adenomatous polyps

Summary

Summary: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)

Top Publications

  1. ncbi Celecoxib for the prevention of colorectal adenomatous polyps
    Nadir Arber
    Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    N Engl J Med 355:885-95. 2006
  2. ncbi Diagnostic accuracy of laxative-free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults: a prospective evaluation
    Michael E Zalis
    Department of Imaging, Massachusetts General Hospital, Suite 400A, 25 New Chardon Street, Boston, MA 02114, USA
    Ann Intern Med 156:692-702. 2012
  3. pmc Surveillance guidelines after removal of colorectal adenomatous polyps
    W S Atkin
    Cancer Research UK, Colorectal Cancer Unit, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Gut 51:V6-9. 2002
  4. ncbi Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma
    Xiaoqing Guo
    Department of Endoscopy, The 4th Affiliated Hospital, Hebei Medical University, Hebei, People s Republic of China
    Mol Biol Rep 37:219-25. 2010
  5. ncbi Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy
    Shigeto Mizuno
    Department of Gastroenterology, Kinki University School of Medicine, Nara, Japan
    Int J Cancer 117:1058-9. 2005
  6. ncbi Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males
    Beom Jin Kim
    Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, 140 757, Korea
    Cancer Causes Control 21:939-44. 2010
  7. ncbi Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis
    Yeon Ji Lee
    Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea
    Cancer Causes Control 22:1021-35. 2011
  8. ncbi Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men
    Go Eun Lee
    Department of Preventive Medicine and Health Promotion, Asan Medical Center, Seoul, Korea
    Obesity (Silver Spring) 16:1434-9. 2008
  9. pmc Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps
    Ying Hsiu Su
    Department of Microbiology and Immunology, College of Medicine, Drexel University, Doylestown, Pennsylvania, USA
    Ann N Y Acad Sci 1137:197-206. 2008
  10. ncbi Near-infrared autofluorescence spectroscopy for in vivo identification of hyperplastic and adenomatous polyps in the colon
    Xiaozhuo Shao
    Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Biosens Bioelectron 30:118-22. 2011

Detail Information

Publications226 found, 100 shown here

  1. ncbi Celecoxib for the prevention of colorectal adenomatous polyps
    Nadir Arber
    Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    N Engl J Med 355:885-95. 2006
    Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention.
  2. ncbi Diagnostic accuracy of laxative-free computed tomographic colonography for detection of adenomatous polyps in asymptomatic adults: a prospective evaluation
    Michael E Zalis
    Department of Imaging, Massachusetts General Hospital, Suite 400A, 25 New Chardon Street, Boston, MA 02114, USA
    Ann Intern Med 156:692-702. 2012
    ..Colon screening by optical colonoscopy (OC) or computed tomographic colonography (CTC) requires a laxative bowel preparation, which inhibits screening participation...
  3. pmc Surveillance guidelines after removal of colorectal adenomatous polyps
    W S Atkin
    Cancer Research UK, Colorectal Cancer Unit, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Gut 51:V6-9. 2002
  4. ncbi Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma
    Xiaoqing Guo
    Department of Endoscopy, The 4th Affiliated Hospital, Hebei Medical University, Hebei, People s Republic of China
    Mol Biol Rep 37:219-25. 2010
    ..is to investigate the correlation of the DNMT3B G39179T polymorphism with the susceptibilities of colorectal adenomatous polyps and adenocarcinoma...
  5. ncbi Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy
    Shigeto Mizuno
    Department of Gastroenterology, Kinki University School of Medicine, Nara, Japan
    Int J Cancer 117:1058-9. 2005
    ..A significant increase in the incidence of adenomatous polyps (p < 0.0001) and decrease in normal colonoscopic findings (p < 0...
  6. ncbi Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males
    Beom Jin Kim
    Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, 140 757, Korea
    Cancer Causes Control 21:939-44. 2010
    ..We investigated the clinical usefulness of HbA1c in screening an average-risk group <50 years of age who need colonoscopy for colorectal cancer (CRC) screening...
  7. ncbi Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis
    Yeon Ji Lee
    Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea
    Cancer Causes Control 22:1021-35. 2011
    ..from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent...
  8. ncbi Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men
    Go Eun Lee
    Department of Preventive Medicine and Health Promotion, Asan Medical Center, Seoul, Korea
    Obesity (Silver Spring) 16:1434-9. 2008
    ..logistic regression analysis was used to evaluate the association between BMI and the metabolic syndrome and adenomatous polyps. Compared with men in the 1st quintile of the BMI, the adjusted odds ratio (OR) and 95% confidence interval (..
  9. pmc Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps
    Ying Hsiu Su
    Department of Microbiology and Immunology, College of Medicine, Drexel University, Doylestown, Pennsylvania, USA
    Ann N Y Acad Sci 1137:197-206. 2008
    ..0005), suggesting that inhibitory factors in serum/plasma may be more limiting than in urine. The use and practicality of urine as a source of circulating DNA for cancer detection are discussed...
  10. ncbi Near-infrared autofluorescence spectroscopy for in vivo identification of hyperplastic and adenomatous polyps in the colon
    Xiaozhuo Shao
    Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore
    Biosens Bioelectron 30:118-22. 2011
    ..in the range of 810-1050 nm were acquired from colonic tissues (normal (n=116); hyperplastic (n=48); and adenomatous polyps (n=34)) of 96 patients undergoing colonoscopic screening. Significant differences (p<0...
  11. ncbi Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells
    Kristen L Dennis
    Authors Affiliations Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine Department of Medicine, Knapp Center for Biomedical Discovery Department of Ecology and Evolution, University of Chicago, Chicago Argonne National Laboratory, Argonne, Illinois Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, Arkansas and Institute for Immunology, Technical University Dresden, Dresden, Germany
    Cancer Res 73:5905-13. 2013
    ..Inflammation, local microbe densities, and polyp growth are suppressed by IL-10 derived specifically from T cells and Tregs...
  12. pmc Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps
    Ronald M Summers
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD 20892 1182, USA
    AJR Am J Roentgenol 193:1305-10. 2009
    Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter...
  13. ncbi IL-23/IL-23R: potential mediator of intestinal tumor progression from adenomatous polyps to colorectal carcinoma
    Feng Lan
    Division of Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, People s Republic of China
    Int J Colorectal Dis 26:1511-8. 2011
    ..in intestinal polyps (IP), and in colorectal carcinoma (CRC), and to infer the relationship between the expression patterns of these three molecules and the progress of intestinal tumors from adenomatous polyps to colorectal cancer.
