Genomes and Genes
Summary: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Publications191 found, 100 shown here
- Renal tumors in the Birt-Hogg-Dubé syndromeChristian P Pavlovich
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute NIH, Bldg 10 Rm 2N212, Bethesda, MD 20892, USA
Am J Surg Pathol 26:1542-52. 2002..Recognition by the pathologist of the unusual renal tumors associated with BHD may assist in the clinical diagnosis of the syndrome...
- C-kit expression in renal oncocytomas and chromophobe renal cell carcinomasLei Huo
Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Hum Pathol 36:262-8. 2005..In contrast, immunohistochemical expression of KIT was not detected in most other types of renal cell tumors evaluated. The differential expression of c- kit in these renal tumors may have diagnostic and therapeutic implications...
- Molecular genetics and histopathologic features of adult distal nephron tumorsThomas J Polascik
Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Urology 60:941-6. 2002
- High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomasMaria V Yusenko
Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
BMC Cancer 9:152. 2009..The diagnosis of benign renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) based on their morphology remains uncertain in several cases...
- Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesisM Jinzaki
Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan
J Comput Assist Tomogr 24:835-42. 2000....
- Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and IIIElena Bonora
Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Italy
Cancer Res 66:6087-96. 2006..UC1 is due to a combined complex I/III defect associated with mtDNA mutations, as proven by the transfer of the defective energetic phenotype with the mitochondrial genome into the cybrids...
- Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patientsWilliam W Mayo-Smith
Department of Diagnostic Imaging, Rhode Island Hospital, Brown Medical School, 593 Eddy St, Providence 02903, USA
AJR Am J Roentgenol 180:1503-8. 2003..The purpose of this study was to describe the treatment techniques and results of 38 consecutive imaging-guided percutaneous radiofrequency ablations of solid renal masses performed in 32 patients...
- Adrenocortical oncocytic tumors: report of 10 cases and review of the literatureMichele Bisceglia
Department of Pathology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo FG, Italy
Int J Surg Pathol 12:231-43. 2004..7 months). The 2 benign tumors have a follow-up of 25 and 30 months, respectively. Diagnostic difficulties are delineated and a complete review of the literature on this topic has also been performed...
- Loss of complex I due to mitochondrial DNA mutations in renal oncocytomaJohannes A Mayr
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria
Clin Cancer Res 14:2270-5. 2008....
- The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesionsGennaro Chiappetta
Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, 80131 Napoli, Italy
J Clin Endocrinol Metab 87:364-9. 2002..In particular, the RET/PTC1 isoform was found in 7 of 12 adenomas and 4 of 7 carcinomas. These results would indicate that RET/PTC is a genetic event common to papillary carcinomas and to Hurthle cell neoplasias...
- Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studiesJ Liu
Section of Cytopathology, Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 93:390-7. 2001..The authors retrospectively studied the cytologic features and ancillary study findings of RO compared with findings in RCCs with eosinophilic granular cytoplasm to evaluate the reliability of FNA-based diagnosis of RO...
- Changing concepts in the management of renal oncocytomaDebby H Chao
Division of Urologic Oncology, Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
Urology 59:635-42. 2002
- A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2F Canzian
Unit of Genetic Cancer Susceptibility, International Agency for Research on Cancer, Lyon, France
Am J Hum Genet 63:1743-8. 1998..These findings suggest that the relatives of patients affected with sporadic NMTC with cell oxyphilia should be carefully investigated...
- Endopeptidase 24.11/CD10 is down-regulated in renal cell cancerB Göhring
Department of Urology, Martin Luther University Halle Wittenberg, Halle, Germany
Int J Mol Med 2:409-14. 1998..Aminopeptidase N (APN) and aminopeptidase A (APA) show attenuated expression in up to one third of clear cell/ chromophilic RCC. Chromophobe RCC and oncocytomas do not express APN, APA, NEP and gamma-glutamyltranspeptidase...
- Metastatic renal oncocytomaJ D Oxley
Department of Cellular Pathology, North Bristol NHS Trust, Southmead Hospital, Westbury on Trym, Bristol, UK
J Clin Pathol 60:720-2. 2007
- Oncocytic tumoursG Tallini
Department of Pathology, Yale New Haven Hospital, CT 06510, USA
Virchows Arch 433:5-12. 1998....
- Defective mitochondrial ATP synthesis in oxyphilic thyroid tumorsF Savagner
INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, 4rue Larrey, F 49033 Angers cedex 01, France
J Clin Endocrinol Metab 86:4920-5. 2001..Adenosine triphosphate synthesis was significantly lower in all the tumors, compared with controls, suggesting that a coupling defect in oxidative phosphorylation may be a cause of mitochondrial hyperplasia in oxyphilic thyroid tumors...
- Hürthle cell carcinoma: a 60-year experienceAlexander Stojadinovic
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Ann Surg Oncol 9:197-203. 2002..The aim of this study was to define the clinical behavior and prognostic indicators of outcome in Hürthle cell cancer (HCC)...
- PGC-1-related coactivator and targets are upregulated in thyroid oncocytomaFrederique Savagner
INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, CHU, Angers, France
Biochem Biophys Res Commun 310:779-84. 2003..However, no mtDNA variant in the D-loop region appeared to be involved in oncocytic development. We conclude that overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma...
- The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 casesC C Pan
Department of Pathology, National Yang Ming University, and Taipei Veterans General Hospital, Taipei, Taiwan
Histopathology 45:452-9. 2004..To demonstrate the diagnostic utility of MOC31, BerEP4, renal cell carcinoma marker (RCC Ma) and CD10 in the classification of RCC and renal oncocytoma, based upon a comprehensive immunohistochemical analysis...
- Mitochondrial activity in XTC.UC1 cells derived from thyroid oncocytomaF Savagner
INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, Faculte de Medecine, Angers, France
Thyroid 11:327-33. 2001..XTC.UC1 cells may therefore offer a useful model for investigating the coordination of the nuclear and mitochondrial genomes, in the context of thyroid tumors...
- Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinomaYao Tseng Chen
Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
Clin Cancer Res 11:6558-66. 2005..Whether these renal tumors can be distinguished by their mRNA expression profile of a few selected genes was examined...
- Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytomaLorena Blanco
Dept of Physiology, Faculty of Medicine and Dentistry, Univ of the Basque Country, P O Box 699, E 48080 Bilbao, Bizkaia, Spain
Am J Physiol Renal Physiol 294:F850-8. 2008..These results may suggest an involvement of several peptidases in the pathophysiology of renal cancer, since they presented different patterns of activity and expression in tumors with different behaviors...
- Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytomaGiuseppe Gasparre
Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Bologna, Italy
Hum Mol Genet 17:986-95. 2008..We hypothesize that functional deficiency of the oxidative phosphorylation CI could create a loop of amplification of mitochondria during cell division, impair substrates oxidation and increase intermediary metabolites availability...
- Mitochondrial complex I is deficient in renal oncocytomasHelene Simonnet
CGMC Center of Molecular and Cell Genetics, Unit 5534 of the CNRS and the University Lyon 1 Claude Bernard, Villeurbanne, France
Carcinogenesis 24:1461-6. 2003..This suggested that oncocytomas are the result of at least two serial modifications altering the mitochondrial respiratory chain...
- Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumorsOlivier Baris
Institut National de la Sante et de la Recherche Medicale, Equipe Mixte INSERM Universitaire 0018, Laboratoire de Biochimie et Biologie Moleculaire, Centre Hospitalier Universitaire, Angers F 49033, France
J Clin Endocrinol Metab 89:994-1005. 2004..On the contrary, the lactate dehydrogenase A gene, involved in anaerobic metabolism, was down-regulated. Our results suggest that, unlike a large number of solid tumors, thyroid oncocytomas produce energy through an aerobic pathway...
- Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytomaAnett Nagy
Laboratory of Molecular Oncology, Department of Urology, Ruprecht Karls University, Heidelberg, Germany
Int J Cancer 109:472-5. 2004..Our data suggest the folliculin gene does not play a role in the tumorigenesis of sporadic chromophobe RCCs and renal oncocytomas...
- Cytokeratins 7 and 20 immunoreactivity in chromophobe renal cell carcinomas and renal oncocytomasSang Ling Wu
Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
Mod Pathol 15:712-7. 2002..Despite the technical and interpretive challenges of Hale's colloidal iron, it is still the most useful stain in differentiating chromophobe renal cell carcinomas from renal oncocytomas...
- Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genesStephen Rohan
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Clin Cancer Res 12:6937-45. 2006..To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes...
- From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissueZhengping Zhuang
Surgical Neurology Branch, NINDS NIH, Bethesda, MD 20892, USA
Int J Oncol 28:103-10. 2006..This new combination of techniques allows not only for sensitive identification of specific protein patterns that correspond to a histological tumor phenotype, but also for identification of specific disease-associated protein targets...
- Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changesA Nagy
Laboratory of Molecular Oncology, Department of Urology, Ruprecht Karls University, Heidelberg, Germany
Histopathology 44:542-6. 2004..To assess the value of genetic analysis in their differential diagnosis we analysed 27 ROs and 21 chromophobe RCCs by microsatellite allelotyping...
- Chromophobe renal cell carcinoma: a comparative study of histological, immunohistochemical and ultrastructural features using high throughput tissue microarrayN A Abrahams
The Cleveland Clinic Foundation, Cleveland, OH, USA
Histopathology 45:593-602. 2004..Electron microscopy was performed, as a diagnostic gold standard, on all of the cases...
- Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 casesRonald A Ghossein
Department of Pathology Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 106:1669-76. 2006..Because to the authors' knowledge most studies do not focus exclusively on the encapsulated Hurthle cell carcinoma (EHC), the current study attempted to identify predictors of recurrence in EHC...
- Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytomaPeter R Mazal
Department of Clinical Pathology, Medical University of Vienna, Austria
Hum Pathol 36:22-8. 2005....
- Adrenocortical oncocytoma: a case report and review of literatureGargah T Tahar
Department of Pediatrics, Charles Nicolle Hospital, Tunis, Tunisia
J Pediatr Surg 43:E1-3. 2008..She had an adrenalectomy. The tumor was small and composed predominantly of oncocytes. No criteria of malignancy were found. A discussion of this case and a review of the literature on this entity are presented...
- Losses of 1p and chromosome 14 in renal oncocytomasLaszlo Fuzesi
Department of Pathology, Georg August Universitat Gottingen, Robert Koch Strabe 40, Postfach 3032, Göttingen D 37075, Germany
Cancer Genet Cytogenet 160:120-5. 2005..In the latter cytogenetic subgroup, monosomy 14 was additionally accompanied by either monosomy 1 in 2 cases or loss of 1p in a third case, providing insights in the cytogenetic evolution of this subgroup...
- Metastatic adrenocortical oncocytoma: a case reportJustin J Juliano
Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH 44195, USA
Urol Oncol 26:198-201. 2008..The first case of metastatic adrenocortical oncocytoma is reported along with an update of the literature. A role for radiotherapy in the palliative setting is demonstrated...
- Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancerJ D McKay
Menzies Center for Population Health Research, Hobart, Tasmania, Australia
J Med Genet 41:407-12. 2004..Familial non-medullary thyroid cancer (fNMTC) is a complex genetic disorder that is more aggressive than its sporadic counterpart. Thus far, three genetic loci have been implicated in susceptibility to fNMTC by linkage analysis...
- Renal oncocytosis presenting in childhood: a case reportTerina S Chen
Department of Pathology and Laboratory Medicine, Rochester, New York 14642, USA
Int J Surg Pathol 11:325-9. 2003..We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients...
- Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridizationMaria M Picken
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
Am J Clin Pathol 129:377-82. 2008..Determining whether such abnormalities are unique to renal oncocytomas or are also present in other tumors requires further studies...
- Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosisOzgur Mete
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Temel Bilimler Binasi, 2 Bodrum, Capa, Istanbul, Turkey
Virchows Arch 447:938-46. 2005..We recommend using CD63 as the best marker of choice for distinguishing ROs from eosinophilic chromophobe RCCs when standard diagnostic criteria are not helpful...
- Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumorsValdemar Máximo
Institute of Molecular Pathology and Immunology, The University of Porto, Porto, Portugal
Am J Pathol 160:1857-65. 2002..Germline polymorphisms of the ATPase 6 gene are associated with the occurrence of mtDNA CD, the hallmark of Hürthle cell tumors...
- Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohistochemical markers for renal tumors derived from gene expression profiling studies using cDNA microarraysAndrew N Young
Department of Pathology, Emory University, Atlanta, Georgia, USA
Am J Surg Pathol 27:199-205. 2003..This work demonstrates that a useful panel of immunohistochemical markers can be derived from differential gene expression profiles determined using cDNA microarrays...
- High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor geneKathryn Farrand
Department of Pathology and Molecular Medicine, Wellington School of Medicine, New Zealand
J Clin Endocrinol Metab 87:4715-21. 2002..These data suggest that a TSG, involved in HCC pathogenesis, is contained within the D17S1308-D17S695 interval. There are several potential candidate TSGs in this region that are worthy of further study...
- Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytomaN Kuroda
First Department of Pathology, Kochi Medical School, Nankoku City, Japan
Appl Immunohistochem Mol Morphol 9:315-8. 2001..In addition, paxillin may be an available marker in distinguishing chromophobe RCCs from conventional or papillary RCCs...
- Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray studyPeter R Mazal
Department of Clinical Pathology, Medical University of Vienna, AKH Vienna, Vienna, Austria
Mod Pathol 18:535-40. 2005..Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading...
- Role of color flow Doppler sonography in pre-operative diagnostics of the thyroid pathologyM Giammanco
Department of Surgical, Anatomical and Oncological Science, University of Palermo, Italy
Minerva Endocrinol 27:1-10. 2002....
- Renal cell carcinoma metastatic to Hurthle cell adenoma of thyroidLian Qian
Division of Surgical Pathology Department of Pathology University of Texas Medical Branch, Galveston, TX 77555 0588, USA
Ann Diagn Pathol 8:305-8. 2004..The possibility of metastatic RCC should always be taken under consideration, especially when nests of clear cells are seen infiltrating into the thyroid parenchyma or neoplasm...
- An immunohistochemical approach to the differential diagnosis of renal tumorsBrian F Skinnider
Department of Pathology, Vancouver General Hospital and University of British Columbia, Canada
Semin Diagn Pathol 22:51-68. 2005....
- Radiology-Pathology Conference: Bilateral renal oncocytomasLewis K Shin
Department of Radiology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
Clin Imaging 28:344-8. 2004..Accurate preoperative diagnosis and differentiation from renal carcinoma is difficult. We report the radiology and pathology of a patient with bilateral renal oncocytomas and review the literature of this rare presentation...
- Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patientsLee R Schachter
Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0001, USA
J Endourol 21:819-23. 2007..This study sought to determine the incidence of the various histologic subtypes of renal cortical tumors according to size in a contemporary series of surgically treated patients...
- Sonography in the diagnosis of cervical recurrence in patients with differentiated thyroid carcinomaPedro Weslley Souza do Rosário
Department of Thyroid, Endocrinology and Metabolism Service of Santa Casa de Belo Horizonte, Minas Gerais, Brazil
J Ultrasound Med 23:915-20; quiz 921-2. 2004..To determine the sensitivity of thyroglobulin (Tg), iodine scanning, and sonography in the diagnosis of cervical recurrence of thyroid cancer...
- Expression of S-100 protein in renal cell neoplasmsFan Lin
Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
Hum Pathol 37:462-70. 2006..These data indicate that caution should be taken in interpreting an unknown primary with S-100 positivity and cytokeratin negativity. In addition, it suggests that S-100 has a diagnostic value in differentiating oncocytoma from ChRCC...
- TC99m MIBI scintigraphy in well-differentiated thyroid carcinomaA K Sehgal
Department of General Surgery and Nuclear Medicine, Ga-Rankuwa Hospital/MEDUNSA
Cent Afr J Med 47:97-102. 2001..CONCLUSION: TC99m MIBI scintigraphy can be used in association with Fine Needle Aspiration (FNA) in the pre-operative evaluation of thyroid carcinoma...
- Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytomaKien T Mai
Division of Anatomical Pathology, Department of Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
Pathol Int 58:164-8. 2008..The carcinoma often poses differential diagnostic problems with RO and has similar immunohistochemical properties to the common type of PRCC. Cytogenetic and molecular studies have not been performed yet for this variant of RCC...
- Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinomaBita Geramizadeh
Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Indian J Pathol Microbiol 51:167-71. 2008....
- Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasmsSteven S Shen
Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA
Mod Pathol 18:933-40. 2005..These results demonstrated high sensitivity and specificity of Ksp-cadherin for distal convoluted tubules, which can be used as adjunct for diagnosis of chromophobe RCC...
- [Nodule diagnosed as follicular patterned lesion: are biomarkers the promise?]Janete M Cerutti
Departamento de Morfologia, Universidade Federal de Sao Paulo, SP, Brazil
Arq Bras Endocrinol Metabol 51:832-42. 2007....
- Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumorsVera L Costa
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
BMC Cancer 7:133. 2007..In this study we aimed at defining a quantitative gene promoter methylation panel that might identify the most prevalent types of renal cell tumors...
- KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinomaHuan You Wang
Robert E Fechner Surgical Pathology Laboratory, Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908 0214, USA
Am J Surg Pathol 29:640-6. 2005..Colloidal iron staining aided in this distinction for the majority of the chromophobe renal cell carcinomas (more than 80% positive) and renal oncocytomas (close to 60% negative)...
- Pax-2 expression in adult renal tumorsL Daniel
Department of Pathology, CHU Timone, Marseille, France
Hum Pathol 32:282-7. 2001..Pax-2 expression in conventional renal cell carcinomas is correlated with the proliferation index and is significantly higher in patients with metastatic disease. HUM PATHOL 32:282-287...
- Glypican-3 is expressed in chromophobe renal cell carcinomasKrzysztof Okon
Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
Pol J Pathol 59:15-20. 2008..The reactivity was particularly evident in chromophobe renal cell carcinomas (32/40). Our findings are of note in cases when GPC3 may be used in differential diagnosis of tumors of uncertain primary location...
- [Immunohistochemical characterisation of the main histologic subtypes of epithelial renal tumours on tissue-microarrays. Study of 310 cases]Céline Bazille
Service d Anatomie Pathologique, Hopital Tenon, 4 rue de la Chine, 75020 Paris
Ann Pathol 24:395-406. 2004..The objective is to study and validate immunohistochemical phenotypes of these tumours and to evaluate if they are helpful and to define a diagnostic strategy...
- Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profilingChristopher D Hornsby
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Arch Pathol Lab Med 131:1541-6. 2007..Immunohistochemistry is useful for distinguishing chromophobe RCC from other subtypes of renal carcinoma, but no expression marker reliably separates chromophobe RCC from oncocytoma...
- Differential expression of caveolin-1 in renal neoplasmsIla Tamaskar
Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
Cancer 110:776-82. 2007..In the current study, the authors used immunohistochemistry to investigate the membranous and cytoplasmic expression of caveolin-1 and its correlation with other pathologic parameters in different subtypes of renal neoplasms...
- Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sexMark E Snyder
Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
J Urol 176:2391-5; discussion 2395-6. 2006....
- Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomasCatherine Cheung
Department of Medicine, University of Queensland, Brisbane, Queensland, Australia
Int J Urol 12:17-28. 2005..The purpose of the present paper was to describe the pattern of expression of insulin-like growth factor (IGF-I) and its regulatory binding proteins (IGFBP) in renal cell carcinoma (RCC)...
- ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomasKohei Shomori
Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University, Yonago, Tottori, Japan
Mod Pathol 20:199-207. 2007....
- Hybrid thyroid carcinoma with a coarse chromatin pattern and nuclear features of papillary thyroid carcinomaKien T Mai
Department of Laboratory Medicine, The Ottawa Hospital, Ontario, Canada
Pathol Res Pract 198:253-60. 2002..Likewise, areas of CC are often present in PTC. The presence of these focal areas does not appear to change the clinical behavior of the tumor and therefore does not warrant a change of nomenclature...
- Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasmsHarold J Rothenberg
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn 55905, USA
Arch Pathol Lab Med 127:715-7. 2003..Cytoplasmic yellow bodies are a common and frequent histologic finding in hyalinizing trabecular adenoma of the thyroid gland, a morphologically distinctive neoplasm, and are visible in fine-needle aspiration biopsy of the tumor...
- Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytomaBrian P Adley
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Clin Pathol 126:79-85. 2006..Ksp-cad was present in chromophobe RCCs and oncocytomas at mRNA and protein levels, providing strong evidence that Ksp-cad immunohistochemical analysis cannot be used in differentiating these tumors...
- Human Papillomavirus DNA and P16INK4A are not detected in renal tumors with immunohistochemistry and signal-amplified in situ hybridization in paraffin-embedded tissueAnissa Hodges
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Appl Immunohistochem Mol Morphol 14:432-5. 2006..No staining for HPV DNA and P16 was found in any type of renal tumors. Our results support that HPV does not seem to play a role in the development of benign and malignant renal tumors...
- [Follow-up of children and young adults with differentiated thyroid cancer treated with radioiodine]M Coronado Poggio
Servicio de Medicina Nuclear, Hospital Universitario La Paz, Madrid, Spain
Rev Esp Med Nucl 22:316-26. 2003..In our experience, the use of radioiodine is effective and safe in the follow-up of children and youngs with DTC...
- A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritisC L Menendez
Virchows Arch 450:365-7. 2007
- Renal papillary adenoma--a putative precursor of papillary renal cell carcinomaKim L Wang
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Hum Pathol 38:239-46. 2007..In contrast, adenomas associated with APKD exhibit distinct morphological and immunohistochemical features and, therefore, may have an entirely different pathogenesis...
- Oncocytic angiomyolipoma of the kidney: a case reportMaria Sironi
Department of Pathology, Azienda G Salvini Garbagnate Milanese, Garbagnate Milanese, Italy
Int J Surg Pathol 11:229-34. 2003..Oncocytic angiomyolipoma lacks the atypical features of the recently described epithelioid variant of angiomyolipoma. None of the reported cases have been associated with tuberous sclerosis...
- Nuclear maspin detection in renal cell tumours: possible diagnostic role and correlation with p53 statusS Blandamura
Section of Anatomic Pathology, Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy
Histopathology 49:274-82. 2006..To investigate the presence of maspin in renal tumours in an attempt to improve our understanding of the underlying mechanism of renal carcinogenesis and for diagnostic purposes...
- Expression of vitamin D3 receptor in kidney tumorsWenhua Liu
Department of Pathology, The University of Chicago Hospitals, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Hum Pathol 37:1268-78. 2006..In addition, the focal and much weaker VDR expression in clear cell RCCs makes VDR valuable in distinguishing clear cell RCC from other types of RCCs...
- Immunohistochemical profile of common epithelial neoplasms arising in the kidneyMi Kyung Kim
Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Appl Immunohistochem Mol Morphol 10:332-8. 2002..Discriminant analysis suggested that CD10/CK7/HCK/PL may be a useful primary immunopanel for distinguishing among CC, PC, CDC, and UC...
- Benign renal neoplasms in adults: cross-sectional imaging findingsSrinivasa R Prasad
Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
AJR Am J Roentgenol 190:158-64. 2008..Accurate preoperative characterization facilitates optimal patient management...
- [Diagnosis of the follicular variant of papillary thyroid carcinoma. Significance of immunohistochemistry]Serge Guyetant
Service d Anatomie Pathologique, Hopital Trousseau, CHU, 37044 Tours Cedex 1
Ann Pathol 23:11-20. 2003..To study the expression of cytokeratin 19 (CK-19), HBME-1 and Ret in follicular-patterned thyroid tumors, and their significance for the diagnosis of the follicular variant of papillary thyroid carcinoma...
- Rapid and sensitive detection of messenger RNA expression for molecular differential diagnosis of renal cell carcinomaGuorong Li
Department of Urology, North Hospital, CHU of Saint Etienne, Saint Etienne, France
Clin Cancer Res 9:6441-6. 2003..The aim of this study was to develop a practical technique to detect mRNA expression and to validate a panel of mRNA markers for molecular differential diagnosis of renal cell carcinoma (RCC)...
- Alpha-methyl CoA racemase expression in renal cell carcinomasVincent Molinie
Department of Pathology, Hopital Saint Joseph, 75014 Paris Cedex, France
Hum Pathol 37:698-703. 2006....
- Characteristics of image-detected solid renal masses: implication for optimal treatmentGuorong Li
Department of Urology, North Hospital, Central University Hospital of Saint Etienne, France
Int J Urol 11:63-7. 2004..Solid renal masses are found increasingly. Further analysis of the characteristics of solid renal masses is useful for optimal treatment...
- Computerized nuclear morphometry and quantitation of angiogenesis in thyroid neoplasmsN Kavantzas
Dept of Pathology, School of Medicine, National University of Athens, Greece
J Exp Clin Cancer Res 21:247-54. 2002..Moreover, our study revealed differences in the angiogenetic profile between medullary and follicular cell carcinomas...
- Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytomaEdiberto Garcia
Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
Am J Clin Pathol 125:392-8. 2006..These results strongly suggest that caveolin-1 immunohistochemical analysis is useful for differentiating ChRCC from oncocytoma and is superior to CK7...
- CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based studyManju L Prasad
Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
Thyroid 14:169-75. 2004..CITED1 is preferentially expressed in PTC and may be used as a diagnostic marker of it...
- Growth rates of renal cell carcinoma and oncocytoma under surveillance are similarWendy Siu
Department of Urology, University of Michigan, Ann Arbor, MI 48109 0330, USA
Urol Oncol 25:115-9. 2007..Through examining our experience with renal mass surveillance, we hoped to determine factors suggestive of renal cell carcinoma...
- Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleusStephen B Fox
CRUK Tumour Pathology Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
J Pathol 202:313-20. 2004..It further suggests that cells traffic pKDR depending on the precise KDR tyrosines that are autophosphorylated in a manner that enables receptor activation to result in different functions...
- My approach to oncocytic tumours of the thyroidS L Asa
Department of Pathology, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
J Clin Pathol 57:225-32. 2004....
- [Nephron-sparing surgery. Reproducibility of results, personal cases, and comparison with the international literature]Mauro Seveso
Unità Operativa di Urologia, Istituto Clinico Humanitas, Rozzano, Milano, Italy
Arch Ital Urol Androl 74:65-8. 2002..Partial nephrectomy is an effective method of treatment for renal cell carcinoma. The aim of this study is to compare our experience with international literature data..
- Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinomaK T Mai
Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
Histopathology 52:277-82. 2008..To investigate the reactivity for oestrogen and progesterone receptors (ER and PR) in renal oncocytoma (RO) and chromophobe renal cell carcinoma (CHRCC)...
- Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 233 tumorsCord Langner
Institute of Pathology, University of Graz, Medical School, Auenbruggerplatz 25, 8036, Graz, Austria
Virchows Arch 444:127-34. 2004..Hence, with respect to differential diagnostic value, Hale's colloidal iron stain and vimentin immunostaining are still the most useful tools in renal tumor pathology...
- Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinomaT Dahlman
Department of Internal Medicine, University Hospital, Uppsala, Sweden
Eur J Endocrinol 138:104-12. 1998....
- The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesionsHidenori Inohara
Department of Otolaryngology, Osaka University School of Medicine, Suita, Japan
Acta Otolaryngol 128:1152-8. 2008..MRI can be reserved until FNAC shows the indication for surgical intervention...
- Tumor size predicts malignant potential in Hürthle cell neoplasms of the thyroidRebecca S Sippel
Department of Surgery, University of California San Francisco and the UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, CA 94143, USA
World J Surg 32:702-7. 2008..We sought to determine if the primary tumor size correlated with the risk of malignancy in patients with a preoperative FNA diagnosis of a Hürthle cell neoplasm...
- Small-cell variant of renal oncocytoma with dominating solid growth pattern: a potential diagnostic pitfallGaetano Magro
Virchows Arch 448:379-80. 2006
- Mitochondrial activities of a cell line derived from thyroid Hürthle cell tumorsKarmen Stankov
Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Unita Operativa di Genetica Medica, Policlinico S Orsola Malpighi, Bologna, Italy
Thyroid 16:325-31. 2006..We conducted a study on the functional characteristics of mitochondria in an oxyphilic thyroid tumor cell line, which may provide useful clues about Hürthle cell tumors carcinogenesis...
- Metastatic Hürthle cell carcinoma: a unique case report and review of the literatureSarah Khan
Department of Endocrinology and Metabolism, St Vincent s Hospital, New York, New York 10011, USA
Endocr Pract 11:285-9. 2005
- Hürthle cell tumors: using molecular techniques to define a novel classification systemGreg Belchetz
Department of Otolaryngology, Mount Sinai Hospital, 600 University Ave, Suite 401, Toronto, Ontario, Canada M5G 1X5
Arch Otolaryngol Head Neck Surg 128:237-40. 2002..We hypothesize that such HCPTCs behave in a fashion analogous to other papillary carcinomas, while Hürthle cell carcinomas (HCCs) behave similarly to follicular carcinomas...
- [Kidney oncocytoma: diagnostic and therapeutic approach in the INCMNSZ]Carlos Arroyo
Dirección General, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, DF
Rev Invest Clin 56:297-303. 2004..Follow up will be greatly modified by the diagnosis of oncocytoma since it displays a benign course. Eight cases are presented here that were treated at our institution with special mention to diagnosis and therapy...
- MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDENBenjamin Gelman; Fiscal Year: 2004..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
- HIV and the Proteasome in the Aging Human BrainBenjamin Gelman; Fiscal Year: 2005..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
- TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCHBenjamin Gelman; Fiscal Year: 2007..abstract_text> ..
- Dopamine Systems and Neuropsychiatric Changes in HIV/AIDSBenjamin B Gelman; Fiscal Year: 2010..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..