spinal neoplasms

Summary

Top Publications

  1. ncbi Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors
    K Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Spine (Phila Pa 1976) 22:324-33. 1997
  2. ncbi Suspected metastatic coccygeal chordoma in a ferret (Mustela putorius furo)
    John S Munday
    Athens Diagnostic Laboratory and Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Diagn Invest 16:454-8. 2004
  3. ncbi Instability and impending instability of the thoracolumbar spine in patients with spinal metastases: a systematic review
    Michael H Weber
    Division of Spine, Department of Orthopaedics, University of British Columbia, Blusson Spinal Cord Centre, 6th Floor, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada
    Int J Oncol 38:5-12. 2011
  4. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
  5. pmc Total en bloc spondylectomy for spinal tumors: improvement of the technique and its associated basic background
    Katsuro Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    J Orthop Sci 11:3-12. 2006
  6. ncbi Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
  7. ncbi Spinal metastases: the obvious, the occult, and the impostors
    D A Wong
    Department of Orthopedic Surgery, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 15:1-4. 1990
  8. ncbi Impact of surgical intervention on quality of life in patients with spinal metastases
    Alexis Falicov
    Vancouver Spine Program, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 31:2849-56. 2006
  9. ncbi Primary vertebral tumors: a review of epidemiologic, histological, and imaging findings, Part I: benign tumors
    Alexander E Ropper
    Department of Neurosurgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 69:1171-80. 2011
  10. ncbi Total en bloc spondylectomy for spinal tumors: surgical techniques and related basic background
    Norio Kawahara
    Department of Orthopedic Surgery, Graduate School of Medical Science Kanazawa University, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Orthop Clin North Am 40:47-63, vi. 2009

Detail Information

Publications297 found, 100 shown here

  1. ncbi Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors
    K Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Spine (Phila Pa 1976) 22:324-33. 1997
    ..The "total en bloc spondylectomy" offers one of the most aggressive modes of therapy for primary spinal malignancy...
  2. ncbi Suspected metastatic coccygeal chordoma in a ferret (Mustela putorius furo)
    John S Munday
    Athens Diagnostic Laboratory and Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Diagn Invest 16:454-8. 2004
    ..Observations from this case suggest that chordomas in ferrets may have metastatic potential and so should be removed promptly...
  3. ncbi Instability and impending instability of the thoracolumbar spine in patients with spinal metastases: a systematic review
    Michael H Weber
    Division of Spine, Department of Orthopaedics, University of British Columbia, Blusson Spinal Cord Centre, 6th Floor, 818 West 10th Avenue, Vancouver, BC V5Z 1M9, Canada
    Int J Oncol 38:5-12. 2011
    ..Improved clinical research methodology for this patient population is required...
  4. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
    ..The standard treatment for spinal cord compression caused by metastatic cancer is corticosteroids and radiotherapy. The role of surgery has not been established. We assessed the efficacy of direct decompressive surgery...
  5. pmc Total en bloc spondylectomy for spinal tumors: improvement of the technique and its associated basic background
    Katsuro Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    J Orthop Sci 11:3-12. 2006
  6. ncbi Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
    ..To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC)...
  7. ncbi Spinal metastases: the obvious, the occult, and the impostors
    D A Wong
    Department of Orthopedic Surgery, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 15:1-4. 1990
    ..Overall, metastases were found in 36% of patients dying from neoplastic disease. Although most metastases are obvious, occult lesions not visible radiographically occur. Collapsed vertebra may be impostors simulating metastatic disease...
  8. ncbi Impact of surgical intervention on quality of life in patients with spinal metastases
    Alexis Falicov
    Vancouver Spine Program, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 31:2849-56. 2006
    ..Prospective clinical study...
  9. ncbi Primary vertebral tumors: a review of epidemiologic, histological, and imaging findings, Part I: benign tumors
    Alexander E Ropper
    Department of Neurosurgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 69:1171-80. 2011
    ..In combination with part II of the review, which focuses on locally aggressive and malignant tumors, this article provides a comprehensive review of primary vertebral tumors...
  10. ncbi Total en bloc spondylectomy for spinal tumors: surgical techniques and related basic background
    Norio Kawahara
    Department of Orthopedic Surgery, Graduate School of Medical Science Kanazawa University, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Orthop Clin North Am 40:47-63, vi. 2009
    ..Review of the developmental process of this operation leads to recognition of the tips, pitfalls, and solutions...