  14. ncbi Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse
    S R Ritland
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA
    Clin Cancer Res 5:855-63. 1999
    ....
  15. ncbi Promoting early detection tests for colorectal carcinoma and adenomatous polyps: a framework for action: the strategic plan of the National Colorectal Cancer Roundtable
    Bernard Levin
    Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:1618-28. 2002
    ..with a practical blueprint for increasing the practice of screening for colorectal carcinoma (CRC) and adenomatous polyps over the next decade...
  16. ncbi Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps
    Sang Tae Hwang
    Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea
    J Gastroenterol Hepatol 25:562-7. 2010
    ..Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  17. ncbi Prevalence of clinically important histology in small adenomas
    Lynn F Butterly
    Dartmouth Hitchcock Medical Center, Gastroenterology, Lebanon, New Hampshire 03756, USA
    Clin Gastroenterol Hepatol 4:343-8. 2006
    ..We evaluated the prevalence of advanced histology in small and diminutive adenomas to clarify their clinical importance in terms of malignant potential...
  18. ncbi Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Biometry Research Group, Divisionof Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Intern Med 148:419-26. 2008
    ..Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers...
  19. pmc JC virus T-antigen expression in sporadic adenomatous polyps of the colon
    Woon Tae Jung
    Division of Gastroenterology, Department of Internal Medicine, The Charles A Sammons Cancer Center, and the Baylor Research Institute, Baylor University Medical Center, Dallas, TX 75246, USA
    Cancer 112:1028-36. 2008
    ..The hypothesis that JCV DNA sequences and T-antigen (T-Ag) expression may be present in adenomatous polyps of the colon was tested...
  20. pmc Analysis of mtDNA sequence variants in colorectal adenomatous polyps
    Sharifeh Mehrabi
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA, 30310, USA
    Diagn Pathol 5:66. 2010
    Colorectal tumors mostly arise from sporadic adenomatous polyps. Polyps are defined as a mass of cells that protrudes into the lumen of the colon...
  21. ncbi NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Oncogene 20:819-27. 2001
    ..In the case of NF-kappaB this coincides with the cellular localisation of COX-2. These results support evidence that NSAIDs may act through effects on stromal cells rather than epithelial cells...
  22. ncbi Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer
    Nigel J Belshaw
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1495-501. 2004
    ..fecal samples were obtained from 32 patients attending for colonoscopy or surgery, who were found to have adenomatous polyps, colorectal cancer, or no evidence of neoplasia...
  23. ncbi Fruits, vegetables, and adenomatous polyps: the Minnesota Cancer Prevention Research Unit case-control study
    Stephanie A Smith-Warner
    Division of Epidemiology, University of Minnesota, Minneapolis, MN, USA
    Am J Epidemiol 155:1104-13. 2002
    ..with a lower risk of colorectal cancer, this relation is less well established for the precursor lesions, adenomatous polyps. With a case-control design involving adenomatous polyp cases (n = 564), colonoscopy-negative controls who ..
  24. ncbi Colon polyps and cancer
    J H Bond
    Gastroenterology Section 111D, Minneapolis Veterans Affairs Medical Center, One Veterans Drive, University of Minnesota, Minneapolis, MN 55417, USA
    Endoscopy 35:27-35. 2003
    ..Recent studies stress the fact that finding and resecting advanced adenomatous polyps, and thereby preventing cancer, is becoming a primary objective of screening programs...
  25. ncbi Cigarette smoking and adenomatous polyps: a meta-analysis
    Edoardo Botteri
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Gastroenterology 134:388-95. 2008
    Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown...
  26. ncbi COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics
    M H McLean
    GI Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Histopathology 52:806-15. 2008
    ..To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation...
  27. ncbi Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential?
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:1012-8. 2002
    ..Risk factors for hyperplastic and adenomatous polyps were generally similar to those for colorectal cancer...
  28. ncbi Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 163:413-20. 2003
    ..To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies...
  29. ncbi [Mixed neoplasia of the stomach: description of a case of tubular adenoma combined with carcinoid]
    L De Marco
    Unità Operative di Anatomia Patologica, Ospedale Ramazzini di Carpi, via Molinari 2, 41012 Carpi, MO
    Pathologica 95:214-6. 2003
    ..Immunohistochemically, the latter component was positive for chromogranin and synaptophysin. The patient is alive and well 10 months after endoscopical polypectomy...
  30. ncbi The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus
    Ali A Siddiqui
    Department of Internal Medicine, Dallas Veteran s Affairs Medical Center, 4500 S Lancaster Road 111B1, Dallas, TX 75216, USA
    Dig Dis Sci 53:1042-7. 2008
    ..The aim of our study was to determine whether poor control of diabetes mellitus (DM) is associated with increased prevalence of colonic adenomatous polyps (APs), especially those that are advanced .
  31. ncbi The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps
    Mitchell S Cappell
    Division of Gastroenterology, Department of Medicine, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141 3098, USA
    Med Clin North Am 89:1-42, vii. 2005
    ....
  32. ncbi Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 129:464-75. 2005
    ..We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer.
  33. ncbi Clinical practice. Adenomatous polyps of the colon
    Joel S Levine
    University of Colorado School of Medicine, Denver, USA
    N Engl J Med 355:2551-7. 2006
  34. ncbi Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism
    I Chun Tsai
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Int J Cancer 120:1005-12. 2007
    ..CKIdelta/epsilon might upregulate CKIdelta/epsilon activity and hence Wnt signaling and increase the risk of adenomatous polyps and colon cancer...
  35. ncbi Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis
    M W Thompson-Fawcett
    Steve Atanas Stavro Familial Colon Cancer Registry and Department of Surgery, Mt Sinai Hospital, University of Toronto, Canada
    Dis Colon Rectum 44:347-53. 2001
    PURPOSE: The aim of this study was to establish the prevalence of adenomatous polyps in the ileal pouch of patients with familial adenomatous polyposis...
  36. pmc Korean type 2 diabetes patients have multiple adenomatous polyps compared to non-diabetic controls
    Sunghwan Suh
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 26:1196-200. 2011
    ..Those with diabetes had a greater proportion of adenomatous polyps (62.8% vs 53.6%) compared to the control...
  37. ncbi The adenoma prevention with celecoxib and prevention of colorectal sporadic adenomatous polyps trials: stepping stones to progress
    Ernest Hawk
    Cancer Epidemiol Biomarkers Prev 16:185-7. 2007
  38. ncbi Relationship of visceral adipose tissue to recurrence of adenomatous polyps
    David A Sass
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 99:687-93. 2004
    ..The aim of this investigation was to determine whether VAT is associated with recurrence of adenomatous polyps, the precursor to colorectal cancer.
