liposarcoma

Summary

Summary: A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)

Articles from Journal RESEARCH

Top Publications

  1. ncbi Giant retroperitoneal liposarcoma
    Katsuki Inoue
    Department of Urology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Int J Urol 12:220-2. 2005
  2. ncbi Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
    Isabelle Ray-Coquard
    Centre Leon Berard, Lyon, France EAM 4128 Santé Individu Société, Universite Claude Bernard Lyon I, Lyon, France
    Lancet Oncol 13:1133-40. 2012
  3. ncbi Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules
    George D Demetri
    Center for Sarcoma and Bone Oncology and Ludwig Center of Dana Farber Harvard Cancer Center, Dana Farber Cancer Institute, D1212 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 27:4188-96. 2009
  4. pmc Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma
    Aimee M Crago
    Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Curr Opin Oncol 23:373-8. 2011
  5. pmc Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma
    Stacy Ugras
    Department of Surgery, Sarcoma Biology Laboratory, Sarcoma Disease Management Program, The Rockefeller University, New York, New York, USA
    Cancer Res 71:5659-69. 2011
  6. ncbi Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells
    Song Chwan Fang
    Department of Food Nutrition, Chung Hwa University of Medical Technology, 89 Wenhwa First Street, Tainan 71703, Taiwan
    J Agric Food Chem 56:8859-68. 2008
  7. pmc Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma
    Mark A Dickson
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 31:2024-8. 2013
  8. pmc MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling
    Pingyu Zhang
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 72:1751-62. 2012
  9. ncbi The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors
    Caroline Louis-Brennetot
    Institut Curie, Genetics and Biology of Cancers, Paris Cedex, France
    Genes Chromosomes Cancer 50:896-907. 2011
  10. ncbi Differential gene expression in liposarcoma, lipoma, and adipose tissue
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Invest 23:105-18. 2005

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Articles from Journal RESEARCH1

Publications300 found, 100 shown here

  1. ncbi Giant retroperitoneal liposarcoma
    Katsuki Inoue
    Department of Urology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Int J Urol 12:220-2. 2005
    ..We report a case with an extremely large dedifferentiated liposarcoma that weighed 18 kg...
  2. ncbi Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
    Isabelle Ray-Coquard
    Centre Leon Berard, Lyon, France EAM 4128 Santé Individu Société, Universite Claude Bernard Lyon I, Lyon, France
    Lancet Oncol 13:1133-40. 2012
    We report a proof-of-mechanism study of RG7112, a small-molecule MDM2 antagonist, in patients with chemotherapy-naive primary or relapsed well-differentiated or dedifferentiated MDM2-amplified liposarcoma who were eligible for resection.
  3. ncbi Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules
    George D Demetri
    Center for Sarcoma and Bone Oncology and Ludwig Center of Dana Farber Harvard Cancer Center, Dana Farber Cancer Institute, D1212 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 27:4188-96. 2009
    ..trabectedin in a phase II, open-label, multicenter, randomized study in adult patients with unresectable/metastatic liposarcoma or leiomyosarcoma after failure of prior conventional chemotherapy including anthracyclines and ifosfamide.
  4. pmc Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma
    Aimee M Crago
    Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Curr Opin Oncol 23:373-8. 2011
    b>Liposarcoma, a rare disease, is classified into five histologic subtypes. These include well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized by chromosome 12q13-15 amplification...
  5. pmc Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma
    Stacy Ugras
    Department of Surgery, Sarcoma Biology Laboratory, Sarcoma Disease Management Program, The Rockefeller University, New York, New York, USA
    Cancer Res 71:5659-69. 2011
    b>Liposarcoma remains the most common mesenchymal cancer, with a mortality rate of 60% among patients with this disease...
  6. ncbi Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells
    Song Chwan Fang
    Department of Food Nutrition, Chung Hwa University of Medical Technology, 89 Wenhwa First Street, Tainan 71703, Taiwan
    J Agric Food Chem 56:8859-68. 2008
    ..8 muM in SW 872 human liposarcoma cells...
  7. pmc Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma
    Mark A Dickson
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 31:2024-8. 2013
    ..In a phase I trial of PD0332991, several patients with WDLS or DDLS experienced prolonged stable disease. We performed an open-label phase II study to determine the safety and efficacy of PD0332991 in patients with advanced WDLS/DDLS...
  8. pmc MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling
    Pingyu Zhang
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 72:1751-62. 2012
    b>Liposarcoma can be an aggressive, debilitating, and fatal malignancy. In this study, we identifed miRNAs associated with the differentiation status of liposarcoma to gain insight into the basis for its progression...
  9. ncbi The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors
    Caroline Louis-Brennetot
    Institut Curie, Genetics and Biology of Cancers, Paris Cedex, France
    Genes Chromosomes Cancer 50:896-907. 2011
    ..present in almost all cases without CDK4 amplification, thereby confirming the pivotal role of this pathway in liposarcoma oncogenesis...
  10. ncbi Differential gene expression in liposarcoma, lipoma, and adipose tissue
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Invest 23:105-18. 2005
    ..In addition, genes expressed uniquely in liposarcoma among these and 18 other tissue sample sets were identified...
