Genomes and Genes
Summary: Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.
Publications223 found, 100 shown here
- Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?Torsten Ehrig
Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
Ann Diagn Pathol 11:153-9. 2007..0 years). Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES. These may have a hitherto unrecognized variant genetic abnormality...
- Anti-GD3 chimeric sFv-CD28/T-cell receptor zeta designer T cells for treatment of metastatic melanoma and other neuroectodermal tumorsAgnes S Y Lo
Division of Surgical Research, Department of Surgery, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
Clin Cancer Res 16:2769-80. 2010....
- Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumorsB Fazi
Department of Biology, University of Rome Tor Vergata, Rome 133, Italy
Oncogene 28:3814-24. 2009..These data demonstrate a molecular mechanism by which RTN-1C controls apoptosis and indicate this protein to be a novel potential target for cancer therapy...
- Primitive neuroectodermal tumors of adrenal glandYushi Zhang
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
Jpn J Clin Oncol 40:800-4. 2010To analyze the clinical and pathological characteristics of adrenal primitive neuroectodermal tumors for a better understanding of the disease.
- Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastomaMei Hua Li
Arthur and Sonia Labatt Brain Tumor Research Centre, Cancer Research Program, Division of Hematology and Oncology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada
Neurosurg Focus 19:E3. 2005The supratentorial primitive neuroectodermal tumors (PNETs) are a group of highly malignant lesions primarily affecting young children...
- Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal originGuido Kohla
Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
Neurochem Res 27:583-92. 2002....
- Detection of N-glycolyl GM3 ganglioside in neuroectodermal tumors by immunohistochemistry: an attractive vaccine target for aggressive pediatric cancerAlejandra M Scursoni
Departament of Pathology, Pediatric Hospital Prof Dr Juan P Garrahan, and Laboratory of Molecular Oncology, Quilmes National University, C1245AAM Buenos Aires, Argentina
Clin Dev Immunol 2011:245181. 2011..Our aim was to evaluate the presence of NeuGc-GM3 in pediatric neuroectodermal tumors by immunohistochemistry...
- Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasmSaeid Movahedi-Lankarani
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, U S A
Am J Surg Pathol 26:1040-7. 2002Primitive neuroectodermal tumors (PNETs) have rarely been described in solid organs. We report a series of seven PNETs of the pancreas...
- EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocationsM Giovannini
Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
J Clin Invest 94:489-96. 1994..the frequency of EWS fusion transcripts in a series of primary Ewing's sarcomas and peripheral primitive neuroectodermal tumors and cells lines. Type 1 and 2 EWS-Fli1 fusions were demonstrated in 8 cell lines and 14 patient samples...
- High-dose chemotherapy with autologous stem-cell rescue in the treatment of patients with recurrent non-cerebellar primitive neuroectodermal tumorsAlberto Broniscer
Children s Cancer Group New York University Medical Center, New York, NY, USA
Pediatr Blood Cancer 42:261-7. 2004Recurrent non-cerebellar primitive neuroectodermal tumors (PNETs) carry a dismal prognosis when treated with conventional chemotherapy alone...
- Ewing sarcoma and sinonasal neuroectodermal tumors as second malignant tumors after retinoblastoma and other neoplasmsJ U Cope
Genetic Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892 7362, USA
Med Pediatr Oncol 36:290-4. 2001..To update and advance this information, case reports were sought by an extensive review of the literature...
- Does sophisticated diagnostic workup on neuroectodermal tumors have an impact on the treatment of esthesioneuroblastoma?I Haas
Klinik für HNO Heilkunde, Kopf und Halschirurgie, Universitatsklinikum Dusseldorf, Germany
Onkologie 26:261-7. 2003..We have investigated whether improvements in diagnosis of sinonasal neuroectodermal tumors, including esthesioneuroblastomas (ENB), sinonasal neuroendocrine carcinomas (SNEC) and sinonasal ..
- Gastrointestinal neuroendocrine/neuroectodermal tumorsC M Fenoglio-Preiser
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, OH 45267-0529, USA
Am J Clin Pathol 115:S79-93. 2001..Tumor arrays within a given site, as in the stomach, are compared with one another to highlight their histologic features and differing biologies. General treatment guidelines are also provided...
- Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumorsHyunsuk Shim
Department of Radiology, Emory University, Atlanta, GA 30322, USA
Semin Cancer Biol 19:123-34. 2009..As an attractive therapeutic target of CXCR4/CXCL12 axis for cancer chemotherapy, development history and application of CXCR4 antagonists are described...
- Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem cell rescueThomas Lehrnbecher
Department of Pediatric Hematology, Johann Wolfgang University of Frankfurt, Germany
Pediatr Infect Dis J 25:465-6. 2006..No other site of invasive aspergillosis was evident. The patient was successfully treated with early surgery and combination antifungal therapy...
- [Tumors of the central nervous system in children in the Republic of Belarus: morbidity and survival on a population level]S V Petrovich
Vopr Onkol 48:306-10. 2002
- Molecular analysis of pediatric brain tumorsJaclyn A Biegel
Division of Human Genetics, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
Curr Oncol Rep 6:445-52. 2004..Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment...
- Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastomaThomas E Merchant
Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Int J Radiat Oncol Biol Phys 65:210-21. 2006..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
- Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91Beate Timmermann
Department of Radiooncology, and Institute of Medical Information Processing, University of Tubingen, Tubingen, Germany
J Clin Oncol 20:842-9. 2002To evaluate the outcome of children with supratentorial primitive neuroectodermal tumors after surgery, irradiation, and chemotherapy and to identify factors predictive for survival.
- MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltrationSatoshi O Suzuki
Division of Neuropathology, Columbia University College of P and S, New York, New York, USA
J Neuropathol Exp Neurol 61:403-12. 2002..MAP-2e was not expressed in non-CNS tumors or neuroblastomas. Thus. neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia...
- Recent advances in paediatric neuro-oncologyFrank Saran
Department of Radiotherapy, Royal Marsden Hospital NHS Trust, Sutton, Surrey, UK
Curr Opin Neurol 15:671-7. 2002..Over the last 12-18 months a significant number of institutional and national studies have been reported which are likely to impact on the design of future clinical trials...
- A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group studyMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 110:2535-41. 2007....
- Generating prior probabilities for classifiers of brain tumours using belief networksGreg M Reynolds
Department of Electrical, Electronic and Computer Engineering, University of Birmingham, Birmingham, UK
BMC Med Inform Decis Mak 7:27. 2007..g. combining imaging information with spectroscopy. In this work a method of generating probabilities of tumour class from anatomical location is presented...
- High-dose chemotherapy in childhood brain tumorsJ E A Wolff
Abteilung Pädiatrische Hämatologie und Onkologie, Krankenhaus Barmherzige Brüder, Klinik St Hedwig, Regensburg, Germany
Onkologie 27:239-45. 2004..The data suggest benefit in recurrent primitive neuroectodermal tumors (PNET), in newly diagnosed young children with PNET and possibly in young children with newly diagnosed ..
- [Supratentorial primitive neuroectodermal tumor: a single center experience and comparison with the literature]I Schmid
Kinderklinik und Kinderpoliklinik im Dr von Haunerschen Kinderspital, Ludwig Maximilians Universitat Munchen
Klin Padiatr 217:153-7. 2005Supratentorial primitive neuroectodermal tumors (stPNETs) are malignant tumors. We saw within three years six children with stPNETs. In four of the six children radical resection could be achieved...
- Fetal growth and the risk of childhood CNS tumors and lymphomas in Western AustraliaElizabeth Milne
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
Int J Cancer 123:436-43. 2008..The associations we observed are consistent with causal pathways involving fetal growth factors...
- Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumorArnold C Paulino
Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA
Int J Radiat Oncol Biol Phys 58:1171-6. 2004..Supratentorial primitive neuroectodermal tumor (PNET) accounts for 2-3% of all pediatric brain tumors. We retrospectively reviewed all supratentorial PNET cases treated with radiotherapy (RT) at our institutions...
- A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomasC De Bustos
Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
J Med Genet 42:31-7. 2005..The molecular mechanisms responsible for the PDGFRalpha expression in tumours are not known, but in the absence of amplification, changes in transcriptional regulation might be an important factor in this process...
- Dysembryoplastic neuroectodermal tumor: an ultrastructural study of six casesW Biernat
Department of Tumor Pathology, , Poland
Ultrastruct Pathol 25:455-67. 2001..The authors conclude that OLC exhibit clear-cut characteristics of neuronal cells and not true oligodendocytes...
- Malignant ectomesenchymoma of the cerebrum. Case report and discussion of therapeutic optionsElisabeth Weiss
Department of Radiotherapy and Radiooncology, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
Eur J Pediatr 164:345-9. 2005..Therapy was tolerated well without any severe side effects. Six years from diagnosis, the patient is alive without a tumour relapse...
- Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopyTina Young Poussaint
Department of Radiology, Harvard Medical School, Boston, MA, USA
Neuroimaging Clin N Am 16:169-92, ix. 2006..These techniques are complementary to conventional MR imaging in providing tumor physiologic information useful for diagnosis and therapy...
- [Cytopathology of malignant blastematous tumors]Philippe Vielh
Institut Gustave Roussy Département de Pathologie, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
Ann Pathol 24:568-73. 2004....
- Boost Gamma Knife surgery during multimodality management of adult medulloblastomaAnand V Germanwala
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 108:204-9. 2008..The aim of this paper was to determine prognostic factors for adult medulloblastoma treated with boost Gamma Knife surgery (GKS) following resection and craniospinal irradiation...
- [Successful treatment with caspofungin of an invasive candidosis resistant to liposomal amphotericin B in a neutropenic patient]A Rome
Arch Pediatr 13:1556-7. 2006
- Preliminary results of dose intensive pre-irradiation chemotherapy in patients older than 10 years of age with high risk medulloblastoma and supratentorial primitive neuroectodermal tumorsKavita Dhodapkar
New York University Medical Center, New York, NY, USA
Med Pediatr Oncol 38:47-8. 2002
- Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studiesW Papierz
Department of Pathological Anatomy, Medical Academy Lodz, Poland
Ultrastruct Pathol 19:147-66. 1995..of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs)...
- Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndromeMichel De Vos
Molecular Medicine Unit, University of Leeds, Leeds LS9 7TF, United Kingdom
Am J Hum Genet 74:954-64. 2004..For technical reasons, their involvement in childhood cancer, particularly in primitive neuroectodermal tumor, may have been underestimated...
- Imatinib mesylate (STI571) interference with growth of neuroectodermal tumour cell lines does not critically involve c-Kit inhibitionGeertuy Te Kronnie
Department of Pediatrics, University of Padova, 35128 Padova, Italy
Int J Mol Med 14:373-82. 2004A therapeutic role of STI571 (imatinib mesylate) has been anticipated in patients with c-Kit positive neuroectodermal tumors. We examined the efficacy of STI571 to inhibit expansion of c-Kit positive neuroectodermal tumor cell lines in ..
- Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implicationsFabio Pastorino
Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148, Genoa, Italy
Ann N Y Acad Sci 1028:90-103. 2004b>Neuroectodermal tumors are highly malignant and increasingly common tumors. Because the cure rate of these neoplasias by conventional treatment is very low, new therapeutic approaches are needed...
- Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57M Corazzari
1INMI IRCCS Lazzaro Spallanzani, Rome 00149, Italy
Br J Cancer 96:1062-71. 2007..Therefore, ER-resident proteins such as ERdj5 and ERp57 may represent novel chemotherapeutic targets...
- Drug delivery systems: application of liposomal anti-tumor agents to neuroectodermal cancer treatmentDaniela Di Paolo
Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
Tumori 94:246-53. 2008..The most multifunctional targeted liposomes are herein described, with primary attention on testing their efficacy in clinically relevant animal models for the treatment of neuroblastoma and melanoma...
- Comparative study using rabbit-derived polyclonal, mouse-derived monoclonal, and rabbit-derived monoclonal antibodies for KIT immunostaining in GIST and other tumorsMasako Saito
Department of Tumor Pathology, Graduate School of Medicine, Gunma University, Gunma, Japan
Pathol Int 57:200-4. 2007..At present, pAb A4502 or RabMA Y145 seems to be suitable for KIT immunostaining in formalin-fixed paraffin-embedded tumor specimens, especially in the differential diagnosis of GIST from other mesenchymal tumors...
- Posttransplant adoptive immunotherapy with interleukin-2 in children suffering from neuroectodermal tumors with poor prognosisK Kałwak
Department of Pediatric Hematology and Oncology, Medical University of Wrocław, 44 Bujwida Street, 50 345 Wrocław, Poland
Transplant Proc 34:665-7. 2002
- Guidelines for radioiodinated MIBG scintigraphy in childrenPierre Olivier
CHU Nancy, France
Eur J Nucl Med Mol Imaging 30:B45-50. 2003..The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations...
- Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasmsYulin Liu
Department of Pathalogy and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Adv Anat Pathol 10:101-6. 2003..This report details the diagnostic value of MAP-2 on tumors with neuroendocrine differentiation and neoplasms derived from the neural crest...
- Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous systemA Taraszewska
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw
Folia Histochem Cytobiol 40:207-8. 2002....
- Pigmented intraosseous odontogenic carcinoma of the maxilla: a pediatric case report and differential diagnosisR Ijiri
Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan
Hum Pathol 32:880-4. 2001..We consider that the present tumor suggests a close association of ectoderm, mesenchyma, and neuroectoderm in embryogenesis of the tooth, and can raise a diagnostic confusion with melanotic neuroectodermal tumor...
- A rare primitive neuroectodermal tumour presenting unusually in a postmenopausal womanJ Doshi
Department of Obstetrics and Gynaecology, Hemel Hempstead General Hospital, UK
J Obstet Gynaecol 23:684-5. 2003
- Cerebral primitive neuroectodermal tumour in a heiferM N Lucas
Unité d Anatomie Pathologique, Ecole Nationale Veterinaire de Nantes, Atlanpole, La Chantrerie, BP 40706 F 44307, Nantes Cedex 03, France
J Comp Pathol 128:195-8. 2003..Immunolabelling was positive for vimentin and neuron-specific enolase, in agreement with previous reports of PNETs in human beings and animals. This appears to be the first report of cerebral PNET in cattle...
- Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytesSabine Spiegl-Kreinecker
Department of Neurosurgery, Landesnervenklinik Wagner Jauregg Hospital, Linz, Austria
J Neurooncol 57:27-36. 2002..and multidrug-resistance protein 1 (MRP1) in cell lines (N = 24) and primary cell cultures (N = 36) from neuroectodermal tumors, as well as in brain tumor extracts (N = 18) and normal human astrocytes (N = 1)...
- Perioperative headaches in an adolescent: a most complex situationRafael Campanini
Department of Anesthesiology Pain Management, The Children s Hospital and University of Colorado Health Sciences Center, 1056 East 19th Avenue, B090, Denver, CO 80218, USA
J Adolesc Health 34:535-9. 2004
- Serum and CSF immunoglobulins G, A and M in 37 intracranial tumorsK Dawani
Department of Pathology, Dow Medical College, Karachi
J Pak Med Assoc 52:549-53. 2002..To estimate different proteins and immunoglobulins as humoral immune response in patients with intracranial tumours...
- Rapid increase in volume of multiple tumor cysts after intracranial pressure reductionYoshio Taguchi
Division of Neurosurgery, St Marianna University Yokohama City Seibu Hospital, Yokohama, Japan
Pediatr Neurosurg 42:132-3. 2006
- 40 year-old male with history of brain tumor 10 years agoAtik Baborie
Department of Neuropathology, Newcastle General Hospital, Newcastle upon Tyne, UK
Brain Pathol 17:337-9. 2007
- Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin?Martina M Uttenreuther-Fischer
Charite, Hochschulmedizin Berlin, Campus Virchow Klinikum, Children s Hospital, Dept General Pediatrics, Germany
J Immunol 176:7775-86. 2006..18. Rabbits vaccinated with GK8 or GK2 (weaker) produced Ab3 against the original target Ag GD2. GK8 may be useful as a tumor vaccine for GD2-positive [corrected] tumors...
- Targeted expression of MYCN causes neuroblastoma in transgenic miceW A Weiss
G W Hooper Foundation, and Department of Neurology, University of California, San Francisco 94143 0552, USA
EMBO J 16:2985-95. 1997....
- Gangliosides inhibit the development from monocytes to dendritic cellsM Wolfl
Department of Paediatric Oncology and Hematology, Children s Hospital, University of Cologne, Germany
Clin Exp Immunol 130:441-8. 2002..Suppression was induced by GM2, but not by the other gangliosides. These data suggest that certain gangliosides impair DC precursors, implying a possible mechanism for tumour escape...
- Fine-needle aspiration of adult small-round-cell tumors studied with flow cytometryMarino E Leon
Department of Pathology and Laboratory Medicine, Drexel University, College of Medicine, Philadelphia, Pennsylvania 15212, USA
Diagn Cytopathol 31:147-54. 2004..ES/PNET in FNA and BMA can be efficiently and rapidly diagnosed by combining cytologic examination with FCI using a panel including CD45, CD16/56, and CD99...
- Automated nuclear image morphometry on fine needle aspiration smears of malignant round cell tumorsU Brahmi
Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Anal Quant Cytol Histol 23:287-90. 2001..It was possible to differentiate WT and NHL with ICM. Nuclear ICM was not significantly different in the NB, PNET and ES groups, and probably ICM would not be very helpful to differentiate these groups of MRCT...
- Nerve growth factor regulates neuroectodermal tumor cell responses to mitogenic growth factorsRaquel Castellon
Department of Ophthalmology, University of California Irvine, USA
J Neurosci Res 72:239-49. 2003..These results suggest that NGF could exert similar actions on cellular responses to growth factors in vivo...
- Marrying pediatric oncology to biological research: cell communication in neuroectodermal tumors: introduction to the workshopLuisa M E Massimo
Pediatric Hematology and Oncology Unit G Gaslini, Scientific Children s Hospital, 16147 Genova, Italy
Ann N Y Acad Sci 1028:56-8. 2004
- Characteristics and outcome of children with primary soft tissue sarcomas of extremitiesJoanna Zawitkowska-KlaczyÅ„ska
Department of Peadiatric Haematology and Oncology, Medical University, Chodzki 2 St, Lublin, Poland
Med Wieku Rozwoj 8:169-74. 2004..To determine the characteristics and outcome or patients with primary soft tissue sarcomas of extremities in children...
- Morphologic characterization of spontaneous nervous system tumors in mice and ratsG J Krinke
Toxicology Department, Novartis Crop Protection AG, Stein, Switzerland
Toxicol Pathol 28:178-92. 2000..Primitive neuroectodermal tumors of rats, such as pineal tumors or medulloblastomas, appear to have features similar to those found in man...
- Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerationsK Devaney
Department of Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC
Hum Pathol 24:1211-25. 1993..rather appeared in some small cell osteosarcomas, Ewing's sarcomas, atypical Ewing's sarcomas, primitive neuroectodermal tumors, mesenchymal chondrosarcomas, lymphomas, and Askin tumors...
- Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumorsR T Woodburn
Department of Radiation Oncology, Indiana University Medical Center, Indianapolis 46202, USA
J Neurooncol 52:57-62. 2001..Intense p53 immunostaining may predict for a poor prognosis in central nervous system primitive neuroectodermal tumor of childhood...
- Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitrosourea-based chemotherapyM D Prados
Department of Neurosurgery, University of California, San Francisco, USA
Pediatr Neurosurg 25:174-81. 1996..PFS) of children and adults with newly diagnosed medulloblastoma, pineoblastoma, and other primitive neuroectodermal tumors (PNET) with a combined modality regimen of radiation therapy and adjuvant nitrosourea-based chemotherapy.
- Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study groupS Stegmaier
Olgahospital, Stuttgart, Germany
Klin Padiatr 216:315-22. 2004..of about 80-90 % of Ewing's sarcoma family of tumors [bone and soft tissue Ewing's sarcoma and peripheral neuroectodermal tumors (PNET)]. They generate ews/fli1 rearrangements showing great diversity in breakpoint exon combination...
- Foreign body reaction to hemostatic materials mimicking recurrent brain tumor. Report of three casesK F Kothbauer
Department of Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
J Neurosurg 95:503-6. 2001..All patients were boys (3, 3, and 6 years of age, respectively) and all harbored primitive neuroectodermal tumors. Two tumors were located in the posterior fossa and one was located in the right parietal lobe...
- Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective studyMartin Benesch
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria
Anticancer Drugs 20:794-9. 2009..refractory medulloblastoma (n = 12), mixed germ cell tumor (n = 2), central nervous system primitive neuroectodermal tumors of the pons (n = 1), anaplastic ependymoma (n = 1), anaplastic oligodendroglioma (n = 1), atypical ..
- Expression of MYCN in pediatric synovial sarcomaGino R Somers
Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
Mod Pathol 20:734-41. 2007..sarcomas and 29 other sarcomas (four malignant peripheral nerve sheath tumors, 15 Ewing sarcoma/primitive neuroectodermal tumors, 10 undifferentiated sarcomas) were examined for MYCN expression and gene amplification...
- Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic miceK M Fung
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia
Lab Invest 70:114-24. 1994..Two of the four lines developed primitive neuroectodermal tumors (PNETs) in the brain stem or pineal gland...
- Recent advances in pediatric renal neoplasiaPedram Argani
The Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 10:243-60. 2003..Primary renal synovial sarcomas and renal primitive neuroectodermal tumors have become accepted entities, and likely comprise a subset of what had previously been termed "adult ..
- Renal tumors in children aged 10-16 Years: a report from the United Kingdom Children's Cancer and Leukaemia GroupSergey D Popov
Department Paediatric Oncology, The Institute of Cancer Research, London, UK
Pediatr Dev Pathol 14:189-93. 2011..6%), 10 (14.9%) renal cell carcinomas, 3 (4.5%) renal medullary carcinomas, 2 (3%) primitive neuroectodermal tumors, 1 clear cell sarcoma of kidney, and 1 desmoplastic small round cell tumor...
- Molecular genetic study of a metastatic oligodendrogliomaM T Giordana
Department of Neuroscience, University of Turin, Turin, Italy
J Neurooncol 66:265-71. 2004Extracranial spread of neuroectodermal tumors is an unusual event, most frequently expected from glioblastomas and medulloblastomas. Single cases of metastatic oligodendrogliomas have been described, but no genetic data are reported...
- A general aspect on soft-tissue sarcoma and c-kit expression in primitive neuroectodermal tumor and Ewing's sarcoma. Is there any role in disease process?Ismail O Kara
Department of Medical Oncology, Faculty of Medicine, Cukurova University, 01330, Adana, Turkey
Saudi Med J 26:1190-6. 2005Within soft-tissue sarcoma, primitive neuroectodermal tumors have been shown to cover a wide spectrum of small round cell sarcomas, including Ewing's sarcomas (ES) and primitive neuroectodermal tumors (PNET)...
- Central nervous system tumors in patients under three years of age: treatment results of a single instituteAli Varan
Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey
Pediatr Neurosurg 42:89-94. 2006..medulloblastoma, 4 ependymoblastoma, 5 with atypical teratoid rhabdoid and 2 with supratentorial primitive neuroectodermal tumors), 21 (24.4%) with ependymoma, 14 (16.3%) with optic glioma, 10 (11.6%) with astrocytoma, 3 (3...
- Significant differences in the matrix metalloproteinase expression profiles of spontaneous medulloblastomas/primitive neuroectodermal tumors as compared with their xenografted, established tumor cell line derived counterpartsB Bodey
Department of Pathology, University of Southern California, Los Angeles, CA, USA
In Vivo 14:675-82. 2000..cells derived from an established cell-line [DAOY#3]) childhood medulloblastomas (MEDs)/primitive neuroectodermal tumors (PNETs) employing an indirect alkaline phosphatase conjugated immunocytochemical technique...
- The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptideE R Lawlor
Department of Pathology, British Columbia s Children s Hospital, Vancouver, Canada
Cancer Res 58:2469-76. 1998The Ewing tumor family of peripheral primitive neuroectodermal tumors (pPNETs) are characterized by chromosomal translocations leading to EWS-ETS gene fusions...
- Identification of novel biomarkers in pediatric primitive neuroectodermal tumors and ependymomas by proteome-wide analysisJudith M de Bont
Department of Pediatric Oncology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
J Neuropathol Exp Neurol 66:505-16. 2007The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas...
- Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapyMaura Massimino
Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
Int J Radiat Oncol Biol Phys 64:1031-7. 2006Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial.
- Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 casesAmir Behdad
Department of Pathology, Cedar Sinai Medical Center, Los Angeles, Calif, USA
Brain Pathol 20:441-50. 2010Central nervous system (CNS) primitive neuroectodermal tumors (PNETs) include supratentorial, brain stem, and spinal cord tumors with medulloblastoma-like histopathology...
- Surgical treatment and prognosis of primitive neuroectodermal tumors of the thoraxAdalet Demir
Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul University, Istanbul, Turkey
J Thorac Oncol 4:185-92. 2009Primitive neuroectodermal tumors (PNETs) are rare, rapidly progressive, small- round cell tumors with a poor prognosis despite multimodal therapy, including surgery and chemoradiotherapy...
- A fourth ventricle atypical teratoid/rhabdoid tumor in an infantChikanori Inenaga
Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
Brain Tumor Pathol 20:47-52. 2003..nervous system tumor entity, occurs in children and is more malignant than medulloblastoma/primitive neuroectodermal tumors (PNET). We report here a case of AT/RT in a male infant who was 9 months old at the time of diagnosis...
- Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End ResultsDawn Elizabeth McNeil
Division of Cancer Epidemiology and Genetics, NCI NIH EPS, Rockville, Maryland 20892 7236, USA
Med Pediatr Oncol 39:190-4. 2002It has been suggested that cerebellar medulloblastoma (M) and primitive neuroectodermal tumors (PNET) arising elsewhere in the nervous system, represent a single entity (M/PNET), although this concept is controversial...
- Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in childhood medulloblastomas/primitive neuroectodermal tumorsB Bodey
Department of Pathology, University of Southern California, Los Angeles 91335, USA
Anticancer Res 20:1769-80. 2000..The value of these genes and proteins in the early diagnosis and possible treatment of various human neoplasms, including childhood brain tumors, should be assessed in further immunocytochemical and molecular biological experiments...
- Telomerase activity and alterations in telomere length in human brain tumorsS Hiraga
Department of Neurosurgery, Osaka University Medical School, Suita, Japan
Cancer Res 58:2117-25. 1998..High telomerase activity was exhibited in all primitive neuroectodermal tumors, anaplastic oligoastrocytomas, neuroblastomas, and oligodendrogliomas...
- Impact of high-dose busulfan plus melphalan as consolidation in metastatic Ewing tumors: a study by the Société Française des Cancers de l'EnfantOdile Oberlin
Department of Paediatric Oncology, Institut Gustave Roussy, rue Camille Desmoulins, Villejuif, France
J Clin Oncol 24:3997-4002. 2006To improve the prognosis for patients with metastatic Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) using conventional chemotherapy and consolidation high-dose chemotherapy (HDCT) containing busulfan and melphalan.
- The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcomaErinn Downs-Kelly
Department of Anatomic, Cleveland Clinic, Cleveland, OH 44195, USA
Diagn Mol Pathol 18:138-43. 2009..n = 8), neuroblastoma (n = 1), desmoplastic small round cell tumors (n = 2), Ewing sarcoma/primitive neuroectodermal tumors (EWS/PNET; n = 15), and round cell liposarcoma (n = 1)...
- Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case reportH J Girschick
University of Wurzburg, Children s Hospital, Germany
Pathol Oncol Res 7:67-71. 2001Primitive neuroectodermal tumors (PNET) represent about 25% of primary central nervous system tumors in childhood, but congenital PNETs are rare...
- Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literatureElizabeth D Euscher
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 32:219-28. 2008Uterine tumors with neuroectodermal differentiation, frequently referred to as primitive neuroectodermal tumors (PNETs), are uncommon. The clinicopathologic features of 17 such cases reviewed at the M.D...
- Transverse myelitis after therapy for primitive neuroectodermal tumorsNicole J Ullrich
Department of Neurology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Pediatr Neurol 35:122-5. 2006Traditional therapy for malignant primitive neuroectodermal tumors in children includes surgery, multi-agent chemotherapy, and radiation...
- Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virusCharles G Eberhart
Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
BMC Cancer 5:19. 2005..We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined...
- Ataxia-telangiectasia: atypical presentation and toxicity of cancer treatmentRochelle A Yanofsky
Section of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, University of Manitoba and Health Sciences Centre, Winnipeg, MB, Canada
Can J Neurol Sci 36:462-7. 2009....
- ATM gene mutations are not involved in medulloblastoma in childrenElla Liberzon
Molecular Oncology, Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
Cancer Genet Cytogenet 146:167-9. 2003Primitive neuroectodermal tumors (PNET)-medulloblastomas account for approximately 20% of all brain tumors in children. Ataxia-telangiectasia is an autosomal recessive neurological disorder with predisposition to cancer...
- Familial posterior fossa brain tumors of infancy secondary to germline mutation of the hSNF5 geneM D Taylor
Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
Am J Hum Genet 66:1403-6. 2000..tumors of infancy, including central nervous system (CNS) malignant rhabdoid tumor (a subset of primitive neuroectodermal tumors, or PNET) and choroid plexus carcinoma...
- Midline brain tumors in MSV-SV 40-transgenic mice originate from the pineal organW Gotz
Zentrum Anatomie, Abteilung Histologie, Universitat Gottingen, Federal Republic of Germany
Acta Neuropathol 83:308-14. 1992..and the SV 40 promoter develop inheritable uniform midline brain neoplasms showing features of primitive neuroectodermal tumors. The origin and histogenesis of these tumors were investigated in the present study...
- Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumorsA Pagani
Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
Diagn Mol Pathol 1:165-72. 1992..blotting and in situ hybridization) in primary lesions and cell lines of Ewing's sarcomas, primitive neuroectodermal tumors (PNETs), and neuroblastomas...
- The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domainsT Ohno
Department of Microbiology and Immunology, Jefferson Cancer Institute, Philadelphia, PA 19107 5541
Oncogene 9:3087-97. 1994..22, is involved in a wide variety of human solid tumors including Ewing sarcoma, related primitive neuroectodermal tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors...
- Maternal medication use and the risk of brain tumors in the offspring: the SEARCH international case-control studyAmanda H Cardy
Department of Public Health, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
Int J Cancer 118:1302-8. 2006..Analysis was conducted for all participants combined, by tumor type (astroglial, primitive neuroectodermal tumors and other glioma), and by age at diagnosis (< or =5 years; >5 years)...
- Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncologyT W Smith
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655
Clin Neuropathol 12:335-42. 1993..Primitive neuroectodermal tumors (PNETs) (cerebral PNET, medulloblastoma, neuroblastoma) and most neuroendocrine tumors generally showed ..
- INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumorsHong Wei Wang
Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
Hum Gene Ther 20:1308-18. 2009..an adenoviral INSM1 promoter-driven herpes simplex virus thymidine kinase (HSV-tk) construct in primitive neuroectodermal tumors (PNETs). We constructed an adenoviral INSM1 promoter-driven HSV-tk gene for therapy in PNETs...
- Inhibition of matrix proteases to sensitize medulloblastoma cells to radiationAndrei L Gartel; Fiscal Year: 2013Medulloblastomas, which belong to a group of primitive neuroectodermal tumors, are invasive tumors with predominant neuronal differentiation...
- Pesticide Exposure and Childhood Cancer StudyBeate R Ritz; Fiscal Year: 2012..acute myeloid leukemia, acute lymphoblastic leukemia, non Hodgkin lymphoma, astrocytoma, primitive neuroectodermal tumors, Wilms tumor, soft tissue sarcomas) and population-based controls...
- The role of Id proteins in tumor development and angiogenesis in the brainAnna Lasorella; Fiscal Year: 2013..Given the pervasive and aggressive nature of the "angiogenic switch" in neuroectodermal tumors and its dependency on Id expression, we have focused on this cellular system...
- 'Exvading'Invasive Pediatric Brain TumorsRavi V Bellamkonda; Fiscal Year: 2013DESCRIPTION (provided by applicant): Medulloblastomas are highly invasive primitive neuroectodermal tumors of the cerebellum and the most common childhood malignant brain tumor, constituting 20-40% of pediatric brain tumors...
- Role of gangliosides in tumor progressionStephan Ladisch; Fiscal Year: 2012Tumor progression, and particularly that of some neuroectodermal tumors (e.g., neuroblastoma and melanoma) causes most cancer-related morbidity and mortality...
- Clinical pharmacology of cyclophosphamide in pediatric medulloblastoma patientsMichael B Tagen; Fiscal Year: 2010DESCRIPTION (provided by applicant): Medulloblastoma and primitive neuroectodermal tumors (PNETs) are childhood brain tumors where about 40% of patients die due to early tumor recurrence...
- OPENING OF THE BLOOD-BRAIN BARRIER TO ANTITUMOR AGENTSEdward A Neuwelt; Fiscal Year: 2013..for enhancing chemotherapy dose intensity for intracerebral medulloblastoma as a model of primitive neuroectodermal tumors within brain parenchyma, by using BBBD and by depleting glutathione stores in conjunctions with thiol ..
- Human Neurotropic JC Virus and CNS DiseasesKamel Khalili; Fiscal Year: 2006..By using the early genome of JCV, we have created transgenic animals that develop cerebellar primitive neuroectodermal tumors with extraordinary similarity to human medulloblastoma...
- Academic Public Private Partnership ProgramM O DORISIO; Fiscal Year: 2004..tumors seen in adults, pediatric neuroendocrine tumors thus include neuroblastoma and primitive neuroectodermal tumors (PNET) such as medulloblastoma, supratentorial PNET and the Ewings sarcoma family of tumors...
- MOLECULAR ANALYSIS OF PEDIATRIC CANCERSGiovanni Rovera; Fiscal Year: 1993..Project 3 will identify and characterize NGF induced immediate-early genes in primitive neuroectodermal tumors which are incompetent to trans activity other genes whose expression is required for terminal ..
- CHLORIDE CHANNELS: NOVEL TARGETS FOR CANCER TREATMENTSusan Lyons; Fiscal Year: 2000The prognosis for highly invasive peripheral neuroectodermal tumors (PNETs) is discouraging with the current standard of care treatments...
- PHASE I/II TRIAL, INTRACAVITARY LAK/IL-2 IN BRAIN TUMORSMaxim Koslow; Fiscal Year: 1991The prognosis of patients with malignant neuroectodermal tumors is poor despite radiation and chemotherapy. Alternative approaches to cancer therapy have focused on the use of biological response modifiers (BRMs) as antitumor agents...
- PRIMITIVE NEUROECTODERMAL TUMORS OF CHILDHOODPeter Phillips; Fiscal Year: 2000Medulloblastoma (MB) and related CNS primitive neuroectodermal tumors (PNETs) are the most common pediatric malignant brain tumors and major source of neurological morbidity and mortality in children...
- CELL DEATH AND DIFFERENTIATION IN MEDULLOBLASTOMAJohn Trojanowski; Fiscal Year: 1999Medulloblastomas (MBs) are prototypical primitive neuroectodermal tumors (PNETs) of the cerebellum, and they are among the most common pediatric brain tumors...
- RECESSIVE TUMOR GENES IN NEUROECTODERMAL MALIGNANCIESNICHOLAS DRACOPOLI; Fiscal Year: 1990As is the case with many human cancers, neuroectodermal tumors including melanoma and neuroblastoma are characterized by specific karyotypic abnormalities...
- SONIC HEDGEHOG/PTCH PATHWAY IN PNETCorey Raffel; Fiscal Year: 2000..Primitive neuroectodermal tumors are the most common of these. Using best available therapy, 5 year survival for children with PNET is 60%...
- MOLECULAR PROFILES OF SMALL CELL LUNG CARCINOMA ANTIGENSJohn Harper; Fiscal Year: 1991..capitalizing on monoclonal antibodies that recognize a 100 kDa glycoprotein secreted by SCCL and by other neuroectodermal tumors, and a sulfated, 90 kDa cell surface phospho-glycoprotein strongly associated with SCCL that may lead to a ..
- MOLECULAR PROFILE OF MELANOMA AND NEUROBLASTOMA ANTIGENSHolger Lode; Fiscal Year: 2000..approaches that will reduce the rate of tumor cell dissemination in spontaneous metastasis models of neuroectodermal tumors. Major hypotheses to be tested are that either immunotherapy modalities designed to activate immune ..
- GSK-3Beta and Associated Pathways in PNETCorey Raffel; Fiscal Year: 2004Primitive neuroectodermal tumors (PNET) are the most common malignant brain tumor of childhood. Using best available therapy, five-year survival for children with PNET is 60%...
- Role of L1-CAM in Melanoma Progression and AgiogenesisAnthony Montgomery; Fiscal Year: 2007..L1 (or L1-CAM) is a neural cell adhesion molecule that is overexpressed in neuroectodermal tumors. In malignant melanoma, L1-expression correlates with the development of metastatic disease...
- Mammalian genetic analysis of embryonic neural overgrow*Karen Artzt; Fiscal Year: 2006..It is expected that this set of genes will define a new tumor suppressor that plays-a role in the development of primitive neuroectodermal tumors of children.
- Lapatinib in childhood CNS malignanciesMaryam Fouladi; Fiscal Year: 2006..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
- Regulation- Medulloblastoma Growth by alpha-v integrinsTobey Macdonald; Fiscal Year: 2006..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
- TGF BETA AND BRAIN TUMORSJeremy Rich; Fiscal Year: 2002....
- PEDIATRIC ONCOLOGY GROUP STUDIESThomas McLean; Fiscal Year: 2002....
- Actions of Estrogen & Environmental Estrogens on NeuronsScott M Belcher; Fiscal Year: 2010..The ability of ERa, ERp, and the orphan G-protein coupled receptor GPR30 to act as the membrane ER will be directly addressed. ..
- GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMAWilliam Weiss; Fiscal Year: 2004..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
- Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.Daniel J Brat; Fiscal Year: 2010..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
- Gangliosides and the Biology of Human NeuroblastomaStephan Ladisch; Fiscal Year: 2008..abstract_text> ..
- SUBUNIT ASSEMBLY DOMAINS--TARGETS TO LIMIT NEUROTOXICITYScott Belcher; Fiscal Year: 2002..abstract_text> ..
- Pirfenidone in Children with PNs in NF1Roger Packer; Fiscal Year: 2006..Abstract Not Provided ..
- Cellular Immunotherapy for Neuroblastoma With CTL clonesMichael Jensen; Fiscal Year: 2002..4.) To assess in this patient population the development of antibody and cellular immune responses against the scFvFc:zeta and HyTK chimeric proteins. ..
- The Roles of Osteonectin and Osteoactivin in GliomasJeremy Rich; Fiscal Year: 2007..2) Validate osteonectin and osteoactivin as potential therapeutic targets in glioma invasion. It is hoped that these studies will provide the basis of novel therapeutic interventions for patients with malignant gliomas. ..
- Actions of Estrogen & Environmental Estrogens on NeuronsScott Belcher; Fiscal Year: 2004..From these results a neuronal "E2-signature cDNA array" will be developed and used in Aim 3 to determine how environmental estrogens influence E2-responsive gene expression in these developing neurons. ..
- PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCERCharles Sklar; Fiscal Year: 2002..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
- INVERSE METASTATIC MODALITIES BY HEPARANASESDario Marchetti; Fiscal Year: 2005..They will provide a framework for the development of polysaccharide-based anti-cancer molecules as important prognostic tools and diagnostic screens for metastatic detection, diagnosis and treatment. ..
- Regulation of Ras through the Ras GRF exchange factorRaymond Mattingly; Fiscal Year: 2005..The results are likely to be of fundamental importance to our comprehension of the role of the Ras/MAP kinase system in learning and memory. ..
- Intravascular Thrombosis in GlioblastomaDaniel Brat; Fiscal Year: 2005..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
- CHILDRENS NATIONAL MEDICAL CENTERRoger Packer; Fiscal Year: 2003....
- Comparative DNA Microarray Analysis of Brain TumorsDaniel Brat; Fiscal Year: 2006....
- Myc Signaling in MedulloblastomasCharles Eberhart; Fiscal Year: 2006..Finally, in Specific Aim 4 we propose developing a novel medulloblastoma transgenic model by overexpressing c-Myc in the cerebellum of transgenic mice. ..
- Glioma Immunotherapy Usingengineered T-CellsMichael Jensen; Fiscal Year: 2006..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
- Imaging Kinase Activity In VivoWilliam Weiss; Fiscal Year: 2006..unreadable] [unreadable]..
- Complex ganglioside function in neuroblastomaStephan Ladisch; Fiscal Year: 2008..role of complex "b" pathway gangliosides in the formation and progression of human NB specifically, and neuroectodermal tumors in general, and provide a basis for the development of novel therapeutic approaches for this class of ..