  39. ncbi Accumulation and interactions of beta-carotene and alpha-tocopherol in patients with adenomatous polyps
    F Simone
    Human Nutrition Unit, National Research Institute for Food and Nutrition, Rome, Italy
    Eur J Clin Nutr 56:546-50. 2002
    ..E (VE; alpha-tocopherol) would result in their respective accumulation in normal colonic mucosa and in adenomatous polyps; (2) to determine whether the intake of BC would interfere with the concentration of VE in these target ..
  40. ncbi Small invasive colonic cancer occurring in a hyperplastic polyp
    T Kudo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Endoscopy 36:825-8. 2004
    ..This case was considered to be important because it raises the possibility that nonpolypoid cancer can develop from a hyperplastic polyp...
  41. ncbi [Virtual colonoscopy--and then? Relevance of small colorectal polyps]
    T Rother
    Klinik für Diagnostische Radiologie und Neuroradiologie, Klinikum Augsburg
    Rofo 179:130-6. 2007
    ..Growth speed lies in the range of approx. 0.4 mm in 2 years, but regression can be observed as well. The very few existing growth studies cannot provide reliable information about how quickly these small lesions may turn malignant...
  42. ncbi Sensitivity of immunochemical fecal occult blood test for colorectal flat adenomas
    Hidenori Nakama
    Department of Public Health, Shinshu University School of Medicine, and 2Department of Internal Medicine Hata Central Hospital, Japan
    Hepatogastroenterology 51:1333-6. 2004
    ..To assess the sensitivity of an immunochemical fecal occult blood test for colorectal flat adenomas, and to determine the relation between the size of flat adenomas and the results of this test...
  43. pmc The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk
    Qi Dai
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 86:743-51. 2007
    ..Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to magnesium absorption and homeostasis...
  44. ncbi Attendance at surveillance endoscopy of patients with adenoma or colorectal cancer
    Sanna A Mulder
    Department of Gastroenterology, Ikazia Hospital Rotterdam, The Netherlands
    Scand J Gastroenterol 42:66-71. 2007
    ..It is not known whether this type of passive policy affects the efficacy of surveillance. The aim of this study was to determine the yield of surveillance without active invitation to follow-up endoscopy...
  45. ncbi Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  46. ncbi Prophylactic submucosal saline-adrenaline injection in colonoscopic polypectomy: prospective randomized study
    S Dobrowolski
    Department of General, Gastroenterological and Endocrinological Surgery, Medical University of Gdansk, Ul Kieturakisa 1, 80 742, Gdansk, Poland
    Surg Endosc 18:990-3. 2004
    ..The aim of this study was to establish whether the prophylactic injection of adrenaline-saline solution reduces the risk of postpolypectomy bleeding in colonoscopic polypectomy...
  47. ncbi TGFbeta1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Int J Epidemiol 33:955-61. 2004
    ..A polymorphism in the signal peptide sequence of the TGFbeta1 gene (L10P) has been associated with increased levels of plasma TGFbeta1 in individuals with the P allele...
  48. ncbi Colonic surveillance by CT colonography using axial images only
    John F Bruzzi
    Department of Radiology, Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland
    Eur Radiol 14:763-7. 2004
    ..Using 2D axial images only, CT colonography can be performed as part of the daily CT workload, with a very low rate of referral for unnecessary colonoscopy...
  49. ncbi [High resolution chromoendoscopy in the differential diagnosis of neoplastic and non-neoplastic polyps]
    Marcelo Averbach
    Hospital Sirio Libanes, Sao Paulo, SP, Brazil
    Arq Gastroenterol 40:99-103. 2003
    ..Due to these reasons the use of conventional colonoscopy with chromoscopy has been raised because this produce can reproduce most of the information previously obtained by magnifying colonoscopy...
  50. pmc The interaction of age and hormone replacement therapy on colon adenoma risk
    Harvey J Murff
    Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA
    Cancer Detect Prev 31:161-5. 2007
    ..We re-evaluated this interaction and determined if this interaction may be explained by the longer duration of estrogen use in older, rather than younger, women...
  51. ncbi Inflammation-related gene polymorphisms and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:1126-31. 2006
    ..7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma...
  52. ncbi Safety and efficacy of colonoscopy after myocardial infarction: an analysis of 100 study patients and 100 control patients at two tertiary cardiac referral hospitals
    Mitchell S Cappell
    Division of Gastroenterology, Department of Medicine, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141 3098, USA
    Gastrointest Endosc 60:901-9. 2004
    ..The purpose of this study is to analyze the risks vs. the benefits of colonoscopy soon after myocardial infarction...
  53. ncbi Screening colonoscopy in 40- to 50-year-old first-degree relatives of patients with colorectal cancer is efficient: a controlled multicentre study
    Markus Menges
    Department of Internal Medicine II, Division of Gastroenterology, University of Saarland, Homburg, Germany
    Int J Colorectal Dis 21:301-7. 2006
    ..Our aim was to prospectively define the adenoma prevalence in 40- to 50-year-old first-degree relatives of CRC patients compared to controls...
  54. ncbi Findings at follow-up endoscopies in subjects with suspected colorectal abnormalities: effects of baseline findings and time to follow-up
    Fay H Cafferty
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, England
    Cancer J 13:263-70. 2007
    ..The risk of various outcomes at the second examination is assessed according to findings at the first examination and the interval between examinations...
  55. ncbi Magnifying chromoendoscopy: effective diagnostic tool for screening colonoscopy
    Ralf Kiesslich
    J Gastroenterol Hepatol 22:1700-1. 2007
  56. ncbi [Pathomorphologic diagnostic guidelines for colon polyps]
    Jerzy Trawiński
    Wojskowy Instytut Medyczny w Warszawie, Zakład Patomorfologii Klinicznej CSK MON
    Pol Merkur Lekarski 22:454-6. 2007
    ..The recommended laboratory procedures used in preparing of endoscopy material has been discussed. The role of Pathologists and Gastrologist in proper diagnosis of precancerous and early cancerous changes has been also discussed...
  57. ncbi [Serum concentration of insulin, C-peptide and insulin-like growth factor I in patients with colon adenomas and colorectal cancer]
    Aleksandra Kaczka
    Klinika Chorób Przewodu Pokarmowego UM w Łodzi
    Pol Merkur Lekarski 22:373-5. 2007
    ..The aim of the study was to evaluate the serum concentration of insulin, C-peptide and IGF-I in patients with colon adenomas and colorectal cancer...
