Genomes and Genes
juvenile rheumatoid arthritis
Summary: Rheumatoid arthritis of children occurring in three major subtypes defined by the symptoms present during the first six months following onset: systemic-onset (Still's Disease, Juvenile-Onset), polyarticular-onset, and pauciarticular-onset. Adult-onset cases of Still's disease (STILL'S DISEASE, ADULT-ONSET) are also known. Only one subtype of juvenile rheumatoid arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
Publications278 found, 100 shown here
- Juvenile idiopathic arthritisAngelo Ravelli
Department of Paediatrics, University of Genoa and Institute G Gaslini, Genoa, Italy
Lancet 369:767-78. 2007....
- Juvenile rheumatoid arthritis of the knee: evaluation with USD Sureda
Department of Radiology, Ciutat Sanitària i Universitària Vall d Hebron, Autonomous University of Barcelona, Spain
Radiology 190:403-6. 1994To evaluate the value of ultrasound (US) in assessing joint inflammation in patients with juvenile rheumatoid arthritis (JRA) of the knee.
- Bartonella infection associated with systemic juvenile rheumatoid arthritisM Tsukahara
Faculty of Health Sciences, Yamaguchi University School of Medicine, Ube City, Japan
Clin Infect Dis 32:E22-3. 2001A 4-year-old girl with systemic juvenile rheumatoid arthritis had Bartonella infection diagnosed serologically...
- A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritisR P Donn
Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
Arthritis Rheum 44:1782-5. 2001..To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA)...
- International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001Ross E Petty
Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
J Rheumatol 31:390-2. 2004
- Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritisCarol A Wallace
Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105, USA
J Rheumatol 31:2290-4. 2004..To develop preliminary criteria for inactive disease and clinical remission for select categories of juvenile idiopathic arthritis (JIA), and to decide what such clinical states should predict in terms of probability of disease recurrence...
- A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexateNicolino Ruperto
IRCCS G Gaslini, University of Genoa, Genoa, Italy
Arthritis Rheum 50:2191-201. 2004..5 mg/m(2)/week)...
- A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritisNicolino Ruperto
IRCCS, Istituto G Gaslini, Genoa, Italy
Arthritis Rheum 56:3096-106. 2007To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA).
- Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritisJames W Verbsky
Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Lousis Children s Hospital, Missouri 63110, USA
J Rheumatol 31:2071-5. 2004Systemic onset juvenile rheumatoid arthritis (SOJRA) is a multisystem disease characterized by high fever, rash, arthritis, serositis, splenomegaly, and laboratory evidence of systemic inflammation...
- Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA RegistryG Horneff
Department of Paediatrics, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany
Ann Rheum Dis 68:519-25. 2009..The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA...
- Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)Edward M Behrens
Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
J Rheumatol 35:343-8. 2008To characterize the initial clinical and laboratory features of patients with systemic onset juvenile rheumatoid arthritis (soJRA) through a Web-based registry.
- Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritisChristian Huemer
Department of Pediatrics, University of Vienna, Austria
J Rheumatol 29:1531-5. 2002..patients with oligoarticular onset juvenile psoriatic arthritis (Oligo-JPsA) and pauciarticular onset juvenile rheumatoid arthritis (Pauci-JRA) in order to estimate the predictive performance of specific patterns for the diagnosis of ..
- Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritisAmita Aggarwal
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014
Rheumatol Int 23:134-7. 2003..MTX) is one of the most widely used disease-modifying antirheumatoid drugs in the treatment of juvenile rheumatoid arthritis (JRA)...
- Macrophage activation syndromeAngelo Ravelli
Pediatria II, Istituto G Gaslini, Universita di Genova, Italy
Curr Opin Rheumatol 14:548-52. 2002..Cyclosporin A has been found effective in patients with corticosteroid-resistant MAS. A recent report has suggested that etanercept may be a useful adjunctive therapeutic agent...
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part ICharles G Helmick
CDC, Atlanta, Georgia 30341 3717, USA
Arthritis Rheum 58:15-25. 2008..A companion article (part II) addresses additional conditions...
- Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric populationSilvia Jiménez-Morales
Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
Hum Immunol 70:251-6. 2009..238G/A TNF-alpha polymorphisms were associated with asthma, systemic lupus erythematosus (SLE), and juvenile rheumatoid arthritis (JRA) in a pediatric Mexican population...
- Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?Seza Ozen
Department of Pediatrics, Hacettepe University, 06100 Ankara, Turkey
J Rheumatol 30:2014-8. 2003..We also prospectively evaluated 72 patients with childhood rheumatic diseases for the presence of MEFV mutations...
- Medical treatment of juvenile idiopathic arthritisPhilip J Hashkes
Section of Pediatric Rheumatology, Department of Rheumatic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
JAMA 294:1671-84. 2005..The treatment of juvenile idiopathic arthritis (JIA) has changed markedly in the last 15 years. Many children with JIA are not treated by pediatric rheumatologists...
- Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset typePierre Quartier
Hopital Necker Enfants Malades, Paris, France
Arthritis Rheum 48:1093-101. 2003..To assess the efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA), and to assess the tolerance of these patients to etanercept...