  11. ncbi Reconstruction using an autograft containing tumour treated by liquid nitrogen
    H Tsuchiya
    Kanazawa University, Kanazawa, Japan
    J Bone Joint Surg Br 87:218-25. 2005
    ..All were managed successfully. Our results suggest that this is a simple and effective method of biological reconstruction...
  12. ncbi A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group
    Charles G Fisher
    Combined Neurosurgery and Orthopaedic Spine Program, Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada
    Spine (Phila Pa 1976) 35:E1221-9. 2010
    ..Systematic review and modified Delphi technique...
  13. pmc En bloc spondylectomy in malignant tumors of the spine
    Ulf Liljenqvist
    Department of Spine Surgery, St Franziskus Hospital Muenster, Hohenzollernring 72, 48145, Muenster, Germany
    Eur Spine J 17:600-9. 2008
    ..Intralesional resection, poor histologic response, and solitary spinal metastases of Ewing and osteosarcoma are associated with a poor prognosis...
  14. ncbi Chordoma
    Paolo G Casali
    Adult Sarcoma Medical Oncology Unit, Istituto Nazionale dei Tumori, Milano, Italy
    Curr Opin Oncol 19:367-70. 2007
    ..To review developments in chordoma treatment...
  15. ncbi Primary bone tumors of the spine. Terminology and surgical staging
    S Boriani
    Department of Orthopaedics and Traumatology, Ospedale Maggiore, Bologna, Italy
    Spine (Phila Pa 1976) 22:1036-44. 1997
    ..The principles of the Enneking system for classifying stages of tumors are emphasized and applied to the spine using a practical approach for surgical staging...
  16. ncbi Delayed radiation-induced myelopathy after spinal radiosurgery
    Iris C Gibbs
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Neurosurgery 64:A67-72. 2009
    ..We report a case series of 6 patients treated with radiosurgery who developed delayed myelopathy...
  17. ncbi Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases
    Arjun Sahgal
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 74:723-31. 2009
    ..To provide actuarial outcomes and dosimetric data for spinal/paraspinal metastases, with and without prior radiation, treated with stereotactic body radiotherapy (SBRT)...
  18. ncbi Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma
    Holger Hof
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Onkologie 29:572-4. 2006
    ..Chordomas are rare tumors of the skull base and the spine. Treatment is difficult since conventional radiotherapy or chemotherapy have only limited effects...
  19. ncbi A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis
    Yasuaki Tokuhashi
    Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Spine (Phila Pa 1976) 30:2186-91. 2005
    ..A semi-prospective clinical study was conducted...
  20. ncbi Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy
    Stefanie Milker-Zabel
    Department of Clinical Radiology, Radiation Therapy, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:162-7. 2003
    ..We evaluated local control, pain relief, neurologic improvement, side effects, and survival rates after fractionated conformal radiotherapy (FCRT) and intensity-modulated RT (IMRT) of recurrent spinal metastases...
  21. ncbi Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report
    XiaoFeng Lian
    Department of Orthopedics, Changhai Hospital, Shanghai, China
    Spine (Phila Pa 1976) 31:E895-9. 2006
    ..A case report of a rare benign osteoblastoma successfully treated with total en bloc excision...
  22. pmc Wide resection of sacral chordoma via a posterior approach
    Apichat Asavamongkolkul
    Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand
    Int Orthop 36:607-12. 2012
    ..The study was carried out to report the results of wide resection in sacral chordoma using a posterior approach and gauze packing technique...
  23. ncbi Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group
    Daryl R Fourney
    University of Saskatchewan, Royal University Hospital, 103 Hospital Dr, Saskatoon, Saskatchewan, Canada
    J Clin Oncol 29:3072-7. 2011
    ..The objective of this study was to determine the interobserver reliability, intraobserver reliability, and predictive validity of the Spinal Instability Neoplastic Score (SINS)...
  24. ncbi Final results of a prospective study comparing the local control of short-course and long-course radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:524-30. 2011
    ..This is the first prospective study that has compared local control of different radiotherapy schedules for MSCC...
  25. ncbi Lytic metastases in thoracolumbar spine: computer-aided detection at CT--preliminary study
    Jianhua Yao
    Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C351, 10 Center Dr, MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 242:811-6. 2007
    ..To evaluate the sensitivity of a computer-aided detection (CAD) system for detection of lytic thoracolumbar spinal lesions at body CT, with results of manual lesion segmentation as the reference standard...
  26. pmc Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases
    Stefano Boriani
    Department of Oncologic and Degenerative Spine Surgery, Rizzoli Institute, Bologna, Italy
    Eur Spine J 21:2003-10. 2012
    ..To define the role of Enneking staging system and of the consequent different treatment options on the outcome of osteoblastoma (OBL) of the spine...
  27. ncbi Lumbosacral chordoma. Prognostic factors and treatment
    E Y Cheng
    Department of Orthopaedic Surgery, University of Minnesota Cancer Center, Minneapolis, USA
    Spine (Phila Pa 1976) 24:1639-45. 1999
    ..Retrospective analysis...
  28. ncbi Efficacy evaluation of a new treatment algorithm for spinal metastases
    Alessandro Gasbarrini
    Department of Oncologic and Degenerative Spine Surgery, Rizzoli Institute, Bologna, Italy
    Spine (Phila Pa 1976) 35:1466-70. 2010
    ..A semiprospective clinical study was conducted...
  29. ncbi Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature
    Abbass Amirjamshidi
    Sina Hospital, Tehran University of Medical Sciences TUMS, Tehran, Iran
    Pediatr Neurosurg 46:396-401. 2010
    ..BACKGROUND/SUBJECT: A rare case of osteoblastoma of the third cervical vertebra (C3) occurring in a 16-year-old adolescent is presented. He was admitted suffering from neck pain for more than 3 years...
  30. ncbi Patterns of practice in palliative radiotherapy for painful bone metastases: a survey in Japan
    Naoki Nakamura
    Department of Radiation Oncology, St Luke s International Hospital, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 83:e117-20. 2012
    ..To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT)...
  31. ncbi Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003
    Debraj Mukherjee
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Neurosurg Spine 14:143-50. 2011
    Malignant primary osseous spinal neoplasms are aggressive tumors that remain associated with poor outcomes despite aggressive multidisciplinary treatment measures...
  32. ncbi Surgical management of unknown primary tumors metastatic to the spine
    Michele R Aizenberg
    Division of Neurosurgery, The University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Neurosurg Spine 16:86-92. 2012
    ..Patients presenting with spinal metastases from unknown primary tumors (UPTs) are rare. The authors reviewed their surgical experience to evaluate outcomes and identify predictors of survival in these patients...
  33. ncbi Analysis of prognostic factors for patients with chordoma with use of the California Cancer Registry
    Joe Lee
    Department of Orthopaedic Surgery, University of California, Irvine, Irvine, California, USA
    J Bone Joint Surg Am 94:356-63. 2012
    ..Using data from a large, population-based cancer registry, we designed the present study to examine the outcome for patients with chordoma and to determine relevant prognostic factors...
  34. ncbi Diagnosis and management of metastatic spine disease. A review
    Daniel M Sciubba
    Departments of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurosurg Spine 13:94-108. 2010
    ..Ultimately, the goal of treatment in patients with spinal metastases remains palliative, and clinical judgment is required to select the appropriate patients for surgical intervention...
  35. ncbi Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord
    Clara Y H Choi
    Department of Neurosurgery, Stanford University Medical Center, CA, USA
    Int J Radiat Oncol Biol Phys 78:499-506. 2010
    ..As the spinal cord tolerance often precludes reirradiation with conventional techniques, local recurrence within a previously irradiated field presents a treatment challenge...
  36. ncbi High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions
    Yoshiya Yamada
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 71:484-90. 2008
    ..To report tumor control and toxicity for patients treated with image-guided intensity-modulated radiotherapy (RT) for spinal metastases with high-dose single-fraction RT...
  37. ncbi Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group
    Toshifumi Ozaki
    Department of Orthopedic Surgery, Westfalische Wilhelms University, Munster, Germany
    Cancer 94:1069-77. 2002
    ..Due to the low incidence rate, the optimal strategy for the treatment of patients with spinal osteosarcoma is unknown...
  38. ncbi Reconstruction after extirpation of sacral malignancies
    Jose Diaz
    University of Miami School of Medicine, DeWitt Daughtry Department of Surgery, FL, USA
    Ann Plast Surg 51:126-9. 2003
    ..The authors' experience suggests that this combination of techniques is a reliable approach for reconstruction of these extensive surgical defects...
  39. ncbi Primary vertebral osteosarcoma: imaging findings
    Hakan Ilaslan
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Radiology 230:697-702. 2004
    ..To evaluate patient age and sex and location and imaging appearances of primary vertebral osteosarcoma (PVOS) compared with histologic subtypes...