  58. ncbi Further validation of magnifying chromocolonoscopy for differentiating colorectal neoplastic polyps in a health screening center
    Fabian Emura
    Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 22:1722-7. 2007
    ..This study aimed to further validate the effectiveness of magnifying chromocolonoscopy in the diagnosis of neoplastic colorectal polyps in a screening center...
  59. ncbi Is serum protein electrophoresis useful in separating the "high risk group" in patients with colonic polyps?
    Danuta Kokocinska
    Independent Clinical Immunodiagnostic Laboratory, Department of General and Coloproctological Surgery of Silesian University of Medicine, Poland
    Neuro Endocrinol Lett 28:686-92. 2007
    ..97 polyps were resected with endoscopy in 67 patients. 38 patients (39.17%), those constituting the high risk group, were selected. Included were all polyps with grade II and III of cellular differentiation...
  60. ncbi Endoscopic follow-up of 383 patients with colorectal adenoma: an observational study in daily practice
    Daisy Jonkers
    Department of Gastroenterology and Hepatology, University Hospital Maastricht, The Netherlands
    Eur J Cancer Prev 15:202-10. 2006
    ..b>Adenomatous polyps (with high-risk polyps) were detected in 100% (42.6%) of the index endoscopies and in 25.1% (17.4%), 23...
  61. ncbi Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps
    Shuan C Li
    Department of Pathology and Laboratory Medicine, Orlando Regional Healthcare, 1414 Kuhl Ave, Orlando, FL 32806, USA
    Arch Pathol Lab Med 131:440-5. 2007
    ..They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp...
  62. ncbi Colorectal carcinoma: is screening possible?
    L Bonelli
    Unit of Secondary Prevention and Screening, National Institute for Cancer Research, Largo R Benzi 10, I 16132 Genoa, Italy
    Tech Coloproctol 8:s267-72. 2004
    ..Most cancer arises from adenomatous polyps through the adenoma-carcinoma sequence; the natural history of the disease is long: the risk of invasive ..
  63. ncbi Clinical update: postpolypectomy colonoscopy surveillance
    Otto S Lin
    Virginia Mason Medical Center, Seattle, WA 98101, USA
    Lancet 370:1674-6. 2007
  64. ncbi Prospective comparison of air-contrast barium enema and colonoscopy in patients with fecal occult blood: a pilot study
    Don C Rockey
    Liver Center, Duke University Medical Center, Sands Building Room 334, Research Drive, Durham, NC 27710, USA
    Gastrointest Endosc 60:953-8. 2004
    ..Thus, this study compared the sensitivity and the specificity of air-contrast barium enema and colonoscopy for detection of colonic lesions in patients with fecal occult blood...
  65. ncbi Prospective evaluation of screening colonoscopy: who is being screened?
    Brian Bressler
    Division of Gastroenterology, Department of Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Gastrointest Endosc 60:921-6. 2004
    ..The purposes of this prospective study were to determine the degree to which the practice of colon cancer screening by colonoscopy differed among socioeconomic classes and to assess adherence to screening guidelines...
  66. ncbi Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
    Sidney J Winawer
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    CA Cancer J Clin 56:143-59; quiz 184-5. 2006
    b>Adenomatous polyps are the most common neoplastic findings uncovered in people who undergo colorectal screening or have a diagnostic workup for symptoms...
  67. ncbi Colonoscopy for screening and follow up of patients with a family history of colorectal cancer
    M G Tytherleigh
    Royal Berkshire Hospital, Reading, Berkshire, UK
    Colorectal Dis 10:506-11. 2008
    ..To determine the minimum family history of colorectal cancer (CRC), which justifies colonoscopy and to establish whether further colonic assessment is necessary after a negative screening colonoscopy...
  68. ncbi [Precautions for intestinal cancer in the workplace. An initiative for secondary prevention in the BASF joint-stock company]
    S Webendörfer
    Abteilung Arbeitsmedizin und Gesundheitsschutz, BASF Aktiengesellschaft, Ludwigshafen Rhein
    Dtsch Med Wochenschr 129:239-43. 2004
    ..Against this background the department of occupational medicine and health protection of the BASF Aktiengesellschaft initiated a study on the potential prevention of colorectal cancer among the staff at its Ludwigshafen site...
  69. ncbi [Role of chromoendoscopy in colorectal polyps handling]
    F Baldoni
    Hospital Interzonal Gral San Martíri, Servicio de Gastroenterologia, Cátedra de Gastroenterología de Posgrado Universidad Nacional de la Plata La Plata, Argentina
    Acta Gastroenterol Latinoam 33:187-91. 2003
    ....
  70. pmc Colonoscopic screening for colorectal cancer improves quality of life measures: a population-based screening study
    Doug Taupin
    Gastroenterology and Hepatology Unit and Centre for Advances in Epidemiology and Information Technology, The Canberra Hospital, Yamba Drive, Garran, Australian Capital Territory, Australia
    Health Qual Life Outcomes 4:82. 2006
    ..Colon cancer screening is widespread but the quality of life (QOL) consequences are unknown. This study determined the impact of screening colonoscopy on QOL measures in asymptomatic average-risk participants...
  71. doi Screening, surveillance, and primary prevention for colorectal cancer: a review of the recent literature
    Charles J Kahi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastroenterology 135:380-99. 2008
  72. ncbi Evaluation of (pre-)malignant colonic abnormalities: endoscopic validation of FDG-PET findings
    J P Drenth
    Division of Gastroenterology and Hepatology, Department of Medicine, University Medical Center St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Nucl Med 28:1766-9. 2001
    ..In 19 patients FDG bowel uptake was interpreted as non-physiological, and in 18 patients abnormal findings (adenomatous polyps >3 mm or carcinoma) were detected by endoscopy...
  73. ncbi [Importance of coloncontrast enema]
    V Jacobi
    Institut für Diagnostische und Interventionelle Radiologie, Klinikum, Johann Wolfgang Goethe Universitat Frankfurt
    Radiologe 43:113-21. 2003
    ..It is suitable especially for patients, in which the colonoscopic evaluation of the colon was not complete and provides additional morphological informations in many cases...
  74. ncbi [Colonic polyps diagnosis by conventional video colonoscopes and chromoscopy with indigo carmine dye solution]
    Frank Shigueo Nakao
    Arq Gastroenterol 39:86-92. 2002
    ..Aim - To assess usefullness of conventional video colonoscopes and contrast chromoscopy with indigo carmine solution for differential diagnosis of colon polyps...
