adenoma

Summary

Summary: A benign epithelial tumor with a glandular organization.

Top Publications

  1. ncbi Progressive methylation during the serrated neoplasia pathway of the colorectum
    Seung M Dong
    Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea
    Mod Pathol 18:170-8. 2005
  2. ncbi Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications
    Sylvie Chevillard
    Laboratoire de Cancerologie Experimentale, Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Département du Radiobiologie et Radiopathologie, Fontenay aux Roses, France
    Clin Cancer Res 10:6586-97. 2004
  3. doi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
  4. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
  5. pmc Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    Silvia Fre
    Morphogenesis and Intracellular Signaling, Institut Curie Unité Mixte de Recherche 144 Centre National de la Recherche Scientifique, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 106:6309-14. 2009
  6. doi Transcriptome profile of human colorectal adenomas
    Jacob Sabates-Bellver
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cancer Res 5:1263-75. 2007
  7. ncbi A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Science 247:322-4. 1990
  8. pmc Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    Sergei I Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0723, USA
    Nature 491:254-8. 2012
  9. ncbi Celecoxib for the prevention of colorectal adenomatous polyps
    Nadir Arber
    Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    N Engl J Med 355:885-95. 2006
  10. doi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010

Detail Information

Publications351 found, 100 shown here

  1. ncbi Progressive methylation during the serrated neoplasia pathway of the colorectum
    Seung M Dong
    Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea
    Mod Pathol 18:170-8. 2005
    Serrated adenoma is a recently described entity characterized by having combined architectural features of hyperplastic polyps and classical adenoma...
  2. ncbi Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications
    Sylvie Chevillard
    Laboratoire de Cancerologie Experimentale, Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Département du Radiobiologie et Radiopathologie, Fontenay aux Roses, France
    Clin Cancer Res 10:6586-97. 2004
    ..The purpose of this research was to identify novel genes that can be targeted as diagnostic and clinical markers of differentiated thyroid tumors...
  3. doi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
    ..Even after 30weeks, large adenomas are very rare in these mice. We conclude that stem-cell-specific loss of Apc results in progressively growing neoplasia...
  4. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
    ..We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon...
  5. pmc Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    Silvia Fre
    Morphogenesis and Intracellular Signaling, Institut Curie Unité Mixte de Recherche 144 Centre National de la Recherche Scientifique, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 106:6309-14. 2009
    ..Importantly, our experimental evidence raises the possibility that Notch activation might be an essential initial event triggering colorectal cancer...
  6. doi Transcriptome profile of human colorectal adenomas
    Jacob Sabates-Bellver
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cancer Res 5:1263-75. 2007
    ....
  7. ncbi A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    A R Moser
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    Science 247:322-4. 1990
    ..The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age...
  8. pmc Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    Sergei I Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0723, USA
    Nature 491:254-8. 2012
    ..We propose that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.
  9. ncbi Celecoxib for the prevention of colorectal adenomatous polyps
    Nadir Arber
    Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    N Engl J Med 355:885-95. 2006
    ..Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention...
  10. doi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  11. pmc Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas
    Xiang Jun Shen
    Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill, NC, USA
    Gut Microbes 1:138-47. 2010
    ..We evaluated adherent bacteria in normal colonic mucosa of 21 adenoma and 23 non-adenoma subjects enrolled in a cross sectional study...
  12. ncbi A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
    ..Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel...
  13. ncbi Metabolic syndrome, hyperinsulinemia, and colon cancer: a review
    Edward Giovannucci
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:s836-42. 2007
    ..This evidence includes studies that examined the risk of colon cancer or adenoma in relation to determinants of the metabolic syndrome (obesity, abdominal distribution of adiposity, and physical ..
  14. ncbi Colorectal cancer in mice genetically deficient in the mucin Muc2
    Anna Velcich
    Department of Oncology, Albert Einstein Cancer Center Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
    Science 295:1726-9. 2002
    ..Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer...
  15. ncbi Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
    Durvanei Augusto Maria
    Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo, Brazil
    Oncogene 22:426-32. 2003
    ..pattern was observed in AIR(max) and AIR(min) mice at marker alleles located within a 452-kb pulmonary adenoma susceptibility 1 (Pas1) locus region, thus defining the location of gene candidacy for inflammatory response and ..
  16. doi Efficacy of a nationwide screening colonoscopy program for colorectal cancer
    Christian P Pox
    Department of Medicine, Ruhr Universitat Bochum, Knappschaftskrankenhaus, Bochum, Germany
    Gastroenterology 142:1460-7.e2. 2012
    ..In autumn 2002, colonoscopy was introduced as part of a nationwide cancer screening program in Germany; it was offered to the general population for individuals 55 years of age or older. We collected and analyzed data from this program...
  17. pmc An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using image processing software analysis for Ki67 immunohistochemistry
    Yukari Fujimori
    Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Diagn Pathol 7:59. 2012
    ..The aim of this study was to evaluate the validity of the morphologic characteristics established in Japan by using immunohistochemical staining for Ki-67...
  18. pmc Signaling pathway networks mined from human pituitary adenoma proteomics data
    Xianquan Zhan
    University of Tennessee Health Science Center, Memphis, USA
    BMC Med Genomics 3:13. 2010
    We obtained a series of pituitary adenoma proteomic expression data, including protein-mapping data (111 proteins), comparative proteomic data (56 differentially expressed proteins), and nitroproteomic data (17 nitroproteins)...
  19. pmc Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases
    Jan H M B Stoot
    Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands
    HPB (Oxford) 12:509-22. 2010
    ..However, its actual risk is currently unknown...
  20. ncbi Colonoscopic withdrawal times and adenoma detection during screening colonoscopy
    Robert L Barclay
    Rockford Gastroenterology Associates, IL 61107, USA
    N Engl J Med 355:2533-41. 2006
    ....
  21. ncbi Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
    Zsolt Petko
    Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA
    Clin Cancer Res 11:1203-9. 2005
    ..Notably, improvements in the specificity and sensitivity of the fecal DNA-based assays will be needed to make them clinically useful diagnostic tests for polyps...
  22. doi Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study
    Adrian F Daly
    Department of Endocrinology, Centre Hospitalier Universitaire de Liege, University of Liege, Liege, Belgium
    J Clin Endocrinol Metab 95:E373-83. 2010
    AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases...
  23. doi Update on the serrated pathway to colorectal carcinoma
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Hibbing, MN 55746, USA
    Hum Pathol 42:1-10. 2011
    ..of carcinomas arise along the serrated pathway developing from the precursor lesion known as the sessile serrated adenoma (also referred to as the sessile serrated polyp)...
  24. ncbi Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study
    Maria Pufulete
    Nutrition Food and Health Research Centre, Department of Nutrition and Dietetics, King s College London, United Kingdom
    Gastroenterology 124:1240-8. 2003
    ....
  25. pmc Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor
    O Galamb
    Department of Medicine, Semmelweis University, Budapest, Hungary
    Br J Cancer 102:765-73. 2010
    ..We analysed the gene expression modulatory effect of N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS398) on HT29 cells to be correlated with expression data gained from biopsy samples...
  26. ncbi The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
    Vickie Hanrahan
    Angiogenesis Research Group, Department of Pathology, Christchurch School of Medicine Health Sciences, Christchurch, New Zealand
    J Pathol 200:183-94. 2003
    ..in many tumour types including colorectal carcinoma (CRC), the importance of the newer family members in adenoma, invasive tumour growth, and progression to a metastatic phenotype has been poorly characterized in CRC...
  27. pmc LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs
    Manal R A Al-Kharusi
    Cancer Research UK Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Medical Sciences Building, University Walk, University of Bristol, UK
    Carcinogenesis 34:1150-7. 2013
    ..Wnt signalling, the focus of this study was to investigate whether PGE2 regulated LGR5 expression in colorectal adenoma cells and whether LGR5 was important for tumour cell survival...
  28. ncbi TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression
    Anke H Sillars-Hardebol
    VU University Medical Center, Department of Pathology, De Boelelaan 1117, Amsterdam, The Netherlands
    Gut 61:1568-75. 2012
    Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis...
  29. doi Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 229:579-87. 2013
    ..of microsatellite instability, was observed in one PGA (3%), 12 foveolar-type adenomas (52%), one intestinal-type adenoma (2%) and five adenocarcinomas (7%)...
  30. doi Serrated polyps and colorectal cancer: new pathway to malignancy
    Amy E Noffsinger
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Annu Rev Pathol 4:343-64. 2009
    Until recently, two major forms of colorectal epithelial polyp were recognized: the adenoma and the hyperplastic polyp...
  31. ncbi Telangiectatic adenoma: an entity associated with increased body mass index and inflammation
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 46:140-6. 2007
    ..Serum biomarkers of inflammation were increased in 90% of patients (19 of 22). After surgical resection, inflammatory marker levels returned to normal values in all patients tested...
  32. doi Role of the serrated pathway in colorectal cancer pathogenesis
    Barbara Leggett
    Royal Brisbane and Women s Hospital Research Foundation, Clinical Research Centre and Queensland Institute of Medical Research, Brisbane, Australia
    Gastroenterology 138:2088-100. 2010
    ..Reappraisal of this view was largely driven by increasing recognition of the malignant potential of hyperplastic polyposis...
  33. pmc Characterization of hepatic adenoma and focal nodular hyperplasia with gadoxetic acid
    Kiyarash Mohajer
    Department of Radiology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    J Magn Reson Imaging 36:686-96. 2012
    To characterize imaging features of histologically proven hepatic adenoma (HA) as well as histologically and/or radiologically proven focal nodular hyperplasia (FNH) using delayed hepatobiliary MR imaging with 0.05 mmol/kg gadoxetic acid.
  34. pmc The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy
    Benjamin Lebwohl
    Department of Medicine, Division of Digestive and Liver Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gastrointest Endosc 73:1207-14. 2011
    ..There are no guidelines for the recommended interval to the next examination after colonoscopy with suboptimal bowel preparation...
  35. pmc Study protocol for BeWEL: the impact of a BodyWEight and physicaL activity intervention on adults at risk of developing colorectal adenomas
    Angela M Craigie
    Centre for Research into Cancer Prevention and Screening, University of Dundee, UK
    BMC Public Health 11:184. 2011
    ..These diseases share risk factors related to the metabolic syndrome including large body size, abnormal lipids and markers of insulin resistance indicating common aetiological pathways...
  36. ncbi Colonoscopic screening of average-risk women for colorectal neoplasia
    Philip Schoenfeld
    Division of Gastroenterology, University of Michigan School of Medicine and Veterans Affairs Center for Excellence in Health Services Research, Ann Arbor 48105, USA
    N Engl J Med 352:2061-8. 2005
    ..In a tandem study, we examined the yield of screening colonoscopy in women...
  37. doi Endoscopic endonasal transsphenoidal surgery: surgical results of 228 pituitary adenomas treated in a pituitary center
    Jackson A Gondim
    Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Brazil
    Pituitary 13:68-77. 2010
    ..We reviewed the data of 228 consecutive patients who underwent endonasal transsphenoidal adenoma removal over an 10-year period...
  38. ncbi Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  39. doi Endoscopic endonasal approach for pituitary adenoma: surgical complications in 301 patients
    Jackson A Gondim
    Department of Neurosurgery, General Hospital of Fortaleza, Av Eng Santana Jr 2977 1402, Fortaleza, CE, Brazil
    Pituitary 14:174-83. 2011
    ..Successful endoscopic pituitary surgery requires extensive training in the use of an endoscope and careful planning of the surgery. Additional improvement can be expected with greater experience and new technical developments...
  40. doi The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma
    Marco Losa
    Department of Neurosurgery, Istituto Scientifico San Raffaele, Via Olgettina 60, Milan, Italy
    J Clin Endocrinol Metab 93:2546-52. 2008
    ..Single-session stereotactic radiotherapy (SR) may be a potential adjuvant treatment in acromegaly...
  41. pmc Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression
    Anke H Sillars-Hardebol
    Department of Pathology Tumor Profiling Unit, VU University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands
    Tumour Biol 31:89-96. 2010
    ..indicating that malignant transformation requires other biological alterations than those involved in adenoma formation...
  42. pmc Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
    Ann G Zauber
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    N Engl J Med 366:687-96. 2012
    ..In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer...
  43. doi Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials
    Bernard F Cole
    Department of Mathematics and Statistics, University of Vermont, Burlington, VT 05401, USA
    J Natl Cancer Inst 101:256-66. 2009
    ..A meta-analysis of these trials will provide more precise estimates of the aspirin effect, both overall and in subgroups...