- Incidence and outcomes of uveitis in juvenile rheumatoid arthritis, a synthesis of the literaturePetros E Carvounis
Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Graefes Arch Clin Exp Ophthalmol 244:281-90. 2006b>Juvenile rheumatoid arthritis (JRA) is the most common systemic cause of pediatric uveitis in Europe and North America...
- Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritisJocelyn Sicat
Department of Rheumatology, Tufts New England Medical Center, Boston, Massachusetts, USA
J Rheumatol 32:1821-31. 2005..We measured the expression and the ability of interferon-alpha (IFN-alpha) to induce the human endogenous retrovirus HERV-K18 superantigen in juvenile rheumatoid arthritis (JRA) and pediatric systemic lupus erythematosus (SLE).
- Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathyK Nistala
Paediatric Rheumatology Unit, Great Ormond Street Hospital, London, England
J Rheumatol 28:2125-8. 2001We describe 2 pediatric patients with sickle cell disease (SCD) who developed seropositive juvenile rheumatoid arthritis (JRA). Both patients have severe joint damage, the compound effect of both disease processes...
- Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritisB D Carter
University of Louisville School of Medicine, Louisville, Kentucky, USA
Pediatrics 103:975-9. 1999..To determine if psychological morbidity in youth with chronic fatigue is caused by the stress of coping with a chronic illness...
- Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritisAngelo Ravelli
Department of Pediatrics, Division of Pediatrics II, University of Genoa, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
J Pediatr 146:598-604. 2005..To develop diagnostic guidelines for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (S-JIA)...
- Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritisCristina Meazza
University of Pavia, IRCCS Policlinico San Matteo, Italy
Arthritis Rheum 46:232-7. 2002..To evaluate serum and synovial fluid (SF) levels of macrophage migration inhibitory factor (MIF) and in vitro MIF production by peripheral blood mononuclear cells (PBMCs) in patients with juvenile idiopathic arthritis (JIA)...
- Different familial association patterns of autoimmune diseases between juvenile-onset systemic lupus erythematosus and juvenile rheumatoid arthritisChun mei Huang
Department of Pediatrics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan 100, ROC
J Microbiol Immunol Infect 37:88-94. 2004..of patients with systemic lupus erythematosus (SLE) is greater than that of relatives of patients with juvenile rheumatoid arthritis (JRA)...
- Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritisDavid C Wilson
Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA
Arthritis Rheum 62:2510-6. 2010To examine both the source of follistatin-like protein 1 (FSTL-1) and the factors that induce its expression in arthritis, and to determine whether juvenile rheumatoid arthritis (JRA) is characterized by overexpression of FSTL-1.
- Role of power Doppler sonography in evaluation of therapeutic response of the knee in juvenile rheumatoid arthritisC Shanmugavel
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh 160012, India
Rheumatol Int 28:573-8. 2008..is to study the role of power Doppler sonography (PDS) in assessment of therapeutic response in juvenile rheumatoid arthritis (JRA) of knee joint...
- Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et alNobuaki Maeno
Arthritis Rheum 46:2539-41; author reply 2541-2. 2002
- The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritisJack Bleesing
Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 56:965-71. 2007..This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA)...
- Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantationN M Wulffraat
Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, The Netherlands
Ann Rheum Dis 62:236-41. 2003....
- Tumour necrosis factor alpha G-->A -238 and G-->A -308 polymorphisms in juvenile idiopathic arthritisS Ozen
Department of Paediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Rheumatology (Oxford) 41:223-7. 2002..We analysed whether there were any associations between these polymorphisms and the type of JIA and/or the clinical course of the disease in two populations...
- The British version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)J Nugent
Institute of Child Health, University College, London, United Kingdom
Clin Exp Rheumatol 19:S163-7. 2001..In conclusion the British version of the CHAQ-CHQ is a reliable, and valid tool for the functional, physical and psychosocial assessment of children with JIA...
- Prevention of nonadherence to nonsteroidal anti-inflammatory medications for newly diagnosed patients with juvenile rheumatoid arthritisMichael A Rapoff
Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160 7330, USA
Health Psychol 21:620-3. 2002..the anticipated drop in adherence to nonsteroidal medications among newly diagnosed patients with juvenile rheumatoid arthritis. Thirty-four participants completed the study (mean age = 8.44 years, SD = 3...
- Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodologyN Ruperto
Laboratorio di Informatica Medica, IRCCS San Matteo, University of Pavia, Pavia, Italy
Clin Exp Rheumatol 19:S1-9. 2001..The results of the present study show that cross-cultural adaptation is a valid process to obtain reliable instruments for the different socio-economic and socio-demographic conditions of the countries participating in the project...
- Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter studyNorman Ilowite
Schneider Children s Hospital, New Hyde Park, NY 10467, USA
Clin Rheumatol 28:129-37. 2009..efficacy of the interleukin-1 receptor antagonist anakinra in patients with polyarticular-course juvenile rheumatoid arthritis (JRA)...
- Gastrointestinal symptoms and their association with health-related quality of life of children with juvenile rheumatoid arthritis: validation of a gastrointestinal symptom questionnaireHermine I Brunner
Division of Rheumatology E 4010, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Clin Rheumatol 11:194-204. 2005..perform an initial validation of the Gastrointestinal Symptom Scale for Kids (GISSK) in children with juvenile rheumatoid arthritis (JRA); and too evaluate the relationship between gastrointestinal (GI) symptoms and health-related ..
- Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal studyN J Peake
Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
Rheumatology (Oxford) 44:1383-9. 2005....
- The German etanercept registry for treatment of juvenile idiopathic arthritisG Horneff
Department of Paediatrics, University Medical Centre, Martin Luther University, Halle Wittenberg, Germany
Ann Rheum Dis 63:1638-44. 2004..To describe a registry set up to monitor children treated with etanercept in Germany and Austria...
- Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in FranceT Lequerre
Rheumatology Department, Rouen University Hospital and Inserm 905, 76031 Rouen, France
Ann Rheum Dis 67:302-8. 2008..Anakinra treatment has been reported to be effective in some patients with systemic-onset juvenile idiopathic arthritis (SoJIA) or adult-onset Still disease (AoSD)...
- The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis familiesEmma M Ogilvie
University College London, London, UK
Arthritis Rheum 48:3202-6. 2003..The present study was undertaken to confirm the previous findings and to assess possible association with variations of the A(n)T(n) tract in the promoter...
- Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritisElena M O Felin
University of Utah, Salt Lake City, UT 84158, USA
Arthritis Rheum 56:984-94. 2007..computed tomography (pQCT), compared with general bone characteristics as measured using dual x-ray absorptiometry (DXA), and to assess their relationship to disease-related factors in children with juvenile rheumatoid arthritis (JRA).
- Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritisSampath Prahalad
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA
Arthritis Rheum 46:1851-6. 2002To determine if the prevalence of autoimmunity among relatives of patients with juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer control subjects.
- A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritisA B Begovich
Department of Human Genetics, Cetus Corporation, Emeryville, CA 94608
Proc Natl Acad Sci U S A 86:9489-93. 1989..format to type samples amplified by the polymerase chain reaction from 44 patients with pauciarticular juvenile rheumatoid arthritis, 32 patients with adult rheumatoid arthritis, and 50 random controls...
- Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockadeFlorence Allantaz
Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
J Exp Med 204:2131-44. 2007..Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities...
- Arthrosonography of hip and knee joints in the follow up of juvenile rheumatoid arthritisM Frosch
Department of Paediatrics, University of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
Ann Rheum Dis 62:242-4. 2003To evaluate sensitivity of arthrosonography of hip and knee joints for monitoring disease activity in juvenile rheumatoid arthritis (JRA).
- Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA)A Aggarwal
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Clin Exp Immunol 148:515-9. 2007..05). TARC/CCL17 levels in SF were lower than serum. There is increased homing of CCR5 and CXCR3(+) CD4 cells to the SF. Increased SF levels of IP-10/CXCL10 may be responsible for this migration in patients with ERA...
- Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter studyThomas J A Lehman
Division of Pediatric Rheumatology, Hospital for Special Surgery, and the Department of Pediatrics, Sanford Weill Medical College of Cornell University, New York, New York, USA
J Pediatr 145:856-7. 2004Thirteen children with difficult systemic onset juvenile rheumatoid arthritis were treated with thalidomide. At 6 months, 11 of the 13 were able to reduce their use of prednisone ( P < ...
- Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrationsDirk Foell
Institute of Experimental Dermatology and Department of Pediatrics, University of Muenster, Muenster, Germany
Arthritis Rheum 50:1286-95. 2004..The aim of our study was to determine neutrophil activation in juvenile rheumatoid arthritis (JRA) by analyzing S100A12 (EN-RAGE; calgranulin C), a proinflammatory protein secreted by human ..
- Sleep quality in children with juvenile rheumatoid arthritisSusan E Labyak
Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle 98195 7262, USA
Holist Nurs Pract 17:193-200. 2003Children with juvenile rheumatoid arthritis (JRA) report poor sleep quality, daytime sleepiness, fatigue, anxiety, and altered mood. Sleep disturbances in school-aged children are an issue of serious concern...
- Polysomnography and self-reported sleep, pain, fatigue, and anxiety in children with active and inactive juvenile rheumatoid arthritisTeresa M Ward
Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, 98195 7266, USA
J Pediatr Psychol 33:232-41. 2008To compare polysomnography (PSG) and self-reported sleep, symptoms (pain and fatigue), and anxiety between children with active and inactive juvenile rheumatoid arthritis (JRA) and examine relations among sleep, symptoms, and anxiety.
- Quantifying dynamic contrast-enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parametersDagnachew W Workie
Department of Physics, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Magn Reson Med 54:560-8. 2005..This work deals with modeling of DCE-MRI data from the knees of children with a history of juvenile rheumatoid arthritis (JRA) by using an AIF extracted from the signal enhancement data from the nearby popliteal artery...
- Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndromeNdate Fall
Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Arthritis Rheum 56:3793-804. 2007..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...
- Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort studyKoert M Dolman
Department of Pediatric Hematology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, 1105 AZ, The Netherlands
Arthritis Res Ther 10:R32. 2008..The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis (JRA) and whether MBL2 genotypes are associated with JRA severity.
- Factors associated with the use of complementary and alternative medicine in juvenile idiopathic arthritisDebbie Ehrmann Feldman
Universite de Montreal, Montreal, Quebec, Canada
Arthritis Rheum 51:527-32. 2004....
