angiomyolipoma

Summary

Summary: A benign tumor containing vascular, adipose, and muscle elements. It occurs most often in the kidney with smooth muscle elements (angiolipoleiomyoma) in association with tuberous sclerosis. (Dorland, 27th ed)

Top Publications

  1. ncbi Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
    John J Bissler
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Lancet 381:817-24. 2013
  2. ncbi Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: A clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification
    Nalan Nese
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 35:161-76. 2011
  3. ncbi Malignant hepatic angiomyolipoma: report of a case and review of literature
    Thong T Nguyen
    Department of Pathology, Rosewell Park Cancer Institute, Buffalo, NY 14201, USA
    Am J Surg Pathol 32:793-8. 2008
  4. ncbi Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial
    D Mark Davies
    Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Clin Cancer Res 17:4071-81. 2011
  5. ncbi Small (<4 cm) renal mass: differentiation of angiomyolipoma without visible fat from renal cell carcinoma utilizing MR imaging
    Kewalee Sasiwimonphan
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Radiology 263:160-8. 2012
  6. ncbi Renal epithelioid angiomyolipoma: imaging characteristics in nine cases with radiologic-pathologic correlation and review of the literature
    Adam T Froemming
    Department of Radiology, Mayo Clinic, 200 1st St SE, Rochester, MN 55905, USA
    AJR Am J Roentgenol 200:W178-86. 2013
  7. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
  8. ncbi Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma
    C C Pan
    Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    J Pathol 214:387-93. 2008
  9. ncbi Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 225:78-82. 2002
  10. ncbi Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    Nisreen El-Hashemite
    Brigham and Women Hospital, Department of Medicine, Haematology Division, Boston MA 02115, USA
    Lancet 361:1348-9. 2003

Detail Information

Publications291 found, 100 shown here

  1. ncbi Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
    John J Bissler
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Lancet 381:817-24. 2013
    ..We compared the angiomyolipoma response rate on everolimus with placebo in patients with tuberous sclerosis or sporadic ..
  2. ncbi Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: A clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification
    Nalan Nese
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 35:161-76. 2011
    ..of the kidney are defined as potentially malignant mesenchymal lesions that are closely related to classic angiomyolipoma. Although approximately 120 cases are published, mostly as case reports with variably used diagnostic criteria,..
  3. ncbi Malignant hepatic angiomyolipoma: report of a case and review of literature
    Thong T Nguyen
    Department of Pathology, Rosewell Park Cancer Institute, Buffalo, NY 14201, USA
    Am J Surg Pathol 32:793-8. 2008
    Hepatic angiomyolipoma, a constituent of the group of tumors showing differentiation resembling perivascular epithelioid cells, is primarily appreciated in its benign form...
  4. ncbi Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial
    D Mark Davies
    Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Clin Cancer Res 17:4071-81. 2011
    ..This study investigated the efficacy and safety of the mTORC1 inhibitor sirolimus for treatment of renal angiomyolipomas in patients with these disorders...
  5. ncbi Small (<4 cm) renal mass: differentiation of angiomyolipoma without visible fat from renal cell carcinoma utilizing MR imaging
    Kewalee Sasiwimonphan
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Radiology 263:160-8. 2012
    ..To determine whether a combination of magnetic resonance (MR) parameters can help differentiate small angiomyolipomas (AMLs) without visible fat from renal cell carcinomas (RCCs)...
  6. ncbi Renal epithelioid angiomyolipoma: imaging characteristics in nine cases with radiologic-pathologic correlation and review of the literature
    Adam T Froemming
    Department of Radiology, Mayo Clinic, 200 1st St SE, Rochester, MN 55905, USA
    AJR Am J Roentgenol 200:W178-86. 2013
    The purpose of this study was to describe the imaging features of renal epithelioid angiomyolipoma (EAML), a rare subtype of angiomyolipoma, with clinical and pathologic correlation.
  7. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
    ..The drug sirolimus suppresses mTOR signaling...
  8. ncbi Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma
    C C Pan
    Department of Pathology, Taipei Veterans General Hospital and National Yang Ming University, Taiwan
    J Pathol 214:387-93. 2008
    Perivascular epithelioid cell tumours (PEComas) are a family of tumours including classic angiomyolipoma, lymphangioleiomyomatosis, and clear epithelioid cell tumours reported under a variety of names such as epithelioid angiomyolipoma, ..
  9. ncbi Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 225:78-82. 2002
    ..To evaluate the relationships between tumor size, aneurysm formation, and spontaneous rupture in renal angiomyolipomas...
  10. ncbi Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    Nisreen El-Hashemite
    Brigham and Women Hospital, Department of Medicine, Haematology Division, Boston MA 02115, USA
    Lancet 361:1348-9. 2003
    ..We suggest that treatment with rapamycin and its analogues could benefit such patients...
  11. ncbi Epithelioid angiomyolipoma of the kidney mimicking renal cell carcinoma: a clinicopathologic analysis of cases and literature review
    Chia Chun Tsai
    Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 25:133-40. 2009
    Classical renal angiomyolipoma (AML) is a common tumor that, in most cases, follows a benign course and has clearly defined radiologic and histological characteristics...
  12. ncbi Malignant epithelioid angiomyolipoma in the kidney and liver of a patient with pulmonary lymphangioleiomyomatosis: lack of response to sirolimus
    Futoshi Higa
    Department of Medicine and Therapeutics, Prevention, Control of Infectious Diseases, School of Medicine, University of the Ryukyus, Okinawa
    Intern Med 48:1821-5. 2009
    ..The pathological diagnosis of the tumor was conventional angiomyolipoma (AML). After 8 months, 2 liver tumors appeared and grew rapidly...
