oxyphilic adenoma

Summary

Summary: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.

Top Publications

  1. ncbi Renal tumors in the Birt-Hogg-Dubé syndrome
    Christian P Pavlovich
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute NIH, Bldg 10 Rm 2N212, Bethesda, MD 20892, USA
    Am J Surg Pathol 26:1542-52. 2002
  2. ncbi C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas
    Lei Huo
    Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Hum Pathol 36:262-8. 2005
  3. ncbi Molecular genetics and histopathologic features of adult distal nephron tumors
    Thomas J Polascik
    Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Urology 60:941-6. 2002
  4. pmc High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    Maria V Yusenko
    Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 9:152. 2009
  5. ncbi Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis
    M Jinzaki
    Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan
    J Comput Assist Tomogr 24:835-42. 2000
  6. ncbi Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III
    Elena Bonora
    Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Italy
    Cancer Res 66:6087-96. 2006
  7. ncbi Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patients
    William W Mayo-Smith
    Department of Diagnostic Imaging, Rhode Island Hospital, Brown Medical School, 593 Eddy St, Providence 02903, USA
    AJR Am J Roentgenol 180:1503-8. 2003
  8. ncbi Adrenocortical oncocytic tumors: report of 10 cases and review of the literature
    Michele Bisceglia
    Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo FG, Italy
    Int J Surg Pathol 12:231-43. 2004
  9. ncbi Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma
    Johannes A Mayr
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Clin Cancer Res 14:2270-5. 2008
  10. ncbi The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, 80131 Napoli, Italy
    J Clin Endocrinol Metab 87:364-9. 2002

Research Grants

Detail Information

Publications191 found, 100 shown here

  1. ncbi Renal tumors in the Birt-Hogg-Dubé syndrome
    Christian P Pavlovich
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute NIH, Bldg 10 Rm 2N212, Bethesda, MD 20892, USA
    Am J Surg Pathol 26:1542-52. 2002
    ..Recognition by the pathologist of the unusual renal tumors associated with BHD may assist in the clinical diagnosis of the syndrome...
  2. ncbi C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas
    Lei Huo
    Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Hum Pathol 36:262-8. 2005
    ..In contrast, immunohistochemical expression of KIT was not detected in most other types of renal cell tumors evaluated. The differential expression of c- kit in these renal tumors may have diagnostic and therapeutic implications...
  3. ncbi Molecular genetics and histopathologic features of adult distal nephron tumors
    Thomas J Polascik
    Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Urology 60:941-6. 2002
  4. pmc High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    Maria V Yusenko
    Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 9:152. 2009
    ..The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases...
  5. ncbi Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis
    M Jinzaki
    Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan
    J Comput Assist Tomogr 24:835-42. 2000
    ....
  6. ncbi Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III
    Elena Bonora
    Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Italy
    Cancer Res 66:6087-96. 2006
    ..UC1 is due to a combined complex I/III defect associated with mtDNA mutations, as proven by the transfer of the defective energetic phenotype with the mitochondrial genome into the cybrids...
  7. ncbi Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patients
    William W Mayo-Smith
    Department of Diagnostic Imaging, Rhode Island Hospital, Brown Medical School, 593 Eddy St, Providence 02903, USA
    AJR Am J Roentgenol 180:1503-8. 2003
    ..The purpose of this study was to describe the treatment techniques and results of 38 consecutive imaging-guided percutaneous radiofrequency ablations of solid renal masses performed in 32 patients...
  8. ncbi Adrenocortical oncocytic tumors: report of 10 cases and review of the literature
    Michele Bisceglia
    Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo FG, Italy
    Int J Surg Pathol 12:231-43. 2004
    ..7 months). The 2 benign tumors have a follow-up of 25 and 30 months, respectively. Diagnostic difficulties are delineated and a complete review of the literature on this topic has also been performed...
  9. ncbi Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma
    Johannes A Mayr
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
    Clin Cancer Res 14:2270-5. 2008
    ....
  10. ncbi The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, 80131 Napoli, Italy
    J Clin Endocrinol Metab 87:364-9. 2002
    ..In particular, the RET/PTC1 isoform was found in 7 of 12 adenomas and 4 of 7 carcinomas. These results would indicate that RET/PTC is a genetic event common to papillary carcinomas and to Hurthle cell neoplasias...
  11. ncbi Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies
    J Liu
    Section of Cytopathology, Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 93:390-7. 2001
    ..The authors retrospectively studied the cytologic features and ancillary study findings of RO compared with findings in RCCs with eosinophilic granular cytoplasm to evaluate the reliability of FNA-based diagnosis of RO...
  12. ncbi Changing concepts in the management of renal oncocytoma
    Debby H Chao
    Division of Urologic Oncology, Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 59:635-42. 2002
  13. pmc A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2
    F Canzian
    Unit of Genetic Cancer Susceptibility, International Agency for Research on Cancer, Lyon, France
    Am J Hum Genet 63:1743-8. 1998
    ..These findings suggest that the relatives of patients affected with sporadic NMTC with cell oxyphilia should be carefully investigated...
  14. ncbi Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer
    B Göhring
    Department of Urology, Martin Luther University Halle Wittenberg, Halle, Germany
    Int J Mol Med 2:409-14. 1998
    ..Aminopeptidase N (APN) and aminopeptidase A (APA) show attenuated expression in up to one third of clear cell/ chromophilic RCC. Chromophobe RCC and oncocytomas do not express APN, APA, NEP and gamma-glutamyltranspeptidase...
  15. pmc Metastatic renal oncocytoma
    J D Oxley
    Department of Cellular Pathology, North Bristol NHS Trust, Southmead Hospital, Westbury on Trym, Bristol, UK
    J Clin Pathol 60:720-2. 2007
  16. ncbi Oncocytic tumours
    G Tallini
    Department of Pathology, Yale New Haven Hospital, CT 06510, USA
    Virchows Arch 433:5-12. 1998
    ....
  17. ncbi Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors
    F Savagner
    INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, 4rue Larrey, F 49033 Angers cedex 01, France
    J Clin Endocrinol Metab 86:4920-5. 2001
    ..Adenosine triphosphate synthesis was significantly lower in all the tumors, compared with controls, suggesting that a coupling defect in oxidative phosphorylation may be a cause of mitochondrial hyperplasia in oxyphilic thyroid tumors...
  18. ncbi Hürthle cell carcinoma: a 60-year experience
    Alexander Stojadinovic
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 9:197-203. 2002
    ..The aim of this study was to define the clinical behavior and prognostic indicators of outcome in Hürthle cell cancer (HCC)...
  19. ncbi PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma
    Frederique Savagner
    INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, CHU, Angers, France
    Biochem Biophys Res Commun 310:779-84. 2003
    ..However, no mtDNA variant in the D-loop region appeared to be involved in oncocytic development. We conclude that overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma...
  20. ncbi The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 cases
    C C Pan
    Department of Pathology, National Yang Ming University, and Taipei Veterans General Hospital, Taipei, Taiwan
    Histopathology 45:452-9. 2004
    ..To demonstrate the diagnostic utility of MOC31, BerEP4, renal cell carcinoma marker (RCC Ma) and CD10 in the classification of RCC and renal oncocytoma, based upon a comprehensive immunohistochemical analysis...
  21. ncbi Mitochondrial activity in XTC.UC1 cells derived from thyroid oncocytoma
    F Savagner
    INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, Faculte de Medecine, Angers, France
    Thyroid 11:327-33. 2001
    ..XTC.UC1 cells may therefore offer a useful model for investigating the coordination of the nuclear and mitochondrial genomes, in the context of thyroid tumors...
  22. ncbi Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Clin Cancer Res 11:6558-66. 2005
    ..Whether these renal tumors can be distinguished by their mRNA expression profile of a few selected genes was examined...
  23. ncbi Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma
    Lorena Blanco
    Dept of Physiology, Faculty of Medicine and Dentistry, Univ of the Basque Country, P O Box 699, E 48080 Bilbao, Bizkaia, Spain
    Am J Physiol Renal Physiol 294:F850-8. 2008
    ..These results may suggest an involvement of several peptidases in the pathophysiology of renal cancer, since they presented different patterns of activity and expression in tumors with different behaviors...
  24. ncbi Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma
    Giuseppe Gasparre
    Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Bologna, Italy
    Hum Mol Genet 17:986-95. 2008
    ..We hypothesize that functional deficiency of the oxidative phosphorylation CI could create a loop of amplification of mitochondria during cell division, impair substrates oxidation and increase intermediary metabolites availability...
  25. ncbi Mitochondrial complex I is deficient in renal oncocytomas
    Helene Simonnet
    CGMC Center of Molecular and Cell Genetics, Unit 5534 of the CNRS and the University Lyon 1 Claude Bernard, Villeurbanne, France
    Carcinogenesis 24:1461-6. 2003
    ..This suggested that oncocytomas are the result of at least two serial modifications altering the mitochondrial respiratory chain...
  26. ncbi Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors
    Olivier Baris
    Institut National de la Sante et de la Recherche Medicale, Equipe Mixte INSERM Universitaire 0018, Laboratoire de Biochimie et Biologie Moleculaire, Centre Hospitalier Universitaire, Angers F 49033, France
    J Clin Endocrinol Metab 89:994-1005. 2004
    ..On the contrary, the lactate dehydrogenase A gene, involved in anaerobic metabolism, was down-regulated. Our results suggest that, unlike a large number of solid tumors, thyroid oncocytomas produce energy through an aerobic pathway...
  27. ncbi Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma
    Anett Nagy
    Laboratory of Molecular Oncology, Department of Urology, Ruprecht Karls University, Heidelberg, Germany
    Int J Cancer 109:472-5. 2004
    ..Our data suggest the folliculin gene does not play a role in the tumorigenesis of sporadic chromophobe RCCs and renal oncocytomas...
  28. ncbi Cytokeratins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomas
    Sang Ling Wu
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
    Mod Pathol 15:712-7. 2002
    ..Despite the technical and interpretive challenges of Hale's colloidal iron, it is still the most useful stain in differentiating chromophobe renal cell carcinomas from renal oncocytomas...
  29. ncbi Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes
    Stephen Rohan
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 12:6937-45. 2006
    ..To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes...
  30. ncbi From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue
    Zhengping Zhuang
    Surgical Neurology Branch, NINDS NIH, Bethesda, MD 20892, USA
    Int J Oncol 28:103-10. 2006
    ..This new combination of techniques allows not only for sensitive identification of specific protein patterns that correspond to a histological tumor phenotype, but also for identification of specific disease-associated protein targets...
  31. ncbi Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes
    A Nagy
    Laboratory of Molecular Oncology, Department of Urology, Ruprecht Karls University, Heidelberg, Germany
    Histopathology 44:542-6. 2004
    ..To assess the value of genetic analysis in their differential diagnosis we analysed 27 ROs and 21 chromophobe RCCs by microsatellite allelotyping...
  32. ncbi Chromophobe renal cell carcinoma: a comparative study of histological, immunohistochemical and ultrastructural features using high throughput tissue microarray
    N A Abrahams
    The Cleveland Clinic Foundation, Cleveland, OH, USA
    Histopathology 45:593-602. 2004
    ..Electron microscopy was performed, as a diagnostic gold standard, on all of the cases...
  33. ncbi Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases
    Ronald A Ghossein
    Department of Pathology Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 106:1669-76. 2006
    ..Because to the authors' knowledge most studies do not focus exclusively on the encapsulated Hurthle cell carcinoma (EHC), the current study attempted to identify predictors of recurrence in EHC...
  34. ncbi Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma
    Peter R Mazal
    Department of Clinical Pathology, Medical University of Vienna, Austria
    Hum Pathol 36:22-8. 2005
    ....
  35. ncbi Adrenocortical oncocytoma: a case report and review of literature
    Gargah T Tahar
    Department of Pediatrics, Charles Nicolle Hospital, Tunis, Tunisia
    J Pediatr Surg 43:E1-3. 2008
    ..She had an adrenalectomy. The tumor was small and composed predominantly of oncocytes. No criteria of malignancy were found. A discussion of this case and a review of the literature on this entity are presented...
  36. ncbi Losses of 1p and chromosome 14 in renal oncocytomas
    Laszlo Fuzesi
    Department of Pathology, Georg August Universitat Gottingen, Robert Koch Strabe 40, Postfach 3032, Göttingen D 37075, Germany
    Cancer Genet Cytogenet 160:120-5. 2005
    ..In the latter cytogenetic subgroup, monosomy 14 was additionally accompanied by either monosomy 1 in 2 cases or loss of 1p in a third case, providing insights in the cytogenetic evolution of this subgroup...
  37. ncbi Metastatic adrenocortical oncocytoma: a case report
    Justin J Juliano
    Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA
    Urol Oncol 26:198-201. 2008
    ..The first case of metastatic adrenocortical oncocytoma is reported along with an update of the literature. A role for radiotherapy in the palliative setting is demonstrated...
  38. pmc Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer
    J D McKay
    Menzies Center for Population Health Research, Hobart, Tasmania, Australia
    J Med Genet 41:407-12. 2004
    ..Familial non-medullary thyroid cancer (fNMTC) is a complex genetic disorder that is more aggressive than its sporadic counterpart. Thus far, three genetic loci have been implicated in susceptibility to fNMTC by linkage analysis...
  39. ncbi Renal oncocytosis presenting in childhood: a case report
    Terina S Chen
    Department of Pathology and Laboratory Medicine, Rochester, New York 14642, USA
    Int J Surg Pathol 11:325-9. 2003
    ..We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients...
  40. ncbi Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization
    Maria M Picken
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Clin Pathol 129:377-82. 2008
    ..Determining whether such abnormalities are unique to renal oncocytomas or are also present in other tumors requires further studies...
  41. ncbi Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis
    Ozgur Mete
    Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Temel Bilimler Binasi, 2 Bodrum, Capa, Istanbul, Turkey
    Virchows Arch 447:938-46. 2005
    ..We recommend using CD63 as the best marker of choice for distinguishing ROs from eosinophilic chromophobe RCCs when standard diagnostic criteria are not helpful...
  42. pmc Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors
    Valdemar Máximo
    Institute of Molecular Pathology and Immunology, The University of Porto, Porto, Portugal
    Am J Pathol 160:1857-65. 2002
    ..Germline polymorphisms of the ATPase 6 gene are associated with the occurrence of mtDNA CD, the hallmark of Hürthle cell tumors...
  43. ncbi Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumors derived from gene expression profiling studies using cDNA microarrays
    Andrew N Young
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 27:199-205. 2003
    ..This work demonstrates that a useful panel of immunohistochemical markers can be derived from differential gene expression profiles determined using cDNA microarrays...
  44. ncbi High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene
    Kathryn Farrand
    Department of Pathology and Molecular Medicine, Wellington School of Medicine, New Zealand
    J Clin Endocrinol Metab 87:4715-21. 2002
    ..These data suggest that a TSG, involved in HCC pathogenesis, is contained within the D17S1308-D17S695 interval. There are several potential candidate TSGs in this region that are worthy of further study...
  45. ncbi Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma
    N Kuroda
    First Department of Pathology, Kochi Medical School, Nankoku City, Japan
    Appl Immunohistochem Mol Morphol 9:315-8. 2001
    ..In addition, paxillin may be an available marker in distinguishing chromophobe RCCs from conventional or papillary RCCs...
  46. ncbi Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study
    Peter R Mazal
    Department of Clinical Pathology, Medical University of Vienna, AKH Vienna, Vienna, Austria
    Mod Pathol 18:535-40. 2005
    ..Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading...
  47. ncbi Role of color flow Doppler sonography in pre-operative diagnostics of the thyroid pathology
    M Giammanco
    Department of Surgical, Anatomical and Oncological Science, University of Palermo, Italy
    Minerva Endocrinol 27:1-10. 2002
    ....
  48. ncbi Renal cell carcinoma metastatic to Hurthle cell adenoma of thyroid
    Lian Qian
    Division of Surgical Pathology Department of Pathology University of Texas Medical Branch, Galveston, TX 77555 0588, USA
    Ann Diagn Pathol 8:305-8. 2004
    ..The possibility of metastatic RCC should always be taken under consideration, especially when nests of clear cells are seen infiltrating into the thyroid parenchyma or neoplasm...
  49. ncbi An immunohistochemical approach to the differential diagnosis of renal tumors
    Brian F Skinnider
    Department of Pathology, Vancouver General Hospital and University of British Columbia, Canada
    Semin Diagn Pathol 22:51-68. 2005
    ....
  50. ncbi Radiology-Pathology Conference: Bilateral renal oncocytomas
    Lewis K Shin
    Department of Radiology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Clin Imaging 28:344-8. 2004
    ..Accurate preoperative diagnosis and differentiation from renal carcinoma is difficult. We report the radiology and pathology of a patient with bilateral renal oncocytomas and review the literature of this rare presentation...
  51. ncbi Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients
    Lee R Schachter
    Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0001, USA
    J Endourol 21:819-23. 2007
    ..This study sought to determine the incidence of the various histologic subtypes of renal cortical tumors according to size in a contemporary series of surgically treated patients...
  52. ncbi Sonography in the diagnosis of cervical recurrence in patients with differentiated thyroid carcinoma
    Pedro Weslley Souza do Rosário
    Department of Thyroid, Endocrinology and Metabolism Service of Santa Casa de Belo Horizonte, Minas Gerais, Brazil
    J Ultrasound Med 23:915-20; quiz 921-2. 2004
    ..To determine the sensitivity of thyroglobulin (Tg), iodine scanning, and sonography in the diagnosis of cervical recurrence of thyroid cancer...
  53. ncbi Expression of S-100 protein in renal cell neoplasms
    Fan Lin
    Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
    Hum Pathol 37:462-70. 2006
    ..These data indicate that caution should be taken in interpreting an unknown primary with S-100 positivity and cytokeratin negativity. In addition, it suggests that S-100 has a diagnostic value in differentiating oncocytoma from ChRCC...
  54. ncbi TC99m MIBI scintigraphy in well-differentiated thyroid carcinoma
    A K Sehgal
    Department of General Surgery and Nuclear Medicine, Ga-Rankuwa Hospital/MEDUNSA
    Cent Afr J Med 47:97-102. 2001
    ..CONCLUSION: TC99m MIBI scintigraphy can be used in association with Fine Needle Aspiration (FNA) in the pre-operative evaluation of thyroid carcinoma...
  55. ncbi Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytoma
    Kien T Mai
    Division of Anatomical Pathology, Department of Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
    Pathol Int 58:164-8. 2008
    ..The carcinoma often poses differential diagnostic problems with RO and has similar immunohistochemical properties to the common type of PRCC. Cytogenetic and molecular studies have not been performed yet for this variant of RCC...
  56. ncbi Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma
    Bita Geramizadeh
    Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    Indian J Pathol Microbiol 51:167-71. 2008
    ....
  57. ncbi Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms
    Steven S Shen
    Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Mod Pathol 18:933-40. 2005
    ..These results demonstrated high sensitivity and specificity of Ksp-cadherin for distal convoluted tubules, which can be used as adjunct for diagnosis of chromophobe RCC...
  58. ncbi [Nodule diagnosed as follicular patterned lesion: are biomarkers the promise?]
    Janete M Cerutti
    Departamento de Morfologia, Universidade Federal de Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 51:832-42. 2007
    ....
  59. pmc Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
    Vera L Costa
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    BMC Cancer 7:133. 2007
    ..In this study we aimed at defining a quantitative gene promoter methylation panel that might identify the most prevalent types of renal cell tumors...
  60. ncbi KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma
    Huan You Wang
    Robert E Fechner Surgical Pathology Laboratory, Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 29:640-6. 2005
    ..Colloidal iron staining aided in this distinction for the majority of the chromophobe renal cell carcinomas (more than 80% positive) and renal oncocytomas (close to 60% negative)...
  61. ncbi Pax-2 expression in adult renal tumors
    L Daniel
    Department of Pathology, CHU Timone, Marseille, France
    Hum Pathol 32:282-7. 2001
    ..Pax-2 expression in conventional renal cell carcinomas is correlated with the proliferation index and is significantly higher in patients with metastatic disease. HUM PATHOL 32:282-287...
  62. ncbi Glypican-3 is expressed in chromophobe renal cell carcinomas
    Krzysztof Okon
    Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 59:15-20. 2008
    ..The reactivity was particularly evident in chromophobe renal cell carcinomas (32/40). Our findings are of note in cases when GPC3 may be used in differential diagnosis of tumors of uncertain primary location...
  63. ncbi [Immunohistochemical characterisation of the main histologic subtypes of epithelial renal tumours on tissue-microarrays. Study of 310 cases]
    Céline Bazille
    Service d Anatomie Pathologique, Hopital Tenon, 4 rue de la Chine, 75020 Paris
    Ann Pathol 24:395-406. 2004
    ..The objective is to study and validate immunohistochemical phenotypes of these tumours and to evaluate if they are helpful and to define a diagnostic strategy...
  64. ncbi Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling
    Christopher D Hornsby
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Arch Pathol Lab Med 131:1541-6. 2007
    ..Immunohistochemistry is useful for distinguishing chromophobe RCC from other subtypes of renal carcinoma, but no expression marker reliably separates chromophobe RCC from oncocytoma...
  65. ncbi Differential expression of caveolin-1 in renal neoplasms
    Ila Tamaskar
    Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Cancer 110:776-82. 2007
    ..In the current study, the authors used immunohistochemistry to investigate the membranous and cytoplasmic expression of caveolin-1 and its correlation with other pathologic parameters in different subtypes of renal neoplasms...
  66. ncbi Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex
    Mark E Snyder
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 176:2391-5; discussion 2395-6. 2006
    ....
  67. ncbi Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas
    Catherine Cheung
    Department of Medicine, University of Queensland, Brisbane, Queensland, Australia
    Int J Urol 12:17-28. 2005
    ..The purpose of the present paper was to describe the pattern of expression of insulin-like growth factor (IGF-I) and its regulatory binding proteins (IGFBP) in renal cell carcinoma (RCC)...
  68. ncbi ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas
    Kohei Shomori
    Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University, Yonago, Tottori, Japan
    Mod Pathol 20:199-207. 2007
    ....
  69. ncbi Hybrid thyroid carcinoma with a coarse chromatin pattern and nuclear features of papillary thyroid carcinoma
    Kien T Mai
    Department of Laboratory Medicine, The Ottawa Hospital, Ontario, Canada
    Pathol Res Pract 198:253-60. 2002
    ..Likewise, areas of CC are often present in PTC. The presence of these focal areas does not appear to change the clinical behavior of the tumor and therefore does not warrant a change of nomenclature...
  70. ncbi Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms
    Harold J Rothenberg
    Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn 55905, USA
    Arch Pathol Lab Med 127:715-7. 2003
    ..Cytoplasmic yellow bodies are a common and frequent histologic finding in hyalinizing trabecular adenoma of the thyroid gland, a morphologically distinctive neoplasm, and are visible in fine-needle aspiration biopsy of the tumor...
  71. ncbi Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma
    Brian P Adley
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Clin Pathol 126:79-85. 2006
    ..Ksp-cad was present in chromophobe RCCs and oncocytomas at mRNA and protein levels, providing strong evidence that Ksp-cad immunohistochemical analysis cannot be used in differentiating these tumors...
  72. ncbi Human Papillomavirus DNA and P16INK4A are not detected in renal tumors with immunohistochemistry and signal-amplified in situ hybridization in paraffin-embedded tissue
    Anissa Hodges
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Appl Immunohistochem Mol Morphol 14:432-5. 2006
    ..No staining for HPV DNA and P16 was found in any type of renal tumors. Our results support that HPV does not seem to play a role in the development of benign and malignant renal tumors...
  73. ncbi [Follow-up of children and young adults with differentiated thyroid cancer treated with radioiodine]
    M Coronado Poggio
    Servicio de Medicina Nuclear, Hospital Universitario La Paz, Madrid, Spain
    Rev Esp Med Nucl 22:316-26. 2003
    ..In our experience, the use of radioiodine is effective and safe in the follow-up of children and youngs with DTC...
  74. ncbi A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritis
    C L Menendez
    Virchows Arch 450:365-7. 2007
  75. ncbi Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma
    Kim L Wang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 38:239-46. 2007
    ..In contrast, adenomas associated with APKD exhibit distinct morphological and immunohistochemical features and, therefore, may have an entirely different pathogenesis...
