- A gene-expression signature as a predictor of survival in breast cancer
Marc J van de Vijver
Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
N Engl J Med 347:1999-2009. 2002
..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
- A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Richard M Neve
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94270, USA
Cancer Cell 10:515-27. 2006
..We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations...
- A pathway-based classification of human breast cancer
Michael L Gatza
Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 107:6994-9. 2010
..We propose that this classification scheme provides a basis for understanding the complex mechanisms of oncogenesis that give rise to these tumors and to identify rational opportunities for combination therapies...
- Molecular portraits of human breast tumours
C M Perou
Department of Genetics, Stanford University School of Medicine, California 94305, USA
Nature 406:747-52. 2000
..The tumours could be classified into subtypes distinguished by pervasive differences in their gene expression patterns...
- A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
N Engl J Med 351:2817-26. 2004
..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Nature 486:346-52. 2012
..Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome...
- An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Genet 40:499-507. 2008
- Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
Division of Hematology Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 366:520-9. 2012
..In early studies, the mTOR inhibitor everolimus added to endocrine therapy showed antitumor activity...
- Prospective identification of tumorigenic breast cancer cells
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:3983-8. 2003
..Furthermore, because these cells drive tumor development, strategies designed to target this population may lead to more effective therapies...
- Sequence analysis of mutations and translocations across breast cancer subtypes
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nature 486:405-9. 2012
..The MAGI3-AKT3 fusion leads to constitutive activation of AKT kinase, which is abolished by treatment with an ATP-competitive AKT small-molecule inhibitor...
- Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
International Breast Cancer Study Group, Department of Medicine, European Institute of Oncology, Milan, Italy
Ann Oncol 22:1736-47. 2011
..Broad treatment recommendations are presented, recognizing that detailed treatment decisions need to consider disease extent, host factors, patient preferences, and social and economic constraints...
- The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Philip A Gregory
Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
Nat Cell Biol 10:593-601. 2008
..Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. These data suggest that downregulation of the microRNAs may be an important step in tumour progression...
- Genes that mediate breast cancer metastasis to lung
Andy J Minn
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nature 436:518-24. 2005
..Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis...
- Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
D J Slamon
Department of Medicine, U C L A School of Medicine 90024
Science 244:707-12. 1989
..The data presented further support the concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers...
- The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P Shah
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Nature 486:395-9. 2012
..Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes...
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
Proc Natl Acad Sci U S A 98:10869-74. 2001
- Most random gene expression signatures are significantly associated with breast cancer outcome
IRIDIA CoDE, Universite Libre de Bruxelles, Brussels, Belgium
PLoS Comput Biol 7:e1002240. 2011
..The methods we present help to overcome this problem...
- Supervised risk predictor of breast cancer based on intrinsic subtypes
Joel S Parker
Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Clin Oncol 27:1160-7. 2009
..Test sets from 761 patients (no systemic therapy) were evaluated for prognosis, and 133 patients were evaluated for prediction of pathologic complete response (pCR) to a taxane and anthracycline regimen...
- Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F Tavazoie
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nature 451:147-52. 2008
..miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer...
- Association of reactive oxygen species levels and radioresistance in cancer stem cells
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 458:780-3. 2009
- The genomic landscapes of human breast and colorectal cancers
Laura D Wood
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
Science 318:1108-13. 2007
..These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy...
- Genome remodelling in a basal-like breast cancer metastasis and xenograft
The Genome Center at Washington University, St Louis, Missouri 63108, USA
Nature 464:999-1005. 2010
..The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within the primary tumour...
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
Brian D Lehmann
Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 121:2750-67. 2011
..These data may be useful in biomarker selection, drug discovery, and clinical trial design that will enable alignment of TNBC patients to appropriate targeted therapies...
- Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
M P Coleman
Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK
Lancet 377:127-38. 2011
..This is the first study in a programme to investigate international survival disparities, with the aim of informing health policy to raise standards and reduce inequalities in survival...
- PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Science 275:1943-7. 1997
..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
- Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
Piyush B Gupta
Broad Institute, Cambridge, MA 02142, USA
Cell 146:633-44. 2011
..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
- Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
Edward H Romond
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
N Engl J Med 353:1673-84. 2005
..We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer...
- Whole-genome analysis informs breast cancer response to aromatase inhibition
Matthew J Ellis
Department of Internal Medicine, Division of Oncology, Washington University, St Louis, Missouri 63110, USA
Nature 486:353-60. 2012
..Prospective clinical trials based on these findings will require comprehensive genome sequencing...