  13. ncbi PET scan with 11C-acetate for the imaging of liver masses: report of a false positive case
    R Lhommel
    Department of Nuclear Medicine, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Nucl Med Mol Imaging 32:629. 2005
  14. ncbi Renal epithelioid angiomyolipoma--a close mimic of renal cell carcinoma. Report of a case and review of the literature
    Alexandr Svec
    Department of Pathology, Faculty Hospital Královské Vinohrady and Third Medical Faculty, Charles University, Prague, Czech Republic
    Pathol Res Pract 200:851-6. 2005
    The epithelioid variant of angiomyolipoma (EAML) is a rare tumor of unpredictable behavior that is composed of epithelioid, spindle, and giant cells and contains no or only a minimal amount of lipomatous tissue...
  15. ncbi Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
    Jane Yu
    Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Am J Physiol Lung Cell Mol Physiol 286:L694-700. 2004
    ..Here, we report the first successful cell culture of a LAM-associated renal angiomyolipoma. The cells carried inactivating mutations in both alleles of the TSC2 gene and expressed estrogen receptor , ..
  16. pmc Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target
    Nisreen El-Hashemite
    Brigham and Women s Hospital, Hematology Division, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston MA 02115, USA
    Am J Respir Cell Mol Biol 33:227-30. 2005
    Pulmonary lymphangioleiomyomatosis (LAM) and renal angiomyolipoma (AML) are proliferative lesions that occur in sporadic patients, and at much higher frequency in patients with tuberous sclerosis (TSC)...
  17. ncbi Radiofrequency ablation (RFA) therapy for renal angiomyolipoma (AML): an alternative to angio-embolization and nephron-sparing surgery
    Scott M Castle
    Division of Endourology, Laparoscopy, and Minimally Invasive Surgery, Department of Urology, University of Miami Miller School of Medicine, FL 33136, USA
    BJU Int 109:384-7. 2012
    To show that radiofrequency ablation (RFA) is safe and effective treatment for renal angiomyolipoma (AML). Current treatments to reduce the risk of haemorrhage include tumour extirpation, angio-embolization, or ablative therapy.
  18. ncbi Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm
    Chin Chen Pan
    Department of Pathology, National Yang Ming University, Taipei, Taiwan Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
    Hum Pathol 37:606-12. 2006
    ..frequent deletion of 16p in which TSC2 gene is located indicates the oncogenetic relationship of PEComas with angiomyolipoma as a TSC2-linked neoplasm...
  19. pmc Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease
    Sandra L Dabora
    Biogen Idec Hemophilia, Weston, Massachusetts, United States of America
    PLoS ONE 6:e23379. 2011
    ..Tuberous sclerosis (TSC) related tumors are characterized by constitutively activated mTOR signaling due to mutations in TSC1 or TSC2...
  20. ncbi Invasive growth of hepatic angiomyolipoma; a hitherto unreported ominous histological feature
    A Nonomura
    Department of Diagnostic Pathology, Nara Medical University, School of Medicine, Kashihara, Nara, Japan
    Histopathology 48:831-5. 2006
    Although histological features of hepatic angiomyolipoma (AML) are highly variable, true malignant change is extremely rare...
  21. ncbi Diagnosis of renal angiomyolipoma with hounsfield unit thresholds: effect of size of region of interest and nephrographic phase imaging
    Matthew S Davenport
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 260:158-65. 2011
    To retrospectively determine the optimal Hounsfield unit threshold and region of interest (ROI) size required to accurately diagnose renal angiomyolipoma (AML) and differentiate it from renal cell carcinoma (RCC).
  22. ncbi Hepatic angiomyolipoma mimicking hepatic clear cell carcinoma
    P Chen
    Hepatobiliary Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    J Int Med Res 37:257-63. 2009
    b>Angiomyolipoma usually involves the kidney and rarely affects the liver. This study reports a case of angiomyolipoma of the liver in a 47-year-old Chinese woman. The patient did not present with abdominal pain and jaundice...
  23. ncbi Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumor
    Antonio D'Antonio
    Department of Pathologic Anatomy, AO San Giovanni di Dio e Ruggi d Aragona, Salerno, Italy
    Ann Diagn Pathol 13:347-50. 2009
    Epithelioid angiomyolipoma (AML) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis...
  24. ncbi Diagnosis and treatment of hepatic angiomyolipoma in 26 cases
    Ning Ren
    Liver Cancer Institute, Fudan University, Shanghai 200032, China
    World J Gastroenterol 9:1856-8. 2003
    To summarize the experience of the diagnosis and treatment of hepatic angiomyolipoma (HAML).
  25. ncbi Angiomyolipomata: challenges, solutions, and future prospects based on over 100 cases treated
    Prasanna Sooriakumaran
    Department of Urology, St George s Hospital, London, UK
    BJU Int 105:101-6. 2010
    To examine the presentation, management and outcomes of patients with renal angiomyolipoma (AML) over a period of 10 years, at St George's Hospital, London, UK.
  26. pmc Management of hepatic angiomyolipoma
    Ching Yao Yang
    Department of Surgery, National Taiwan University Hospital, and National Taiwan University College of Medicine, No 7 Chung Shan South Road, Taipei, 100, Taiwan
    J Gastrointest Surg 11:452-7. 2007
    Preoperative diagnosis of hepatic angiomyolipoma is difficult, and the treatment for it remains controversial...