- Prognostic factors in juvenile rheumatoid arthritis: a case-control study revealing early predictors and outcome after 14.9 yearsBerit Flatø
Center for Rheumatic Diseases, Rikshospitalet University Hospital, Oslo, Norway
J Rheumatol 30:386-93. 2003To describe the physical and psychosocial outcome in patients with juvenile rheumatoid arthritis (JRA), compared with subjects in the general population, and to determine patient characteristics, HLA alleles, and disease variables within ..
- Growth patterns in juvenile rheumatoid arthritisJ J Liem
Section of Rheumatology, Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada
Clin Exp Rheumatol 21:663-8. 2003To define patterns of growth in juvenile rheumatoid arthritis (JRA) and to evaluate possible associated clinical and laboratory correlates.
- Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synoviaClaudia R Ruprecht
Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
J Exp Med 201:1793-803. 2005....
- A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritisJennifer Reiter-Purtill
Division of Hematology Oncology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
J Pediatr Psychol 28:17-28. 2003To complete an assessment of social functioning of children with juvenile rheumatoid arthritis (JRA) and nonchronically ill controls who had been evaluated 2 years earlier (Noll et al...
- Toward an understanding of the long-term outcome of juvenile idiopathic arthritisA Ravelli
Clin Exp Rheumatol 22:271-5. 2004....
- Worldwide prevalence of juvenile arthritis why does it vary so much?Prudence Joan Manners
Department of Paediatrics, University of Western Australia, Perth, Australia
J Rheumatol 29:1520-30. 2002..JA is the term used here collectively for juvenile rheumatoid arthritis, juvenile chronic arthritis, or juvenile idiopathic arthritis as defined in the respective published ..
- Comparative epidemiology of the rheumatic diseases in childrenK Oen
Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Curr Opin Rheumatol 12:410-4. 2000..Other publications during the past year have updated the epidemiology of Kawasaki disease, Behcet disease, and acute rheumatic fever...
- The clinical meaning of functional outcome scores in children with juvenile arthritisH Dempster
University of Toronto, Ontario, Canada
Arthritis Rheum 44:1768-74. 2001..CONCLUSION: Clinicians, as well as researchers setting protocols, should aim for a mimimum improvement of 0.13 in the CHAQ score when treating pediatric patients with arthritis...
- A case-control sleep study in children with polyarticular juvenile rheumatoid arthritisCassia M Passarelli
Department of Pediatrics, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
J Rheumatol 33:796-802. 2006To investigate the relationship between clinical manifestations and sleep abnormalities in patients with juvenile rheumatoid arthritis (JRA).
- A prospective study comparing celecoxib with naproxen in children with juvenile rheumatoid arthritisIvan Foeldvari
Hamburger Zentrum für Kinder und Jugendrheumatologie, am Klinikum Eilbek, Dehnhaide 120, 22081 Hamburg, Germany
J Rheumatol 36:174-82. 2009To compare the efficacy and safety of celecoxib and naproxen in children with juvenile rheumatoid arthritis (JRA).
- Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritisMichael A Rapoff
University of Kansas Medical Center, Kansas City, KS 66160 7330, USA
Arthritis Rheum 53:905-10. 2005..patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease-related variables as potential predictors of adherence.
- Adalimumab with or without methotrexate in juvenile rheumatoid arthritisDaniel J Lovell
Cincinnati Children s Hospital Medical Center, Division of Rheumatology, Location E, Rm 2 129, MLC 4010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
N Engl J Med 359:810-20. 2008Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF antibody, in children with polyarticular-course juvenile rheumatoid ..
- The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritisBerit Flatø
Center for Rheumatic Diseases, Rikshospitalet University Hospital, Oslo, Norway
Arthritis Rheum 46:986-94. 2002....
- Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritisRebecca Lamb
Arthritis Research Campaign Epidemiology Unit and Centre for Molecular Medicine, University of Manchester, Manchester, UK
Arthritis Rheum 56:1286-91. 2007..To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA)...
- Brief report: use of complementary and alternative medicine and psychological functioning in Latino children with juvenile idiopathic arthritis or arthralgiaKathy Zebracki
Loyola University Chicago, Department of Psychology, IL 60626, USA
J Pediatr Psychol 32:1006-10. 2007..To describe the use of complementary and alternative medicine (CAM) and its relationship to symptoms of anxiety, depression, and dysthymia in Latino children with juvenile idiopathic arthritis (JIA) or arthralgia...
- Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritisChristine R Culy
Adis International Limited, Auckland, New Zealand
Drugs 62:2493-537. 2002..In patients with polyarticular-course juvenile rheumatoid arthritis, etanercept resulted in improvements in all measures of disease activity and was significantly more ..
- Juvenile rheumatoid arthritis: physical therapy and rehabilitationAysegul Cakmak
Department of Physical Medicine and Rehabilitation, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
South Med J 98:212-6. 2005..This article summarizes the objectives and methods of physical therapy and rehabilitation that are important parts of treatment...
- Adenosine deaminase activity and its isoenzyme pattern in patients with juvenile rheumatoid arthritis and systemic lupus erythematosusS Hitoglou
Aristotle University of Thessaloniki, Greece
Clin Rheumatol 20:411-6. 2001..and its isoenzymes ADA1 and ADA2 in serum and peripheral blood lymphocytes (PBLs) of children with juvenile rheumatoid arthritis (JRA) and systemic lupus erythematosus (SLE) in different phases of the diseases...