  75. pmc Expression of Ki-67 and cytokeratin 20 in hyperplastic polyps of the colorectum
    A Davenport
    Department of Histopathology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    J Clin Pathol 56:200-4. 2003
    ....
  76. ncbi Comparison of the clinicopathologic features between flat and polypoid adenoma
    Sang Kil Lee
    Departments of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Scand J Gastroenterol 43:1116-21. 2008
    ..The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger...
  77. ncbi Evaluation of telomerase in the development and progression of colon cancer
    L Boldrini
    Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, 56100 Pisa, Italy
    Int J Mol Med 10:589-92. 2002
    ..Using a PCR-based TRAP assay, we investigated telomerase activity in 8 adenomatous polyps, 9 dysplastic polyps, and in 36 paired cancer-normal mucosa specimens, one liver and one spleen metastasis ..
  78. ncbi Synchronous proximal polyps and cancer in patients with polyps detected at sigmoidoscopy: results of a single, rural-based sigmoidoscopy clinic
    Thomas J McGarrity
    Department of Medicine, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey 17033 0850, USA
    Dig Dis Sci 47:309-16. 2002
    ..Our data emphasize the importance of colonoscopy in all patients with a polyp detected at sigmoidoscopy independent of its size and histology...
  79. ncbi The promise and peril of surrogate end points in cancer research
    Arthur Schatzkin
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7232, USA
    Nat Rev Cancer 2:19-27. 2002
    ..Surrogate end points--markers of preclinical cancer or of imminent recurrence--are therefore an attractive alternative. But how can we be sure that a study with a surrogate outcome gives us the right answer about the true end point?..
  80. doi Do we need to embrace adenoma detection rate as the main quality control parameter during colonoscopy?
    J F Bretagne
    Endoscopy 40:523-8. 2008
  81. ncbi The case for population-based screening for colorectal cancer
    Robert E Schoen
    Division of Gastroenterology, Pennsylvania University Hospital, Pittsburgh 15213 2582, USA
    Nat Rev Cancer 2:65-70. 2002
    ..Fuelled by new research, market opportunities and increased recognition of individual risk, screening for colorectal cancer is becoming a recommended procedure, but controversy about how best to implement widespread screening remains...
  82. ncbi The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 50:1770-3. 2003
    ..In the current study, we examined the immunohistochemical expression of EDG-2 in colorectal mucosa and adenoma, and clarified its relation with the clinicopathological features...
  83. ncbi [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients]
    Se Yong Oh
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Gastroenterol 47:191-7. 2006
    ..The aims of this study were to determine the incidence of colorectal neoplasm and to evaluate the necessity of colonoscopic surveillance in patients with gastric cancer...
  84. ncbi Two cases of colonic adenomatous polyps accompanied by a migrated surgical suture
    Y Araki
    Dept. of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Endoscopy 33:85-7. 2001
    ..The histological diagnosis was adenoma. These two cases constitute the first report of colonic adenomatous polyps accompanied by suture migration.
  85. ncbi Guidelines for surveillance intervals after polypectomy: coping with the evidence
    Thomas F Imperiale
    Ann Intern Med 148:477-9. 2008
  86. pmc Physician reminders to promote surveillance colonoscopy for colorectal adenomas: a randomized controlled trial
    John Z Ayanian
    Division of General Medicine and Primary Care, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Gen Intern Med 23:762-7. 2008
    Most colorectal cancers develop from adenomatous polyps. National guidelines recommend surveillance colonoscopy within 5 years after such polyps are removed.
  87. ncbi Computer-aided tumor detection in endoscopic video using color wavelet features
    Stavros A Karkanis
    Realtime Systems and Image Analysis Group, Department of Informatics and Telecommunications, University of Athens, Greece
    IEEE Trans Inf Technol Biomed 7:141-52. 2003
    ..The performance in the detection of abnormal colonic regions corresponding to adenomatous polyps has been estimated high, reaching 97% specificity and 90% sensitivity.
  88. ncbi Correlation of the morphology and size of colonic polyps with their histology
    Tze Vun Fong
    Section of Gastroenterology, Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
    Chang Gung Med J 26:339-43. 2003
    Colonic adenomatous polyps are premalignant lesions; early recognition and use of a polypectomy for these polyps can reduce the occurrence of colorectal cancer...
  89. ncbi Colonoscopy surveillance after polypectomy and colorectal cancer resection
    Durado D Brooks
    American Cancer Society, Atlanta, Georgia, USA
    Am Fam Physician 77:995-1002. 2008
    ....
  90. ncbi Surveillance after positive and negative colonoscopy examinations: issues, yields, and use
    Robert E Schoen
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 98:1237-46. 2003
    ..Studies that examine the need and the needed timing of subsequent surveillance are essential to containing costs for screening as well as to informing the public better about what endoscopic screening can and cannot accomplish...
  91. ncbi The anatomical distribution of colorectal polyps at colonoscopy
    K Patel
    Perth Teaching Hospital, Endoscopy Group, Perth, Western Australia, Australia
    J Clin Gastroenterol 33:222-5. 2001
    ..The increasing right-sided prevalence of these lesions with age suggests that evaluation of the proximal bowel is particularly important in older people...
  92. pmc Familial adenomatous polyposis
    Elizabeth Half
    Familial Cancer Clinic, Gastroenterology Dept, Meir Hospital, Kfar Saba, Israel
    Orphanet J Rare Dis 4:22. 2009
    ..A less aggressive variant of FAP, attenuated FAP (AFAP), is characterized by fewer colorectal adenomatous polyps (usually 10 to 100), later age of adenoma appearance and a lower cancer risk...
  93. ncbi Gastric atrophy, metaplasia, and dysplasia: a clinical perspective
    Cyrus R Kapadia
    Department of Internal Medicine, Yale University School of Medicine, LMP 1074, P O Box 208030, New Haven, CT 06520 8030, U S A
    J Clin Gastroenterol 36:S29-36; discussion S61-2. 2003
    ..Cancers also may develop less often from gastric adenomatous polyps, which represent dysplastic epithelium arising in a raised lesion...
  94. ncbi [Clinical aspects in polyps of the colon]
    Fernando Barreda B
    Servicio de Gastroenterología del INEN
    Rev Gastroenterol Peru 27:131-47. 2007
    ..The colonics polyps according to their number, size, location, age of presentation and mainly, according to their histology, have the potentiality of malignant degeneration, which makes of a continuous study and pursuit susceptible...
  95. ncbi Clinical significance of small polyps found during screening with flexible sigmoidoscopy
    Francis A Farraye
    Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Massachusetts 02118, USA
    Gastrointest Endosc Clin N Am 12:41-51. 2002
    In deciding how to interpret the significance and management of small distal adenomatous polyps found on FS, one must first decide on the goal of a screening program...