  27. ncbi Pathological features of renal neoplasms classified by size and symptomatology
    Bruce Schlomer
    Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Urol 176:1317-20; discussion 1320. 2006
    ..We examined the relationship between tumor size and pathological findings in a contemporary series of surgical renal lesions and we characterized the relationship of incidental and symptomatic tumors to pathological findings...
  28. ncbi Hepatic angiomyolipoma
    Amber A Petrolla
    Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Arch Pathol Lab Med 132:1679-82. 2008
    Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females. Angiomyolipoma occurs most commonly in the kidneys...
  29. ncbi Reduction of postembolization syndrome after ablation of renal angiomyolipoma
    John J Bissler
    Division of Nephrology and Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Kidney Dis 39:966-71. 2002
    ..To reduce the risk of hemorrhage, transarterial embolization is used to necrose the angiomyolipoma while sparing normal renal tissue...
  30. ncbi Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas
    Victoria A Robb
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mod Pathol 19:839-46. 2006
    ..This high incidence of mTOR signaling pathway activation suggests that treatment with mTOR inhibitors, such as Rapamycin, may benefit patients with angiomyolipomas independent of the detection of TSC1/TSC2 loss of heterozygosity...
  31. ncbi Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging
    Alexander Kutikov
    Department of Surgery, Division of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Urology 68:737-40. 2006
    ..To determine the incidence of benign pathologic findings at partial nephrectomy for a solitary renal lesion when preoperative imaging is reviewed by an experienced team of academic genitourinary radiologists...
  32. ncbi Renal angiomyolipoma: clinicopathologic study of 194 cases with emphasis on the epithelioid histology and tuberous sclerosis association
    Hakan Aydin
    Department of Anatomic Pathology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
    Am J Surg Pathol 33:289-97. 2009
    The majority of renal angiomyolipoma (AML) is sporadic and occasionally it occurs as part of tuberous sclerosis complex (TSC)...
  33. ncbi The radiological diagnosis and treatment of renal angiomyolipoma-current status
    D Halpenny
    Department of Radiology, Adelaide and Meath Hospitals Incorporating the National Childrens Hospital, Tallaght, Dublin, Ireland
    Clin Radiol 65:99-108. 2010
    ..In addition, we discuss current guidelines for follow-up and prophylactic treatment of these lesions, as well as the increasing role that the interventional radiologist has to play in these cases...
  34. ncbi Low-dose rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex
    Ramón Peces
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Nephrol Dial Transplant 25:3787-91. 2010
    ..These data suggest that it could be the result of the anti-angiogenic, anti-fibrotic and anti-proliferative effects of rapamycin...
  35. ncbi Radiofrequency ablation for treatment of sporadic angiomyolipoma
    Warner Prevoo
    Department of Radiology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Urology 72:188-91. 2008
    Symptomatic angiomyolipoma (AML) and asymptomatic AML larger than 4 cm in size are usually treated with nephron-sparing surgery or arterial embolization...
  36. pmc PEComas: the past, the present and the future
    Guido Martignoni
    Department of Pathology, Universita di Verona, Verona, Italy
    Virchows Arch 452:119-32. 2008
    ..There are some open questions about PEComas regarding its histogenesis, the definition of epithelioid angiomyolipoma and the identification of the histological criteria of malignancy...
  37. pmc Epithelioid angiomyolipoma of the liver: cross-sectional imaging findings of 10 immunohistochemically-verified cases
    Peng ju Xu
    Department of Radiology, Zhongshan Hospital Fudan University, Shanghai 200032, China
    World J Gastroenterol 15:4576-81. 2009
    To retrospectively evaluate the computed tomography (CT)/magnetic resonance imaging (MRI) imaging features of epithelioid angiomyolipoma of the liver (Epi-HAML), with pathology as a reference.
  38. ncbi Angiomyolipoma with epithelial cysts of the kidney in a man
    Shuji Mikami
    Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan
    Pathol Int 58:664-7. 2008
    b>Angiomyolipoma (AML) is a well-characterized tumor composed of vascular, smooth muscle and adipose elements. Recently, AML with epithelial cysts (AMLEC) has been described as a cystic variant of AML...
  39. pmc Epithelioid angiomyolipoma: imaging appearances
    N Bharwani
    Department of Radiology, The Royal Marsden NHS Foundation Trust, London, UK
    Br J Radiol 82:e249-52. 2009
    Epithelioid angiomyolipoma is a recently described rare variant of renal angiomyolipoma. It can occur in patients with or without tuberous sclerosis, and may potentially be malignant...
  40. ncbi F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage
    Kentaro Takanami
    Department of Radiology, Graduate School of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Nucl Med 35:18-21. 2010
    ..This report demonstrates that benign hepatic AMLs may demonstrate increased FDG uptake if there is hemorrhage and a related inflammatory response...
  41. ncbi Angiomyolipoma with epithelial cysts: mimic of renal cell carcinoma
    Andrew B Rosenkrantz
    Department of Radiology, NYU Langone Medical Center, New York, NY 10016, USA
    Clin Imaging 34:65-8. 2010
    b>Angiomyolipoma with epithelial cysts (AMLEC) is a rare variant of angiomyolipoma with minimal fat that contains epithelial-lined cysts and may mimic a cystic renal cell carcinoma...