  76. ncbi Oncocytic angiomyolipoma of the kidney: a case report
    Maria Sironi
    Department of Pathology, Azienda G Salvini Garbagnate Milanese, Garbagnate Milanese, Italy
    Int J Surg Pathol 11:229-34. 2003
    ..Oncocytic angiomyolipoma lacks the atypical features of the recently described epithelioid variant of angiomyolipoma. None of the reported cases have been associated with tuberous sclerosis...
  77. ncbi Nuclear maspin detection in renal cell tumours: possible diagnostic role and correlation with p53 status
    S Blandamura
    Section of Anatomic Pathology, Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy
    Histopathology 49:274-82. 2006
    ..To investigate the presence of maspin in renal tumours in an attempt to improve our understanding of the underlying mechanism of renal carcinogenesis and for diagnostic purposes...
  78. ncbi Expression of vitamin D3 receptor in kidney tumors
    Wenhua Liu
    Department of Pathology, The University of Chicago Hospitals, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Hum Pathol 37:1268-78. 2006
    ..In addition, the focal and much weaker VDR expression in clear cell RCCs makes VDR valuable in distinguishing clear cell RCC from other types of RCCs...
  79. ncbi Immunohistochemical profile of common epithelial neoplasms arising in the kidney
    Mi Kyung Kim
    Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Appl Immunohistochem Mol Morphol 10:332-8. 2002
    ..Discriminant analysis suggested that CD10/CK7/HCK/PL may be a useful primary immunopanel for distinguishing among CC, PC, CDC, and UC...
  80. ncbi Benign renal neoplasms in adults: cross-sectional imaging findings
    Srinivasa R Prasad
    Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    AJR Am J Roentgenol 190:158-64. 2008
    ..Accurate preoperative characterization facilitates optimal patient management...
  81. ncbi [Diagnosis of the follicular variant of papillary thyroid carcinoma. Significance of immunohistochemistry]
    Serge Guyetant
    Service d Anatomie Pathologique, Hopital Trousseau, CHU, 37044 Tours Cedex 1
    Ann Pathol 23:11-20. 2003
    ..To study the expression of cytokeratin 19 (CK-19), HBME-1 and Ret in follicular-patterned thyroid tumors, and their significance for the diagnosis of the follicular variant of papillary thyroid carcinoma...
  82. ncbi Rapid and sensitive detection of messenger RNA expression for molecular differential diagnosis of renal cell carcinoma
    Guorong Li
    Department of Urology, North Hospital, CHU of Saint Etienne, Saint Etienne, France
    Clin Cancer Res 9:6441-6. 2003
    ..The aim of this study was to develop a practical technique to detect mRNA expression and to validate a panel of mRNA markers for molecular differential diagnosis of renal cell carcinoma (RCC)...
  83. ncbi Alpha-methyl CoA racemase expression in renal cell carcinomas
    Vincent Molinie
    Department of Pathology, Hopital Saint Joseph, 75014 Paris Cedex, France
    Hum Pathol 37:698-703. 2006
    ....
  84. ncbi Characteristics of image-detected solid renal masses: implication for optimal treatment
    Guorong Li
    Department of Urology, North Hospital, Central University Hospital of Saint Etienne, France
    Int J Urol 11:63-7. 2004
    ..Solid renal masses are found increasingly. Further analysis of the characteristics of solid renal masses is useful for optimal treatment...
  85. ncbi Computerized nuclear morphometry and quantitation of angiogenesis in thyroid neoplasms
    N Kavantzas
    Dept of Pathology, School of Medicine, National University of Athens, Greece
    J Exp Clin Cancer Res 21:247-54. 2002
    ..Moreover, our study revealed differences in the angiogenetic profile between medullary and follicular cell carcinomas...
  86. ncbi Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytoma
    Ediberto Garcia
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
    Am J Clin Pathol 125:392-8. 2006
    ..These results strongly suggest that caveolin-1 immunohistochemical analysis is useful for differentiating ChRCC from oncocytoma and is superior to CK7...
  87. ncbi CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study
    Manju L Prasad
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 14:169-75. 2004
    ..CITED1 is preferentially expressed in PTC and may be used as a diagnostic marker of it...
  88. ncbi Growth rates of renal cell carcinoma and oncocytoma under surveillance are similar
    Wendy Siu
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 0330, USA
    Urol Oncol 25:115-9. 2007
    ..Through examining our experience with renal mass surveillance, we hoped to determine factors suggestive of renal cell carcinoma...
  89. ncbi Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus
    Stephen B Fox
    CRUK Tumour Pathology Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Pathol 202:313-20. 2004
    ..It further suggests that cells traffic pKDR depending on the precise KDR tyrosines that are autophosphorylated in a manner that enables receptor activation to result in different functions...
  90. pmc My approach to oncocytic tumours of the thyroid
    S L Asa
    Department of Pathology, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Clin Pathol 57:225-32. 2004
    ....
  91. ncbi [Nephron-sparing surgery. Reproducibility of results, personal cases, and comparison with the international literature]
    Mauro Seveso
    Unità Operativa di Urologia, Istituto Clinico Humanitas, Rozzano, Milano, Italy
    Arch Ital Urol Androl 74:65-8. 2002
    ..Partial nephrectomy is an effective method of treatment for renal cell carcinoma. The aim of this study is to compare our experience with international literature data..
  92. ncbi Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma
    K T Mai
    Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
    Histopathology 52:277-82. 2008
    ..To investigate the reactivity for oestrogen and progesterone receptors (ER and PR) in renal oncocytoma (RO) and chromophobe renal cell carcinoma (CHRCC)...
  93. ncbi Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 233 tumors
    Cord Langner
    Institute of Pathology, University of Graz, Medical School, Auenbruggerplatz 25, 8036, Graz, Austria
    Virchows Arch 444:127-34. 2004
    ..Hence, with respect to differential diagnostic value, Hale's colloidal iron stain and vimentin immunostaining are still the most useful tools in renal tumor pathology...
  94. ncbi Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinoma
    T Dahlman
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Eur J Endocrinol 138:104-12. 1998
    ....
  95. ncbi The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions
    Hidenori Inohara
    Department of Otolaryngology, Osaka University School of Medicine, Suita, Japan
    Acta Otolaryngol 128:1152-8. 2008
    ..MRI can be reserved until FNAC shows the indication for surgical intervention...
  96. ncbi Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroid
    Rebecca S Sippel
    Department of Surgery, University of California San Francisco and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143, USA
    World J Surg 32:702-7. 2008
    ..We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm...
  97. ncbi Small-cell variant of renal oncocytoma with dominating solid growth pattern: a potential diagnostic pitfall
    Gaetano Magro
    Virchows Arch 448:379-80. 2006
  98. ncbi Mitochondrial activities of a cell line derived from thyroid Hürthle cell tumors
    Karmen Stankov
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Unita Operativa di Genetica Medica, Policlinico S Orsola Malpighi, Bologna, Italy
    Thyroid 16:325-31. 2006
    ..We conducted a study on the functional characteristics of mitochondria in an oxyphilic thyroid tumor cell line, which may provide useful clues about Hürthle cell tumors carcinogenesis...
  99. ncbi Metastatic Hürthle cell carcinoma: a unique case report and review of the literature
    Sarah Khan
    Department of Endocrinology and Metabolism, St Vincent s Hospital, New York, New York 10011, USA
    Endocr Pract 11:285-9. 2005
  100. ncbi Hürthle cell tumors: using molecular techniques to define a novel classification system
    Greg Belchetz
    Department of Otolaryngology, Mount Sinai Hospital, 600 University Ave, Suite 401, Toronto, Ontario, Canada M5G 1X5
    Arch Otolaryngol Head Neck Surg 128:237-40. 2002
    ..We hypothesize that such HCPTCs behave in a fashion analogous to other papillary carcinomas, while Hürthle cell carcinomas (HCCs) behave similarly to follicular carcinomas...
  101. ncbi [Kidney oncocytoma: diagnostic and therapeutic approach in the INCMNSZ]
    Carlos Arroyo
    Dirección General, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, DF
    Rev Invest Clin 56:297-303. 2004
    ..Follow up will be greatly modified by the diagnosis of oncocytoma since it displays a benign course. Eight cases are presented here that were treated at our institution with special mention to diagnosis and therapy...

Research Grants4

  1. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
    ..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
  2. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
    ..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
  3. TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  4. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..