  44. ncbi BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas
    Tsun L Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Res 63:4878-81. 2003
    Colorectal cancer is believed to progress through an adenoma-carcinoma sequence...
  45. pmc MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression
    B Diosdado
    Department of Pathology, VU University Medical Center Amsterdam, Amsterdam 1081HV, The Netherlands
    Br J Cancer 101:707-14. 2009
    ..colorectal tumours, the combination of gain of 8q and 13q is one of the major factors associated with colorectal adenoma to adenocarcinoma progression...
  46. ncbi Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism
    B Moosgaard
    Aarhus Bone and Mineral Research Group Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 63:506-13. 2005
    ..Primary hyperparathyroidism (PHPT) and vitamin D insufficiency are common conditions that can occur in combination. However, low plasma 25-hydroxyvitamin D (25OHD) may also enhance the risk of PHPT or modify disease severity...
  47. ncbi Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    Enrico Flossmann
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 369:1603-13. 2007
    ..However, the delay from the early development of adenoma to presentation with cancer is at least 10 years...
  48. ncbi Pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions: differentiation using MRI
    S H Choi
    Department of Radiology, Seoul National University College of Medicine, Seoul, Republicof Korea
    Clin Radiol 62:453-62. 2007
    To determine the differential magnetic resonance imaging (MRI) features of pituitary adenoma, craniopharyngioma, and Rathke cleft cyst involving both intrasellar and suprasellar regions.
  49. ncbi Colorectal cancer in patients under close colonoscopic surveillance
    Douglas J Robertson
    Section of Gastroenterology, VA Medical Center, White River Junction, Vermont 05009, USA
    Gastroenterology 129:34-41. 2005
    ..We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia.
  50. ncbi The advanced adenoma as the primary target of screening
    Sidney J Winawer
    Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Gastrointest Endosc Clin N Am 12:1-9, v. 2002
    The advanced adenoma bridges benign and malignant states and may be the most valid neoplastic surrogate marker for present and future colorectal cancer risk...
  51. ncbi Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    Johan H van Es
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 435:959-63. 2005
    ..Our data indicate that gamma-secretase inhibitors, developed for Alzheimer's disease, might be of therapeutic benefit in colorectal neoplastic disease...
  52. ncbi Morphologic reappraisal of serrated colorectal polyps
    Emina Torlakovic
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Norway
    Am J Surg Pathol 27:65-81. 2003
    ..quot;hyperplastic polyp" is considered a benign lesion with no malignant potential, whereas "serrated adenoma" is a precursor of adenocarcinoma...
  53. doi A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video)
    Yutaka Saito
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Gastrointest Endosc 72:1217-25. 2010
    ..Endoscopic submucosal dissection (ESD) is accepted as a minimally invasive treatment for early gastric cancer, although it is not widely used in the colorectum because of technical difficulty...
  54. pmc Understanding the potential and challenges of adenoma treatment as a prevention opportunity: insights from the BeWEL formative study
    Martine Stead
    Institute for Social Marketing, Stirling Management School, University of Stirling, Stirling, FK9 4LA, UK
    Prev Med 54:97-103. 2012
    To explore prevention opportunities presented by colorectal adenoma diagnosis and inform engagement strategies for the BeWEL study (body weight and physical activity lifestyle intervention for colorectal cancer screening participants who ..
  55. ncbi Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    Michael J O'Brien
    Department of Pathology, Boston University Medical Center, Boston, MA 02118, USA
    Am J Surg Pathol 30:1491-501. 2006
    ..instability (MSI) status in each of the histologic categories, including end-point carcinomas with residual adenoma, of the serrated polyp neoplasia pathway and the traditional (nonserrated) adenoma-carcinoma sequence...
  56. doi Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results
    Orsolya Galamb
    2nd Department of Medicine, Semmelweis University, Szentkiralyi str 46, 1088 Budapest, Hungary
    Cancer Epidemiol Biomarkers Prev 17:2835-45. 2008
    ..Our aim was to develop diagnostic mRNA expression patterns that may establish the basis of a new molecular biological diagnostic method...
  57. doi Bowel health to better health: a minimal contact lifestyle intervention for people at increased risk of colorectal cancer
    Stephen Caswell
    Division of Medicine, Centre for Public Health Nutrition Research, University of Dundee, Dundee, UK
    Br J Nutr 102:1541-6. 2009
    ..Screened participants, who had undergone colonoscopy and had adenoma(s) removed, were invited to participate in the bowel health to better health (BHBH) programme...
  58. pmc A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    ..signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  59. doi Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study
    Heiko Pohl
    Department of Gastroenterology, VA Medical Center, White River Junction, Vermont, USA
    Gastroenterology 144:74-80.e1. 2013
    Although the adenoma detection rate is used as a measure of colonoscopy quality, there are limited data on the quality of endoscopic resection of detected adenomas...
  60. pmc Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly: a literature review
    Maria Fleseriu
    Department of Neurological Surgery, Northwest Pituitary Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, BTE 472, Portland, OR 97239, USA
    Pituitary 14:184-93. 2011
    ..In 90-95% of patients with acromegaly, the disease is caused by a growth hormone (GH)-secreting pituitary adenoma with elevated GH levels that ultimately induce excessive hepatic secretion of insulin-like growth factor-1 (IGF-1)..
  61. doi Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma
    Thomas Zueger
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Inselspital, Bern University Hospital, and Institute of Social and Preventive Medicine, University of Bern, CH 3010 Bern, Switzerland
    J Clin Endocrinol Metab 97:E1938-42. 2012
    ..Although data in patients with acromegaly revealed a positive association between glucocorticoid dose and mortality, no comparable results exist in patients with nonfunctioning pituitary adenomas (NFPA)...
  62. doi Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications
    Marie Lise Jaffrain-Rea
    Department of Experimental Medicine, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
    Endocr Relat Cancer 16:1029-43. 2009
    ..Overall, IHC is a poorly sensitive tool for the screening of AIP mutations. Data obtained on AHR expression suggest that AHR signalling may be differentially affected according to PA phenotype...
  63. ncbi Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations
    Sakiko Hiraoka
    Department of Gastroenterology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Gastroenterology 131:379-89. 2006
    ..Laterally spreading tumors (LST), characterized by superficial extension along the colonic lumen, have recently been detected by colonoscopy. However, genetic and epigenetic characteristics of these tumors were scarcely reported...