  42. ncbi Transarterial ethanol ablation for sporadic and non-hemorrhaging angiomyolipoma in the kidney
    Shigeo Takebayashi
    Department of Radiology, Yokohama City University Medical Center, 4 57, Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    Eur J Radiol 72:139-45. 2009
    ..We evaluated the efficacy and side effects of transarterial ethanol ablation in sporadic and non-hemorrhaging angiomyolipomas (AMLs) in the kidney...
  43. ncbi Epithelioid angiomyolipoma: a rare variant of renal angiomyolipoma
    Juan Carlos Astigueta
    Department of Urologic Surgery, Instituto Regional de Enfermedades Neoplásicas Norte, Trujillo, Peru
    Arch Esp Urol 62:493-7. 2009
    We present a case of primary renal epithelioid angiomyolipoma, its association with tuberous sclerosis and review the literature.
  44. ncbi Incidental angiomyolipoma resected during renal surgery for an enhancing renal mass
    Ryan K Berglund
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BJU Int 104:1650-4. 2009
    To review the outcomes of surgery for renal angiomyolipoma (AML, a benign renal neoplasm that often appears as an enhancing renal mass on imaging) removed at a centre that manages AML conservatively, as typically the presence of tumour ..
  45. ncbi Evaluation of renal function of angiomyolipoma patients after selective transcatheter arterial embolization
    Shen Yang Lee
    Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Am J Med Sci 337:103-8. 2009
    b>Angiomyolipoma patients may have renal insufficiency before selective transcatheter arterial embolization (TAE) or may undergo subsequent surgery after TAE...
  46. ncbi Renal angiomyolipoma with calcification: CT-pathology correlation
    S Merran
    FMP Département d Imagerie Médicale, Hôpital Cochin Service, 24 rue Saint Victor, 75005 Paris, France
    Br J Radiol 77:782-3. 2004
    ..We report a case of a fatty renal tumour with calcification which was an angiomyolipoma. The calcification within the tumour was secondary to osseous metaplasia.
  47. ncbi Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases
    Charles J Davis
    Department of Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 19:669-74. 2006
    ..a subepithelial collar of poorly differentiated cells, but the solid element of all tumors was myomatous angiomyolipoma; only one case had any adipose tissue...
  48. ncbi Epithelioid angiomyolipoma of the liver: case report and review of the literature
    Geir Tryggvason
    Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland
    APMIS 112:612-6. 2004
    Hepatic angiomyolipoma is a rare tumor. Here we describe a case and review the literature.
  49. ncbi Effects of rapamycin on angiomyolipomas in patients with tuberous sclerosis
    Cristina Cabrera López
    Nephrology Department, Puigvert Foundation, Autonomous University of Barcelona FP UAB Barcelona, Spain
    Nefrologia 31:292-8. 2011
    ..Constant and inadequate proliferation occurring in TS may be blocked by mTOR inhibitors (mammalian target of rapamycin), such as rapamycin...
  50. ncbi Epithelioid angiomyolipoma of the kidney
    Mustafa Fuat Acikalin
    Osmangazi University Medical Faculty, Department of Pathology, Eskisehir, Turkey
    Int J Urol 12:204-7. 2005
    Epithelioid angiomyolipoma is a recently recognized variant of angiomyolipoma, which is characterized by the presence of polygonal cells with densely eosinophilic cytoplasm and varying degrees of nuclear atypia...
  51. pmc The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells
    Elena Lesma
    Laboratory of Pharmacology, Dept of Medicine, Surgery, and Dentistry, Via A Di Rudini 8, 20142 Milano, Italy
    Am J Pathol 174:2150-9. 2009
    ..Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC...
  52. ncbi Massive epithelioid angiomyolipoma of the kidney in a young girl
    Ming Shan Hung
    Division of Urology, Changhua Christian Hospital, Changhua, Taiwan
    Int J Urol 12:998-1000. 2005
    ..Pathologic evaluation with HMB-45 immunohistochemical staining confirmed the diagnosis of epithelioid angiomyolipoma. The tumor consisted predominantly of epithelioid cells, and it could easily be misidentified as a renal cell ..
  53. ncbi Perivascular epithelioid cell sarcoma (malignant PEComa) of the ileum
    A Agaimy
    Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
    Pathol Res Pract 202:37-41. 2006
    Epithelioid angiomyolipoma (AML) is the prototype of a heterogeneous group of lesions characterized by the presence of HMB-45 positive cells with clear cytoplasm, perivascular distribution, and combined myomelanocytic features, so-called ..
  54. pmc Angiomyolipoma have common mutations in TSC2 but no other common genetic events
    Wei Qin
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24919. 2011
    Renal angiomyolipoma are part of the PEComa family of neoplasms, and occur both in association with Tuberous Sclerosis Complex (TSC) and independent of that disorder...
  55. ncbi Renal angiomyolipoma: growth followed up with CT and/or US
    L Lemaitre
    Department of Radiology, Hopital Claude Huriez, Centre Hospitalier Regional Universitaire CHRU, Lille, France
    Radiology 197:598-602. 1995
    ..To follow up the growth of renal angiomyolipomas (AMLs)...
  56. ncbi Dual-tracer PET/CT in renal angiomyolipoma and subtypes of renal cell carcinoma
    Chi lai Ho
    Department of Nuclear Medicine and PET, Hong Kong Sanatorium and Hospital, Hong Kong, China
    Clin Nucl Med 37:1075-82. 2012
    We studied the metabolic characteristics of RCC subtypes and angiomyolipoma with 18F-FDG and 11C-acetate PET/CT.
