teratoma

Summary

Summary: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They may be solid or cystic and are classified histologically as mature, immature, and malignant. (From Dorland, 27th ed & DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)

Top Publications

  1. ncbi Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel
    Tatyana A Prokhorova
    Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, University Hospital of Odense and Medical Biotechnology Center, University of Southern Denmark, Winsløwparken, Odense, Denmark
    Stem Cells Dev 18:47-54. 2009
  2. ncbi Generation of mouse induced pluripotent stem cells without viral vectors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:949-53. 2008
  3. ncbi Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
    Elayne M Chan
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Biotechnol 27:1033-7. 2009
  4. ncbi In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
    Feng Cao
    Department of Radiology, Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Circulation 113:1005-14. 2006
  5. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
  6. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
  7. pmc Induced pluripotent stem cells generated without viral integration
    Matthias Stadtfeld
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    Science 322:945-9. 2008
  8. ncbi A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells
    Outi Hovatta
    Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Hum Reprod 18:1404-9. 2003
  9. pmc An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 29:829-34. 2011
  10. ncbi In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    Marius Wernig
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 448:318-24. 2007

Detail Information

Publications327 found, 100 shown here

  1. ncbi Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel
    Tatyana A Prokhorova
    Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, University Hospital of Odense and Medical Biotechnology Center, University of Southern Denmark, Winsløwparken, Odense, Denmark
    Stem Cells Dev 18:47-54. 2009
    When implanted into immunodeficient mice, human embryonic stem cells (hESCs) give rise to teratoma, tumor-like formations containing tissues belonging to all three germ layers...
  2. ncbi Generation of mouse induced pluripotent stem cells without viral vectors
    Keisuke Okita
    Center for iPS Cell Research and Application CiRA, Institute for Integrated Cell Material Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:949-53. 2008
    ..The production of virus-free iPS cells, albeit from embryonic fibroblasts, addresses a critical safety concern for potential use of iPS cells in regenerative medicine...
  3. ncbi Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
    Elayne M Chan
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Biotechnol 27:1033-7. 2009
    ..Our data define molecular markers of the fully reprogrammed state and highlight the need for rigorous characterization and standardization of putative iPS cells...
  4. ncbi In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
    Feng Cao
    Department of Radiology, Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Circulation 113:1005-14. 2006
    ..Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities...
  5. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
    ..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
  6. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
    ..These data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture...
  7. pmc Induced pluripotent stem cells generated without viral integration
    Matthias Stadtfeld
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    Science 322:945-9. 2008
    ..Adenoviral reprogramming may provide an improved method for generating and studying patient-specific stem cells and for comparing embryonic stem cells and iPS cells...
  8. ncbi A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells
    Outi Hovatta
    Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Hum Reprod 18:1404-9. 2003
    ....
  9. pmc An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
    Chad Tang
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Biotechnol 29:829-34. 2011
    ..stem cells (hPSCs), including human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is teratoma formation by residual undifferentiated cells...
  10. ncbi In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    Marius Wernig
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 448:318-24. 2007
    ..Our results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells...
  11. ncbi Comparative evaluation of various human feeders for prolonged undifferentiated growth of human embryonic stem cells
    Mark Richards
    Department of Obstetrics and Gynecology, National University of Singapore, Kent Ridge, Singapore
    Stem Cells 21:546-56. 2003
    ..Also, differences in feeder support exist between human cell types and sources. The use of human adult skin feeders is convenient for hES cell support given the ease of obtaining skin biopsies...
  12. ncbi Generation of pluripotent stem cells from adult human testis
    Sabine Conrad
    Institute of Anatomy, Department of Experimental Embryology, Tubingen, Germany
    Nature 456:344-9. 2008
    ....
  13. pmc The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency
    Anthony D Krentz
    Department of Genetics, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:22323-8. 2009
    ..gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma formation. Mutant 129Sv germ cells undergo apparently normal differentiation up to embryonic day 13.5 (E13...
  14. ncbi Colonic-type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma
    Wang L Cheung
    Department of Pathology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pathol Int 58:792-6. 2008
    ..Pathology indicated a colonic-type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma. The adenocarcinoma was predominantly intracystic with focal superficial invasion into the cyst wall but not ..
  15. doi Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos
    Rachel Eiges
    Department of Genetics, Silberman Institute of Life Science, The Hebrew University, Jerusalem 91904, Israel
    Cell Stem Cell 1:568-77. 2007
    ....
  16. ncbi Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies
    Hannes Hentze
    ES Cell International Pte Ltd, 60 Biopolis Street, No 01 03 Genome, Singapore, 138672 Singapore
    Stem Cell Res 2:198-210. 2009
    ..b>Teratoma assays are considered the gold standard for demonstrating differentiation potential of pluripotent hESC and hold ..
  17. ncbi Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation
    Anke Brederlau
    Institute of Anatomy and Cell Biology, Goteborg University, Gothenburg, Sweden
    Stem Cells 24:1433-40. 2006
    ..This indicates that prolonged in vitro differentiation of hESCs is essential for preventing formation of teratomas...
  18. pmc In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation
    Rutger Jan Swijnenburg
    Department of Cardiothoracic Surgery, Division of Cardiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Stem Cells Dev 17:1023-9. 2008
    ..These data show that mESCs do not retain immune-privileged properties in vivo and are subject to immunological rejection as assessed by novel molecular imaging approaches...
  19. pmc Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells
    Takahisa Fujikawa
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Pathol 166:1781-91. 2005
    ..mice, they reversed the hyperglycemic state for approximately 3 weeks, but the rescue failed due to immature teratoma formation...
  20. pmc Effects of cell number on teratoma formation by human embryonic stem cells
    Andrew S Lee
    Department of Radiology, Molecular Imaging Program at Stanford MIPS, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Cell Cycle 8:2608-12. 2009
    b>Teratoma formation is a critical obstacle to safe clinical translation of human embryonic stem (ES) cell-based therapies in the future...
