neuroendocrine carcinoma

Summary

Summary: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. ncbi Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features
    Pavel Dundr
    Department of Pathology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Pathol Res Pract 199:559-63. 2003
  2. ncbi Neuroendocrine carcinomas (carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma): current concepts
    Cesar A Moran
    Department of Pathology, University of Texas M D Anderson Cancer Center, Unit 85, 1515 Holcombe, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 21:395-407; vii. 2007
  3. ncbi Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma
    Bing Wei
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, China
    Cancer 116:4463-73. 2010
  4. ncbi Neuroendocrine differentiation and prognosis in breast adenocarcinoma
    A Miremadi
    Department of Histopathology, Nottingham City Hospital, Nottingham, UK
    Histopathology 40:215-22. 2002
  5. ncbi Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature
    Nitin Agarwal
    Department of Surgery, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi, India
    JOP 10:55-8. 2009
  6. ncbi DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung
    T Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 29:4671-81. 2010
  7. ncbi Primary small-cell neuroendocrine carcinoma of the breast: report of a case
    Satoki Kinoshita
    Department of Breast and Endocrine Surgery, Jikei University Kashiwa Hospital, 163 1 Kashiwashita, Kashiwa, Chiba, 277 8567, Japan
    Surg Today 38:734-8. 2008
  8. ncbi Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer
    Andrew J Evans
    Department of Pathology and Laboratory Medicine, University Health Network, Mt Sinai Hospital, Toronto, Ontario, Canada
    Am J Surg Pathol 30:684-93. 2006
  9. ncbi Phase II trial of paclitaxel, carboplatin, and etoposide in advanced poorly differentiated neuroendocrine carcinoma: a Minnie Pearl Cancer Research Network Study
    John D Hainsworth
    Sarah Cannon Research Institute, Nashville, TN 37203, USA
    J Clin Oncol 24:3548-54. 2006
  10. ncbi Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity
    Akira Iyoda
    Department of Thoracic Surgery, Chiba, Japan
    Ann Thorac Surg 77:1891-5; discussion 1895. 2004

Research Grants

Detail Information

Publications276 found, 100 shown here

  1. ncbi Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features
    Pavel Dundr
    Department of Pathology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Pathol Res Pract 199:559-63. 2003
    ..undifferentiated carcinoma, giant cell carcinoma, lymphoepithelioma-like carcinoma (LELC), and large cell neuroendocrine carcinoma (LCNEC)...
  2. ncbi Neuroendocrine carcinomas (carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma): current concepts
    Cesar A Moran
    Department of Pathology, University of Texas M D Anderson Cancer Center, Unit 85, 1515 Holcombe, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 21:395-407; vii. 2007
    ..Close clinical correlation and appropriate treatment are important to improve the survival rate in this group of patients...
  3. ncbi Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma
    Bing Wei
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, China
    Cancer 116:4463-73. 2010
    b>Neuroendocrine carcinoma (NEC) of the breast, a pathologic entity newly defined in the 2003 World Health Organization classification of tumors, is a rare type of tumor that is not well recognized or studied...
  4. ncbi Neuroendocrine differentiation and prognosis in breast adenocarcinoma
    A Miremadi
    Department of Histopathology, Nottingham City Hospital, Nottingham, UK
    Histopathology 40:215-22. 2002
    ..To date there are few detailed studies examining its relevance in breast carcinoma. In this study we evaluate the frequency and prognostic importance of neuroendocrine differentiation in breast adenocarcinoma...
  5. ncbi Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature
    Nitin Agarwal
    Department of Surgery, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi, India
    JOP 10:55-8. 2009
    ..The management of these tumors poses a challenge due to their rarity and uncertain malignant potential. We report a case of diffuse serous cystadenoma associated with neuroendocrine carcinoma in a 35-year-old woman.
  6. ncbi DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung
    T Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 29:4671-81. 2010
    ..carcinoma show similar histological features and clinical behaviors, and can be classified as high-grade neuroendocrine carcinoma (HGNEC) of the lung...
  7. ncbi Primary small-cell neuroendocrine carcinoma of the breast: report of a case
    Satoki Kinoshita
    Department of Breast and Endocrine Surgery, Jikei University Kashiwa Hospital, 163 1 Kashiwashita, Kashiwa, Chiba, 277 8567, Japan
    Surg Today 38:734-8. 2008
    Primary small-cell neuroendocrine carcinoma of the breast is a rare and aggressive neoplasm without an established treatment protocol because so few cases have been described...
  8. ncbi Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer
    Andrew J Evans
    Department of Pathology and Laboratory Medicine, University Health Network, Mt Sinai Hospital, Toronto, Ontario, Canada
    Am J Surg Pathol 30:684-93. 2006
    ..LCNEC of prostate is a distinct clinicopathologic entity that typically manifests after long-term hormonal therapy for prostatic adenocarcinoma and likely arises through clonal progression under the selection pressure of therapy...