- Juvenile idiopathic arthritis: an updateJudyann C Olson
Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wis, USA
WMJ 102:45-50. 2003..Previous terminology identified this entity as juvenile rheumatoid arthritis. The 7 subsets of JIA identified under the new classification system are discussed, as are current ..
- Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthmaA Heinzmann
University Children s Hospital, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
Allergy 59:845-9. 2004..Our interest was to test polymorphisms of IL-18 for association with a typical TH1-mediated disease--juvenile idiopathic arthritis--and the TH2-mediated disease bronchial asthma in Caucasian children...
- Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritisBradley J Bloom
Department of Pediatrics, Hasbro Children s Hospital and Brown University School of Medicine, Providence, RI 02903, USA
J Rheumatol 29:169-73. 2002To determine what sleep abnormalities may exist in children with juvenile rheumatoid arthritis (JRA). and their relationship to pain, dysfunction. and disease activity.
- Total knee replacement in juvenile rheumatoid arthritisDavid E Rojer
Dept of Orthopedic Surgery, Stanford University Medical Center 300 Pasteur Dr, Stanford, CA 94305, USA
Orthopedics 28:39-45; quiz 46-7. 2005..times and in some cases increased blood requirements can be expected with TKA in patients with juvenile rheumatoid arthritis. Complications also are more frequent...
- Comparing parental distress, family functioning, and the role of social support for caregivers with and without a child with juvenile rheumatoid arthritisCynthia A Gerhardt
Division of Hematology Oncology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
J Pediatr Psychol 28:5-15. 2003To assess parental distress, family functioning, and social support among parents of children with a lifetime diagnosis of juvenile rheumatoid arthritis (JRA) and comparison families.
- Lowered IL-4-producing T cells and decreased IL-4 secretion in peripheral blood from subjects with juvenile rheumatoid arthritisJ L Huang
Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan, R O C
Chang Gung Med J 24:77-83. 2001To evaluate T helper 1 (Th1)/Th2 cells and cytokines in patients with three different subtypes of juvenile rheumatoid arthritis (JRA).
- Factors affecting clinical and therapeutic outcomes of patients with juvenile rheumatoid arthritisC T Hsu
Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China
Scand J Rheumatol 33:312-7. 2004To investigate clinical features, medications, and therapeutic responses of juvenile rheumatoid arthritis (JRA) among Taiwanese children.
- Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritisB B Bharti
Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
J Postgrad Med 50:262-5; discussion 266-7. 2004..echocardiographic studies of Left ventricular (LV) systolic and diastolic function in patients with juvenile rheumatoid arthritis (JRA), a study was carried out to study these parameters in these subjects...
- An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritisK L Rupert
Children s Hospital Research Foundation, Columbus, Ohio, USA
Exp Clin Immunogenet 16:81-97. 1999..polymorphism (RFLP) analysis was utilized to determine the RCCX modular variation in patients with juvenile rheumatoid arthritis (JRA)...
- Measuring the function of children with juvenile arthritisA Tennant
Rheumatology and Rehabilitation Research Unit, School of Medicine, The University of Leeds, Leeds, UK
Rheumatology (Oxford) 40:1274-8. 2001..Most showed poor levels of unidimensionality. CONCLUSION: Until new measures become available, the CHAQ appears to be the current 'best buy' for measuring function in children with arthritis...
- Coexistent sickle cell disease and juvenile rheumatoid arthritis: 2 cases with delayed diagnosis and severe destructive arthropathyB Anne Eberhard
J Rheumatol 29:1802; author reply 1802-3. 2002
- Care of the adult with juvenile rheumatoid arthritisPeter A Nigrovic
Center for Adults with Pediatric Rheumatic Illness, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, One Jimmy Fund Way, Smith 356, Boston, MA 02115, USA
Arthritis Rheum 55:208-16. 2006
- Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activityHanaa Mahmoud El Awady
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Pak J Biol Sci 10:1471-6. 2007..was conducted to investigate the abnormalities in early morning serum melatonin among patients with Juvenile Rheumatoid Arthritis (JRA) and to outline its relation to disease activity and severity...
- Association of RANTES promoter polymorphism with juvenile rheumatoid arthritisTsung Chieh Yao
Chang Gung Memorial Hospital, Chang Gung Children s Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
Arthritis Rheum 60:1173-8. 2009We recently reported that RANTES was a key molecule in the pathogenesis of juvenile rheumatoid arthritis (JRA) in a longitudinal cohort...
- Systemic juvenile rheumatoid arthritis: cognitive function and social adjustmentReinhold Feldmann
Department of Pediatrics, University Hospital of Munster, Munster, Germany
Ann Neurol 58:605-9. 2005..exist that focus on possible long-term risks for central nervous system involvement in systemic juvenile rheumatoid arthritis (SJRA). We investigated 31 children and adolescents with SJRA, aged 6 to 24 years (mean, 12...
- Renal involvement in juvenile rheumatoid arthritis: report of two casesA Gedalia
Department of Pediatrics, LSU Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
Clin Rheumatol 20:153-6. 2001Renal involvement is a rare occurrence in juvenile rheumatoid arthritis (JRA). We report on two JRA patients with kidney disease. The first was a 14-year-old African-American female with a 12-month history of polyarthritis...
- Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trialShumpei Yokota
Department of Paediatrics, Yokohama City University School of Medicine, Yokohama, Japan
Lancet 371:998-1006. 2008..We investigated the efficacy and safety of tocilizumab, an anti-interleukin-6-receptor monoclonal antibody, in children with this disorder...
- Novel IL-6 haplotypes and disease associationM S Fife
Pediatric and Adolescent Rheumatology, University College London, UK
Genes Immun 6:367-70. 2005..This suggests that the haplotype effect may be more functionally relevant to the disease...
- Etanercept in the treatment of macrophage activation syndromeS Prahalad
Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio 45229-3039, USA
J Rheumatol 28:2120-4. 2001Macrophage activation syndrome (MAS), a recognized complication of systemic juvenile rheumatoid arthritis (sJRA), has been associated with significant morbidity and mortality...
- Clinically diagnosed fatal cerebral vasculitis in long-standing juvenile rheumatoid arthritisGabriella Kiss
Virchows Arch 448:381-3. 2006
- Comparing the self-reported referral and management preferences of pediatricians and family physicians for children with juvenile rheumatoid arthritisGary L Freed
Child Health Evaluation and Research CHEAR Unit, Division of General Pediatrics, University of Michigan, 300 NIB 6E08, Ann Arbor, MI 48109 0456, USA
J Rheumatol 30:2700-4. 2003The symptoms of juvenile rheumatoid arthritis (JRA) are often first recognized by primary care physicians. Little is known about the determinants of the initial management and referral patterns of these physicians for children with JRA...
- Nutritional status and clinical characteristics in children with juvenile rheumatoid arthritisShou Ting Shin
Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 43:93-8. 2010The aim of the study was to investigate the clinical characteristics and nutritional status of juvenile rheumatoid arthritis (JRA) in Taiwanese children.
- Juvenile rheumatoid arthritisF Falcini
Department of Pediatric Rheumatology Unit, University of Florence, Faculty of Medicine, Firenze, Italy
Curr Opin Rheumatol 12:415-9. 2000..The immunopathogenesis of the diseases that are encompassed by the term juvenile rheumatoid arthritis is complex, and many studies have investigated the role of genetic and cytokine balance abnormalities...
- Surgical management of cataracts in children with juvenile rheumatoid arthritis-associated uveitisLinda A Lam
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Ophthalmol 135:772-8. 2003To evaluate outcomes of cataract surgery with posterior chamber intraocular lens (IOL) implantation with or without trabeculectomy in children with juvenile rheumatoid arthritis (JRA)-associated uveitis.
- Juvenile rheumatoid arthritis-like polyarthritis in Nijmegen breakage syndromeS D Rosenzweig
Servicio de Inmunologia, Hospital Nacional de Pediatria J P Garrahan, Buenos Aires, Argentina
J Rheumatol 28:2548-50. 2001..girl with all the clinical, immunological, and cytogenic characteristics described for NBS plus a juvenile rheumatoid arthritis-like syndrome...
- [Dietetic and anthropometric assessment in juvenile rheumatoid arthritis patients]Daniela Maria Alves Chaud
Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brasil
Rev Assoc Med Bras 49:181-4. 2003to evaluate the dietary intake and the anthropometry of children and adolescents with juvenile rheumatoid arthritis - JRA, considering the pauciarticular and the polyarticular types.
- Risk and resistance factors in the adaptation in mothers of children with juvenile rheumatoid arthritisJ C Manuel
Wake Forest University School of Medicine, Department of Public Health Sciences, Winston Salem, North Carolina 27157, USA
J Pediatr Psychol 26:237-46. 2001..severity, child functional status, psychosocial stress, intrapersonal factors, stress processing, and social-ecological factors in predicting psychological symptoms among mothers of children with juvenile rheumatoid arthritis (JRA).
- Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockadeVirginia Pascual
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Exp Med 201:1479-86. 2005..We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Behavioral Rx & Nutrition in Pediatric Chronic DiseaseLori J Stark; Fiscal Year: 2010..calcium has been equally effective in improving the calcium intake and bone accretion in children with juvenile rheumatoid arthritis and inflammatory bowel disease...
- Meso Scale Discovery Sector 6000 ImagerCHARLES ALFRED STANLEY; Fiscal Year: 2010..disease and renal transplantation, adolescent obesity, pediatric type 2 diabetes, cystic fibrosis, and juvenile rheumatoid arthritis. Overall, the multiplex immunoassay platform will expand our capacity to provide analysis of different ..
- Proteomic Profiles and Novel Biomarkers in Juvenile Rheumatoid ArthritisMargalit E Rosenkranz; Fiscal Year: 2010DESCRIPTION: (provided by applicant): Juvenile Rheumatoid Arthritis (JRA) comprises a heterogeneous group of childhood onset, chronic, autoimmune diseases with variable clinical presentations, outcomes and therapeutic responses...