  57. ncbi Contemporary experience in the management of angiomyolipoma
    Adam C Mues
    Department of Urology, Columbia University Medical Center, New York, New York, USA
    J Endourol 24:1883-6. 2010
    We review our single center experience in the management of renal angiomyolipoma (AML) in patients who were treated with active surveillance (AS) or invasive treatment protocols.
  58. ncbi Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography: utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    Urology 81:1265-71. 2013
    ..To analyze the enhancement patterns of small renal masses (SRMs) during 4-phase computed tomography (CT) imaging to predict histology...
  59. ncbi Thoracic spinal angiomyolipoma with extracanal extension to the thoracic cavity. A case report
    H Sakaida
    Department of Neurosurgery, Mie University School of Medicine, Japan
    Spine (Phila Pa 1976) 23:391-4. 1998
    ..OBJECTIVE: To describe a 72-year-old man with thoracic spinal angiomyolipoma in the ventral aspect of the epidural space and extracanal extension to the posterior mediastinum, to discuss ..
  60. ncbi Dramatic tumor response to everolimus for malignant epithelioid angiomyolipoma
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
    Jpn J Clin Oncol 41:814-6. 2011
    Malignant epithelioid variant of angiomyolipoma has aggressive characteristics, against which conventional cytotoxic agents have been reported to be disappointingly inactive, and the prognosis of unresectable or recurrent disease is ..
  61. ncbi Expression of E-cadherin in angiomyolipoma
    Zhen Wang
    Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Hum Pathol 43:2348-53. 2012
    b>Angiomyolipoma is the most common member of perivascular epithelioid cell tumors that characteristically express myogenic and melanocytic markers...
  62. ncbi Minimal fat renal angiomyolipoma: the initial study with contrast-enhanced ultrasonography
    Qing Lu
    Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai, China
    Ultrasound Med Biol 38:1896-901. 2012
    ..0% and 97.2%, respectively. Slow centripetal enhancement in the cortical phase and homogeneous enhancement at peak are main features of CEUS-confirmed solid minimal fat renal AML...
  63. ncbi Histogram analysis of small solid renal masses: differentiating minimal fat angiomyolipoma from renal cell carcinoma
    Humaira S Chaudhry
    Department of Radiology, Division of Abdominal Imaging, Duke University Medical Center, Durham, NC, USA
    AJR Am J Roentgenol 198:377-83. 2012
    The objective of our study was to retrospectively determine whether minimal fat renal angiomyolipoma can be differentiated from clear cell or papillary renal cell carcinoma (RCC) in small renal masses using attenuation measurement ..
  64. ncbi Epithelioid angiomyolipoma: a morphologically distinct variant that mimics a variety of intra-abdominal neoplasms
    Ozgur Mete
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    Arch Pathol Lab Med 135:665-70. 2011
    ..the histopathologic, immunohistochemical, ultrastructural, and molecular biologic features of epithelioid angiomyolipoma (EAML), with an emphasis on the differential diagnosis of intra-abdominal EAML...
  65. ncbi Radiofrequency ablation of large renal angiomyolipoma: median-term follow-up
    S M Gregory
    Department of Radiology, St George s Hospital and Medical School, Blackshaw Road, London, SW17 0QT, UK
    Cardiovasc Intervent Radiol 36:682-9. 2013
    ..To study the feasibility of percutaneous radiofrequency ablation (RFA) of large angiomyolipomas (AMLs) using saline-cooled electrodes...
  66. ncbi Renal cell carcinoma and renal angiomyolipoma: differential diagnosis with real-time contrast-enhanced ultrasonography
    Zuo Feng Xu
    Department of Medical Ultrasonics, First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat Sen University, Guangzhou, China
    J Ultrasound Med 29:709-17. 2010
    The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in differentiating renal cell carcinoma (RCC) from renal angiomyolipoma (RAML).
  67. ncbi Expression of KIT (CD117) in angiomyolipoma
    Hala R Makhlouf
    Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 26:493-7. 2002
    b>Angiomyolipoma is a unique mesenchymal tumor postulated to arise from perivascular epithelioid cells...
  68. ncbi Renal epithelioid angiomyolipoma with atypia: a series of 40 cases with emphasis on clinicopathologic prognostic indicators of malignancy
    Fadi Brimo
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Surg Pathol 34:715-22. 2010
    ..This model accurately categorized 78% of clinically malignant and 100% of the clinically benign epithelioid AMLs with atypia...
  69. ncbi Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma
    Debbie Clements
    Division of Therapeutics and Molecular Medicine and National Institute for Health Research Respiratory Biomedical Research Unit, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham, United Kingdom
    J Immunol 185:1812-21. 2010
    ..a progressive disease caused by accumulation of metastatic (LAM) cells in the lungs, lymphatics, and the tumor angiomyolipoma (AML)...
  70. pmc Renal cell carcinoma containing macroscopic fat on CT mimics an angiomyolipoma due to bone metaplasia without macroscopic calcification
    L Richmond
    Department of Medical Imaging, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Br J Radiol 83:e179-81. 2010
    ..is significant because standard imaging practice is to classify a renal mass containing intratumoral macroscopic fat that is not associated with calcification, ossification or invasion of perirenal or hilar fat as an angiomyolipoma.