  9. ncbi Phase II trial of paclitaxel, carboplatin, and etoposide in advanced poorly differentiated neuroendocrine carcinoma: a Minnie Pearl Cancer Research Network Study
    John D Hainsworth
    Sarah Cannon Research Institute, Nashville, TN 37203, USA
    J Clin Oncol 24:3548-54. 2006
    ..To evaluate the efficacy of chemotherapy with paclitaxel, carboplatin, and etoposide in advanced adult poorly differentiated neuroendocrine carcinomas...
  10. ncbi Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity
    Akira Iyoda
    Department of Thoracic Surgery, Chiba, Japan
    Ann Thorac Surg 77:1891-5; discussion 1895. 2004
    In 1999, the World Health Organization classified large cell neuroendocrine carcinoma as a variant of large cell carcinoma and this has been categorized as lying between atypical carcinoid and small cell lung carcinoma in terms of ..
  11. ncbi High-grade neuroendocrine carcinoma arising in a gastric duplication cyst: a case report with literature review
    Garnet Horne
    Departments of Pathology and Laboratory Medicine, University of Calgary, and Calgary Laboratory Services, Calgary, Alberta, Canada
    Int J Surg Pathol 15:187-91. 2007
    ..Herein, the authors report the first case of a high-grade neuroendocrine carcinoma arising in a gastric duplication cyst in a 40-year-old Asian male...
  12. ncbi Neuroendocrine differentiated carcinomas of the breast: a distinct entity
    Osman Zekioglu
    Ege University School of Medicine Pathology Department, Bornova, Izmir 35100, Turkey
    Breast 12:251-7. 2003
    Some primary carcinomas of the breast have been classified as neuroendocrine. In this paper we report on 12 cases of neuroendocrine carcinoma of the breast displaying common and uncommon histological features.
  13. ncbi Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA, USA
    Gynecol Oncol 93:27-33. 2004
    ..To analyze the sites of relapse and overall survival in women with neuroendocrine marker-positive small cell carcinoma of the cervix...
  14. ncbi A case of solid neuroendocrine carcinoma of the breast in a 40-year-old woman
    Yasuhisa Fujimoto
    Second Department of Surgery, Hyogo College of Medicine, Japan
    Breast Cancer 14:250-3. 2007
    We report a case of neuroendocrine carcinoma in a 40-year-old woman who presented with two lumps in her left breast...
  15. ncbi Synchronous metastases to the liver and pancreas from a primary neuroendocrine carcinoma of the breast diagnosed by fine-needle aspiration
    Maria McIntire
    Department of Pathology, Rush University Medical Center, Chicago, Illinois 60618, USA
    Diagn Cytopathol 36:54-7. 2008
    Extrapulmonary neuroendocrine carcinoma is uncommon. Cases of primary neuroendocrine carcinoma of the breast have been reported, though rare...
  16. ncbi Large cell neuroendocrine carcinoma of the ampulla of vater
    Alberto Cavazza
    Department of Pathology, S Maria Nuova Hospital, Reggio Emilia, Italy
    Arch Pathol Lab Med 127:221-3. 2003
    We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery...
  17. ncbi Prostatic metastasis of large cell neuroendocrine carcinoma of the lung
    Jeong Hwan Yoo
    Department of Internal Medicine, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Seongnam City, Kyeonggi do 463 712, Korea
    Respirology 14:772-5. 2009
    Large cell neuroendocrine carcinoma (LCNEC) of the lung is a rare and aggressive tumour with a poor prognosis. Lung cancer metastases to the prostate are also uncommon, and are usually found incidentally during autopsy...
  18. ncbi Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications
    Kung Liahng Wang
    Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taiwan, ROC
    J Chemother 18:209-16. 2006
    ..There are two cases of atypical carcinoid tumor (ACT), four cases of large-cell neuroendocrine carcinoma (LCNEC), and 25 cases of small-cell neuroendocrine carcinoma (SCNEC)...
  19. ncbi Neuroendocrine carcinoma of unknown primary site
    David R Spigel
    Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, TN, USA
    Semin Oncol 36:52-9. 2009
    ..Tumor grade/differentiation currently is an important determinant of the management of these patients, and therapy in the future will be based on a more precise knowledge of the unique biology of these tumors...
  20. pmc Ectopic Cushing' syndrome caused by a neuroendocrine carcinoma of the mesentery
    Mathias Fasshauer
    Division of Endocrinology and Nephrology, University of Leipzig, Philipp Rosenthalstr 27, 04103 Leipzig, Germany
    BMC Cancer 6:108. 2006
    ..Here, we report the first case of Cushing' syndrome caused by an ectopic ACTH-secreting neuroendocrine carcinoma of the mesentery...
  21. ncbi Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colon
    Tomoya Kato
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 55:524-9. 2005
    Herein is presented a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma of the colon, in which the tumor was clinically at stage IV and located in the ascending colon...
