pilomatrixoma

Summary

Summary: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)

Top Publications

  1. ncbi Fine-needle aspiration features of pilomatrixoma
    M M Lemos
    Department of Pathology, Gothenburg University Musculoskeletal Tumor Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Cancer 93:252-6. 2001
  2. ncbi Pilomatrixoma: clinicopathologic study of 51 cases with emphasis on cytologic features
    Jun Wang
    Department of Pathology, Harbor UCLA Medical Center, University of California Los Angeles, School of Medicine, Torrance, California, USA
    Diagn Cytopathol 27:167-72. 2002
  3. ncbi Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin
    Henry D Haskell
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cutan Pathol 32:245-50. 2005
  4. ncbi Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma
    Wen Ting Cheng
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Microsc Res Tech 68:75-9. 2005
  5. ncbi Pilomatricoma of the head and neck: a retrospective review of 179 cases
    Ming Ying Lan
    Department of Otolaryngology, Taipei Veterans General Hospital, 201 Shih Pai Road, sector 2, Taipei 112, Taiwan
    Arch Otolaryngol Head Neck Surg 129:1327-30. 2003
  6. ncbi Pilomatrixoma: a review of 346 cases
    Ashkan Pirouzmanesh
    Division of Plastic and Reconstructive Surgery, Children s Hospital, Los Angeles, CA 90027, USA
    Plast Reconstr Surg 112:1784-9. 2003
  7. ncbi Pilomatrixoma of the head and neck
    Chih Chieh Chuang
    Division of Otolaryngology, Taipei Municipal Yang Ming Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:633-6. 2004
  8. ncbi Pilomatrixoma: a potential diagnostic pitfall in aspiration cytology
    S Singh
    Cytopathology 18:260-2. 2007
  9. ncbi Head and neck pilomatrixoma in children
    A Danielson-Cohen
    Department of Otolaryngology--Head and Neck Surgery, University of Illinois Hospital at Chicago, USA
    Arch Otolaryngol Head Neck Surg 127:1481-3. 2001
  10. ncbi Pilomatrixoma: a diagnostic pitfall in fine-needle aspiration biopsies. A review from a small county hospital
    Luciano B Lemos
    Department of Pathology and Surgery Head and Neck, University of Texas Healthcare Center, Houston Medical School, Lyndon B Johnson General Hospital, Houston, TX, USA
    Ann Diagn Pathol 8:130-6. 2004

Research Grants

  1. Lysophosphatidic Acid in Oncogenesis
    Xianjun Fang; Fiscal Year: 2010

Detail Information

Publications176 found, 100 shown here

  1. ncbi Fine-needle aspiration features of pilomatrixoma
    M M Lemos
    Department of Pathology, Gothenburg University Musculoskeletal Tumor Center, Sahlgrenska University Hospital, Gothenburg, Sweden
    Cancer 93:252-6. 2001
    BACKGROUND: Pilomatrixoma (PMX) is a benign skin neoplasm of hair matrix origin. The fine-needle aspiration (FNA) features of PMX frequently lead to a misdiagnosis of carcinoma...
  2. ncbi Pilomatrixoma: clinicopathologic study of 51 cases with emphasis on cytologic features
    Jun Wang
    Department of Pathology, Harbor UCLA Medical Center, University of California Los Angeles, School of Medicine, Torrance, California, USA
    Diagn Cytopathol 27:167-72. 2002
    The clinical and pathologic features of 51 cases of pilomatrixoma found in our archives from 1990-1999 were reviewed, with emphasis on the cytopathologic features of the 22 cases that were sampled by fine-needle aspiration (FNA) biopsy ..
  3. ncbi Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin
    Henry D Haskell
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cutan Pathol 32:245-50. 2005
    ..These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man...
  4. ncbi Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma
    Wen Ting Cheng
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China
    Microsc Res Tech 68:75-9. 2005
    ..applied to analyze the changes in structural conformation and chemical composition of the mass of human skin pilomatrixoma (PMX). The normal skin dermis, collagen type I, and hydroxyapatite (HA) were used as control...
  5. ncbi Pilomatricoma of the head and neck: a retrospective review of 179 cases
    Ming Ying Lan
    Department of Otolaryngology, Taipei Veterans General Hospital, 201 Shih Pai Road, sector 2, Taipei 112, Taiwan
    Arch Otolaryngol Head Neck Surg 129:1327-30. 2003
    To describe the clinical presentations and management of pilomatricoma, formerly known as pilomatrixoma, of the head and neck.
  6. ncbi Pilomatrixoma: a review of 346 cases
    Ashkan Pirouzmanesh
    Division of Plastic and Reconstructive Surgery, Children s Hospital, Los Angeles, CA 90027, USA
    Plast Reconstr Surg 112:1784-9. 2003
    b>Pilomatrixoma, also known as calcifying epithelioma of Malherbe, is a benign skin neoplasm that arises from hair follicle matrix cells...
  7. ncbi Pilomatrixoma of the head and neck
    Chih Chieh Chuang
    Division of Otolaryngology, Taipei Municipal Yang Ming Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:633-6. 2004
    b>Pilomatrixoma is a benign skin appendage tumor that commonly occurs as a solitary lesion and is not usually hereditary...
  8. ncbi Pilomatrixoma: a potential diagnostic pitfall in aspiration cytology
    S Singh
    Cytopathology 18:260-2. 2007
  9. ncbi Head and neck pilomatrixoma in children
    A Danielson-Cohen
    Department of Otolaryngology--Head and Neck Surgery, University of Illinois Hospital at Chicago, USA
    Arch Otolaryngol Head Neck Surg 127:1481-3. 2001
    ..provide a review of the current information on the etiology, clinical presentation, management, and outcome of pilomatrixoma of the head and neck in children. DESIGN: Retrospective review. SETTING: A tertiary care pediatric center...
  10. ncbi Pilomatrixoma: a diagnostic pitfall in fine-needle aspiration biopsies. A review from a small county hospital
    Luciano B Lemos
    Department of Pathology and Surgery Head and Neck, University of Texas Healthcare Center, Houston Medical School, Lyndon B Johnson General Hospital, Houston, TX, USA
    Ann Diagn Pathol 8:130-6. 2004
    ..The FNA smears were reviewed and the diagnosis of a pilomatrixoma (PMT) was reached. The lesion was excised and the diagnosis of benign PMT confirmed...
  11. ncbi Pilomatrixoma as a diagnostic pitfall in fine needle aspiration cytology: a case report
    Sivaselvam Sivakumar
    Department of Pathology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang, Pinang 13200, Malaysia
    Acta Cytol 51:583-5. 2007
    b>Pilomatrixoma (pilomatrixoma, calcifying epithelioma of Malherbe) is a relatively uncommon, benign neoplasm arising from the skin adnexa. The tumor can cause diagnostic difficulty not only for the clinician but also for the cytologist.
  12. ncbi Pilomatrixoma--accuracy of clinical diagnosis
    N Kumaran
    Department of Paediatric Surgery, Yorkhill Royal Hospital for Sick Children, G3 8SJ Glasgow, UK
    J Pediatr Surg 41:1755-8. 2006
    b>Pilomatrixoma is a common tumor of skin appendages in children. The aim of the study was to assess the accuracy of clinical diagnosis and factors contributing to misdiagnosis.
  13. ncbi Malignant pilomatrixoma with multiple local recurrences and distant metastases: a case report and review of the literature
    N G Mikhaeel
    The Meyerstein Institute of Oncology, UCLH, London, UK
    Clin Oncol (R Coll Radiol) 13:386-9. 2001
    Malignant pilomatrixoma is a rare malignant tumour of the hair matrix, which was first described in 1980. Only five patients with distant metastases have been reported...
  14. ncbi Eyelid pilomatricomas in young adults: a report of 8 cases
    Enrique Mencía-Gutiérrez
    Department of Ophthalmology, 12 Octubre Hostpital, Complutense University, Madrid, Spain
    Cutis 69:23-6. 2002
    ..These lesions are frequently misdiagnosed when evaluation is based on clinical evidence alone: only 4 of our cases were correctly diagnosed prior to excisional biopsy...
  15. ncbi Concurrent pilomatrix carcinoma and giant pilomatrixoma
    M R Khammash
    Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    Australas J Dermatol 42:120-3. 2001
    ..of the large thigh lesion showed pilomatrix carcinoma while that of the smaller knee lesion was typical of pilomatrixoma. The pilomatrix carcinoma was widely excised and there has been no evidence of recurrence or metastasis after ..
  16. ncbi Pilomatrixoma breast mimicking carcinoma
    Mujahid Zulfiqar Ali
    Department of Surgery, Mst 5, Mountain Field Ambulance, Azad Kashmir CMH, Hyderabad
    J Coll Physicians Surg Pak 15:248-9. 2005
    ..Histopathology of the resected specimen revealed pilomatrixoma.
  17. ncbi Pilomatrixoma of the face: a benign skin appendage mimicking squamous cell carcinoma
    Ryan M Greene
    Departments of Otolaryngology Head and Neck Surgery and Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Otolaryngol Head Neck Surg 130:483-5. 2004
  18. ncbi Pilomatrixoma in the parotid region
    K K Phyu
    Department of Otolaryngology-Head and Neck Surgery, University Hospital, Queens Medical Centre, Nottingham, UK
    J Laryngol Otol 115:1026-8. 2001
    b>Pilomatrixoma is a benign neoplasm of the hair follicle that may present to the otolaryngologist as a palpable swelling in the head and neck area...
  19. ncbi Giant pilomatrixoma (benign calcifying epithelioma of Malherbe) of the neck and face
    Marijan Kovacic
    Department of Otorhinolaryngology, General Hospital Zadar, Zadar, Croatia
    Dermatol Surg 33:340-3. 2007
  20. ncbi Pilomatrixoma of the ear helix
    Daniel I Nassie
    Department of Otorhinolaryngology and Head and Neck Surgery, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 9:763-4. 2007
  21. ncbi Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst
    Kaoru Kusama
    Department of Oral Pathology, Meikai University School of Dentistry, Saitama, Japan
    Am J Clin Pathol 123:376-81. 2005
    ..raised against human hair proteins and their immunoreactivity was examined in tumors expressing those cells: pilomatrixoma, 14 cases; craniopharyngioma, 17 cases; and calcifying odontogenic cyst (COC), 14 cases...
  22. ncbi Fine-needle aspiration cytology of pilomatrixoma of the arm and the role of cell block examination in the diagnosis
    Raj K Gupta
    Diagn Cytopathol 32:61-2. 2005
  23. ncbi [Pilomatrixoma: ultrasound diagnosis]
    Carolina Whittle
    Servicios de Ecotomografía y Dermatología, Clinica Alemana de Santiago, Hospital Dr Luis Calvo Mackenna, Santiago de Chile
    Rev Med Chil 131:735-40. 2003
    b>Pilomatrixoma is a benign tumor of the skin, preferentially found in children. The final diagnosis is made by biopsy. High resolution ultrasound (US) is a non invasive method for its diagnosis.
  24. ncbi Pilomatrixoma. Review of 205 cases
    Rosa Guinot-Moya
    Barcelona University Dental School, Spain
    Med Oral Patol Oral Cir Bucal 16:e552-5. 2011
    To determine the incidence and clinical features of patients diagnosed with pilomatrixoma.
  25. ncbi Fine needle aspiration cytology of pilomatrixoma and differential diagnoses
    Michelle Dubb
    Cytology Unit, Department of Anatomical Pathology, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa
    Acta Cytol 53:683-8. 2009
    To review the cytologic features of pilomatrixoma to allow a definitive diagnosis at the time of aspiration and correct patient management.
  26. ncbi Aggressive pilomatrixoma of the infra-auricular area: a case report
    Sven Saussez
    Department of Otolaryngology Head and Neck Surgery, CHU Saint Pierre, Universite Libre de Bruxelles, Brussels, Belgium
    Auris Nasus Larynx 32:407-10. 2005
    ..Aggressive pilomatrixoma is a benign tumor of the hair matrix cells affecting mainly children...
  27. ncbi Multiple familial pilomatricomas: a cutaneous marker for Gardner syndrome?
    R M Pujol
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Pediatr Dermatol 12:331-5. 1995
    ..Possibly, multiple familial pilomatricomas could be considered a cutaneous marker of Gardner syndrome...
  28. ncbi Use of ultrasonography in the diagnosis of childhood pilomatrixoma
    J Hughes
    Department of Dermatology, Hillingdon Hospital, Uxbridge, Middlesex, United Kingdom
    Pediatr Dermatol 16:341-4. 1999
    ..In the majority of patients, sonography either correctly supported or excluded the clinical diagnosis of pilomatrixoma and contributed to appropriate preoperative assessment and subsequent management of the lesion...
  29. ncbi Multiple pilomatricomas: cutaneous marker for myotonic dystrophy
    Quyn J Sherrod
    Dermatol Online J 14:22. 2008
    ..The resulting gene product activates transcription leading to tumorigenesis [1]. Since the onset of MPs may precede the signs of myotonic dystrophy, they can serve as potential early cutaneous markers for this systemic disease...
  30. ncbi Clinicopathological study of pilomatricoma
    A H Darwish
    Department of Pathology and Surgery, BDF Hospital, Bahrain
    Saudi Med J 22:268-71. 2001
    ..They should be considered along with other benign and malignant conditions in the clinical differential diagnosis of solitary firm skin nodules especially those, which occur in the head, neck and upper limb...
  31. ncbi Pilomatrixoma in an infant: diagnostic challenges of fine-needle aspiration
    Kanyalakshmi Ayyanar
    Department of Pediatric Hematology Oncology, University of Louisville, Kosair Children s Hospital, Louisville, KY 40202, USA
    J Pediatr Hematol Oncol 30:625-7. 2008
    ....
  32. ncbi A case of perforating pilomatricoma
    Harun Ciralik
    Department of Pathology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey
    J Dermatol 33:394-8. 2006
    ..If total excision is not the method of choice, multiple punch biopsies should be made from different areas in large skin tumors for correct diagnosis...
  33. ncbi Perforating pilomatricoma on the upper eyelid
    Katsunori Niitsuma
    Division of Plastic Surgery, Nara Medical University, Kashihara, Japan
    J Craniofac Surg 17:372-3. 2006
    ..These findings are consistent with the diagnosis of perforating pilomatricoma...
  34. ncbi Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and β-catenin
    D Krahl
    Institut für Dermatohistologie, Heidelberg, Germany
    Br J Dermatol 162:1294-301. 2010
    ....
  35. ncbi beta-Catenin expression in the transitional cell zone of pilomatricoma
    S W Park
    Department of Dermatology, Pusan Paik Foundation Hospital, Inje University Medical College, 633 165 Kaekum Dong, Pusanjin Ku, Pusan 614 735, Korea
    Br J Dermatol 145:624-9. 2001
    ..However, the pattern of beta-catenin expression in pilomatricoma tissues is still unclear. Objectives To examine the expression of beta-catenin in human pilomatricomas by immunohistochemical staining...
  36. ncbi Multiple pilomatricomas in Rubinstein-Taybi syndrome: a case report
    S Cambiaghi
    1st Dept. of Dermatology and Pediatric Dermatology, IRCCS-University of Milan, Italy
    Pediatr Dermatol 11:21-5. 1994
    ..Possibilities to explain the association include contiguous gene syndrome, the action of a pleiotropic gene, predisposition to malformations, and mere coincidence...
  37. ncbi [Pilomatrix carcinoma: histologic and immunohistochemical features. Two studies]
    Thomas Petit
    Service d Anatomie Pathologique, Hopital Bichat Claude Bernard, Paris
    Ann Pathol 23:50-4. 2003
    ..No feature is specific to confirm wether a malignant pilomatricoma arises de novo, or whether it is a malignant transformation of a pre-existing benign pilomatricoma...
  38. ncbi Pilomatrixoma of the head and neck in children
    R P Agarwal
    Division of Pediatric Otolaryngology and Department of Pathology, The Children's Hospital of Philadelphia, PA 19104, USA
    Otolaryngol Head Neck Surg 125:510-5. 2001
    ..STUDY DESIGN: A retrospective chart review was performed of all patients with histologically confirmed pilomatrixoma of the head and neck excised during a 6-year period (1992-1997) at the Children's Hospital of Philadelphia...
  39. ncbi A 12-year-old girl with an enlarging nontender nodule on the arm
    Annette M Wagner
    Children s Memorial Medical Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Pediatr Ann 35:445-7. 2006
  40. ncbi Pilomatricomas in children: imaging characteristics with pathologic correlation
    Hyun Wook Lim
    Department of Radiology, Kangnam St Mary s Hospital, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Pediatr Radiol 37:549-55. 2007
    ..Although pilomatricoma commonly occurs in children, there is still a poor understanding of the imaging characteristics of pilomatricoma and lack of agreement regarding its imaging findings and histopathologic features...
  41. ncbi Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins
    K Kizawa
    Basic Research Laboratory, Kanebo Cosmetics Inc, Kotobuki cho, Odawara, Japan
    Br J Dermatol 152:314-20. 2005
    b>Pilomatrixoma is a common benign cutaneous tumour containing differentiated hair matrix cells. This tumour is mainly composed of basophilic, transitional, shadow and squamoid cells...
  42. ncbi Cytokeratin profile in basal cell carcinoma
    Elvio Alessi
    Institute of Dermatological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Am J Dermatopathol 30:249-55. 2008
    ..No significant difference in the CK profile among the BCC subtypes studied was found...
  43. ncbi Expression of CD10 in basal cell carcinoma
    Kazuhiro Yada
    Department of Pathology, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Am J Dermatopathol 26:463-71. 2004
    ..CD10 might be an indicator of tumor invasiveness if it is expressed in stromal cells, while it might be a marker of follicular differentiation if it is expressed in the actual tumor cells of cutaneous epithelial neoplasms...
  44. ncbi Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin
    Alexander J F Lazar
    Department of Pathology, Division of Dermatopathology, Brigham and Women s Hospital, Boston, MA, USA
    J Cutan Pathol 32:148-57. 2005
    ..This implies a common initial pathogenesis and is compatible with the proposition that pilomatrix carcinomas may at least on occasion arise from their benign counterparts...
  45. ncbi Giant pilomatricoma
    Gian Piero Lozzi
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    Am J Dermatopathol 29:286-9. 2007
    ..Our report highlights an unusual clinical appearance of pilomatricoma that made us consider a variety of primary or secondary cutaneous neoplasms in its differential diagnosis...
  46. ncbi Multiple giant pilomatricoma in familial Sotos syndrome
    Yolanda Gilaberte
    Department of Dermatology, Hospital San Jorge, Huesca, Spain
    Pediatr Dermatol 25:122-5. 2008
    ..We report a 9-year-old boy, diagnosed with familial Sotos syndrome, who had two pilomatrixoma, symmetrically located on both sides of the neck, measuring 4 cm in diameter...
  47. ncbi Nanobacteria and calcinosis cutis
    Michael B Morgan
    Department of Pathology, James Haley Veteran s Hospital, and University of South Florida College of Medicine, Tampa, FL, USA
    J Cutan Pathol 29:173-5. 2002
    ..The pathogenesis of calcinosis cutis and its significance in conjunction with a variety of unrelated scarring and pre-existing cutaneous entities are incompletely understood...
  48. ncbi Multinodular pilomatrixoma
    Raquel S Simon
    Department of Dermatology, Investigation Unit of the Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Dermatology 204:80-1. 2002
    ..showed a multinodular cyst-like proliferation, each nodule showing the typical structure and cytology of pilomatrixoma. A comparison is made between this case and the budding phenomenon that has been described in isthmus-catagen (..
  49. ncbi Multiple pilomatricomas in association with spina bifida
    Josie Amley Pielop
    Pediatr Dermatol 22:178-9. 2005
  50. ncbi Papillary endothelial hyperplasia and dilated lymphatic vessels in bullous pilomatricoma
    Li Min Lao
    Departments of Dermatology, Affiliated Second Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Acta Derm Venereol 85:160-3. 2005
    ..Abundant fibrous long-spacing collagen was observed in the connective tissue and fibroblasts within papillae...
  51. ncbi Pilomatricoma mimicking small round cell tumor on fine needle aspiration cytology: a case report
    Naveen Thapliyal
    Department of Pathology, Uttaranchal Forest Hospital Trust Medical College, Haldwani, Uttaranchal, India
    Acta Cytol 52:627-30. 2008
    ..We report a rapidly growing nodular swelling misdiagnosed as round cell tumor cytologically and found to be pilomatricoma histopathologically...
  52. ncbi Pilomatricoma in a pediatric patient
    Adam F Gustin
    Department of Radiology, Mount Auburn Hospital, Cambridge, MA, USA
    Pediatr Radiol 36:1113. 2006
  53. ncbi [Pilomatrixoma of the head and neck in six cases]
    Erdogan Okur
    Department of Otolaryngology, Medicine Faculty of Kahramanmaraş Sütçü Imam University, Kahramanmaras, Turkey
    Kulak Burun Bogaz Ihtis Derg 14:121-6. 2005
    ..We present six patients (age range 6 to 68 years) with pilomatrixoma in the head and neck region...
  54. ncbi Simultaneous multiple pilomatrixomas
    Gulden Avci
    Department of Plastic and Reconstructive Surgery Dr Lütfi Kirdar Kartal Education and Research Hospital Istanbul, Turkey
    Pediatr Dermatol 23:157-62. 2006
    ..Concurrent disorders were not identified in our patient and the etiology of her pilomatrixomas was not understood. Thorough examination of the patient and long-term follow-up are necessary with these tumors...
  55. ncbi Pilomatrix carcinoma: case report and review of literature
    R Dutta
    Department of Tissue Pathology, ICPMR, Westmead Hospital, Sydney, Australia
    Pathology 33:248-51. 2001
    ..Pilomatrix carcinoma is the rare malignant counterpart of pilomatrixoma. It has a potential for local recurrence and can metastasise to distant sites...
  56. ncbi Follicular germinative cells in pilomatricoma
    Wataru Nishie
    Department of Dermatology, Kin ikyo Central Hospital, Sapporo, Japan
    Am J Dermatopathol 28:510-3. 2006
    ....
  57. ncbi The common ultrasonographic features of pilomatricoma
    Ji Young Hwang
    Department of Radiology and Medical Research Institute, Ewha Womans University College of Medicine, 911 1 MokDong, Yangcheongu, 158 710 Seoul, Korea
    J Ultrasound Med 24:1397-402. 2005
    ..The purpose of this series was to describe typical ultrasonographic features of 20 cases of pilomatricoma and to improve its diagnostic rate with the use of an ultrasonographic approach...
  58. ncbi Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors
    Nese Calli Demirkan
    Department of Pathology, Medical School of Pamukkale University, Denizli, Turkey
    J Cutan Pathol 34:467-73. 2007
    ..Sublocation of beta-catenin has been demonstrated by immunohistochemistry. The aim of this study was to determine the role of beta-catenin-related proteins in various benign trichogenic tumors...
  59. ncbi Pilomatricoma arising at a BCG vaccination site
    S Aquilina
    Clin Exp Dermatol 31:296-7. 2006
  60. ncbi On the regulation of hair keratin expression: lessons from studies in pilomatricomas
    Bernard Cribier
    Clinique Dermatologique, Hopital Civil, Strasbourg, France
    J Invest Dermatol 122:1078-83. 2004
    ..These data imply that unlike the normal hair follicle, cortical differentiation in pilomatricomas is not under the control of the canonical Wnt signaling pathway...
  61. ncbi [Benign hair-follicle derived eyelids tumors in adults]
    E Mencía Gutiérrez
    Hospital 12 de Octubre, Universidad Complutense, Madrid, Espana
    Arch Soc Esp Oftalmol 77:605-10. 2002
    ..Benign eyelid neoplasms derived from hair follicles are frequently misdiagnosed, including pilomatricoma, trichoepithelioma, trichilemmoma, trichoblastoma and inverted follicular keratosis...
  62. ncbi A tumor with composite pilo-folliculosebaceous differentiation harboring a recently described new entity--melanocytic matricoma
    Clara Rizzardi
    Unit of Pathology, University of Trieste, Italy
    Am J Dermatopathol 24:493-7. 2002
    ..We believe that sunlight may have played a role in the development of this peculiar neoplasm...
  63. ncbi Pilomatrixoma of the retroauricular area and arm
    L Migirov
    Department of Otolaryngology Head and Neck Surgery, Sheba Medical Center, Tel Hashomer, Israel
    J Pediatr Surg 37:E20. 2002
    b>Pilomatrixoma is a benign tumor of hair follicles that usually occurs as a single tumor and appears in the head and neck region, extremities, and trunk. The authors present a case of pilomatrixoma with multifocal localization...
  64. ncbi Secondary anetoderma overlying pilomatrixomas
    Masaki Fujioka
    Department of Plastic and Reconstructive Surgery, Fukuoka Tokushukai Medical Center, Fukuoka, Japan
    Dermatology 207:316-8. 2003
    ..Both phenomena may be caused by continuous pressure from the outside, as these anetodermic pilomatrixomas were located where they were apt to be exposed to mechanical irritation...
  65. ncbi beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst
    Ashraf M Hassanein
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, PO Box 100275, Gainesville, FL 32610, USA
    Am J Clin Pathol 120:732-6. 2003
    ..The latter could be related to their shared method of keratinization or shared dysfunction of the cellular adhesion complex leading to tumorigenesis...
  66. ncbi A benign pilomatrixoma mimicking a skull vault tumour in a 9-month-old girl
    J J Fitzgerald
    Department of Neurosurgery, University Hospital Nottingham, Queens Medical Centre, UK
    Br J Neurosurg 17:469-70. 2003
  67. ncbi Multiple familial pilomatrixomas
    T Karpuzoglu
    J Eur Acad Dermatol Venereol 17:358-9. 2003
  68. ncbi Melanocytic matricoma: case confirmation of a recently described entity
    Christy M Williams
    Department of Pathology, University of South Alabama, Mobile, Alabama, USA
    J Cutan Pathol 30:275-8. 2003
    ..In 1999, Carlson et al. reported two cases of a matrical neoplasm that recapitulates the bulb of the anagen hair follicle, which they designated as melanocytic matricoma...
  69. ncbi [Clinicopathologic study of eyelid pilomatrixoma: the experience of the "Hospital Universitário Prof. Edgard Santos"]
    Eduardo Ferrari Marback
    Hospital Universitario, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brasil
    Arq Bras Oftalmol 70:501-3. 2007
    To report the experience with eyelid pilomatrixoma during 30 years in a university hospital.
  70. ncbi Fine needle aspiration cytology of pilomatricoma in three dogs
    Carlo Masserdotti
    Clinica Veterinaria S Antonio, via Montale n degrees 2, 25087 Salo BS Italy
    Vet Clin Pathol 31:22-5. 2002
    ..Fine needle aspiration cytology is being used for the diagnosis of various neoplasms, but we are unaware of reports dealing with the cytologic features of canine pilomatricoma...
  71. ncbi [Case of Malherbe's epithelioma and lymphocytoma of the eyelid skin]
    A F Gabdrakhmanova
    Vestn Oftalmol 119:42-3. 2003
  72. ncbi Pilomatrix carcinoma with lymph node metastases
    Assia Bassarova
    Department of Pathology, Alexander University Hospital, Medical University, Sofia, Bulgaria
    J Cutan Pathol 31:330-5. 2004
    ....
  73. ncbi Beta-catenin expression in benign and malignant pilomatrix neoplasms
    A M Hassanein
    Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA
    Br J Dermatol 150:511-6. 2004
    ..Exon 3 beta-catenin-activating mutations were found in 75% of cases of pilomatricoma (PM). Previous studies have shown that nuclear and/or cytoplasmic staining may correlate with beta-catenin gene mutation...
  74. ncbi Pilomatrixoma: never lower your guard
    José García Solano
    Diagn Cytopathol 35:457-8. 2007
  75. ncbi Bone morphogenetic protein-mediated type II collagen expression in pilomatricoma and cutaneous mixed tumor
    Hideki Mieno
    Department of Dermatology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Cutan Pathol 32:206-11. 2005
    ..We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma...