  64. pmc Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes
    Orsolya Galamb
    2nd Department of Medicine, Semmelweis University, Szentkiralyi str 46, Budapest, Hungary
    Cell Oncol 31:19-29. 2009
    As most colorectal cancers (CRC) develop from villous adenomas, studying alterations in gene expression profiles across the colorectal adenoma-dysplasia-carcinoma sequence may yield potential biomarkers of disease progression.
  65. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    ..These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors...
  66. doi Familial SDHA mutation associated with pituitary adenoma and pheochromocytoma/paraganglioma
    Trisha Dwight
    Cancer Genetics, Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    J Clin Endocrinol Metab 98:E1103-8. 2013
    ..Reports of the coexistence of pituitary adenomas and pheochromocytoma/paraganglioma are uncommon. Recently germline mutations in 2 of the genes encoding succinate dehydrogenase, SDHC and SDHD, were associated with pituitary tumors...
  67. pmc Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study
    U Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg 69115, Germany
    Br J Cancer 99:133-5. 2008
    ..Among 1082 participants of screening colonoscopy in Germany, of whom 30% had any adenoma and 10% had an advanced adenoma, the median (interquartile range) tumour M2 PK level in the whole study ..
  68. doi Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates
    David G Hewett
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 72:775-81. 2010
    Failures of adenoma detection diminish the effectiveness of colonoscopy.
  69. doi Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway
    Harvinder S Chahal
    Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 97:E1411-20. 2012
    ..Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP...
  70. doi Comparison of guaiac-based and quantitative immunochemical fecal occult blood testing in a population at average risk undergoing colorectal cancer screening
    Dong Il Park
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    Am J Gastroenterol 105:2017-25. 2010
    ....
  71. pmc Utilization of surveillance colonoscopy in community practice
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Medical Center, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2582, USA
    Gastroenterology 138:73-81. 2010
    The recommended timing of surveillance colonoscopy for individuals with adenomatous polyps is based on adenoma histology, size, and number. The burden and cost of surveillance colonoscopy are significant...
  72. ncbi Pituitary adenoma predisposition caused by germline mutations in the AIP gene
    Outi Vierimaa
    Department of Clinical Genetics, Oulu University Hospital, 90029 Oulu, Finland
    Science 312:1228-30. 2006
    ..germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene in individuals with pituitary adenoma predisposition (PAP)...
  73. ncbi Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa
    W S Chen
    Division of Colorectal Surgery, Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China
    Int J Cancer 83:579-84. 1999
    ..This study identifies a possible role for arg tyrosine kinase in colon carcinogenesis, especially in the transition from adenoma to carcinoma.
  74. pmc Cushing syndrome in pediatrics
    Constantine A Stratakis
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 41:793-803. 2012
    ..Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed...
  75. doi Prevalence of advanced histological features in diminutive and small colon polyps
    Neil Gupta
    Division of Gastroenterology, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri, USA
    Gastrointest Endosc 75:1022-30. 2012
    ..Advanced histological features such as villous histology, high-grade dysplasia, and/or cancer in these polyps could deter adoption of these strategies...
  76. doi Mortality in Cushing's syndrome: a systematic review and meta-analysis
    D Graversen
    Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Aarhus, Denmark
    Eur J Intern Med 23:278-82. 2012
    ..Data on mortality associated with Cushing's disease (CD) and Cushing's syndrome (CS) are scarce...
  77. ncbi The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical 'cure'
    Panagiotis Nomikos
    Department of Neurosurgery, University of Erlangen Nurnberg, Erlangen, Germany
    Eur J Endocrinol 152:379-87. 2005
    ..The aim of this study was to illustrate the present role of transsphenoidal surgery as primary therapy in GH-secreting adenomas, and to compare the results concerning control of disease with previous series using older criteria of cure...
  78. pmc Metabolic syndrome, lifestyle risk factors, and distal colon adenoma: a retrospective cohort study
    Moon Chan Kim
    Department of Family Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682 714, South Korea
    World J Gastroenterol 17:4031-7. 2011
    To investigate relationships between colorectal adenoma incidence, metabolic syndrome (MS) components and lifestyle factors.
  79. ncbi Sonic hedgehog expression in gastric cancer and gastric adenoma
    Sun Young Lee
    Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143 729, Korea
    Oncol Rep 17:1051-5. 2007
    ..001). Shh expression was stronger in gastric adenoma than in the diffuse-type gastric cancer (p<0...
  80. pmc Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas
    Roger Gejman
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:4119-25. 2008
    ..MEG3 is an imprinted gene encoding a novel noncoding RNA that suppresses tumor cell growth. Although highly expressed in the normal human pituitary, it is unknown which of the normal pituitary cell types and pituitary tumors express MEG3...
  81. doi Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trial
    Amit Rastogi
    Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri 64128 2295, USA
    Gut 61:402-8. 2012
    ..The aim of this study was to compare CAC with standard colonoscopy (SC; high-definition white light) for adenoma detection rates.
  82. pmc Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans
    Hassan Ashktorab
    Department of Medicine and Cancer Center, College of Medicine, Howard University, Washington, DC, United States of America
    PLoS ONE 6:e25314. 2011
    ..Consequently, we evaluated serum 25(OH) D levels, vitamin D receptor (VDR) polymorphisms and the methylation status of the tumor suppressor gene dickkopf homolog 1 (DKK1) as risk factors for colon polyp in this population...
  83. ncbi Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    Oliver M Sieber
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    N Engl J Med 348:791-9. 2003
    ..Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene...
  84. pmc Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
    Paraskevi Xekouki
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E357-66. 2012
    ....
  85. doi Wnt and BMP signals control intestinal adenoma cell fates
    Alexandra L Farrall
    Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Int J Cancer 131:2242-52. 2012
    Cellular hierarchies and signals that govern stemness and differentiation of intestinal adenoma cells are not well defined...
  86. doi Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas
    Stefan de Vogel
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 20:1726-35. 2011
    ..However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome...
  87. doi Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group
    Daniel C DeMarco
    Baylor University Medical Center, Dallas, TX 75246, USA
    Gastrointest Endosc 71:542-50. 2010
    ..The Third Eye Retroscope (TER) is a disposable device that is passed through the instrument channel of a standard colonoscope to provide a retrograde view that complements the forward view of the colonoscope during withdrawal...
  88. ncbi Meat, meat cooking methods and preservation, and risk for colorectal adenoma
    Rashmi Sinha
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:8034-41. 2005
    ..We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative ..
  89. doi The risk factors for malignancy in surgically treated patients for Graves' disease, toxic multinodular goiter, and toxic adenoma
    Yasemin Senyurek Giles
    Department of General Surgery, Istanbul Medical Faculty, Istanbul, Turkey
    Surgery 144:1028-36; discussion 1036-7. 2008
    ..The impact of age, gender, and coexisting cold nodules on the frequency of thyroid carcinoma in hyperthyroid patients in an endemic iodine-deficient region was investigated...
  90. doi Salvage therapy with temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases
    Marco Losa
    Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San Raffaele, Universita Vita Salute, Via Olgettina 60, 20132 Milano, Italy
    Eur J Endocrinol 163:843-51. 2010
    The prognosis of either pituitary carcinoma or aggressive pituitary adenoma resistant to standard therapies is poor...
  91. doi Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia
    Joanne M Lane
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park Adelaide, South Australia
    Gastroenterology 139:1918-26. 2010
    ..We investigated whether giving fecal immunochemical tests (FITs) for hemoglobin between surveillance colonoscopies resulted in earlier detection of neoplasia...
  92. doi Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study
    Kohei Fujita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 35:295-304. 2011
    Sessile serrated adenoma (SSA), also referred to as sessile serrated polyp, has been proposed as a precursor lesion to microsatellite unstable carcinoma...
  93. doi Familial isolated pituitary adenoma: evidence for genetic heterogeneity
    Rodrigo A Toledo
    Endocrine Genetics Unit LIM 25, Endocrinology, Hospital das Clinicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil
    Front Horm Res 38:77-86. 2010
    ..in the Aryl hydrocarbon receptor interacting protein (AIP) gene in a subset of familial isolated pituitary adenoma (FIPA) cases has recently expanded our understanding of the pathophysiology of inherited pituitary adenoma ..
  94. ncbi Long-term outcome and mortality after transsphenoidal adenomectomy for acromegaly
    Catherine Beauregard
    Service of Endocrinology, Notre Dame Hospital, CHUM, University of Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 58:86-91. 2003
    ..We therefore studied a group of 103 patients who underwent transsphenoidal adenomectomy for acromegaly between 1970 and 1999 and were followed for one to 30 years...
  95. doi The American College of Gastroenterology Emily Couric Lecture--the adenoma-carcinoma sequence revisited: has the era of genetic tailoring finally arrived?
    Dennis J Ahnen
    Denver Department of Veterans Affairs Medical Center, University of Colorado Denver School of Medicine, Denver, Colorado 80220, USA
    Am J Gastroenterol 106:190-8. 2011
    Colorectal cancer (CRC) remains a common and often lethal disease. The classic adenoma-carcinoma sequence was defined on histologic grounds but over the last 25 years, the molecular basis of this process has been progressively clarified...
  96. ncbi Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Via S Pansini n 5, 801 31 Naples, Italy
    J Clin Endocrinol Metab 87:4872-8. 2002
    ..This finding supports the concept that chronic mild endogenous cortisol excess may have important systemic effects on the human body...
  97. doi A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma
    Tomoaki Kimura
    Department of Gastroenterology, Akita Red Cross Hospital, Akita, Japan
    Am J Gastroenterol 107:460-9. 2012
    ..Consequently, colonoscopic identification of SSAs has important implications for preventing CRCs, but accurate endoscopic diagnosis is often difficult. Our aim was to clarify which endoscopic findings are specific to SSAs...
  98. doi Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status
    Ann I McCormack
    Cancer Genetics Unit, Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, Australia
    Eur J Clin Invest 41:1133-48. 2011
    ..A DNA repair protein, 06-methylguanine-DNA methyltransferase (MGMT) has been suggested as a biomarker to predict response to temozolomide in pituitary tumours...
  99. pmc NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models
    Yan Sun
    Department of Pathology and Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Clin Cancer Res 17:4331-40. 2011
    ..However, the effect of NGAL in colorectal carcinoma (CRC) has not been clearly elucidated. In this study, we investigated the role of NGAL in the tumorigenesis and progression of CRC and evaluated the clinical value of NGAL expression...
  100. pmc Iron homeostasis and distal colorectal adenoma risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    Amanda J Cross
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 4:1465-75. 2011
    ..iron binding capacity (TIBC), and unsaturated iron binding capacity (UIBC) in relation to incident colorectal adenoma in 356 cases and 396 matched polyp-free controls...
  101. doi Long-term outcomes after Gamma Knife radiosurgery for patients with a nonfunctioning pituitary adenoma
    Rupa Gopalan
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
    Neurosurgery 69:284-93. 2011
    ..Nonfunctioning pituitary adenomas recur after microsurgery. Gamma Knife radiosurgery (GKRS) has been used to treat recurrent adenomas...

Research Grants78

  1. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..microRNA assay for screening right and left colon cancer in stool of patients, particularly at the early adenoma stage (e.g...
  2. Nanotheranostics for Early Colorectal Cancer Detection and Treatment
    Jeffrey S Souris; Fiscal Year: 2013
    ..such diversity of origin, most CRCs follow a similar morphological route - evolving from normal mucosa, to adenoma, to highly-dysplastic adenoma, to carcinoma...
  3. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..develops slowly (10- 15 years) through multiple genetic and phenotypic transitions from normal colonic mucosa to adenoma and then to carcinoma...
  4. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..We established a mouse knockout model of pituitary adenoma that causes recruitment of precursors of the Pou1f1 (PIT1) lineage to produce excess thyrotropes, the pituitary ..
  5. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..factors that might influence the efficacy of fish oil supplementation in order to conduct a more definitive adenoma recurrence trial using marine-derived n-3 PUFAs...
  6. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..DNA hypomethylation, create a 'dietary methyl score', and examine the score in relation to colorectal adenoma/cancer risks...
  7. Novel STIM1-dependent cyclic AMP signaling pathway in colonic epithelial function
    Aldebaran M Hofer; Fiscal Year: 2013
    ..in gene expression and cell division that may ultimately disrupt the function of the epithelium, or even elicit adenoma formation...
  8. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..The central HYPOTHESIS of this research proposal is that KLF4 plays an important role in intestinal adenoma formation and in goblet cell formation and maturation...
  9. Dual Modality System for Imaging Colon Cancer in Mice
    Jennifer Kehlet Barton; Fiscal Year: 2013
    ..We will perform four studies: a) How do ACF and gastrointestinal neoplasias progress to adenoma and/or adenocarcinoma? b) Can treatment with [unreadable]-difluoromethylornithine (DFMO) and/or sulindac regress ..
  10. Lipid genotypes, phenotypes, and colorectal adenomas: Elucidating mechanisms
    Polly A Newcomb; Fiscal Year: 2013
    ..In the proposed post-GWAS study, we will evaluate the association between adenoma occurrence, lipid phenotypes, and lipid genotypes...
  11. MODULATION OF INTESTINAL HOMEOSTASIS AND CANCER
    Leonard H Augenlicht; Fiscal Year: 2013
    ..inflammatory response in the intestinal mucosa of 100% of the mice, and evidence for development of dysplasia and adenoma formation...
  12. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2013
    ..2) Identify differentially expressed proteins in type II pneumocytes, the cells from which lung adenoma arise, of NNK-, NNK plus I3C, or I3C-treated A/J mice...
  13. Risk reduction through polyamine inhibition among colorectal carcinoma patients
    JASON ZELL; Fiscal Year: 2012
    ..Patients with the Odd G315A minor-A allele have been shown to have decreased risk of adenoma recurrence compared to those with the major G-allele...
  14. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2013
    ..We propose to test the hypothesis that adherent bacteria (adherent) are linked with elevated risk of colorectal adenoma and that these bacteria modulate the association between diet, inflammation and colorectal adenomas...
  15. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..increased dietary ratios of arachidonic acid to eicosapentanoic acid will have an increased risk of colorectal adenoma and that this increased risk is mediated through pro-inflammatory eicosanoids and increased oxidative stress...
  16. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..test the efficacy of supplemental calcium 1,200 mg/day and/or vitamin D3 1,000 IU/day against sporadic colorectal adenoma recurrence...
  17. Development of a Urine Test for the Early Detection of Colon Cancer
    Wei Song; Fiscal Year: 2012
    ..screening test is needed to enhance the compliance rate and to increase the rate of early detection of advanced adenoma and CRC to improve the prognosis of the disease...
  18. Impact of Family History of Colon Cancer on Adenomas in 40-49 Year Olds
    Philip S Schoenfeld; Fiscal Year: 2012
    ..hypothesize that 40-49 year old individuals with a family history of CRC will have an increased risk of advanced adenoma compared to age-matched controls...
  19. Transporter Trafficking Mechanisms in Infectious Diarrhea
    Pradeep K Dudeja; Fiscal Year: 2013
    ..Intestinal luminal membrane NHE3 (sodium hydrogen exchanger 3) and DRA [Down Regulated in Adenoma, SLC26A3 Cl-/HCO3-(OH-) exchanger] proteins play critical roles in electroneutral NaCl absorption in the human ..
  20. Determination of the role of CBP and p300 mediated Wnt signaling on colonic cells
    Michael Bordonaro; Fiscal Year: 2010
    ..utilizing CRC cell line model systems of initiation and progression: the normal colon cell lines CCD-841CoN, the adenoma line LT97, the primary colon carcinoma cell line SW480, and the lymph node metastasis cell line SW620...
  21. Intervention models for thyroid proliferative disease using a bioactive food comp
    Raj K Tiwari; Fiscal Year: 2013
    ..million people worldwide are affected by thyroid proliferative diseases (TPD), which include goiter, cancer and adenoma. Women are three times more susceptible than men and overall the incidence of thyroid dysfunction occurring in ..
  22. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..Our long-term goal is to understand the mechanisms of origin and progression of null cell adenoma, and develop new strategies of chemoprevention for it...
  23. Early life anthropometry, IGF pathway polymorphisms, and colorectal cancer risk
    Esther Wei; Fiscal Year: 2010
    ..of early life body size at different stages: 1) birthweight (666 colorectal cancer cases, 2735 distal adenoma cases);2) body fatness during childhood (1411 colorectal cancer cases, 4475 distal adenoma cases) and 3) body ..
  24. Mechanisms of NaCl Absorption in the Human Colon
    Pradeep K Dudeja; Fiscal Year: 2013
    ..gene Slc26a3, whose mutations are associated with congenital chloride diarrhea, encodes DRA (Down-Regulated in Adenoma), a protein known to play a critical role in mediating intestinal chloride absorption...
  25. MOLECULAR GENETICS OF LUNG TUMOR PROMOTION IN MICE
    Ming You; Fiscal Year: 2013
    ABSTRACT Genetic linkage studies using various strains of inbred mice have mapped pulmonary adenoma susceptibility (Pas) and pulmonary adenoma resistance (Par) loci [1,2]...
  26. Mechanistic Studies on Lung Cancer Prevention by Tea Polyphenols
    Chung S Yang; Fiscal Year: 2012
    ..b>Adenoma-bearing mice will receive long- or short-term treatment with EGCG...
  27. INFLAMMATION, OBESITY AND RISK OF COLORECTAL ADENOMAS
    Robert S Sandler; Fiscal Year: 2010
    ..Defining environmental and lifestyle factors that favor adenoma formation is integral to improved surveillance and prevention...
  28. Colorectal Neoplasia in SELECT Participants
    M PETER LANCE; Fiscal Year: 2011
    ..CRCs) in SELECT participants is the opportunity to investigate the effects of trial interventions on colorectal adenoma and cancer endpoints in the same (SELECT) study population...
  29. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2013
    ..efficacy of atorvastatin/rosuvastatin and DFMO on the progression of colonic ACF (post-initiation/early stage) or adenoma (progression/late stage) to colon adenocarcinoma formation in rats...
  30. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    ..for patients with FAP, representing a model which may provide insights into the molecular regulation of the adenoma-carcinoma sequence in ordinary intestinal cancer...
  31. DNA methylation markers for early detection of thyroid cancer
    Josena K Stephen; Fiscal Year: 2013
    ..markers that differentiate benign and malignant thyroid nodules, to detect early TC, to improve discrimination of adenoma, papillary thyroid cancer (PTC), and FTC so as to delineate thyroid subtypes in order to improve patient ..
  32. Tissue-Specific Mutagenesis in Rat as an In Vivo Tool for Colon Cancer Gene Disco
    Joseph C Ruiz; Fiscal Year: 2010
    ..endoscopy, thus enabling polyp monitoring and real-time assessment of somatic mutations taking place in a single adenoma, so that gate-keeper mutations can be more accurately discriminated from mutations involved in later stages of ..
