neuroectodermal tumors

Summary

Summary: Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.

Top Publications

  1. ncbi Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?
    Torsten Ehrig
    Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
    Ann Diagn Pathol 11:153-9. 2007
  2. ncbi Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors
    Agnes S Y Lo
    Division of Surgical Research, Department of Surgery, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Clin Cancer Res 16:2769-80. 2010
  3. ncbi Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
    B Fazi
    Department of Biology, University of Rome Tor Vergata, Rome 133, Italy
    Oncogene 28:3814-24. 2009
  4. ncbi Primitive neuroectodermal tumors of adrenal gland
    Yushi Zhang
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
    Jpn J Clin Oncol 40:800-4. 2010
  5. ncbi Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma
    Mei Hua Li
    Arthur and Sonia Labatt Brain Tumor Research Centre, Cancer Research Program, Division of Hematology and Oncology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada
    Neurosurg Focus 19:E3. 2005
  6. ncbi Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin
    Guido Kohla
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    Neurochem Res 27:583-92. 2002
  7. pmc Detection of N-glycolyl GM3 ganglioside in neuroectodermal tumors by immunohistochemistry: an attractive vaccine target for aggressive pediatric cancer
    Alejandra M Scursoni
    Departament of Pathology, Pediatric Hospital Prof Dr Juan P Garrahan, and Laboratory of Molecular Oncology, Quilmes National University, C1245AAM Buenos Aires, Argentina
    Clin Dev Immunol 2011:245181. 2011
  8. ncbi Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm
    Saeid Movahedi-Lankarani
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, U S A
    Am J Surg Pathol 26:1040-7. 2002
  9. pmc EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations
    M Giovannini
    Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    J Clin Invest 94:489-96. 1994
  10. ncbi High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors
    Alberto Broniscer
    Children s Cancer Group New York University Medical Center, New York, NY, USA
    Pediatr Blood Cancer 42:261-7. 2004

Detail Information

Publications223 found, 100 shown here

  1. ncbi Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?
    Torsten Ehrig
    Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
    Ann Diagn Pathol 11:153-9. 2007
    ..0 years). Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES. These may have a hitherto unrecognized variant genetic abnormality...
  2. ncbi Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumors
    Agnes S Y Lo
    Division of Surgical Research, Department of Surgery, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Clin Cancer Res 16:2769-80. 2010
    ....
  3. ncbi Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
    B Fazi
    Department of Biology, University of Rome Tor Vergata, Rome 133, Italy
    Oncogene 28:3814-24. 2009
    ..These data demonstrate a molecular mechanism by which RTN-1C controls apoptosis and indicate this protein to be a novel potential target for cancer therapy...
  4. ncbi Primitive neuroectodermal tumors of adrenal gland
    Yushi Zhang
    Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
    Jpn J Clin Oncol 40:800-4. 2010
    To analyze the clinical and pathological characteristics of adrenal primitive neuroectodermal tumors for a better understanding of the disease.
  5. ncbi Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma
    Mei Hua Li
    Arthur and Sonia Labatt Brain Tumor Research Centre, Cancer Research Program, Division of Hematology and Oncology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada
    Neurosurg Focus 19:E3. 2005
    The supratentorial primitive neuroectodermal tumors (PNETs) are a group of highly malignant lesions primarily affecting young children...
  6. ncbi Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin
    Guido Kohla
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    Neurochem Res 27:583-92. 2002
    ....
  7. pmc Detection of N-glycolyl GM3 ganglioside in neuroectodermal tumors by immunohistochemistry: an attractive vaccine target for aggressive pediatric cancer
    Alejandra M Scursoni
    Departament of Pathology, Pediatric Hospital Prof Dr Juan P Garrahan, and Laboratory of Molecular Oncology, Quilmes National University, C1245AAM Buenos Aires, Argentina
    Clin Dev Immunol 2011:245181. 2011
    ..Our aim was to evaluate the presence of NeuGc-GM3 in pediatric neuroectodermal tumors by immunohistochemistry...
  8. ncbi Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm
    Saeid Movahedi-Lankarani
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, U S A
    Am J Surg Pathol 26:1040-7. 2002
    Primitive neuroectodermal tumors (PNETs) have rarely been described in solid organs. We report a series of seven PNETs of the pancreas...
  9. pmc EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations
    M Giovannini
    Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    J Clin Invest 94:489-96. 1994
    ..the frequency of EWS fusion transcripts in a series of primary Ewing's sarcomas and peripheral primitive neuroectodermal tumors and cells lines. Type 1 and 2 EWS-Fli1 fusions were demonstrated in 8 cell lines and 14 patient samples...
  10. ncbi High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumors
    Alberto Broniscer
    Children s Cancer Group New York University Medical Center, New York, NY, USA
    Pediatr Blood Cancer 42:261-7. 2004
    Recurrent non-cerebellar primitive neuroectodermal tumors (PNETs) carry a dismal prognosis when treated with conventional chemotherapy alone...
  11. ncbi Ewing sarcoma and sinonasal neuroectodermal tumors as second malignant tumors after retinoblastoma and other neoplasms
    J U Cope
    Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7362, USA
    Med Pediatr Oncol 36:290-4. 2001
    ..To update and advance this information, case reports were sought by an extensive review of the literature...
  12. ncbi Does sophisticated diagnostic workup on neuroectodermal tumors have an impact on the treatment of esthesioneuroblastoma?
    I Haas
    Klinik für HNO Heilkunde, Kopf und Halschirurgie, Universitatsklinikum Dusseldorf, Germany
    Onkologie 26:261-7. 2003
    ..We have investigated whether improvements in diagnosis of sinonasal neuroectodermal tumors, including esthesioneuroblastomas (ENB), sinonasal neuroendocrine carcinomas (SNEC) and sinonasal ..