  11. pmc Aberrant AKT activation drives well-differentiated liposarcoma
    Alejandro Gutierrez
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, MA 02215, USA
    Proc Natl Acad Sci U S A 108:16386-91. 2011
    Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded functional ..
  12. pmc Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis
    Ryan M Gobble
    Department of Surgery, Sarcoma Disease Management Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 71:2697-705. 2011
    ..to liposarcomagenesis and serve as prognostic candidates, we undertook expression profiling of 140 primary liposarcoma samples, which were randomly split into training set (n = 95) and test set (n = 45)...
  13. ncbi TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
    C A Powers
    Division of Molecular Endocrinology, New York University Medical Center 10016, USA
    Mol Endocrinol 12:4-18. 1998
    ..p65 was identified as TLS (translocated-in-liposarcoma), a recently identified member of the RNP family of nuclear RNA-binding proteins whose members are thought to ..
  14. ncbi HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..CDK4 amplicon was located immediately downstream the 5' end of DDIT3, a gene known for being involved in myxoid liposarcoma translocations. DDIT3 was amplified in 3 cases and overexpressed in 9 cases...
  15. ncbi Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours
    A P Dei Tos
    Department of Pathology, Regional Hospitals, Treviso, Italy
    J Pathol 190:531-6. 2000
    ..These findings not only provide insights into the molecular pathogenesis of lipomatous tumours, but also indicate that the immunohistochemical analysis of mdm2 and cdk4 may help to increase diagnostic accuracy...
  16. ncbi Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
    Christoph R Müller
    Department of Tumour Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Int J Cancer 121:199-205. 2007
    ..We have therefore investigated the molecular response to Nutlin treatment in several liposarcoma cell lines with such markers, as well as a panel of other sarcoma cell lines...
  17. ncbi Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression
    Aurora Costa
    Department of Experimental Oncology and Laboratories, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Cancer Res 66:8918-24. 2006
    ..their association with histology, and to compare their prognostic relevance in a series of 93 patients with liposarcoma. ALT was detected by assaying ALT-associated promyelocytic leukemia nuclear bodies and TA was assayed using the ..
  18. ncbi Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours
    P B Aleixo
    Center For Research and Post graduation Heitor Cirne Lima, Universidade Federal de Ciências da Saúde de Porto Alegre, 90050 170, Porto Alegre, Rio Grande do Sul, Brazil
    J Clin Pathol 62:1127-35. 2009
    ..MDM2 and CDK4 protein overexpression have also been identified in these tumours...
  19. ncbi Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
    ..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway...
  20. ncbi Well-differentiated liposarcoma (atypical lipomatous tumors)
    L Laurino
    Department of Pathology, Regional Hospital, Treviso, Italy
    Semin Diagn Pathol 18:258-62. 2001
    Well-differentiated (WD) liposarcoma accounts for about 40% to 45% of all liposarcomas therefore representing the larger subgroup of adipocytic malignancies...
  21. pmc Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma
    S Tariq Mahmood
    Sarcoma Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 129:1963-9. 2011
    ..Patients with documented unresectable or metastatic STS (liposarcoma, leiomyosarcoma and malignant fibrous histiocytoma [MFH]), measurable disease, and 3 or less prior lines of ..
  22. ncbi New frontiers in the treatment of liposarcoma, a therapeutically resistant malignant cohort
    Aviad Hoffman
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Drug Resist Updat 14:52-66. 2011
    The adipogenic origin-derived liposarcoma (LPS) family is the most common soft tissue sarcoma histological subtype...
  23. pmc Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk
    Kimberly Moore Dalal
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:381-91. 2006
    To determine the prognostic significance of histologic subtype in a large series of patients with primary liposarcoma (LS) and to construct a LS-specific postoperative nomogram for disease-specific survival (DSS).
  24. ncbi Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
    Matthieu Bui Nguyen Binh
    Department of Pathology, Institut Bergonié and Université Victor Segalen, Bordeaux, France
    Am J Surg Pathol 31:1557-66. 2007
    Dedifferentiated liposarcoma (DLPS) is one of the most frequent sarcomas of the retroperitoneum and represents most undifferentiated sarcomas of the internal trunk...
  25. ncbi Targeting sarcoplasmic/endoplasmic reticulum Ca²+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma
    Lu Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
    Mol Cancer Ther 10:461-71. 2011
    Human liposarcoma is the most common soft tissue sarcoma. There is no effective therapy so far except for surgery...
  26. ncbi Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6
    Min Guan
    Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 17:1796-806. 2011
    We previously reported that nelfinavir (NFV) induces G(1) cell-cycle block and apoptosis selectively in liposarcoma cell lines due to increased SREBP-1 (sterol regulatory element binding protein-1) expression in the absence of increased ..
  27. pmc Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability
    Aimee M Crago
    Sarcoma Disease Management Program, Department of Surgery, Bioinformatics Core, Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 18:1334-40. 2012
    Molecular events underlying progression of well-differentiated liposarcoma (WDLS) to dedifferentiated liposarcoma (DDLS) are poorly defined...
  28. pmc The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma
    S Pilotti
    Department of Pathology and Cytopathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Br J Cancer 82:1271-5. 2000
    ..In conclusion, MDM2/CDK4 product-based immunophenotyping appears to represent a valuable method for the categorization of arguable LDSL...
  29. pmc Phase I study of nelfinavir in liposarcoma
    Janet Pan
    Department of Medical Oncology, City of Hope, Duarte, CA 91010, USA
    Cancer Chemother Pharmacol 70:791-9. 2012
    ..HIV protease inhibitors are associated with HIV protease inhibitor-related lipodystrophy syndrome. We hypothesized that liposarcomas would be similarly susceptible to the apoptotic effects of an HIV protease inhibitor, nelfinavir...
  30. ncbi Liposarcoma of the spermatic-cord: description of two clinical cases and review of the literature
    Michele Malizia
    Department of Urology, University of Bologna, Policlinico S Orsola Malpighi General Hospital, Bologna, Italy
    Arch Ital Urol Androl 77:115-7. 2005
    Spermatic cord liposarcoma is a rare tumor; currently only 161 cases are described in literature. Natural history of these tumors is marked by the high local recurrence rate...
  31. ncbi H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis
    A Sakamoto
    Departments of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Clin Pathol 115:235-42. 2001
    ..Dedifferentiated liposarcoma is characterized by the coexistence of well-differentiated (WD) and high-grade anaplastic (HG) components...
  32. ncbi Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations
    Aviad Hoffman
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cancer 119:1868-77. 2013
    Myxoid liposarcoma (MLPS), a disease especially of young adults with potential for local recurrence and metastasis, currently lacks solid prognostic factors and therapeutic targets...
  33. ncbi Aberrant calreticulin expression is involved in the dedifferentiation of dedifferentiated liposarcoma
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Pathol 180:2076-83. 2012
    ..gene expression profiling study identified several unique genes that were highly expressed in dedifferentiated liposarcoma, and the gene encoding calreticulin (CALR), a major Ca(2+)-buffering protein that can inhibit adipocyte ..
  34. ncbi Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice
    E G Achilles
    Department of Surgery, Division of Surgical Research, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1075-81. 2001
    ..SCID) mice were xenotransplanted subcutaneously with tumor tissue (n = 55) or cell suspension of a human liposarcoma cell line (SW-872) or subclones (n = 28), with varying cell proliferation rates...
  35. ncbi Liposarcoma of the spermatic cord
    C Bouropoulos
    Department of Urology, Artas General Hospital, Greece
    Int Urol Nephrol 33:397-8. 2001
    Primary malignant tumors of the spermatic cord are rare. We report a case of paratesticular liposarcoma and discuss the prognosis of this neoplasm and its therapeutic implications.
  36. pmc mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma
    Jessica I Spitzer
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Genes Chromosomes Cancer 50:338-47. 2011
    ..We thus investigated whether the loss of one FUS allele by translocation in liposarcoma may be followed by mutations in either the remaining FUS allele or the paralogous EWSR1...
  37. pmc Liposarcoma in children and young adults: a multi-institutional experience
    Winston W Huh
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 57:1142-6. 2011
    There are limited data regarding the differences in clinical presentation and outcome of liposarcomas between adult and pediatric patients. The role of adjuvant radiotherapy in the treatment of childhood liposarcoma is unclear.
  38. ncbi Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma
    Akio Sakamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arch Pathol Lab Med 126:1071-8. 2002
    ..beta-Catenin is an adhesion molecule that also plays a role in the Wnt signaling pathway. Objective.-To analyze beta-catenin mutation and accumulation in a series of liposarcomas and malignant fibrous histiocytomas...
  39. ncbi Liposarcoma of the spermatic cord masquerading as an incarcerated inguinal hernia
    J Matthew Hassan
    Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    Am Surg 69:163-5. 2003
    We present a rare case of liposarcoma of the spermatic cord. There are only 61 reports in the literature. The presenting complaint is usually a painless bulge in the inguinal or scrotal region...
  40. ncbi Activation of metalloproteinases-2 and -9 by interleukin-1alpha in S100A4-positive liposarcoma cell line: correlation with cell invasiveness
    Laura Pazzaglia
    Department of Muscoloskeletal Oncology, Rizzoli Orthopaedic Institute, 40100, Bologna, Italy
    Anticancer Res 24:967-72. 2004
    ..The S100A4 gene may affect the invasive properties of tumor cells through modulation of metalloproteinases (MMPs) and their inhibitors (TIMPs)...
  41. ncbi Is there a role for incomplete resection in the management of retroperitoneal liposarcomas?
    D Shibata
    Division of Surgical Oncology, University of Maryland Medical Center, Baltimore, USA
    J Am Coll Surg 193:373-9. 2001
    ..Most likely to benefit are those patients presenting with primary tumors, suggesting that surgical resection should be attempted in the majority of patients...
  42. ncbi From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation
    Mark D Murphey
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 133A, Washington, DC 20306, USA
    Radiographics 25:1371-95. 2005
    b>Liposarcoma is the second most common type of soft-tissue sarcoma, accounting for 10%-35% of these lesions...
  43. ncbi Well-differentiated and dedifferentiated liposarcomas
    Jean Michel Coindre
    Department of Pathology and INSERM U916, Institut Bergonie, Bordeaux, France
    Virchows Arch 456:167-79. 2010
    Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving ..
  44. ncbi FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells
    Rene Rodriguez
    Andalusian Stem Cell Bank, Centro de Investigacion Biomedica, Consejería de Salud Universidad de Granada, Granada, Spain
    Stem Cells 29:179-92. 2011
    ..However, sarcoma models based on human MSCs are still missing. We attempted to develop a model of liposarcoma by expressing FUS (FUsed in Sarcoma; also termed TLS, Translocated in LipoSarcoma)-CHOP (C/EBP HOmologous ..
  45. ncbi Adult paratesticular tumours
    B Khoubehi
    Department of Urology, Wexham Park Hospital, London, UK
    BJU Int 90:707-15. 2002
  46. ncbi Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    A Crozat
    Department of Medicine, NYU Medical Center, New York 10016
    Nature 363:640-4. 1993
    ..CHOP gene product revealed a fusion between CHOP and a gene provisionally named TLS (translocated in liposarcoma)...
  47. ncbi Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 155:1-24. 2004
  48. ncbi MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively...
  49. ncbi Paratesticular liposarcoma: a clinicopathologic study
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland USA
    Am J Surg Pathol 27:40-7. 2003
    ..One was a myxoid/round cell liposarcoma with 70% round cell areas. All patients were treated by radical orchiectomy...
  50. pmc Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy
    Hyo Song Kim
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    BMC Cancer 9:205. 2009
    Prognosis and optimal treatment strategies of liposarcoma have not been fully defined. The purpose of this study is to define the distinctive clinical features of liposarcomas by assessing prognostic factors.
  51. ncbi Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe
    Carlynn Willmore-Payne
    ARUP Laboratories, Salt Lake City, Utah, USA
    Arch Pathol Lab Med 132:952-7. 2008
    ..Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and well-differentiated liposarcomas but not lipomas...
  52. ncbi Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years
    Harry L Evans
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 31:1-14. 2007
    ..conventional atypical lipomatous tumor (n=15), cellular atypical lipomatous tumor (n=21), dedifferentiated liposarcoma (n=24), and atypical lipomatous tumor with a pleomorphic liposarcoma-like component (n=1)...
  53. pmc Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis
    Lorenza Venturini
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BMC Cancer 10:254. 2010
    ..Most cancers maintain telomeres by activating telomerase but a significant minority, mainly of mesenchymal origin, utilize an alternative lengthening of telomeres (ALT) mechanism...
  54. pmc Added Value of Molecular Biological Analysis in Diagnosis and Clinical Management of Liposarcoma: A 30-Year Single-Institution Experience
    Ronald S A de Vreeze
    Departments of Surgical Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Ann Surg Oncol 17:686-93. 2010
    Treatment decisions and prognosis assessment for liposarcoma is based on a classification that depends on morphological and genetic features. Revisions by experienced referral pathologists are often advocated.
  55. ncbi Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution
    Marco Fiore
    Department of Surgery, National Cancer Institute, Milan, Italy
    Cancer 109:2522-31. 2007
    The objective of this study was to investigate prognostic factors and clinical outcome of myxoid/round cell and pleomorphic liposarcoma.
  56. ncbi Genomic profiling reveals subsets of dedifferentiated liposarcoma to follow separate molecular pathways
    Ralf J Rieker
    Institute of Pathology, University Hospital, INF 220 221, 69120, Heidelberg, Germany
    Virchows Arch 456:277-85. 2010
    ..These data indicate that dedifferentiated LS follow separate tumourigenic pathways and that genetic analysis is important to unravel these differences...
  57. ncbi [Comparison of intensity-modulated postoperative radiotherapy with conventional postoperative conformal radiotherapy for retroperitoneal sarcoma]
    E Musat
    Departement de Radiotherapie, Centre Regional de Lutte Contre le Cancer, Institut Bergonie, 229, cours de l Argonne, 33076 Bordeaux, France
    Cancer Radiother 8:255-61. 2004
    ....
  58. ncbi Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
    T H Rabbitts
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Genet 4:175-80. 1993
    ..We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can ..
  59. ncbi Surgical management of primary and recurrent retroperitoneal liposarcoma
    S J Neuhaus
    Melanoma Sarcoma Unit, The Royal Marsden Hospital NHS Trust, Fulham Road, London SW3 6JJ, UK
    Br J Surg 92:246-52. 2005
    Surgery plays a dominant role in the initial and subsequent treatment of retroperitoneal liposarcoma (RPLS). This study was a review of outcomes of patients treated at the Royal Marsden Hospital.
  60. ncbi Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience
    Erica C Davis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 31:28-36. 2009
    Our aim was to review our experience with liposarcoma of the head and neck region.
  61. ncbi Liposarcoma of the oral and salivary gland region: a clinicopathologic study of 18 cases with emphasis on specific sites, morphologic subtypes, and clinical outcome
    Julie C Fanburg-Smith
    Department of Soft Tissue, The Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Mod Pathol 15:1020-31. 2002
    b>Liposarcoma is rare in the oral and salivary gland region (OSG), previously described in only case reports and two small series. Clinicopathologic features of a large series of these tumors were studied...
  62. ncbi Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma
    Mark J Kransdorf
    Department of Radiology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224 3899, USA
    Radiology 224:99-104. 2002
    To review the reliability of computed tomographic (CT) and magnetic resonance (MR) imaging features in distinguishing lipoma and well-differentiated liposarcoma.
  63. pmc Incidental finding of renal cell carcinoma in recurrent retroperitoneal liposarcoma
    J M L Williamson
    Department of Hepato pancreato biliary Surgery, Hammersmith Hospital, London, UK
    Ann R Coll Surg Engl 90:W4-5. 2008
    This is the first reported case of concomitant renal cell carcinoma with retroperitoneal liposarcoma (also involving the kidney)...
  64. ncbi Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features
    Andoni P Toms
    Department of Medical Imaging, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Skeletal Radiol 32:286-9. 2003
    We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman...
  65. ncbi [Giant dedifferenciated liposarcoma of the spermatic cord]
    Fernando Fernandez
    Servicio de Urología Clínica Rafael Uribe Uribe, Clínica Urológica Salus, Cali, Colombia
    Arch Esp Urol 62:751-5. 2009
    To describe a patient with dedifferentiated liposarcoma of the spermatic cord and to perform a bibliographic review.
  66. ncbi Spindle cell lipoma of the mediastinum: a differential consideration for liposarcoma
    Jason Oaks
    Tulane University School of Medicine, USA
    J Thorac Imaging 22:355-7. 2007
    ..It shares many imaging characteristics with liposarcoma, including the presence of adipose and soft tissue elements...
  67. ncbi Retroperitoneal liposarcoma presenting a indirect inguinal hernia
    H Noguchi
    Department of Surgery I, Okayama University Medical School, Japan
    Acta Med Okayama 55:51-4. 2001
    ..Histopathological diagnosis showed well-differentiated liposarcoma of the sclerosing type...
  68. ncbi Establishment and characterization of a novel dedifferentiated liposarcoma cell line, NDDLS-1
    Takashi Ariizumi
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan
    Pathol Int 61:461-8. 2011
    We established a dedifferentiated liposarcoma cell line (NDDLS-1) that produces interleukin-6 (IL-6) and granulocyte-colony stimulating factor (G-CSF). The parental tumor showed high leukemoid reactions...
  69. ncbi MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors
    Caroline M M Gits
    Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 135:348-61. 2014
    ..More insight into the biology of liposarcoma tumorigenesis is needed to devise novel therapeutic approaches...
  70. pmc High-dose pre-operative helical tomotherapy (54 Gy) for retroperitoneal liposarcoma
    Paul Sargos
    Department of Radiation Oncology, Institut Bergonie, Bordeaux, France
    Radiat Oncol 7:214. 2012
    ..To evaluate the feasibility of pre-operative radiotherapy (54 Gy) with Helical Tomotherapy (HT) followed by surgery...
  71. ncbi Factors associated with outcome in liposarcomas of the extremities and trunk
    E E Pakos
    Department of Radiation Therapy, University of Ioannina, School of Medicine, Ioannina, Greece
    J BUON 15:518-23. 2010
    ..We aimed to evaluate the outcomes of patients with extremities and superficial trunk liposarcomas in relation to some clinicopathological factors...
  72. ncbi Metastatic shoulder liposarcoma to the right ventricle: CT findings
    Aamer Chughtai
    Department of Radiology, Division of Cardiothoracic Radiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Thorac Imaging 22:195-8. 2007
    Metastatic cardiac liposarcoma is rare...
  73. ncbi Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation
    Andrew L Folpe
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:742-9. 2002
    Leiomyosarcomatous (LMS) differentiation is a rare event in liposarcoma (LPS) and may consist of either well-differentiated liposarcoma (WDL) with an intrinsic smooth muscle component, so-called "lipoleiomyosarcoma," (L-LMS) or ..
  74. ncbi Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma
    Keqiang Zhang
    Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Res 73:1298-307. 2013
    ..we first comparatively examined the amplification and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated high-grade pleomorphic sarcoma (UHGPS)...
  75. ncbi Well-differentiated liposarcoma of esophagus
    Bin Yang
    Department of Radiology, Hangzhou First People s Hospital, Hangzhou 310006, China
    Chin Med J (Engl) 119:438-40. 2006
  76. pmc Liposarcoma of the spermatic cord: a report of two cases
    C J Tan
    Surgical Assessment Unit, Daisy Hill Hospital, Newry, UK
    Ann R Coll Surg Engl 94:e10-2. 2012
    ..Careful clinical and radiological examination will help in appropriate preoperative planning and surgery by an experienced surgical team. We report our experience of two cases of such scrotal swellings...
  77. ncbi Metastatic liposarcoma of the thyroid gland
    A R Azar
    Department of Radiology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Br J Radiol 76:750-2. 2003
    Metastatic liposarcoma of the thyroid gland is exceptionally rare. A case of pleomorphic liposarcoma, which manifested as a soft tissue lump in the neck, is described in a 30-year-old woman...
  78. ncbi Recurrent giant liposarcoma of the spermatic cord
    Paola De Nardi
    Department of Surgery, San Raffaele Scientific Institute, Milan, Italy
    Urology 79:113-4. 2012
    A giant recurrent retroperitoneal liposarcoma of the spermatic cord was removed in a 40-year-old man. The tumor measured 50 cm and weighed 42 Kilograms. Radiotherapy and chemotherapy have little role in this neoplasm...
  79. ncbi Liposarcoma of the spermatic cord: report of 2 cases
    T J R Bestman
    Department of Surgery, AZ St Dimpna, Geel, Belgium
    Acta Chir Belg 107:58-9. 2007
    These case reports describe the rare condition of liposarcoma of the funiculus spermaticus. It is treated by radical surgical resection. The diagnosis is usually made postoperatively...
  80. ncbi First report of liposarcoma of the spermatic cord after radical prostatectomy for prostate cancer
    Tateki Yoshino
    Department of Urology, Mazda Hospital, 2 15 Aosaki minami Fuchu cho Akigun, Hiroshima 735 8585, Japan
    Anticancer Res 29:677-80. 2009
    Primary liposarcoma of the spermatic cord (LSC) is a rare neoplasm; there are fewer than 100 cases reported in the English literature worldwide...
  81. pmc Spontaneous diaphragmatic rupture related to local invasion by retroperitoneal liposarcoma
    M Pehar
    University Hospital Mostar, Mostar, Bosnia and Herzegovina
    Ann R Coll Surg Engl 94:e18-9. 2012
    ..through the rupture site from within the retroperitoneum that was proven subsequently to be a dedifferentiated liposarcoma. Second surgery was performed to completely remove the liposarcoma tissue and repair a coincident old right ..
  82. pmc An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors
    Tingsheng Peng
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lab Invest 91:392-403. 2011
    Therapeutic progress in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) is hampered by lack of relevant experimental models, thereby limiting comprehensive molecularly based investigations...
  83. ncbi Primary cardiac liposarcoma causing cardiac tamponade: report of a case
    Aki Kitamura
    Department of Cardiovascular Surgery, Hyogo Brain and Heart Center at Himeji, 520 Saisho Ko, Himeji 670 0981, Japan
    Surg Today 37:974-6. 2007
    The intracardiac growth and extension of liposarcoma was observed in a 60-year-old woman. The epicardial tumor was identified to originate from the anterior wall of the right ventricle...
  84. pmc A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas
    Igor Matushansky
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Am J Pathol 172:1069-80. 2008
    ..the assignment of a unique time point during adipogenesis that strongly correlates to each of the four major liposarcoma subtypes...
  85. ncbi Giant lipomas: a series of 12 consecutive cases and a giant liposarcoma of the thigh
    Ahmet Terzioglu
    Ankara Training and Research Hospital, Department of Plastic and Reconstructive Surgery, Cebeci, Ankara, Turkey
    Dermatol Surg 30:463-7. 2004
    ..It is therefore of primary importance for the clinician to be familiar with epidemiologic and anatomic attributes of these lesions...
  86. ncbi Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis
    Nava Almog
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 20:947-9. 2006
    ..Both tumor types cultured in vitro contain fully transformed cells, but only cells from the nonangiogenic human liposarcoma secrete relatively high levels of the angiogenesis inhibitors thrombospondin-1 and TIMP-1...
  87. ncbi Liposarcoma of the cervico-nuchal region
    Augusto P Casani
    Otolaryngol Head Neck Surg 133:641. 2005
  88. ncbi Laparoscopic resection of metastatic pelvic liposarcoma
    Hong B Shim
    Department of Urology, Seoul Veterans Hospital, Seoul, Korea
    Int Braz J Urol 32:445-7. 2006
    We report a pelvic liposarcoma originating from the left spermatic cord that recurred following inadequate excision. In our case, the tumor was resected without performing orchiectomy previously...
  89. ncbi Late recurrence of liposarcoma simulating adenoma of the duodenum
    F H Wolfhagen
    Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands
    Neth J Med 54:231-4. 1999
    ..of a patient with asymptomatic anaemia, with mucosal biopsies indicating a villous adenoma, turned out to be a liposarcoma during laparotomy. The patient had had a completely resected retroperitoneal liposarcoma 8 years before...
  90. ncbi Dedifferentiated liposarcoma of the oral cavity with angiosarcomatous dedifferentiation
    Isabela Werneck da Cunha
    Department of Pathology, Centro de Tratamento e Pesquisa, Hospital do Cancer, A C Camargo, R Prof Antônio Prudente 211, Liberdade, 01509 900, Sao Paulo, Brazil
    Virchows Arch 446:456-9. 2005
    We report a unique case of a 42-year-old woman with a dedifferentiated liposarcoma of the soft tissue of the oral cavity with angiosarcomatous dedifferentiation...
  91. ncbi The management of retroperitoneal liposarcoma with synchronous intra-duodenal sarcoma
    A Tsang
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    Eur J Surg Oncol 29:515-8. 2003
    ..Intra-duodenal involvement with sarcoma was found intra-operatively. We discuss the management of this condition in the context of an illustrative case in our recent experience...
  92. ncbi Liposarcoma: outcome based on the Scandinavian Sarcoma Group register
    Katarina Engström
    Department of Oncology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Cancer 113:1649-56. 2008
    The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (..
  93. ncbi Primary pulmonary liposarcoma--a case report
    A Achir
    Department of Thoracic Surgery, Ibn Sina Hospital, Rabat, Morocco
    Thorac Cardiovasc Surg 57:119-20. 2009
    b>Liposarcoma of the lung is an extremely rare disease with less than 10 cases reported to date. A case of a locally advanced, pulmonary mixed liposarcoma in a 49-year-old male is presented here...
  94. ncbi Imaging features of primary pulmonary liposarcoma
    Mourad Said
    Department of Diagnostic Radiology, Universitary Hospital of Monastir, Tunisia
    Australas Radiol 47:313-7. 2003
    Primary liposarcoma of the lung is extremely rare. We report a 28-year-old pregnant woman who complained of dyspnoea during the third trimester...
  95. ncbi Well-differentiated liposarcoma of the tongue
    F D Nunes
    Disciplina de Patologia Bucal, Faculdade de Odontologia, Universidade de Sao Paulo, Av Prof Lineu Prestes, 2227, Butanta, CEP 05508 900, Brazil
    Oral Oncol 38:117-9. 2002
    ..We present a well-differentiated liposarcoma of the tongue, in a 65-year-old man...
  96. ncbi Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy
    Paul Nikolaidis
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur Radiol 15:383-9. 2005
    ..the feasibility of image-guided percutaneous needle biopsy to enable specific subtype classification of liposarcoma in patients with previously diagnosed disease and compare the yield of fine and large needle techniques for ..
  97. ncbi Divergent differentiation in malignant soft tissue neoplasms: the paradigm of liposarcoma and malignant peripheral nerve sheath tumor
    Peter Pytel
    Department of Pathology, University of Chicago Hospitals, Chicago, IL 60637, USA
    Int J Surg Pathol 13:19-28. 2005
    ..Among sarcomas, malignant peripheral nerve sheath tumor (MPNST) and dedifferentiated liposarcoma are two entities in which divergent differentiation is a relatively frequent event...
  98. doi Li-Fraumeni syndrome: a case with 4 separate primary sarcomas and 5 sequential free flaps in the maxillofacial region
    Hakan Agir
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital, Wellington, New Zealand
    J Oral Maxillofac Surg 66:1714-9. 2008
  99. ncbi Lipoma or liposarcoma? A cautionary case report
    A P Jones
    Department of Plastic Surgery, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK
    J Plast Reconstr Aesthet Surg 65:e11-4. 2012
    ..We describe a case in which a lipoma-like liposarcoma was identified following excision of what was expected, on clinical and radiological grounds, to be a lipoma...
  100. ncbi Management of spermatic cord liposarcoma in renal transplant recipients: case report
    T M Manzia
    UOC Trapianti d Organo, Sant Eugenio Hospital, University Tor Vergata, Rome, Italy
    Transplant Proc 42:1355-7. 2010
    Herein, we report the case of a 52-year-old man with a spermatic cord liposarcoma that developed 4 years after renal transplantation. The patient was admitted with a diagnosis of inguinal hernia...
  101. ncbi Renal liposarcoma
    Diogo A L Bader
    West Parana State University, UNIOESTE, Cascavel, Parana, Brazil
    Int Braz J Urol 30:214-5. 2004
    b>Liposarcoma is a malignant mesenchymal tumor frequently located in retroperitoneum, and rarely presenting an isolated lesion in kidney.

Research Grants26

  1. ADIPOCYTE GROWTH AND PATHOGENESIS OF LIPOSARCOMA
    David Ron; Fiscal Year: 2001
    ..It is hypothesized that transformation in liposarcoma proceeds by two parallel pathways: (1) The CHOP component of the oncoprotein directs it to one set of target ..
  2. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..The FUS/TLS locus on human chromosome 16 is originally identified to encode an oncogene implicated in malignant liposarcoma and myeloid leukemia...
  3. Role of FUS in ALS
    Haining Zhu; Fiscal Year: 2013
    ..familial ALS, including two genes encoding RNA processing proteins TDP-43 and fused in sarcoma/translocated in liposarcoma (FUS/TLS). FUS is a ubiquitously expressed multi-domain RNA-binding protein...
  4. Effect of ALS-causing Mutations on Binding of TDP43 and FUS to RNA in iMNs
    HELAINA JESSICA SKOP; Fiscal Year: 2013
    ..Mutations in two RNA binding proteins, TAR DNA binding protein 43 (TDP43) and Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS), cause some forms of familial ALS...
  5. Investigating a Toxic Gain-of-Interaction Between FUS/TLS &Stress Granules
    DARYL ANGELA BOSCO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mutations in the gene encoding Fused in Sarcoma/Translocated in Liposarcoma (FUS/TLS or FUS) were recently linked to amyotrophic lateral sclerosis (ALS). ALS is the most common motor neuron disorder...
  6. SOFT TISSUE SARCOMA PROGRAM PROJECT
    Samuel Singer; Fiscal Year: 2010
    ..In Project 1, a new initiative in liposarcoma biology, we will use an integrated gene expression and NMR biochemical analysis to improve diagnosis and ..
  7. Mechanisms of alternative splicing of pre-mRNA
    James L Manley; Fiscal Year: 2013
    ..Lastly, the function of the Translocated in Liposarcoma (TLS) protein in coupling transcription-splicing will be investigated...
  8. ACQUISITION OF A SOLiD 3 SEQUENCER
    AGNES contact VIALE; Fiscal Year: 2010
    ..Samuel Singer, who is taking an integrative approach to characterize liposarcoma subtypes molecularly and biochemically...
  9. Developing New Strategies for Targeting mTOR and IGF-1R/PI3K/Akt Pathways in Sarc
    Gary K Schwartz; Fiscal Year: 2012
    ..dependent and -independent sarcoma cells;and 3) study the impact of PIK3CA mutations upon myxoid-round cell liposarcoma biology and the susceptibility of these tumors to mTOR targeting...
  10. THYROID/RETINOIC ACID RECEPTOR INTERACTING PROTEINS
    Mukul Mathur; Fiscal Year: 2004
    ..binding protein TLS, that was originally identified as part of a fusion protein associated with human myxoid liposarcoma. The 105 kDa protein is a splicing factor known as PSF (PTB associated splicing factor)...
  11. MECHANISMS GENERATING TEMPORAL EMBRYONIC GENE EXPRESSION
    Geoffrey Childs; Fiscal Year: 1999
    ..EWS and TLS, of unknown function except they are involved in chromosomal translocations in Ewings Sarcoma and Liposarcoma respectively...
  12. Mechanisms of mutagenisis in 'hot spots' causing cancer
    Barbara Wright; Fiscal Year: 2002
    ..instability in colon cancer, and T-G repeats and an ATGGTC hexamer are involved in breaks of hybrid genes in liposarcoma and leukemia...
  13. REGULATED TOXIN GENE THERAPY FOR RHABDOMYOSARCOMA
    TIMOTHY CRIPE; Fiscal Year: 2001
    ..This strategy will serve as a paradigm for genetic therapy of other tumors such as Ewing~s sarcoma, liposarcoma, and some forms of leukemia which express analogous chimeric transcription factors.
  14. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..chronic myelogenous leukemia (CML) in blast crisis, and myelodysplastic syndromes, the TLS (translocation liposarcoma) gene is fused to the ERG (ets-related gene) gene through a recurrent t(16;21) translocation...
  15. Transcriptional coactivators and arginine methylation
    Jennifer Butler; Fiscal Year: 2004
    ..Two proteins, an RNA shuttling protein called TLS (translocated in liposarcoma) and PRMT2 (protein arginine methyltransferase 2), were identified as novel CBP-interacting proteins...
  16. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
  17. Molecular Mechanisms of Sensory Neurogenesis
    Eric Huang; Fiscal Year: 2006
    ..abstract_text> ..
  18. Conference on Roles of TGF-Beta in Disease Pathogenesis
    Michael Sporn; Fiscal Year: 2005
    ..The hope is that this meeting will both enhance our insights into pathogenetic mechanisms of action of TGF-Beta in disease and provide novel therapeutic approaches for clinical treatment of disease. ..
  19. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  20. Chemoprevention of Estrogen Receptor Negative Breast Cancer
    Michael Sporn; Fiscal Year: 2007
    ..These studies on apoptosis will be supplemented by measuring effects of chemopreventive agents on Myc gene expression. [unreadable] [unreadable] [unreadable]..
  21. Botannical Extract Library Screeninig with Human ADAS Cells
    Jeffrey Gimble; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERS
    Jeffrey Gimble; Fiscal Year: 2002
    ..This has commercial application to orthopedic and periodontal surgical treatments of joint replacement, fracture repair, and bone resorption secondary to tooth decay...
  23. Spinal Fusion Using Adipose Derived Adult Stem Cells
    Jeffrey Gimble; Fiscal Year: 2005
    ..The availability of "off the shelf ADAS cells for clinical orthopedic procedures will have a significant commercial and therapeutic impact. ..
  24. Fish Oil Modulation of Tumor Inflammation
    NOCIF ESPAT; Fiscal Year: 2006
    ....
  25. CIRCADIAN MECHANISMS REGULATING OSTEOGENESIS
    Jeffrey Gimble; Fiscal Year: 2005
    ..Findings from this innovative proposal have clinical implications regarding the optimal timing for daily medication regimens in bone diseases and for elective orthopedic and orthodontic procedures. ..