  96. pmc Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer
    R W Burt
    University Medical Center, Salt Lake City, UT 84132
    Bull World Health Organ 68:655-65. 1990
    ..syndrome (GS) are rare dominantly inherited syndromes characterized by hundreds to thousands of colonic adenomatous polyps. Colon cancer occurs at a young age in both diseases unless the colon is removed...
  97. ncbi Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps
    Patrick A Adegboyega
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Arch Pathol Lab Med 126:829-36. 2002
    ..Through their ability to secrete cytokines, chemokines, prostaglandins, growth factors, and matrix components, they are thought to play critical roles in inflammation, growth, repair, and neoplasia...
  98. ncbi From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy
    M S Cappell
    Division of Gastroenterology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Minerva Gastroenterol Dietol 53:351-73. 2007
    ..While colon cancer in an advanced and incurable stage often produces clinical findings, premalignant adenomatous polyps and early, highly curable, colon cancer are often asymptomatic...
  99. ncbi Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics
    James E Allison
    Division of Research, Kaiser Permanente Northern California Region, 2000 Broadway, Oakland, CA 94612 2304, USA
    J Natl Cancer Inst 99:1462-70. 2007
    ..but it has relatively low sensitivity as a single test for detecting advanced colonic neoplasms (cancer and adenomatous polyps > or = 1 cm in diameter)...
  100. ncbi Primary dietary prevention: is the fiber story over?
    Cheryl L Rock
    Department of Family and Preventive Medicine and Cancer Prevention and Control Program, University of California, San Diego, La Jolla 92093 0901, USA
    Recent Results Cancer Res 174:171-7. 2007
    ..or diet modification can affect the risk for adenoma recurrence and growth in individuals with a history of adenomatous polyps. In four of these intervention studies, subjects in the intervention arm were prescribed dietary fiber ..
  101. ncbi Detection of colorectal neoplasms by the highly sensitive hemoglobin-haptoglobin complex in feces
    A Sieg
    Practice of Gastroenterology, Hauptstrasse 45, D 76684 Ostringen, Germany
    Int J Colorectal Dis 14:267-71. 1999
    ..0 microg/g feces, and 78% at 2.5 and 3.0 microg/g feces. The sensitivity for detecting large adenomatous polyps was 54% with hemoglobin, 76% with the hemoglobin-haptoglobin complex at a cutoff point of 1...

Research Grants64

  1. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Colonic adenomatous polyps are common tumors occurring in approximately 50% of Western populations with about 10% risk of malignant progression...
  2. Nanotheranostics for Early Colorectal Cancer Detection and Treatment
    Jeffrey S Souris; Fiscal Year: 2013
    ..the most frequently found early neoplasms during routine CRC screenings of people >50 years of age are adenomatous polyps. While the overwhelming majority of these polyps are not malignant, significant and sustained reductions in ..
  3. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..With proper screening and removal of adenomatous polyps, CRC risk reduction has been very promising...
  4. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..To test this hypothesis we will recruit 150 participants with recently identified adenomatous polyps and conduct a 6-month double blind 3 X 2 factorial randomized controlled trial...
  5. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..COX-2 expression is found in stromal intestinal myofibroblasts (IMFs) in premalignant colorectal adenomatous polyps and there is global activation (alpha smooth muscle actin expression) in these lamina propria stromal cells...
  6. Early life anthropometry, IGF pathway polymorphisms, and colorectal cancer risk
    Esther Wei; Fiscal Year: 2010
    ..Colorectal neoplasia includes colorectal carcinoma and the precursor lesion of adenomatous polyps. Several early-life anthropometric measures were previously collected in the two large Harvard cohort ..
  7. Colorectal Neoplasia in SELECT Participants
    M PETER LANCE; Fiscal Year: 2011
    Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Adenomatous polyps or colorectal adenomas (CRAs) are the benign neoplastic precursors of CRCs, although most CRAs do not progress to CRC and not ..
  8. JC Virus and Human Colorectal Neoplasia
    CLEMENT R BOLAND; Fiscal Year: 2013
    ..We will also test the hypothesis that exposure to JCV in childhood is associated with the appearance of adenomatous polyps in children with familial adenomatous polyposis...
  9. A novel mouse colon cancer model and chemoprevention
    Wei Dai; Fiscal Year: 2010
    ..Whereas ApcMin/+ mice develop many adenomatous polyps generally within the small intestine, BubRl+/-ApcMin/+ compound mutant mice develop significantly more ..
  10. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    ..due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  11. Promoting Colon Cancer Screening Among African Amercians
    Susan M Rawl; Fiscal Year: 2010
    ..be prevented since CRC, when discovered early, is highly treatable and screening that leads to removal of adenomatous polyps decreases CRC incidence by 75% to 90%...
  12. A Cohort Study of Sessile Serrated Polyps and Subsequent Colorectal Neoplasia
    Polly A Newcomb; Fiscal Year: 2013
    ..applicant): Colorectal cancer screening guidelines currently focus on the detection and removal of advanced adenomatous polyps. However, recent evidence implicates an additional group of polyps, sessile serrated polyps (SSPs), as ..
  13. Modulation of junctional signaling by BVES in colorectal carcinoma
    Christopher S Williams; Fiscal Year: 2013
    ..We found decreased expression of BVES in CRC. BVES was underexpressed in adenomatous polyps indicating that loss of expression is an early event, likely implicating BVES in regulating additional pro- ..
  14. Racial Disparity in Colorectal Cancer: Molecular Mechanisms
    ADHIP N MAJUMDAR; Fiscal Year: 2013
    ..as well as CD44+CD166- phenotype isolated from normal appearing mucosa and colonic effluent of AAs with adenomatous polyps will possess greater tumorigenic properties in vitro and in vivo in SCID mice, compared to those from CAs (..
  15. Epithelial-mesenchymal interactions in gut morphogenesis
    Deborah C Rubin; Fiscal Year: 2010
    ..with our observation that aged Epi-/- mice have a significantly increased incidence of small bowel adenomatous polyps, and occasionally develop invasive cancer. The hypotheses are 1...
  16. Biomarkers of Methionine Metabolism and Risk for Colorectal Adenoma
    Martha J Shrubsole; Fiscal Year: 2010
    ..Most of these cancers arise from adenomatous polyps. Factors involved in one-carbon metabolism and aberrations in methylation reactions have been implicated in ..