  71. ncbi Trabecular angiomyolipoma mimicking hepatic cell carcinoma
    E Szekely
    Semmelweis University, 2nd Department of Pathology, Budapest, H 1091, Hungary
    Pathol Oncol Res 6:224-6. 2000
    ..Histological examination found an angiomyolipoma of the above-mentioned type, and the final diagnosis was ascertained with the aid of vimentin, smooth muscle ..
  72. ncbi Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at biphasic helical CT
    Jeong Kon Kim
    Department of Radiology, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, Korea
    Radiology 230:677-84. 2004
    To compare various computed tomographic (CT) features of angiomyolipoma (AML) with minimal fat with those of size-matched renal cell carcinoma (RCC).
  73. ncbi Monotypic epithelioid angiomyolipoma of the liver
    S Yamasaki
    Department of First Pathology, Juntendo University, School of Medicine, Tokyo, Japan
    Histopathology 36:451-6. 2000
    Monotypic epithelioid angiomyolipoma is a recently recognized renal tumour, which is composed purely of epithelioid cells coexpressing markers of both smooth muscle differentiation and melanogenesis (HMB45)...
  74. pmc A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells
    Benoit Boivin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 2208, USA
    Proc Natl Acad Sci U S A 105:9959-64. 2008
    ..this cysteinyl-labeling assay to the study of platelet-derived growth factor (PDGF) receptor signaling in an angiomyolipoma cell model...
  75. ncbi Renal angiomyolipoma with minimal fat: differentiation from other neoplasms at double-echo chemical shift FLASH MR imaging
    Jeong Kon Kim
    Departments of Radiology and Urology, Asan Medical Center, University of Ulsan, 388 1 Poongnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Radiology 239:174-80. 2006
    ..of double-echo gradient-echo (GRE) chemical shift magnetic resonance (MR) imaging in the differentiation of angiomyolipoma (AML) with minimal fat from other renal neoplasms, with pathologic examination or follow-up data serving as ..
  76. ncbi [Angiomyolipoma of the colon - case report and review of the literature]
    J Pelz
    Chirurgische Klinik mit Poliklinik der Friedrich Alexander Universität Erlangen Nürnberg, Germany
    Z Gastroenterol 41:715-8. 2003
    b>Angiomyolipoma is one of the benign hamartomas that is found sporadically or associated with tuberous sclerosis. It is a rare soft tissue tumor involving mostly the kidneys, sometimes other visceral organs...
  77. ncbi Fine-needle aspiration of renal angiomyolipoma: a report of four cases
    U Handa
    Department of Pathology, Government Medical College and Hospital, Sector 32A, Chandigarh, India
    Cytopathology 18:250-4. 2007
    Renal angiomyolipoma is an uncommon benign tumour composed of smooth muscle cells, blood vessels and adipose tissue. The cytological findings of this tumour are described.
  78. ncbi Epithelioid angiomyolipoma of the liver with striking giant cell component: fine-needle aspiration biopsy findings of a rare neoplasm
    Houda Alatassi
    Division of Cytopathology, Department of Pathology, University of Louisville, Louisville, Kentucky 40202, USA
    Diagn Cytopathol 37:192-4. 2009
    b>Angiomyolipoma (AML) is a uncommon benign neoplasm of the liver with cyto- and histologic features similar to the more commonly encountered renal AML...
  79. ncbi Lymph nodal involvement by renal angiomyolipoma
    I Türker Köksal
    Department of Urology, Faculty of Medicine, Istanbul University, Turkey
    Int J Urol 7:386-9. 2000
    b>Angiomyolipoma of the kidney is a clonal neoplasm, apparently part of a family of neoplasms derived from perivascular epithelial cells. A 40-year-old woman presented with right flank pain and an otherwise non-significant medical history...
  80. ncbi Angiomyolipoma of the colon: report of a case and review of the literature
    Jinn Shiun Chen
    Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan
    Dis Colon Rectum 46:547-9. 2003
    b>Angiomyolipoma of the colon is very rare. Only three cases have been reported in the literature. Here we report the case of a 54-year-old male, who presented with a progressive abdominal cramping pain...
  81. ncbi Renal angiomyolipoma extending into the right atrium
    M I Davydov
    Department of Thoracoabdominal Surgery, Cancer Research Center, Moscow, Russia
    Urol Int 67:168-9. 2001
    ..We describe the diagnosis and management of a rare case of AML associated with tumor thrombus extending into the right atrium...
  82. ncbi Angiomyolipoma of the anterior mediastinum
    Carrie S Knight
    Department of Pathology, University of Alabama School of Medicine, Birmingham, AL, USA
    Ann Diagn Pathol 12:293-5. 2008
    b>Angiomyolipoma is a benign tumor composed of varying proportions of smooth muscle cells, blood vessels, and adipose tissue that most commonly occurs in the kidney...
  83. ncbi Paradoxical carbon dioxide embolism during pneumoperitoneum in laparoscopic surgery for a huge renal angiomyolipoma
    Yu Yin Huang
    Department of Anesthesiology, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan, R O C
    J Chin Med Assoc 71:214-7. 2008
    ..a case of paradoxical gas embolism during CO2 insufflation in laparoscopic nephrectomy for a huge renal angiomyolipoma. Paradoxical CO2 embolism in the left heart chambers without demonstrable intracardiac right-to-left shunt was ..