  13. ncbi Gastrointestinal neuroendocrine/neuroectodermal tumors
    C M Fenoglio-Preiser
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, OH 45267-0529, USA
    Am J Clin Pathol 115:S79-93. 2001
    ..Tumor arrays within a given site, as in the stomach, are compared with one another to highlight their histologic features and differing biologies. General treatment guidelines are also provided...
  14. pmc Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors
    Hyunsuk Shim
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    Semin Cancer Biol 19:123-34. 2009
    ..As an attractive therapeutic target of CXCR4/CXCL12 axis for cancer chemotherapy, development history and application of CXCR4 antagonists are described...
  15. ncbi Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescue
    Thomas Lehrnbecher
    Department of Pediatric Hematology, Johann Wolfgang University of Frankfurt, Germany
    Pediatr Infect Dis J 25:465-6. 2006
    ..No other site of invasive aspergillosis was evident. The patient was successfully treated with early surgery and combination antifungal therapy...
  16. ncbi [Tumors of the central nervous system in children in the Republic of Belarus: morbidity and survival on a population level]
    S V Petrovich
    Vopr Onkol 48:306-10. 2002
  17. ncbi Molecular analysis of pediatric brain tumors
    Jaclyn A Biegel
    Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 6:445-52. 2004
    ..Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment...
  18. ncbi Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 65:210-21. 2006
    ..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
  19. ncbi Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91
    Beate Timmermann
    Department of Radiooncology, and Institute of Medical Information Processing, University of Tubingen, Tubingen, Germany
    J Clin Oncol 20:842-9. 2002
    To evaluate the outcome of children with supratentorial primitive neuroectodermal tumors after surgery, irradiation, and chemotherapy and to identify factors predictive for survival.
  20. ncbi MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration
    Satoshi O Suzuki
    Division of Neuropathology, Columbia University College of P and S, New York, New York, USA
    J Neuropathol Exp Neurol 61:403-12. 2002
    ..MAP-2e was not expressed in non-CNS tumors or neuroblastomas. Thus. neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia...
  21. ncbi Recent advances in paediatric neuro-oncology
    Frank Saran
    Department of Radiotherapy, Royal Marsden Hospital NHS Trust, Sutton, Surrey, UK
    Curr Opin Neurol 15:671-7. 2002
    ..Over the last 12-18 months a significant number of institutional and national studies have been reported which are likely to impact on the design of future clinical trials...
  22. ncbi A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study
    Maryam Fouladi
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Cancer 110:2535-41. 2007
    ....
  23. pmc Generating prior probabilities for classifiers of brain tumours using belief networks
    Greg M Reynolds
    Department of Electrical, Electronic and Computer Engineering, University of Birmingham, Birmingham, UK
    BMC Med Inform Decis Mak 7:27. 2007
    ..g. combining imaging information with spectroscopy. In this work a method of generating probabilities of tumour class from anatomical location is presented...
  24. ncbi High-dose chemotherapy in childhood brain tumors
    J E A Wolff
    Abteilung Pädiatrische Hämatologie und Onkologie, Krankenhaus Barmherzige Brüder, Klinik St Hedwig, Regensburg, Germany
    Onkologie 27:239-45. 2004
    ..The data suggest benefit in recurrent primitive neuroectodermal tumors (PNET), in newly diagnosed young children with PNET and possibly in young children with newly diagnosed ..
  25. ncbi [Supratentorial primitive neuroectodermal tumor: a single center experience and comparison with the literature]
    I Schmid
    Kinderklinik und Kinderpoliklinik im Dr von Haunerschen Kinderspital, Ludwig Maximilians Universitat Munchen
    Klin Padiatr 217:153-7. 2005
    Supratentorial primitive neuroectodermal tumors (stPNETs) are malignant tumors. We saw within three years six children with stPNETs. In four of the six children radical resection could be achieved...
  26. ncbi Fetal growth and the risk of childhood CNS tumors and lymphomas in Western Australia
    Elizabeth Milne
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
    Int J Cancer 123:436-43. 2008
    ..The associations we observed are consistent with causal pathways involving fetal growth factors...
  27. ncbi Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor
    Arnold C Paulino
    Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA
    Int J Radiat Oncol Biol Phys 58:1171-6. 2004
    ..Supratentorial primitive neuroectodermal tumor (PNET) accounts for 2-3% of all pediatric brain tumors. We retrospectively reviewed all supratentorial PNET cases treated with radiotherapy (RT) at our institutions...
  28. pmc A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas
    C De Bustos
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
    J Med Genet 42:31-7. 2005
    ..The molecular mechanisms responsible for the PDGFRalpha expression in tumours are not known, but in the absence of amplification, changes in transcriptional regulation might be an important factor in this process...
  29. ncbi Dysembryoplastic neuroectodermal tumor: an ultrastructural study of six cases
    W Biernat
    Department of Tumor Pathology, , Poland
    Ultrastruct Pathol 25:455-67. 2001
    ..The authors conclude that OLC exhibit clear-cut characteristics of neuronal cells and not true oligodendocytes...
  30. ncbi Malignant ectomesenchymoma of the cerebrum. Case report and discussion of therapeutic options
    Elisabeth Weiss
    Department of Radiotherapy and Radiooncology, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Eur J Pediatr 164:345-9. 2005
    ..Therapy was tolerated well without any severe side effects. Six years from diagnosis, the patient is alive without a tumour relapse...