  17. The LIN28b-Let7 axis in intestinal epithelial biology
    Anil K Rustgi; Fiscal Year: 2013
    ..intestinal homeostasis is disturbed during states of infection, inflammation and malignant transformation (adenomatous polyps, colorectal cancer)...
  18. The Impact of a Targeted CRC Screening Intervention among Latinos in Central PA
    Oralia G Dominic; Fiscal Year: 2013
    ..If adenomatous polyps detected by screening were removed before they transformed into cancers, a decrease in new CRCs and in ..
  19. Using Mouse Endoscopy for Evaluating Colon Cancer
    DANIEL WILLIAM ROSENBERG; Fiscal Year: 2012
    ..a novel combined endoscopic and proteomic method for evaluating precancerous aberrant crypt foci (ACF) and adenomatous polyps. This methodology aims to establish molecular features that predict, and potentially confer, the efficacy of ..
  20. Molecular Phenotype of Polyps in Serrated Polyposis Syndrome
    Curt H Hagedorn; Fiscal Year: 2013
    ..new technologies to define the gene expression phenotype of SSA/Ps, as compared to traditional hyperplastic, adenomatous polyps and controls, will lead to important insights into the neoplastic progression of SSA/Ps, improve the ..
  21. Mitochondrial Genome Analysis to Detect Aggressive Behavior of Premalignant Color
    Felix O Aikhionbare; Fiscal Year: 2013
    ..The optimal management of patients with colorectal adenomatous polyps depends on the accuracy of appropriate staging strategies because patients with similar colorectal ..
  22. STUDY OF REG RECEPTOR-LIGAND BIOLOGY IN GI MUCOSA
    BRIAN KEITH DIECKGRAEFE; Fiscal Year: 2013
    ..as the foundation for this application, have demonstrated that: i) Expression of Reg IV is increased in adenomatous polyps and in CRCs, often to very high levels, ii) Increased expression Reg IV is one of the earliest steps in the ..
  23. Polyphenon E for the Chemoprevention of Colorectal Cancer
    Frank A Sinicrope; Fiscal Year: 2013
    ..Preclinical and human studies support the utility of ACF, putative precursors of human adenomatous polyps, as a surrogate endpoint biomarker (SEB) for chemoprevention trials...
  24. Novel Sulindac Derivatives for Colon Cancer Chemoprevention
    Robert C Reynolds; Fiscal Year: 2013
    ..identify a novel sulindac derivative as a clinical candidate for patients with either familial or sporadic adenomatous polyps who are at high risk of disease progression...
  25. Ginger for Chemoprevention of Colorectal Cancer
    Suzanna Zick; Fiscal Year: 2009
    ..Consequently, alternative methods to screening that prevent the development of adenomatous polyps and their development to CRC is indicated...
  26. Preclinical assay development of a novel Colon Cancer Marker (CCSA-4)
    JACK CLEMENS; Fiscal Year: 2007
    ..The basis for colon cancer development generally involves the evolution of adenomatous polyps to carcinoma...
  27. Molecular and Clinical Approaches to Colon Cancer Precursors
    SEAN VAHRAM TAVTIGIAN; Fiscal Year: 2013
    ..Since APC is mutated in up to 85% of colorectal cancers and adenomatous polyps, improved understanding of the molecular alterations that characterize tumors harboring APC mutations could ..
  28. HIV, Gut Mucosal Turnover and Inflammation, and the Risk of Colorectal Neoplasia
    Ma Somsouk; Fiscal Year: 2013
    ..and endoscopic studies have suggested that the incidence of colorectal cancer (CRC) and its precursor, adenomatous polyps, is elevated in HIV-infected individuals compared with the general population...
  29. GENES FROM THE FAP LOCUS
    Kenneth W Kinzler; Fiscal Year: 2013
    ..collection of lesions including hyperplastic polyps, serrated adenomas, sessile serrated adenomas, small adenomatous polyps and, most importantly, invasive and adjacent non-invasive components (adenomatous and hyperplastic) from the ..
  30. GENETIC PREDISPOSITION TESTING IN COLORECTAL CANCER
    Deborah Schrag; Fiscal Year: 2003
    ..APC mutations in a hospital-based cohort of American and Israeli Ashkenazi Jews with colorectal cancer or adenomatous polyps. By evaluating gene frequency and penetrance, this analysis will assess the extent to which inherited I1307K ..
  31. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..IGF concentrations are associated with colonic epithelial cell proliferation indices in individuals with adenomatous polyps. We propose to measure IGFs in serum that has been collected from 140 participants in the Soy Isoflavone ..
  32. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2006
    ..The first is the use of stool DNA markers of neoplasia to identify subjects with large adenomatous polyps and/or CRC...
  33. Colon Cancer Prevention Program Project Grant
    M Lance; Fiscal Year: 2009
    ..this goal, we seek to develop highly effective intervention strategies to prevent the recurrence of sporadic adenomatous polyps, and to define the fundamental epidemiologic, epigenetic and genetic mechanisms of polyp genesis and ..
  34. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..incident adenomatous polyp patients, and controls were patients with no previous history of adenomatous polyps who underwent colonoscopy and were found to be free of adenomatous polyps...
  35. DNA METHYLATION AND COLORECTAL POLYPS
    Robert Haile; Fiscal Year: 2003
    ..onto an existing sigmoidoscopy-based case-control study of environmental and genetic risk factors for adenomatous polyps of the large bowel that will have 1,000 cases and 1,000 controls, with food frequency and risk factors ..
  36. Critical evaluation of LPCs markers for colorectal cancer
    Yan Xu; Fiscal Year: 2010
    ..In addition, it is important to determine whether LPCs are changed in adenomatous polyps. We propose two aims...
  37. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..We propose to genotype 550 cases with adenomatous polyps, 200 cases with hyperplastic polyps only, and 700 polyp-free controls...
  38. RECTAL MUCOSAL PROLIFERATION INDICES--EFFECTS OF CALCIUM
    John Baron; Fiscal Year: 1992
    ..randomized trial of the effect of nutritional supplementation with calcium on the recurrence of adenomatous polyps of the large bowel...
  39. Studies of a Novel CCK-B/Gastrin Receptor Splice Variant
    MARK HELLMICH; Fiscal Year: 2005
    ..CCK-BRi4sv is expressed in adenomatous polyps and colorectal cancers, but not in nonmalignant colonic mucosa adjacent to the cancer...
  40. Selenium and colorectal adenomas and adenocarcinomas
    Alexandra Connelly; Fiscal Year: 2003
    ..Most colorectal adenocarcinomas arise from benign, neoplastic adenomatous polyps. Because colorectal cancer has an identifiable precursor lesion (adenomatous polyps), a unique opportunity ..