- let-7 regulates self renewal and tumorigenicity of breast cancer cells
Department of Breast Surgery, No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, People s Republic of China
Cell 131:1109-23. 2007
..Therefore let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target...
- A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132
Science 266:66-71. 1994
..Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology...
- Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
David G DeNardo
Department of Pathology, University of California, San Francisco, USA
Cancer Discov 1:54-67. 2011
- High frequency of mutations of the PIK3CA gene in human cancers
Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Science 304:554. 2004
- Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
Jacques E Rossouw
Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
JAMA 288:321-33. 2002
..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
- Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
Breast Center at Baylor College of Medicine, 1 Baylor Plaza BCM 600, TX 77030, USA
J Natl Cancer Inst 100:672-9. 2008
- Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis
Mohammad H Forouzanfar
Institute for Health Metrics and Evaluation, University of Washington, Seattle, USA
Lancet 378:1461-84. 2011
..Breast and cervical cancer are important causes of mortality in women aged ≥15 years. We undertook annual age-specific assessments of breast and cervical cancer in 187 countries...
- Genome-wide association study identifies five new breast cancer susceptibility loci
Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
Nat Genet 42:504-7. 2010
- Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Sohrab P Shah
Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, Canada
Nature 461:809-13. 2009
..Taken together, our data show that single nucleotide mutational heterogeneity can be a property of low or intermediate grade primary breast cancers and that significant evolution can occur with disease progression...
- Genes that mediate breast cancer metastasis to the brain
Paula D Bos
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nature 459:1005-9. 2009
..This co-option of a brain sialyltransferase highlights the role of cell-surface glycosylation in organ-specific metastatic interactions...
- Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
Clin Cancer Res 13:3207-14. 2007
..The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment...
- Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
N Engl J Med 343:78-85. 2000
..The contribution of hereditary factors to the causation of sporadic cancer is unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes to the development of malignant diseases...
- Stromal gene expression predicts clinical outcome in breast cancer
McGill Centre for Bioinformatics, 3775 University Street, McGill University, Quebec H3A 2B4, Canada
Nat Med 14:518-27. 2008
..Genes represented in the SDPP reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses, highlighting the importance of stromal biology in tumor progression...
- Complex landscapes of somatic rearrangement in human breast cancer genomes
Philip J Stephens
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nature 462:1005-10. 2009
..The study provides a new perspective on cancer genomes, highlighting the diversity of somatic rearrangements and their potential contribution to cancer development...
- Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
J Natl Cancer Inst 98:262-72. 2006
..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
- Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials
Clinical Trial Service Unit, Oxford, UK
Lancet 366:2087-106. 2005
..To examine this relationship, collaborative meta-analyses were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995...
- Tumour evolution inferred by single-cell sequencing
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Nature 472:90-4. 2011
..In contrast to gradual models of tumour progression, our data indicate that tumours grow by punctuated clonal expansions with few persistent intermediates...
- The landscape of cancer genes and mutational processes in breast cancer
Philip J Stephens
Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Nature 486:400-4. 2012
..Among the 100 tumours, we found driver mutations in at least 40 cancer genes and 73 different combinations of mutated cancer genes. The results highlight the substantial genetic diversity underlying this common disease...
- Diverse somatic mutation patterns and pathway alterations in human cancers
Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 466:869-73. 2010
..Our study provides an overview of the mutational spectra across major human cancers and identifies several potential therapeutic targets...
- Mutational processes molding the genomes of 21 breast cancers
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Cell 149:979-93. 2012
..The mechanisms underlying most of these mutational signatures are unknown. However, a role for the APOBEC family of cytidine deaminases is proposed...
- Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Caryn S Ross-Innes
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Nature 481:389-93. 2012
..By establishing transcription-factor mapping in primary tumour material, we show that there is plasticity in ER-binding capacity, with distinct combinations of cis-regulatory elements linked with the different clinical outcomes...
- Circulating microRNAs as novel minimally invasive biomarkers for breast cancer
Helen M Heneghan
Department of Surgery, National University of Ireland, Galway, Ireland
Ann Surg 251:499-505. 2010
..The objective of this study was to investigate the potential of circulating microRNAs as novel breast cancer biomarkers...
- Breast cancer statistics, 2011
Epidemiologist, Surveillance Research, American Cancer Society, Atlanta, GA 30303, USA
CA Cancer J Clin 61:409-18. 2011
..Continued progress in the control of breast cancer will require sustained and increased efforts to provide high-quality screening, diagnosis, and treatment to all segments of the population...
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Nat Med 15:907-13. 2009
..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
- Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212 5234, USA
N Engl J Med 347:1233-41. 2002
..In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer...
- Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Antoine E Karnoub
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nature 449:557-63. 2007
..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
- Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
Lancet 365:671-9. 2005
- Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009
International Breast Cancer Study Group, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
Ann Oncol 20:1319-29. 2009
..The threshold for indication of each systemic treatment modality thus depends on different criteria which have been separately listed to clarify the therapeutic decision-making algorithm...
- Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression
Douglas S Micalizzi
Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Mammary Gland Biol Neoplasia 15:117-34. 2010
..This review focuses on the parallels between epithelial plasticity/EMT in the mammary gland and other organs during development, and on a selection of developmental EMT regulators that are misexpressed specifically during breast cancer...
- Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
Breast Cancer Res 12:R68. 2010
..Here, we comprehensively characterize the recently identified claudin-low tumor subtype...
- Circulating tumor cells, disease progression, and survival in metastatic breast cancer
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
N Engl J Med 351:781-91. 2004
..We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer...
- A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 137:1032-46. 2009
..Indeed, RhoA re-expression partially reverses miR-31-imposed metastasis suppression. These findings indicate that miR-31 uses multiple mechanisms to oppose metastasis...
- American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
M Elizabeth H Hammond
Intermountain Healthcare, University of Utah School of Medicine, Salt Lake City, UT, USA
J Clin Oncol 28:2784-95. 2010
..To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers...
- Repeated observation of breast tumor subtypes in independent gene expression data sets
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 100:8418-23. 2003
..Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities...
- Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA
Cell 138:592-603. 2009
..The coordinated downregulation of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c provide a molecular link that connects BCSCs with normal stem cells...
- Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer
Maggie C U Cheang
Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, BC, Canada
J Natl Cancer Inst 101:736-50. 2009
- Triple-negative breast cancer: clinical features and patterns of recurrence
Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
Clin Cancer Res 13:4429-34. 2007
..To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer...
- The life history of 21 breast cancers
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Cell 149:994-1007. 2012
..Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis...
- American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
Yale Cancer Center, Yale University, New Haven, CT, USA
J Clin Oncol 25:5287-312. 2007
..To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of breast cancer...
- Matrix crosslinking forces tumor progression by enhancing integrin signaling
Kandice R Levental
Department of Bioengineering and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 139:891-906. 2009
..These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy...
- Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
Lisa B Frankel
Biotech Research and Innovation Centre, Bioinformatics Centre, University of Copenhagen, DK 2200 N Copenhagen, Denmark
J Biol Chem 283:1026-33. 2008
..We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells...
- miR-21-mediated tumor growth
M L Si
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Oncogene 26:2799-803. 2007
..Together, these results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target...
- MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
Tyler E Miller
Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 283:29897-903. 2008
..This finding also provides the rationale for the application of altered expression of specific miRNAs as a predictive tamoxifen-resistant breast cancer marker...
- microRNAs exhibit high frequency genomic alterations in human cancer
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:9136-41. 2006
..These findings support the notion that copy number alterations of miRNAs and their regulatory genes are highly prevalent in cancer and may account partly for the frequent miRNA gene deregulation reported in several tumor types...
- Triple-negative breast cancer
William D Foulkes
Departmentof Oncology and Human Genetics, Research Institute of the McGill University Health Centre, and the Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H2W 1S6, Canada
N Engl J Med 363:1938-48. 2010
..This review focuses on its origin, molecular and clinical characteristics, and treatment...
- MicroRNA gene expression deregulation in human breast cancer
Marilena V Iorio
Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 65:7065-70. 2005
..We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index...
- Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
Centre de Recherche en Cancerologie de Marseille, Laboratoire d Oncologie Moleculaire, UMR891 Inserm Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
Cancer Res 69:1302-13. 2009
- A multigenic program mediating breast cancer metastasis to bone
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Cancer Cell 3:537-49. 2003
- American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
Antonio C Wolff
American Society of Clinical Oncology, Alexandria, VA and the College of American Pathologists, Northfield, IL, USA
Arch Pathol Lab Med 131:18-43. 2007
..To develop a guideline to improve the accuracy of human epidermal growth factor receptor 2(HER2) testing in invasive breast cancer and its utility as a predictive marker...
- Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
Swiss Institute of Bioinformatics, Batiment Genopode, University of Lausanne, 1015 Lausanne, Switzerland
Breast Cancer Res 10:R65. 2008
- Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
Charles L Vogel
University of Miami School of Medicine, Comprehensive Cancer Research Group Inc, and Columbia Cancer Research Network of Florida, Miami, FL, USA
J Clin Oncol 20:719-26. 2002
..To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with HER2-overexpressing metastatic breast cancer...
- The Ki-67 protein: from the known and the unknown
Division of Molecular Immunology, Research Center Borstel, Germany
J Cell Physiol 182:311-22. 2000
..There are indications, however, that Ki-67 protein expression is an absolute requirement for progression through the cell-division cycle...
- An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
Joint Research Laboratory of the Hungarian Academy of Sciences and the Semmelweis University, Semmelweis University 1st Department of Pediatrics, Bókay u 53 54, 1083, Budapest, Hungary
Breast Cancer Res Treat 123:725-31. 2010
..The tool is highly valuable for the preliminary assessment of biomarkers, especially for research groups with limited bioinformatic resources...
- Induction of autophagy and inhibition of tumorigenesis by beclin 1
X H Liang
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nature 402:672-6. 1999
..These findings suggest that decreased expression of autophagy proteins may contribute to the development or progression of breast and other human malignancies...
- Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
Jason I Herschkowitz
Lineberger Comprehensive Cancer Center
Genome Biol 8:R76. 2007
..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
- ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Cell Stem Cell 1:555-67. 2007
..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
- The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
Tiffany M Phillips
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
J Natl Cancer Inst 98:1777-85. 2006
..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
- Trastuzumab--mechanism of action and use in clinical practice
Clifford A Hudis
Breast Cancer Medicine Service, Solid Tumor Division, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
N Engl J Med 357:39-51. 2007
- The consensus coding sequences of human breast and colorectal cancers
Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Science 314:268-74. 2006
..These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology...
- A systems biology approach for pathway level analysis
Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48202, USA
Genome Res 17:1537-45. 2007
..This analysis method has been implemented as a Web-based tool, Pathway-Express, freely available as part of the Onto-Tools (http://vortex.cs.wayne.edu)...
- Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
D J Slamon
Science 235:177-82. 1987
..These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of human breast cancer...
- Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Cell 117:927-39. 2004
..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
- Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer
Kenneth R Hess
Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
J Clin Oncol 24:4236-44. 2006
..We developed a multigene predictor of pathologic complete response (pCR) to preoperative weekly paclitaxel and fluorouracil-doxorubicin-cyclophosphamide (T/FAC) chemotherapy and assessed its predictive accuracy on independent cases...
- Multidrug resistance in cancer: role of ATP-dependent transporters
Michael M Gottesman
Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Cancer 2:48-58. 2002
..Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy...
- Generation of breast cancer stem cells through epithelial-mesenchymal transition
Anne Pierre Morel
Centre Leon Berard, Lyon, France
PLoS ONE 3:e2888. 2008
..The acquisition of these stem and tumorigenic characters is driven by EMT induction...
- Involvement of chemokine receptors in breast cancer metastasis
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
Nature 410:50-6. 2001
..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
- Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
Chad J Creighton
Department of Molecular and Cellular Biology, Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 106:13820-5. 2009
..Targeting proteins involved in EMT may provide a therapeutic strategy for eliminating surviving cells to prevent recurrence and improve long-term survival in breast cancer patients...
- Systemic spread is an early step in breast cancer
Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
Cancer Cell 13:58-68. 2008
..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis...
- Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group
Department of Biochemistry, Royal Marsden Hospital and Breakthrough Breast Cancer Centre, Fulham Road, London, UK
J Natl Cancer Inst 103:1656-64. 2011
..These recommendations are geared toward achieving a harmonized methodology, create greater between-laboratory and between-study comparability, and allow earlier valid applications of this marker in clinical practice...
- Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
Jules Bordet Institute Machine Learning Group, Universite Libre de Bruxelles, Brussels, Belgium
J Clin Oncol 25:1239-46. 2007
..However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER) -positive subtypes has been inconsistent. Therefore, refinement of their molecular definition is needed...
- Metastatic behavior of breast cancer subtypes
Vancouver Clinic, Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
J Clin Oncol 28:3271-7. 2010
..Prognostic and predictive factors are well established in early-stage breast cancer, but less is known about which metastatic sites will be affected...
- Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
Maggie C U Cheang
Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada
Clin Cancer Res 14:1368-76. 2008
..This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of breast tumors...
- A microRNA signature of hypoxia
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Mol Cell Biol 27:1859-67. 2007
..Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors...