juvenile rheumatoid arthritis

Summary

Summary: Rheumatoid arthritis of children occurring in three major subtypes defined by the symptoms present during the first six months following onset: systemic-onset (Still's Disease, Juvenile-Onset), polyarticular-onset, and pauciarticular-onset. Adult-onset cases of Still's disease (STILL'S DISEASE, ADULT-ONSET) are also known. Only one subtype of juvenile rheumatoid arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

Top Publications

  1. ncbi Juvenile idiopathic arthritis
    Angelo Ravelli
    Department of Paediatrics, University of Genoa and Institute G Gaslini, Genoa, Italy
    Lancet 369:767-78. 2007
  2. ncbi Juvenile rheumatoid arthritis of the knee: evaluation with US
    D Sureda
    Department of Radiology, Ciutat Sanitària i Universitària Vall d Hebron, Autonomous University of Barcelona, Spain
    Radiology 190:403-6. 1994
  3. ncbi Bartonella infection associated with systemic juvenile rheumatoid arthritis
    M Tsukahara
    Faculty of Health Sciences, Yamaguchi University School of Medicine, Ube City, Japan
    Clin Infect Dis 32:E22-3. 2001
  4. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001
  5. ncbi International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001
    Ross E Petty
    Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    J Rheumatol 31:390-2. 2004
  6. ncbi Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis
    Carol A Wallace
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105, USA
    J Rheumatol 31:2290-4. 2004
  7. ncbi A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate
    Nicolino Ruperto
    IRCCS G Gaslini, University of Genoa, Genoa, Italy
    Arthritis Rheum 50:2191-201. 2004
  8. ncbi A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis
    Nicolino Ruperto
    IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3096-106. 2007
  9. ncbi Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis
    James W Verbsky
    Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Lousis Children s Hospital, Missouri 63110, USA
    J Rheumatol 31:2071-5. 2004
  10. ncbi Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA Registry
    G Horneff
    Department of Paediatrics, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany
    Ann Rheum Dis 68:519-25. 2009

Detail Information

Publications278 found, 100 shown here

  1. ncbi Juvenile idiopathic arthritis
    Angelo Ravelli
    Department of Paediatrics, University of Genoa and Institute G Gaslini, Genoa, Italy
    Lancet 369:767-78. 2007
    ....
  2. ncbi Juvenile rheumatoid arthritis of the knee: evaluation with US
    D Sureda
    Department of Radiology, Ciutat Sanitària i Universitària Vall d Hebron, Autonomous University of Barcelona, Spain
    Radiology 190:403-6. 1994
    To evaluate the value of ultrasound (US) in assessing joint inflammation in patients with juvenile rheumatoid arthritis (JRA) of the knee.
  3. ncbi Bartonella infection associated with systemic juvenile rheumatoid arthritis
    M Tsukahara
    Faculty of Health Sciences, Yamaguchi University School of Medicine, Ube City, Japan
    Clin Infect Dis 32:E22-3. 2001
    A 4-year-old girl with systemic juvenile rheumatoid arthritis had Bartonella infection diagnosed serologically...
  4. ncbi A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    R P Donn
    Epidemiology Unit, Arthritis Research Campaign, Manchester, UK
    Arthritis Rheum 44:1782-5. 2001
    ..To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA)...
  5. ncbi International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001
    Ross E Petty
    Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    J Rheumatol 31:390-2. 2004
  6. ncbi Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis
    Carol A Wallace
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105, USA
    J Rheumatol 31:2290-4. 2004
    ..To develop preliminary criteria for inactive disease and clinical remission for select categories of juvenile idiopathic arthritis (JIA), and to decide what such clinical states should predict in terms of probability of disease recurrence...
  7. ncbi A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate
    Nicolino Ruperto
    IRCCS G Gaslini, University of Genoa, Genoa, Italy
    Arthritis Rheum 50:2191-201. 2004
    ..5 mg/m(2)/week)...
  8. ncbi A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis
    Nicolino Ruperto
    IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3096-106. 2007
    To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA).
  9. ncbi Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis
    James W Verbsky
    Division of Rheumatology, Department of Pediatrics, Washington University School of Medicine, St Lousis Children s Hospital, Missouri 63110, USA
    J Rheumatol 31:2071-5. 2004
    Systemic onset juvenile rheumatoid arthritis (SOJRA) is a multisystem disease characterized by high fever, rash, arthritis, serositis, splenomegaly, and laboratory evidence of systemic inflammation...
  10. ncbi Safety and efficacy of combination of etanercept and methotrexate compared to treatment with etanercept only in patients with juvenile idiopathic arthritis (JIA): preliminary data from the German JIA Registry
    G Horneff
    Department of Paediatrics, Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany
    Ann Rheum Dis 68:519-25. 2009
    ..The following study evaluates the safety and efficacy of combination therapy of etanercept and methotrexate compared to etanercept monotherapy in JIA...
  11. ncbi Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 35:343-8. 2008
    To characterize the initial clinical and laboratory features of patients with systemic onset juvenile rheumatoid arthritis (soJRA) through a Web-based registry.
  12. ncbi Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis
    Christian Huemer
    Department of Pediatrics, University of Vienna, Austria
    J Rheumatol 29:1531-5. 2002
    ..patients with oligoarticular onset juvenile psoriatic arthritis (Oligo-JPsA) and pauciarticular onset juvenile rheumatoid arthritis (Pauci-JRA) in order to estimate the predictive performance of specific patterns for the diagnosis of ..
  13. ncbi Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis
    Amita Aggarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014
    Rheumatol Int 23:134-7. 2003
    ..MTX) is one of the most widely used disease-modifying antirheumatoid drugs in the treatment of juvenile rheumatoid arthritis (JRA)...
  14. ncbi Macrophage activation syndrome
    Angelo Ravelli
    Pediatria II, Istituto G Gaslini, Universita di Genova, Italy
    Curr Opin Rheumatol 14:548-52. 2002
    ..Cyclosporin A has been found effective in patients with corticosteroid-resistant MAS. A recent report has suggested that etanercept may be a useful adjunctive therapeutic agent...
  15. ncbi Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I
    Charles G Helmick
    CDC, Atlanta, Georgia 30341 3717, USA
    Arthritis Rheum 58:15-25. 2008
    ..A companion article (part II) addresses additional conditions...
  16. ncbi Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population
    Silvia Jiménez-Morales
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
    Hum Immunol 70:251-6. 2009
    ..238G/A TNF-alpha polymorphisms were associated with asthma, systemic lupus erythematosus (SLE), and juvenile rheumatoid arthritis (JRA) in a pediatric Mexican population...
  17. ncbi Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?
    Seza Ozen
    Department of Pediatrics, Hacettepe University, 06100 Ankara, Turkey
    J Rheumatol 30:2014-8. 2003
    ..We also prospectively evaluated 72 patients with childhood rheumatic diseases for the presence of MEFV mutations...
  18. ncbi Medical treatment of juvenile idiopathic arthritis
    Philip J Hashkes
    Section of Pediatric Rheumatology, Department of Rheumatic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 294:1671-84. 2005
    ..The treatment of juvenile idiopathic arthritis (JIA) has changed markedly in the last 15 years. Many children with JIA are not treated by pediatric rheumatologists...
  19. ncbi Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type
    Pierre Quartier
    Hopital Necker Enfants Malades, Paris, France
    Arthritis Rheum 48:1093-101. 2003
    ..To assess the efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA), and to assess the tolerance of these patients to etanercept...
  20. ncbi Incidence and outcomes of uveitis in juvenile rheumatoid arthritis, a synthesis of the literature
    Petros E Carvounis
    Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Graefes Arch Clin Exp Ophthalmol 244:281-90. 2006
    b>Juvenile rheumatoid arthritis (JRA) is the most common systemic cause of pediatric uveitis in Europe and North America...
  21. ncbi Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis
    Jocelyn Sicat
    Department of Rheumatology, Tufts New England Medical Center, Boston, Massachusetts, USA
    J Rheumatol 32:1821-31. 2005
    ..We measured the expression and the ability of interferon-alpha (IFN-alpha) to induce the human endogenous retrovirus HERV-K18 superantigen in juvenile rheumatoid arthritis (JRA) and pediatric systemic lupus erythematosus (SLE).
  22. ncbi Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathy
    K Nistala
    Paediatric Rheumatology Unit, Great Ormond Street Hospital, London, England
    J Rheumatol 28:2125-8. 2001
    We describe 2 pediatric patients with sickle cell disease (SCD) who developed seropositive juvenile rheumatoid arthritis (JRA). Both patients have severe joint damage, the compound effect of both disease processes...
  23. ncbi Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritis
    B D Carter
    University of Louisville School of Medicine, Louisville, Kentucky, USA
    Pediatrics 103:975-9. 1999
    ..To determine if psychological morbidity in youth with chronic fatigue is caused by the stress of coping with a chronic illness...
  24. ncbi Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
    Angelo Ravelli
    Department of Pediatrics, Division of Pediatrics II, University of Genoa, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    J Pediatr 146:598-604. 2005
    ..To develop diagnostic guidelines for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (S-JIA)...
  25. ncbi Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis
    Cristina Meazza
    University of Pavia, IRCCS Policlinico San Matteo, Italy
    Arthritis Rheum 46:232-7. 2002
    ..To evaluate serum and synovial fluid (SF) levels of macrophage migration inhibitory factor (MIF) and in vitro MIF production by peripheral blood mononuclear cells (PBMCs) in patients with juvenile idiopathic arthritis (JIA)...
  26. ncbi Different familial association patterns of autoimmune diseases between juvenile-onset systemic lupus erythematosus and juvenile rheumatoid arthritis
    Chun mei Huang
    Department of Pediatrics, National Taiwan University Hospital, No 7 Chung Shan South Road, Taipei, Taiwan 100, ROC
    J Microbiol Immunol Infect 37:88-94. 2004
    ..of patients with systemic lupus erythematosus (SLE) is greater than that of relatives of patients with juvenile rheumatoid arthritis (JRA)...
  27. pmc Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis
    David C Wilson
    Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA
    Arthritis Rheum 62:2510-6. 2010
    To examine both the source of follistatin-like protein 1 (FSTL-1) and the factors that induce its expression in arthritis, and to determine whether juvenile rheumatoid arthritis (JRA) is characterized by overexpression of FSTL-1.
  28. ncbi Role of power Doppler sonography in evaluation of therapeutic response of the knee in juvenile rheumatoid arthritis
    C Shanmugavel
    Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh 160012, India
    Rheumatol Int 28:573-8. 2008
    ..is to study the role of power Doppler sonography (PDS) in assessment of therapeutic response in juvenile rheumatoid arthritis (JRA) of knee joint...
  29. ncbi Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al
    Nobuaki Maeno
    Arthritis Rheum 46:2539-41; author reply 2541-2. 2002
  30. ncbi The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    Jack Bleesing
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:965-71. 2007
    ..This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA)...
  31. pmc Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
    N M Wulffraat
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 62:236-41. 2003
    ....
  32. ncbi Tumour necrosis factor alpha G-->A -238 and G-->A -308 polymorphisms in juvenile idiopathic arthritis
    S Ozen
    Department of Paediatric Nephrology and Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Rheumatology (Oxford) 41:223-7. 2002
    ..We analysed whether there were any associations between these polymorphisms and the type of JIA and/or the clinical course of the disease in two populations...
  33. ncbi The British version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)
    J Nugent
    Institute of Child Health, University College, London, United Kingdom
    Clin Exp Rheumatol 19:S163-7. 2001
    ..In conclusion the British version of the CHAQ-CHQ is a reliable, and valid tool for the functional, physical and psychosocial assessment of children with JIA...
  34. ncbi Prevention of nonadherence to nonsteroidal anti-inflammatory medications for newly diagnosed patients with juvenile rheumatoid arthritis
    Michael A Rapoff
    Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160 7330, USA
    Health Psychol 21:620-3. 2002
    ..the anticipated drop in adherence to nonsteroidal medications among newly diagnosed patients with juvenile rheumatoid arthritis. Thirty-four participants completed the study (mean age = 8.44 years, SD = 3...
  35. ncbi Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodology
    N Ruperto
    Laboratorio di Informatica Medica, IRCCS San Matteo, University of Pavia, Pavia, Italy
    Clin Exp Rheumatol 19:S1-9. 2001
    ..The results of the present study show that cross-cultural adaptation is a valid process to obtain reliable instruments for the different socio-economic and socio-demographic conditions of the countries participating in the project...
  36. ncbi Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study
    Norman Ilowite
    Schneider Children s Hospital, New Hyde Park, NY 10467, USA
    Clin Rheumatol 28:129-37. 2009
    ..efficacy of the interleukin-1 receptor antagonist anakinra in patients with polyarticular-course juvenile rheumatoid arthritis (JRA)...
  37. ncbi Gastrointestinal symptoms and their association with health-related quality of life of children with juvenile rheumatoid arthritis: validation of a gastrointestinal symptom questionnaire
    Hermine I Brunner
    Division of Rheumatology E 4010, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Clin Rheumatol 11:194-204. 2005
    ..perform an initial validation of the Gastrointestinal Symptom Scale for Kids (GISSK) in children with juvenile rheumatoid arthritis (JRA); and too evaluate the relationship between gastrointestinal (GI) symptoms and health-related ..
  38. ncbi Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study
    N J Peake
    Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Rheumatology (Oxford) 44:1383-9. 2005
    ....
  39. pmc The German etanercept registry for treatment of juvenile idiopathic arthritis
    G Horneff
    Department of Paediatrics, University Medical Centre, Martin Luther University, Halle Wittenberg, Germany
    Ann Rheum Dis 63:1638-44. 2004
    ..To describe a registry set up to monitor children treated with etanercept in Germany and Austria...
  40. ncbi Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France
    T Lequerre
    Rheumatology Department, Rouen University Hospital and Inserm 905, 76031 Rouen, France
    Ann Rheum Dis 67:302-8. 2008
    ..Anakinra treatment has been reported to be effective in some patients with systemic-onset juvenile idiopathic arthritis (SoJIA) or adult-onset Still disease (AoSD)...
  41. ncbi The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families
    Emma M Ogilvie
    University College London, London, UK
    Arthritis Rheum 48:3202-6. 2003
    ..The present study was undertaken to confirm the previous findings and to assess possible association with variations of the A(n)T(n) tract in the promoter...
  42. ncbi Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis
    Elena M O Felin
    University of Utah, Salt Lake City, UT 84158, USA
    Arthritis Rheum 56:984-94. 2007
    ..computed tomography (pQCT), compared with general bone characteristics as measured using dual x-ray absorptiometry (DXA), and to assess their relationship to disease-related factors in children with juvenile rheumatoid arthritis (JRA).
  43. ncbi Increased prevalence of familial autoimmunity in simplex and multiplex families with juvenile rheumatoid arthritis
    Sampath Prahalad
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132, USA
    Arthritis Rheum 46:1851-6. 2002
    To determine if the prevalence of autoimmunity among relatives of patients with juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer control subjects.
  44. pmc A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis
    A B Begovich
    Department of Human Genetics, Cetus Corporation, Emeryville, CA 94608
    Proc Natl Acad Sci U S A 86:9489-93. 1989
    ..format to type samples amplified by the polymerase chain reaction from 44 patients with pauciarticular juvenile rheumatoid arthritis, 32 patients with adult rheumatoid arthritis, and 50 random controls...
  45. pmc Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    Florence Allantaz
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Exp Med 204:2131-44. 2007
    ..Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities...
  46. pmc Arthrosonography of hip and knee joints in the follow up of juvenile rheumatoid arthritis
    M Frosch
    Department of Paediatrics, University of Muenster, Albert Schweitzer Str 33, D 48149 Muenster, Germany
    Ann Rheum Dis 62:242-4. 2003
    To evaluate sensitivity of arthrosonography of hip and knee joints for monitoring disease activity in juvenile rheumatoid arthritis (JRA).
  47. pmc Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA)
    A Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Exp Immunol 148:515-9. 2007
    ..05). TARC/CCL17 levels in SF were lower than serum. There is increased homing of CCR5 and CXCR3(+) CD4 cells to the SF. Increased SF levels of IP-10/CXCL10 may be responsible for this migration in patients with ERA...
  48. ncbi Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study
    Thomas J A Lehman
    Division of Pediatric Rheumatology, Hospital for Special Surgery, and the Department of Pediatrics, Sanford Weill Medical College of Cornell University, New York, New York, USA
    J Pediatr 145:856-7. 2004
    Thirteen children with difficult systemic onset juvenile rheumatoid arthritis were treated with thalidomide. At 6 months, 11 of the 13 were able to reduce their use of prednisone ( P < ...
  49. ncbi Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations
    Dirk Foell
    Institute of Experimental Dermatology and Department of Pediatrics, University of Muenster, Muenster, Germany
    Arthritis Rheum 50:1286-95. 2004
    ..The aim of our study was to determine neutrophil activation in juvenile rheumatoid arthritis (JRA) by analyzing S100A12 (EN-RAGE; calgranulin C), a proinflammatory protein secreted by human ..
  50. ncbi Sleep quality in children with juvenile rheumatoid arthritis
    Susan E Labyak
    Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle 98195 7262, USA
    Holist Nurs Pract 17:193-200. 2003
    Children with juvenile rheumatoid arthritis (JRA) report poor sleep quality, daytime sleepiness, fatigue, anxiety, and altered mood. Sleep disturbances in school-aged children are an issue of serious concern...
  51. ncbi Polysomnography and self-reported sleep, pain, fatigue, and anxiety in children with active and inactive juvenile rheumatoid arthritis
    Teresa M Ward
    Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, 98195 7266, USA
    J Pediatr Psychol 33:232-41. 2008
    To compare polysomnography (PSG) and self-reported sleep, symptoms (pain and fatigue), and anxiety between children with active and inactive juvenile rheumatoid arthritis (JRA) and examine relations among sleep, symptoms, and anxiety.
  52. ncbi Quantifying dynamic contrast-enhanced MRI of the knee in children with juvenile rheumatoid arthritis using an arterial input function (AIF) extracted from popliteal artery enhancement, and the effect of the choice of the AIF on the kinetic parameters
    Dagnachew W Workie
    Department of Physics, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Magn Reson Med 54:560-8. 2005
    ..This work deals with modeling of DCE-MRI data from the knees of children with a history of juvenile rheumatoid arthritis (JRA) by using an AIF extracted from the signal enhancement data from the nearby popliteal artery...
  53. ncbi Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    Ndate Fall
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:3793-804. 2007
    ..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...
  54. pmc Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
    Koert M Dolman
    Department of Pediatric Hematology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, 1105 AZ, The Netherlands
    Arthritis Res Ther 10:R32. 2008
    ..The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis (JRA) and whether MBL2 genotypes are associated with JRA severity.
  55. ncbi Factors associated with the use of complementary and alternative medicine in juvenile idiopathic arthritis
    Debbie Ehrmann Feldman
    Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 51:527-32. 2004
    ....
  56. ncbi Prognostic factors in juvenile rheumatoid arthritis: a case-control study revealing early predictors and outcome after 14.9 years
    Berit Flatø
    Center for Rheumatic Diseases, Rikshospitalet University Hospital, Oslo, Norway
    J Rheumatol 30:386-93. 2003
    To describe the physical and psychosocial outcome in patients with juvenile rheumatoid arthritis (JRA), compared with subjects in the general population, and to determine patient characteristics, HLA alleles, and disease variables within ..
  57. ncbi Growth patterns in juvenile rheumatoid arthritis
    J J Liem
    Section of Rheumatology, Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada
    Clin Exp Rheumatol 21:663-8. 2003
    To define patterns of growth in juvenile rheumatoid arthritis (JRA) and to evaluate possible associated clinical and laboratory correlates.
  58. pmc Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    Claudia R Ruprecht
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 201:1793-803. 2005
    ....
  59. ncbi A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritis
    Jennifer Reiter-Purtill
    Division of Hematology Oncology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
    J Pediatr Psychol 28:17-28. 2003
    To complete an assessment of social functioning of children with juvenile rheumatoid arthritis (JRA) and nonchronically ill controls who had been evaluated 2 years earlier (Noll et al...
  60. ncbi Toward an understanding of the long-term outcome of juvenile idiopathic arthritis
    A Ravelli
    Clin Exp Rheumatol 22:271-5. 2004
    ....
  61. ncbi Worldwide prevalence of juvenile arthritis why does it vary so much?
    Prudence Joan Manners
    Department of Paediatrics, University of Western Australia, Perth, Australia
    J Rheumatol 29:1520-30. 2002
    ..JA is the term used here collectively for juvenile rheumatoid arthritis, juvenile chronic arthritis, or juvenile idiopathic arthritis as defined in the respective published ..
  62. ncbi Comparative epidemiology of the rheumatic diseases in children
    K Oen
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Curr Opin Rheumatol 12:410-4. 2000
    ..Other publications during the past year have updated the epidemiology of Kawasaki disease, Behcet disease, and acute rheumatic fever...
  63. ncbi The clinical meaning of functional outcome scores in children with juvenile arthritis
    H Dempster
    University of Toronto, Ontario, Canada
    Arthritis Rheum 44:1768-74. 2001
    ..CONCLUSION: Clinicians, as well as researchers setting protocols, should aim for a mimimum improvement of 0.13 in the CHAQ score when treating pediatric patients with arthritis...
  64. ncbi A case-control sleep study in children with polyarticular juvenile rheumatoid arthritis
    Cassia M Passarelli
    Department of Pediatrics, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    J Rheumatol 33:796-802. 2006
    To investigate the relationship between clinical manifestations and sleep abnormalities in patients with juvenile rheumatoid arthritis (JRA).
  65. ncbi A prospective study comparing celecoxib with naproxen in children with juvenile rheumatoid arthritis
    Ivan Foeldvari
    Hamburger Zentrum für Kinder und Jugendrheumatologie, am Klinikum Eilbek, Dehnhaide 120, 22081 Hamburg, Germany
    J Rheumatol 36:174-82. 2009
    To compare the efficacy and safety of celecoxib and naproxen in children with juvenile rheumatoid arthritis (JRA).
  66. ncbi Electronically monitored adherence to medications by newly diagnosed patients with juvenile rheumatoid arthritis
    Michael A Rapoff
    University of Kansas Medical Center, Kansas City, KS 66160 7330, USA
    Arthritis Rheum 53:905-10. 2005
    ..patterns of adherence to nonsteroidal antiinflammatory drugs (NSAIDs) in newly diagnosed patients with juvenile rheumatoid arthritis (JRA), and to examine demographic and disease-related variables as potential predictors of adherence.
  67. ncbi Adalimumab with or without methotrexate in juvenile rheumatoid arthritis
    Daniel J Lovell
    Cincinnati Children s Hospital Medical Center, Division of Rheumatology, Location E, Rm 2 129, MLC 4010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    N Engl J Med 359:810-20. 2008
    Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF antibody, in children with polyarticular-course juvenile rheumatoid ..
  68. ncbi The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis
    Berit Flatø
    Center for Rheumatic Diseases, Rikshospitalet University Hospital, Oslo, Norway
    Arthritis Rheum 46:986-94. 2002
    ....