- USE OF THERMAL AND 3D IMAGING TO QUANTIFY ARTHRITISRaphael Hirsch; Fiscal Year: 2010..by applicant): One of the biggest challenges in caring for patients with Rheumatoid Arthritis (RA) and Juvenile Rheumatoid Arthritis (JRA) is quantifying the degree of disease activity in any given joint...
- Kaiser Permanente Autoimmune Disease RegistryLisa J Herrinton; Fiscal Year: 2010..Registry will include all members of KP Northern California with prevalent rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and ankylosing spondylitis during the 15-year period 1996-2010...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMSophia Y Cleland; Fiscal Year: 2010..eliminate health disparities by characterizing the genetic bases for rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) between ethnic groups...
- RESEARCH REGISTRY FOR JUVENILE RHEUMATOID ARTHRITISMark Haggard; Fiscal Year: 2009b>Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare...
- LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITISRobert Colbert; Fiscal Year: 2001b>Juvenile rheumatoid arthritis (JRA) is a heterogeneous autoimmune disease likely to result from multiple genetic and environmental factors...
- PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TESMICHELLE URBAN; Fiscal Year: 1999..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
- PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TESJohn McGuire; Fiscal Year: 2001..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
- PULSE THERAPY IN SYSTEMIC JUVENILE RHEUMATOID ARTHRITISDaniel Lovell; Fiscal Year: 2000DESCRIPTION (adapted from applicant's abstract): Systemic juvenile rheumatoid arthritis (sJRA) is associated with significant long term morbidity and mortality...
- HLA-DP SEQUENCE POLYMORPHISM AND DISEASE PREDISPOSITIONHenry Erlich; Fiscal Year: 2003..We will focus on three diseases: pauciarticular juvenile rheumatoid arthritis, type 1 diabetes, and cervical carcinoma...
- Hepcidin Expression in the Anemia of Chronic DiseaseDavid Weinstein; Fiscal Year: 2007..homeostasis and hepcidin expression will be studied in normal and pathologic states including GSD1a, juvenile rheumatoid arthritis, and inflammatory bowel disease...
- Adeno-Associated Virus-Mediated Synovial Gene TransferRaphael Hirsch; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are diseases for which current therapies are only partially effective and are associated with significant side effects...
- PROSPECTIVE STUDY OF OSTEOPOROSIS & RISK FACTORS IN JRAC Rabinovich; Fiscal Year: 2000The long-term goal of this proposal is to reduce the risk for osteopenia and fracture in patients with juvenile rheumatoid arthritis (JRA)...
- LIVER NATURAL KILLER & ACCESSORY CELLS IN MURINE LUPUSDaniel Magilavy; Fiscal Year: 1992..accessory cells of the autoimmune strains? The results of these experiments may help in our understanding of immunoregulation and the autoimmune process in such disease as Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus.
- HLA GENES & HYBRID MOLECULES IN PAUCIARTICULAR JRABARBARA NEPOM; Fiscal Year: 1991Pauciarticular juvenile rheumatoid arthritis Type I (Pauci I JRA) is a relatively common inflammatory disease of childhood which, like a large number of "autoimmune" diseases, is associated with certain HLA Class II specificities...
- SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITISCarol Landis; Fiscal Year: 2006..applicant): Approximately 285,000 of America's children have been diagnosed with arthritis, and juvenile rheumatoid arthritis (JRA) is the most prevalent form...
- Development of molecular diagnostic assays for systemic autoimmune diseasesPETER KULAKOSKY; Fiscal Year: 2006..Subsequently we found evidence indicating that HIAP is also involved in the development of juvenile rheumatoid arthritis, systemic lupus erythematosus, and Grave's disease...
- PAUCI JRA SYNOVIAL CYTOKINESDavid Glass; Fiscal Year: 2002..that cytokines have a role in differentiating between the various clinical phenotypes that comprise juvenile rheumatoid arthritis (JRA), the commonest autoimmune rheumatic disease of childhood...
- ONSET AND PROGRESSION OF PUBERTYJean Wilson; Fiscal Year: 1980..3. Patients with juvenile rheumatoid arthritis - to determine the effect of J.R.A. on growth and development. 4...
- Leukocyte Microarrays in Juvenile Rheumatoid ArthritisJames Jarvis; Fiscal Year: 2003b>Juvenile rheumatoid arthritis (JRA) is a family of illnesses characterized by chronic inflammation and hyperplasia of the synovial linings of joints...
- TRAINING IN CLINICAL IMMUNOLOGYDennis Carson; Fiscal Year: 2000..therapy; (6) control of immune responses by gene therapeutics; and (7) pathogenesis of juvenile rheumatoid arthritis. The research of the staff preceptors is dedicated to the elucidation of the fundamental pathogenic ..
- The Functional Muscle-Bone Unit in JRAJon Burnham; Fiscal Year: 2009..training in clinical epidemiology and a research focus on the musculoskeletal complications of juvenile rheumatoid arthritis (JRA)...
- Early Aggressive Treatment of Polyarticular JRACarol Wallace; Fiscal Year: 2001..functional ability and health related quality of life outcomes of children with poly articular juvenile rheumatoid arthritis (poly-JRA)...
- CLINICAL TRAILS IN PEDIATRIC RHEUMATOLOGYDaniel Lovell; Fiscal Year: 2004..application is focused on the performance of two prospective, multicentered trials in children with juvenile rheumatoid arthritis (JRA)...
