the United States with 102,900 new cases in 2010...
  68. Breast Carcinoma in situ: Predicting Risk and Outcomes
    Amy Trentham-Dietz; Fiscal Year: 2013
    ..a consequence of widespread screening mammography, approximately 20% of breast cancer diagnosed today is breast carcinoma in situ (BCIS)...
  69. GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2016
    ..Chronic HBV, complicated by cirrhosis and hepatocellular carcinoma (HCC), is the 10th leading cause of death worldwide. About 7% of Thai adults are HBsAg carriers...
  70. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is now the world's third leading cause of cancer mortality. Alcohol is a well known risk factor for HCC and is suggested to account for 32-45% of all HCC cases...
  71. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    ..Adults with chronic HBV infection acquired in the perinatal period develop hepatocellular carcinoma at a rate of about 5% per decade, approximately 100-fold higher than the rate among uninfected individuals...
  72. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..2009) as well as through up-regulation of ER stress proteins in human renal carcinoma cells (Choi et al., 2011)...
  73. Frank A Anania; Fiscal Year: 2016
    ..Americans will develop liver injury from hepatic fat stores including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC)...
  74. Function of the Ras Related Ral Protein
    LARRY FEIG; Fiscal Year: 2013
    ..In order to understand how Ral GTPases function in squamous carcinoma of the skin, where activated Ras is often an important component, we used a bioengineered tissue model of human ..
  75. Bo Qiu; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy worldwide...
  76. Robert L Ferris; Fiscal Year: 2014
    ..antibody (mAb), cetuximab, is effective therapy only for a subset of advanced head and neck squamous cell carcinoma (HNC). Thus, there is a need to understand why clinical responses vary between individuals...
  77. Yvonne L Kapila; Fiscal Year: 2014
    ..In oral/head and neck squamous cell carcinoma (HNSCC), anoikis resistance induces more aggressive tumors...
  78. Steven P Stratton; Fiscal Year: 2015
    ..More than 1 million cases of non-melanoma skin cancer (NMSC) (basal cell carcinoma [BCC] and squamous cell cancers [SCC]) occur annually...
  79. Jessica Casciano; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and third highest cause of cancer-related deaths...
  80. Ann Richmond; Fiscal Year: 2016
    ..of chemokines/cytokine/ growth factors is often linked to poorer prognosis for women with invasive mammary carcinoma. Chemokines are important for the recruitment of leukocytes to the tumor microenvironment (TME) which can affect ..
  81. Jean Publicover; Fiscal Year: 2016
    ..individuals chronically infected with HBV, 25% will experience liver disease, cirrhosis and hepatocellular carcinoma. Alternatively, 95% of adults infected with HBV experience a self-limiting disease and life-long immunity...
  82. AZADEH POURSAID; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Globally, hepatocellular carcinoma (HCC) of the liver is diagnosed in over 500,000 people annually and trends indicate increasing prevalence...
  83. Jack T Stapleton; Fiscal Year: 2016
    ..C virus (HCV) is an important and worldwide cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. HCV is over-represented among veterans, and the VA medical system provides care for the largest population of ..
  84. ANN CAROL KIMBLE-HILL; Fiscal Year: 2016
    ..Statistically, individuals with hyperplasia are 3-5 times more likely to develop breast cancer, and ductal carcinoma makes up approximately 80% of all breast cancer cases...
  85. Herbert Yu; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is one of the most fatal malignancies in the world. Five-year survival rate of the disease is only 10%. The incidence of HCC has been steadily rising in the US...
  86. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..of these studies is to provide information on the molecular events that contribute to the establishment of colon carcinoma metastasis in the fatty liver that will then lead to more refined targeted therapeutic strategies for the ..
  87. ROSALIND ANNE COLEMAN; Fiscal Year: 2016
    ..Non-alcoholic fatty liver disease is a frequent prelude to fibrosis, cirrhosis and hepatocellular carcinoma, and the presence of TAG droplets in liver is required for replication of viruses like hepatitis C...
  88. John M Essigmann; Fiscal Year: 2015
    ..As a tool, our work focuses on aflatoxin B1 (AFB1), an established risk factor for human hepatocellular carcinoma that strongly elevates risk in synergy with hepatitis B virus infection...
  89. Carol Prives; Fiscal Year: 2015
    ..of p63 isoforms during urothelial development in mice, and determine the expression of p63 isoforms in bladder carcinoma. Cordon-Cardo will also pursue identification of bladder stem cells and the mechanisms by which they are ..
  90. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ..EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS ..
  91. David D Schlaepfer; Fiscal Year: 2016
    ..we showed that blocking the interaction between Rgnef and FAK via a dominant-negative approach inhibited colon carcinoma motility, matrix degradation, and tumor progression...
  92. Lonnie D Shea; Fiscal Year: 2015
    ..with invasive breast cancer, and in 50% estrogen receptor (ER) negative and 12% of ER positive cases of ductal carcinoma in situ...
  93. ROCHELLE LEE TIEDEMANN; Fiscal Year: 2015
    ..The first aim will be accomplished by depleting embryonic carcinoma cells (NCCIT) of the different DNMTs both individually and in a combinatorial fashion via siRNA-mediated ..
  94. RICHARD JASON LAMONTAGNE; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Globally, hepatocellular carcinoma (HCC) is the sixth most common cancer. A lack of early detection methods and effective treatment options also make it one of the most deadly...
  95. Carolyn J Anderson; Fiscal Year: 2014
    ..by applicant): Metastasis to the regional lymph nodes occurs in about 60% of patients with squamous cell carcinoma of the head and neck (SCCHN) [1] and is the most important indicator of disease prognosis and outcome...
  96. Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    Henry Jay Forman; Fiscal Year: 2013
    ..NAC), an antioxidant and glutathione precursor, or by PP2, a Src inhibitor in the human non-small cell lung carcinoma cell line, H358...
  97. TIRUNELVELI RAMALINGAM; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Laryngeal carcinoma is the most common primary head and neck malignancy...
  98. Erin Stashi; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is the most common and highly lethal form of liver cancer, yet the molecular mechanisms underlying HCC pathogenesis remain poorly understood...