  22. ncbi Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses
    E Babin
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital, CHU Caen, Caen, France
    J Laryngol Otol 120:289-97. 2006
    Small cell neuroendocrine carcinoma (SNEC) of the sinonasal tract is a rare disease.
  23. ncbi Primary large cell neuroendocrine carcinoma of the urinary bladder
    Andrew J Evans
    Department of Pathology, University Health Network, University of Toronto, Ontario, Canada
    Arch Pathol Lab Med 126:1229-32. 2002
    ..We report a case of primary large cell neuroendocrine carcinoma of the bladder, with an admixed minor element of adenocarcinoma, in an 82-year-old man...
  24. ncbi Primary, pure, large-cell neuroendocrine carcinoma of the urinary bladder
    S Hailemariam
    University of Zurich, Switzerland
    Mod Pathol 11:1016-20. 1998
    ..is the first case in the English-language literature of a primary, pure, undifferentiated large-cell neuroendocrine carcinoma of the urinary bladder...
  25. ncbi Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer
    Richard J Battafarano
    Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 130:166-72. 2005
    ..The objective of this study was to report the outcome of surgical resection in patients with large cell neuroendocrine carcinomas...
  26. ncbi Primary large cell neuroendocrine carcinoma of the urinary bladder
    Shusuke Akamatsu
    Department of Urology, Nishi Kobe Medical Center, Kobe, Hyogo, Japan
    Int J Urol 15:1080-3. 2008
    Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is rare. It is a type of neuroendocrine carcinoma morphologically distinct from small cell carcinoma. We report here a case of primary LCNEC of the urinary bladder...
  27. ncbi Primary large cell neuroendocrine carcinoma of the urinary bladder
    Kyung Hwa Lee
    Department of Pathology, Chonnam National University Medical School, Gwangju, Korea
    Pathol Int 56:688-93. 2006
    ..In spite of three cycles of chemotherapy, the patient developed multiple metastases in the lung and liver 10 months postoperatively. LCNEC of the urinary bladder are uncommon entities, which have a possible fatal outcome...
  28. ncbi High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases
    Hind Nassar
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:588-94. 2005
    We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and ..
  29. ncbi Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma
    Yoo Duk Choi
    Department of Pathology, Chonnam National University Medical School, 5 Hak dong, Dong Gu, Gwangju, 501 749, Republic of Korea
    Gynecol Oncol 104:747-52. 2007
    b>Neuroendocrine carcinoma of the non-small cell type of the ovary is a rare aggressive tumor, interestingly associated with either a surface epithelial tumor or teratoma.
  30. ncbi Large cell neuroendocrine carcinoma of the parotid gland: case report and literature review
    Pablo Casas
    Service of Otorhinolaryngology, La Paz University Hospital, P o de la Castellana 261, 28046 Madrid, Spain
    Auris Nasus Larynx 32:89-93. 2005
    ..Only four cases of large cell neuroendocrine carcinoma (LCNEC) of the salivary gland have been communicated. All of them have involved the parotid gland...
  31. ncbi Immunohistochemical differential diagnosis between large cell neuroendocrine carcinoma and small cell carcinoma by tissue microarray analysis with a large antibody panel
    Jun ichi Nitadori
    Pathology Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa shi, Chiba 277 8577, Japan
    Am J Clin Pathol 125:682-92. 2006
    To elucidate additional phenotypic differences between large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC), we performed tissue microarray (TMA) analysis of surgically resected LCNEC and SCLC specimens...
  32. pmc Small-cell neuroendocrine carcinoma of the prostate: are heterotransplants a better experimental model?
    Lluis A Lopez-Barcons
    Stanley S Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    Asian J Androl 12:308-14. 2010
    Small-cell neuroendocrine carcinoma of the prostate (SCNCP) is an uncommon type of prostate cancer. However, it is of clinical importance because it is one of the most aggressive tumors of the prostate with a very poor prognosis...
  33. ncbi Large-cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighteen cases and the efficacy of adjuvant treatment with octreotide
    Pier Luigi Filosso
    Department of Thoracic Surgery, San Giovanni Battista Hospital, University of Torino, Torino, Italy
    J Thorac Cardiovasc Surg 129:819-24. 2005
    ..This study was undertaken to evaluate the efficacy of a new adjuvant protocol with octreotide, alone or in combination with radiotherapy, in radically resected large cell neuroendocrine carcinomas of the lung...
  34. ncbi Clinical response of large cell neuroendocrine carcinoma of the lung to perioperative adjuvant chemotherapy
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, Nishishinjuku, Shinjuku ku, Japan
    Anticancer Drugs 21:89-93. 2010
    Patients with large cell neuroendocrine carcinoma (LCNEC) of the lung are considered to have poor prognosis. However, the benefit of adjuvant chemotherapy for these patients has not been established...
  35. pmc Small cell neuroendocrine carcinoma of the breast: a report of three cases and review of the literature
    T Adegbola
    Department of Histopathology, University College Hospital, Galway, Republic of Ireland
    J Clin Pathol 58:775-8. 2005
    Small cell neuroendocrine carcinoma of the breast is a rare tumour with less than 30 cases reported in the literature...
  36. ncbi Immunohistochemical characterization of a hepatic neuroendocrine carcinoma in a cat
    Patricia Ferreira-Neves
    Ecole Nationale Veterinaire d Alfort, Unité d Histologie et d Anatomie Pathologique, 7 Avenue du General de Gaulle, 94704 Maisons Alfort cedex, France
    J Vet Diagn Invest 20:110-4. 2008
    ..All these features were consistent with a hepatic neuroendocrine carcinoma and emphasized the importance of using a panel of antibodies to diagnose such rare tumors.
  37. ncbi Hepatobiliary neuroendocrine carcinoma in cats: a clinicopathologic, immunohistochemical, and ultrastructural study of 17 cases
    A K Patnaik
    Department of Veterinary Pathology, The Animal Medical Center, 510 East 62nd Street, New York, NY 10021, USA
    Vet Pathol 42:331-7. 2005
    Hepatobiliary neuroendocrine carcinoma was diagnosed in 17 cats in a period of 10 years. Seven tumors were of intrahepatic origin, one of which was a composite containing components of epithelial and neuroendocrine carcinoma...
  38. ncbi Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis
    K Kusafuka
    Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Sunto gun, Shizuoka 411 8777, Japan
    Int J Oral Maxillofac Surg 38:296-9. 2009
    A case of large cell neuroendocrine carcinoma (LCNEC) of the tongue base is described. It was characterized by solid tumor nests with central necrosis and rosette formation resembling basaloid squamous cell carcinoma...
  39. ncbi Paclitaxel and carboplatin for large cell neuroendocrine carcinoma of the uterine cervix
    Siriwan Tangjitgamol
    Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand
    J Obstet Gynaecol Res 33:218-24. 2007
    The prognosis of large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is generally poor despite multimodality of treatments...
  40. ncbi Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervix
    Hiroshi Kajiwara
    Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Arch Gynecol Obstet 279:521-5. 2009
    ..SSTR2A-positive neuroendocrine tumors may be treatable by SS analogues. Uterine cervical neuroendocrine carcinoma is generally associated with poor prognosis.
  41. ncbi High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes
    Takashi Ibe
    Division of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Surg Oncol 102:11-7. 2010
    ..Thymidylate synthase (TS) expression has been reported in various tumors, including non-small-cell lung carcinoma (NSCLC), but not in high-grade neuroendocrine (HGNE) carcinoma of the lung...
  42. ncbi Synchronous adenocarcinoma of the lung and neuroendocrine carcinoma of the ileum
    Daniel Reim
    Int J Colorectal Dis 23:325-7. 2008
  43. ncbi Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology
    A Iyoda
    Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Chiba, Japan
    Cancer 91:1992-2000. 2001
    ..In 1999, the World Health Organization (WHO) categorized large cell neuroendocrine carcinoma as a variant of large cell carcinoma...
  44. ncbi [Ovarian neuroendocrine carcinoma associated with mucinous carcinoma and teratoma]
    Takeshi Hirasawa
    Department of Obstetrics and Gynecology, School of Medicine, Tokai University, Oiso Hospital
    Nihon Rinsho 62:973-8. 2004
    We experienced two rare case of ovarian neuroendocrine carcinoma (NEC); case 1, NEC associated with mucinous adenocarcinoma and dermoid cyst; case 2, NEC with mucinous cystadenoma...
  45. ncbi Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature
    Jacinthe Chenevert
    Department of Pathology, Centre de recherche clinique et évaluative en oncologie, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Laval University, Quebec, Canada
    Pathol Res Pract 205:657-61. 2009
    Large cell neuroendocrine carcinoma of the ovary is a rare recently established entity. Few cases have been reported in the literature, and they are usually associated with another type of surface epithelial tumor...
  46. ncbi Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus
    Dipen M Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 32:1404-11. 2008
    Clinicopathologic features of esophageal neuroendocrine carcinoma (NEC), apart from those of small-cell carcinoma, have not been characterized...
  47. ncbi Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas
    Satoru Iwasa
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Jpn J Clin Oncol 40:313-8. 2010
    ..However, there were no prior reports limited to the hepatobiliary tract and pancreas as the primary sites...
  48. ncbi Establishment of a new cell line with neuronal differentiation derived from small cell neuroendocrine carcinoma of the maxillary sinus
    Kazuma Noguchi
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Oncology 66:234-43. 2004
    It is well known that small cell neuroendocrine carcinoma (SNEC) arising at extrapulmonary sites has a poor prognosis and an interesting biological characterization...
  49. ncbi Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma
    Akira Iyoda
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    Oncol Rep 11:285-8. 2004
    The World Health Organization (WHO) categorized large cell neuroendocrine carcinoma (LCNEC) as a variant of large cell carcinoma in 1999. However, cytologic features of these tumors have not yet been adequately characterized...
  50. ncbi Management of neuroendocrine differentiated breast carcinoma
    A Berruti
    Oncologia Medica, Department of Clinical and Biological Sciences, University of Torino, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
    Breast 13:527-9. 2004
    ..Surgical resection of metastatic lesions can lead to a durable disease-free status. Serial evaluation of circulating chromogranin A is useful in the follow-up of these patients...
  51. ncbi Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment
    Chigusa Shimono
    Department of Radiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    Int J Clin Oncol 14:351-5. 2009
    Large cell neuroendocrine carcinoma of the gall-bladder is a rare disease in which the prognosis worsens with size...
  52. ncbi Ovarian large cell neuroendocrine carcinoma
    Takahiro Tsuji
    Department of Reproductive Pathophysiology and Obstet Gynecology, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    J Obstet Gynaecol Res 34:726-30. 2008
    Ovarian large cell neuroendocrine carcinoma (LCNC) is a rare disease that is commonly associated with a surface epithelial and germ cell neoplasm component. A 46-year-old woman presented with a pelvic mass measuring 15 cm in diameter...
  53. ncbi Primary small cell neuroendocrine carcinoma of the nasal cavity after successful curative therapy of nasopharyngeal carcinoma: a case report
    Chien Heng Lin
    Department of Medical Education and Research, Jen Ai Hospital Tali, Taichung, Taiwan
    Kaohsiung J Med Sci 25:145-50. 2009
    ..Small cell neuroendocrine carcinoma (SNEC) mainly occurs in the lung, and is rarely found in the head and neck region...
  54. ncbi Large cell/neuroendocrine carcinoma
    Russell Gollard
    Cancer and Blood Specialists of Nevada, 58 N Pecos Road, Henderson, NV 89074, USA
    Lung Cancer 69:13-8. 2010
    ..We review treatment data, and suggest that as in more common types of lung cancer, multi-modality therapy may be the most promising course of treatment...
  55. ncbi Primary extra-ampullary duodenal neuroendocrine carcinoma in an adult male
    Ajay H Bhandarwar
    Department of Surgery, St George s Hospital, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India
    Dig Endosc 21:185-7. 2009
    A primary extra-ampullary duodenal neuroendocrine carcinoma was found in a 40-year-old man who presented with upper abdominal pain and weight loss...
  56. ncbi Primary large-cell neuroendocrine carcinoma of the scrotum
    Anton Maricic
    Department of Urology, Clinical Hospital Center Rijeka, Rijeka, Croatia
    Wien Klin Wochenschr 122:360-2. 2010
    ..2 cm of normal skin. Examination of the specimen revealed a confined poorly differentiated large-cell neuroendocrine carcinoma with a metastasis to the inguinal lymph nodes...
  57. ncbi Primary neuroendocrine carcinoma of thymus: a rare cause of Cushing's syndrome
    Raman Arora
    Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Indian J Pathol Microbiol 53:148-51. 2010
    Thymomas constitute majority of the thymic neoplasms. In contrast, neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) of thymus are extremely rare...
  58. ncbi Loss of cell cohesion in breast cytology as a characteristic of neuroendocrine carcinoma
    Weihua Tang
    Department of Pathology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama, 641 8509 Japan
    Acta Cytol 46:835-40. 2002
    ..To characterize a specific group of breast cancers displaying a scattered single cell pattern in cytology and correlate it with histologic and immunohistochemical findings...
  59. ncbi [A rare case of large cell neuroendocrine carcinoma of the thymus]
    Takahiro Haga
    Department of Respirology, Graduate School of Medicine, Chiba University
    Nihon Kokyuki Gakkai Zasshi 48:755-8. 2010
    ..CT-guided percutaneous tumor biopsy demonstrated large cell neuroendocrine carcinoma of the thymus. He was referred to our hospital in August 2007...
  60. ncbi Gastric collision tumor of large cell neuroendocrine carcinoma and adenocarcinoma--a case report
    Kyu Yun Jang
    Department of Pathology, Institute for Medical Science, Chonbuk National University Medical School, San 2 20 Geumam dong, Deokjin gu, Jeonju City, Jeonbuk 561 180, South Korea
    Pathol Res Pract 206:387-90. 2010
    ..The other lesion was a well-differentiated adenocarcinoma of early gastric cancer type IIa located adjacent mucosa of the main lesion. We diagnosed this lesion as gastric LCNEC concurrent with focal adenocarcinoma, collision type...
  61. ncbi Sinonasal neuroendocrine carcinoma in association with SIADH
    Nilesh R Vasan
    Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, P O Box 26901, WP 1360, Oklahoma City, Oklahoma 73190, USA
    Head Neck 26:89-93. 2004
    b>Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.
  62. ncbi Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case
    So Sen Huang
    Department of Surgery, Taichung Veterans General Hospital, Section 3, 160 Chung Kang Road, Taichung, Taiwan
    Surg Today 36:1032-5. 2006
    Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma. A 59-year-old man was admitted with obstructive jaundice...
  63. ncbi Carcinosarcoma of the parotid gland: an unusual case with large-cell neuroendocrine carcinoma and rhabdomyosarcoma
    T Ueo
    Department of Pathology, Faculty of Medicine, Oita University, Hasama machi, Oita, Japan
    APMIS 113:456-64. 2005
    ..The carcinomatous component consisted of large-cell neuroendocrine carcinoma (LCNEC), squamous cell carcinoma and adenocarcinoma not otherwise specified, while the sarcomatous ..
  64. ncbi Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability
    Michael A Den Bakker
    Department of Pathology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Histopathology 56:356-63. 2010
    To test the hypothesis that the published morphological criteria permit reliable segregation of small cell carcinoma of the lung (SCLC) and large cell neuroendocrine carcinoma (LCNEC) cases by determining the interobserver variation.
  65. ncbi Primary neuroendocrine carcinoma of the liver: an autopsy case
    G Kaya
    Institute of Pathology, University Hospital of Lausanne, Switzerland
    Pathol Int 51:874-8. 2001
    An autopsy case of primary hepatic neuroendocrine carcinoma is described. A 72-year-old man had a large tumor mass measuring 22 cm in its greatest diameter and localized to the right, left and caudal lobes of the non-cirrhotic liver...
  66. ncbi Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients
    Jan Franko
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Gastrointest Surg 14:541-8. 2010
    ..This population-based analysis evaluated the hypothesis that long-term survival benefit is greater with aggressive, rather than limited, surgical therapy...
  67. pmc Gastric neuroendocrine carcinoma arising from heterotopic pancreatic tissue
    R Chetty
    Department of Pathology, University Health Network and University of Toronto, Princess Margaret Hospital, 610 University Avenue, Room 312, Toronto, Ontario M5G 2M9, Canada
    J Clin Pathol 57:314-7. 2004
    ..There was no associated chronic atrophic gastritis or G cell hyperplasia. A discrete focus of high grade neuroendocrine carcinoma (grade 3) within the typical (grade 1) neuroendocrine tumour was also present...
  68. pmc Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report
    M Sironi
    Department of Pathology, Legnano General Hospital, Legnano, Milano, Italy
    J Clin Pathol 55:148-51. 2002
    ..Histology revealed a progression of adenohypophyseal prolactinoma on neuroendocrine carcinoma, with an increase in proliferating indexes and modification of hormone production...
  69. ncbi Large cell neuroendocrine carcinoma of the ovary
    C F Lindboe
    Department of Pathology, Sørlandet Sykehus HF, Kristiansand, Norway
    APMIS 115:169-76. 2007
    Large cell neuroendocrine carcinoma of the ovary is a recently described tumour entity that is now included in the WHO classification of primary ovarian neoplasms...
  70. ncbi Gastric neuroendocrine carcinoma: clinicopathologic review and immunohistochemical study of E-cadherin and Ki-67 as prognostic markers
    Yoon Jung Boo
    Department of Surgery, Korea University College of Medicine, Seoul, Korea
    J Surg Oncol 95:110-7. 2007
    Gastric neuroendocrine carcinoma (NEC) is an uncommon cancer of the stomach. The classification of NEC and its clinical behavior remains controversial, and prognostic markers and their therapeutic guidelines have not been clearly defined...
  71. ncbi Case report: neuroendocrine carcinoma of the gallbladder causing hyperinsulinaemic hypoglycaemia
    J E Ahn
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, Republic of Korea
    Clin Radiol 62:391-4. 2007
  72. ncbi High-grade neuroendocrine carcinoma of the lung: comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma
    Lihua Sun
    Diagnostic Pathology, Gunma University Graduate School of Medicine, National Nishigunma Hospital, Gunma, Japan
    Pathol Int 59:522-9. 2009
    Large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) are high-grade neuroendocrine carcinomas...
  73. ncbi Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 32:719-31. 2008
    ..small cell carcinoma of the gastrointestinal (GI) tract is well-recognized, nonsmall cell type high-grade neuroendocrine carcinoma (HGNEC) of this site remains undefined...
  74. doi Neuroendocrine carcinoma metastatic to the breast
    Helena Hwang
    Department of Pathology, Northwestern University, Chicago, Illinois, USA
    Breast J 14:201-2. 2008
  75. ncbi Small cell/neuroendocrine carcinoma may be a more common phenotype in advanced prostate cancer
    Masahiro Yashi
    Urol Int 69:166-8. 2002
  76. ncbi CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients
    Yasuji Oshiro
    Department of Radiology, University of Ryukyus School of Medicine, 207 Uehara, Nishihara cho, Okinawa Prefecture 903 0215, Japan
    AJR Am J Roentgenol 182:87-91. 2004
    We sought to assess the CT features of surgically resected large cell neuroendocrine carcinoma of the lung.
  77. ncbi Neuroendocrine carcinoma arising within a retroperitoneal mature teratoma
    Alice L Scott
    Department of Surgery, Lister Hospital, Stevenage, Hertfordshire, UK
    Ann R Coll Surg Engl 92:W5-8. 2010
    ..Histological analysis confirmed a mature teratoma of the retroperitoneum with neuroendocrine carcinoma arising within it. To our knowledge this is only the second reported case of its kind.
  78. ncbi [Syndrome of inappropriate antidiuretic hormone secretion disclosing a sinonasal neuroendocrine carcinoma: case report]
    P Rossi
    Service de Médecine Interne de l Hôpital Nord, Chemin des Bourrely, 13105 Marseille France
    Rev Med Interne 28:426-8. 2007
    We report a 74-year-old woman with histologically confirmed neuroendocrine carcinoma of the nasal cavity disclosing a syndrome of inappropriate antidiuretic hormone secretion (SIADH)...
  79. pmc Primary large cell neuroendocrine carcinoma of the breast: radiologic and pathologic findings
    Jin Woo Kim
    Department of Radiology, College of Medicine, Korea University Guro Hospital, Seoul, Korea
    J Korean Med Sci 23:1118-20. 2008
    ..The diagnosis of primary neuroendocrine carcinoma of the breast can only be made if nonmammary sites are confidently excluded or if an in situ component ..
  80. ncbi Thyroid as a target of metastases. A case of foregut neuroendocrine carcinoma with multiple abdominal metastases and a thyroid localization after 21 years
    Franco Mattavelli
    Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:110-3. 2008
    ..e., a medullary thyroid carcinoma. This case report is peculiar because of the multiple sites of abdominal relapses, the long time interval between relapses (21 years), and the positive outcome after surgical treatment...
  81. ncbi Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype
    Neil M Coleman
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg Pathol 30:405-10. 2006
    We describe a case of primary neuroendocrine carcinoma arising from the anterior vaginal wall of a 67-year-old woman. Primary neuroendocrine carcinoma of the vagina is a rare entity with only 25 previously reported cases in the literature...
  82. ncbi Carcinomatous meningitis occurring prior to a diagnosis of large cell neuroendocrine carcinoma of the uterine cervix
    S Kumar
    J Postgrad Med 50:311-2. 2004
  83. ncbi Neuroendocrine carcinoma of the thymus gland with sternal invasion
    Roman Dutta
    Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India
    Interact Cardiovasc Thorac Surg 8:694-6. 2009
    Large-cell neuroendocrine carcinoma of the thymus is a rare cancer that is more aggressive than other thymic epithelial tumors with poorer prognosis...
  84. pmc Metastasis of a caecal neuroendocrine carcinoma to the thyroid gland
    G Papi
    J Clin Pathol 58:1342-3. 2005
  85. ncbi High-grade neuroendocrine carcinoma of the cervix. A case report
    C Baykal
    SSK Ankara Maternity Hospital, Hacettepe University School of Medicine, Ankara, Turkey
    Gynecol Obstet Invest 59:207-11. 2005
    ..As in our case some of the tumors cannot be defined exactly into small or large cell types, and this causes confusion at least for nomenclature purposes. A 'mixed' type for this tumor may be appropriate...
  86. pmc Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube
    Anitha Raghunath
    Department of Ophthalmology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neuroophthalmol 30:252-4. 2010
    ..At 15 months following diagnosis, her ophthalmic status was stable. This is the first report of CAR in neuroendocrine carcinoma of the fallopian tube.
  87. ncbi Neuroendocrine carcinoma of the prostate gland
    Ronald J Cohen
    Pathology 37:326-7. 2005
  88. ncbi Large-cell neuroendocrine carcinoma of the uterine cervix--a clinicopathological study of five cases
    H Rhemtula
    Department of Obstetrics and Gynaecology, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:525-8. 2001
    OBJECTIVE: The present study describes 5 cases of large-cell neuroendocrine carcinoma (LCNEC) of the uterine cervix, evaluating their clinical features and pathological profiles...
  89. ncbi Large-cell neuroendocrine carcinoma of the lung
    Felix G Fernandez
    Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Control 13:270-5. 2006
    Large-cell neuroendocrine carcinoma (LCNEC) of the lung displays morphologic and immunohistochemical characteristics common to neuroendocrine tumors and morphologic features of large-cell carcinomas...
  90. ncbi Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder
    Katsuaki Sato
    Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Pathol Res Pract 206:397-400. 2010
    Large cell neuroendocrine carcinoma (LCNEC) is a high-grade malignant neuroendocrine tumor that was first defined in the lungs...
  91. ncbi Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes
    Tatsuya Okamoto
    J Gastroenterol 38:608-10. 2003
  92. ncbi Large-cell neuroendocrine carcinoma of the uterine cervix complicating pregnancy
    William W H Li
    Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
    Hong Kong Med J 15:69-72. 2009
    ..The patient received concurrent chemotherapy and radiation after termination of pregnancy and remained in complete remission 21 months after completion of treatment...