  40. ncbi Scoring system for the preoperative evaluation of metastatic spine tumor prognosis
    Y Tokuhashi
    Department of Orthopaedic Surgery, Nihon University, School of Medicine, Tokyo
    Spine (Phila Pa 1976) 15:1110-3. 1990
    ..In conclusion, an excisional operation should be performed on those cases who scored above 9 points, while a palliative operation is indicated for those who scored under 5 points...
  41. ncbi Predictors of survival after surgical treatment of spinal metastasis
    Robert T Arrigo
    Stanford University School of Medicine, Department of Neurosurgery, Stanford University Medical Center, Palo Alto, California 94304, USA
    Neurosurgery 68:674-81; discussion 681. 2011
    ....
  42. ncbi The role of radiotherapy for metastatic epidural spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:590-8. 2010
    ..Larger prospective trials are required to better define the appropriate treatment for the individual patient...
  43. ncbi Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery
    Samuel Ryu
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Cancer 109:628-36. 2007
    ..The tolerance of partial volume of the spinal cord may determine the extent of clinical application. The study analyzed the partial volume tolerance of the human spinal cord to single fraction radiosurgery...
  44. ncbi Shifting paradigms in the treatment of metastatic spine disease
    Mark H Bilsky
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Spine (Phila Pa 1976) 34:S101-7. 2009
    ..Systematic review and evidence appraisal...
  45. ncbi Percutaneous vertebral augmentation in metastatic disease: state of the art
    Flavio Tancioni
    Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
    J Support Oncol 9:4-10. 2011
    ....
  46. ncbi Treatment of metastatic spinal tumors by percutaneous vertebroplasty versus percutaneous vertebroplasty combined with interstitial implantation of 125I seeds
    Zuozhang Yang
    Department of Orthopedics, Tumor Hospital of Yunnan Province, Third Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, P R China
    Acta Radiol 50:1142-8. 2009
    ..To avoid the trauma and complications of open surgery, a minimally invasive procedure, percutaneous vertebroplasty (PVP), has recently been developed to treat metastatic spinal tumors...
  47. ncbi Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients
    Richard G Perrin
    Division of Neurosurgery, Department of Surgery, University of Toronto, St Michael s Hospital, 55 Queen Street E Suite 948, Toronto, Ontario M5C 1R6, Canada
    Neurosurg Clin N Am 15:365-73. 2004
    ..Percutaneous image-guided biopsy is a useful test to establish a tissue diagnosis...
  48. ncbi Genome-wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1
    S Scheil
    Institute of Pathology, University Hospitals of Ulm, Ulm, Germany
    Genes Chromosomes Cancer 32:203-11. 2001
    ..Our data suggest that tumor suppressor genes or mismatch repair genes (located at 1p31 and 3p14) and oncogenes (located in 7q36) might be involved in chordoma genesis...
  49. ncbi Vertebral metastases: a critical appreciation of the preoperative prognostic tokuhashi score in a series of 71 cases
    E A Enkaoua
    , Paris, France
    Spine (Phila Pa 1976) 22:2293-8. 1997
    ..However, it attributes the same one-point rating to metastases of renal cancer and to those of unknown primary tumors. In the case of metastases of unknown primary tumors, this rating is too high and should be reduced to 0...
  50. ncbi Clinical trials and evidence-based medicine for metastatic spine disease
    Paul Klimo
    Department of Neurosurgery, University of Utah School of Medicine, 30 North 1900 East, Suite 3B 409 SOM, Salt Lake City, UT 84132 2303, USA
    Neurosurg Clin N Am 15:549-64. 2004
    ..The role of nonconventional radiation therapy, such as IMRT and SRS, remains to be elucidated...
  51. ncbi Minimally invasive resection of intradural-extramedullary spinal neoplasms
    Trent L Tredway
    Department of Neurosurgery, University of Washington, Seattle, Washington, USA
    Neurosurgery 58:ONS52-8; discussion ONS52-8. 2006
    ..Traditional treatment of these tumors includes open laminectomy with intradural resection. We describe an alternative minimally invasive surgical technique in a consecutive series of patients undergoing treatment for symptomatic lesions...
  52. ncbi CyberKnife stereotactic radiosurgical treatment of spinal tumors for pain control and quality of life
    Jeffrey W Degen
    Department of Neurosurgery, Georgetown University Hospital, Washington, DC 20007, USA
    J Neurosurg Spine 2:540-9. 2005
    ..The authors conducted a study to assess safety, pain, and quality of life (QOL) outcomes following CyberKnife radiosurgical treatment of spinal tumors...
  53. ncbi Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis
    Samuel Ryu
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Cancer 97:2013-8. 2003
    ..The authors studied spinal radiosurgery in patients with spinal metastases to determine its accuracy and precision...
  54. pmc Predictive value of seven preoperative prognostic scoring systems for spinal metastases
    Andreas Leithner
    University Clinic of Orthopaedic Surgery, Medical University of Graz, Graz, Austria
    Eur Spine J 17:1488-95. 2008
    ..However, decision for or against surgery should never be based alone on a prognostic score but should take symptoms like pain or neurological compromise into account...
  55. ncbi Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread
    Joseph H Schwab
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg Oncol 14:1507-14. 2007
    ..Anecdotal evidence, mainly supported by isolated case reports, suggests that a subset of these patients also develop bone metastasis, especially within the spine, which was previously under-appreciated...
  56. ncbi Efficacy of percutaneous vertebroplasty combined with radiotherapy in osteolytic metastatic spinal tumors
    Jee Soo Jang
    Wooridul Spinal Hospital, Seoul, South Korea
    J Neurosurg Spine 2:243-8. 2005
    ..The purpose of this study was to evaluate the merits and efficacy of percutaneous vertebroplasty (PVP) combined with radiotherapy in treating patients with osteolytic metastatic spinal tumors (OMSTs)...
  57. ncbi Pain control by image-guided radiosurgery for solitary spinal metastasis
    Samuel Ryu
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Pain Symptom Manage 35:292-8. 2008
    ..This experience demonstrates that spinal radiosurgery can achieve rapid and durable pain relief. Single-dose radiosurgery has a potential to be a viable treatment option for single spinal metastasis...
  58. pmc Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature
    Amer Samdani
    Shriners Hospital for Children, 3551 North Broad Street, Philadelphia, PA 19027, USA
    Eur Spine J 18:196-200. 2009
    ..This multidisciplinary approach markedly decreased blood loss and improved visualization to help achieve complete surgical resection and resolution of clinical symptoms...
  59. pmc Retroperitoneal transdiaphragmatic robotic-assisted laparoscopic resection of a left thoracolumbar neurofibroma
    Ross M Moskowitz
    Department of Urology, University of California, Irvine, Irvine, California, USA
    JSLS 13:64-8. 2009
    ..This report describes the first use of robotic technology to resect a left thoracolumbar neurofibroma...
  60. ncbi Robot-assisted thoracoscopic resection of a benign mediastinal neurogenic tumor: technical note
    Jelle P Ruurda
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurosurgery 52:462-4; discussion 464. 2003
    ..The first case report of robot-assisted thoracoscopic removal of a benign neurogenic tumor in the thorax is presented...
  61. ncbi Outcome of treatment for spinal metastases using scoring system for preoperative evaluation of prognosis
    Yasuaki Tokuhashi
    Department of Orthopaedic Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, Japan
    Spine (Phila Pa 1976) 34:69-73. 2009
    ..Prospective study...
  62. ncbi Both location and age predict survival in ependymoma: a SEER study
    Courtney S McGuire
    Department of Neurology, Stanford University, Palo Alto, California, USA
    Pediatr Blood Cancer 52:65-9. 2009
    ..Using a population-based registry of ependymomas, we analyzed how age, gender, location, race and radiotherapy influence survival in children...
  63. ncbi Surgical strategy for spinal metastases
    K Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Spine (Phila Pa 1976) 26:298-306. 2001
    ..3 months. CONCLUSIONS: A new surgical strategy for spinal metastases based on the prognostic scoring system is proposed. This strategy provides appropriate guidelines for treatment in all patients with spinal metastases...
  64. ncbi Prognostic factors and a scoring system for survival after radiotherapy for metastases to the spinal column: a review of 544 patients at Shizuoka Cancer Center Hospital
    Masashi Mizumoto
    Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan
    Cancer 113:2816-22. 2008
    ..To optimize selection of a radiotherapy schedule for patients with spinal metastases, the authors analyzed prognostic factors and developed a scoring system to predict survival in such patients...
  65. ncbi Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases
    Anand Mahadevan
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Int J Radiat Oncol Biol Phys 81:1500-5. 2011
    ..We report the use of SBRT for 60 consecutive patients (81 lesions) who had radiological progressive spine metastasis with epidural involvement after previous radiation for spine metastasis...
  66. ncbi The first score predicting overall survival in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 112:157-61. 2008
    ..The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC)...
  67. ncbi Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group
    D Andrew Loblaw
    Departments of Radiation Oncology and Medicine, Sunnybrook and Women s College Health Science Centre, University of Toronto, Ontario, Canada
    J Clin Oncol 23:2028-37. 2005
    ..This systematic review describes the diagnosis and management of adult patients with a suspected or confirmed diagnosis of extradural malignant spinal cord compression (MSCC)...
  68. ncbi Radical excision of malignant sacral tumors using a modified threadwire saw
    Shunzo Osaka
    Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Surg Oncol 93:312-7. 2006
    ..Surgical treatment of malignant sacral tumors is difficult, and has a high rate of recurrence...
  69. ncbi Use of radio-frequency ablation for the palliative treatment of sacral chordoma
    Nassar Anis
    Department of Radiology, Lebanese Hospital, Geitawi, Beirut, Lebanon
    AJNR Am J Neuroradiol 25:1589-91. 2004
    ..We report its use in the palliative treatment of chordomas in two patients for debulking and control of pain, with good results and low morbidity...
  70. ncbi Management of metastatic tumors of the spine: strategies and operative indications
    M P Steinmetz
    Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Neurosurg Focus 11:e2. 2001
    ..Treatment strategies, both operative and nonoperative, are presented. Indications and strategies for surgery are also presented, and the supporting literature is reviewed...
  71. ncbi Spine metastases: current treatments and future directions
    Ran Harel
    Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, S 80, Cleveland, OH 44195, USA
    Eur J Cancer 46:2696-707. 2010
    ..It outlines a multidisciplinary and integrated approach to these patients and it is hoped that this along with future advances and research will result in improved patient care and outcomes...
  72. ncbi Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors
    Takehiko Yamaguchi
    Department of Pathology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami Koshigaya, Koshigaya, Saitama, Japan
    Mod Pathol 18:1005-10. 2005
    ..We suspect that unknown factors transform incipient chordoma into classic chordoma...
  73. ncbi Cyberknife radiosurgery for breast cancer spine metastases: a matched-pair analysis
    Gregory J Gagnon
    Department of Radiation Oncology, Georgetown University Medical Center, Washington, DC 20007 2113, USA
    Cancer 110:1796-802. 2007
    ....
  74. ncbi A cemented caval vein filter: case report
    Frank Herbstreit
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Spine (Phila Pa 1976) 31:E917-9. 2006
    ..Case report...
  75. ncbi Surgical management of prostate cancer metastatic to the spine
    Brian J Williams
    Department of Neurosurgery, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Neurosurg Spine 10:414-22. 2009
    ..In this study, a series of patients undergoing spinal surgery for metastatic prostate cancer were reviewed to identify predictors of survival and functional outcome...
  76. ncbi DEGRO practice guidelines for palliative radiotherapy of metastatic breast cancer: bone metastases and metastatic spinal cord compression (MSCC)
    Rainer Souchon
    Department of Radiation Oncology, UKT Tübingen, Tubingen, Germany
    Strahlenther Onkol 185:417-24. 2009
    ..To provide practice guidelines and clinical recommendations on preferred standard palliative radiation therapy of bone metastases as well as metastatic spinal cord compression (MSCC) for metastatic breast cancer patients...
  77. ncbi Endovascular embolization of cervical hemangiopericytoma with Onyx-18: case report and review of the literature
    Alejandro Santillan
    Division of Interventional Neuroradiology, Department of Neurological Surgery, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10065, USA
    J Neurointerv Surg 3:304-7. 2011
    ..Preoperative embolization with Onyx-18 should be considered for large HPC as it may decrease the risk of intraoperative hemorrhage. In this case, embolization with Onyx-18 did not preclude histopathologic diagnosis of HPC...
  78. pmc Surgical margins and local control in resection of sacral chordomas
    Pietro Ruggieri
    Department of Orthopedics, University of Bologna, Istituto Ortopedico Rizzoli, Via Pupilli, 1, 40136, Bologna BO, Italy
    Clin Orthop Relat Res 468:2939-47. 2010
    ..The quality of surgical margins obtained at initial surgery is the primary factor to improve survival reducing the risk of local recurrence, but proximal sacral resections are associated with substantial perioperative morbidity...
  79. ncbi Cyberknife radiosurgery for metastatic spine tumors
    Peter C Gerszten
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neurosurg Clin N Am 15:491-501. 2004
    ..Spinal radiosurgery is likely to become an essential part of any neurosurgical spine center that treats a large number of patients with spinal metastases...
