lobular carcinoma

Summary

Summary: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)

Top Publications

  1. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
  2. pmc Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
    Hongjuan Zhao
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 15:2523-36. 2004
  3. ncbi Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer
    Wendie A Berg
    American College of Radiology Imaging Network, 301 Merrie Hunt Drive, Lutherville, MD 21093, USA
    Radiology 233:830-49. 2004
  4. ncbi Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer
    T Kuukasjärvi
    Department of Pathology, Tampere University Hospital, University of Tampere, Finland
    Cancer Res 57:1597-604. 1997
  5. pmc E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
    G Berx
    Laboratory of Molecular Biology, University of Ghent, Belgium
    EMBO J 14:6107-15. 1995
  6. ncbi Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Breast Cancer Res Treat 113:59-66. 2009
  7. ncbi Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival
    L Nakopoulou
    Department of Pathology, Medical School University of Athens, Athens, Greece
    Histopathology 40:536-46. 2002
  8. ncbi Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:620-7. 2002
  9. ncbi Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes
    Lenora W M Loo
    Division of Human Biology, Division of Public Health Sciences, and Genomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:8541-9. 2004
  10. ncbi Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006

Detail Information

Publications284 found, 100 shown here

  1. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..In human breast cancers, high level of Twist expression is correlated with invasive lobular carcinoma, a highly infiltrating tumor type associated with loss of E-cadherin expression...
  2. pmc Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
    Hongjuan Zhao
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 15:2523-36. 2004
    Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological types of breast cancer worldwide...
  3. ncbi Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer
    Wendie A Berg
    American College of Radiology Imaging Network, 301 Merrie Hunt Drive, Lutherville, MD 21093, USA
    Radiology 233:830-49. 2004
    ..To prospectively assess accuracy of mammography, clinical examination, ultrasonography (US), and magnetic resonance (MR) imaging in preoperative assessment of local extent of breast cancer...
  4. ncbi Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer
    T Kuukasjärvi
    Department of Pathology, Tampere University Hospital, University of Tampere, Finland
    Cancer Res 57:1597-604. 1997
    ....
  5. pmc E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
    G Berx
    Laboratory of Molecular Biology, University of Ghent, Belgium
    EMBO J 14:6107-15. 1995
    ..These findings offer a molecular explanation for the typical scattered tumour cell growth in infiltrative lobular breast cancer...
  6. ncbi Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Breast Cancer Res Treat 113:59-66. 2009
    Loss of the chromosomal material at 16q is the most frequent genetic event in invasive and in situ (LCIS) lobular carcinoma of the breast...
  7. ncbi Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival
    L Nakopoulou
    Department of Pathology, Medical School University of Athens, Athens, Greece
    Histopathology 40:536-46. 2002
    ....
  8. ncbi Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:620-7. 2002
    ..This group needs further evaluation for better understanding of its significance, pattern of progression, and behavior...
  9. ncbi Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes
    Lenora W M Loo
    Division of Human Biology, Division of Public Health Sciences, and Genomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:8541-9. 2004
    ..infiltrating ductal carcinoma, ER-positive infiltrating ductal carcinoma, and ER-positive infiltrating lobular carcinoma. We observed a consistent association between loss in regions of 5q and ER-negative infiltrating ductal ..
  10. ncbi Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006
    ....
  11. pmc A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH
    R Roylance
    Molecular and Population Genetics Laboratory, Cancer Research UK, Lincoln s Inn Fields, London, UK
    Oncogene 25:6544-53. 2006
    ..Higher-grade IDCs probably develop from low-grade lesions in most cases, but there remains evidence that some GII/GIII IDCs arise without a GI precursor...
  12. ncbi Response to neoadjuvant chemotherapy in lobular and ductal breast carcinomas: a retrospective study on 860 patients from one institution
    M Tubiana-Hulin
    Department of Medical Oncology, Centre Rene Huguenin, Saint Cloud, France
    Ann Oncol 17:1228-33. 2006
    ..We compared the impact of neoadjuvant chemotherapy on pathologic response and outcome in operable invasive lobular breast carcinoma (ILC) and invasive ductal breast carcinoma (IDC)...
  13. ncbi Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 289:3254-63. 2003
    ..Women using combined estrogen and progestin hormone replacement therapy (CHRT) have an increased risk of breast cancer; however, data on use for long durations and on risk associated with patterns of use are lacking...
  14. ncbi Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Cancer 100:2562-72. 2004
    b>Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts...
  15. ncbi The Yale University experience of early-stage invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) treated with breast conservation treatment (BCT): analysis of clinical-pathologic features, long-term outcomes, and molecular expression of
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Breast J 15:571-8. 2009
    ..Future investigations of chemo-preventive strategies to decrease contralateral breast cancers are warranted...
  16. ncbi Identifying patients at risk of compromised margins following breast conservation for lobular carcinoma
    Mary F Dillon
    Department of Surgery, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Am J Surg 191:201-5. 2006
    The association of invasive lobular carcinoma with high rates of compromised margins in breast conservation makes choice of operation for these patients difficult...
  17. ncbi PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma
    Fiamma Buttitta
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    J Pathol 208:350-5. 2006
    ....
  18. ncbi Molecular cytogenetics of primary breast cancer by CGH
    M Tirkkonen
    Laboratory of Cancer Genetics, University and University Hospital, Tampere, Finland
    Genes Chromosomes Cancer 21:177-84. 1998
    ..Further studies of such common changes may form the basis for a molecular cytogenetic classification of breast cancer...
  19. ncbi Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer
    Andreas Widschwendter
    Department of Obstetrics and Gynecology and Institute of Medical Chemistry and Biochemistry University of Innsbruck, A 6020 Innsbruck, Austria
    Clin Cancer Res 8:3065-74. 2002
    ..The predictive value of STAT activation on relapse-free and overall survival among women who received treatment for primary breast cancer was evaluated in a retrospective study...
  20. ncbi Localized amyloidosis of the breast associated with invasive lobular carcinoma
    J M Sabate
    Unit of Breast Imaging, Department of Diagnostic Radiology, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, Barcelona 08025, Spain
    Br J Radiol 81:e252-4. 2008
    Here a case of primary amyloidosis of the breast associated with invasive lobular carcinoma is reported with a brief review of the most relevant clinical, radiological and pathological features...
  21. ncbi Expression of CD44 isoforms in infiltrating lobular carcinoma of the breast
    H S Berner
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello
    Breast Cancer Res Treat 65:23-9. 2001
    ..048). In classical, classical/trabecular and trabecular carcinomas expression of membranous CD44s was significantly correlated with lymph node status (P = 0.042)...
  22. ncbi Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
    Andrew G Glass
    Oncology Research, Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    J Natl Cancer Inst 99:1152-61. 2007
    ..We examined the potential association between menopausal hormone therapy use and recent changes in breast cancer incidence...
  23. ncbi Biologic markers in axillary node-negative breast cancer: differential expression in invasive ductal carcinoma versus invasive lobular carcinoma
    Ana Maria Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 7:396-400. 2006
    ..expression of established histopathologic and biologic markers of proliferation, apoptosis, and angiogenesis in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) in a group of axillary node-negative breast cancers.
  24. ncbi Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences and Nottingham University Hospitals Trust, University of Nottingham, Nottingham, UK
    Am J Surg Pathol 32:513-23. 2008
    ..Our findings support the concept that progression of LNGBC to HNGBC (basal-like or HER2+) phenotype is an unlikely biologic phenomenon...
  25. pmc Association of infiltrating lobular carcinoma with positive surgical margins after breast-conservation therapy
    M M Moore
    Division of Surgical Oncology, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0709, USA
    Ann Surg 231:877-82. 2000
    To determine whether infiltrating lobular carcinoma (ILC) is associated with high positive-margin rates for single-stage lumpectomy procedures, and to define clinical, mammographic, or histologic characteristics of ILC that might ..
  26. ncbi Locally advanced breast cancer: comparison of mammography, sonography and MR imaging in evaluation of residual disease in women receiving neoadjuvant chemotherapy
    Viviana Londero
    Institute of Radiology, University of Udine, Via Colugna 50, 33100 Udine, Italy
    Eur Radiol 14:1371-9. 2004
    ..false-negative results because of the presence of microfoci of in situ ductal carcinoma (DCIS) and invasive lobular carcinoma (LCI). MRI was superior to mammography in cases of multifocal or multicentric disease (83 vs. 33%)...
  27. ncbi Invasive lobular carcinoma: to grade or not to grade
    Anita L Bane
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Mod Pathol 18:621-8. 2005
    ..The purpose of this study was to correlate histologic grade in invasive lobular carcinoma with known prognostic and predictive markers...
  28. ncbi Molecular classification system identifies invasive breast carcinoma patients who are most likely and those who are least likely to achieve a complete pathologic response after neoadjuvant chemotherapy
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Cancer 110:1687-96. 2007
    ..In the current study, the authors evaluated whether response to neoadjuvant chemotherapy was correlated with the molecular classification groups...
  29. ncbi A comparison of ink-directed and traditional whole-cavity re-excision for breast lumpectomy specimens with positive margins
    G R Gibson
    Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Surg Oncol 8:693-704. 2001
    ....
  30. ncbi Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988-2001
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Epidemiology Program, Seattle, Washington, USA
    Cancer 106:2104-12. 2006
    Incidence rates of ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) have been rising, but little is known about which patients will develop invasive breast cancer or what types of tumors these patients may develop.
  31. pmc Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation
    G Keller
    Institute of Pathology, Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Am J Pathol 155:337-42. 1999
    ..Thus, our finding suggests that besides diffuse type gastric cancer, lobular breast carcinomas may be associated with germline CDH1 mutations...
  32. ncbi E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma
    Amer Wahed
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
    Ann Diagn Pathol 6:349-51. 2002
    Pleomorphic lobular carcinoma is a recently described entity separated from classical lobular carcinoma by cytologic pleomorphism. It can have an aggressive clinical course with a higher frequency of recurrence...
  33. ncbi Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    Patrick W B Derksen
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 10:437-49. 2006
    ..Loss of E-cadherin is associated with tumor metastasis, as well as with invasive lobular carcinoma (ILC), which accounts for 10%-15% of all breast cancers...
  34. ncbi Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    J Pathol 214:17-24. 2008
    ..8). In conclusion, this study demonstrates that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development...
  35. pmc Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    BMC Cancer 7:55. 2007
    ..The aim of our study was to identify gene expression profiles of IDC and ILC in relation to normal breast epithelial cells...
  36. pmc Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma. Fibroblastic expression has strong associations with tumor pathology
    E Dublin
    Hedley Atkins Imperial Cancer Research Fund Breast Pathology Laboratory, Guy s Hospital, London
    Am J Pathol 157:1219-27. 2000
    ..Larger prospective studies are needed to confirm these findings...
  37. ncbi Breast cancer: presentation and intervention in women with gastrointestinal metastasis and carcinomatosis
    Elisabeth C McLemore
    Division of General Surgery, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, Arizona 85259, USA
    Ann Surg Oncol 12:886-94. 2005
    Breast cancer metastatic to the gastrointestinal tract or peritoneum is rare. We reviewed the natural history of ductal and lobular carcinoma in women with breast cancer metastatic to the gastrointestinal tract, peritoneum, or both.
  38. ncbi Pleomorphic lobular carcinoma of the breast: clinicopathologic features of 12 cases
    J S Bentz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Mod Pathol 11:814-22. 1998
    Pleomorphic lobular carcinoma (PLC) of the breast was recently identified as a histologic variant of infiltrating lobular carcinoma (ILC) with a poor prognosis...
  39. ncbi Pleomorphic lobular carcinoma of the breast: its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas
    D Frolik
    Institute of Clinical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Histopathology 39:503-13. 2001
    ..METHODS AND RESULTS: The study included 30 cases of pleomorphic lobular carcinoma (PLC; G2 n=15, G3 n=15)...
  40. pmc MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature
    Ritse M Mann
    Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Breast Cancer Res Treat 107:1-14. 2008
    The clinical diagnosis and management of invasive lobular carcinoma (ILC) of the breast presents difficulties. Magnetic resonance imaging (MRI) has been proposed as the imaging modality of choice for the evaluation of ILC...
  41. ncbi Unexpected metastatic lobular carcinoma of the breast with intraabdominal spread and subsequent port-site metastasis after diagnostic laparoscopy for exclusion of ovarian cancer
    Ioannis Mylonas
    First Department of Obstetrics and Gynecology, Ludwig Maximilians University Munich, Munich 80337, Germany
    Gynecol Oncol 95:405-8. 2004
    ..Although lobular carcinomas metastasize primarily to lymph nodes, bone, lung and liver, they can also spread to the gastrointestinal tract, peritoneum and gynecologic organs...
  42. ncbi Preoperative breast MRI in patients with invasive lobular breast cancer
    K Schelfout
    Department of Pathology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Eur Radiol 14:1209-16. 2004
    ..However, false-negative MR findings do occur in a small percentage of ILC...
  43. ncbi Ultrasound morphology of invasive lobular breast cancer is different compared with other types of breast cancer
    Dirk O Watermann
    Department of Obstetrics and Gynecology, University Medical Center, Freiburg, Germany
    Ultrasound Med Biol 31:167-74. 2005
    ..4 +/- 12.0 mm) (p = 0.015). In summary, we found that histologic differentiation significantly influences ultrasonographic appearance of breast cancer. The underestimation of tumor size of ILC might compromise the operative strategy...
  44. ncbi The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile
    M C Mathieu
    Department of Pathology, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif, Cedex, France
    Eur J Cancer 40:342-51. 2004
    ..Preoperative CT did not allow a high rate of conservative treatment for ILC and therefore the use of neoadjuvant CT for ILC patients should be questioned...
  45. ncbi Malignant adenomyoepithelioma of the breast combined with invasive lobular carcinoma
    Yumi Honda
    Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto, Japan
    Pathol Int 59:179-84. 2009
    ..is the first case of malignant adenomyoepithelioma (malignant AME) of the breast combined with invasive lobular carcinoma (ILC) in a 53-year-old woman...
  46. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
    Although lobular carcinoma in situ (LCIS) has traditionally been viewed as a marker of breast cancer risk, recent clinical, pathological and genetic analyses have supported the concept that LCIS is a low risk, direct precursor of ..
  47. ncbi Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma
    V F Cocquyt
    Department of Medical Oncology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium
    Eur J Surg Oncol 29:361-7. 2003
    ..Clinical and pathologic responses are important prognostic parameters. Biologic markers are needed to individualize treatment...
  48. ncbi Lobular carcinoma located in a breast hamartoma
    Catherine Breucq
    Department of Radiology, AZ VUB Jette, Brussels, Belgium
    Breast J 11:508-9. 2005
  49. ncbi Invasive ductal carcinoma and invasive lobular carcinoma of breast differ in response following neoadjuvant therapy with epidoxorubicin and docetaxel + G-CSF
    Catharina Wenzel
    Department of Internal Medicine I, Division of Clinical Oncology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Breast Cancer Res Treat 104:109-14. 2007
    ..We questioned the impact of histologic type invasive ductal carcinoma (IDC) versus invasive lobular carcinoma (ILC) on response to primary chemotherapy.
  50. ncbi Mammographic detection and staging of invasive lobular carcinoma
    Jeroen Veltman
    Department of Radiology, UMC St Radboud, Nijmegen, The Netherlands
    Clin Imaging 30:94-8. 2006
    The aim of the study was to evaluate mammography in detecting and staging of invasive lobular carcinoma (ILC) in order to assess the performance and impact of observer variability...
  51. ncbi Examination of breast conserving therapy in lobular carcinoma
    Megumi Takehara
    Department of Breast Surgery, National Sapporo Hospital, 4 2 Kikusui, Shiroishi ku, Sapporo, Hokkaido 003 0804, Japan
    Breast Cancer 11:69-72. 2004
    Experience with conserving surgery for lobular carcinoma has grown as more breast conserving surgeries have been performed. We examined the results of breast conserving therapy in lobular carcinoma.
  52. ncbi Neoadjuvant chemotherapy in invasive lobular carcinoma may not improve rates of breast conservation
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Surg Oncol 16:1606-11. 2009
    Patients with invasive lobular carcinoma (ILC) experience a lower pathological complete response rate to neoadjuvant chemotherapy than patients with invasive ductal carcinoma...
  53. ncbi CDH1 mutations are present in both ductal and lobular breast cancer, but promoter allelic variants show no detectable breast cancer risk
    Haixin Lei
    Karolinska Institute, Department of Biosciences at Novum, Huddinge, Sweden
    Int J Cancer 98:199-204. 2002
    ..These results do not support CDH1 as a prominent low-penetrance cancer susceptibility gene, but indicate that CDH1 mutations contribute to the progression of both lobular and ductal tumors...
  54. ncbi Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast
    Satomi Kasashima
    Pathology Section, Kanazawa University Hospital, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8641, Japan
    Virchows Arch 450:397-403. 2007
    ..We selected eight cases of histiocytoid features of invasive lobular carcinoma (HLC) and compared with 14 age- and tumor size-matched cases of classical invasive lobular carcinoma (CLC)...
  55. ncbi Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy
    W A Berg
    Departments of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, USA
    Radiology 218:503-9. 2001
    To review outcomes of lesions diagnosed at core-needle breast biopsy as atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS).
  56. ncbi Atypical lobular hyperplasia and classic lobular carcinoma in situ in core biopsy specimens: routine excision is not necessary
    Helena Hwang
    1Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mod Pathol 21:1208-16. 2008
    ..We reviewed 333 cases of atypical lobular hyperplasia or lobular carcinoma in situ without ductal carcinoma in situ or invasive carcinoma diagnosed in core biopsies from 1996 to 2006...
  57. ncbi Cancer upgrades at excisional biopsy after diagnosis of atypical lobular hyperplasia or lobular carcinoma in situ at core-needle biopsy: some reasons why
    Michael A Cohen
    Radiology 231:617-21. 2004
  58. ncbi The effectiveness of MR imaging in the assessment of invasive lobular carcinoma of the breast
    Ritse M Mann
    Department of Radiology, Radboud University Nijmegen Medical Centre, huispost 667, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Magn Reson Imaging Clin N Am 18:259-76, ix. 2010
    Invasive lobular carcinoma (ILC) of the breast is, due to its diffuse infiltrative growth pattern, a diagnostic challenge. Even in retrospect, only up to 80% are visible at mammography...
  59. ncbi Lobular neoplasia on core-needle biopsy--clinical significance
    Grazia Arpino
    Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030, USA
    Cancer 101:242-50. 2004
    ..The goal of the current study was to determine the incidence of breast carcinoma at sites of core biopsy exhibiting LN compared with sites of core biopsy exhibiting ADH...
  60. ncbi ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis
    F Revillion
    Laboratoire d Oncologie Moléculaire Humaine, Centre Oscar Lambret, BP 307, 59020 Lille Cedex, France
    Ann Oncol 19:73-80. 2008
    ..The aim of this study is to provide an expression profile of ErbB/HER ligands in breast cancer. We analysed the relationships with their receptors, the bio-pathological features and prognosis...
  61. ncbi Solid low-grade in situ carcinoma of the breast: role of associated lesions and E-cadherin in differential diagnosis
    H M Maluf
    Department of Pathology and Immunology, Washington University Medical School, St Louis, Missouri 63110-1093, USA
    Am J Surg Pathol 25:237-44. 2001
    ....
  62. ncbi Age-related lobular involution and risk of breast cancer
    Tia R Milanese
    Mayo Medical School, Rochester, MN 55905, USA
    J Natl Cancer Inst 98:1600-7. 2006
    ..As women age, the lobules in their breasts undergo involution or regression. We investigated whether lobular involution in women with benign breast disease was associated with subsequent breast cancer risk...