  31. ncbi Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopy
    Tina Young Poussaint
    Department of Radiology, Harvard Medical School, Boston, MA, USA
    Neuroimaging Clin N Am 16:169-92, ix. 2006
    ..These techniques are complementary to conventional MR imaging in providing tumor physiologic information useful for diagnosis and therapy...
  32. ncbi [Cytopathology of malignant blastematous tumors]
    Philippe Vielh
    Institut Gustave Roussy Département de Pathologie, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Ann Pathol 24:568-73. 2004
    ....
  33. ncbi Boost Gamma Knife surgery during multimodality management of adult medulloblastoma
    Anand V Germanwala
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 108:204-9. 2008
    ..The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation...
  34. ncbi [Successful treatment with caspofungin of an invasive candidosis resistant to liposomal amphotericin B in a neutropenic patient]
    A Rome
    Arch Pediatr 13:1556-7. 2006
  35. ncbi Preliminary results of dose intensive pre-irradiation chemotherapy in patients older than 10 years of age with high risk medulloblastoma and supratentorial primitive neuroectodermal tumors
    Kavita Dhodapkar
    New York University Medical Center, New York, NY, USA
    Med Pediatr Oncol 38:47-8. 2002
  36. ncbi Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studies
    W Papierz
    Department of Pathological Anatomy, Medical Academy Lodz, Poland
    Ultrastruct Pathol 19:147-66. 1995
    ..of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs)...
  37. pmc Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome
    Michel De Vos
    Molecular Medicine Unit, University of Leeds, Leeds LS9 7TF, United Kingdom
    Am J Hum Genet 74:954-64. 2004
    ..For technical reasons, their involvement in childhood cancer, particularly in primitive neuroectodermal tumor, may have been underestimated...
  38. ncbi Imatinib mesylate (STI571) interference with growth of neuroectodermal tumour cell lines does not critically involve c-Kit inhibition
    Geertuy Te Kronnie
    Department of Pediatrics, University of Padova, 35128 Padova, Italy
    Int J Mol Med 14:373-82. 2004
    A therapeutic role of STI571 (imatinib mesylate) has been anticipated in patients with c-Kit positive neuroectodermal tumors. We examined the efficacy of STI571 to inhibit expansion of c-Kit positive neuroectodermal tumor cell lines in ..
  39. ncbi Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148, Genoa, Italy
    Ann N Y Acad Sci 1028:90-103. 2004
    b>Neuroectodermal tumors are highly malignant and increasingly common tumors. Because the cure rate of these neoplasias by conventional treatment is very low, new therapeutic approaches are needed...
  40. pmc Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57
    M Corazzari
    1INMI IRCCS Lazzaro Spallanzani, Rome 00149, Italy
    Br J Cancer 96:1062-71. 2007
    ..Therefore, ER-resident proteins such as ERdj5 and ERp57 may represent novel chemotherapeutic targets...
  41. ncbi Drug delivery systems: application of liposomal anti-tumor agents to neuroectodermal cancer treatment
    Daniela Di Paolo
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Tumori 94:246-53. 2008
    ..The most multifunctional targeted liposomes are herein described, with primary attention on testing their efficacy in clinically relevant animal models for the treatment of neuroblastoma and melanoma...
  42. ncbi Comparative study using rabbit-derived polyclonal, mouse-derived monoclonal, and rabbit-derived monoclonal antibodies for KIT immunostaining in GIST and other tumors
    Masako Saito
    Department of Tumor Pathology, Graduate School of Medicine, Gunma University, Gunma, Japan
    Pathol Int 57:200-4. 2007
    ..At present, pAb A4502 or RabMA Y145 seems to be suitable for KIT immunostaining in formalin-fixed paraffin-embedded tumor specimens, especially in the differential diagnosis of GIST from other mesenchymal tumors...
  43. ncbi Posttransplant adoptive immunotherapy with interleukin-2 in children suffering from neuroectodermal tumors with poor prognosis
    K Kałwak
    Department of Pediatric Hematology and Oncology, Medical University of Wrocław, 44 Bujwida Street, 50 345 Wrocław, Poland
    Transplant Proc 34:665-7. 2002
  44. ncbi Guidelines for radioiodinated MIBG scintigraphy in children
    Pierre Olivier
    CHU Nancy, France
    Eur J Nucl Med Mol Imaging 30:B45-50. 2003
    ..The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations...
  45. ncbi Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms
    Yulin Liu
    Department of Pathalogy and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Adv Anat Pathol 10:101-6. 2003
    ..This report details the diagnostic value of MAP-2 on tumors with neuroendocrine differentiation and neoplasms derived from the neural crest...
  46. ncbi Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous system
    A Taraszewska
    Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw
    Folia Histochem Cytobiol 40:207-8. 2002
    ....
  47. ncbi Pigmented intraosseous odontogenic carcinoma of the maxilla: a pediatric case report and differential diagnosis
    R Ijiri
    Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan
    Hum Pathol 32:880-4. 2001
    ..We consider that the present tumor suggests a close association of ectoderm, mesenchyma, and neuroectoderm in embryogenesis of the tooth, and can raise a diagnostic confusion with melanotic neuroectodermal tumor...
  48. ncbi A rare primitive neuroectodermal tumour presenting unusually in a postmenopausal woman
    J Doshi
    Department of Obstetrics and Gynaecology, Hemel Hempstead General Hospital, UK
    J Obstet Gynaecol 23:684-5. 2003
  49. ncbi Cerebral primitive neuroectodermal tumour in a heifer
    M N Lucas
    Unité d Anatomie Pathologique, Ecole Nationale Veterinaire de Nantes, Atlanpole, La Chantrerie, BP 40706 F 44307, Nantes Cedex 03, France
    J Comp Pathol 128:195-8. 2003
    ..Immunolabelling was positive for vimentin and neuron-specific enolase, in agreement with previous reports of PNETs in human beings and animals. This appears to be the first report of cerebral PNET in cattle...