  33. Vitamin D Status, Genetic Variation in Vitamin D Signaling and Metabolism, and Ri
    Peter W Jurutka; Fiscal Year: 2013
    ..1) Measure circulating 25(OH)D and 1,25(OH)2D concentrations among participants in clinical trials of colorectal adenoma recurrence, and assess the association between these variables and the odds of adenoma recurrence;2) Genotype ..
  34. Biomarkers of Methionine Metabolism and Risk for Colorectal Adenoma
    Martha J Shrubsole; Fiscal Year: 2010
    ..We hypothesize that a high SAH level and a low SAM: SAH ratio are associated with an increased risk of colorectal adenoma. In this proposed study, we will evaluate these hypotheses by conducting a nested case-control study using plasma ..
  35. Type II 11B-Hydroxysteroid Dehydrogenase and Colorectal Tumorigenesis
    Mingzhi Zhang; Fiscal Year: 2013
    ..the relative importance of 5-LOX, 15-LOX, and COX-2 pathway in 11ssHSD2 inhibition-mediated inhibition of adenoma development...
  36. Selenium and Selenoprotein P Modify Colorectal Tumorigenesis
    Caitlyn W Barrett; Fiscal Year: 2013
    ..nucleotide polymorphisms (SNPs) in the Selenoprotein P gene (SEPP1) are significantly associated with advanced adenoma risk (4)...
  37. Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Linda D Siracusa; Fiscal Year: 2013
    ..identified loci tha modify intestinal tumor number and size, mammary tumor development, and radiation-induced adenoma multiplicity in ApcMin/+ mice, less than a handful of genes have been identified to date...
  38. Regulation of Lipid Droplets and FOXO3 in Intestinal Epithelial Cell Proliferatio
    SUZANA SAVKOVIC; Fiscal Year: 2013
    ..Aim 3. To assess if obesity and a deficiency in Foxo3 (a) exacerbated adenoma progression in DSS/AOM model leading to alterations in regulators of G0-G1 checkpoint and TGs, (b) if adenoma ..
  39. Specialized Program Research Excellence (SPORE) in Gastrointestinal Cancer
    Eugene W Gerner; Fiscal Year: 2012
    ..of this project is to demonstrate that tailoring prevention therapy in high-risk individuals, based on host and adenoma characteristics, will reduce the development of clinically significant colonic IEN...
  40. Nuclear Hormone Receptor in Intestinal Biology
    RAYMOND NELSON DUBOIS; Fiscal Year: 2010
    ..Preliminary data indicates that a PPARd agonist promotes intestinal adenoma growth, increases tumor cell survival and induces angiogenesis...
  41. Mitochondria as a novel biomarker of colorectal adenoma
    Bharat Thyagarajan; Fiscal Year: 2013
    ..that increased circulating concentrations of oxidative stress biomarkers are associated with increased colorectal adenoma risk...
  42. The Effect of Exogenous Insulin Therapy on Colorectal Adenoma Risk among PTS
    Yu Xiao Yang; Fiscal Year: 2013
    ..others have suggested that exogenous insulin therapy may be associated with an increased prevalence of colorectal adenoma. We hypothesize that insulin therapy may increase the risk of advanced adenoma recurrence among type 2 DM ..
  43. HTS to identify small molecules that disrupt Rab GTPase activator and effector pr
    Angela Wandinger Ness; Fiscal Year: 2009
    ..late endocytic trafficking defects have been demonstrated to underlie Charcot-Marie-Tooth type2B disease, thyroid adenoma, Niemann-Pick type C disease, Alzheimer's disease and Down's syndrome...
  44. MECHANISMS LEADING TO ADRENAL ZONATION
    William E Rainey; Fiscal Year: 2012
    ..Most PA cases are caused by nodular hyperplasia or aldosterone-producing adenoma. A disruption in the normal regulation of CYP11B2 expression appears to be an important part of this disease ..
  45. The role of stromal APC haploinsufficiency in colorectal tumorigenesis
    JAMES PETER ROBINSON; Fiscal Year: 2013
    ..Consequently, FAP is an excellent model for the study of colon cancer because each adenoma represents an early step in tumorigenesis...
  46. The Effect of Dietary Fat on Benzo(a)pyrene Induced Colon Cancer in Apc Min Mice
    DEACQUNITA LAQUADE DIGGS; Fiscal Year: 2010
    ..The influence of dietary lipid type, consumption and the BaP dose on adenoma characteristics will be the focus of this aim...
  47. Colon Cancer Chemoprevention and COX-2 Suppression by Ursodeoxycholic Acid
    Sharad Khare; Fiscal Year: 2013
    ..double blind, placebo-controlled trial of Ursodeoxycholic acid (UDCA) to prevent the recurrence of colorectal adenoma was associated with a statistically significant reduction in recurrence of adenomas with high-grade dysplasia...
  48. Association of Telomere Length with Colorectal Cancer and Adenoma
    Aditi Hazra; Fiscal Year: 2010
    ..and bladder cancers, ulcerative colitis and colon cancer;however, no prospective studies of colorectal cancer and adenoma have been published...
  49. Developing a Post-carcinogen Lung Cancer Chemopreventive Agent
    Chengguo Xing; Fiscal Year: 2013
    ..Determine the post-carcinogen chemopreventive efficacy of kava fractions against lung adenoma formation and establish the efficacy of the most chemopreventive fraction to inhibit lung lesion progression to ..
  50. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2009
    ..Accumulated oncogene and tumor suppressor gene (TSG) defects have been argued to underlie adenoma development and progression of some lesions to carcinoma...
  51. Comparative efficacy of water &indigo carmine vs water or air method
    Joseph W Leung; Fiscal Year: 2013
    ..reported that water infusion in lieu of air insufflation (water method) provided a significantly higher overall adenoma detection rate (ADR) and proximal diminutive ADR than the usual method of air insufflation used during scope ..
  52. APC and Retinoids in Zebrafish Enterocyte Development
    David A Jones; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Our long-term goal is to facilitate the development of new preventive measures for colon adenoma formation by understanding the earliest cellular perturbations that follow APC mutation...
  53. Silencing CD44v6 Expression Prevents Intestinal Tumor Growth
    Suniti Misra; Fiscal Year: 2013
    ..a novel nanoparticle delivery system that selectively directs CD44v6shRNA to intestine/colon cells and blocks adenoma formation...
  54. Cost-Effectiveness Analysis of Age-and Gender-Based Colorectal Cancer Screening
    Nan Kong; Fiscal Year: 2013
    ..g., adenoma incidence and progression rates;and 2) Evaluate the comparative effectiveness and cost-effectiveness of ..
  55. Genome-Wide Association Studies of Inherited Predisposition to Lung Cancer
    Ming You; Fiscal Year: 2013
    ..demonstrated by genetic linkage studies using various strains of inbred mice by having mapped several pulmonary adenoma susceptibility (Pas) and pulmonary adenoma resistance (Par) loci...
  56. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric R Fearon; Fiscal Year: 2013
    ..Accumulated oncogene and tumor suppressor gene (TSG) defects underlie adenoma development and progression of some lesions to carcinoma...
  57. Prospective Studies of Colorectal Adenoma
    Andrew Chan; Fiscal Year: 2009
    ..followed cohorts -- the Nurses'Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Adenoma Prevention with Celecoxib (APC) Trial...
  58. Preoperative and follow-up tests for thyroid tumors
    GREGORY JOSEPH RIGGINS; Fiscal Year: 2010
    ..To address this problem, we previously performed gene expression profiling both a follicular thyroid adenoma (FTA), and a follicular thyroid carcinoma (FTC)...
  59. Inflammation and Colorectal Neoplasia
    Andrew T Chan; Fiscal Year: 2013
    ..drugs such as aspirin and cyclooxygenase-2 (COX-2) selective inhibitors reduce the risk of colorectal adenoma among patients with a prior history of colorectal neoplasia...
  60. Rotating Night Shifts, Sleep Duration, and the Risk of Colorectal Adenoma
    Esther Wei; Fiscal Year: 2013
    ..Unlike many cancers, colorectal cancer has a precursor lesion, adenoma, which can be detected and removed during routine screening endoscopy...
  61. Participant beliefs and bias in a randomized controlled trial
    JUDITH R REES; Fiscal Year: 2013
    ..during a large, multi-center, randomized, placebo-controlled trial of calcium and vitamin D in colorectal adenoma chemoprevention...
  62. Genetic analysis of the P13K/Akt pathway in thyroid benign and malignant disease
    Antonio Di Cristofano; Fiscal Year: 2013
    ..disorder, that it crosstalks with estrogen signaling to determine a higher proliferation index and increased adenoma incidence in females, and that it facilitates malignant transformation upon development of cooperating genetic ..
  63. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..this model we also found infiltrating S100A8/A9 positive myeloid progenitor cells in all regions of dysplasia and adenoma in colon...
  64. STEROID SECRETORY MIXTURES OF ADRENAL CORTEX
    EDWARD BIGLIERI; Fiscal Year: 1991
    ..patients who have primary adrenocortical hyperplasia (PAH), but biochemically and physiologically behave like adenoma. In patients with PAH, elevated 18-hydroxycortisol levels seen usually in adenoma patients would likely result in ..
  65. MECHANISMS OF TCDD TOXICITY
    Diane Russell; Fiscal Year: 1990
    ..In rats inoculated with a prolactin-secreting MtTW15 adenoma, increased serum prolactin resulted in a significantly decreased serum T4 concentration similar to the extent of ..
  66. Colon Cancer Prevention Program Project Grant
    M Lance; Fiscal Year: 2009
    ..of the effect of celecoxib, a COX-2 inhibitor, and selenium, a nutritional supplement, and their combination on adenoma recurrence in 1600 participants...
  67. RECTAL MUCOSAL PROLIFERATION INDICES--EFFECTS OF CALCIUM
    John Baron; Fiscal Year: 1992
    ..In addition to adenoma formation, measurement of large bowel mucosa] proliferation has been proposed as a marker of cancer risk and as a ..
  68. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..provided by applicant): The objective of the proposed study is to examine the association between colorectal adenoma and determinants of oxidative stress including dietary habits, serum ferritin (marker of iron intake), biomarkers ..
  69. IGF Signalling, Apoptosis and Adenoma Risk
    PAULINE LUND; Fiscal Year: 2006
    ..Defining mediators and mechanisms which favor the early stages of the colon cancer such as formation of adenoma, is integral to improved surveillance and prevention of colon cancer...
  70. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    ..is a Phase II/lll study to evaluate the effects of exisulind for treatment on duodenal adenomatous polyps and on adenoma and mucosal apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or ..
  71. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..polyps among patients with familial adenomatous polyposis (FAP) and are associated with a lower risk of both adenoma and colorectal cancer...
  72. NUTRITIONAL PREVENTION OF POLYPS IN THE LARGE BOWEL
    Edward Bresnick; Fiscal Year: 1992
    ..The study involves over 850 patients who were enrolled shortly after diagnosis and removal of a large bowel adenoma. They were assigned at random to four treatment groups in a 2x2 factorial design with the test treatments ..
  73. Colon Polyp Surveillance with DNA Analysis of Stool
    Philip Schoenfeld; Fiscal Year: 2003
    ..test, surveillance colonoscopy, then fecal MTAP may offer a safer and more economical approach to colon adenoma surveillance...
  74. PLAGL2 Expression in Emphysema Patient Lungs
    Yih Sheng Yang; Fiscal Year: 2009
    Abstract: Pleomorphic Adenoma Gene Like-2 (PLAGL2) was identified as a transactivator of surfactant protein C (SP-C)...
  75. Molecular profiles of colorectal adenomas by array CGH
    Galen Hostetter; Fiscal Year: 2009
    ..completion of a hypothesis-driven research plan to analyze genomic alteration patterns associated with colorectal adenoma recurrence and high risk adenomas. My primary mentor is Dr...
  76. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial in humans (yet the previously reported observational evidence, although ..
  77. CALCIUM IN THE PREVENTION OF NEOPLASTIC POLYPS
    John Baron; Fiscal Year: 2003
    ..Treatment in the trial ended in December, 1996. Calcium lowered the risk of any recurrent adenoma by 18% (95% CI 0.66-0.98), and reduced the number of adenomas by 25% (95% CI 0.55-0.94)...
  78. Preoperative and follow-up tests for thyroid tumors
    Gregory Riggins; Fiscal Year: 2006
    ..To address this problem, we previously performed gene expression profiling both a follicular thyroid adenoma (FTA), and a follicular thyroid carcinoma (FTC)...