  76. pmc Differential expression of cyclin D1 in the human hair follicle
    Xiaowei Xu
    Department of Pathology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 163:969-78. 2003
    ..Our data also demonstrate that the combination of DNA macroarray, LCM and quantitative real-time PCR is a powerful approach for the study of gene expression in defined cell populations with limited starting material...
  77. ncbi Idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases
    F Boralevi
    Laboratory of Pathology, Hôpital Pellegrin enfant, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Br J Dermatol 156:705-8. 2007
    ..Idiopathic facial aseptic granuloma (IFAG) was recently described in a single-centre retrospective study as a skin condition that occurs specifically in childhood...
  78. ncbi Nasal hair matrix cyst mimicking dermoid cyst
    Oguz Kayiran
    1st Plastic and Reconstructive Surgery Clinic, Ankara Research and Training Hospital, Ankara, Turkey
    J Craniofac Surg 19:1422-4. 2008
    ..Hair matrix cyst is a variant of epidermal cyst resembling the pattern of pilomatrixoma. Formerly, nasal hair matrix cyst has not been reported at all...
  79. ncbi Non-melanocytic benign skin tumors in children
    Ana Lucas
    Department of Dermatology, Hospital General Universitario de Alicante, Alicante, Spain
    Am J Clin Dermatol 8:365-9. 2007
    ..Dermatologists often attend children with benign skin tumors and cysts. The decision to perform dermatologic surgery in children may be difficult to make, especially in cases of benign tumors...
  80. ncbi [Mature cystic teratoma of the testis (dermoid cyst). Case report and literature review]
    P Garrido Abad
    Servicio de Urología y Servicio de Anatomía Patológica1, Hospital del Henares, Coslada Madrid, Espana
    Arch Esp Urol 62:747-51. 2009
    ..Case report of a mature cystic teratoma (dermoid cyst), pseudopilomatrixoma like variant...
  81. ncbi [Subcutaneous tumour in an adolescent]
    M C Herwig
    Universitäts Augenklinik Bonn, Bonn
    Ophthalmologe 107:668-71. 2010
    ..Clinically suspicious for dermoid cyst or pilomatrixoma, it was decided to remove the tumour completely...
  82. pmc Pilomatrixoma of earlobe
    Mohamed Jallouli
    Department of Pediatric Surgery, Hedi Chaker Hospital, Sfax, Tunisia
    J Cutan Aesthet Surg 2:36-7. 2009
    ..The lesion was treated by simple enucleation and in two years of follow-up there has been no evidence of recurrence. The case is being reported in view of its rarity and unusual location...
  83. ncbi Keratinous cyst of the palpebral conjunctiva
    Frederick A Jakobiec
    David G Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Ophthal Plast Reconstr Surg 25:337-9. 2009
    ..a unique keratinous cyst was delimited mostly by basaloid cells resembling the matrical cells in pilomatrixoma. There were no keratohyalin granules in the lining cells, which focally transformed in ghost cells...
  84. ncbi Subepidermal calcified nodule in children: a clinicopathologic study of 21 cases
    M J Evans
    Department of Pathology, Aberdeen University, Foresterhill, Scotland
    Pediatr Dermatol 12:307-10. 1995
    ..There was no evidence of pilomatrixoma or pre-existing nevus...
  85. ncbi Pilomatricoma: a dermal analog of calcifying odontogenic cyst
    H Kaveri
    Department of Oral Pathology and Microbiology, SDM College of Dental Sciences, Dharwad 580 009, Karnataka, India
    Indian J Dent Res 19:261-3. 2008
    ..Here, we describe a case of pilomatricoma of the periorbital region in a young Indian female patient. We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions...
  86. ncbi Giant pilomatricoma associated with hypercalcaemia and elevated levels of parathyroid hormone-related protein
    Y Kambe
    Br J Dermatol 155:208-10. 2006
  87. ncbi Characteristics of pilomatrixoma in children: a review of 137 patients
    Daniel Kwon
    Department of Otolaryngology Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA Electronic address
    Int J Pediatr Otorhinolaryngol 78:1337-41. 2014
    To describe our institutional experience with pilomatrixoma in the pediatric population, specifically examining its clinical presentation, associated conditions, surgical treatment and future implications.