  41. CALCIUM AND COLORECTAL EPITHELIAL CELL PROLIFERATION
    John Potter; Fiscal Year: 1992
    ..natural fluctuation of colonic epithelial cell proliferation in high risk humans with previous colonic adenomatous polyps. This proposed randomized double-blind placebo-controlled clinical trial would address these gaps by having ..
  42. EXPERIMENTAL AND CLINICAL STUDIES IN COLORECTAL CANCER
    Thomas McGarrity; Fiscal Year: 1993
    ..predict the development of metachronous lesions in patients with resected colorectal cancer and premalignant adenomatous polyps will be analyzed...
  43. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    This is a Phase II/lll study to evaluate the effects of exisulind for treatment on duodenal adenomatous polyps and on adenoma and mucosal apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or ..
  45. Novel Methods for Molecular Analysis of Colorectal Polyps
    James Han; Fiscal Year: 2006
    ..shown that cancer fatalities can be dramatically reduced through early detection and removal of premalignant adenomatous polyps by colonoscopy...
  46. Telehealth Intervention for Colorectal Cancer Screening
    Susan Rawl; Fiscal Year: 2003
    First-degree relatives of people who have been diagnosed with colorectal adenomatous polyps (CAP) have a two-fold-increased risk of developing colorectal cancer (CRC)...
  47. MUC1 Vaccine in Patients with Newly Diagnosed Advanced Adenomas
    Michael Pawlita; Fiscal Year: 2013
    MUC1 is overexpressed and hypoglycosylated on premalignant lesions such as adenomatous polyps, and its expression is significantly greater with higher degrees of dysplasia...
  48. Biomathematical Evaluation of Colon Cancer Screening and Prevention
    GEORG E LUEBECK; Fiscal Year: 2013
    ..Because CRC arises predominantly in benign precursors (mainly the adenomatous polyps), which are likely to sojourn for many years before they turn malignant, CRC can be prevented largely ..
  49. GENETIC DETERMINATES OF HUMAN COLON NEOPLASIA
    Georgia Wiesner; Fiscal Year: 2003
    ..which is aimed at establishing a patient-based family resource of kindreds with colon cancer and colon adenomatous polyps in order to identify new genes that cause colon neoplasia. Along with Dr. Robert Elston, co-mentor, Dr...
  50. GROWTH REGULATION OF HUMAN COLONIC NEOPLASMS
    Michael Brattain; Fiscal Year: 1991
    ..The in vitro model system will consist of the types of cells found in normal colon; hyperplastic polyps, adenomatous polyps and carcinomas...
  51. Exisulind for Chemoprevention of Lung Cancer
    Gerold Bepler; Fiscal Year: 2007
    ..class, and it has shown promise in chemoprevention of colorectal carcinoma by reducing the number of size of adenomatous polyps in humans. In animal studies, this agent has resulted in a reduction of carcinogen-induced lung cancer...
  52. Colon Cancer Pathways: Hyperplastic Polyps and Adenomas
    Polly Newcomb; Fiscal Year: 2009
    ..and polyps, we propose to conduct a population based case-control study of hyperplastic polyps, adenomatous polyps, and normal controls...
  53. MULTIRISK FACTOR INTERVENTION FOR COLON POLYP PATIENTS
    Karen Emmons; Fiscal Year: 2001
    ..b>Adenomatous polyps are a highly prevalent and treatable precursor to CRC...
  54. Interval for colon cancer screening by sigmoidoscopy
    Noel Weiss; Fiscal Year: 2002
    ..colorectal cancer (CRC) by sigmoidoscopy results in the identification and removal of pre-cancerous lesions (adenomatous polyps), thus preventing incident cases of cancer...
  55. EVALUATION OF PREDICTORS FOR RECURRENT ADENOMAS
    Wei Zheng; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's Abstract) Most colorectal cancers arise from adenomatous polyps of the large bowel...
  56. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..leading cause of cancer deaths in the United States but is preventable through the removal of precancerous adenomatous polyps. New vessel growth (angiogenesis) is a prerequisite for polyp growth beyond 2-3mm3 and is consequently an ..
  57. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..shown in epidemiologic studies to increase risk of colorectal cancer and its common precursor lesion, adenomatous polyps. The biological mechanism underlying this relationship may involve effects of circulating leptin levels and ..
  58. PHYTOESTROGENS AND COLON EPITHELIUM--A RANDOMIZED TRIAL
    Johanna Lampe; Fiscal Year: 2001
    ..Eligible individuals with a recent history of adenomatous polyps, aged 50- 74, will be randomized (blocking on sex) to an isoflavone-poor soy supplement over a period of 12 ..
  59. Leukotriene Biosynthesis: Inflammation and Cancer
    Frank Fitzpatrick; Fiscal Year: 2004
    ..typified by inflammatory breast cancer and neuroblastoma, or in pre-neoplastic lesions, typified by adenomatous polyps does not involve its somatic mutation or its sequestration by viral oncoproteins...
  60. Tumor Markers and Recurrent Adenomas: A Follow-up Study
    Wei Zheng; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Most colorectal cancers arise from adenomatous polyps, and a large proportion of patients with adenomas will develop recurrent adenomas...
  61. Cohort Study of Biomarkers for Recurrent Adenoma
    Wei Zheng; Fiscal Year: 2001
    DESCRIPTION (Applicant's Description) Most colorectal cancers arise from adenomatous polyps, and a large proportion of adenoma patients will develop new adenomas after their initial polypectomy...
  62. STATISTICAL METHODS FOR CASE CONTROL SURVIVAL DATA
    Emilia Bagiella; Fiscal Year: 2002
    ..methods developed in Aim (1) to analyze survival data from a prevalence case-control sample of patients with adenomatous polyps (adenomas); 3) To develop regression methods for the analysis of prevalence case-control survival data; 4) ..
  63. COLON POLYP DIAGNOSIS BY VOLUME MICROPROBE SPECTROSCOPY
    Robert Nordstrom; Fiscal Year: 1999
    The goal of this research program is the application of optical biopsy techniques to the identification of adenomatous polyps in the colon. Specific optical instrumentation and software will be developed for this task...
  64. METABOLIC EPIDEMIOLOGY OF COLON CANCER
    Bandaru Reddy; Fiscal Year: 1980
    ..the metabolic activity of fecal microflora (above enzyme parameters) in patients with colon cancer and adenomatous polyps to permit an evaluation of these discriminants for colon cancer...