- Dynamics of Therapeutic Response Within the TREAT TrialJames N Jarvis; Fiscal Year: 2010....
- TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUSHermine Brunner; Fiscal Year: 2007..Abstract Not Provided ..
- Immune Tolerance after Severe Immunosuppression and Stem Cell Rescue for JIAYukiko Kimura; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Electronic Diary Assessment of Pain in Juvenile ArthritisLaura E Schanberg; Fiscal Year: 2010..Finally, the study can serve as a catalyst for future research aimed at advancing medical and psychological knowledge of pain in other pediatric medical populations. ..
- GENES SPECIFIC TO B CELL GERMINAL CENTER REACTIONSMaria Pascual; Fiscal Year: 2002..These studies may help reaching a better understanding of the connections between the processes of normal B cell differentiation and the development of germinal center malignancies. ..
- Headstrong Intervention for Recurrent Pediatric HeadacheMichael Rapoff; Fiscal Year: 2008..The primary study outcome will be headache_ frequency, duration, and intensity as measured by daily headache diaries. Secondary endpoints will include ,headache-related disability outcomes and quality of life. _ ..... ..
- Genetic variation in T-cell regulatory molecules and JRASampath Prahalad; Fiscal Year: 2008b>Juvenile rheumatoid arthritis (JRA) is one of the most common chronic conditions of children affecting approximately 50,000 children in the U.S...
- TNF Alpha In InflammationKathleen Sullivan; Fiscal Year: 2008..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. [unreadable] [unreadable]..
- ECTOPIC GERMINAL CENTER REACTION IN SYSTEMIC LUPUSMaria Pascual; Fiscal Year: 2004..3. To identify the + _ nature and function of the SLE-restricted CD19- CD20- cell populations that co-purify with B cells. 4. To determine the clinical relevance of the + _ accumulation f IgD+ CD38+ B cells and/or CD19- CD20- cells. ..
- Visual outcomes & quality of life in CMV retinitisJennifer Thorne; Fiscal Year: 2006..abstract_text> ..
- Immune Complex Stimulation of TNFalphaKathleen Sullivan; Fiscal Year: 2007..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
- Tobacco Control Strategies for Medically At-Risk YouthVida Tyc; Fiscal Year: 2005..Working Group manuscripts that correspond to each objective will be published as a supplement to the journal, Pediatrics. ..
- GENETIC DISSECTION OF A BONE DYSPLASIA/CANCER SYNDROMEJohn Martignetti; Fiscal Year: 2002....
- Genomic Landscapes in Large Scale Integrated JRA StudiesSusan Thompson; Fiscal Year: 2006b>Juvenile Rheumatoid Arthritis (JRA) is a heterogeneous group o f chronic pediatric arthropathies that a reinfluenced by a complex genetic trait and environmental factors...
- Cytokine Regulation of Liver Growth Hormone SignalingLee Denson; Fiscal Year: 2004..These findings will have implications for therapeutic strategies to ameliorate acquired GH resistance in diseases complicated by liver inflammation, including chronic cholestatic liver diseases ..
- C-X-C Chemokines and Kaposi's SarcomaDAVID MARKOVITZ; Fiscal Year: 2005..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
- Imaging Enzyme Structure and Dynamics: Specific Function and Functional DiversityHua Deng; Fiscal Year: 2010..The fruits of this work can lead to more thoroughly understanding disease and then to the discovery of new drugs and methods as well as laboratory diagnostic methods. ..
- Sensible Treatment of Obesity in Rural Youth- STORYDavid Janicke; Fiscal Year: 2006..Findings will provide critical information for planning the R18 RCT. ..
- Extended Psychosocial Analysis of PHONE Study DataJaneen Manuel; Fiscal Year: 2003..abstract_text> ..
- REGULATION OF HIV2 TRANSCRIPTION AND REPLICATIONDAVID MARKOVITZ; Fiscal Year: 2002..GLI-2/THP, a member of the GLI protooncogene family and DEK, previously associated with leukemia and juvenile rheumatoid arthritis, which we have shown to be a site-specific DNA-binding protein which mediates signal transduction ..
- CXC Chemokines and HIV PathogenesisDAVID MARKOVITZ; Fiscal Year: 2009..A mechanistic understanding of the interactions between HIV and these C-X-C chemokines could lead to the development of new approaches to the treatment of patients infected with HIV. ..
- Ontogeny of Drug Bioactivation and Idiosyncratic ADRsJAMES LEEDER; Fiscal Year: 2007..abstract_text> ..
- VIBRATIONAL AND DYNAMICAL STUDIES OF ENZYMESRobert Callender; Fiscal Year: 2002....
- Association of 7q22..1 gene VGF with obesity & leannessJohn Martignetti; Fiscal Year: 2008..These physiologically linked, target-tissue genes may themselves play a functional role in obesity resistance or susceptibility, and thus become excellent candidates for future investigation. ..
- Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical PriStuart Goodman; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Reduction of ETS Exposure in Pediatric Cancer PatientsVida Tyc; Fiscal Year: 2006..Our planned clinical trial may verify the effectiveness of an important clinical service for this vulnerable population that can be adapted for other pediatric oncology settings. ..