  50. ncbi Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes
    Sabine Spiegl-Kreinecker
    Department of Neurosurgery, Landesnervenklinik Wagner Jauregg Hospital, Linz, Austria
    J Neurooncol 57:27-36. 2002
    ..and multidrug-resistance protein 1 (MRP1) in cell lines (N = 24) and primary cell cultures (N = 36) from neuroectodermal tumors, as well as in brain tumor extracts (N = 18) and normal human astrocytes (N = 1)...
  51. ncbi Perioperative headaches in an adolescent: a most complex situation
    Rafael Campanini
    Department of Anesthesiology Pain Management, The Children s Hospital and University of Colorado Health Sciences Center, 1056 East 19th Avenue, B090, Denver, CO 80218, USA
    J Adolesc Health 34:535-9. 2004
  52. ncbi Serum and CSF immunoglobulins G, A and M in 37 intracranial tumors
    K Dawani
    Department of Pathology, Dow Medical College, Karachi
    J Pak Med Assoc 52:549-53. 2002
    ..To estimate different proteins and immunoglobulins as humoral immune response in patients with intracranial tumours...
  53. ncbi Rapid increase in volume of multiple tumor cysts after intracranial pressure reduction
    Yoshio Taguchi
    Division of Neurosurgery, St Marianna University Yokohama City Seibu Hospital, Yokohama, Japan
    Pediatr Neurosurg 42:132-3. 2006
  54. ncbi 40 year-old male with history of brain tumor 10 years ago
    Atik Baborie
    Department of Neuropathology, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain Pathol 17:337-9. 2007
  55. ncbi Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin?
    Martina M Uttenreuther-Fischer
    Charite, Hochschulmedizin Berlin, Campus Virchow Klinikum, Children s Hospital, Dept General Pediatrics, Germany
    J Immunol 176:7775-86. 2006
    ..18. Rabbits vaccinated with GK8 or GK2 (weaker) produced Ab3 against the original target Ag GD2. GK8 may be useful as a tumor vaccine for GD2-positive [corrected] tumors...
  56. pmc Targeted expression of MYCN causes neuroblastoma in transgenic mice
    W A Weiss
    G W Hooper Foundation, and Department of Neurology, University of California, San Francisco 94143 0552, USA
    EMBO J 16:2985-95. 1997
    ....
  57. pmc Gangliosides inhibit the development from monocytes to dendritic cells
    M Wolfl
    Department of Paediatric Oncology and Hematology, Children s Hospital, University of Cologne, Germany
    Clin Exp Immunol 130:441-8. 2002
    ..Suppression was induced by GM2, but not by the other gangliosides. These data suggest that certain gangliosides impair DC precursors, implying a possible mechanism for tumour escape...
  58. ncbi Fine-needle aspiration of adult small-round-cell tumors studied with flow cytometry
    Marino E Leon
    Department of Pathology and Laboratory Medicine, Drexel University, College of Medicine, Philadelphia, Pennsylvania 15212, USA
    Diagn Cytopathol 31:147-54. 2004
    ..ES/PNET in FNA and BMA can be efficiently and rapidly diagnosed by combining cytologic examination with FCI using a panel including CD45, CD16/56, and CD99...
  59. ncbi Automated nuclear image morphometry on fine needle aspiration smears of malignant round cell tumors
    U Brahmi
    Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Anal Quant Cytol Histol 23:287-90. 2001
    ..It was possible to differentiate WT and NHL with ICM. Nuclear ICM was not significantly different in the NB, PNET and ES groups, and probably ICM would not be very helpful to differentiate these groups of MRCT...
  60. ncbi Nerve growth factor regulates neuroectodermal tumor cell responses to mitogenic growth factors
    Raquel Castellon
    Department of Ophthalmology, University of California Irvine, USA
    J Neurosci Res 72:239-49. 2003
    ..These results suggest that NGF could exert similar actions on cellular responses to growth factors in vivo...
  61. ncbi Marrying pediatric oncology to biological research: cell communication in neuroectodermal tumors: introduction to the workshop
    Luisa M E Massimo
    Pediatric Hematology and Oncology Unit G Gaslini, Scientific Children s Hospital, 16147 Genova, Italy
    Ann N Y Acad Sci 1028:56-8. 2004
  62. ncbi Characteristics and outcome of children with primary soft tissue sarcomas of extremities
    Joanna Zawitkowska-Klaczyńska
    Department of Peadiatric Haematology and Oncology, Medical University, Chodzki 2 St, Lublin, Poland
    Med Wieku Rozwoj 8:169-74. 2004
    ..To determine the characteristics and outcome or patients with primary soft tissue sarcomas of extremities in children...
  63. ncbi Morphologic characterization of spontaneous nervous system tumors in mice and rats
    G J Krinke
    Toxicology Department, Novartis Crop Protection AG, Stein, Switzerland
    Toxicol Pathol 28:178-92. 2000
    ..Primitive neuroectodermal tumors of rats, such as pineal tumors or medulloblastomas, appear to have features similar to those found in man...
  64. ncbi Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations
    K Devaney
    Department of Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC
    Hum Pathol 24:1211-25. 1993
    ..rather appeared in some small cell osteosarcomas, Ewing's sarcomas, atypical Ewing's sarcomas, primitive neuroectodermal tumors, mesenchymal chondrosarcomas, lymphomas, and Askin tumors...
  65. ncbi Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors
    R T Woodburn
    Department of Radiation Oncology, Indiana University Medical Center, Indianapolis 46202, USA
    J Neurooncol 52:57-62. 2001
    ..Intense p53 immunostaining may predict for a poor prognosis in central nervous system primitive neuroectodermal tumor of childhood...
  66. ncbi Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitrosourea-based chemotherapy
    M D Prados
    Department of Neurosurgery, University of California, San Francisco, USA
    Pediatr Neurosurg 25:174-81. 1996
    ..PFS) of children and adults with newly diagnosed medulloblastoma, pineoblastoma, and other primitive neuroectodermal tumors (PNET) with a combined modality regimen of radiation therapy and adjuvant nitrosourea-based chemotherapy.
  67. ncbi Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study group
    S Stegmaier
    Olgahospital, Stuttgart, Germany
    Klin Padiatr 216:315-22. 2004
    ..of about 80-90 % of Ewing's sarcoma family of tumors [bone and soft tissue Ewing's sarcoma and peripheral neuroectodermal tumors (PNET)]. They generate ews/fli1 rearrangements showing great diversity in breakpoint exon combination...
  68. ncbi Foreign body reaction to hemostatic materials mimicking recurrent brain tumor. Report of three cases
    K F Kothbauer
    Department of Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
    J Neurosurg 95:503-6. 2001
    ..All patients were boys (3, 3, and 6 years of age, respectively) and all harbored primitive neuroectodermal tumors. Two tumors were located in the posterior fossa and one was located in the right parietal lobe...
  69. ncbi Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study
    Martin Benesch
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria
    Anticancer Drugs 20:794-9. 2009
    ..refractory medulloblastoma (n = 12), mixed germ cell tumor (n = 2), central nervous system primitive neuroectodermal tumors of the pons (n = 1), anaplastic ependymoma (n = 1), anaplastic oligodendroglioma (n = 1), atypical ..
  70. ncbi Expression of MYCN in pediatric synovial sarcoma
    Gino R Somers
    Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Mod Pathol 20:734-41. 2007
    ..sarcomas and 29 other sarcomas (four malignant peripheral nerve sheath tumors, 15 Ewing sarcoma/primitive neuroectodermal tumors, 10 undifferentiated sarcomas) were examined for MYCN expression and gene amplification...
  71. ncbi Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice
    K M Fung
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia
    Lab Invest 70:114-24. 1994
    ..Two of the four lines developed primitive neuroectodermal tumors (PNETs) in the brain stem or pineal gland...
  72. ncbi Recent advances in pediatric renal neoplasia
    Pedram Argani
    The Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 10:243-60. 2003
    ..Primary renal synovial sarcomas and renal primitive neuroectodermal tumors have become accepted entities, and likely comprise a subset of what had previously been termed "adult ..
  73. ncbi Renal tumors in children aged 10-16 Years: a report from the United Kingdom Children's Cancer and Leukaemia Group
    Sergey D Popov
    Department Paediatric Oncology, The Institute of Cancer Research, London, UK
    Pediatr Dev Pathol 14:189-93. 2011
    ..6%), 10 (14.9%) renal cell carcinomas, 3 (4.5%) renal medullary carcinomas, 2 (3%) primitive neuroectodermal tumors, 1 clear cell sarcoma of kidney, and 1 desmoplastic small round cell tumor...
  74. ncbi Molecular genetic study of a metastatic oligodendroglioma
    M T Giordana
    Department of Neuroscience, University of Turin, Turin, Italy
    J Neurooncol 66:265-71. 2004
    Extracranial spread of neuroectodermal tumors is an unusual event, most frequently expected from glioblastomas and medulloblastomas. Single cases of metastatic oligodendrogliomas have been described, but no genetic data are reported...
  75. ncbi A general aspect on soft-tissue sarcoma and c-kit expression in primitive neuroectodermal tumor and Ewing's sarcoma. Is there any role in disease process?
    Ismail O Kara
    Department of Medical Oncology, Faculty of Medicine, Cukurova University, 01330, Adana, Turkey
    Saudi Med J 26:1190-6. 2005
    Within soft-tissue sarcoma, primitive neuroectodermal tumors have been shown to cover a wide spectrum of small round cell sarcomas, including Ewing's sarcomas (ES) and primitive neuroectodermal tumors (PNET)...
  76. ncbi Central nervous system tumors in patients under three years of age: treatment results of a single institute
    Ali Varan
    Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey
    Pediatr Neurosurg 42:89-94. 2006
    ..medulloblastoma, 4 ependymoblastoma, 5 with atypical teratoid rhabdoid and 2 with supratentorial primitive neuroectodermal tumors), 21 (24.4%) with ependymoma, 14 (16.3%) with optic glioma, 10 (11.6%) with astrocytoma, 3 (3...
  77. ncbi Significant differences in the matrix metalloproteinase expression profiles of spontaneous medulloblastomas/primitive neuroectodermal tumors as compared with their xenografted, established tumor cell line derived counterparts
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles, CA, USA
    In Vivo 14:675-82. 2000
    ..cells derived from an established cell-line [DAOY#3]) childhood medulloblastomas (MEDs)/primitive neuroectodermal tumors (PNETs) employing an indirect alkaline phosphatase conjugated immunocytochemical technique...
  78. ncbi The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide
    E R Lawlor
    Department of Pathology, British Columbia s Children s Hospital, Vancouver, Canada
    Cancer Res 58:2469-76. 1998
    The Ewing tumor family of peripheral primitive neuroectodermal tumors (pPNETs) are characterized by chromosomal translocations leading to EWS-ETS gene fusions...
  79. ncbi Identification of novel biomarkers in pediatric primitive neuroectodermal tumors and ependymomas by proteome-wide analysis
    Judith M de Bont
    Department of Pediatric Oncology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 66:505-16. 2007
    The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas...
  80. ncbi Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
    Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial.
  81. ncbi Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 cases
    Amir Behdad
    Department of Pathology, Cedar Sinai Medical Center, Los Angeles, Calif, USA
    Brain Pathol 20:441-50. 2010
    Central nervous system (CNS) primitive neuroectodermal tumors (PNETs) include supratentorial, brain stem, and spinal cord tumors with medulloblastoma-like histopathology...
  82. ncbi Surgical treatment and prognosis of primitive neuroectodermal tumors of the thorax
    Adalet Demir
    Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul University, Istanbul, Turkey
    J Thorac Oncol 4:185-92. 2009
    Primitive neuroectodermal tumors (PNETs) are rare, rapidly progressive, small- round cell tumors with a poor prognosis despite multimodal therapy, including surgery and chemoradiotherapy...
  83. ncbi A fourth ventricle atypical teratoid/rhabdoid tumor in an infant
    Chikanori Inenaga
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Brain Tumor Pathol 20:47-52. 2003
    ..nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis...
  84. ncbi Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results
    Dawn Elizabeth McNeil
    Division of Cancer Epidemiology and Genetics, NCI NIH EPS, Rockville, Maryland 20892 7236, USA
    Med Pediatr Oncol 39:190-4. 2002
    It has been suggested that cerebellar medulloblastoma (M) and primitive neuroectodermal tumors (PNET) arising elsewhere in the nervous system, represent a single entity (M/PNET), although this concept is controversial...
  85. ncbi Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in childhood medulloblastomas/primitive neuroectodermal tumors
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles 91335, USA
    Anticancer Res 20:1769-80. 2000
    ..The value of these genes and proteins in the early diagnosis and possible treatment of various human neoplasms, including childhood brain tumors, should be assessed in further immunocytochemical and molecular biological experiments...
  86. ncbi Telomerase activity and alterations in telomere length in human brain tumors
    S Hiraga
    Department of Neurosurgery, Osaka University Medical School, Suita, Japan
    Cancer Res 58:2117-25. 1998
    ..High telomerase activity was exhibited in all primitive neuroectodermal tumors, anaplastic oligoastrocytomas, neuroblastomas, and oligodendrogliomas...
  87. ncbi Impact of high-dose busulfan plus melphalan as consolidation in metastatic Ewing tumors: a study by the Société Française des Cancers de l'Enfant
    Odile Oberlin
    Department of Paediatric Oncology, Institut Gustave Roussy, rue Camille Desmoulins, Villejuif, France
    J Clin Oncol 24:3997-4002. 2006
    To improve the prognosis for patients with metastatic Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) using conventional chemotherapy and consolidation high-dose chemotherapy (HDCT) containing busulfan and melphalan.
  88. ncbi The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma
    Erinn Downs-Kelly
    Department of Anatomic, Cleveland Clinic, Cleveland, OH 44195, USA
    Diagn Mol Pathol 18:138-43. 2009
    ..n = 8), neuroblastoma (n = 1), desmoplastic small round cell tumors (n = 2), Ewing sarcoma/primitive neuroectodermal tumors (EWS/PNET; n = 15), and round cell liposarcoma (n = 1)...
  89. ncbi Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report
    H J Girschick
    University of Wurzburg, Children s Hospital, Germany
    Pathol Oncol Res 7:67-71. 2001
    Primitive neuroectodermal tumors (PNET) represent about 25% of primary central nervous system tumors in childhood, but congenital PNETs are rare...
  90. ncbi Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature
    Elizabeth D Euscher
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 32:219-28. 2008
    Uterine tumors with neuroectodermal differentiation, frequently referred to as primitive neuroectodermal tumors (PNETs), are uncommon. The clinicopathologic features of 17 such cases reviewed at the M.D...
  91. ncbi Transverse myelitis after therapy for primitive neuroectodermal tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Pediatr Neurol 35:122-5. 2006
    Traditional therapy for malignant primitive neuroectodermal tumors in children includes surgery, multi-agent chemotherapy, and radiation...
  92. pmc Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus
    Charles G Eberhart
    Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
    BMC Cancer 5:19. 2005
    ..We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined...
  93. ncbi Ataxia-telangiectasia: atypical presentation and toxicity of cancer treatment
    Rochelle A Yanofsky
    Section of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, MB, Canada
    Can J Neurol Sci 36:462-7. 2009
    ....
  94. ncbi ATM gene mutations are not involved in medulloblastoma in children
    Ella Liberzon
    Molecular Oncology, Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
    Cancer Genet Cytogenet 146:167-9. 2003
    Primitive neuroectodermal tumors (PNET)-medulloblastomas account for approximately 20% of all brain tumors in children. Ataxia-telangiectasia is an autosomal recessive neurological disorder with predisposition to cancer...
  95. pmc Familial posterior fossa brain tumors of infancy secondary to germline mutation of the hSNF5 gene
    M D Taylor
    Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Am J Hum Genet 66:1403-6. 2000
    ..tumors of infancy, including central nervous system (CNS) malignant rhabdoid tumor (a subset of primitive neuroectodermal tumors, or PNET) and choroid plexus carcinoma...
  96. ncbi Midline brain tumors in MSV-SV 40-transgenic mice originate from the pineal organ
    W Gotz
    Zentrum Anatomie, Abteilung Histologie, Universitat Gottingen, Federal Republic of Germany
    Acta Neuropathol 83:308-14. 1992
    ..and the SV 40 promoter develop inheritable uniform midline brain neoplasms showing features of primitive neuroectodermal tumors. The origin and histogenesis of these tumors were investigated in the present study...
  97. ncbi Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors
    A Pagani
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Diagn Mol Pathol 1:165-72. 1992
    ..blotting and in situ hybridization) in primary lesions and cell lines of Ewing's sarcomas, primitive neuroectodermal tumors (PNETs), and neuroblastomas...
  98. ncbi The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains
    T Ohno
    Department of Microbiology and Immunology, Jefferson Cancer Institute, Philadelphia, PA 19107 5541
    Oncogene 9:3087-97. 1994
    ..22, is involved in a wide variety of human solid tumors including Ewing sarcoma, related primitive neuroectodermal tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors...
  99. ncbi Maternal medication use and the risk of brain tumors in the offspring: the SEARCH international case-control study
    Amanda H Cardy
    Department of Public Health, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Int J Cancer 118:1302-8. 2006
    ..Analysis was conducted for all participants combined, by tumor type (astroglial, primitive neuroectodermal tumors and other glioma), and by age at diagnosis (< or =5 years; >5 years)...
  100. ncbi Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology
    T W Smith
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655
    Clin Neuropathol 12:335-42. 1993
    ..Primitive neuroectodermal tumors (PNETs) (cerebral PNET, medulloblastoma, neuroblastoma) and most neuroendocrine tumors generally showed ..
  101. pmc INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors
    Hong Wei Wang
    Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Hum Gene Ther 20:1308-18. 2009
    ..an adenoviral INSM1 promoter-driven herpes simplex virus thymidine kinase (HSV-tk) construct in primitive neuroectodermal tumors (PNETs). We constructed an adenoviral INSM1 promoter-driven HSV-tk gene for therapy in PNETs...

Research Grants44

  1. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    Medulloblastomas, which belong to a group of primitive neuroectodermal tumors, are invasive tumors with predominant neuronal differentiation...
  2. Pesticide Exposure and Childhood Cancer Study
    Beate R Ritz; Fiscal Year: 2012
    ..acute myeloid leukemia, acute lymphoblastic leukemia, non Hodgkin lymphoma, astrocytoma, primitive neuroectodermal tumors, Wilms tumor, soft tissue sarcomas) and population-based controls...
  3. The role of Id proteins in tumor development and angiogenesis in the brain
    Anna Lasorella; Fiscal Year: 2013
    ..Given the pervasive and aggressive nature of the "angiogenic switch" in neuroectodermal tumors and its dependency on Id expression, we have focused on this cellular system...
  4. 'Exvading'Invasive Pediatric Brain Tumors
    Ravi V Bellamkonda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Medulloblastomas are highly invasive primitive neuroectodermal tumors of the cerebellum and the most common childhood malignant brain tumor, constituting 20-40% of pediatric brain tumors...
  5. Role of gangliosides in tumor progression
    Stephan Ladisch; Fiscal Year: 2012
    Tumor progression, and particularly that of some neuroectodermal tumors (e.g., neuroblastoma and melanoma) causes most cancer-related morbidity and mortality...
  6. Clinical pharmacology of cyclophosphamide in pediatric medulloblastoma patients
    Michael B Tagen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Medulloblastoma and primitive neuroectodermal tumors (PNETs) are childhood brain tumors where about 40% of patients die due to early tumor recurrence...
  7. OPENING OF THE BLOOD-BRAIN BARRIER TO ANTITUMOR AGENTS
    Edward A Neuwelt; Fiscal Year: 2013
    ..for enhancing chemotherapy dose intensity for intracerebral medulloblastoma as a model of primitive neuroectodermal tumors within brain parenchyma, by using BBBD and by depleting glutathione stores in conjunctions with thiol ..
  8. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
    ..By using the early genome of JCV, we have created transgenic animals that develop cerebellar primitive neuroectodermal tumors with extraordinary similarity to human medulloblastoma...
  9. Academic Public Private Partnership Program
    M O DORISIO; Fiscal Year: 2004
    ..tumors seen in adults, pediatric neuroendocrine tumors thus include neuroblastoma and primitive neuroectodermal tumors (PNET) such as medulloblastoma, supratentorial PNET and the Ewings sarcoma family of tumors...
  10. MOLECULAR ANALYSIS OF PEDIATRIC CANCERS
    Giovanni Rovera; Fiscal Year: 1993
    ..Project 3 will identify and characterize NGF induced immediate-early genes in primitive neuroectodermal tumors which are incompetent to trans activity other genes whose expression is required for terminal ..
  11. CHLORIDE CHANNELS: NOVEL TARGETS FOR CANCER TREATMENT
    Susan Lyons; Fiscal Year: 2000
    The prognosis for highly invasive peripheral neuroectodermal tumors (PNETs) is discouraging with the current standard of care treatments...
  12. PHASE I/II TRIAL, INTRACAVITARY LAK/IL-2 IN BRAIN TUMORS
    Maxim Koslow; Fiscal Year: 1991
    The prognosis of patients with malignant neuroectodermal tumors is poor despite radiation and chemotherapy. Alternative approaches to cancer therapy have focused on the use of biological response modifiers (BRMs) as antitumor agents...
  13. PRIMITIVE NEUROECTODERMAL TUMORS OF CHILDHOOD
    Peter Phillips; Fiscal Year: 2000
    Medulloblastoma (MB) and related CNS primitive neuroectodermal tumors (PNETs) are the most common pediatric malignant brain tumors and major source of neurological morbidity and mortality in children...
  14. CELL DEATH AND DIFFERENTIATION IN MEDULLOBLASTOMA
    John Trojanowski; Fiscal Year: 1999
    Medulloblastomas (MBs) are prototypical primitive neuroectodermal tumors (PNETs) of the cerebellum, and they are among the most common pediatric brain tumors...
  15. RECESSIVE TUMOR GENES IN NEUROECTODERMAL MALIGNANCIES
    NICHOLAS DRACOPOLI; Fiscal Year: 1990
    As is the case with many human cancers, neuroectodermal tumors including melanoma and neuroblastoma are characterized by specific karyotypic abnormalities...
  16. SONIC HEDGEHOG/PTCH PATHWAY IN PNET
    Corey Raffel; Fiscal Year: 2000
    ..Primitive neuroectodermal tumors are the most common of these. Using best available therapy, 5 year survival for children with PNET is 60%...
  17. MOLECULAR PROFILES OF SMALL CELL LUNG CARCINOMA ANTIGENS
    John Harper; Fiscal Year: 1991
    ..capitalizing on monoclonal antibodies that recognize a 100 kDa glycoprotein secreted by SCCL and by other neuroectodermal tumors, and a sulfated, 90 kDa cell surface phospho-glycoprotein strongly associated with SCCL that may lead to a ..
  18. MOLECULAR PROFILE OF MELANOMA AND NEUROBLASTOMA ANTIGENS
    Holger Lode; Fiscal Year: 2000
    ..approaches that will reduce the rate of tumor cell dissemination in spontaneous metastasis models of neuroectodermal tumors. Major hypotheses to be tested are that either immunotherapy modalities designed to activate immune ..
  19. GSK-3Beta and Associated Pathways in PNET
    Corey Raffel; Fiscal Year: 2004
    Primitive neuroectodermal tumors (PNET) are the most common malignant brain tumor of childhood. Using best available therapy, five-year survival for children with PNET is 60%...
  20. Role of L1-CAM in Melanoma Progression and Agiogenesis
    Anthony Montgomery; Fiscal Year: 2007
    ..L1 (or L1-CAM) is a neural cell adhesion molecule that is overexpressed in neuroectodermal tumors. In malignant melanoma, L1-expression correlates with the development of metastatic disease...
  21. Mammalian genetic analysis of embryonic neural overgrow*
    Karen Artzt; Fiscal Year: 2006
    ..It is expected that this set of genes will define a new tumor suppressor that plays-a role in the development of primitive neuroectodermal tumors of children.
  22. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  23. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  24. TGF BETA AND BRAIN TUMORS
    Jeremy Rich; Fiscal Year: 2002
    ....
  25. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  26. Actions of Estrogen & Environmental Estrogens on Neurons
    Scott M Belcher; Fiscal Year: 2010
    ..The ability of ERa, ERp, and the orphan G-protein coupled receptor GPR30 to act as the membrane ER will be directly addressed. ..
  27. GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    William Weiss; Fiscal Year: 2004
    ..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
  28. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  29. Gangliosides and the Biology of Human Neuroblastoma
    Stephan Ladisch; Fiscal Year: 2008
    ..abstract_text> ..
  30. SUBUNIT ASSEMBLY DOMAINS--TARGETS TO LIMIT NEUROTOXICITY
    Scott Belcher; Fiscal Year: 2002
    ..abstract_text> ..
  31. Pirfenidone in Children with PNs in NF1
    Roger Packer; Fiscal Year: 2006
    ..Abstract Not Provided ..
  32. Cellular Immunotherapy for Neuroblastoma With CTL clones
    Michael Jensen; Fiscal Year: 2002
    ..4.) To assess in this patient population the development of antibody and cellular immune responses against the scFvFc:zeta and HyTK chimeric proteins. ..
  33. The Roles of Osteonectin and Osteoactivin in Gliomas
    Jeremy Rich; Fiscal Year: 2007
    ..2) Validate osteonectin and osteoactivin as potential therapeutic targets in glioma invasion. It is hoped that these studies will provide the basis of novel therapeutic interventions for patients with malignant gliomas. ..
  34. Actions of Estrogen & Environmental Estrogens on Neurons
    Scott Belcher; Fiscal Year: 2004
    ..From these results a neuronal "E2-signature cDNA array" will be developed and used in Aim 3 to determine how environmental estrogens influence E2-responsive gene expression in these developing neurons. ..
  35. PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCER
    Charles Sklar; Fiscal Year: 2002
    ..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
  36. INVERSE METASTATIC MODALITIES BY HEPARANASES
    Dario Marchetti; Fiscal Year: 2005
    ..They will provide a framework for the development of polysaccharide-based anti-cancer molecules as important prognostic tools and diagnostic screens for metastatic detection, diagnosis and treatment. ..
  37. Regulation of Ras through the Ras GRF exchange factor
    Raymond Mattingly; Fiscal Year: 2005
    ..The results are likely to be of fundamental importance to our comprehension of the role of the Ras/MAP kinase system in learning and memory. ..
  38. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  39. CHILDRENS NATIONAL MEDICAL CENTER
    Roger Packer; Fiscal Year: 2003
    ....
  40. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  41. Myc Signaling in Medulloblastomas
    Charles Eberhart; Fiscal Year: 2006
    ..Finally, in Specific Aim 4 we propose developing a novel medulloblastoma transgenic model by overexpressing c-Myc in the cerebellum of transgenic mice. ..
  42. Glioma Immunotherapy Usingengineered T-Cells
    Michael Jensen; Fiscal Year: 2006
    ..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
  43. Imaging Kinase Activity In Vivo
    William Weiss; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. Complex ganglioside function in neuroblastoma
    Stephan Ladisch; Fiscal Year: 2008
    ..role of complex "b" pathway gangliosides in the formation and progression of human NB specifically, and neuroectodermal tumors in general, and provide a basis for the development of novel therapeutic approaches for this class of ..