  80. ncbi Cryoablation of recurrent sacrococcygeal tumors
    Anil Nicholas Kurup
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Vasc Interv Radiol 23:1070-5. 2012
    ..To review the safety and efficacy of cryoablation of recurrent sacrococcygeal tumors...
  81. ncbi Metastatic patterns of extremity myxoid liposarcoma and their outcome
    Susanne H Estourgie
    School of Medicine, University of Utrecht, Utrecht, The Netherlands
    J Surg Oncol 80:89-93. 2002
    ..Extremity myxoid liposarcomas have a unique extrapulmonary metastatic potential. We studied the metastatic pattern of extremity liposarcomas to determine what types of posttreatment imaging may be of value in the follow-up these patients...
  82. ncbi International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery
    Brett W Cox
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Int J Radiat Oncol Biol Phys 83:e597-605. 2012
    ..However, target volume definition varies considerably and no consensus target volume guidelines exist. This study proposes consensus target volume definitions using common scenarios in metastatic spine radiosurgery...
  83. ncbi Total spondylectomy for primary malignant, aggressive benign, and solitary metastatic bone tumors of the thoracolumbar spine
    E Abe
    Department of Orthopedic Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Spinal Disord 14:237-46. 2001
    ..These results suggest that this type of total spondylectomy is effective in controlling local recurrence without incurring major complications and is a clinically useful procedure...
  84. ncbi Association of extent of local tumor invasion and survival in patients with malignant primary osseous spinal neoplasms from the surveillance, epidemiology, and end results (SEER) database
    Debraj Mukherjee
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 76:580-5. 2011
    Malignant osseous spinal neoplasms are aggressive tumors associated with poor outcomes despite aggressive multidisciplinary measures. It remains unknown whether increased local tumor invasion at time of treatment predicts worse survival...
  85. ncbi A human cadaver model for determination of pathologic fracture threshold resulting from tumorous destruction of the vertebral body
    J R Dimar
    Department of Orthopaedic Surgery, University of Louisville School of Medicine, Kentucky, USA
    Spine (Phila Pa 1976) 23:1209-14. 1998
    ....
  86. ncbi Osteoblastoma
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 134:1460-6. 2010
    ....
  87. ncbi Desmoid tumor of the spinal canal causing scoliosis and paralysis
    Michael K Shindle
    Department of Orthopaedic Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 27:E304-7. 2002
    ..This report describes a case of successful surgical excision of an intrathoracic paraspinal desmoid tumor with an intraspinous extension causing scoliosis and paralysis in a 12-year-old girl...
  88. ncbi Radiosurgery for benign tumors of the spine using the Synergy S with cone-beam computed tomography image guidance
    Peter C Gerszten
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Neurosurg 117:197-202. 2012
    ..This study represents an evaluation of, and reporting on, the technical aspects of using a dedicated radiosurgery system for the treatment of benign spine tumors...
  89. ncbi Reirradiation human spinal cord tolerance for stereotactic body radiotherapy
    Arjun Sahgal
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:107-16. 2012
    ....
  90. pmc Survival, complications and outcome in 282 patients operated for neurological deficit due to thoracic or lumbar spinal metastases
    Karl Ake Jansson
    Oncology Service, Department of Orthopedics, Karolinska Hospital, 171 76 Stockholm, Sweden
    Eur Spine J 15:196-202. 2006
    ..This study shows that important improvement of function can be gained by surgical treatment, but the complication rate was high and many patients died of their disease within the first months of surgery...
  91. ncbi Selecting treatment for patients with malignant epidural spinal cord compression-does age matter?: results from a randomized clinical trial
    John H Chi
    Department of Neurological Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Spine (Phila Pa 1976) 34:431-5. 2009
    ..Randomized clinical trial. OBJECTIVE.: To determine if age affects outcomes from differing treatments in patients with spinal metastases...
  92. ncbi Spinal cord sparing reirradiation with helical tomotherapy
    Florian Sterzing
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 116:3961-8. 2010
    ..The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord-sparing reirradiation of spinal metastases and tumors...
  93. pmc The treatment of spinal metastases
    Karl Stefan Delank
    Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitat Koln, Koln, Germany
    Dtsch Arztebl Int 108:71-9; quiz 80. 2011
    ..The main factors to be considered are the histology of the primary tumor, potential spinal instability, and compression of neural structures...