  21. pmc Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma
    Roberta Vitaliani
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 58:594-604. 2005
    ..seizures, memory deficits, decreased level of consciousness, and central hypoventilation associated with ovarian teratoma (OT) and cerebrospinal fluid (CSF) inflammatory abnormalities...
  22. ncbi Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions
    Ignasi Rodríguez-Pizà
    Center for Regenerative Medicine in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain
    Stem Cells 28:36-44. 2010
    ..behavior, expression of pluripotency-associated markers, and pluripotent differentiation ability in vitro and in teratoma assays...
  23. ncbi Tumorigenic development of induced pluripotent stem cells in ischemic mouse brain
    Toru Yamashita
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 20:883-91. 2011
    ..iPS cells in ischemic brain formed teratoma with higher probability (p < 0.05) and larger volume (p < 0.01) compared with those in intact brain...
  24. pmc Classification of human ovarian tumors
    R E Scully
    Department of Pathology, Harvard Medical School, Boston, MA
    Environ Health Perspect 73:15-25. 1987
    ..Using the World Health Organization Histologic Classification of Ovarian Tumors, histologic features for common and rare human ovarian tumors are described and illustrated...
  25. ncbi CA19-9 may have clinical significance in mature cystic teratomas of the ovary
    M Dede
    Department of Obstetrics and Gynecology, Gulhane Military Medical Academy and Medical School, 06018 Etlik Ankara, Turkey
    Int J Gynecol Cancer 16:189-93. 2006
    ..Since levels of CA19-9 and CA125 may be elevated in both benign and malignant conditions, interpretation of these findings must be made in light of the clinical condition of the patient...
  26. ncbi Elevated CA 19-9 levels in mature cystic teratoma of the ovary
    Min Sun Kyung
    Department of Obstetrics and Gynecology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Gangwon Do, Korea
    Int J Biol Markers 24:52-6. 2009
    ..of this study was to evaluate the clinical value of serum tumor markers in patients with ovarian mature cystic teratoma (MCT)...
  27. ncbi Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data
    Sung Bin Park
    Department of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, South Korea
    Arch Gynecol Obstet 275:25-31. 2007
    ..To evaluate the factors including the imaging findings and clinical and laboratory data that were useful for diagnosing mature cystic teratomas with malignant transformation...
  28. pmc Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation
    Jing Jiang
    Group of Epigenetic Reprogramming, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 23:92-106. 2013
    ..Our findings provide the first demonstration that maintaining genomic stability during reprogramming promotes the generation of high quality iPS cells...
  29. ncbi Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera
    M William Lensch
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 1:253-8. 2007
    ..for one type of human-animal chimera experiment: the evaluation of hES cell developmental potency via teratoma formation in immunodeficient mice...
  30. ncbi Effective cryopreservation of human embryonic stem cells by the open pulled straw vitrification method
    B E Reubinoff
    Department of Obstetrics and Gynecology, Goldyn Savad Institute of Gyne Therapy, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel
    Hum Reprod 16:2187-94. 2001
    ..The study aim was to determine whether the open pulled straw (OPS) vitrification method, which is highly effective for the cryopreservation of embryos, might be also efficient for human ES cells...
  31. ncbi Derivation of human embryonic stem cell lines from parthenogenetic blastocysts
    Qingyun Mai
    1Reproductive Medical Center, the First Affiliated Hospital of SUMS University, Guangzhou 210029, China
    Cell Res 17:1008-19. 2007
    ..However, in vivo, only hPES-1 formed teratoma consisting of all three embryonic germ layers (hPES-2 did not)...
  32. ncbi A call to standardize teratoma assays used to define human pluripotent cell lines
    Franz Josef Muller
    Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Stem Cell 6:412-4. 2010
    The teratoma assay is the gold standard for documenting pluripotency of human stem cells. However, reports of new human ESC and iPSC lines vary widely in both methods and analysis of teratoma data...
  33. ncbi iPS cells produce viable mice through tetraploid complementation
    Xiao yang Zhao
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Nature 461:86-90. 2009
    ..We demonstrate the practicality of using iPS cells as useful tools for the characterization of cellular reprogramming and developmental potency, and confirm that iPS cells can attain true pluripotency that is similar to that of ES cells...
  34. pmc Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28
    Ikuo Tomioka
    Central Institute for Experimental Animals, Kanagawa, Japan
    Genes Cells 15:959-69. 2010
    ..Both embryoid body and teratoma formation showed that marmoset iPS cells had the developmental potential to give rise to differentiated ..
  35. pmc BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice
    Matthew S Cook
    Department of Cell Biology, Duke University, Durham, NC, USA
    Dev Biol 328:377-83. 2009
    ..Male mutants on other genetic backgrounds ultimately lose all PGCs with no incidence of teratoma formation...
  36. ncbi Human feeder layers for human embryonic stem cells
    M Amit
    Department of Obstetrics and Gynecology, Rambam Medical Center, Rambam Medical Center, Haifa, Isreal
    Biol Reprod 68:2150-6. 2003
    ....
  37. ncbi Differentiation of human embryonic stem cells after transplantation in immune-deficient mice
    Stefan A Przyborski
    School of Biological and Biomedical Science, University of Durham, South Road, Durham DH1 3LE, UK
    Stem Cells 23:1242-50. 2005
    ....
  38. ncbi The tumorigenicity of human embryonic stem cells
    Barak Blum
    Stem Cells Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Adv Cancer Res 100:133-58. 2008
    ..The problem of HESC-induced teratomas may also impede or prevent future HESC-based therapies. We thus conclude with a survey of approaches to evade HESC-induced tumor formation...
  39. ncbi Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation
    Feng Cao
    The Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5344, USA
    Cloning Stem Cells 9:107-17. 2007
    ..However, teratoma formation occurred in all nude mice after 5 weeks...
  40. ncbi The postischemic environment differentially impacts teratoma or tumor formation after transplantation of human embryonic stem cell-derived neural progenitors
    Christine Seminatore
    INSERM UMR861, Universite Evry Val d Essonne, Evry, France
    Stroke 41:153-9. 2010
    ..Likely linked to the stage of differentiation of the cells at the time of implantation, formation of teratoma/tumors can also be influenced by factors released by the host tissue...
  41. ncbi Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency
    Akitsu Hotta
    Developmental and Stem Cell Biology Program, Toronto, Ontario, Canada
    Nat Methods 6:370-6. 2009
    ..Finally, we used EOS selection to establish Rett syndrome-specific mouse and human iPS cell lines with known mutations in MECP2...
  42. ncbi Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy
    Tanya M Tekautz
    Department of Hematology Oncology, Mail Stop 260, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Clin Oncol 23:1491-9. 2005
    ..To describe clinical features, therapeutic approaches, and prognostic factors in pediatric patients with atypical teratoid/rhabdoid tumors (ATRT) treated at St Jude Children's Research Hospital (SJCRH)...
  43. pmc Generation of induced pluripotent stem cell lines from Tibetan miniature pig
    Miguel A Esteban
    Stem Cell and Cancer Biology Group, Chinese Academy of Sciences Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510663, USA
    J Biol Chem 284:17634-40. 2009
    ..Because porcine physiology closely resembles human, the iPS cells reported here provide an attractive model to study certain human diseases or assess therapeutic applications of iPS in a large animal model...
  44. ncbi Familial testicular cancer and second primary cancers in testicular cancer patients by histological type
    C Dong
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    Eur J Cancer 37:1878-85. 2001
    ..Our data support the contention that genetic predisposition is one of the major contributors to familial and multiple testicular cancers...
  45. pmc Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor
    Susan N Chi
    Dana Farber Cancer Institute, Children s Hospital Boston, Boston, MA, USA
    J Clin Oncol 27:385-9. 2009
    ..Based on a previous pilot series, a prospective multi-institutional trial was conducted for patients with newly diagnosed CNS ATRT...
  46. ncbi Pluripotency of spermatogonial stem cells from adult mouse testis
    Kaomei Guan
    Department of Cardiology and Pneumology, Heart Center, Georg August University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Nature 440:1199-203. 2006
    ..Furthermore, these cells may provide new opportunities to study genetic diseases in various cell lineages...
  47. ncbi Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal
    Andrea Necchi
    Department of Medicine, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 107:1088-94. 2011
    ..To investigate the optimal management and prognostic factors of patients with malignant transformation (MT) in germ-cell tumour (GCT) by re-evaluating Institutional series...
  48. pmc Standardization of the teratoma assay for analysis of pluripotency of human ES cells and biosafety of their differentiated progeny
    Michal Gropp
    The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 7:e45532. 2012
    b>Teratoma tumor formation is an essential criterion in determining the pluripotency of human pluripotent stem cells. However, currently there is no consistent protocol for assessment of teratoma forming ability...
  49. pmc A scalable approach to prevent teratoma formation of human embryonic stem cells
    Zhili Rong
    Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093 0322, USA
    J Biol Chem 287:32338-45. 2012
    ..through homologous recombination, we developed a safe and highly scalable approach to efficiently eliminate the teratoma risk associated with hESCs without apparent negative impact on their differentiated cell types...
  50. pmc CA19-9 elevation in ovarian mature cystic teratoma: discrimination from ovarian cancer - CA19-9 level in teratoma
    Hye Yon Cho
    Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Hwasung, Gyeonggido, Korea
    Med Sci Monit 19:230-5. 2013
    We aimed to identify clinical characteristics of ovarian mature cystic teratoma (MCT) in association with CA19-9 elevation, and to determine if CA19-9 is a useful marker in discrimination of MCT from ovarian cancer (OC).
  51. ncbi Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line
    J Zhou
    W Alton Jones Cell Science Center, Inc, Lake Placid, New York 12946
    J Biol Chem 268:10863-9. 1993
    PC cell line is a highly tumorigenic insulin-independent variant from the teratoma-derived adipogenic cell line 1246. Culture medium of PC cells contains a growth promoting activity for 3T3 cells and producer cells...
  52. pmc MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation
    Xi Wang
    W M Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Res 72:2867-78. 2012
    ..In vitro predifferentiation of ESCs can help prevent the risk of teratoma formation, yet proliferating neural progenitors can generate tumors, especially in the presence of ..
  53. ncbi Anaesthesia for a patient with paraneoplastic limbic encephalitis with ovarian teratoma: relationship to anti-N-methyl-D-aspartate receptor antibodies
    H Kawano
    Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan
    Anaesthesia 66:515-8. 2011
    Paraneoplastic limbic encephalitis associated with ovarian teratoma has recently been related to the development of antibodies to specific heteromers of the N-methyl-d-aspartate receptor and exhibits various manifestations including ..
  54. pmc Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation
    Nao Suzuki
    Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Mol Ther 21:1424-31. 2013
    ..we demonstrate a unique in vivo differentiation system yielding engraftable HSCs from mouse and human iPSCs in teratoma-bearing animals in combination with a maneuver to facilitate hematopoiesis...
  55. ncbi Adenocarcinoma arising from mature cystic teratoma of the ovary
    Miki Kushima
    Division of Hospital Pathology, Showa University Hospital, Tokyo, Japan
    Pathol Int 54:139-43. 2004
    An extremely rare adenocarcinoma arising from a mature cystic teratoma is reported. A 58-year-old woman underwent bilateral salpingo-oophorectomy because of a tumor in each ovary. The right ovarian tumor (solid, 9.6 x 9.6 x 6...
  56. ncbi Efficient establishment of human embryonic stem cell lines and long-term maintenance with stable karyotype by enzymatic bulk passage
    Hirofumi Suemori
    Laboratory of Embryonic Stem Cell Research, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 345:926-32. 2006
    ..These results provide valuable information that will assist in achieving the goal of the large-scale hES cell culture required for the application of hES cells to disease therapy...
  57. ncbi Metachronous mature teratoma in the corpus callosum occurring 12 years after a pineal germinoma
    Yuuta Kamoshima
    Department of Neurosurgery, Hokkaido University Hospital, Sapporo, Japan
    J Neurosurg 109:126-9. 2008
    ..The histological diagnosis was mature teratoma. The second tumor was considered as a metachronous mature teratoma rather than a recurrence of the original ..
  58. ncbi Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation
    Kaoru Abiko
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Surg Pathol 34:1842-8. 2010
    Immature teratoma of the ovary is an uncommon tumor comprising 1% of ovarian malignancies. The amount of immature neuroepithelium in the teratoma is an important prognostic factor...
  59. ncbi Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology
    Yuh Lih Chang
    Institute of Pharmacology, Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Cell Transplant 21:313-32. 2012
    ..However, teratoma formation is a major concern for transplantation-based therapies...
  60. ncbi Spectrum of intrapartum management strategies for giant fetal cervical teratoma
    Shinjiro Hirose
    Department of Surgery, University of California, San Francisco, California 94143 0570, USA
    J Pediatr Surg 38:446-50; discussion 446-50. 2003
    The management of the fetus with a large neck mass that obstructs the airway remains a clinical challenge. The authors review their experience with giant fetal cervical teratoma and discuss options for management.
  61. ncbi Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data
    Andreas Hackethal
    Department of Obstetrics and Gynecology, Justus Liebig University of Giessen, Giessen, Germany
    Lancet Oncol 9:1173-80. 2008
    ..64 suitable studies provided information on 277 patients. Squamous-cell carcinoma in mature cystic teratoma was mainly found in women aged more than 50 years, with high concentrations of squamous-cell-carcinoma antigen ..
  62. ncbi Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy
    Tal Finkelstein-Shechter
    Bone Marrow Transplant Program, Hospital for Sick Children, Toronto, Canada
    J Pediatr Hematol Oncol 32:e182-6. 2010
    ..To retrospectively review an institutional experience in managing atypical teratoid/rhabdoid tumors (AT/RT) of the Central Nervous System with high-dose chemotherapy in infants and children less than 4 years old...
  63. pmc Mitotic arrest in teratoma susceptible fetal male germ cells
    Patrick S Western
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e20736. 2011
    ..this, there have been few comparative studies aimed at determining the similarities and differences between teratoma susceptible and non-susceptible mouse strains...
  64. ncbi Squamous cell carcinoma arising from primary retroperitoneal mature teratoma
    Leena D Joseph
    Department of Pathology, Sri Ramachandra Medical College and Research Institute DU, Porur, Chennai 600 116, Tamil Nadu, India
    J Assoc Physicians India 55:374-6. 2007
    ..Gross examination showed solid and cystic tumor with sebaceous material admixed with hair. Histopathology showed mature cystic teratoma with a spectrum of well to poorly differentiated squamous cell carcinoma with omental metastasis.
  65. ncbi Primary carcinoid tumor arising in a retroperitoneal mature teratoma in an adult
    Toshinari Yamasaki
    Department of Urology, Himeji National Hospital, 68 Honmachi, Himeji, Hyogo 670 8520, Japan
    Int J Urol 11:912-5. 2004
    An extremely rare case of a primary carcinoid tumor arising in a mature retroperitoneal teratoma is reported. A 53-year-old woman was admitted for further examination of an incidental retroperitoneal mass with calcification...
  66. ncbi Teratomas of the neck and mediastinum in children
    Francesca Martino
    Department of Pediatric Surgery, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Pediatr Surg Int 22:627-34. 2006
    ..During this period we treated 66 children with teratoma of which 11 (6 male and 5 female) had cervicomediastinal locations...
  67. pmc Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation
    Feng Cao
    Cardiology Department of Xijing Hospital, Xi an, China
    Cancer Res 69:2709-13. 2009
    b>Teratoma formation can be a serious drawback after the therapeutic transplantation of human embryonic stem (hES) cells...
  68. ncbi Bevacizumab in a growing teratoma syndrome. Case report
    M Mego
    Ann Oncol 18:962-3. 2007
  69. ncbi Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma
    Yuichi Terado
    Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan
    Pathol Int 60:701-5. 2010
    We report a case of small intestinal type adenocarcinoma arising in retroperitoneal mature cystic teratoma in a young male...
  70. ncbi Papillary renal cell-like carcinoma in a retroperitoneal teratoma
    Zlatko Marusic
    Department of Pathology, Sestre Milosrdnice University Hospital, Zagreb, Croatia
    Pathol Int 60:581-5. 2010
    ..The patient was a 36-year-old man with a synchronous mediastinal teratoma. The somatic type malignancy in the retroperitoneal tumor was composed of papillary structures covered by ..
  71. ncbi Tumourigenesis in the infarcted rat heart is eliminated through differentiation and enrichment of the transplanted embryonic stem cells
    Qiuxia Lin
    Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, 27 Taiping Road, Beijing, People s Republic of China
    Eur J Heart Fail 12:1179-85. 2010
    ..This study aims to evaluate the influence of differentiation and enrichment of transplanted ESCs on tumourigenesis in infarcted rat hearts...
  72. ncbi Direct reprogramming of fibroblasts into epiblast stem cells
    Dong Wook Han
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Munster, Germany
    Nat Cell Biol 13:66-71. 2011
    ..from epiblast tissue of post-implantation embryos are pluripotent and can give rise to all three germ layers in teratoma assays...
  73. ncbi Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models
    Martin G Pomper
    Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Res 19:370-9. 2009
    ..We observed teratoma formation from both types of gene-modified cells as well as wild-type hESCs 2-4 months after inoculation...
  74. pmc Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis
    M Seki
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 79:324-6. 2008
    ..Early removal of an ovarian teratoma followed by plasma exchange and corticosteroids resulted in a prompt neurological response and eventual full ..
  75. pmc Distinct differentiation characteristics of individual human embryonic stem cell lines
    Milla Mikkola
    Program of Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Helsinki, Finland
    BMC Dev Biol 6:40. 2006
    ..Here, we describe the derivation of five hESC lines (called FES 21, 22, 29, 30 and 61) from frozen-thawed human embryos and compare their individual differentiation characteristic...
  76. ncbi Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space
    Stefan Arnhold
    Department of Anatomy I, University of Cologne, Cologne, Joseph Stelzmann Strasse 9, 50931 Koln, Germany
    Invest Ophthalmol Vis Sci 45:4251-5. 2004
    ..To determine whether transplantation of embryonic stem (ES) cells into the subretinal space of rhodopsin-knockout mice has a tumorigenic effect...
  77. pmc Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules
    Ralf Dressel
    Department of Cellular and Molecular Immunology, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Biol Direct 4:31. 2009
    ....
  78. ncbi Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome
    Gerasimos Tzortzatos
    Department of Obstetrics and Gynecology, Karolinska University Hospital Karolinska Institute, Stockholm, Sweden
    Fertil Steril 91:936.e1-3. 2009
    To report a case of successful IVF-pregnancy after treatment for ovarian growing teratoma syndrome.
  79. ncbi Expression of a specific mouse germ cell nuclear antigen (GCNA1) by early embryonic testicular teratoma cells in 129/Sv-Sl/+ mice
    D Wang
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, 66160 7400, USA
    Cancer Lett 100:31-6. 1996
    ..5 days post coitum (dpc) embryonic testes. These pluripotent teratoma stem cells are capable of differentiating into many kinds of tissues in adult mice...
  80. ncbi Prognosis and treatment of squamous cell carcinoma from a mature cystic teratoma of the ovary
    Ruey Jien Chen
    Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 107:857-68. 2008
    Squamous cell carcinoma (SCC) arising from a mature cystic teratoma of the ovary is rare and only reported sporadically. Clinical information on the disease is limited...
  81. doi Testicular teratoma and anti-N-methyl-D-aspartate receptor-associated encephalitis
    A Eker
    J Neurol Neurosurg Psychiatry 79:1082-3. 2008
  82. ncbi Dermoid cyst (mature cystic teratoma) of the cecum. Histologic and cytologic features with review of the literature
    Maurice Joseph Schuetz
    Department of Pathology, Ball Memorial Hospital, Muncie, IN 47303, USA
    Arch Pathol Lab Med 126:97-9. 2002
    ..to describe fine-needle aspiration cytologic findings in addition to histologic features of a mature cystic teratoma involving the gastrointestinal tract...
  83. ncbi hCG-secreting pineal teratoma causing precocious puberty: report of two patients and review of the literature
    Katia Nogueira
    Department of Endocrinology, Hospital Brigadeiro, Sao Paulo SP, Brazil
    J Pediatr Endocrinol Metab 15:1195-201. 2002
    Two boys are described with precocious puberty (PP) due to pineal immature teratoma associated with choriocarcinoma. Patient 1 was a 7 year-old boy with a 2-year history of PP. He had elevated CSF and plasma beta-hCG levels...
  84. ncbi Chemotherapy for teratoma with malignant transformation
    Alessia C Donadio
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 21:4285-91. 2003
    b>Teratoma with malignant transformation (MT) is a well-described entity that refers to the MT of a somatic teratomatous component in a germ cell tumor (GCT) to a histology that is identical to a somatic malignancy (eg, rhabdomyosarcoma [..
  85. ncbi mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation
    J M Hebert
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 112:407-15. 1991
    ....
  86. ncbi The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells
    Barak Blum
    Stem Cell Unit, Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel
    Nat Biotechnol 27:281-7. 2009
    ..We suggest that continued expression of survivin upon differentiation in vivo may contribute to teratoma formation by hES cells.
  87. ncbi A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice
    T Noguchi
    J Natl Cancer Inst 75:385-92. 1985
    ..The germ cell deficiency resulted from the homozygous state of a recessive mutant gene designated "teratoma (ter)...
  88. pmc Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 118:737-43. 2009
    ....
  89. ncbi mAb 84, a cytotoxic antibody that kills undifferentiated human embryonic stem cells via oncosis
    Heng Liang Tan
    Bioprocessing Technology Institute, Singapore
    Stem Cells 27:1792-801. 2009
    ..The perturbation of these actin-associated proteins consequently permits the aggregation of PODXL, thus leading to the formation of pores. To our knowledge, this is the first report of oncotic cell death with hESCs as a model...
  90. ncbi Variation in the safety of induced pluripotent stem cell lines
    Kyoko Miura
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Nat Biotechnol 27:743-5. 2009
    We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways...
  91. ncbi Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
    M Amit
    Department of Obstetrics and Gynecology, Technion, Haifa, 31096, Israel
    Dev Biol 227:271-8. 2000
    ..The remarkable developmental potential, proliferative capacity, and karyotypic stability of human ES cells distinguish them from adult cells...
  92. ncbi The tumorigenicity of diploid and aneuploid human pluripotent stem cells
    Barak Blum
    Stem Cell Unit, Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Cell Cycle 8:3822-30. 2009
    ..We also discuss the differences in the tumorigenicity between mouse embryonic stem cells (MESCs) and HESCs, and suggest methodologies that may help to identify cellular markers for culture adapted HESCs...
  93. ncbi Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor
    Mary Ann Zimmerman
    Department of Pediatric Oncology, Pediatric Neuro Oncology, Dana Farber Cancer Institute, Rm SW331, 44 Binny Street, Boston, MA 02115, USA
    J Neurooncol 72:77-84. 2005
    ..More importantly, we report on the first two survivors after relapse with multi-agent intravenous and intrathecal chemotherapy treated with this modified regimen...
  94. ncbi The growing teratoma syndrome
    Katherine Nimkin
    Department of Radiology, The Floating Hospital for Children, Boston, MA, USA
    Pediatr Radiol 34:259-62. 2004
    Growing teratoma syndrome is defined as enlarging masses of mature teratoma following chemotherapy for malignant nonseminomatous germ-cell tumors. Typically, there is associated normalization of initially elevated serum tumor markers...
  95. ncbi Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium
    Rutger Jan Swijnenburg
    Department of Surgery, Leiden University School of Medicine, The Netherlands
    Circulation 112:I166-72. 2005
    ..We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection...
  96. pmc A patient with encephalitis associated with NMDA receptor antibodies
    Lauren H Sansing
    Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Nat Clin Pract Neurol 3:291-6. 2007
    ..There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm...
  97. pmc Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02178, USA
    J Neurochem 97:1467-80. 2006
    ..this potential therapy is the elimination of undifferentiated cells that, even in low numbers, could result in teratoma formation in the host brain...
  98. ncbi Growing teratoma syndrome vs chemotherapeutic retroconversion: case report and review of the literature
    H Amsalem
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem 91240, Israel
    Gynecol Oncol 92:357-60. 2004
    Immature ovarian teratoma is the third most common germ cell tumor (GCT) following dysgerminoma and endodermal sinus tumor...
  99. ncbi Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures
    Charli Kruse
    Fraunhofer lnstitute of Biomedical Engineering, Group of Cell Differentiation and Cell Technology at the University of Lübeck, MFC Innovationscampus 1, Maria Goeppert Strasse 1, D 23538 Lubeck, Germany
    Ann Anat 188:503-17. 2006
    ..differentiation into various cell lineages; (iv) the cells have the propensity to form three-dimensional, teratoma-like structures in vitro, which contain cells of different lineages; and (v) external stimuli can activate the ..
  100. ncbi Adenocarcinomas arising from primary retroperitoneal teratoma in an adult female patient
    Pei Yi Chu
    Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Urol 13:1352-4. 2006
    Presented herein is a case of primary retroperitoneal teratoma with adenocarcinomatous transformation predominantly composed of signet ring cell carcinoma and intestinal-type adenocarcinoma in a 36-year-old woman...
  101. pmc Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    Paul S Knoepfler
    Department of Cell Biology and Human Anatomy and Stem Cell Program, University of California Davis School of Medicine, Sacramento, CA, USA
    Stem Cells 27:1050-6. 2009
    ..hESC) shared not only pluripotency with their EC cousins, but also robust tumorigenicity as each readily form teratoma. Surprisingly, decades after the discovery of mESC, the question of what drives ESC to form tumors remains ..

Research Grants62

  1. Studying a Human Stem Cell Disease Using iPS Technology
    Steven E Artandi; Fiscal Year: 2010
    ..studies in DC iPS cells and (3) Analysis of differentiation of DC iPS cells through embryoid body formation, teratoma development and directed differentiation to hematopoietic stem cells (HSCs)...
  2. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ..In about 60% of these patients, the trigger of the immune response was an ovarian teratoma that contained ectopic nervous tissue expressing NMDAR...
  3. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2012
    ..of undifferentiated tumor- initiating cells after administration of ganciclovir will be assessed in vitro and in teratoma formation assays...
  4. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ..In about 60% of patients, the immune trigger was an ovarian teratoma with ectopic nervous tissue and expressed NMDAR...
  5. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2013
    ..of undifferentiated tumor- initiating cells after administration of ganciclovir will be assessed in vitro and in teratoma formation assays...
  6. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..cells (iPS) are versatile sources of stem cells with multiple differentiation potential, however concerns such as teratoma formation and immunogenic rejection remain as obstacles...
  7. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Lines that grow vigorously and demonstrate full in vitro and in vivo (teratoma) criteria for pluripotency will then be tested for their ability to participate in chimera production...
  8. iPS-derived hepatocytes as a model of familial hypercholesterolemia
    Max A Cayo; Fiscal Year: 2013
    ..iPSC by immunostaining/fluorescence microscopy, flow cytometry, DNA fingerprint STR analysis, karyotyping, and teratoma assay...
  9. Employing Familial AD Induced Pluripotent Stem Cells to Study Neurodegeneration
    Suman Jayadev; Fiscal Year: 2013
    ..created multiple iPSC lines which are being fully characterized molecularly, epigenetically and for capacity for teratoma formation among other crucial iPSC requirements...
  10. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..The strategy involves finding the minimum number of ESCs needed to form a teratoma with the goal of redirecting these ESCs to form only one organ type...
  11. Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1
    Blanche Capel; Fiscal Year: 2013
    ..to identify interacting miRNAs and possible strain differences that may account for the different sensitivity to teratoma formation...
  12. Generation of hESC reporter lines using improved gene targeting technology
    TOBIAS DIETMAR RAABE; Fiscal Year: 2010
    ..and tested for pluripotency by gene expression profiling, DNA methylation profiling, in vitro differentiation and teratoma formation in mice...
  13. Nonhuman primate induced pluripotent stem cells in regenerative medicine
    Peter J Hornsby; Fiscal Year: 2013
    ..of the existence of a differentiation-resistant subpopulation of cells that could represent a risk for teratoma development? We will examine if there is long-term continued proliferation of transplanted cells in the mouse CNS...
  14. Rapid Multiplexed Nanoprobe Assays for Pluripotent Stem Cell Differentiation
    David Larocca; Fiscal Year: 2013
    ..In vivo testing in SCID mice for teratoma formation takes 6-12 weeks and is therefore not practical for initial iPS screening...
  15. Dopaminergic transcription factor delivery to fibroblast derived neurons
    Paul S Fishman; Fiscal Year: 2013
    ..embryonic stem cell (ESC) or an induced pluripotent stem cell (iPSC), cell types with a risk of tumor formation (teratoma) after long term transplantation into the brain...
  16. Genome correction of Myotonic Dystrophy type 1 iPS cells by TALEN technology
    Guangbin Xia; Fiscal Year: 2013
    ..vitro and in vivo pluripotency of genome- corrected DM1 iPS cells by embryoid body-mediated differentiation and teratoma formation...
  17. Elucidating molecular basis of ICF Syndrome with human pluripotent stem cells
    Guoping Fan; Fiscal Year: 2013
    ..expression of pluripotency markers and multi-potentials of cell differentiation through embryoid formation and teratoma formation...
  18. Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs
    Jianqing Fan; Fiscal Year: 2013
    ..to advance both novel statistical methods for genomic research and discoveringcomplex molecular mechanisms on the teratoma initiation and progression after transplantation ofembryonic stem cells (ESCs)...
  19. Derivation of human pluripotent stem cells using small molecules
    Yanhong Shi; Fiscal Year: 2010
    ..leaky expression of transgenes may inhibit iPS cell differentiation, increasing the risk of immature teratoma formation...
  20. Comprehensive in vivo MRI of mouse embryonic stem cell myocardial engraftment
    PHILLIP CHUNG MING YANG; Fiscal Year: 2012
    ..research, further investigation to enhance in vivo cellular and molecular MRI of mESC survival and proliferation (teratoma formation) following transplantation into the myocardium is described...
  21. Development of iPS cells to study craniometaphyseal dysplasia in humans
    ERNST J REICHENBERGER; Fiscal Year: 2010
    ..for normal karyotype, gene expression profile, epigenetic profile and will be tested for pluripotency using teratoma assays...
  22. Reagents for Targeted Ablation of Residual Contaminating Pluripotent Stem Cells
    David Larocca; Fiscal Year: 2013
    ..The ability to the optimal hPS-CTT to remove hPS cells will be tested using an in vivo teratoma assay...
  23. High throughput Electrophysiological Purification Array (HEPA) for cell based the
    John Collins; Fiscal Year: 2013
    ..But establishment of effective separation methods to isolate differentiated cells and exclude cells that lead to teratoma formation is the major challenge in translating advances in stem cell biology into tissue replacement therapies...
  24. CELLULAR ENGINEERING OF HEPATOCYTE CELL LINES
    Ira J Fox; Fiscal Year: 2010
    ..and lineage- specific isolation of mES- and hES- derived hepatocytes will reduce their potential for teratoma development, and thus make them safer for clinical use...
  25. Derivation of Functional Neurons from Human Adult Cells by Nonviral Gene Delivery
    Kam W Leong; Fiscal Year: 2013
    ..neurons, and induced pluripotent stem cell-derived neurons all suffer from concerns of ethical issues and/or teratoma formation...
  26. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2013
    ..are differentially expressed in a unique tumor bank enabling comprehensive analyses of differentiated (mature teratoma) versus undifferentiated (EC) GCTs...
  27. Biological Insights into Dynamics of Stem Cell Differentiation and Misbehavior
    Joseph Wu; Fiscal Year: 2009
    ..However, one of the most devastating risks of using hESCs remains the possibility of cellular misbehavior (i.e., teratoma formation)...
  28. Primordial germ cell differentiation and the initiation of testicular cancer
    Jason D Heaney; Fiscal Year: 2013
    ..A combination of of in vitro and in vivo teratoma formation assays, expression assays, loss-of-function mutations, and pluripotency and tumorigenicity assays will ..
  29. The role of mitochondria in embryonic stem cells.
    Jalees Rehman; Fiscal Year: 2013
    ..how enhancing mitochondrial glucose oxidation affects the therapeutic use of hESC by using in vivo models of teratoma formation and angiogenesis...
  30. Pluripotency of Amniotic Fluid-Derived Stem Cells
    COLIN EDWARD BISHOP; Fiscal Year: 2010
    ..should lead to significant insights into functions essential for pluripotency and also into those associated with teratoma formation...
  31. In Vivo Assessment of Embryonic Stem Cell Teratoma Prevention
    Horst A von Recum; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible...
  32. GENETIC HETEROGENEITY IN HUMAN DISEASE
    Aravinda Chakravarti; Fiscal Year: 1992
    ..We shall extend these methods for multi-point mapping and to analyze teratoma/trisomy data for constructing centromere-based gene maps...
  33. DIFFERENTIATION AND STROMA-INDUCTION IN NEURAL TUMORS
    LUCIEN RUBINSTEIN; Fiscal Year: 1980
    ..glial rat tumor cell line (C-6); and the neuroepithelial component of a transplantable mouse testicular teratoma (OTT-6050) maintained in syngeneic animal in ascitic and in solid forms. Two main approaches are used: 1...
  34. TAXOL PRODUCTION VIA IN VITRO CULTURE TECHNIQUE
    CHING YEH HU; Fiscal Year: 1992
    ..nodule cultures," (2) genetically stable fast-grown "hairy roots," and/or (3) genetically stable, fast-grown "teratoma." After nodule culture, hairy root and/or teratoma tissues established, their taxol production capacity will be ..
  35. GENETICS AND BIOLOGY OF HUMAN OVARIAN TERATOMAS
    Urvashi Surti; Fiscal Year: 1992
    ..ovarian teratomas and corresponding normal ovarian tissue, to determine the mechanism of origin of each ovarian teratoma and to estimate the relative frequency of each mechanism...
  36. Cell therapy of diabetes using broad spectrum multipotent stem cells
    Shay Soker; Fiscal Year: 2007
    ..Amniotic fluid-derived stem (AFS) cells can be expanded extensively in culture, do not form teratoma tumors, and have the capacity to yield a variety of specialized cell types...
  37. GENETIC STUDIES OF LINKAGE AND RECOMBINATION
    Aravinda Chakravarti; Fiscal Year: 1991
    ..We plan to extend these methods for multi-point mapping and to analyze teratoma/trisomy data for constructing multi-point gene maps...
  38. ORIGIN OF TRANSGENE-RELATED OVARIAN TERATOCARCINOMAS
    J Chaillet; Fiscal Year: 2000
    ..A teratocarcinoma is a malignant form of teratoma that contains undifferentiated EC cells in addition to differentiated derivatives...
  39. CASE CONTROL STUDY OF BENIGN OVARIAN NEOPLASMS
    Carolyn Westhoff; Fiscal Year: 1993
    ..We expect to complete in-person interviews with about 1000 cases, including at least 330 women who has a mature teratoma, 190 women who had an endometrioma, and 460 women who had one of the following benign epithelial tumors: ..
  40. Translational research and education in cell therapies for vascular regeneration
    John Cooke; Fiscal Year: 2009
    ..imaging to assess cell incorporation and survival (as well as to detect complications, such as muscle necrosis or teratoma)...
  41. CELLULAR MECHANISMS OF OVARIAN TERATOCARCINOGENESIS
    John Eppig; Fiscal Year: 2002
    ..Moreover, since clinical therapies targeting oocyte meiosis for fertility control might increase the risk of teratoma development, it is critical to devise strategies to understand what these risks are and how they might be avoided...
  42. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 2000
    ..GCTs also display somatic differentiation (teratoma, usually histologically benign)...
  43. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
    ..embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic lineages, ectoderm, mesoderm, and ..
  44. DIFFERENTIATION AND STROMA-INDUCTION IN NEURAL TUMORS
    Robert Carey; Fiscal Year: 1990
    ..The neuroepithelial component of a transplantable mouse testicular teratoma (OTT-6050) and of its enriched fractions obtained by dissociation and centrifugal elutriation, an experimental ..
  45. CELL CULTURE FACTORS & THEIR RELATION TO CANCER BIOLOGY
    WALLACE MC KEEHAN; Fiscal Year: 1992
    ..alterations in growth factor regulation that is associated with tumorigenicity will be explored in variants of teratoma cells...
  46. CROWN GALL TUMOR DISEASE: SUPPRESSION AND RECOVERY
    Robert Turgeon; Fiscal Year: 1980
    Our laboratory is currently studying growth control in the crown gall teratoma of plants. These tumors will, under appropriate conditions, produce well-formed shoots composed of tumor cells...
  47. Characterizing marrow derived cells for neural therapy
    KENDRICK BOARDMAN; Fiscal Year: 2005
    ..from embryonic stem cells and NSCs directly isolated from brains are fraught with a number of technical (tumor-/teratoma- genesis, uncontrolled multipotency, sourcing, require immune suppression) and ethical hurdles which have ..
  48. CELLULAR ONCOGENES IN GERM CELL TUMORS
    George Mutter; Fiscal Year: 1993
    ..system to directly study gene expression from the time of neoplastic transformation through proliferation into a teratoma. Using probes for genes regulated during normal gametogenesis and embryogenesis, including c-oncs, ..
  49. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  50. Mechanisms of Scar-Free Healing in the Fetal Artery
    DARRELL CASS; Fiscal Year: 2008
    ..His long term objective is to apply this knowledge clinically in both children and adults to limit vascular inflammation, neointimal hyperplasia and scarring. [unreadable] [unreadable] [unreadable]..
  51. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  52. Mechanisms of Neurodegeneration
    Roger J Davis; Fiscal Year: 2010
    ..The Specific Aims of this proposal are to examine: 1. The physiological role of JNK in neurons. 2. The mechanism of JNK-induced neurodegeneration. ..
  53. Consequences and Course of Uterine Fibroids in Pregnancy
    Katherine Hartmann; Fiscal Year: 2008
    ..By prospectively investigating fibroid characteristics and risk, this research has potential to inform care for many women with fibroids who are pregnant or planning pregnancy. ..
  54. MOLECULAR CLONING OF THE FRAGILE X SITE
    Stephen T Warren; Fiscal Year: 2011
    ..Deep fundamental knowledge of a disease is the best course toward eventual therapeutics. ..
  55. Epigenetic Marks as Peripheral Biomarkers of Autism
    Stephen T Warren; Fiscal Year: 2010
    ..These data not only could provide new insight into the causes of autism but could also result in a screening test for autism. ) ..
  56. SIGNAL TRANSDUCTION BY THE EGF RECEPTOR
    Roger Davis; Fiscal Year: 2001
    ..In the second aim, the investigator will attempt to identify target molecules that interact with ZPR1. In the third specific aim, the investigator will determine ZPR1 function using genetic analysis in yeast. ..
  57. Imaging Serotonergic Transmission in HIV Depression
    Martin Pomper; Fiscal Year: 2006
    ..abstract_text> ..
  58. A PROGRAM OF INVESTIGATION INTO FRAGILE X SYNDROME
    Stephen Warren; Fiscal Year: 2005
    ..abstract_text> ..
  59. Cardioprotective Repair through Cardiopoiesis
    Andre Terzic; Fiscal Year: 2010
    ..abstract_text> ..
  60. OCULAR MELANOMA
    David Wilson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..