  88. ncbi Melanocytic matricoma: a distinctive clinicopathologic entity
    Mohammed N Islam
    Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, University of Florida, Gainsville, FL, USA
    Dermatol Surg 33:857-63. 2007
  89. ncbi A rare presentation of giant pilomatricoma located on the back
    Fatih Goktay
    Department of Dermatology, Haydarpasa Numune Training and Research Hospital, 34668 Uskudar, Istanbul, Turkey
    Dermatol Surg 33:596-600. 2007
  90. ncbi A histopathological study of ophthalmic lesions
    S Pudasaini
    Department of Pathology, Nepal Medical College Teaching Hospital, Jorpati, Kathmandu, Nepal
    Nepal Med Coll J 15:78-80. 2013
    ..Other lesions like inclusion cyst, dermoid cyst, seborrheic keratosis, pilomatrixoma, nevus and molluscum contagiosum are also included in our study.
  91. ncbi Molecular pathology of skin neoplasms of the head and neck
    Stefan Kraft
    From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Dr Kraft and the Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts Dr Granter
    Arch Pathol Lab Med 138:759-87. 2014
    ..Skin neoplasms include the most common malignancies affecting humans. Many show an ultraviolet (UV)-induced pathogenesis and often affect the head and neck region...
  92. ncbi [An unusual presentation of a pilomatrixoma in the eyelid]
    C Izquierdo-Rodríguez
    Hospital 12 de Octubre, Universidad Complutense, Madrid, Espana
    Arch Soc Esp Oftalmol 81:483-6. 2006
    ..The presumed diagnosis was a pyogenic granuloma. An excision biopsy was performed and the histopathologic diagnosis was a pilomatrixoma.
  93. ncbi Pilomatrix carcinoma: a case report and review of the literature
    Kristine M Cornejo
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Dermatopathol 35:389-94. 2013
    b>Pilomatrixoma is a common benign neoplasm of children and young adults with a female predilection. In contrast, its malignant counterpart, pilomatrix carcinoma is a rare neoplasm of older adults with a male preponderance...
  94. ncbi Multiple perforating and non perforating pilomatricomas in a patient with Churg-Strauss syndrome and Rubinstein-Taybi syndrome
    P Bayle
    Services de Dermatologie, Place du Dr Baylac, Toulouse Cedex, France
    J Eur Acad Dermatol Venereol 18:607-10. 2004
    ..These syndromes may be independent, but these rare diseases and genetic abnormalities may be linked together...
  95. ncbi Multiple pilomatricoma in trisomy 9
    H Matsuura
    Dermatology 204:82-3. 2002
  96. ncbi Basaloid tumors of the salivary glands
    David C Chhieng
    Department of Pathology, University of Alabama at Birmingham, AL 35249 6823, USA
    Ann Diagn Pathol 6:364-72. 2002
    ..However, in limited biopsies and particularly in cytologic samples, the evaluation can be quite challenging. A systematic approach aided by immunohistochemistry is essential to arrive at an accurate diagnosis...
  97. ncbi [Adnexal skin tumors, gigantic dimensions]
    E Halbach
    Klinikum Lüdenscheid, Klinik für Plastische, Hand und Gesichtschirurgie
    Handchir Mikrochir Plast Chir 44:375-8. 2012
    ..Adnexal skin tumors are rare and mostly not common. Their appearance are atypical and only histologically to save. 2 cases were demonstrated with impressing extension demanding a complex surgical approach...
  98. ncbi Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study
    Bernard Cribier
    Department of Dermatology, University Hospital, Strasbourg, France
    J Cutan Pathol 33:1-9. 2006
    ..In contrast, hHa1 expression in the upper transitional cell compartment is uncoupled from the nuclear co-expression of the LEF1/beta-catenin complex seen in normal hair follicles (Cribier et al., J Invest Dermatol 2004; 122: 1078)...
  99. ncbi [Anetodermal pilomatricoma]
    B Monteagudo Sánchez
    An Pediatr (Barc) 64:181-2. 2006
  100. ncbi Isotretinoin in the treatment of multiple benign pilomatrixomas in a mixed-breed dog
    Stefano Toma
    Ospedale Veterinario Cuneese, Via Cuneo 52 N, 12011 Borgo S Dalmazzo CN, Italy
    Vet Dermatol 16:346-50. 2005
    ..No adverse effects were noted. To the authors' knowledge, this is the first report of multiple pilomatrixomas arising in a young dog and successfully controlled with oral retinoids...
  101. ncbi Pilomatrix carcinoma of the clitoris
    Barbara Gazic
    Institute of Oncology, Ljubljana, Slovenia
    Int J Surg Pathol 19:827-30. 2011
    Pilomatrix carcinoma, a malignant counterpart of pilomatrixoma, is a rare skin neoplasm composed of basaloid and shadow cells that characterize differentiation toward the hair matrix...

Research Grants1

  1. Lysophosphatidic Acid in Oncogenesis
    Xianjun Fang; Fiscal Year: 2010
    ..tumors include malignant lymphoma, lung adenocarcinoma, high-grade sarcoma, leiomyosarcoma, plasmacytoma and pilomatrixoma. The wide spectrum of tumors found in these mice not only provides direct evidence for aberrant LPA signaling ..