  84. ncbi Nephron-sparing nephrectomy for giant renal angiomyolipoma associated with lymphangioleiomyomatosis
    Thomas H S Hsu
    Section of Urologic Oncology, Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 59:138. 2002
    ..We describe successful nephron-sparing surgery for a giant angiomyolipoma and discuss relevant management issues in a patient with lymphangioleiomyomatosis who had previously undergone ..
  85. ncbi Embolization of a bleeding renal angiomyolipoma in pregnancy: case report and review
    Jose P Morales
    Department of Interventional Radiology, Guy s and St Thomas Hospital, St Thomas Street, London SE1 9RT, UK
    Cardiovasc Intervent Radiol 28:265-8. 2005
    A case is described of a woman 10 weeks pregnant who had severe bleeding, secondary to a renal angiomyolipoma (AML), that was treated with embolization...
  86. ncbi Renal angiomyolipoma during pregnancy: review of the literature
    Ignacio Zapardiel
    Obstetrics and Gynecology Department, Santa Cristina University Hospital, Madrid, Spain
    Gynecol Obstet Invest 72:217-9. 2011
    The incidence of renal angiomyolipoma (RA) is 0.3% in the general population, and even more infrequent during pregnancy. Pregnancy can increase the risk of rupture, although the causal mechanism is still not clearly defined...
  87. ncbi Malignant epithelioid angiomyolipoma of the kidney in a patient with tuberous sclerosis: an autopsy case report with p53 gene mutation analysis
    Katsuaki Sato
    Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku, Ishikawa 920 0293, Japan
    Pathol Res Pract 204:771-7. 2008
    We report an autopsy case of malignant epithelioid angiomyolipoma in a 36-year-old male tuberous sclerosis patient. He had been diagnosed to have a bilateral renal tumor 20 years previously...
  88. ncbi [Malignant-like angiomyolipoma of the liver: report of one case and review of the literature]
    D Rouquie
    Service de Chirurgie Viscérale et Vasculaire, Hopital du Val de Grace, 74, boulevard Port Royal, 75230 Paris Cedex 05, France
    Ann Chir 131:338-41. 2006
    Frequently found in kidney, angiomyolipoma is a rare mesenchymal tumor when diagnosed in the liver and usually benign composed of proliferative blood vessels, fatty tissue and smooth muscle...
  89. ncbi An unusual renal angiomyolipoma with morphological lymphangioleiomyomatosis features and coexpression of oestrogen and progesterone receptors
    Magali Colombat
    Service d Anatomie Pathologique, Centre Hospitalier General, Saint Quentin, France
    Virchows Arch 440:102-4. 2002
    b>Angiomyolipoma is the most common mesenchymal renal tumour, the clonal origin of which has recently been demonstrated. It is composed of varying amounts of blood vessels, smooth muscle and fat...
  90. ncbi Inflammatory angiomyolipomas of the liver: a clinicopathologic and immunohistochemical analysis of 5 cases
    Huaiyin Shi
    Department of Pathology, The Chinese PLA General Hospital, Beijing 100853, China
    Ann Diagn Pathol 14:240-6. 2010
    Hepatic angiomyolipoma (AML) may demonstrate a marked histologic diversity. We report 5 cases of hepatic AML exhibiting prominent inflammatory cells in the background (inflammatory AML)...
  91. ncbi Angiomyolipoma with minimal fat on MDCT: can counts of negative-attenuation pixels aid diagnosis?
    Claus Simpfendorfer
    Section of Abdominal Imaging, Imaging Institute, Desk Hb6, Cleveland Clinic, Cleveland, OH 44195, USA
    AJR Am J Roentgenol 192:438-43. 2009
    The purpose of this study was to determine whether counts of pixels with subzero attenuation on CT scans can aid in the diagnosis of renal angiomyolipoma with minimal fat.
  92. pmc Inflammatory angiomyolipoma of the liver: a rare hepatic tumor
    Yang Liu
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China
    Diagn Pathol 7:122. 2012
    b>Angiomyolipoma (AML) is a rare mesenchymal neoplasm of the tumor, composed of a varying heterogeneous mixture of three tissue components: blood vessels, smooth muscle and adipose cells...
  93. ncbi Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography
    Wenbo Xiao
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Radiology, Hangzhou, China
    Abdom Imaging 35:203-7. 2010
    ..of our study was to describe contrast-enhanced magnetic resonance angiography (MRA) findings of hepatic angiomyolipoma (AML) with less lipocyte...
  94. ncbi Renal cell carcinomas with intratumoral fat and concomitant angiomyolipoma: potential pitfalls in staging and diagnosis
    Manju Aron
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, L25, Cleveland, OH 44195, USA
    Am J Clin Pathol 134:807-12. 2010
    ..Our study highlights the potential pitfalls in staging and diagnosis when intratumoral fat or AML is found within RCC...
  95. ncbi Epithelioid angiomyolipoma of the kidney
    Ikuma Kato
    Division of Anatomical and Surgical Pathology, Yokohama City University Hospital, Yokohama, Japan
    Pathol Int 59:38-43. 2009
    Epithelioid angiomyolipoma (eAMLoma) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis (TSC)...
  96. ncbi Controversies related to epithelioid variant of renal angiomyolipoma: a review of the literature
    Patricia Serrano Frago
    Servicio de Urologia, Hospital Universitario Miguel Servet, Zaragoza, Spain
    Urology 67:846.e3-5. 2006
    ..adrenal carcinoma suggested by computed tomography for whom the histopathologic study revealed an epithelioid angiomyolipoma arising from the kidney...
  97. ncbi Diffusion-weighted magnetic resonance imaging in the differentiation of angiomyolipoma with minimal fat from clear cell renal cell carcinoma
    Hajime Tanaka
    Department of Urology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Urol 18:727-30. 2011
    ..to evaluate diffusion-weighted (DW) magnetic resonance imaging (MRI) in differentiating between minimal fat angiomyolipoma (MFAML) and clear cell renal cell carcinoma (CCRCC)...
  98. ncbi Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma
    D Högemann
    Department of Radiology, Hannover Medical School, Germany
    Eur Radiol 11:1389-95. 2001
    ..Predominantly, CT and MRI did not include angiomyolipoma in the differential diagnosis, and the initial histopathological evaluation was inconclusive in more than half ..
  99. ncbi Angiomyolipoma of the large intestine: report of a case
    H Maluf
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Mod Pathol 12:1132-6. 1999
    A case of an angiomyolipoma of the large intestine occurring in a 55-year-old man without evidence of tuberous sclerosis is reported. Endoscopically, the lesion resembled a sessile adenomatous polyp. The tumor measured 1 cm...
  100. ncbi Sonographic appearance of a cholesterol granuloma within a renal epithelioid angiomyolipoma
    Kai Lun Cheng
    Department of Medical Imaging, Chung Shan Medical University Hospital, No 110, Section 1, Chien Kuo N Rd, Taichung, Taiwan 402, Republic of China
    J Clin Ultrasound 39:95-8. 2011
    We present the sonographic characteristics of a rare case of cholesterol granuloma within a renal epithelioid angiomyolipoma (AML) in a 57-year-old woman...
  101. ncbi Angiomyolipoma of the kidney: expanding disease spectrum demonstrated by 3 cases
    Shahin Chandrasoma
    Department of Urology, University of Southern California, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Appl Immunohistochem Mol Morphol 12:277-83. 2004
    We report 3 recent cases of angiomyolipoma of the kidney. Although generally regarded as a benign neoplasm, angiomyolipoma rarely behaves in an aggressive manner, producing complicated clinical courses leading to metastasis and death...

Research Grants12

  1. Roles of autophagy-mediated pathways in the pathogenesis and treatment of TSC
    Elizabeth P Henske; Fiscal Year: 2013
    ..Our in vivo strategy (Aims 2 and 3) includes TSC2-deficient angiomyolipoma-derived cells and renal cyst/cystadenoma quantitation in Tsc2+/- mice...
  2. Magnetic Resonance Spectroscopy of Tumors and Tissues
    Pamela Nurenberg; Fiscal Year: 2002
    ..a specific metabolic "fingerprint"/ pattern that differentiates RCC from benign tumors such as oncocytoma, and angiomyolipoma, and from other malignant lesions such as lymphoma, transitional cell carcinoma, and metastasis. C...
  3. Whole cell panning; identification of markers to TSC
    JONATHAN ROTHBERG; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): We describe the development of human renal angiomyolipoma (AML) cell lines with which to provide an in vitro cellular model for use in identifying molecular markers of Tuberous Sclerosis ..
  4. DNA Replication Fork: Pausing, Recombination and Disease
    John Bissler; Fiscal Year: 2007
    ..By understanding the effects of these sequences on the fidelity of DNA replication, therapeutic inroads into delaying disease onset can be made. ..
  5. Utility of Rapamycin for the Treatment of Renal Angiomy*
    John Bissler; Fiscal Year: 2004
    ..The minimal rapamycin dose that produces an effect, defined as a greater than 10% decrease in angiomyolipoma volume, will be titrated beginning with doses that result in subimmunosuppressive serum levels to those that ..
  6. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  7. Roles of Tuberin (TSC2), Hamartin (TSC1), and Rheb in Renal Cyst Pathogenesis
    Elizabeth P Henske; Fiscal Year: 2010
    ....
  8. Regulation of Estrogen Signaling by Tuberin and Rheb
    Elizabeth P Henske; Fiscal Year: 2010
    ..The results of this project will elucidate the cause of a female-predominant disease, lymphangiomyomatosis (LAM), and may also contribute to our understanding of other estrogen-linked diseases. ..
  9. MOLECULAR BASIS OF LYMPHANGIOMYOMATOSIS
    ELIZABETH HENSKE; Fiscal Year: 2006
    ..LAM cells from women with sporadic LAM, but not in normal kidney or lung, which strongly suggests that LAM and angiomyolipoma cells are derived from the same cell...
  10. Mechanisms of Renal Tumorigenesis in Tuberous Sclerosis
    ELIZABETH HENSKE; Fiscal Year: 2008
    ..The cellular and biochemical pathways that cause kidney disease in TSC are likely to be closely related to the pathways that cause kidney tumors and cysts in other individuals. ..
  11. A Schizosaccharomyces pombe Model of Birt-Hogg-Dube Syndrome
    ELIZABETH HENSKE; Fiscal Year: 2007
    ..Nothing is currently known about how BHD gene mutations lead to human disease. We will use a novel yeast model of BHD to elucidate the function of the BHD protein. ..
  12. NFAT and MEF-2 Choreograph Bladder Wall Remodeling Following Partial Outlet Obstr
    STEPHEN ANTHONY ZDERIC; Fiscal Year: 2010
    ..New therapy to preserve and enhance native bladder function will help avoid the development of the end stage bladder. ..