  69. ncbi Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis
    Rebecca Lamb
    Arthritis Research Campaign Epidemiology Unit and Centre for Molecular Medicine, University of Manchester, Manchester, UK
    Arthritis Rheum 56:1286-91. 2007
    ..To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA)...
  70. ncbi Brief report: use of complementary and alternative medicine and psychological functioning in Latino children with juvenile idiopathic arthritis or arthralgia
    Kathy Zebracki
    Loyola University Chicago, Department of Psychology, IL 60626, USA
    J Pediatr Psychol 32:1006-10. 2007
    ..To describe the use of complementary and alternative medicine (CAM) and its relationship to symptoms of anxiety, depression, and dysthymia in Latino children with juvenile idiopathic arthritis (JIA) or arthralgia...
  71. ncbi Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis
    Christine R Culy
    Adis International Limited, Auckland, New Zealand
    Drugs 62:2493-537. 2002
    ..In patients with polyarticular-course juvenile rheumatoid arthritis, etanercept resulted in improvements in all measures of disease activity and was significantly more ..
  72. ncbi Juvenile rheumatoid arthritis: physical therapy and rehabilitation
    Aysegul Cakmak
    Department of Physical Medicine and Rehabilitation, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    South Med J 98:212-6. 2005
    ..This article summarizes the objectives and methods of physical therapy and rehabilitation that are important parts of treatment...
  73. ncbi Adenosine deaminase activity and its isoenzyme pattern in patients with juvenile rheumatoid arthritis and systemic lupus erythematosus
    S Hitoglou
    Aristotle University of Thessaloniki, Greece
    Clin Rheumatol 20:411-6. 2001
    ..and its isoenzymes ADA1 and ADA2 in serum and peripheral blood lymphocytes (PBLs) of children with juvenile rheumatoid arthritis (JRA) and systemic lupus erythematosus (SLE) in different phases of the diseases...
  74. ncbi Juvenile idiopathic arthritis: an update
    Judyann C Olson
    Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, Wis, USA
    WMJ 102:45-50. 2003
    ..Previous terminology identified this entity as juvenile rheumatoid arthritis. The 7 subsets of JIA identified under the new classification system are discussed, as are current ..
  75. ncbi Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthma
    A Heinzmann
    University Children s Hospital, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Allergy 59:845-9. 2004
    ..Our interest was to test polymorphisms of IL-18 for association with a typical TH1-mediated disease--juvenile idiopathic arthritis--and the TH2-mediated disease bronchial asthma in Caucasian children...
  76. ncbi Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis
    Bradley J Bloom
    Department of Pediatrics, Hasbro Children s Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    J Rheumatol 29:169-73. 2002
    To determine what sleep abnormalities may exist in children with juvenile rheumatoid arthritis (JRA). and their relationship to pain, dysfunction. and disease activity.
  77. ncbi Total knee replacement in juvenile rheumatoid arthritis
    David E Rojer
    Dept of Orthopedic Surgery, Stanford University Medical Center 300 Pasteur Dr, Stanford, CA 94305, USA
    Orthopedics 28:39-45; quiz 46-7. 2005
    ..times and in some cases increased blood requirements can be expected with TKA in patients with juvenile rheumatoid arthritis. Complications also are more frequent...
  78. ncbi Comparing parental distress, family functioning, and the role of social support for caregivers with and without a child with juvenile rheumatoid arthritis
    Cynthia A Gerhardt
    Division of Hematology Oncology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
    J Pediatr Psychol 28:5-15. 2003
    To assess parental distress, family functioning, and social support among parents of children with a lifetime diagnosis of juvenile rheumatoid arthritis (JRA) and comparison families.
  79. ncbi Lowered IL-4-producing T cells and decreased IL-4 secretion in peripheral blood from subjects with juvenile rheumatoid arthritis
    J L Huang
    Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan, R O C
    Chang Gung Med J 24:77-83. 2001
    To evaluate T helper 1 (Th1)/Th2 cells and cytokines in patients with three different subtypes of juvenile rheumatoid arthritis (JRA).
  80. ncbi Factors affecting clinical and therapeutic outcomes of patients with juvenile rheumatoid arthritis
    C T Hsu
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China
    Scand J Rheumatol 33:312-7. 2004
    To investigate clinical features, medications, and therapeutic responses of juvenile rheumatoid arthritis (JRA) among Taiwanese children.
  81. ncbi Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritis
    B B Bharti
    Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Postgrad Med 50:262-5; discussion 266-7. 2004
    ..echocardiographic studies of Left ventricular (LV) systolic and diastolic function in patients with juvenile rheumatoid arthritis (JRA), a study was carried out to study these parameters in these subjects...
  82. ncbi An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis
    K L Rupert
    Children s Hospital Research Foundation, Columbus, Ohio, USA
    Exp Clin Immunogenet 16:81-97. 1999
    ..polymorphism (RFLP) analysis was utilized to determine the RCCX modular variation in patients with juvenile rheumatoid arthritis (JRA)...
  83. ncbi Measuring the function of children with juvenile arthritis
    A Tennant
    Rheumatology and Rehabilitation Research Unit, School of Medicine, The University of Leeds, Leeds, UK
    Rheumatology (Oxford) 40:1274-8. 2001
    ..Most showed poor levels of unidimensionality. CONCLUSION: Until new measures become available, the CHAQ appears to be the current 'best buy' for measuring function in children with arthritis...
  84. ncbi Coexistent sickle cell disease and juvenile rheumatoid arthritis: 2 cases with delayed diagnosis and severe destructive arthropathy
    B Anne Eberhard
    J Rheumatol 29:1802; author reply 1802-3. 2002
  85. ncbi Care of the adult with juvenile rheumatoid arthritis
    Peter A Nigrovic
    Center for Adults with Pediatric Rheumatic Illness, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, One Jimmy Fund Way, Smith 356, Boston, MA 02115, USA
    Arthritis Rheum 55:208-16. 2006
  86. ncbi Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity
    Hanaa Mahmoud El Awady
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Pak J Biol Sci 10:1471-6. 2007
    ..was conducted to investigate the abnormalities in early morning serum melatonin among patients with Juvenile Rheumatoid Arthritis (JRA) and to outline its relation to disease activity and severity...
  87. ncbi Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis
    Tsung Chieh Yao
    Chang Gung Memorial Hospital, Chang Gung Children s Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan
    Arthritis Rheum 60:1173-8. 2009
    We recently reported that RANTES was a key molecule in the pathogenesis of juvenile rheumatoid arthritis (JRA) in a longitudinal cohort...
  88. ncbi Systemic juvenile rheumatoid arthritis: cognitive function and social adjustment
    Reinhold Feldmann
    Department of Pediatrics, University Hospital of Munster, Munster, Germany
    Ann Neurol 58:605-9. 2005
    ..exist that focus on possible long-term risks for central nervous system involvement in systemic juvenile rheumatoid arthritis (SJRA). We investigated 31 children and adolescents with SJRA, aged 6 to 24 years (mean, 12...
  89. ncbi Renal involvement in juvenile rheumatoid arthritis: report of two cases
    A Gedalia
    Department of Pediatrics, LSU Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
    Clin Rheumatol 20:153-6. 2001
    Renal involvement is a rare occurrence in juvenile rheumatoid arthritis (JRA). We report on two JRA patients with kidney disease. The first was a 14-year-old African-American female with a 12-month history of polyarthritis...
  90. ncbi Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
    Shumpei Yokota
    Department of Paediatrics, Yokohama City University School of Medicine, Yokohama, Japan
    Lancet 371:998-1006. 2008
    ..We investigated the efficacy and safety of tocilizumab, an anti-interleukin-6-receptor monoclonal antibody, in children with this disorder...
  91. ncbi Novel IL-6 haplotypes and disease association
    M S Fife
    Pediatric and Adolescent Rheumatology, University College London, UK
    Genes Immun 6:367-70. 2005
    ..This suggests that the haplotype effect may be more functionally relevant to the disease...
  92. ncbi Etanercept in the treatment of macrophage activation syndrome
    S Prahalad
    Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio 45229-3039, USA
    J Rheumatol 28:2120-4. 2001
    Macrophage activation syndrome (MAS), a recognized complication of systemic juvenile rheumatoid arthritis (sJRA), has been associated with significant morbidity and mortality...
  93. ncbi Clinically diagnosed fatal cerebral vasculitis in long-standing juvenile rheumatoid arthritis
    Gabriella Kiss
    Virchows Arch 448:381-3. 2006
  94. ncbi Comparing the self-reported referral and management preferences of pediatricians and family physicians for children with juvenile rheumatoid arthritis
    Gary L Freed
    Child Health Evaluation and Research CHEAR Unit, Division of General Pediatrics, University of Michigan, 300 NIB 6E08, Ann Arbor, MI 48109 0456, USA
    J Rheumatol 30:2700-4. 2003
    The symptoms of juvenile rheumatoid arthritis (JRA) are often first recognized by primary care physicians. Little is known about the determinants of the initial management and referral patterns of these physicians for children with JRA...
  95. ncbi Nutritional status and clinical characteristics in children with juvenile rheumatoid arthritis
    Shou Ting Shin
    Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 43:93-8. 2010
    The aim of the study was to investigate the clinical characteristics and nutritional status of juvenile rheumatoid arthritis (JRA) in Taiwanese children.
  96. ncbi Juvenile rheumatoid arthritis
    F Falcini
    Department of Pediatric Rheumatology Unit, University of Florence, Faculty of Medicine, Firenze, Italy
    Curr Opin Rheumatol 12:415-9. 2000
    ..The immunopathogenesis of the diseases that are encompassed by the term juvenile rheumatoid arthritis is complex, and many studies have investigated the role of genetic and cytokine balance abnormalities...
  97. ncbi Surgical management of cataracts in children with juvenile rheumatoid arthritis-associated uveitis
    Linda A Lam
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Ophthalmol 135:772-8. 2003
    To evaluate outcomes of cataract surgery with posterior chamber intraocular lens (IOL) implantation with or without trabeculectomy in children with juvenile rheumatoid arthritis (JRA)-associated uveitis.
  98. ncbi Juvenile rheumatoid arthritis-like polyarthritis in Nijmegen breakage syndrome
    S D Rosenzweig
    Servicio de Inmunologia, Hospital Nacional de Pediatria J P Garrahan, Buenos Aires, Argentina
    J Rheumatol 28:2548-50. 2001
    ..girl with all the clinical, immunological, and cytogenic characteristics described for NBS plus a juvenile rheumatoid arthritis-like syndrome...
  99. ncbi [Dietetic and anthropometric assessment in juvenile rheumatoid arthritis patients]
    Daniela Maria Alves Chaud
    Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brasil
    Rev Assoc Med Bras 49:181-4. 2003
    to evaluate the dietary intake and the anthropometry of children and adolescents with juvenile rheumatoid arthritis - JRA, considering the pauciarticular and the polyarticular types.
  100. ncbi Risk and resistance factors in the adaptation in mothers of children with juvenile rheumatoid arthritis
    J C Manuel
    Wake Forest University School of Medicine, Department of Public Health Sciences, Winston Salem, North Carolina 27157, USA
    J Pediatr Psychol 26:237-46. 2001
    ..severity, child functional status, psychosocial stress, intrapersonal factors, stress processing, and social-ecological factors in predicting psychological symptoms among mothers of children with juvenile rheumatoid arthritis (JRA).
  101. pmc Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 201:1479-86. 2005
    ..We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease...

Research Grants62

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Behavioral Rx & Nutrition in Pediatric Chronic Disease
    Lori J Stark; Fiscal Year: 2010
    ..calcium has been equally effective in improving the calcium intake and bone accretion in children with juvenile rheumatoid arthritis and inflammatory bowel disease...
  3. Meso Scale Discovery Sector 6000 Imager
    CHARLES ALFRED STANLEY; Fiscal Year: 2010
    ..disease and renal transplantation, adolescent obesity, pediatric type 2 diabetes, cystic fibrosis, and juvenile rheumatoid arthritis. Overall, the multiplex immunoassay platform will expand our capacity to provide analysis of different ..
  4. Proteomic Profiles and Novel Biomarkers in Juvenile Rheumatoid Arthritis
    Margalit E Rosenkranz; Fiscal Year: 2010
    DESCRIPTION: (provided by applicant): Juvenile Rheumatoid Arthritis (JRA) comprises a heterogeneous group of childhood onset, chronic, autoimmune diseases with variable clinical presentations, outcomes and therapeutic responses...
  5. USE OF THERMAL AND 3D IMAGING TO QUANTIFY ARTHRITIS
    Raphael Hirsch; Fiscal Year: 2010
    ..by applicant): One of the biggest challenges in caring for patients with Rheumatoid Arthritis (RA) and Juvenile Rheumatoid Arthritis (JRA) is quantifying the degree of disease activity in any given joint...
  6. Kaiser Permanente Autoimmune Disease Registry
    Lisa J Herrinton; Fiscal Year: 2010
    ..Registry will include all members of KP Northern California with prevalent rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, and ankylosing spondylitis during the 15-year period 1996-2010...
  7. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Sophia Y Cleland; Fiscal Year: 2010
    ..eliminate health disparities by characterizing the genetic bases for rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) between ethnic groups...
  8. RESEARCH REGISTRY FOR JUVENILE RHEUMATOID ARTHRITIS
    Mark Haggard; Fiscal Year: 2009
    b>Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare...
  9. LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITIS
    Robert Colbert; Fiscal Year: 2001
    b>Juvenile rheumatoid arthritis (JRA) is a heterogeneous autoimmune disease likely to result from multiple genetic and environmental factors...
  10. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    MICHELLE URBAN; Fiscal Year: 1999
    ..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
  11. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    John McGuire; Fiscal Year: 2001
    ..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
  12. PULSE THERAPY IN SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS
    Daniel Lovell; Fiscal Year: 2000
    DESCRIPTION (adapted from applicant's abstract): Systemic juvenile rheumatoid arthritis (sJRA) is associated with significant long term morbidity and mortality...
  13. HLA-DP SEQUENCE POLYMORPHISM AND DISEASE PREDISPOSITION
    Henry Erlich; Fiscal Year: 2003
    ..We will focus on three diseases: pauciarticular juvenile rheumatoid arthritis, type 1 diabetes, and cervical carcinoma...
  14. Hepcidin Expression in the Anemia of Chronic Disease
    David Weinstein; Fiscal Year: 2007
    ..homeostasis and hepcidin expression will be studied in normal and pathologic states including GSD1a, juvenile rheumatoid arthritis, and inflammatory bowel disease...
  15. Adeno-Associated Virus-Mediated Synovial Gene Transfer
    Raphael Hirsch; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are diseases for which current therapies are only partially effective and are associated with significant side effects...
  16. PROSPECTIVE STUDY OF OSTEOPOROSIS & RISK FACTORS IN JRA
    C Rabinovich; Fiscal Year: 2000
    The long-term goal of this proposal is to reduce the risk for osteopenia and fracture in patients with juvenile rheumatoid arthritis (JRA)...
  17. LIVER NATURAL KILLER & ACCESSORY CELLS IN MURINE LUPUS
    Daniel Magilavy; Fiscal Year: 1992
    ..accessory cells of the autoimmune strains? The results of these experiments may help in our understanding of immunoregulation and the autoimmune process in such disease as Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus.
  18. HLA GENES & HYBRID MOLECULES IN PAUCIARTICULAR JRA
    BARBARA NEPOM; Fiscal Year: 1991
    Pauciarticular juvenile rheumatoid arthritis Type I (Pauci I JRA) is a relatively common inflammatory disease of childhood which, like a large number of "autoimmune" diseases, is associated with certain HLA Class II specificities...
  19. SLEEP IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS
    Carol Landis; Fiscal Year: 2006
    ..applicant): Approximately 285,000 of America's children have been diagnosed with arthritis, and juvenile rheumatoid arthritis (JRA) is the most prevalent form...
  20. Development of molecular diagnostic assays for systemic autoimmune diseases
    PETER KULAKOSKY; Fiscal Year: 2006
    ..Subsequently we found evidence indicating that HIAP is also involved in the development of juvenile rheumatoid arthritis, systemic lupus erythematosus, and Grave's disease...
  21. PAUCI JRA SYNOVIAL CYTOKINES
    David Glass; Fiscal Year: 2002
    ..that cytokines have a role in differentiating between the various clinical phenotypes that comprise juvenile rheumatoid arthritis (JRA), the commonest autoimmune rheumatic disease of childhood...
  22. ONSET AND PROGRESSION OF PUBERTY
    Jean Wilson; Fiscal Year: 1980
    ..3. Patients with juvenile rheumatoid arthritis - to determine the effect of J.R.A. on growth and development. 4...
  23. Leukocyte Microarrays in Juvenile Rheumatoid Arthritis
    James Jarvis; Fiscal Year: 2003
    b>Juvenile rheumatoid arthritis (JRA) is a family of illnesses characterized by chronic inflammation and hyperplasia of the synovial linings of joints...
  24. TRAINING IN CLINICAL IMMUNOLOGY
    Dennis Carson; Fiscal Year: 2000
    ..therapy; (6) control of immune responses by gene therapeutics; and (7) pathogenesis of juvenile rheumatoid arthritis. The research of the staff preceptors is dedicated to the elucidation of the fundamental pathogenic ..
  25. The Functional Muscle-Bone Unit in JRA
    Jon Burnham; Fiscal Year: 2009
    ..training in clinical epidemiology and a research focus on the musculoskeletal complications of juvenile rheumatoid arthritis (JRA)...
  26. Early Aggressive Treatment of Polyarticular JRA
    Carol Wallace; Fiscal Year: 2001
    ..functional ability and health related quality of life outcomes of children with poly articular juvenile rheumatoid arthritis (poly-JRA)...
  27. CLINICAL TRAILS IN PEDIATRIC RHEUMATOLOGY
    Daniel Lovell; Fiscal Year: 2004
    ..application is focused on the performance of two prospective, multicentered trials in children with juvenile rheumatoid arthritis (JRA)...
  28. Dynamics of Therapeutic Response Within the TREAT Trial
    James N Jarvis; Fiscal Year: 2010
    ....
  29. TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUS
    Hermine Brunner; Fiscal Year: 2007
    ..Abstract Not Provided ..
  30. Immune Tolerance after Severe Immunosuppression and Stem Cell Rescue for JIA
    Yukiko Kimura; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. Electronic Diary Assessment of Pain in Juvenile Arthritis
    Laura E Schanberg; Fiscal Year: 2010
    ..Finally, the study can serve as a catalyst for future research aimed at advancing medical and psychological knowledge of pain in other pediatric medical populations. ..
  32. GENES SPECIFIC TO B CELL GERMINAL CENTER REACTIONS
    Maria Pascual; Fiscal Year: 2002
    ..These studies may help reaching a better understanding of the connections between the processes of normal B cell differentiation and the development of germinal center malignancies. ..
  33. Headstrong Intervention for Recurrent Pediatric Headache
    Michael Rapoff; Fiscal Year: 2008
    ..The primary study outcome will be headache_ frequency, duration, and intensity as measured by daily headache diaries. Secondary endpoints will include ,headache-related disability outcomes and quality of life. _ ..... ..
  34. Genetic variation in T-cell regulatory molecules and JRA
    Sampath Prahalad; Fiscal Year: 2008
    b>Juvenile rheumatoid arthritis (JRA) is one of the most common chronic conditions of children affecting approximately 50,000 children in the U.S...
  35. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2008
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. [unreadable] [unreadable]..
  36. ECTOPIC GERMINAL CENTER REACTION IN SYSTEMIC LUPUS
    Maria Pascual; Fiscal Year: 2004
    ..3. To identify the + _ nature and function of the SLE-restricted CD19- CD20- cell populations that co-purify with B cells. 4. To determine the clinical relevance of the + _ accumulation f IgD+ CD38+ B cells and/or CD19- CD20- cells. ..
  37. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  38. Immune Complex Stimulation of TNFalpha
    Kathleen Sullivan; Fiscal Year: 2007
    ..In the third aim, we will define the role of chromatin in the regulation of responses to immune complexes. ..
  39. Tobacco Control Strategies for Medically At-Risk Youth
    Vida Tyc; Fiscal Year: 2005
    ..Working Group manuscripts that correspond to each objective will be published as a supplement to the journal, Pediatrics. ..
  40. GENETIC DISSECTION OF A BONE DYSPLASIA/CANCER SYNDROME
    John Martignetti; Fiscal Year: 2002
    ....
  41. Genomic Landscapes in Large Scale Integrated JRA Studies
    Susan Thompson; Fiscal Year: 2006
    b>Juvenile Rheumatoid Arthritis (JRA) is a heterogeneous group o f chronic pediatric arthropathies that a reinfluenced by a complex genetic trait and environmental factors...
  42. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
    ..These findings will have implications for therapeutic strategies to ameliorate acquired GH resistance in diseases complicated by liver inflammation, including chronic cholestatic liver diseases ..
  43. C-X-C Chemokines and Kaposi's Sarcoma
    DAVID MARKOVITZ; Fiscal Year: 2005
    ..This work thus has the potential to link KSHV, growth factors, and HIV/Tat in the pathogenesis of KS, and to suggest new avenues for the treatment of this complex neoplasm. ..
  44. Imaging Enzyme Structure and Dynamics: Specific Function and Functional Diversity
    Hua Deng; Fiscal Year: 2010
    ..The fruits of this work can lead to more thoroughly understanding disease and then to the discovery of new drugs and methods as well as laboratory diagnostic methods. ..
  45. Sensible Treatment of Obesity in Rural Youth- STORY
    David Janicke; Fiscal Year: 2006
    ..Findings will provide critical information for planning the R18 RCT. ..
  46. Extended Psychosocial Analysis of PHONE Study Data
    Janeen Manuel; Fiscal Year: 2003
    ..abstract_text> ..
  47. REGULATION OF HIV2 TRANSCRIPTION AND REPLICATION
    DAVID MARKOVITZ; Fiscal Year: 2002
    ..GLI-2/THP, a member of the GLI protooncogene family and DEK, previously associated with leukemia and juvenile rheumatoid arthritis, which we have shown to be a site-specific DNA-binding protein which mediates signal transduction ..
  48. CXC Chemokines and HIV Pathogenesis
    DAVID MARKOVITZ; Fiscal Year: 2009
    ..A mechanistic understanding of the interactions between HIV and these C-X-C chemokines could lead to the development of new approaches to the treatment of patients infected with HIV. ..
  49. Ontogeny of Drug Bioactivation and Idiosyncratic ADRs
    JAMES LEEDER; Fiscal Year: 2007
    ..abstract_text> ..
  50. VIBRATIONAL AND DYNAMICAL STUDIES OF ENZYMES
    Robert Callender; Fiscal Year: 2002
    ....
  51. Association of 7q22..1 gene VGF with obesity & leanness
    John Martignetti; Fiscal Year: 2008
    ..These physiologically linked, target-tissue genes may themselves play a functional role in obesity resistance or susceptibility, and thus become excellent candidates for future investigation. ..
  52. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  53. Reduction of ETS Exposure in Pediatric Cancer Patients
    Vida Tyc; Fiscal Year: 2006
    ..Our planned clinical trial may verify the effectiveness of an important clinical service for this vulnerable population that can be adapted for other pediatric oncology settings. ..