  94. ncbi Preoperative grading scale to predict survival in patients undergoing resection of malignant primary osseous spinal neoplasms
    Matthew J McGirt
    Department of Neurological Surgery, Vanderbilt University Medical Center, 4340 The Village at Vanderbilt, Nashville, TN 37232 8618, USA
    Spine J 11:190-6. 2011
    Large population-based studies of malignant primary osseous spinal neoplasms are lacking and are necessary to have sufficient statistical power to determine if various patient-related factors are in fact significant indicators of prognosis...
  95. ncbi Local tumor control after retreatment of spinal metastasis using stereotactic body radiotherapy; comparison with initial treatment group
    Ung Kyu Chang
    Department of Neurosurgery, Korean Cancer Center Hospital, Korea Institute of Radiological and Medical Science
    Acta Oncol 51:589-95. 2012
    ..The aim of this study is to evaluate local control rates after stereotactic body radiotherapy (SBRT) in recurrent spinal metastasis after external beam radiotherapy (EBRT) and new spinal metastatic lesions...
  96. ncbi Widespread metastases from acinic cell carcinoma of parotid gland
    S Vidyadhara
    Department of Spine Surgery, Ganga Hospital, Swarnambika Layout Ramnagar, Coimbatore 641009, Tamil Nadu, India
    Singapore Med J 48:e13-5. 2007
    ..This case report stresses the need for postoperative radiotherapy following incomplete resection of the primary tumour. A careful watch for distant metastasis is also of paramount importance at follow-up...
  97. pmc Management of metastatic sacral tumours
    Nasir A Quraishi
    Centre for Spinal Studies and Surgery, Queen s Medical Centre Campus of Nottingham University Hospitals, Derby Road, Nottingham, UK
    Eur Spine J 21:1984-93. 2012
    ..This study aims to review the available literature in the management of sacral metastatic tumours as reflected in the current literature...
  98. ncbi Distant bone metastases from carcinoma of the lip: a report of four cases
    K Vahtsevanos
    Department of Maxillofacial Surgical Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece
    Int J Oral Maxillofac Surg 36:180-5. 2007
    ..Distant metastases from labial carcinoma are rare, not exceeding 2%. Metastasis to bone and axillary lymph nodes is exceptionally rare and can be attributed to either inadequate initial management or aggressive tumour behaviour...
  99. ncbi Spinal instability and deformity due to neoplastic conditions
    Daryl R Fourney
    Division of Neurosurgery, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Neurosurg Focus 14:e8. 2003
    ..The authors discuss the most common patterns of tumor-related instability and deformity at all levels of the spinal column and review the surgical options for treatment...
  100. ncbi Spinal metastasis from a primary parotid carcinoma: a case report
    Abraham Manoj-Thomas
    Joint Bone Spine 73:573-5. 2006
  101. ncbi Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients
    Michelle J Clarke
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
    Neurosurgery 71:357-64; discussion 364. 2012
    ..However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is possible from a posterior-only approach in many cases...

Research Grants13

  1. APOPTOSIS--ROLE OF HSP72 AND NOVEL DEATH ANTAGONISTS
    Robin Anderson; Fiscal Year: 2001
    ..The results of these studies should provide the knowledge required for the development of therapeutic strategies for tumours that develop resistance to apoptosis. ..
  2. Genes important in breast cancer metastasis
    Robin Anderson; Fiscal Year: 2003
    ..These studies will provide a significant advance in the search for new targets for therapeutic intervention and better diagnostic markers of metastasis. ..
  3. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..This has also been the basis for successful application and granting of Orphan-Drug designation for cytarabine (Ara-C) liposome injection (trade name: DepoCyt) for the treatment of gliomas. ..
  4. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  5. Antigen specific modeling of glioma immunotherapy
    Andrew Parsa; Fiscal Year: 2007
    ..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..
  6. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Polysomal RNA Antitumor Immunity
    John Chi; Fiscal Year: 2005
    ..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
  8. CLINICAL RESEARCH IN NEURO-ONCOLOGY
    ROY PATCHELL; Fiscal Year: 2004
    ..abstract_text> ..
  9. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  10. RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASES
    AMIN KASSIS; Fiscal Year: 2004
    ....
  11. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  12. RAPID MR VS XRAY: RANDOMIZED OUTCOME TRIAL FOR BACK PAIN
    JEFFREY JARVIK; Fiscal Year: 2001
    ..We have a window of opportunity before the rapid MRI becomes widely disseminated and a randomized trial is made impossible by the expectations of both patients and physicians. ..
  13. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ....