experimental liver neoplasms

Summary

Summary: Experimentally induced tumors of the LIVER.

Top Publications

  1. ncbi Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans
    T Kishimoto
    Department of Biology, Faculty of Science, Chiba University, Japan
    Cell Growth Differ 9:337-44. 1998
  2. ncbi Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, Japan
    J Membr Biol 218:101-6. 2007
  3. ncbi Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
  4. ncbi Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    Jean Francois H Geschwind
    Division of Cardiovascular and Interventional Radiology, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cancer Res 62:3909-13. 2002
  5. ncbi Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Cancer Lett 173:83-91. 2001
  6. ncbi Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    Fan Yang
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Res 67:863-7. 2007
  7. ncbi Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo
    Jin Seok Kang
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Cancer Res 67:11141-6. 2007
  8. ncbi IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
    Cell 121:977-90. 2005
  9. pmc Distinct pathways of genomic progression to benign and malignant tumors of the liver
    Aaron D Tward
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:14771-6. 2007
  10. ncbi Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    Willscott E Naugler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
    Science 317:121-4. 2007

Research Grants

  1. Polyamine Suppression By Antizyme inducing Analogs
    John Mitchell; Fiscal Year: 2002
  2. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
  3. Prevention of Cigarette Smoke-Induced Lung Cancer by Dietary Selenium
    HOWARD GLAUERT; Fiscal Year: 2008
  4. STEM CELLS AND HEPATOCARCINOGENESIS
    Stewart Sell; Fiscal Year: 2009
  5. Dietary Antioxidants, NF-KappaBeta, and Carcinogenesis
    HOWARD GLAUERT; Fiscal Year: 2002
  6. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
  7. AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICE
    Stewart Sell; Fiscal Year: 2002
  8. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2010
  9. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2008
  10. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004

Detail Information

Publications207 found, 100 shown here

  1. ncbi Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans
    T Kishimoto
    Department of Biology, Faculty of Science, Chiba University, Japan
    Cell Growth Differ 9:337-44. 1998
    ..Injection of anti-HTF antibody decreased the growth rate of cultured HCC cells. Consequently, HTF is thought to participate in hepatocyte growth as well as in hepatocarcinogenesis...
  2. ncbi Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, Japan
    J Membr Biol 218:101-6. 2007
    ..Thus, normal function of Cx32 may be essential for suppression of both early and late stages of hepatocarcinogenesis...
  3. ncbi Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  4. ncbi Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    Jean Francois H Geschwind
    Division of Cardiovascular and Interventional Radiology, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cancer Res 62:3909-13. 2002
    ....
  5. ncbi Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
    Y H Ko
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA
    Cancer Lett 173:83-91. 2001
    ..Finally, when tested on hepatoma cells in culture both inhibitors facilitated cell death. These studies underscore the usefulness of the VX2 tumor model for the study of advanced liver cancer and for selecting anti-hepatoma agents...
  6. ncbi Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    Fan Yang
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Res 67:863-7. 2007
    ..Our results suggest an intriguing link between metabolic regulation and hepatocarcinogenesis...
  7. ncbi Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo
    Jin Seok Kang
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Cancer Res 67:11141-6. 2007
    ..It is suggested that CYP2E1 completely participates in diethylnitrosamine-induced hepatocarcinogenesis, and high frequency of tumors in wild-type mice could be associated with the increased apoptosis...
  8. ncbi IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
    Cell 121:977-90. 2005
    ..IKKbeta, therefore, orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis...
  9. pmc Distinct pathways of genomic progression to benign and malignant tumors of the liver
    Aaron D Tward
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:14771-6. 2007
    ....
  10. ncbi Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    Willscott E Naugler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
    Science 317:121-4. 2007
    ..We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...
  11. pmc Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor
    Vladimir V Kalinichenko
    University of Illinois at Chicago, College of Medicine, Department of Biochemistry and Molecular Genetics, Chicago, Illinois 60607, USA
    Genes Dev 18:830-50. 2004
    ..Our studies demonstrate that the Foxm1b transcription factor is required for proliferative expansion during tumor progression and constitutes a potential new target for therapy of human HCC tumors...
  12. ncbi Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice
    Arlin B Rogers
    Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:668-77. 2004
    ..Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma...
  13. ncbi Demonstration of direct lineage between hepatocytes and hepatocellular carcinoma in diethylnitrosamine-treated rats
    Marie Pierre Bralet
    Departement de Pathologie, Hopital Henri Mondor, AP HP, Créteil and Laboratoire de Thérapie Génique, INSERM ERM 01 05, Centre Hospitalier Universitaire de Nantes, Nantes, France
    Hepatology 36:623-30. 2002
    ..This figure precisely matched the proportion of labeled hepatocytes before DEN treatment (18.3%). In conclusion, a random clonal origin of HCC from mature hepatocytes is seen in the DEN model of hepatocarcinogenesis...
  14. ncbi Promotion by Helicobacter hepaticus-induced hepatitis of hepatic tumors initiated by N-nitrosodimethylamine in male A/JCr mice
    B A Diwan
    Intramural Research Support Program, SAIC Frederick, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Toxicol Pathol 25:597-605. 1997
    ..Thus, chronic H. hepaticus infection significantly stimulated cyclin D expression, accelerated the development of liver tumors, increased the multiplicity of such lesions, and enhanced the progression of benign to malignant tumors...
  15. ncbi Different responses other than the formation of DNA-adducts between the livers of carcinogen-resistant rats (DRH) and carcinogen-sensitive rats (Donryu) to 3'-methyl-4-dimethylaminoazobenzene administration
    Y Yan
    Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health, Fukuoka
    Jpn J Cancer Res 89:806-13. 1998
    ..These results indicate that the different susceptibility to hepatocarcinogenesis between these two strains of rats may arise from events other than the DNA adduct formation...
  16. ncbi Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    Herve Lerat
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    Gastroenterology 122:352-65. 2002
    ..The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation...
  17. ncbi Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
    H Murakami
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892
    Cancer Res 53:1719-23. 1993
    ....
  18. ncbi Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer
    Diego F Calvisi
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Pathol 33:181-4. 2005
    ....
  19. ncbi Telomerase-dependent oncolytic adenovirus for cancer treatment
    T G Huang
    Carl C Icahn Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Gene Ther 10:1241-7. 2003
    ..The results indicate that the TERT promoter-driven CRAD is capable of tumor-selective replication and oncolysis in vitro and in vivo, and can be utilized as an adjuvant treatment agent for cancer...
  20. pmc OncoDB.HCC: an integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci
    Wen Hui Su
    Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taipei 114, Taiwan
    Nucleic Acids Res 35:D727-31. 2007
    ..HCC graphically presents comprehensive HCC data integration, reveals important HCC genes and loci for positional cloning and functional studies, and discloses potential molecular targets for improving HCC diagnosis and therapy...
  21. pmc Experimental models of hepatocellular carcinoma
    Philippa Newell
    Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Hepatol 48:858-79. 2008
    ..These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies...
  22. pmc Experimental mouse models for hepatocellular carcinoma research
    Femke Heindryckx
    Department of Gastroenterology and Hepatology, Ghent University Hospital, 9000 Ghent, Belgium
    Int J Exp Pathol 90:367-86. 2009
    ..Transgenic mice expressing viral genes, oncogenes and/or growth factors allow the identification of pathways involved in hepatocarcinogenesis...
  23. ncbi Analyses of oxidative DNA damage and its repair activity in the livers of 3'-methyl-4-dimethylaminoazobenzene-treated rodents
    T Hirano
    Department of 1 Environmental Oncology, University of Occupational and Environmental Health, Japan
    Jpn J Cancer Res 91:681-5. 2000
    ..6-fold and 1.6-fold, respectively. These experiments suggest that 3'-MeDAB increases 8-OH-Gua generation in rodent liver DNA and the 8-OH-Gua repair assay is a reliable marker of cellular oxidative stress induced by carcinogens...
  24. ncbi Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration
    S Kishimoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan
    Biol Pharm Bull 23:344-8. 2000
    ..2 mg for SM-11355/Lipiodol and 0.1 mg for CDDP/Lipiodol, respectively. The results demonstrated that SM-11355/Lipiodol exerted antitumor activity at a dose that showed no hepatic toxicity in the rat model, but CDDP/Lipiodol did not...
  25. pmc Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma
    S Sell
    University of Texas Health Science Center, Department of Pathology and Laboratory Medicine, Houston 77225
    Am J Pathol 134:1347-63. 1989
    ..It is possible, however, that there may be more than one cellular lineage to hepatocellular cancer and that persistent nodules contain these different lineages...
  26. ncbi Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha
    E Santoni-Rugiu
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Cancer Res 58:123-34. 1998
    ..The data suggest that coexpression of c-myc and TGF-alpha leads to a selective growth advantage for hepatic (pre)neoplastic cells by disrupting the pRb/E2F pathway and by TGF-alpha-mediated reduction of apoptosis...
  27. ncbi Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease
    Andre Lechel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Germany
    Gastroenterology 132:1465-75. 2007
    ..The function of telomerase during in vivo hepatocarcinogenesis has not been studied in this genetic context...
  28. ncbi Transcatheter arterial chemoembolization with paclitaxel-lipiodol solution in rabbit VX2 liver tumor
    Chang Jin Yoon
    Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Radiology 229:126-31. 2003
    ....
  29. ncbi Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases
    Ajay Jain
    Department of Surgery, Division of Immunology and Hematapoiesis, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Surg Oncol 10:810-20. 2003
    ..Granulocyte-macrophage colony-stimulating factor-transduced tumor cell vaccines are less effective against cancer as the interval between metastasis and the initial vaccination increases...
  30. ncbi Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes
    Jennie L Walgren
    Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 171 Ashley Avenue, P O Box 250505, Charleston, SC 29425, USA
    Toxicology 211:220-30. 2005
    ..Nevertheless, the synergistic enhancement of epidermal growth factor-induced hepatocyte replication by DCA is of particular interest and warrants further study...
  31. ncbi Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice
    Mark Katzenellenbogen
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Cancer Res 66:4001-10. 2006
    ....
  32. ncbi Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis
    Yoshitaka Kamegaya
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Hepatology 41:660-7. 2005
    ..The accelerated tumor phenotype is attributable to suppression of apoptosis rather than enhanced proliferation. These data implicate HCV E1 and/or E2 in conjunction with core as antiapoptotic, tumor accelerator proteins...
  33. ncbi The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology and Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research TrianglePark, NC, USA
    Cancer Res 64:7197-200. 2004
    ..The results indicate that CAR is the molecular target of promotion by PB and that activation of this receptor is an essential requirement for liver tumor development...
  34. ncbi Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis
    Taro Takami
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4262, USA
    Cancer Res 67:9844-51. 2007
    ..These results argue that intact HGF/c-Met signaling is essential for maintaining normal redox homeostasis in the liver and has tumor suppressor effect(s) during the early stages of N-nitrosodiethylamine-induced hepatocarcinogenesis...
  35. pmc Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    Lars Zender
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 125:1253-67. 2006
    ..Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes...
  36. ncbi Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
    Toxicology 219:41-52. 2006
    ..The aim of this study was to determine if generation of reactive oxygen species and the resulting oxidative damage induced by free hepatic iron is directly hepatocarcinogenic...
  37. ncbi Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development
    Kojiro Matsumoto
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
    J Biol Chem 282:17053-60. 2007
    ..These studies provide direct evidence in support of a critical role of PBP/TRAP220 in liver regeneration, induction of hepatotoxicity, and hepatocarcinogenesis...
  38. ncbi Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer
    Diego F Calvisi
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 37, Room 4146A, 37 Convent Drive MSC 4262, Bethesda, MD 20892 4262, USA
    J Hepatol 42:842-9. 2005
    ..Here, we investigated the mechanisms responsible for nuclear translocation of wild-type beta-catenin and addressed the potential contribution of the Wnt pathway in c-Myc/E2F1 hepatocarcinogenesis...
  39. ncbi Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer
    Mustafa Vali
    Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Vasc Interv Radiol 18:95-101. 2007
    ..The authors performed a stepwise study in rabbits to determine the therapeutic dose and method of delivery of 3-BrPA...
  40. ncbi Mouse models to study the interaction of risk factors for human liver cancer
    Stewart Sell
    Ordway Research Institute and Wadsworth Center, Rpoom C 400, Empire State Plaza, Albany, NY 12201, USA
    Cancer Res 63:7553-62. 2003
    ..Future studies will explore the effects of modifying factors on the development of HCC...
  41. ncbi Combination of interferon-beta and the angiotensin-converting enzyme inhibitor, perindopril, attenuates murine hepatocellular carcinoma development and angiogenesis
    Ryuichi Noguchi
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 9:6038-45. 2003
    ....
  42. ncbi Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    I Issemann
    Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, UK
    Nature 347:645-50. 1990
    ..Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man...
  43. ncbi Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis
    J M Peters
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 21:823-6. 2000
    ..These data are consistent with the hypothesis that parenchymal cells respond to Kupffer cell-derived TNFalpha via mechanisms dependent on PPARalpha within the parenchymal cells...
  44. ncbi Hepatic intra-arterial injection of 3-bromopyruvate in rabbit VX2 tumor
    S W Shin
    Department of Radiology, Kangwon National University College of Medicine, Kangwon Do, Korea
    Acta Radiol 47:1036-41. 2006
    ..To evaluate the antitumoral effects of an intra-arterial injection of 3-bromopyruvate (3-BrPA) on liver VX2 tumor in rabbits...
  45. ncbi Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis
    E A Conner
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:5054-62. 2000
    ..In conclusion, E2F-1 overexpression in the liver causes dysplasia and tumors and suggests a cooperation between E2F-1 and c-myc oncogenes during liver oncogenesis...
  46. ncbi Cytotoxicity of cis-[((1R,2R)-1,2-cyclohexanediamine-N,N')bis(myristato)]-platinum (II) suspended in Lipiodol in a newly established cisplatin-resistant rat hepatoma cell line
    S Kishimoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Arise Igawadani cho, Nishi ku, Kobe 651 2180, Japan
    Jpn J Cancer Res 91:1326-32. 2000
    ..These results suggest that acquired CDDP resistance in H4-II-E / CDDP does not influence the cytotoxic activity of SM-11355 / Lipiodol...
  47. pmc Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis
    Shelly Beer
    Department of Medicine, Division of Oncology, School of Medicine, Center for Clinical Sciences Research, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e2493. 2008
    ....
  48. ncbi Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883
    P I Eacho
    Toxicology Division, Eli Lilly Company, Greenfield, IN 46140
    Carcinogenesis 12:1557-61. 1991
    ..Although sustained replication in the general population of hepatocytes may be involved in the carcinogenesis of WY-14,643, it does not appear to be a factor in the hepatocarcinogenesis of the other peroxisome proliferators...
  49. ncbi Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice
    Kayoko Takashima
    Department of Preventive Medicine, Shinshu University Graduate School of Medicine, Japan
    J Occup Health 50:169-80. 2008
    ..In contrast, the expression level of Met was notably increased in the liver adenoma tissue of wild-type mice, which may suggest the involvement of Met in DEHP-induced tumorigenesis in wild-type mice...
  50. ncbi The effects of dietary iron overload on fumonisin B1-induced cancer promotion in the rat liver
    E R Lemmer
    MRC UCT Liver Research Centre, University of Cape Town, South Africa
    Cancer Lett 146:207-15. 1999
    ....
  51. ncbi Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease
    N Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle 98195 7470, USA
    Semin Liver Dis 19:243-52. 1999
    ..This knowledge should be directly applicable to studies of human liver tumorigenesis...
  52. ncbi Evaluation of liver cell proliferation during ciprofibrate-induced hepatocarcinogenesis
    A V Yeldandi
    Department of Pathology, Northwestern University Medical School, Chicago, IL 60611
    Cancer Lett 47:21-7. 1989
    ..1984) Cancer Res., 44, 1072-1076). The results of this study further suggest that cell proliferation induced by peroxisome proliferators may be less important in carcinogenesis than peroxisome proliferation induced by these compounds...
  53. pmc Comparison of the hepatic effects of nafenopin and WY-14,643 on peroxisome proliferation and cell replication in the rat and Syrian hamster
    B G Lake
    BIBRA Toxicology International, Carshalton, Surrey, UK
    Environ Health Perspect 101:241-7. 1993
    ....
  54. ncbi Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital
    S Tamano
    Veterinary and Tumor Pathology Section, Office of Laboratory Animal Science, National Cancer Institute, Frederick, MD 21702 1201
    Carcinogenesis 15:1791-8. 1994
    ....
  55. ncbi Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice
    S Sanders
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Mol Carcinog 28:168-73. 2000
    ..However, these pathways appear to converge downstream, having common effectors in the form of bcl-2 family proteins. Mol. Carcinog. 28:168-173, 2000...
  56. pmc Antitumoral efficacy and pharmacokinetic properties of pirarubicin upon hepatic intra-arterial injection in the rabbit V x 2 tumour model
    M Okada
    Research Laboratories, Nippon Kayaku Co Ltd, Tokyo, Japan
    Br J Cancer 71:518-24. 1995
    ..injection of EPL. Our findings indicate that THP is the better candidate of the two drugs tested for the h.i.a. chemotherapy because of its greater anti-tumour activity and the lower systemic drug exposure achieved upon h.i.a. injection...
  57. ncbi Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase
    S P Mathupala
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 270:16918-25. 1995
    ....
  58. pmc Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption
    E Santoni-Rugiu
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Am J Pathol 154:1693-700. 1999
    ....
  59. pmc Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study
    Mustafa Vali
    Russell H Morgan Department of Radiology and Radiological Sciences, Division of Vascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Pharmacol Exp Ther 327:32-7. 2008
    ..The local control of the liver tumor by 3-BrPA resulted in a significant survival benefit...
  60. pmc Photodynamic therapy using intravenous delta-aminolaevulinic acid-induced protoporphyrin IX sensitisation in experimental hepatic tumours in rats
    K Svanberg
    Department of Oncology, Lund University Hospital, Sweden
    Br J Cancer 74:1526-33. 1996
    ..The tumour growth rate showed a marked decrease when evaluated 3 and 6 days after the treatment. These results show that the ALA-PDT is effective in the inhibition of growth of experimental hepatic tumours...
  61. ncbi Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase
    Rosa A Canuto
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Torino, Italy
    J Lipid Res 44:56-64. 2003
    ..In conclusion, inhibition of HMGR and decreased cholesterol content are crucial events in clofibrate-induced apoptosis in AH-130 hepatoma cells...
  62. pmc FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model
    Hee Sun Park
    Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Korean J Radiol 8:216-24. 2007
    ..We wanted to investigate the feasibility of using FDG-PET for evaluating the antitumor effect of intraarterial administration of a hexokinase II inhibitor, 3-bromopyruvate (3-BrPA), in a rabbit VX2 liver tumor model...
  63. ncbi Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643
    Howard P Glauert
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    Toxicol Sci 90:331-6. 2006
    ....
  64. ncbi Iron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron
    George A Asare
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand and Johannesburg Academic and Baragwanath Hospitals, South Africa
    J Pathol 208:82-90. 2006
    ....
  65. ncbi On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice
    F Caballero
    Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP) (CONICET-FCEN, UBA, Ciudad Universitaria, , 2do piso, 1428, Buenos Aires, Argentina
    Int J Biochem Cell Biol 33:681-90. 2001
    ..This study reports that long-term treatment with TMX enhances hepatocarcinogenesis induced by DAB. The widespread use of TMX as an anticancer agent adds to the significance of this study...
  66. ncbi Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors
    Lars Zender
    Department of Gastroenterology and Hepatology, Medical School Hannover, Hannover, Germany
    Gastroenterology 123:608-18. 2002
    ..The aim of this study was to evaluate the efficacy of p53/VP22 fusion protein in gene therapy of liver tumors...
  67. ncbi Percutaneous ablation of VX2 carcinoma-induced liver tumors with use of ethanol versus acetic acid: pilot study in a rabbit model
    Samir S Shah
    Section of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, 1 Silverstein, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    J Vasc Interv Radiol 15:63-7. 2004
    ..Early tissue changes were compared after injection of acetic acid and ethanol in a rabbit model of hepatocellular carcinoma...
  68. ncbi Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
    J Cancer Res Clin Oncol 134:753-9. 2008
    ..The current study sought to determine the effect of GDF-15 ablation on the development of hepatocellular carcinoma (HCC) in vivo...
  69. ncbi Promotion of hepatocarcinogenesis in humans and animal models
    Christoph Kohle
    Department of Toxicology, Institute of Pharmacology and Toxicology, University of Tubingen, Tubingen, Germany
    Arch Toxicol 82:623-31. 2008
    ..Further studies on the different modes of action may help to avoid overestimation of the risk of liver tumor promotion...
  70. ncbi Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice
    Niklas Finnberg
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Cancer Lett 207:149-55. 2004
    ..Furthermore, our findings suggest that the presence of only one functional p53 allele in p53+/- mice is sufficient to counteract the growth advantage that such an attenuated p53 response appears to confer...
  71. pmc Interstitial photodynamic therapy with the second-generation photosensitizer bacteriochlorin a in a rat model for liver metastases
    J P Rovers
    Department of Surgery, Leiden University Medical Centre, The Netherlands
    Br J Cancer 77:2098-103. 1998
    ..In view of the obtained lesion diameters of approximately 13 mm after BCA-PDT and the rapid clearance rate of BCA, the concept of a near-infrared absorbing photosensitizer for PDT of liver tumours is a potential interesting strategy...
  72. ncbi Hepatic tumor detection: MR imaging and conventional US versus pulse-inversion harmonic US of NC100100 during its reticuloendothelial system-specific phase
    Flemming Forsberg
    Department of Radiology, Division of Ultrasound, Thomas Jefferson University Hospital, Suite 763J, Main Bldg, 132 S 10th St, Philadelphia, PA 19107, USA
    Radiology 222:824-9. 2002
    ..To compare conventional ultrasonography (US) and magnetic resonance (MR) imaging with contrast agent-enhanced US for detection of VX-2 liver tumors in rabbits...
  73. ncbi Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells
    D W Crabb
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Alcohol Clin Exp Res 19:1414-9. 1995
    ..These data suggest that low Km ALDH2 can be regulated by hormones and may not be constitutive as previously thought, and that the HuH7 ALDH is regulated differently...
  74. ncbi CCAAT enhancer-binding protein alpha suppresses the rat placental glutathione S-transferase gene in normal liver
    Hiromi Ikeda
    Departments of Biochemistry and Ophthalmology, Hokkaido University Graduate School of Medicine, N15, W7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 281:6734-41. 2006
    ..These results indicate that C/EBPalpha is a negative regulator of GST-P gene expression in normal liver...
  75. ncbi Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions
    F Marotta
    Hepato Gastroenterology Unit, S Giuseppe Hospital, Milan, Italy
    Ann Hepatol 5:268-72. 2006
    ..It is concluded that herbal compound YHK by preventing hepatocarcinogenesis in DEN-induced liver preneoplastic lesions in rats has the potential to a large clinical application as a functional food...
  76. pmc Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma
    Elizabeth M Jablonski
    Department of Biology, UNC at Charlotte, 9201 University City Blvd, Charlotte, NC, USA
    Cancer Lett 250:36-46. 2007
    ..In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation...
  77. ncbi Antiproliferative effects of 5-fluorouracil and interferon-alpha in combination on a hepatocellular carcinoma cell line in vitro and in vivo
    Sakiko Kojiro
    Department of Pathology, Kurume University School of Medicine and Research Center of Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University, Kurume, Japan
    J Gastroenterol Hepatol 21:129-37. 2006
    ..We investigated the antiproliferative effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) in combination on a hepatocellular carcinoma (HCC) cell line...
  78. ncbi N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells
    Xing Zhong Wu
    Department of Biochemistry, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    Cell Biol Int 30:672-80. 2006
    ..We conclude that ATRP is an alternative inhibitor and potential therapeutic agent for HCC metastasis with a different mechanism of action from ATRP...
  79. ncbi Pronounced inhibitory effect of chlorcyclizine (CCZ) in experimental hepatocarcinoma
    Sujata G Dastidar
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    In Vivo 20:97-102. 2006
    ..A decrease in the number of nodules was observed in the CCZ-treated group...
  80. ncbi Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors
    C Thirunavukkarasu
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, 600113, Chennai, India
    Pharmacol Res 48:167-73. 2003
    ..Our results emphasize the role of sodium selenite in cancer and strongly indicate its role as an essential micronutrient in cancer chemoprevention and therapy...
  81. ncbi Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases--activation of cell invasion and migration pathways
    Kwan Man
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 13:1669-77. 2007
    ..In conclusion, hepatic I/R injury of a small liver remnant exacerbated liver tumor growth and metastasis by marked activation of cell adhesion, invasion, and angiogenesis pathways...
  82. ncbi Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model
    Akira Miki
    Division of Molecular Medicine and Medical Genetics, International Center of Medical Research and Treatment, Kobe University Graduate School of Medicine, Kusunoki cho, Kobe 650 0017, Japan
    Int J Oncol 32:603-8. 2008
    ..The inhibitory effect of the PEG-IFN and IFN on hepatocarcinogenesis was almost the same, and this might be induced by the Fas-related apoptosis in the surrounding tissues...
  83. ncbi Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin
    Venkatabalasubramanian Sivaramakrishnan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India
    Chem Biol Interact 171:79-88. 2008
    ..In conclusion, these findings indicate that morin prevents lipid peroxidation, hepatic cell damage and protects the antioxidant system in N-nitrosodiethylamine-induced hepatocellular carcinogenesis...
  84. ncbi [Study of antitumous effect of the complex prescription of Chinese crude drug in athymic mice with HCC]
    Bao Guo Sun
    First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhong Yao Cai 30:1417-21. 2007
    ..To research the treatment effect of a complex prescription of Chinese crude drug in BALB/c athymic mice...
  85. ncbi Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc
    N Kurabe
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda shi, Chiba, Japan
    Oncogene 26:5626-34. 2007
    ..These results show that rSGF29 is a novel component of TFTC/STAGA complexes and could be involved in the c-Myc-mediated malignant transformation...
  86. ncbi Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats
    Jihei Nishimura
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo, Japan
    Arch Toxicol 82:641-54. 2008
    ..These results suggest that oxidative stress is involved in the development of FF-induced hepatocellular preneoplastic foci in rats...
  87. ncbi Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas
    Hongchi Jiang
    The Hepatosplenic Surgery Center, Department of General Surgery, The First Clinical Medical School of Harbin Medical University, Harbin, China
    Int J Cancer 121:416-24. 2007
    ..In conclusion, these encouraging results warrant future investigation of the use of antiangiogenic therapy for enhancing the therapeutic efficacy of TAE to treat unresectable liver cancers...
  88. ncbi Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 45:1160-4. 2007
    ..The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis...
  89. ncbi Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases
    Marta Vallejo
    Laboratory of Experimental Hepatology and Drug Targeting HEVEFARM, CIBER HEPAD, University of Salamanca, 37007 Salamanca, Spain
    Biochem Pharmacol 73:1394-404. 2007
    ..In conclusion, our results support the hypothesis that cytostatic bile acid derivatives such as BANB-6 may offer a useful pharmacological strategy for the treatment of tumors of the enterohepatic circuit...
  90. ncbi Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 14 40126 Bologna, Italy
    Eur J Pharm Sci 30:136-42. 2007
    ..L-HSA-DOXO, by avoiding DOXO accumulation in bone marrow is an attractive candidate for clinical trials against tumors which were found to actively internalize this conjugate in laboratory animals, such as hepatocellular carcinoma...
  91. ncbi Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice
    Mitsuyoshi Moto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, 183 8509 Tokyo, Japan
    Toxicol Pathol 34:744-51. 2006
    ..These results suggest the possibility that the inhibition of apoptosis and a failure in the ability to repair oxidative DNA damage occur in the hepatocellular DC-induced tumors in mice...
  92. ncbi Oridonin-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) copolymer nanoparticles: preparation, characterization, and antitumor activity on mice with transplanted hepatoma
    Nianping Feng
    Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai, P R China
    J Drug Target 16:479-85. 2008
    ..Thus, ORI-PCL-PEO-PCL-NPs may be used as a promising delivery system for liver cancer treatment...
  93. ncbi Consistent liver metastases in a rat model by portal injection of microencapsulated cancer cells
    Tsuyoshi Enomoto
    Department of Surgery, University of Tsukuba, Ibaraki, Japan
    Cancer Res 66:11131-9. 2006
    ....
  94. ncbi Molecular cytogenetic characteristics of the human hepatocellular carcinoma cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization
    Jiong Yang
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, People s Republic of China
    Cancer Genet Cytogenet 158:180-3. 2005
    ..The analysis of this cell line through a combination of molecular cytogenetic techniques provides information on the possible molecular mechanisms involved in the metastatic process of HCC...
  95. ncbi [Calcium-binding protein S100A2 in the retardation of growth and proliferation of hepatocellular carcinoma cells]
    X Wang
    Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China
    Zhonghua Zhong Liu Za Zhi 23:363-5. 2001
    ..CONCLUSION: The exogenous S100A2 is able to check the QGY7701 cell cycle, stop the cell growth and proliferation either in vitro or in vivo in the QGY7701 cells...
  96. pmc Selective accumulation of ALA-induced PpIX and photodynamic effect in chemically induced hepatocellular carcinoma
    M Otake
    Second Department of Internal Medicine, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka 431 3192, Japan
    Br J Cancer 89:730-6. 2003
    ..Antitumour effect was more evident in HCC than in the nontumoral tissue surrounding HCC. These findings suggest the possibility to detect HCC by fluorescence and to treat HCC by light...
  97. ncbi [Treatment of hepatocellular carcinoma by transfecting interleukin-12 and interleukin-2 fusion gene intrasplenically, an experimental study]
    Jia He Yang
    Eastern Hepatobilliary Surgery Hospital, Second Military Medical University Shanghai 200438, China
    Zhonghua Yi Xue Za Zhi 83:740-3. 2003
    ..To study the inhibitory effect of retroviral packaging cells injected intrasplenically encoding mouse interleukin-12 (mIL-12) and human interleukin-2 (hIL-2) fusion gene on the growth of hepatocellular carcinoma...
  98. ncbi Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo
    Akinori Sugiyama
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Yamazaki 2641, Noda shi, Chiba 278 8510, Japan
    Carcinogenesis 24:1549-59. 2003
    ..In addition, over-expression of 14-3-3beta mRNA was observed in various murine tumor cell lines. These results suggest that 14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo...
  99. ncbi Mechanism of interferon alpha on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice
    Lu Wang
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, Peoples Republic of China
    J Gastrointest Surg 7:587-94. 2003
    ..IFN-alpha inhibits metastasis and recurrence of human HCC after curative resection in nude mice mediated by antiangiogenesis through downregulating expression of vascular endothelial growth factor but not basic fibroblast growth factor...
  100. ncbi A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay
    Y C Ou
    Center for Environmental Toxicology and Technology, Department of Environmental Health, Colorado State University, Fort Collins 80523, USA
    Cancer Res 61:1879-89. 2001
    ..This simulation work is an example of quantitative approaches that could be useful for the analysis of other initiation-promotion studies...
  101. ncbi A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals
    Nobuyuki Ito
    Nagoya City University, 1 Kawasumi, Mizuho ku, Nagoya 467 8601
    Cancer Sci 94:3-8. 2003
    ....

Research Grants65

  1. Polyamine Suppression By Antizyme inducing Analogs
    John Mitchell; Fiscal Year: 2002
    ..These studies will provide an essential foundation for further exploration of the chemical induction of antizyme as a means of chemoprevention in animals. ..
  2. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  3. Prevention of Cigarette Smoke-Induced Lung Cancer by Dietary Selenium
    HOWARD GLAUERT; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. STEM CELLS AND HEPATOCARCINOGENESIS
    Stewart Sell; Fiscal Year: 2009
    ..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..
  5. Dietary Antioxidants, NF-KappaBeta, and Carcinogenesis
    HOWARD GLAUERT; Fiscal Year: 2002
    ..These results will provide a mechanistic basis for possible dietary recommendations to prevent cancer. ..
  6. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
    ..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
  7. AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICE
    Stewart Sell; Fiscal Year: 2002
    ..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
  8. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2010
    ..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
  9. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2008
    ..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
  10. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  11. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. Comparative genomics of species-specific tumor promotion
    Russell Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  13. Gap Junction Assembly: Mechanisms and Regulation
    ROSS JOHNSON; Fiscal Year: 2006
    ..Finally, "pull-down" experiments will identify proteins associating with Cx43, in response to cAMP, and various biochemical techniques will be used to study wild type and mutant Cx43 in fibroblasts. ..
  14. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  15. Oxidative Damage to DNA Repair Pathways
    Cameron Koch; Fiscal Year: 2006
    ..Specific Aim 3 will investigate other aspects of DNA repair and DNA structural organization to determine their sensitivity to redox regulation. ..
  16. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  17. Molecular-Specific Detection of Tumors: MRI Investigations
    Rheal Towner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Phase I Clinical Translation Trial of Oncolytic rVSV-F Virotherapy for HCC
    Savio L Woo; Fiscal Year: 2010
    ....
  19. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. [unreadable] [unreadable] [unreadable]..
  20. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Mutant mouse models of exocrine pancreatic cancer
    DAVID TUVESON; Fiscal Year: 2008
    ..Information gained from this murine model should facilitate further understanding of human pancreatic cancer. ..
  22. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  23. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2008
    ..abstract_text> ..
  24. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  25. Anaerobic Bacteria as Therapeutic Agents for Metastatic Cancer
    Savio Woo; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. STATISTICAL METHODS FOR CORRELATED SUBSTANCE USE DATA
    Heping Zhang; Fiscal Year: 2003
    ....
  27. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  28. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  29. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  30. Cancer Risk Assessment: Is There New Science to Apply?
    Richard Bull; Fiscal Year: 2002
    ..A summary of the meeting will be prepared and this along with any conclusions and recommendations will be submitted to a peer-reviewed journal for publication. ..
  31. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  32. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael D Roth; Fiscal Year: 2010
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  33. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2009
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  34. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  35. HUMAN FETAL LIVER GST--HYDROXYNONENAL CONJUGATION
    Evan Gallagher; Fiscal Year: 2002
    ..In addition, this project has important implications in terms of the in utero effects of pro-oxidant drugs or chemicals to which pregnant women are exposed. ..
  36. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  37. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  38. Training Program in Molecular and Cellular Toxicology
    John Reiners; Fiscal Year: 2008
    ..It is envisioned that students with such training will be better equipped to pursue postdoctoral research at major research laboratories throughout the United States. ..
  39. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ....
  40. RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGING
    Stanislav Kasl; Fiscal Year: 2008
    ..In addition, Ph.D. candidates in biostatistics who will work with our biostatistics faculty on developing new techniques for the analysis of longitudinal data on older persons will also be eligible for support. ..
  41. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  42. FASEB Summer Research Conference 2008 - Melatonin Receptors: Actions and Therapeu
    David Blask; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  43. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
    ..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
  44. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  45. Suppression of Hepatic Gluconeogenesis in IDDM
    Savio Woo; Fiscal Year: 2004
    ..The research proposed in this project can potentially lead to development of an effective and safe adjuvant treatment to complement insulin therapy and significantly improve glycemic control in patients with IDDM. ..
  46. Vector Core Production Facility at Mount Sinai
    Savio Woo; Fiscal Year: 2006
    ..abstract_text> ..
  47. Adjuvant immunotherapy for non-small cell lung cancer
    Michael Roth; Fiscal Year: 2005
    ..abstract_text> ..
  48. Genetic Reconstitution for Phenylketonuria
    Savio Woo; Fiscal Year: 2006
    ..abstract_text> ..
  49. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..This translational study combining the use of radiological and basic science research tools is both necessary and fundamental to firmly lay the groundwork for clinical trials. ..
  50. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..abstract_text> ..
  51. PATHWAYS TO ALCOHOLISM THROUGH PSYCHOPATHOLOGY
    Heping Zhang; Fiscal Year: 2001
    ..They further state that identifying these pathways will ultimately assist in the development of an empirical basis for the primary prevention of secondary alcoholism. ..
  52. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Michael Roth; Fiscal Year: 2006
    ..abstract_text> ..
  53. HEPATIC INSULIN GENE EXPRESSION IN IDDM
    Savio Woo; Fiscal Year: 2001
    ..Successful conduct of the proposed research will lead to the development of a novel modality for adjuvant treatment of IDDM in humans. ..
  54. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  55. Predicting Radiation Response by Tumor pO2
    Cameron Koch; Fiscal Year: 2006
    ..DDFP may thus be the first PFC emulsion practical and safe for use in multifraction clinical regimens. ..
  56. INSTABILITY OF TUMOR PROMOTION IN HEPATOCARCINOGENESIS
    HENRY PITOT JR; Fiscal Year: 2006
    ..abstract_text> ..
  57. FRA16D CHROMOSOMAL FRAGILE SITE IN LIVER CARCINOGENESIS
    Lewis Roberts; Fiscal Year: 2003
    ..This will enable me to obtain the training and preliminary data I need to launch an independent, productive research career. ..
  58. MOLECULAR PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Lewis Roberts; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into the molecular pathogenesis of HCC, and may lead to the development of novel chemotherapeutic strategies against HCC. ..
  59. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..abstract_text> ..
  60. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  61. Role of Kupffer Cell in Hepatic Carcinogenesis
    James Klaunig; Fiscal Year: 2009
    ..These studies will further our understanding into the mechanisms of the development and progression of human liver cancer with potential application to prevention and therapy. ..
  62. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..