rheumatoid arthritis

Summary

Summary: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Top Publications

  1. ncbi Rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Lancet 373:659-72. 2009
  2. ncbi 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 62:2569-81. 2010
  3. pmc EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
    Josef S Smolen
    Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Ann Rheum Dis 69:964-75. 2010
  4. pmc Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
  5. pmc Treating rheumatoid arthritis to target: recommendations of an international task force
    Josef S Smolen
    Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Ann Rheum Dis 69:631-7. 2010
  6. ncbi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
  7. ncbi Rheumatoid arthritis
    David L Scott
    Department of Rheumatology, King s College London School of Medicine, London, UK
    Lancet 376:1094-108. 2010
  8. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
  9. ncbi Cytokines in the pathogenesis of rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 7:429-42. 2007
  10. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999

Detail Information

Publications283 found, 100 shown here

  1. ncbi Rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Lancet 373:659-72. 2009
    b>Rheumatoid arthritis is a systemic, inflammatory, autoimmune disorder. Enhanced understanding of molecular pathogenesis has enabled development of innovative biological agents that target specific parts of the immune system...
  2. ncbi 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 62:2569-81. 2010
    ..College of Rheumatology (ACR; formerly, the American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticized for their lack of sensitivity in early disease...
  3. pmc EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
    Josef S Smolen
    Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Ann Rheum Dis 69:964-75. 2010
    Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear and consensual international recommendations on RA treatment are not available...
  4. pmc Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent,..
  5. pmc Treating rheumatoid arthritis to target: recommendations of an international task force
    Josef S Smolen
    Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Ann Rheum Dis 69:631-7. 2010
    Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA).
  6. ncbi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
    ..College of Rheumatology (ACR; formerly the American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have been criticised for their lack of sensitivity in early disease...
  7. ncbi Rheumatoid arthritis
    David L Scott
    Department of Rheumatology, King s College London School of Medicine, London, UK
    Lancet 376:1094-108. 2010
    b>Rheumatoid arthritis is characterised by persistent synovitis, systemic inflammation, and autoantibodies (particularly to rheumatoid factor and citrullinated peptide)...
  8. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
    ..against tumor necrosis factor alpha (TNF-alpha) that is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 patients throughout the world have received infliximab...
  9. ncbi Cytokines in the pathogenesis of rheumatoid arthritis
    Iain B McInnes
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 7:429-42. 2007
    Cytokines regulate a broad range of inflammatory processes that are implicated in the pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance between pro- and anti-inflammatory cytokine activities ..
  10. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999
    ..Levels of IL-17 in synovial fluids were significantly higher in rheumatoid arthritis (RA) patients than osteoarthritis (OA) patients...
  11. pmc Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
    Beatrix Bartok
    Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, La Jolla, CA 92093, USA
    Immunol Rev 233:233-55. 2010
    b>Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages...
  12. pmc Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
    G Jones
    Menzies Research Institute, University of Tasmania, Hobart, TAS 7001, Australia
    Ann Rheum Dis 69:88-96. 2010
    The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis.
  13. ncbi Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    Solbritt Rantapaa-Dahlqvist
    Umea Universitet, Umea, Sweden
    Arthritis Rheum 48:2741-9. 2003
    ..the prevalence and predictive value of anti-cyclic citrullinated peptide (anti-CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) and to determine the relationship to rheumatoid factor (RF) of any isotype.
  14. pmc Golimumab, a human antibody to tumour necrosis factor {alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study
    E C Keystone
    University of Toronto and Mount Sinai Hospital, Ontario, Canada
    Ann Rheum Dis 68:789-96. 2009
    The phase III GO-FORWARD study examined the efficacy and safety of golimumab in patients with active rheumatoid arthritis (RA) despite methotrexate therapy.
  15. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0...
  16. ncbi Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 313:670-3. 2006
    ..This differential sialylation may provide a switch from innate anti-inflammatory activity in the steady state to generating adaptive pro-inflammatory effects upon antigenic challenge...
  17. pmc Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:2803-12. 2007
    ..T helper type 17 (Th17) cells predominantly express CC chemokine receptor (CCR) 6 in an animal model of rheumatoid arthritis (RA)...
  18. pmc Evidence that cytokines play a role in rheumatoid arthritis
    Fionula M Brennan
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    J Clin Invest 118:3537-45. 2008
    A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA)...
  19. ncbi LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    M C Genovese
    Stanford University, Palo Alto, California 94304, USA
    Arthritis Rheum 62:929-39. 2010
    ..pharmacodynamics, and efficacy of LY2439821, a humanized anti-interleukin-17 (anti-IL-17) monoclonal antibody, in a first in-human trial in rheumatoid arthritis (RA) patients taking oral disease-modifying antirheumatic drugs (DMARDs).
  20. ncbi Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I
    Charles G Helmick
    CDC, Atlanta, Georgia 30341 3717, USA
    Arthritis Rheum 58:15-25. 2008
    ..best available estimates of the US prevalence of and number of individuals affected by arthritis overall, rheumatoid arthritis, juvenile arthritis, the spondylarthritides, systemic lupus erythematosus, systemic sclerosis, and Sjögren'..
  21. pmc REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    Peter K Gregersen
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Nat Genet 41:820-3. 2009
    We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the REL locus, encoding c-Rel, on chromosome 2p13 (rs13031237, P = 6.01 x 10(-10))...
  22. pmc Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Arthritis Res Ther 10:R101. 2008
    ..In this study, the expression of selected microRNAs is examined in rheumatoid arthritis.
  23. ncbi Evolving concepts of rheumatoid arthritis
    Gary S Firestein
    Division of Rheumatology, Allergy and Immunology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0656, USA
    Nature 423:356-61. 2003
    b>Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several thousand years ago but might not have appeared in Europe until the 17th century...
  24. ncbi EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis
    M J L Peters
    Department of Rheumatology, VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 69:325-31. 2010
    To develop evidence-based EULAR recommendations for cardiovascular (CV) risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA).
  25. ncbi HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis
    Carlos Gonzalez-Juanatey
    Division of Cardiology, Hospital Xeral Calde, Dr Ochoa s n, 27004 Lugo, Spain
    Am J Med 114:647-52. 2003
    To examine endothelial function in rheumatoid arthritis patients and to assess whether clinical or genetic factors affect the development of endothelial dysfunction.
  26. ncbi State-of-the-art: rheumatoid arthritis
    Iain B McInnes
    Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, UK
    Ann Rheum Dis 69:1898-906. 2010
    The understanding of the pathogenesis and optimal therapeutics for rheumatoid arthritis (RA) has advanced remarkably over the last decade...
  27. ncbi High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine
    Noboru Taniguchi
    Faculty of Medicine, Kagoshima University, Japan
    Arthritis Rheum 48:971-81. 2003
    ..The purpose of this study was to demonstrate HMGB-1 expression in vivo and to identify the role of HMGB-1 in the pathogenesis of rheumatoid arthritis (RA).
  28. ncbi The variability of TCM pattern diagnosis and herbal prescription on rheumatoid arthritis patients
    Grant G Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA
    Altern Ther Health Med 10:58-63. 2004
    ..The consistency of diagnosis made among Traditional Chinese Medicine (TCM) practitioners and the relationship between TCM diagnosis and Chinese herbal prescription have not been adequately examined...
  29. ncbi Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    Heidi Kokkonen
    Umea University Hospital, Umea, Sweden
    Arthritis Rheum 62:383-91. 2010
    To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA).
  30. ncbi Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies
    J Antonio Aviña-Zubieta
    University of British Columbia and Arthritis Research Centre of Canada, British Columbia, Canada
    Arthritis Rheum 59:1690-7. 2008
    To determine the magnitude of risk of cardiovascular mortality in patients with rheumatoid arthritis (RA) compared with the general population through a meta-analysis of observational studies.
  31. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
    ..These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis...
  32. ncbi Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis
    Carlos Gonzalez-Juanatey
    Division of Cardiology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 38:366-71. 2009
    To establish whether carotid intima-media wall thickness (IMT) may be a good predictor for the development of cardiovascular (CV) events in patients with rheumatoid arthritis (RA).
  33. pmc Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Ann Rheum Dis 68:954-60. 2009
    ..To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR)...
  34. pmc Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate
    M Schiff
    Denver Arthritis Clinic, 200 Spruce Street 100, Denver, CO 80230, USA
    Ann Rheum Dis 67:1096-103. 2008
    ..The primary objective of this study was to evaluate the mean change from baseline in Disease Activity Score (based on erythrocyte sedimentation rates; DAS28 (ESR)) for the abatacept vs placebo groups at day 197...
  35. ncbi High-grade inflammation, circulating adiponectin concentrations and cardiovascular risk factors in severe rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:596-603. 2008
    ..are potential determinants of circulating adiponectin concentrations and whether low adiponectin levels cluster with metabolic syndrome features that are previously documented cardiovascular risk factors in rheumatoid arthritis (RA).
  36. ncbi The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis
    D Aletaha
    Department of Rheumatology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Clin Exp Rheumatol 23:S100-8. 2005
    Composite indices or pooled indices are useful tools for the evaluation of disease activity in patients with rheumatoid arthritis (RA)...
  37. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    b>Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory reaction in the synovium of joints and is associated with degeneration of cartilage and erosion of juxta-articular bone...
  38. ncbi HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Hospital Xeral Calde, Lugo, Spain
    Arthritis Rheum 57:125-32. 2007
    Cardiovascular (CV) disease is the most common cause of mortality in patients with rheumatoid arthritis (RA)...
  39. ncbi Interleukin-8 as a macrophage-derived mediator of angiogenesis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Science 258:1798-801. 1992
    ..These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair.
  40. pmc Macrophages in rheumatoid arthritis
    R W Kinne
    Experimental Rheumatology Unit, Friedrich Schiller University, Jena, Germany
    Arthritis Res 2:189-202. 2000
    ..of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA)...
  41. pmc Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    Tomoyuki Nakasa
    National Research Institute for Child Health and Development, Tokyo, Japan
    Arthritis Rheum 58:1284-92. 2008
    ..The objective of this study was to identify the expression pattern of microRNA-146 (miR-146) in synovial tissue from patients with rheumatoid arthritis (RA).
  42. pmc Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors
    R Westhovens
    UZ Gasthuisberg, Department of Rheumatology, B 3000 Leuven, Belgium
    Ann Rheum Dis 68:1870-7. 2009
    To assess the efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis (RA) and poor prognostic factors.
  43. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    K/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to rheumatoid arthritis. Disease in these animals is focused specifically on the joints but stems from autoreactivity to a ubiquitously expressed antigen,..
  44. ncbi The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
    To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment.
  45. ncbi Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-bli
    Paul Emery
    University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, corrected Leeds, UK
    Arthritis Rheum 60:2272-83. 2009
    To assess the safety and efficacy of golimumab in methotrexate (MTX)-naive patients with active rheumatoid arthritis (RA).
  46. ncbi Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    Hiba Mahdi
    Rheumatology Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Nat Genet 41:1319-24. 2009
    Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA- DRB1 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated peptides (CCP)...
  47. pmc Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research
    C Salliot
    Paris Descartes University, Medicine Faculty, Rheumatology B Department, Cochin Hospital, Paris, France
    Ann Rheum Dis 68:1100-4. 2009
    To perform a systematic literature review of the long-term safety of methotrexate (MTX) monotherapy in rheumatoid arthritis (RA).
  48. ncbi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
    b>Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease-specific autoimmunity to citrullinated proteins...
  49. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
    To assess the efficacy of low-dose prednisolone on joint damage and disease activity in patients with early rheumatoid arthritis (RA).
  50. pmc Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
    Matthew P Vincenti
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Arthritis Res 4:157-64. 2002
    ..collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis...
  51. ncbi Survival, comorbidities and joint damage 11 years after the COBRA combination therapy trial in early rheumatoid arthritis
    Lilian H D van Tuyl
    VU University Medical Center, Department of Rheumatology, ZH 3A 56, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Ann Rheum Dis 69:807-12. 2010
    ..for 'COmbinatie therapie Bij Rheumatoide Artritis') combination therapy is effective for the treatment of rheumatoid arthritis (RA), but long-term safety is unknown...
  52. pmc Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention
    Sougata Karmakar
    Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Medical Center, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA 01605, USA
    Rheum Dis Clin North Am 36:385-404. 2010
    In rheumatoid arthritis (RA), cells within the inflamed synovium and pannus elaborate a variety of cytokines, including tumor necrosis factor (TNF) alpha, interleukin (IL)-1, IL-6, and IL-17, that contribute to inflammation, and may ..
  53. ncbi Risk factors associated with different stages of atherosclerosis in Colombian patients with rheumatoid arthritis
    Adriana Rojas-Villarraga
    Cellular Biology and Immunogenetics Unit CBIGU, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
    Semin Arthritis Rheum 38:71-82. 2008
    b>Rheumatoid arthritis (RA) is associated with an increased prevalence of cardiovascular disease (CVD)...
  54. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    b>Rheumatoid arthritis (RA) is a chronic joint disease characterized by leukocyte invasion and synoviocyte activation followed by cartilage and bone destruction. Its etiology and pathogenesis are poorly understood...
  55. pmc Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study
    N Nishimoto
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Ann Rheum Dis 68:1580-4. 2009
    To evaluate the safety and efficacy of 5-year, long-term tocilizumab monotherapy for patients with rheumatoid arthritis.
  56. ncbi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  57. ncbi A simplified disease activity index for rheumatoid arthritis for use in clinical practice
    J S Smolen
    University of Vienna and Lainz Hospital, Austria
    Rheumatology (Oxford) 42:244-57. 2003
    The objective of this study was to verify the usefulness of a simple disease activity index (SDAI) for rheumatoid arthritis (RA).
  58. pmc Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis
    M Otero
    NEIRID NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Spain
    Ann Rheum Dis 65:1198-201. 2006
    b>Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment.
  59. ncbi A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 42:515-9. 2010
    b>Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology...
  60. ncbi Depression in rheumatoid arthritis: a systematic review of the literature with meta-analysis
    Chris Dickens
    Department of Psychiatry, Manchester University, Manchester, UK
    Psychosom Med 64:52-60. 2002
    This systematic review and meta-analysis examined the strength of association between rheumatoid arthritis and depression...
  61. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
    ..cells (Th17 cells), which mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA)...
  62. ncbi Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Rheumatol 32:811-9. 2005
    This study validated a brief measure of fatigue in rheumatoid arthritis (RA), the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale.
  63. ncbi PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Bioessays 25:1106-18. 2003
    ..we will discuss the effects of citrullination and its involvement in several human diseases, including rheumatoid arthritis and multiple sclerosis. So far, four isotypes of PAD have been described in mammals...
  64. ncbi Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
    B T Wipke
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 167:1601-8. 2001
    Neutrophils are prominent participants in the joint inflammation of human rheumatoid arthritis (RA) patients, but the extent of their role in the inductive phase of joint inflammation is unknown...
  65. pmc Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis
    Jingyi Li
    Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, District Shipingba, Chongqing 400038, PR China
    Arthritis Res Ther 12:R81. 2010
    ..The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA).
  66. pmc Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data
    J A P da Silva
    Reumatologia, Hospitais da Universidade, 3000 075 Coimbra, Portugal
    Ann Rheum Dis 65:285-93. 2006
    ..Safety data from recent randomised controlled clinical trials of low dose glucocorticoid treatment in RA suggest that adverse effects associated with this drug are modest, and often not statistically different from those of placebo...
  67. pmc Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score
    Daniel Aletaha
    Department of Rheumatology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R796-806. 2005
    Frequent assessments of rheumatoid arthritis (RA) disease activity allow timely adaptation of therapy, which is essential in preventing disease progression...
  68. ncbi Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis
    K Odink
    Department of Biotechnology, Ciba Geigy, Basel, Switzerland
    Nature 330:80-2. 1987
    ..Characterization of MRP-8 and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation...
  69. ncbi NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    J A Roman-Blas
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA19107 5541, USA
    Osteoarthritis Cartilage 14:839-48. 2006
    ..pathways to the pathogenesis of various rheumatic diseases, in particular, of osteoarthritis (OA) and rheumatoid arthritis (RA)...
  70. pmc Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
    Koichi Murata
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Arthritis Res Ther 12:R86. 2010
    ..In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA).
  71. pmc A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis
    G Freimanis
    Research Institute in Healthcare Sciences, University of Wolverhampton, UK
    Clin Exp Immunol 160:340-7. 2010
    ..with present-day exogenous retroviruses and have been linked previously with immunopathology within rheumatoid arthritis (RA). Mechanisms of pathogenesis for HERV-K in RA such as molecular mimicry were investigated...
  72. ncbi Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
    D Sugiyama
    Department of Clinical Pathology and Immunology, Kobe University Graduate Schoolof Medicine, Kobe 650 0017, Japan
    Ann Rheum Dis 69:70-81. 2010
    To assess whether smoking is a risk factor for developing rheumatoid arthritis (RA).
  73. ncbi Influence of anti-TNF-alpha infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:373-9. 2006
    Chronic systemic inflammation plays a pivotal role in the development of atherosclerosis in rheumatoid arthritis (RA). Soluble (s) adhesion molecules were found significantly increased in RA patients with active disease...
  74. pmc Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis
    Rachel A Harry
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Ann Rheum Dis 69:2042-50. 2010
    ..a promising experimental treatment for targeting autoreactive T cells in autoimmune diseases, including rheumatoid arthritis (RA). The authors' goal is to bring tolDC therapy for RA to the clinic...
  75. pmc Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    Jing Cui
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1849-61. 2010
    Anti-tumor necrosis factor alpha (anti-TNF) therapy is a mainstay of treatment in rheumatoid arthritis (RA)...
  76. ncbi Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
    The proinflammatory cytokine IL-17A is considered a crucial player in rheumatoid arthritis (RA) pathogenesis...
  77. pmc Electronic medical records for discovery research in rheumatoid arthritis
    Katherine P Liao
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:1120-7. 2010
    ..We assessed whether a classification algorithm incorporating narrative EMR data (typed physician notes) more accurately classifies subjects with rheumatoid arthritis (RA) compared with an algorithm using codified EMR data alone.
  78. ncbi The foot: still the most important reason for walking incapacity in rheumatoid arthritis: distribution of symptomatic joints in 1,000 RA patients
    Lollo Grondal
    Department of Molecular Medicine and Surgery, Orthopedic Rehabilitation, Karolinska Institute, Red Cross Hospital, Stockholm, Sweden
    Acta Orthop 79:257-61. 2008
    Our knowledge of frequency of foot involvement in rheumatoid arthritis (RA) is still often based on a study from Finland in 1956. Great changes in the treatment of RA may have led to a different situation...
  79. ncbi IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy
    Waldiceu A Verri
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Ann Rheum Dis 69:1697-703. 2010
    ..This study shows that IL-33 orchestrates neutrophil migration in arthritis...
  80. ncbi The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
    Joel M Kremer
    Albany Medical College, Albany, New York, USA
    Arthritis Rheum 60:1895-905. 2009
    ..of 3 different dosages of CP-690,550, a potent, orally active JAK inhibitor, in patients with active rheumatoid arthritis (RA) in whom methotrexate, etanercept, infliximab, or adalimumab caused an inadequate or toxic response.
  81. ncbi MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yuji Nakamachi
    Department of Clinical Laboratory, Kobe University Hospital, and Kobe University Graduate School of Medicine, Kobe, Japan
    Arthritis Rheum 60:1294-304. 2009
    To elucidate the role of microRNA (miRNA) in the pathogenesis of rheumatoid arthritis (RA), we analyzed synoviocytes from RA patients for their miRNA expression.
  82. ncbi Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 26:311-6. 2008
    Chronic systemic inflammation plays a pivotal role in the development of atherosclerosis in rheumatoid arthritis (RA)...
  83. ncbi Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients
    Herman van Wietmarschen
    Division of Analytical Biosciences, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    J Clin Rheumatol 15:330-7. 2009
    Complex chronic diseases such as rheumatoid arthritis have become a major challenge in medicine and for the pharmaceutical industry. New impulses for drug development are needed.
  84. ncbi Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study
    Linda A Merlino
    College of Public Health, University of Iowa, Iowa City
    Arthritis Rheum 50:72-7. 2004
    ..The influence of vitamin D on human autoimmune disease has not been well defined. The purpose of this study was to evaluate the association of dietary and supplemental vitamin D intake with rheumatoid arthritis (RA) incidence.
  85. ncbi The Work Limitations Questionnaire
    D Lerner
    The Health Institute, Division of Clinical Care Research, New England Medical Center, Boston, Massachusetts 02111, USA
    Med Care 39:72-85. 2001
    ..The objective of this work was to develop a psychometrically sound questionnaire for measuring the on-the-job impact of chronic health problems and/or treatment ("work limitations")...
  86. doi American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis
    Kenneth G Saag
    University of Alabama, Birmingham, AL, USA
    Arthritis Rheum 59:762-84. 2008
  87. ncbi Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression
    Alex J Zautra
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    J Consult Clin Psychol 76:408-21. 2008
    ..chronic stress, pain, and depression reduce pain and improve the quality of everyday life for adults with rheumatoid arthritis (RA)...
  88. ncbi Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity and radiographic outcome
    Lene S Knudsen
    Department of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    J Rheumatol 35:1277-87. 2008
    ..6 (pIL-6), plasma vascular endothelial growth factor (pVEGF), and serum (s) YKL-40 in patients with early rheumatoid arthritis (RA) and unclassified polyarthritis (PA), and investigate their relationship with radiographic outcome.
  89. ncbi Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    Josef S Smolen
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Lancet 371:987-97. 2008
    Interleukin 6 is involved in the pathogenesis of rheumatoid arthritis via its broad effects on immune and inflammatory responses...
  90. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    The prediction of response (or non-response) to anti-TNF treatment for rheumatoid arthritis (RA) is a pressing clinical problem...
  91. pmc The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    B Afzali
    Department of Nephrology and Transplantation, King s College London, Guy s and St Thomas Hospital, UK
    Clin Exp Immunol 148:32-46. 2007
    ..In this paper we review Th17/IL-17 and Treg biology and expand on this hypothesis...
  92. ncbi Role of inflammation in atherosclerosis associated with rheumatoid arthritis
    Peter Libby
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Med 121:S21-31. 2008
    b>Rheumatoid arthritis (RA) is associated with excess morbidity and mortality from myocardial infarction and allied disorders...
  93. ncbi Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients
    Joan H Pedersen-Lane
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    J Leukoc Biol 81:934-41. 2007
    Although the exact etiology of rheumatoid arthritis (RA) remains unknown, there is increasing evidence that reactive oxygen species and a pro-oxidant/antioxidant imbalance are an important part of the pathogenesis of joint tissue injury...
  94. ncbi Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Clin Rheumatol 26:1495-8. 2007
    Patients with rheumatoid arthritis (RA) have increased cardiovascular mortality. TNF-alpha is a critical mediator of inflammation and metabolic response in patients with RA...
  95. ncbi Health-related quality of life: validity, reliability, and responsiveness of SF-36, 15D, EQ-5D [corrected] RAQoL, and HAQ in patients with rheumatoid arthritis
    Louise Linde
    Department of Rheumatology, Copenhagen University Hospital, Hvidovre, Denmark
    J Rheumatol 35:1528-37. 2008
    To compare validity, reliability, and responsiveness of generic and disease specific health-related quality of life (HRQOL) instruments in rheumatoid arthritis (RA).
  96. ncbi The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS
    Beate Fuchs
    Institute of Medical Physics and Biophysics, Medical Department, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Clin Biochem 38:925-33. 2005
    ..g. lysophosphatidylcholines (LPC) are involved in the pathogenesis of inflammatory diseases, for instance, rheumatoid arthritis (RA). Unfortunately, the analysis of LPC in complex mixtures as present in body fluids is still challenging.
  97. ncbi Immunity to citrullinated proteins in rheumatoid arthritis
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet Karolinska University Hospital, SE 171 76, Stockholm, Sweden
    Annu Rev Immunol 26:651-75. 2008
    ..modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA)...
  98. ncbi Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy
    M C Genovese
    Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road 203, Palo Alto, CA 94304, USA
    Ann Rheum Dis 67:547-54. 2008
    To evaluate the safety and efficacy of abatacept during 2 years of the ATTAIN (Abatacept Trial in Treatment of Anti-TNF INadequate responders) trial in patients with rheumatoid arthritis.
  99. ncbi Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA
    J L Nam
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, 2nd Floor, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 69:976-86. 2010
    To review the evidence for the efficacy and safety of biological agents in patients with rheumatoid arthritis (RA) to provide data to develop treatment recommendations by the European League Against Rheumatism (EULAR) Task Force.
  100. ncbi An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
    Michael E Weinblatt
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 363:1303-12. 2010
    ..The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy.
  101. ncbi Short-term adalimumab therapy improves endo-thelial function in patients with rheumatoid arthritis refractory to infliximab
    C Gonzalez-Juanatey
    Cardiology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 24:309-12. 2006
    Endothelial dysfunction has been found in patients with rheumatoid arthritis (RA)...

Research Grants78

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..substantially increases the risk of systemic illness such as cardiovascular and renal disease, rheumatoid arthritis, and pregnancy complications...
  5. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..in vivo using an anti-CD20 antibody that mimics the agent Rituximab, now used in humans to treat refractory Rheumatoid Arthritis and certain B cell lymphomas...
  6. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..Our preliminary data indicate that compared to rheumatoid arthritis (RA) and osteoarthritis (OA), the synovium of PsA is rich in NGF;major source of NGF is FLS;TrkA is ..
  7. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..elevated levels of OPN-R and its CPB-cleaved product, OPN-Leu (OPN-L), in synovial fluid samples from rheumatoid arthritis patients and these cleaved OPN forms affect neutrophils and fibroblast-like synoviocytes...
  8. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..It is a serious complication of many chronic inflammatory diseases including rheumatoid arthritis, ankylosing spondylitis, regional enteritis (Crohn's disease), and inherited recurrent febrile ..
  9. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Malfunctioning B cells are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. To function effectively, B cells need to migrate in the lymphoid tissues for surveillance, and upon ..
  10. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..allele of CTLA-4 that reduces N-glycan number by ~50%, increasing the risk of Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) by ~2 fold...
  11. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    PROJECT SUMMARY\ABSTRACT Predisposition to develop Rheumatoid arthritis (RA) is associated with the presence of certain HLA alleles while others offer resistance...
  12. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..Behavioral and Biomedical Research Approaches in Arthritis and Musculoskeletal Diseases" Patients with rheumatoid arthritis (RA), other chronic arthritides and other autoimmune diseases inflammatory or not, have partial chronic ..
  13. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..Multiple sclerosis, rheumatoid arthritis, pediatric arthritis, insulin-dependent diabetes, idiopathic thrombocytopenia and pediatric lupus are other ..
  14. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..been shown to be a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  15. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..disease, Parkinson's disease, multiple sclerosis, inflammatory bowel disease, kidney disease, rheumatoid arthritis and chronic obstructive pulmonary disease, where aberrant MPO activity has been implicated...
  16. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..mechanism of enhanced susceptibility to diverse syndromes including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Type I diabetes (T1D)...
  17. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..decreased serum levels of 25(OH)VD3 have been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and multiple sclerosis (MS)...
  18. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..Systemic AA amyloidosis is associated mostly with chronic inflammatory disorders and includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's ..
  19. OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITIS
    Cornelia M Weyand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a quintessential autoimmune syndrome with tissue-destructive chronic inflammatory lesions attacking the synovium and a wide spectrum of extra-articular organs...
  20. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Anti-IL-12p40 antibodies (Ustekinumab) which suppress Th17 cytokine elaboration have recently been ..
  21. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..This murine model (PG-induced arthritis;PGIA) shares similarities with rheumatoid arthritis (RA) as indicated by clinical assessments, laboratory tests, x-ray and histopathology of diarthrodial ..
  22. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Description: In rheumatoid arthritis (RA), an inflammatory stimulus from secreted cytokines increases osteoclast activity, erodes bone surfaces, and progressively destroys joints...
  23. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..preclinical efficacy of non-hormonal steroids in a mouse model of limb girdle muscular dystrophy 22B, rheumatoid arthritis and asthma...
  24. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..by physicians over several decades to treat inflammatory disorders including chronic fatigue syndrome, rheumatoid arthritis, asthma, neurological diseases and eczema, with little understanding as to why B12 supplementation is ..
  25. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..by demonstrating that autoreactive T cells from patients with multiple sclerosis, type-1 diabetes and rheumatoid arthritis are predominantly Kv1.3high TEM cells and that Kv1...
  26. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Current therapeutic approaches to rheumatoid arthritis ("RA") (corticosteroids, methotrexate, neutralization of TNF-?) rely upon broad-spectrum immunosuppression, an approach that is not uniformly ..
  27. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer and rheumatoid arthritis (RA) share remarkably similar pathogenic pathways...
  28. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..Matloubian, Abbas, and Anderson. Abstract of Research Project: Rheumatoid arthritis (RA), one of the most common human autoimmune diseases, primarily affects the synovial membranes of joints...
  29. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..Building upon her prior work which evaluated quality measures and patient safety in rheumatoid arthritis and systemic lupus erythematosus (JAMA 2011;305(5):480;Semin Arthritis Rheum 2011;40(6):559), the proposed ..
  30. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Veena Taneja; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Predisposition to develop Rheumatoid arthritis (RA) is associated with the presence of certain HLA class II genes while others offer resistance from arthritis...
  31. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..In this regard, the chronic inflammation occurring in inflammatory bowel disease and rheumatoid arthritis have many similarities to the chronic immunoinflammatory response in the oral cavity that destroys the soft ..
  32. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..e., rheumatoid arthritis, systemic lupus erythematosus, and Sjvgren's syndrome)...
  33. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..B-cells contribute substantially to the immunopathogenesis of chronic systemic autoimmune diseases such as rheumatoid arthritis (RA), Sjogren's syndrome and systemic lupus erythematosus (SLE)...
  34. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..and the ability to distinguish the roles of autoantibodies and inflammatory responses in the development of rheumatoid arthritis. BXD2 mice develop spontaneous erosive arthritis and generalized autoimmune disease...
  35. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Rheumatoid arthritis is a disabling disease that leads to joint destruction...
  36. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..He will draw on outstanding resources, including the VA Rheumatoid Arthritis national registry as well as the CTSA-supported Center for Clinical and Translational Research, and the ..
  37. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..These diseases would include not only bacterial sepsis, but diseases such as rheumatoid arthritis, diabetes, stroke, CNS cancers, and even obesity and Alzheimer's disease in which proinflammatory and ..
  38. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is the most common inflammatory joint disease of autoimmune etiology...
  39. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..As well as other chronic inflammatory diseases (rheumatoid arthritis, lupus, etc...
  40. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..topic (the role of bone marrow as secondary lymphoid tissue) thereby bringing another autoimmune disease (Rheumatoid Arthritis) under the umbrella of the ACE. Finally, Dr...
  41. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..with suggestions that inappropriate expression may contribute to pathologic inflammatory states such as rheumatoid arthritis or COPD...
  42. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..autoreactive T cells in patients with multiple sclerosis (MS), type-1 diabetes mellitus (T1DM) and rheumatoid arthritis (RA) are TEM cells with elevated expression of Kv1.3 channels...
  43. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..OA), affecting over 27 million Americans, other forms of the disease are also prevalent, including rheumatoid arthritis, juvenile arthritis and gout...
  44. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..For example, patients with rheumatoid arthritis or systemic lupus erythematosus (SLE) are at increased risk for developing coronary artery disease...
  45. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..bone metabolism in healthy women, and to be beneficial for people with fibromyalgia, osteoarthritis and rheumatoid arthritis;however, no randomized trial has examined the impact of exercise on arthralgia or bone mass in breast ..
  46. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Humanized transgenic mice reproduce the disease evolution in severe RA Rheumatoid arthritis (RA) is a common autoimmune disease in humans genetically associated with specific HLA class II alleles...
  47. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..for adenosine have been targeted for such diverse conditions as Parkinson's Disease and, indirectly, Rheumatoid Arthritis. Few studies have addressed the role of adenosine and its receptors in bone metabolism despite clear ..
  48. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..of auto-antibodies that serve as biomarkers for thyroiditis, type I diabetes, pernicious anemia, and rheumatoid arthritis in CD cases...
  49. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    ..trophozoites, we found one drug, auranofin, an oral gold-containing compound approved in 1985 to treat rheumatoid arthritis, had an IC50 of 0.5 [unreadable]M, 10-fold lower than metronidazole (5.2 [unreadable]M)...
  50. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..AND ESTROGEN RECEPTORS REGULATE DENDRITIC CELLS IN INFLAMMATION Abstract Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are strongly female biased, yet the cellular and molecular basis for this is not ..
  51. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..It is estimated that approximately 5% of the US population is affected by an autoimmune disorder such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or multiple sclerosis (MS)...
  52. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..chronic diseases like atopic dermatitis, inflammatory bowel disease, irritable bowel syndrome, asthma, and rheumatoid arthritis. Certain cytokines, notably Interleukin-31 (IL-31) and its related cytokine Oncostatin M (OSM), directly ..
  53. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..Aim 2: Women with endometriosis are at greater risk of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), and Grave's disease...
  54. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..While rheumatoid arthritis (RA) and osteoarthritis (OA) are largely age and use related, osteoarthritis can result from injury at any ..
  55. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    ..endothelial Fc?RIIB will also be valuable in understanding why immune complex-mediated diseases such as rheumatoid arthritis and lupus are complicated by both cardiovascular disease and insulin resistance...
  56. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..of bone diseases such as osteoporosis, Paget's disease of bone, metastatic osteolytic lesions, and rheumatoid arthritis. However, the molecular mechanisms underlying osteoclastogenesis are not well understood...
  57. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    ..T cells also accumulate at sites of inflammation in autoimmune syndromes such as in the synovial tissue in rheumatoid arthritis, the bowel in celiac disease, or the lungs in sarcoidosis...
  58. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes Schiffer; Fiscal Year: 2010
    ..effects of inhibiting this enzyme have been used therapeutically to treat diseases such as rheumatoid arthritis. The third specific aim centers on the enzyme lipoxygenase...
  59. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..and other health issues including heart disease, stroke, diabetes, pre-term low term birth weight, rheumatoid arthritis, and chronic kidney disease...
  60. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    PROJECT SUMMARY Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder in which activated synovial fibroblasts produce chemokines that facilitate the invasion of the articular cartilage and underlying bone by the release of ..
  61. MIF in progression and treatment of ALD
    Laura E Nagy; Fiscal Year: 2013
    ..and are associated with the incidence or severity of a number of inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease and asthma...
  62. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a chronic inflammatory disease of the articular joints...
  63. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..Title: Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis Project Summary/Abstract Rheumatoid arthritis (RA) is the most common inflammatory joint disease of ..
  64. ACTIVATION OF COLLAGENASE IN RHEUMATOID ARTHRITIS
    L Windsor; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the applicant's abstract) - Rheumatoid arthritis is characterized by chronic inflammation and joint degeneration...
  65. AREA: Synthesis and Evaluation of New Cathepsin B, D, and K Inhibitors
    Rose McConnell; Fiscal Year: 2009
    ..Cathepsin K has been associated with accelerated bone degradation in patients with osteoporosis, rheumatoid arthritis, lung cancer, prostate cancer, and breast cancer...
  66. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..Unfortunately, diseases affecting the skeleton such as osteoporosis, rheumatoid arthritis, and cancer, tilt the delicate balance of bone destruction and bone formation toward the prior, leading to ..
  67. The Treatment of Methotrexate Resistant Rheumatoid Arthritis With Aminopterin
    Stuart Kahn; Fiscal Year: 2009
    ..is to develop aminopterin (AMT), an antifolate medication, as an improved treatment for patients with rheumatoid arthritis (RA) and other inflammatory diseases...
  68. Bc12 regulates osteoclast survival
    Junro Yamashita; Fiscal Year: 2010
    Bone degenerative diseases such as osteoporosis, periodontitis, and rheumatoid arthritis are major health care concerns for the elderly population that is rapidly increasing in the US...
  69. ANTI-ANGIOGENIC GENE THERAPY FOR RHEUMATOID ARTHRITIS
    Noriyuki Kasahara; Fiscal Year: 2001
    ..potential of the angiogenesis inhibitors thrombospondin-1, angiostatin, and endostatin, for gene therapy of rheumatoid arthritis. Using lentiviral and helper-dependent adenoviral vectors as gene delivery systems for these angiogenesis ..
  70. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    Despite remarkable recent advances in therapeutics, rheumatoid arthritis still represents an unmet medical need...
  71. Randomized observation study of biologic therapy for rheumatoid arthritis
    LARRY W contact MORELAND; Fiscal Year: 2010
    ..needed to determine the relative merits of existing versus new and expensive biologic drug therapies for rheumatoid arthritis (RA)...
  72. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is one of the most common forms of arthritis, a potentially crippling autoimmune disease that affects more than two million Americans...
  73. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    MICHELLE URBAN; Fiscal Year: 1999
    ..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
  74. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    John McGuire; Fiscal Year: 2001
    ..The efficacy of TES has not yet been examined in the child with juvenile rheumatoid arthritis (JRA)...
  75. ANDROGEN AS ADJUNCT THERAPY IN RHEUMATOID ARTHRITIS
    John Davis; Fiscal Year: 2002
    b>Rheumatoid arthritis (RA) is a chronic, debilitating multisystem disease affecting nearly two million persons in the United States alone...
  76. TYPE V COLLAGENASE IN RHEUMATOID ARTHRITIS
    Tayebeh Pourmotabbed; Fiscal Year: 2001
    ..Nowhere is this degradative ability more apparent than in rheumatoid arthritis. In this disease, excessive production of metalloproteinases mediates the degradation of articular ..
  77. Development of immunoassay to measure a novel TNF-like protein
    Sunghee Kim; Fiscal Year: 2007
    ..inflammatory diseases can be readily evidenced by the success of TNF inhibitors to treat diseases including rheumatoid arthritis and inflammatory bowel disease. We have reported the discovery of TL1A, a TNF-like cytokine...
  78. Genetic Polymorphisms in Rheumatoid Arthritis
    Eric Matteson; Fiscal Year: 2004
    About one-third of patients who have rheumatoid arthritis (RA) develop symptoms of inflammation outside the synovium, so-called extra-articular manifestations (ExRA), such as pericarditis, pleuritis, interstitial lung disease, Felty's ..