  93. ncbi Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study
    Massimiliano Paci
    Division of Thoracic Surgery, Department of Pathology, Santa Maria Nuova Hospital, Reggio Emilia, Italy
    Ann Thorac Surg 77:1163-7. 2004
    Large cell neuroendocrine carcinoma is a recently recognized histologic entity whose clinical features and optimal treatment have not yet been well defined and are still being assessed...
  94. ncbi Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases
    Hidefumi Takei
    Clinical Laboratory Division and Thoracic Surgery Division, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    J Thorac Cardiovasc Surg 124:285-92. 2002
    Large cell neuroendocrine carcinoma of the lung is a newly recognized clinicopathologic entity. The clinical characteristics and optimal treatment of patients with large cell carcinomas are not yet established...
  95. ncbi Large cell neuroendocrine carcinoma: an unusual presentation
    Anthony L Estrera
    Department of Cardiovascular Surgery, University of Texas at Houston Medical School, USA
    Ann Thorac Surg 73:1957-60. 2002
    Primary lung cancer presenting as a pulmonary artery mass is unusual. We describe such a presentation in a patient with a large cell neuroendocrine carcinoma of the lung, its evaluation, and its treatment.
  96. ncbi Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 53:111-5. 2006
    Large cell neuroendocrine carcinoma of the lung are considered aggressive. However, reported prognoses are heterogeneous and the optimum treatment remains undefined...
  97. ncbi Large cell neuroendocrine carcinoma of the uterine corpus metastatic to brain and lung: case report and review of the literature
    Y Erhan
    Department of Pathology, Ege University, Faculty of Medicine, Bornova, Izmir, Turkey
    Eur J Gynaecol Oncol 25:109-12. 2004
    b>Neuroendocrine carcinoma of the uterine corpus is a rare aggressive tumor with a similar unfavorable outcome to that of the cervix...
  98. ncbi Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms
    Luoquan Wang
    Department of Pathology, State University of New York, Brooklyn 11202 2098, USA
    Appl Immunohistochem Mol Morphol 10:139-46. 2002
    ..The authors postulate that PTEN is a differentiation marker for NC/NE tissue and tumors and that loss of PTEN expression may represent an important step in the progression of NE tumors...
  99. ncbi Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma
    David Meyronet
    INSERM, U842, Lyon, F 69372, France
    Am J Surg Pathol 32:1699-708. 2008
    ..6% of high-grade neuroendocrine lung tumors, including small cell lung carcinoma and large cell lung neuroendocrine carcinoma, but not in any of the squamous cell carcinomas or lung adenocarcinomas in our series...
  100. ncbi Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum
    A Makino
    Department of Pathology, University Health Network, Princess Margaret Hospital, 610 University Avenue, Fourth Floor, Suite 302, Room 312, Toronto, ON, M5G 2M9, Canada
    Virchows Arch 448:644-7. 2006
    ..a patient who complained of rectal pain and bleeding with a mixed or composite adenocarcinoma and neuroendocrine carcinoma of the rectum...
  101. ncbi Sinonasal neuroendocrine carcinoma: a case report
    Dulani Mendis
    Department of ENT Surgery, Queen s Hospital, Belvedere Rd, Burton upon Trent, Derby DE13 0RB, UK
    Ear Nose Throat J 87:280-2, 293. 2008
    b>Neuroendocrine carcinoma (NEC) is rare. We report a case of probable sinonasal NEC in a 73-year-old man who had presented with a history of right nasal obstruction, nasal discharge, and recurrent epistaxis...

Research Grants7

  1. MOLECULAR GENETICS OF SENSORY ORGAN DEVELOPMENT
    James W Posakony; Fiscal Year: 2013
    ..cancer), medullary thyroid cancer, pheochromocytoma (a tumor of the adrenal medulla), small cell neuroendocrine carcinoma of the prostate, and Merkel cell carcinoma of the skin...
  2. Methyl selenium regulation of Angiogenic switch Mech
    Junxuan Lu; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. Selenium and prostate cancer apoptosis pathways
    Junxuan Lu; Fiscal Year: 2007
    ..The mechanistic insights will help to guide the design of novel Se agents with better efficacy and tolerance and to interpret the results of PCa prevention trials with Se. ..
  4. Multispectral Imaging for Oral Cancer Detection
    Ann Gillenwater; Fiscal Year: 2005
    ..Successful completion of this research will determine the feasibility for MDM imaging as a clinical tool to improve detection and monitoring of oral neoplasia. ..
  5. Paracrine Regulation of IGF-I in the Developing Ileum
    Phillip Gordon; Fiscal Year: 2006
    ..abstract_text> ..
  6. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..This translational study combining the use of radiological and basic science research tools is both necessary and fundamental to firmly lay the groundwork for clinical trials. ..
  7. Transcription Factors in Neuroendocrine Differentiation
    Michael Lan; Fiscal Year: 2009
    ..Results from this study should help us to define the interplay between the IA-1 zinc-finger transcription factor and other neuroendocrine-specific transcription factors in pancreatic endocrine and neuronal development. ..