  63. ncbi Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia
    Aphrodite Nonni
    1st Department of Pathology, Medical School, University of Athens, Athens, Greece
    Virchows Arch 451:893-7. 2007
    The designation lobular neoplasia (LN) of the breast includes atypical lobular hyperplasia and lobular carcinoma in situ. Estrogen receptors (ER) play a significant role in breast carcinogenesis...
  64. ncbi Excisional biopsy should be performed if lobular carcinoma in situ is seen on needle core biopsy
    Sandra J Shin
    Department of Pathology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
    Arch Pathol Lab Med 126:697-701. 2002
    ..Infrequently, a diagnosis of a primary lobular lesion is rendered by needle core biopsy. Although lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) are not themselves detectable by mammography, they can ..
  65. ncbi Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 107:331-5. 2008
    b>Lobular carcinoma in situ (LCIS) of the breast is generally considered an indicator for a bilaterally increased risk of invasive breast cancer (IBC)...
  66. pmc Expression of c-erbB3 protein in primary breast carcinomas
    R Naidu
    Department of Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia
    Br J Cancer 78:1385-90. 1998
    ....
  67. ncbi E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance
    E A Rakha
    The Breast Unit, Department of Histopathology and Division of Respiratory Medicine, Nottingham City Hospital NHS Trust, University of Nottingham, Nottingham, UK
    Histopathology 46:685-93. 2005
    ..However, the clinicopathological and prognostic value of E-cadherin in the more frequent non-lobular types of breast carcinoma is unclear...
  68. ncbi Invasive lobular carcinoma arising in phyllodes tumor of the breast
    Takahide Kodama
    Virchows Arch 442:614-6. 2003
  69. ncbi The diffuse type of invasive lobular carcinoma of the breast: morphology and prognosis
    Tibor Tot
    Department of Pathology, Falun Central Hospital, 79182 Falun, Sweden
    Virchows Arch 443:718-24. 2003
    Invasive lobular carcinoma (ILC) of the breast represents a heterogeneous group of tumors, which can be classified according to the histological growth pattern into classic ILC and its variants and according to the cytomorphological ..
  70. ncbi FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
    Jorge Sergio Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 12:6652-62. 2006
    ..However, little is known about the putative therapeutic targets for these tumors. The aim of this study was to characterize CLCs at the molecular genetic level and identify putative therapeutic targets...
  71. ncbi Rectal metastasis from lobular carcinoma of the breast: a case report
    Melita Perić Balja
    Department of Pathology, University Hospital for Tumors, Zagreb, Croatia
    Coll Antropol 34:719-21. 2010
    ..We present a case of 83-year old woman with rectal metastesis from ILC seven years after surgery of primary tumor...
  72. ncbi MR imaging of the ipsilateral breast in women with percutaneously proven breast cancer
    Laura Liberman
    Breast Imaging Section, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    AJR Am J Roentgenol 180:901-10. 2003
    ..The purpose of this study was to review MR imaging findings in the ipsilateral breast in women with percutaneously proven breast cancer...
  73. ncbi Lobular carcinoma in ectopic axillary breast tissue
    Gladys L Giron
    Department of Surgery, Beth Israel Center, New York, New York 10003, USA
    Am Surg 70:312-5. 2004
    ..We present the case of a lobular carcinoma arising in axillary ectopic breast tissue. Although this has previously been reported, it is a rare entity.
  74. ncbi Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy
    Serkan Erkanli
    Department of Obstetrics and Gynecology, Baskent University School of Medicine, Seyhan Adana, Turkey
    Breast 15:558-61. 2006
    ..We report a case of metastatic lobular carcinoma of the breast in a 63-year-old patient on adjuvant anastrozole therapy for 8 months...
  75. ncbi Invasive lobular carcinoma of the breast: should this be regarded as a chronic disease?
    I F Anwar
    Breast Surgery Unit, Norfolk and Norwich University Hospital, Norwich, UK
    Int J Surg 8:346-52. 2010
    The surgical treatment of patients with invasive lobular carcinoma is still controversial due to its different clinical and pathological features...
  76. ncbi Cytological features of lobular carcinoma of breast: how important are the intracytoplasmic lumina?
    Julian A Crasta
    Department of Pathology, St John s Medical College, Sarjapura Road, Bangalore 34
    Indian J Pathol Microbiol 48:170-2. 2005
    b>Lobular carcinoma is the most common pitfall in the cytodiagnosis of breast lesions. Of the cytological features described intracytoplasmic lumina are stressed by many authors as an important diagnostic feature...
  77. ncbi Uptake and washout of 99mTcV-dimercaptosuccinic acid and 99mTc-sestamibi in the assessment of histological type and grade in breast cancer
    V Papantoniou
    Department of Nuclear Medicine, Alexandra Hospital, University of Athens, Greece
    Nucl Med Commun 23:461-7. 2002
    ....
  78. ncbi The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)?
    Sunil R Lakhani
    Molecular and Cellular Pathology, School of Medicine, The University of Queensland, Mayne Medical School, Brisbane, QLD 4006, Australia
    Eur J Cancer 42:2205-11. 2006
    b>Lobular carcinoma in situ was first described over 60 years ago. Despite the long history, it continues to pose significant difficulties in screening, diagnosis, management and treatment...
  79. ncbi Breast conservation therapy for invasive lobular carcinoma: the impact of lobular carcinoma in situ in the surgical specimen on local recurrence and axillary node status
    A J Stolier
    Department of Surgery, Louisiana State University, and The Stanley S Scott Cancer Center, New Orleans, Louisiana, USA
    Am Surg 70:818-21. 2004
    Forty patients undergoing breast-conserving therapy for invasive lobular carcinoma were studied for the volume of lobular carcinoma in situ (LCIS) in the surgical specimen and its relationship to the surgical margins...
  80. pmc Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 164:2269-78. 2004
    ..inactivation in cancer, we examined the expression and localization of E-cadherin-associated proteins in lobular carcinoma, in which the E-cadherin gene is frequently inactivated, and found that E-cadherin down-regulation ..
  81. ncbi Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast
    Emad A Rakha
    Department of Histopathology, Nottingham University Hospitals NHS Trust, UK
    Am J Surg Pathol 34:1472-9. 2010
    Although virtually all cases of lobular carcinoma in situ lack E-cadherin expression, a proportion of morphologically typical invasive lobular carcinomas (ILCs) retain its expression...
  82. ncbi DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
    Mary Jo Fackler
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Int J Cancer 107:970-5. 2003
    ..01). These results suggest that these 2 types of tumors share many common methylation patterns and some molecular differences. Additional studies might lend further understanding into the etiology and clinical behavior of this tumor type...
  83. ncbi Robotic-assisted laparoscopic cytoreductive surgery for lobular carcinoma of the breast metastatic to the ovaries
    Peter A van Dam
    Department of Obstetrics and Gynecology, Sint Augustinus Hospital Antwerp, Belgium
    J Minim Invasive Gynecol 14:746-9. 2007
    ..Histologic examination showed strongly estrogen receptor-positive metastatic lobular carcinoma of the breast in both ovaries and fallopian tubes...
  84. pmc Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res 4:R7. 2002
    ..We conducted the present study to determine whether breast cancer morphology is genetically determined...
  85. ncbi Important increase of invasive lobular breast cancer incidence in Geneva, Switzerland
    Helena Marieke Verkooijen
    Geneva Cancer Registry, Institute for Social and Preventive Medicine, University of Geneva, Geneva, Switzerland
    Int J Cancer 104:778-81. 2003
    ..Breast histology was classified as ductal carcinoma, lobular carcinoma and other. Incidence trends were studied by log-linear regression analyses...
  86. ncbi The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK
    Histopathology 54:419-27. 2009
    To determine the status of oestrogen receptor (ER) subtypes (ERalpha and ERbeta) in lobular carcinoma in situ (LCIS) of the breast.
  87. ncbi Apocrine differentiation in invasive pleomorphic lobular carcinoma with in situ ductal and lobular apocrine carcinoma: case report
    Handan Kaya
    Department of Pathology, Marmara University Hospital, Istanbul, 81190, Turkey
    Pathol Oncol Res 8:151-2. 2002
    Invasive pleomorphic lobular carcinoma (PLC) is a distinctive aggressive subtype of invasive lobular carcinomas (ILC). We report one case of PLC with in situ PLC and ductal carcinoma in situ with apocrine features.
  88. ncbi Invasive lobular carcinoma: detection with mammography, sonography, MRI, and breast-specific gamma imaging
    Rachel F Brem
    Department of Radiology, Breast Imaging and Interventional Center, George Washington University Medical Center, NW, Washington, DC 20037, USA
    AJR Am J Roentgenol 192:379-83. 2009
    The objective of our study was to compare the sensitivity of mammography, sonography, MRI, and breast-specific gamma imaging (BSGI) in the detection of invasive lobular carcinoma.
  89. ncbi Primary signet ring cell carcinoma of the eyelid: report of a case demonstrating further analogy to lobular carcinoma of the breast with a literature review
    D J Langel
    Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Am J Dermatopathol 23:444-9. 2001
    ..This report details another case, which shows further parallels to lobular carcinoma of the breast, and reviews the literature on this subject...
  90. ncbi Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation
    Lydia Nakopoulou
    Department of Pathology, Medical School, University of Athens, Greece
    Hum Pathol 33:863-70. 2002
    ..On the other hand, the inverse correlation of Flk-1 with TIMP-1 mRNA in intratumoral stromal cells supports the notion that TIMP-1 may have an inhibitory role on angiogenesis...
  91. ncbi Rectal metastases from lobular carcinoma of the breast: report of a case and literature review
    A Bamias
    Department of Medical Oncology, Ioannina University Hospital, Greece
    Ann Oncol 12:715-8. 2001
    ..Literature review revealed only a few more cases of metastatic breast carcinoma to the rectum. Awareness of this condition may lead to accurate diagnosis and early initiation of systemic treatment, thus avoiding surgical intervention...
  92. pmc No significant association of Epstein-Barr virus infection with invasive breast carcinoma
    P G Chu
    Division of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Am J Pathol 159:571-8. 2001
    ....
  93. ncbi Neoadjuvant vinorelbine-capecitabine versus docetaxel-doxorubicin-cyclophosphamide in early nonresponsive breast cancer: phase III randomized GeparTrio trial
    Gunter von Minckwitz
    German Breast Group, Frankfurt, Germany
    J Natl Cancer Inst 100:542-51. 2008
    ..We compared the response of nonresponding patients who continued the same treatment with that of patients who switched to a well-tolerated non-cross-resistant regimen...
  94. ncbi Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial
    B Fisher
    National Surgical Adjuvant Breast and Bowel Project, Allegheny University of the Health Sciences, Pittsburgh, PA 15212 5234, USA
    Lancet 353:1993-2000. 1999
    ..We did a double-blind randomised controlled trial to find out whether lumpectomy, radiation therapy, and tamoxifen was of more benefit than lumpectomy and radiation therapy alone for DCIS...
  95. ncbi The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast
    R M Mann
    Department of Radiology, Radboud University Nijmegen, Medical Centre, huispost 667, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Breast Cancer Res Treat 119:415-22. 2010
    Re-excision rates after breast conserving surgery(BCS) of invasive lobular carcinoma (ILC) are high.Preoperative breast MRI has the potential to reduce re-excision rates, but may lead to an increased rate of mastectomies...
  96. ncbi Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer
    Christopher I Li
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 C308, P O Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:946-54. 2006
    ....
  97. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
    ....
  98. ncbi Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Clin Pathol 115:85-98. 2001
    ..In tumors with histologically equivocal features, immunohistochemical detection of E-cadherin expression can be a useful diagnostic tool for the differentiation of ductal and lobular carcinomas of the breast...
  99. ncbi Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis
    C Y Shen
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Cancer Res 60:3884-92. 2000
    ..Therefore, this study suggests that breast cancer progression is clonal with regard to CIN, but different breast cancers would present distinct molecular profiles resulting from genetic heterogeneity caused by CIN...
  100. ncbi Risk of mortality by histologic type of breast cancer among women aged 50 to 79 years
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Wash 98109, USA
    Arch Intern Med 163:2149-53. 2003
    ..combined estrogen and progestin hormone replacement therapy is associated with an increased risk of invasive lobular carcinoma (ILC), but that it has little association with risk of invasive ductal carcinoma (IDC)...
  101. pmc Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast
    Yunn Yi Chen
    Department of Pathology, University of California San Francisco, California 94143, USA
    Am J Surg Pathol 33:1683-94. 2009
    The clinical, pathologic, and molecular features of pleomorphic lobular carcinoma in situ (PLCIS) and the relationship of PLCIS to classic LCIS (CLCIS) are poorly defined...

Research Grants47

  1. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..and its associated biological activities in women with a recent diagnosis of ductal carcinoma in situ, lobular carcinoma in situ, or atypical ductal hyperplasia elected to undergo excision surgery...
  2. Migraine, Migraine Medication Use, and Risk of Breast Cancer
    Christopher I Li; Fiscal Year: 2010
    ..In order to compare invasive ductal and invasive lobular carcinoma cases to controls, polytomous logistic regression will be used to calculate odds ratios (ORs) and 95% ..
  3. Cellular Hyperthermia for Breast Cancer Detection and Monitoring
    ERDEM TOPSAKAL; Fiscal Year: 2011
    ..and fabricate realistic breast phantoms and antennas for radiometers to detect early stages of ductal and lobular carcinoma. Once diagnosed, the radiometer will be used to monitor the cancer's activity...
  4. RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCER
    Linda Titus Ernstoff; Fiscal Year: 1999
    ..We will evaluate risk factors for BCIS and its major subtypes, lobular carcinoma in situ (LCIS), ductal carcinoma in sine (DCIS), and the aggressive DCIS subtype (comedo-type DCIS)...
  5. HIN-1,A Novel Putative Breast Tumor Suppressor Gene
    Kornelia Polyak; Fiscal Year: 2006
    ..in 95% of human breast carcinoma specimens including early stage breast carcinomas such as ductal and lobular carcinoma in-situ...
  6. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  8. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?;and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  9. Synergy of Inverse Scatter & Vibro-Acoustics
    Steven Johnson; Fiscal Year: 2004
    ..MC) in patterns, which simulate benign and cancerous tissues, such a Ductile Carcinoma In Situ (DCIS) and Lobular Carcinoma (LC)...
  10. Add-on module for ONCAD for diagnosing infiltrating lobular carcinoma
    Alan Penn; Fiscal Year: 2008
    ..provide radiologists with additional assistance when they have suspicion of the presence of infiltrating lobular carcinoma (ILC)...
  11. Funtional Proteomics and Response to Preoperative Theraphy in Breast Cancer
    Ana Gonzalez Angulo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. LONG TERM OUTCOMES FOR WOMEN WITH BREAST CA IN SITU
    Elizabeth Claus; Fiscal Year: 2004
    ..The data are unique in that epidemiologic, biologic and clinical variables will have been collected allowing us to study the relationship of these variables with long term outcome. ..
  13. Meningioma: Risk Factors and Quality of Life
    Elizabeth B Claus; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  14. Breast Carcinoma In-Situ: Mammographic Risk Factors
    Elizabeth Claus; Fiscal Year: 2007
    ..abstract_text> ..
  15. First International Inflammatory Breast Cancer Conference
    Massimo Cristofanilli; Fiscal Year: 2008
    ..For project details please see "Conference Plan". [unreadable] [unreadable] [unreadable]..
  16. Biology of Breast Cancers Arising in Older Women
    Christopher Benz; Fiscal Year: 2007
    ..abstract_text> ..
  17. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Genetic Regulation of Human Breast Cancer Dormancy
    NANCY DEMORE; Fiscal Year: 2008
    ..These genes could be pharmacogenomic targets for future treatment strategies. ..
  19. Optimized Compression for Telepathology Virtual Slides
    Elizabeth Krupinski; Fiscal Year: 2009
    ....
  20. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2008
    ..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..
  21. Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis
    Min Ying Su; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. HRT USE AND RISK OF LOBULAR AND DUCTAL BREAST CANCER
    Janet Daling; Fiscal Year: 2004
    ..of CHRT associated with alteration in the histologic characteristics, tumor cell proliferation, or expression of steroid hormone receptors, oncogenes, and cell cycle and cell death regulator proteins of lobular and ductal breast cancers? ..
  23. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  24. A LONGITUDINAL STUDY IN THE CANINE MODEL OF HUMAN AGING
    Min Ying Su; Fiscal Year: 2005
    ..Noninvasive MR imaging techniques may offer a means of detecting early signs of pathological aging, allowing us the opportunity to initiate interventions to slow disease progression. ..
  25. Biomarker modulation/COX-2 inhibitor/Breast Cancer
    Banu Arun; Fiscal Year: 2003
    ..Forty high-risk women (history of previous breast cancer or history of lobular carcinoma in situ or estimated 5 year Gail risk > 1...
  26. OPTIMIZING SOFTCOPY DISPLAYS FOR DIGITAL MAMMOGRAPHY
    Elizabeth Krupinski; Fiscal Year: 2003
    ..The JND metrix model will then be used to systematically explore and optimize CRT design tradeoffs for current and future digital-mammography display systems. ..
  27. CONVERGENT MECHANISMS CONTRIBUTING TO CANCER
    Joseph Costello; Fiscal Year: 2006
    ....
  28. Conference--Medical Image Perception
    Elizabeth Krupinski; Fiscal Year: 2003
    ..This grant will be used to provide financial support for about 12 graduate students and residents, as well as logistic support for publicity and program printing. ..
  29. CALCIUM CHANNEL BLOCKERS IN BREAST CANCER ETIOLOGY
    Janet Daling; Fiscal Year: 2001
    ..cimetidine, anti-depressants, lipid lowering drugs) frequently used by women in this age group. ..
  30. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  31. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2002
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  32. OPTIMIZING SOFTCOPY DISPLAYS FOR DIGITAL MAMMOGRAPHY
    Elizabeth Krupinski; Fiscal Year: 2002
    ..The JND metrix model will then be used to systematically explore and optimize CRT design tradeoffs for current and future digital-mammography display systems. ..
  33. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  34. THERAPEUTIC MODULATION OF BREAST CANCER ONCOGENES
    Christopher Benz; Fiscal Year: 2007
    ..tumor-targeted uptake of selected candidates by encapsulation into anti-ErbB2 immunoliposomes (ILs), and these ErbB2 receptor- and promoter-targeted ILs agents will be evaluated in vivo for further clinical development ..
  35. Global Summit on International Breast Health-Implementation
    Benjamin Anderson; Fiscal Year: 2007
    ..The resulting 2007 Implementation Guidelines will serve as a practical medical tool providing functional real world examples of "how to implement" best practices with limited health care resources. [unreadable] [unreadable] [unreadable]..
  36. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  37. Small Field of View Gamma Camera for Scintimammography
    Michael O Connor; Fiscal Year: 2005
    ..abstract_text> ..
  38. Exposure Insights Using GIS in a Case-Control Study
    Peggy Reynolds; Fiscal Year: 2006
    ....
  39. Medical Image Perception Society Confrence XI
    Elizabeth Krupinski; Fiscal Year: 2005
    ..abstract_text> ..
  40. MIPS XII Conference
    Elizabeth Krupinski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Socioeconomic Disparities in Survival After Hodgkin Lym*
    THERESA KEEGAN; Fiscal Year: 2005
    ....
  42. The impact of the built environment on the risk of breast cancer
    THERESA KEEGAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. A Genetic Mapping Resource for Zebrafish
    Jeffrey Smith; Fiscal Year: 2007
    ..abstract_text> ..
  44. Fostering Independence in Nursing and Outcomes Research
    Christopher Friese; Fiscal Year: 2009
    ..The research projects examine the relationship between the nursing practice environment and outcomes of care for patients with cancer. ..
  45. Treatment of Older Patients with Early Breast Cancer
    Arash Naeim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..