knee osteoarthritis

Summary

Summary: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Top Publications

  1. ncbi OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
    W Zhang
    University of Edinburgh, Osteoarticular Research Group, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Osteoarthritis Cartilage 16:137-62. 2008
  2. ncbi OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009
    W Zhang
    Nottingham City Hospital, University of Nottingham, Nottingham, UK
    Osteoarthritis Cartilage 18:476-99. 2010
  3. pmc EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
    K M Jordan
    Southampton General Hospital, Southampton S016 6YD, UK
    Ann Rheum Dis 62:1145-55. 2003
  4. pmc Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
    G Peat
    Primary Care Sciences Research Centre, Keele University, UK
    Ann Rheum Dis 60:91-7. 2001
  5. pmc The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis
    Ewa M Roos
    Department of Orthopaedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 1:64. 2003
  6. ncbi Sensitization in patients with painful knee osteoarthritis
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 149:573-81. 2010
  7. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
  8. ncbi Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94
    Charles F Dillon
    Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, DHANES, 3311 Toledo Road, Hyattsville, MD 20782, USA
    J Rheumatol 33:2271-9. 2006
  9. ncbi Increased joint loads during walking--a consequence of pain relief in knee osteoarthritis
    Marius Henriksen
    The Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
    Knee 13:445-50. 2006
  10. ncbi Predicting the outcome of total knee arthroplasty
    Elizabeth A Lingard
    Brigham and Women s Hospital, 75 FrancisStreet, Boston, MA 02115, USA
    J Bone Joint Surg Am 86:2179-86. 2004

Detail Information

Publications375 found, 100 shown here

  1. ncbi OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
    W Zhang
    University of Edinburgh, Osteoarticular Research Group, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Osteoarthritis Cartilage 16:137-62. 2008
    ..up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied health care professionals in general ..
  2. ncbi OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009
    W Zhang
    Nottingham City Hospital, University of Nottingham, Nottingham, UK
    Osteoarthritis Cartilage 18:476-99. 2010
    To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009.
  3. pmc EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
    K M Jordan
    Southampton General Hospital, Southampton S016 6YD, UK
    Ann Rheum Dis 62:1145-55. 2003
    To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach.
  4. pmc Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
    G Peat
    Primary Care Sciences Research Centre, Keele University, UK
    Ann Rheum Dis 60:91-7. 2001
    ..Osteoarthritis is the single most common cause of disability in older adults, and most patients with the condition will be managed in the community and primary care...
  5. pmc The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis
    Ewa M Roos
    Department of Orthopaedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 1:64. 2003
    ..The measure is relatively new and further use of the instrument will add knowledge and suggest areas that need to be further explored and improved...
  6. ncbi Sensitization in patients with painful knee osteoarthritis
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 149:573-81. 2010
    ..This study highlights the importance of central sensitization as an important manifestation in knee OA...
  7. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
    To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury.
  8. ncbi Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94
    Charles F Dillon
    Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, DHANES, 3311 Toledo Road, Hyattsville, MD 20782, USA
    J Rheumatol 33:2271-9. 2006
    To estimate the US national prevalence of tibiofemoral radiographic knee osteoarthritis (RKOA) with and without symptoms, and its influence on functional tasks.
  9. ncbi Increased joint loads during walking--a consequence of pain relief in knee osteoarthritis
    Marius Henriksen
    The Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
    Knee 13:445-50. 2006
    Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear...
  10. ncbi Predicting the outcome of total knee arthroplasty
    Elizabeth A Lingard
    Brigham and Women s Hospital, 75 FrancisStreet, Boston, MA 02115, USA
    J Bone Joint Surg Am 86:2179-86. 2004
    ..This paper examines the preoperative predictors of pain and functional outcome at one and two years following total knee arthroplasty...
  11. pmc The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature
    John Bedson
    Arthritis Research Campaign National Primary Care Centre, Keele University, Staffordshire, ST5 5BG, United Kingdom
    BMC Musculoskelet Disord 9:116. 2008
    Studies have suggested that the symptoms of knee osteoarthritis (OA) are rather weakly associated with radiographic findings and vice versa...
  12. ncbi A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
    Velandai K Srikanth
    The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
    Osteoarthritis Cartilage 13:769-81. 2005
    ..To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity...
  13. pmc The Dutch version of the Knee Injury and Osteoarthritis Outcome Score: a validation study
    Ingrid B de Groot
    Department of Orthopaedics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Health Qual Life Outcomes 6:16. 2008
    ..The purpose of the present study was to evaluate the clinimetric properties of the Dutch version of the KOOS questionnaire in knee patients with various stages of osteoarthritis (OA)...
  14. ncbi The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis
    Thomas P Andriacchi
    Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, Stanford, CA 94305, USA
    Curr Opin Rheumatol 18:514-8. 2006
    ..This review examines recent in-vivo studies of ambulation and discusses the fundamental role of mechanics of ambulation in the initiation and progression of osteoarthritis at the knee...
  15. ncbi Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study
    L S Lohmander
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Ann Rheum Dis 68:490-6. 2009
    ..To determine in a prospective population-based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis...
  16. ncbi OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited
    T Pham
    Rene Descartes University, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Osteoarthritis Cartilage 12:389-99. 2004
    ..For each domain, a response was defined by both a relative and an absolute change, with different cut-offs with regard to the drug, the route of administration and the OA localization...
  17. pmc Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement
    F Tubach
    Institut National de la Sante et de la Recherche Medicale, Département d Epidémiologie, Biostatistique et Recherche Clinique, 75018 Paris, France
    Ann Rheum Dis 64:29-33. 2005
    ..In clinical trials, at the group level, results are usually reported as mean and standard deviation of the change in score, which is not meaningful for most readers...
  18. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee...
  19. ncbi Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
    Brian M Berman
    University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
    Ann Intern Med 141:901-10. 2004
    ..Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal...
  20. ncbi Atlas of individual radiographic features in osteoarthritis, revised
    R D Altman
    The David Geffen School of Medicine, The University of California at Los Angeles, Los Angeles, CA 91390, USA
    Osteoarthritis Cartilage 15:A1-56. 2007
    ..Develop a radiographic atlas of osteoarthritis (OA) to be used as a template and guide for grading radiographs of osteoarthritic lesions of the hand, hip and knee...
  21. pmc Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
    T Miyazaki
    Department of Orthopaedic Surgery, Fukui Medical University, Japan
    Ann Rheum Dis 61:617-22. 2002
    To test the hypothesis that dynamic load at baseline can predict radiographic disease progression in patients with medial compartment knee osteoarthritis (OA).
  22. ncbi Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs
    Kristen Johnson
    Veterans Affairs Medical Center, and University of California, San Diego, 92161, USA
    Arthritis Rheum 50:1216-25. 2004
    ..Nitric oxide (NO) potently suppresses mitochondrial oxidative phosphorylation. Because enhanced cartilage NO generation occurs in osteoarthritis (OA), we systematically tested for mitochondrial dysfunction in the pathogenesis of OA...
  23. ncbi Effect of a home program of hip abductor exercises on knee joint loading, strength, function, and pain in people with knee osteoarthritis: a clinical trial
    Elizabeth A Sled
    School of Rehabilitation Therapy, Queen s University, L D Acton Building, 31 George St, Kingston, Ontario, Canada K7L 3N6
    Phys Ther 90:895-904. 2010
    Hip abductor muscle weakness may result in impaired frontal-plane pelvic control during gait, leading to greater medial compartment loading in people with knee osteoarthritis (OA).
  24. ncbi Randomized controlled trial of diclofenac sodium gel in knee osteoarthritis
    H Richard Barthel
    Semin Arthritis Rheum 39:203-12. 2009
    ..This study assessed the efficacy and safety of topical diclofenac sodium 1% gel (DSG) in mild to moderate symptomatic knee osteoarthritis.
  25. ncbi Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project
    Joanne M Jordan
    Thurston Arthritis Research Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
    J Rheumatol 34:172-80. 2007
    ..To report contemporary estimates of the prevalence of knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years...
  26. ncbi An update on the pathogenesis and epidemiology of osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA
    Radiol Clin North Am 42:1-9, v. 2004
    ..The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion...
  27. pmc Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review
    E Roddy
    Academic Rheumatology, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 64:544-8. 2005
    To compare the efficacy of aerobic walking and home based quadriceps strengthening exercises in patients with knee osteoarthritis.
  28. ncbi Determining the need for hip and knee arthroplasty: the role of clinical severity and patients' preferences
    G A Hawker
    Faculty of Medicine, University of Toronto, Ontario, Canada
    Med Care 39:206-16. 2001
    ..Area variation in the use of surgical interventions such as arthroplasty is viewed as concerning and inappropriate...
  29. ncbi Acupuncture and knee osteoarthritis: a three-armed randomized trial
    Hanns Peter Scharf
    University of Heidelberg, Heidelberg, Germany
    Ann Intern Med 145:12-20. 2006
    ..Despite the popularity of acupuncture, evidence of its efficacy for reducing pain remains equivocal...
  30. ncbi Treatment of knee osteoarthritis with pulsed electromagnetic fields: a randomized, double-blind, placebo-controlled study
    G Thamsborg
    Department of Geriatri and Rheumatology, Glostrup Hospital, 2600 Glostrup, Denmark
    Osteoarthritis Cartilage 13:575-81. 2005
    ..The investigation aimed at determining the effectiveness of pulsed electromagnetic fields (PEMF) in the treatment of osteoarthritis (OA) of the knee by conducting a randomized, double-blind, placebo-controlled clinical trial...
  31. pmc Knee injury and Osteoarthritis Outcome Score (KOOS) - validation and comparison to the WOMAC in total knee replacement
    Ewa M Roos
    Department of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 1:17. 2003
    ..KOOS was developed for younger and/or more active patients with knee injury and knee osteoarthritis and has in previous studies on these groups been the more responsive instrument compared to the WOMAC...
  32. pmc Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis
    Robin Christensen
    The Parker Institute, H S Frederiksberg Hospital, DK 2000 Frederiksberg, and Copenhagen University Library, Denmark
    Ann Rheum Dis 66:433-9. 2007
    ..of randomised controlled trials (RCTs) changes in pain and function when overweight patients with knee osteoarthritis (OA) achieve a weight loss...
  33. ncbi Tai chi improves physical function in older Chinese women with knee osteoarthritis
    Guo Xin Ni
    Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou, China
    J Clin Rheumatol 16:64-7. 2010
    ..Tai chi (TC) is proposed as a potential option for the management of osteoarthritis (OA), however, its beneficial effect on patients with knee OA has not been convincing...
  34. ncbi Gait characteristics of patients with knee osteoarthritis
    K R Kaufman
    Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, MN, USA
    J Biomech 34:907-15. 2001
    The knee kinematics and kinetics of 139 patients (47 males and 92 females) with Grade II knee osteoarthritis (OA) were measured during level walking, stair ascent and stair descent...
  35. ncbi Knee osteoarthritis clinical practice guidelines -- how are we doing?
    Melanie N DeHaan
    Division of Physiatry, Department of Medicine, University of Toronto, Canada
    J Rheumatol 34:2099-105. 2007
    To determine the degree to which documented knee osteoarthritis (OA) care in a teaching rheumatology clinic corresponds to evidence-based treatment guidelines.
  36. ncbi Primary care treatment of knee pain--a survey in older adults
    M Porcheret
    Primary Care Musculoskeletal Research Centre, Primary Care Sciences, Keele University, Keele, Staffs ST5 5BG, UK
    Rheumatology (Oxford) 46:1694-700. 2007
    ..To describe the treatment of knee pain in older adults in primary care and to compare reported practice with published evidence...
  37. ncbi The knee adduction moment during gait in subjects with knee osteoarthritis is more closely correlated with static alignment than radiographic disease severity, toe out angle and pain
    D E Hurwitz
    Department of Orthopedic Surgery, Rush Presbyterian St Luke s Medical Center, Rush Medical College of Rush University, Chicago, IL 60612, USA
    J Orthop Res 20:101-7. 2002
    This study tested whether the peak external knee adduction moments during walking in subjects with knee osteoarthritis (OA) were correlated with the mechanical axis of the leg, radiographic measures of OA severity, toe out angle or ..
  38. ncbi Balance impairments in individuals with symptomatic knee osteoarthritis: a comparison with matched controls using clinical tests
    R S Hinman
    Centre for Sports Medicine Research and Education, School of Physiotherapy, University of Melbourne, Victoria, Australia
    Rheumatology (Oxford) 41:1388-94. 2002
    To compare balance in individuals with symptomatic knee osteoarthritis (OA) and in age-, gender- and body-mass-matched controls using simple clinical measures.
  39. ncbi Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease
    C R Scanzello
    Rush University Medical Center, Section of Rheumatology, 1725 W Harrison Street, Suite 1017, Chicago, IL 60612, United States
    Osteoarthritis Cartilage 17:1040-8. 2009
    ....
  40. ncbi A comparison of outcomes in osteoarthritis patients undergoing total hip and knee replacement surgery
    C J Bachmeier
    Departments of Medicine and Orthopaedics, St Vincent's Hospital, University of New South Wales, Australia
    Osteoarthritis Cartilage 9:137-46. 2001
    ..For a follow-up longer than 6 months MOS SF-36 provides additional information. The improvement in outcomes following hip joint surgery were significantly greater than those following knee surgery...
  41. pmc Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials
    Jan Magnus Bjordal
    Department of Public Health and Primary Health Care, University of Bergen, 5018 Bergen, Norway
    BMJ 329:1317. 2004
    ..To estimate the analgesic efficacy of non-steroidal anti-inflammatory drugs (NSAIDs), including selective cyclo-oxygenase-2 inhibitors (coxibs), in patients with osteoarthritis of the knee...
  42. ncbi Cross-cultural adaptation and validation of the French version of the Knee injury and Osteoarthritis Outcome Score (KOOS) in knee osteoarthritis patients
    P Ornetti
    Department of Rheumatology, Dijon University Hospital, F 21079, France
    Osteoarthritis Cartilage 16:423-8. 2008
    ..To adapt the Knee injury and Osteoarthritis Outcome Score (KOOS) into French and to evaluate the psychometric properties of this new version...
  43. ncbi Physical functioning over three years in knee osteoarthritis: role of psychosocial, local mechanical, and neuromuscular factors
    Leena Sharma
    Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 48:3359-70. 2003
    To identify factors that predict a poor physical function outcome over 3 years in individuals with knee osteoarthritis (OA), in an effort to aid in the development of strategies to prevent such functional limitations and consequential ..
  44. ncbi Lifetime risk of symptomatic knee osteoarthritis
    Louise Murphy
    Business Computer Applications, Atlanta, Georgia, USA
    Arthritis Rheum 59:1207-13. 2008
    To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history of knee injury, and body mass index (BMI).
  45. ncbi Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib
    M Bianchi
    Department of Pharmacology, University of Milan, Milan, and Unit of Rheumatology, A O Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Int J Clin Pract 61:1270-7. 2007
    This study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA)...
  46. ncbi Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
    J P Raynauld
    University of Montreal Hospital Centre, Notre Dame Hospital, Quebec, Canada
    Ann Rheum Dis 68:938-47. 2009
    In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison with naproxen in patients with knee osteoarthritis (OA), using MRI and x-ray examination.
  47. ncbi Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
    X Ayral
    Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
    Osteoarthritis Cartilage 13:361-7. 2005
    To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage.
  48. pmc Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Box 406, Tufts University School of Medicine, Boston, MA 02111, USA
    Arthritis Rheum 61:1545-53. 2009
    To evaluate the effectiveness of Tai Chi in the treatment of knee osteoarthritis (OA) symptoms.
  49. pmc Effect of pain reduction on postural sway, proprioception, and quadriceps strength in subjects with knee osteoarthritis
    B S Hassan
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
    Ann Rheum Dis 61:422-8. 2002
    To investigate whether alleviation of knee pain influences quadriceps function, proprioceptive acuity, and postural stability in patients with knee osteoarthritis (OA).
  50. ncbi Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis st
    Clifton O Bingham
    Division of Rheumatology, Johns Hopkins University, 5200 Eastern Avenue, Mason F Lord Building, Center Tower, Room 404, Baltimore, MD 21224, USA
    Arthritis Rheum 54:3494-507. 2006
    ....
  51. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
    ..the peak external knee adduction moment during gait is increased in a group of ambulatory subjects with knee osteoarthritis (OA) of varying radiographic severity who are being managed with medical therapy...
  52. ncbi Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis
    Lee S Simon
    SDG LLC Consulting, 124 Mt Auburn Street, Cambridge, MA, USA
    Pain 143:238-45. 2009
    ..oral diclofenac (ODiclo) and the combination of TDiclo+ODiclo for relieving the signs and symptoms of knee osteoarthritis. Subjects applied study solution, 40 drops four times daily, and took one study tablet daily for 12 weeks...
  53. pmc Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study
    M Reijman
    Department of Orthopedics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Ann Rheum Dis 66:158-62. 2007
    ..To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis...
  54. ncbi Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis
    C G Peterfy
    Synarc, Inc, San Francisco, CA 94105, USA
    Osteoarthritis Cartilage 12:177-90. 2004
    ..To determine the inter-observer agreement of this scoring method. To examine associations among the features included in the scoring method...
  55. ncbi The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
    Tadashi Hayami
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Arthritis Rheum 50:1193-206. 2004
    ....
  56. ncbi Knee osteoarthritis after anterior cruciate ligament injury: a systematic review
    Britt Elin Øiestad
    Norwegian Research Center for Active Rehabilitation NAR, Ullevaal University Hospital, Oslo, Norway
    Am J Sports Med 37:1434-43. 2009
    ..of studies on the prevalence of osteoarthritis in the tibiofemoral joint more than 10 years after an anterior cruciate ligament injury, the radiologic classification methods used, and risk factors for development of knee osteoarthritis.
  57. ncbi Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
    Carl Johan Tiderius
    Department of Orthopedics, Diagnostic Radiology and Radiation Physics, Malmo University Hospital, Lund University, Sweden
    Magn Reson Med 49:488-92. 2003
    ..5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr...
  58. ncbi Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking
    Annegret Mundermann
    Stanford University Medical Center, Stanford, California 94305 4038, USA
    Arthritis Rheum 52:2835-44. 2005
    This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip.
  59. ncbi Clinical practice. Osteoarthritis of the knee
    David T Felson
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 354:841-8. 2006
  60. ncbi Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis
    Raveendhara R Bannuru
    Tufts University School of Medicine, Boston, MA, USA
    Arthritis Rheum 61:1704-11. 2009
    To compare the efficacy of intraarticular hyaluronic acid with corticosteroids for knee osteoarthritis (OA).
  61. ncbi Hip strengthening reduces symptoms but not knee load in people with medial knee osteoarthritis and varus malalignment: a randomised controlled trial
    K L Bennell
    Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, University of Melbourne, Australia
    Osteoarthritis Cartilage 18:621-8. 2010
    ..To determine whether hip abductor and adductor muscle strengthening reduces medial compartment knee load and improves symptoms in people with medial tibiofemoral OA and varus malalignment...
  62. ncbi Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis
    Florent Richy
    Faculty of Medicine, Department of Public Health, Public Health and Epidemiology, University of Liege, Liege, Belgium
    Arch Intern Med 163:1514-22. 2003
    To assess the structural and symptomatic efficacy of oral glucosamine sulfate and chondroitin sulfate in knee osteoarthritis through independent meta-analyses of their effects on joint space narrowing, Lequesne Index, Western Ontario ..
  63. ncbi Performance-based methods for measuring the physical function of patients with osteoarthritis of the hip or knee: a systematic review of measurement properties
    C B Terwee
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Rheumatology (Oxford) 45:890-902. 2006
    ..e. internal consistency, reproducibility, validity, responsiveness and interpretability) of all performance-based methods which have been used to measure the physical function of patients with osteoarthritis of the hip or knee...
  64. ncbi OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence
    W Zhang
    University of Edinburgh, Osteoarticular Research Group, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Osteoarthritis Cartilage 15:981-1000. 2007
    ..developing updated, evidence-based, international consensus recommendations for the management of hip and knee osteoarthritis (OA), the Osteoarthritis Research Society International (OARSI) Treatment Guidelines Committee undertook a ..
  65. ncbi Effectiveness of aquatic exercise for obese patients with knee osteoarthritis: a randomized controlled trial
    Jae Young Lim
    Department of Rehabilitation, Seoul National University College of Medicine, Seoul National University Bundang Hospital 300, Gumi dong, Bundang gu, Seongnam si, Gyeonggi do 463 707, Republic of Korea
    PM R 2:723-31; quiz 793. 2010
    ..land-based exercise (LBE) program to enhance knee function and reduce body fat in patients with obesity and knee osteoarthritis and to investigate the effectiveness of AQE and LBE on body fat, functional fitness, and functional status.
  66. ncbi Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China
    Hui Du
    Department of Rheumatology and Clinical Immunology, Ren Ji Hospital, No 2 Medical University, Shanghai, China 200001
    Rheumatol Int 25:585-90. 2005
    A community-based survey on the prevalence of knee osteoarthritis (OA) and associated factors was carried out in Shanghai, People's Republic of China.
  67. pmc Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study
    Gregory Livshits
    King s College London, London, UK
    Arthritis Rheum 60:2037-45. 2009
    ....
  68. ncbi Validity and reliability of functional performance tests in meniscectomized patients with or without knee osteoarthritis
    A B Bremander
    Department of Orthopedics, Lund University, Lund, Sweden
    Scand J Med Sci Sports 17:120-7. 2007
    Reduced functional performance and muscular dysfunction after knee injury and in knee osteoarthritis (OA) is suggested to be a factor in OA development...
  69. ncbi Validation of American College of Rheumatology classification criteria for knee osteoarthritis using arthroscopically defined cartilage damage scores
    Christopher W Wu
    University of California at San Diego, La Jolla, CA 92037, USA
    Semin Arthritis Rheum 35:197-201. 2005
    ..To validate the ability of the American College of Rheumatology (ACR) clinical classification criteria and the ACR clinical plus radiographic classification criteria for osteoarthritis of the knee to predict articular cartilage damage...
  70. ncbi Gait and muscle activation changes in men with knee osteoarthritis
    Tuomas Liikavainio
    Department of Physical and Rehabilitation Medicine, Kuopio University Hospital, P O Box 1777, FIN 70211, Kuopio, Finland
    Knee 17:69-76. 2010
    The aim was to examine the biomechanics of level- and stair-walking in men with knee osteoarthritis (OA) at different pre-determined gait speeds and to compare the results with those obtained from healthy control subjects...
  71. pmc EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility
    P Conaghan
    Rheumatology Department, Cochin Hospital, 27, rue du Faubourg St Jacques, 75014 Paris, France
    Ann Rheum Dis 64:1710-4. 2005
    ..Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression...
  72. ncbi C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study
    G Engstrom
    AstraZeneca R and D, Lund, Sweden
    Osteoarthritis Cartilage 17:168-73. 2009
    ..To explore the relationships between C-reactive protein (CRP), metabolic syndrome (MetS) and incidence of severe knee or hip osteoarthritis (OA) in a prospective study...
  73. ncbi Measuring the population impact of knee pain and disability with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
    Clare Jinks
    Primary Care Sciences Research Centre, Hornbeam Building, Keele University, Keele, Staffordshire ST5 5BG, UK
    Pain 100:55-64. 2002
    ..Chronicity, older age, injury, obesity and depression were all linked with higher WOMAC scores for knee pain severity and disability among knee pain sufferers in the general older population...
  74. ncbi Aquatic physical therapy for hip and knee osteoarthritis: results of a single-blind randomized controlled trial
    Rana S Hinman
    Centre for Health Exercise and Sports Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Phys Ther 87:32-43. 2007
    Aquatic physical therapy is frequently used in the management of patients with hip and knee osteoarthritis (OA), yet there is little research establishing its efficacy for this population...
  75. pmc Physical therapists' use of therapeutic exercise for patients with clinical knee osteoarthritis in the United kingdom: in line with current recommendations?
    Melanie A Holden
    Arthritis Research Campaign National Primary Care Centre, Keele University, Staffordshire, United Kingdom
    Phys Ther 88:1109-21. 2008
    Physical therapists have an important role in the management of clinical knee osteoarthritis (OA) through designing and supervising exercise programs...
  76. pmc Quantifying the pain experience in hip and knee osteoarthritis
    Rajiv Gandhi
    Division of Orthopedic Surgery, University of Toronto, Toronto, Ontario, Canada
    Pain Res Manag 15:224-8. 2010
    The present study investigated whether the conceptualization of hip and knee osteoarthritis pain implicit in the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Medical Outcomes Study Short-Form 36 (SF-36) scales is ..
  77. ncbi Case-control study of knee osteoarthritis and lifestyle factors considering their interaction with physical workload
    Ilias Vrezas
    Cyprus International Institute for Environmental and Public Health in Association with Harvard School of Public Health, Cyprus University of Technology, Lemesos, Cyprus
    Int Arch Occup Environ Health 83:291-300. 2010
    ..relationships between age, "lifestyle factors" (body mass index, tobacco smoking, sports), and symptomatic knee osteoarthritis in a population-based case-control study...
  78. ncbi The influence of foot progression angle on the knee adduction moment during walking and stair climbing in pain free individuals with knee osteoarthritis
    Mengtao Guo
    Center for Biomedical Engineering Research, Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, United States
    Gait Posture 26:436-41. 2007
    ..magnitude of the adduction moment is associated with the development and progression of medial compartment knee osteoarthritis (OA)...
  79. ncbi Land-based exercise for osteoarthritis of the knee: a metaanalysis of randomized controlled trials
    Marlene Fransen
    The George Institute, University of Sydney, PO Box M201 Missenden Road, Camperdown NSW 2050, Australia
    J Rheumatol 36:1109-17. 2009
    To determine if clinical guidelines recommending therapeutic exercise for people with knee osteoarthritis (OA) are supported by rigorous scientific evidence...
  80. ncbi How do middle-aged patients conceive exercise as a form of treatment for knee osteoarthritis?
    Carina A Thorstensson
    Spenshult Hospital for Rheumatic Diseases, Halmstead, Sweden
    Disabil Rehabil 28:51-9. 2006
    To describe conceptions, as registered by a semi-structured interview, of exercise as treatment among sixteen middle-aged patients with moderate to severe knee osteoarthritis.
  81. ncbi Epidemiology of hip and knee pain and its impact on overall health status in older adults
    J Dawson
    Oxford Centre for Health Care Research and Development, School of Health and Social Care, Oxford Brookes University, UK
    Rheumatology (Oxford) 43:497-504. 2004
    ..To obtain prevalence rates of hip and knee pain in elderly people and compare combinations of symptoms with overall health status...
  82. ncbi Hip muscle weakness in individuals with medial knee osteoarthritis
    Rana S Hinman
    University of Melbourne, Australia
    Arthritis Care Res (Hoboken) 62:1190-3. 2010
    To compare the strength of the hip musculature in people with symptomatic medial knee osteoarthritis (OA) with asymptomatic controls.
  83. ncbi A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis
    C Thomas Vangsness
    Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Arthroscopy 25:86-94. 2009
    ..The excellent safety profile of glucosamine and chondroitin sulfate therapy should be discussed with patients, and these supplements may serve a role as an initial treatment modality for many OA patients...
  84. ncbi Supplementing a home exercise programme with a class-based exercise programme is more effective than home exercise alone in the treatment of knee osteoarthritis
    C J McCarthy
    The Centre for Rehabilitation Science, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Rheumatology (Oxford) 43:880-6. 2004
    ..the relative effectiveness of providing a home-based exercise programme versus home-based exercise supplemented with an 8-week class-based exercise programme in reducing pain and improving function in patients with knee osteoarthritis.
  85. pmc Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention
    F Angst
    Clinic of Rheumatology and Rehabilitation Zurzach, Switzerland
    Ann Rheum Dis 60:834-40. 2001
    ....
  86. ncbi Contribution of psychosocial and mechanical variables to physical performance measures in knee osteoarthritis
    Monica R Maly
    Elborn College, School of Physical Therapy, The University of Western Ontario, London, Ontario, Canada N6G 1H1
    Phys Ther 85:1318-28. 2005
    This cross-sectional study evaluated the relative contributions of psychosocial and mechanical variables to physical performance measures in people with knee osteoarthritis (OA).
  87. pmc The evolving role of obesity in knee osteoarthritis
    MaryFran R Sowers
    Department of Epidemiology, Unversity of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Curr Opin Rheumatol 22:533-7. 2010
    The frequency of knee osteoarthritis continues to accelerate, likely because of the increasing proliferation of obesity, particularly in men and women 40-60 years of age at the leading edge of the 'baby boom' demographic expansion...
  88. ncbi Effects of footwear on medial compartment knee osteoarthritis
    Meika A Fang
    Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    J Rehabil Res Dev 43:427-34. 2006
    ..shoes altered joint pain, stiffness, and physical function in patients with symptomatic medial compartment knee osteoarthritis (OA)...
  89. ncbi Optimal stimulation frequency of transcutaneous electrical nerve stimulation on people with knee osteoarthritis
    Pearl P W Law
    Physiotherapy Department, Chi Lin Care and Attention Home, Hong Kong
    J Rehabil Med 36:220-5. 2004
    This is a double blind study that examined the optimal stimulation frequency of transcutaneous electrical nerve stimulation in reducing pain due to knee osteoarthritis.
  90. ncbi Acupuncture treatment for chronic knee pain: a systematic review
    A White
    Peninsula Medical School, Universities of Exeter and Plymouth, Plymouth, UK
    Rheumatology (Oxford) 46:384-90. 2007
    ..To evaluate the effects of acupuncture on pain and function in patients with chronic knee pain...
  91. ncbi The efficacy of home based progressive strength training in older adults with knee osteoarthritis: a randomized controlled trial
    K R Baker
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Rheumatol 28:1655-65. 2001
    ..CONCLUSION: High intensity, home based strength training can produce substantial improvements in strength, pain, physical function and quality of life in patients with knee OA...
  92. ncbi Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis
    D Schiphof
    Erasmus MC, Department of General Practice, Rotterdam, The Netherlands
    Ann Rheum Dis 67:1034-6. 2008
    ..We summarised different descriptions and searched for evidence on the impact of such variations on classification of knee osteoarthritis (OA) in epidemiological studies.
  93. ncbi Thrust during ambulation and the progression of knee osteoarthritis
    Alison Chang
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:3897-903. 2004
    ....
  94. ncbi Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis
    Ana M Valdes
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
    Arthritis Rheum 62:2347-52. 2010
    ..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans...
  95. ncbi The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
    Daisuke Seino
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    Pain 123:193-203. 2006
    ..Thus, it is suggested that the activation of the P2X3 receptor is involved in the phosphorylation of ERK in DRG neurons and the mechanical hypersensitivity of the inflamed knee joint...
  96. ncbi Self-reported physical functioning was more influenced by pain than performance-based physical functioning in knee-osteoarthritis patients
    Caroline B Terwee
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    J Clin Epidemiol 59:724-31. 2006
    ..To test the hypothesis that self-reported physical functioning is more influenced by pain than performance-based physical functioning...
  97. ncbi Effectiveness of a home-based exercise therapy and walking program on osteoarthritis of the knee
    Deniz Evcik
    Kocatepe University, School of Medicine, Department of Physical Medicine and Rehabilitation, 03200 Afyon, Turkey
    Rheumatol Int 22:103-6. 2002
    ..A total of 90 patients with knee osteoarthritis were included. Their ages ranged between 48 and 71 years. The patients were separated into three groups...
  98. pmc Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
    Tuhina Neogi
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    BMJ 339:b2844. 2009
    ..To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts...
  99. ncbi Recommendations for the treatment of knee osteoarthritis, using various therapy techniques, based on categorizations of a literature review
    Anthony Thomas
    Rockhurst University, Department of Physical Therapy, Kansas City, MO 64110, USA
    J Geriatr Phys Ther 32:33-8. 2009
    ..This article provides a systematic categorization as well as recommendations for physical therapists based on current (1996 or sooner) literature...
  100. ncbi Tai Chi Qigong for the quality of life of patients with knee osteoarthritis: a pilot, randomized, waiting list controlled trial
    Hwa Jin Lee
    Acupuncture and Meridian Science Research Center AMSRC, Kyung Hee University, Seoul and Department of Meridian and Acupoint, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
    Clin Rehabil 23:504-11. 2009
    ..To evaluate the effects of Tai Chi Qigong training on the quality of life and physical function of patients with osteoarthritis of the knee...
  101. ncbi Long-term outcome of meniscectomy: symptoms, function, and performance tests in patients with or without radiographic osteoarthritis compared to matched controls
    E M Roos
    Institute of Musculoskeletal Disease, Department of Orthopedics, Lund University, Sweden
    Osteoarthritis Cartilage 9:316-24. 2001
    ..To describe the long-term influence of meniscectomy on pain, functional limitations, and muscular performance. To assess the effects of radiographic osteoarthritis (OA), gender and age on these outcomes in patients with meniscectomy...

Research Grants72

  1. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    Traditional exercise therapy programs for knee osteoarthritis (OA) primarily focus on addressing lower extremity strength and joint motion deficits and have yielded fair to moderate improvements in functional status...
  2. (BOAMRI) Biomarkers in Osteoarthritis MRI Studies
    David Felson; Fiscal Year: 2006
    ..We plan to conduct small-scale studies within existing longitudinal datasets of knee osteoarthritis studies to evaluate and validate promising biomarkers...
  3. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ....
  4. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..Thus, in addition to this study providing a potential paradigm shift in our thinking regarding the "disease" of OA, this study also develops practical clinical tools for identifying the presence of centrally-enhanced pain in OA. ..
  5. Motivational Interviewing and Physical Activity Behavior Change in Arthritis
    Linda Ehrlich-Jones; Fiscal Year: 2012
    ..focuses on increasing lifestyle physical activity in persons with rheumatoid arthritis (RA) and knee osteoarthritis (OA)...
  6. Collider Bias and the Risk Factor Paradoxes in Rheumatic Disease Research
    UYEN SA DUC TRAN NGUYEN; Fiscal Year: 2013
    ..Rheumatic conditions and their sequelae, including rheumatoid arthritis (RA), psoriatic arthritis, and knee osteoarthritis (OA), constitute a tremendous disease burden in the US and worldwide...
  7. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is a major cause of disability among Veterans and is the primary indication of knee replacement in the VA...
  8. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..g. knee) osteoarthritis. The benefits of this research will be more informed, safer and more effective prescriptions of walking as exercise for weight management and cardiovascular health. ..
  9. Biological Markers of System Burden in Symptomatic Knee OA: A Prospective Study
    KIMBERLY THERESA SIBILLE; Fiscal Year: 2013
    ..the effects of stress on health, and the application of the allostatic load model in the study of knee osteoarthritis. My transition to research independence will also be benefited by relationships developed in the OA Network,..
  10. JointADventure: A Worksite Activity-Diet Intervention for Chronic Knee Pain
    Rowland W Chang; Fiscal Year: 2013
    ..disability and its associated costs will significantly worsen, largely due to the consequences of knee osteoarthritis (OA)...
  11. Patient Oriented Research and Mentoring Program in Orthopedics
    Elena Losina; Fiscal Year: 2013
    ..the diagnostic value of clinical history for the diagnosis of symptomatic meniscal tears in the presence of knee osteoarthritis (OA)...
  12. Tai Chi for Knee Osteoarthritis
    Chenchen Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) causes pain and long-term disability and costs the US more than $65 billion per year. The impact will increase as the population ages...
  13. Enhancing the Effectiveness of Physical Therapy in People with Knee OA
    G Kelley Fitzgerald; Fiscal Year: 2013
    ..therapy (ET) is effective as the first line of treatment for reducing pain and disability in patients with knee osteoarthritis (OA), but studies show its effects diminish considerably over time...
  14. MR Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
    Bradley Foerster; Fiscal Year: 2013
    ..of a reliable strategy for differentiation of central pain predominant from peripheral pain predominant knee osteoarthritis (KOA), chronic low back pain (CLBP) and painful diabetic neuropathy (DPN) patients using clinical features, ..
  15. Vitamin K, Knee Osteoarthritis, and Physical Function in Older Adults
    Richard F Loeser; Fiscal Year: 2013
    ....
  16. Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
    Tuhina Neogi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is the leading cause of lower extremity disability among older adults in the United States...
  17. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2012
    ....
  18. Multicenter Osteoarthritis Study (MOST) Renewal
    Michael C Nevitt; Fiscal Year: 2013
    ..This proposal introduces four new approaches into the epidemiologic study of knee osteoarthritis: l.a focus on symptomatic disease, 2...
  19. Dynamic Instability in Persons with Knee Osteoarthritis
    Leena Sharma; Fiscal Year: 2012
    ..This is a key, modifiable component of the knee joint environment that has received little attention in knee OA, despite a potentially large role for stability in the preservation of knee joint integrity and person-level functioning. ..
  20. Strength Training and Arthritis Trial
    Stephen P Messier; Fiscal Year: 2013
    ..Quadriceps muscle strength loss contributes directly to the pain, disability and morbidity associated with knee osteoarthritis (OA). Strength loss of up to 40% typically occurs and may actually precede the development of knee OA...
  21. Knee Osteoarthritis: Meniscus Kinematics and Articular Cartilage Degeneration
    Toran D MacLeod; Fiscal Year: 2013
    ..The research-training program includes course work in designing and implementing clinical research, a rich research environment, and structured mentoring for the applicant. ..
  22. Early NMES to Improve Quadriceps Muscle Function After Total Knee Arthroplasty
    Jennifer E Stevens-Lapsley; Fiscal Year: 2012
    ..While TKA reliably reduces pain and improves function in older adults with knee osteoarthritis, the recovery of force and function to normal levels is rare, which predisposes patients to future ..
  23. Inflammation and Knee Osteoarthritis
    Cora E Lewis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Symptomatic knee osteoarthritis (OA) affects 6% of the U.S. adult population and 12-13% of those ages 60 and over...
  24. Determination of pain phenotypes in older adults with knee osteoarthritis
    Jennifer E Stevens-Lapsley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) affects 12% of older adults (4.3 million Americans) and contributes to diminished physical function, poor quality of life, and reduced life expectancy...
  25. Midcareer investigator award in patient oriented research (K24)
    Nancy E Lane; Fiscal Year: 2013
    ..investigator conducting research on the epidemiology and genetics of prevalent and progression of hip and knee osteoarthritis. The purpose of this K24 award renewal is to continue to mentor and teach clinical research in ..
  26. Group Physical Therapy for Veterans with Knee Osteoarthritis
    Kelli D Allen; Fiscal Year: 2013
    Project Summary Knee osteoarthritis (OA) is one of the most common health problems and a leading cause of disability among veterans...
  27. Rapid MRI Method of Assessing Joint Degeneration
    Walter F Block; Fiscal Year: 2012
    ..develop a rapid MR imaging method for evaluating all joint structures which can cause pain in patients with knee osteoarthritis (OA). Our single imaging method will replace multiple imaging methods currently used in OA research studies...
  28. Ethnic Differences in Responses to Painful Stimuli
    Roger B Fillingim; Fiscal Year: 2013
    ..clinical pain and pain-related disability among older African Americans and non-Hispanic whites with knee osteoarthritis (OA)...
  29. TAS::75 0888::TAS BIOMEDICAL (APPLIED/EXPLORATORY)
    Kent Kwoh; Fiscal Year: 2010
    ..e., surrogate biomarkers) that precede the onset of radiographic knee osteoarthritis (ROA) and/or that predict the development of important clinical outcomes...
  30. Contact mechanics, neuromuscular control, and cartilage composition in knee OA
    RICHARD BRIAN SOUZA; Fiscal Year: 2013
    ..Mechanical loading during daily activities plays a critical role in the onset and progression of knee osteoarthritis (OA)...
  31. TAS::75 0888::TAS
    Charles B Eaton; Fiscal Year: 2010
    ..biobehavioral, dietary, pharmacologic and CAM therapies on improving patient centered outcomes related to knee osteoarthritis several analytic issues arise when evaluating epidemiological data...
  32. Can Neuromuscular Training Alter Movement Patterns?
    Lynn Snyder-Mackler; Fiscal Year: 2013
    ..Cruciate ligament injury and surgery are common;recovery is not simple and disability, particularly from knee osteoarthritis happens often in the years following the injury...
  33. Study of Physical Activity Rewards after Knee Surgery (SPARKS)
    Elena Losina; Fiscal Year: 2013
    ..provided by applicant): Physical activity (PA) has been shown to improve pain and function in persons with knee osteoarthritis (OA), reduce obesity, and prevent the onset and progression of heart disease, diabetes, and chronic ..
  34. Clinical impact and cost-effectiveness of pain management in knee OA
    Elena Losina; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Symptomatic knee osteoarthritis (OA) is highly prevalent, disabling and costly. Pain related to knee OA is the principal driver of disability associated with this condition and attendant costs...
  35. Sex differences in ACL injury risk factors emerge during adolescent growth
    KEVIN RAY FORD; Fiscal Year: 2012
    ..ACL injured patients, long term outcome studies show that these patients are at a high risk for developing knee osteoarthritis 10-15 years after ACL injury regardless of the treatment...
  36. Multicenter Osteoarthritis Study (MOST) Renewal
    DAVID TOBIN FELSON; Fiscal Year: 2013
    ..Symptomatic knee osteoarthritis affects 12% of elders and despite medical advances, remains, for many affected, a major source of pain and ..
  37. Progressive Rehabilitation for Total Knee Arthroplasty
    Jennifer E Stevens-Lapsley; Fiscal Year: 2013
    ..TKAs) are performed each year in the United States to alleviate pain and disability associated with knee osteoarthritis (OA), and this number is expected to grow to 3.48 million per year by the year 2030...
  38. Optimizing Couple-Oriented Interventions for Chronic Illness
    Lynn M Martire; Fiscal Year: 2013
    ..couple-level characteristics that moderate these processes, using dyadic diary data collected in studies of knee osteoarthritis and Type 2 diabetes...
  39. Clinical Centers for the Osteoarthritis Initiative[unreadable]Rhode Island
    Charles B Eaton; Fiscal Year: 2010
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  40. Pain Mechanisms and Outcomes in Osteoarthritis
    Kristine Phillips; Fiscal Year: 2013
    ..and/or diffuse pain on a body pain diagram 2) To show that experimental pain testing will identify knee osteoarthritis patients with a significant central pain contribution based on findings of either widespread hyperalgesia ..
  41. Pain Mechanisms of Knee Joint Osteoarthritis
    HEE JEONG IM SAMPEN; Fiscal Year: 2013
    ..mechanisms, 2) genetically modified mice to understand pathophysiological nociceptive pathway evoked by knee osteoarthritis, and 3) investigation of peripheral (dorsal root ganglions) and central (spinal dorsal horn) responses by ..
  42. OSTEOARTHRITIS INITIATIVE DATA COORDINATING CENTER
    Susan Rubin; Fiscal Year: 2012
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  43. Biobehavioral Risk Factors for Persistent Pain following Total Knee Arthroplasty
    Robert R Edwards; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Degenerative joint disease, particularly knee osteoarthritis (OA), is one of the most prevalent and disabling chronic pain conditions and is projected to increase sharply as the U.S. population ages...
  44. Predicting Post-Operative Pain and Analgesic Use: The Role of Endogenous Opioids
    CLAUDIA MICHELLE CAMPBELL; Fiscal Year: 2013
    ..in predicting pain and opioid analgesic use following total knee arthroplasty (TKA) in patients with knee osteoarthritis (OA), one of the most prevalent chronic pain conditions and predicted to drastically increase as the U.S...
  45. Data Coordinating Center for the Osteoarthritis Initiative
    Michael Nevitt; Fiscal Year: 2011
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  46. Clinical Centers for the Osteoarthritis Initiative
    Marc Hochberg; Fiscal Year: 2010
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  47. Clinical Centers for the Osteoarthritis Initiative
    Rebecca Jackson; Fiscal Year: 2010
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  48. Clinical Centers for the Osteoarthritis Initiative
    Marc Hochberg; Fiscal Year: 2011
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  49. Clinical Centers for the Osteoarthritis Initiative
    Rebecca Jackson; Fiscal Year: 2009
    b>Knee osteoarthritis (OA) is the most common cause of disability in adults...
  50. Modifiable Risk Factors for Incident and Progressive Early Knee Osteoarthritis
    Grace Lo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): From a convenience perspective, many knee osteoarthritis (OA) studies have focused on those with moderate to severe disease because the natural history of OA occurs over years...
  51. A network meta-analysis of pharmacological interventions for knee osteoarthritis
    RAVEENDHARA REDDY BANNURU; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is the most frequent cause of joint replacement and of early retirement. It therefore has considerable economic and societal costs...
  52. New Investigator Workshop on Advancing Arthritis Research
    Julie J Keysor; Fiscal Year: 2013
    ..First, speakers will review large publically available epidemiological datasets on knee osteoarthritis and possible clinical research questions that can be addressed using large epidemiological databases...
  53. Analysis of single-bundle versus double-bundle technique in ACL reconstruction
    Samuel K Van de Velde; Fiscal Year: 2010
    ..of age, and is clinically associated with an increased incidence, earlier onset, and faster progression of knee osteoarthritis. Even a small increment of improvement in function would be valuable for this active population...
  54. Knee OA: Predictors and Outcomes of Physical Inactivity-Activity Transitions
    Dorothy D Dunlop; Fiscal Year: 2013
    ..by applicant): This study investigates an expanded paradigm to improve health outcomes for adults with knee osteoarthritis (OA), through changes in the low end of the physical activity spectrum where much of the knee OA population ..
  55. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..musculoskeletal condition in our active military personnel, and a causative factor for the development of knee osteoarthritis in our aging veteran populations...
  56. The Effect of Exercise on Progression of Knee OA
    ANDREW CONCOFF; Fiscal Year: 2003
    ..of knee OA than a control group that receives only education regarding self-management techniques in knee osteoarthritis. A novel, arthroscopic outcome measure that assesses cartilage damage and synovial inflammation, the ..
  57. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Symptomatic knee osteoarthritis affects 6% of the U.S. adult population and 12-13% of those age 60 and over (Felson and Zhang, 1998)...
  58. Ethnicity, Gender & Social Support in Knee Osteoarthritis
    HUAN CHANG; Fiscal Year: 2007
    ..She will continue to submit grant applications to support these ideas. In patients with severe knee osteoarthritis (CA), total knee replacement (TKR) relieves chronic pain, restores lost function, and is cost- effective...
  59. The Relationship of n-3 Fatty Acids with Pain and Synovium in knee OA
    Kristin Baker; Fiscal Year: 2009
    ..In the research plan we propose to investigate a potential nutrition therapy for synovitis and pain in knee osteoarthritis. There is now much evidence indicating subclinical inflammation in osteoarthritis (OA), even in the absence ..
  60. TIDAL LAVAGE VS SHAM LAVAGE IN KNEE OSTEOARTHRITIS
    John Bradley; Fiscal Year: 1999
    ..Inclusion of the QWB will allow assessment of the cost-utility of TL. The investigators state that the results of this study will carry important implications for health policy decisions and reimbursement determinations. ..
  61. Aerobic Exercise Intervention for Knee Osteoarthritis
    Kenton Kaufman; Fiscal Year: 2005
    ..The focus of this study is to determine if these guidelines can also be applied to individuals with knee osteoarthritis. Patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a ..
  62. A Pharmacokinetic Study of glucosamine and chondroitin
    Christopher Jackson; Fiscal Year: 2005
    ..to determine the efficacy of glucosamine, chondroitin, and the combination in relieving the symptoms of knee osteoarthritis and to investigate the possibility of a chondroprotective effect...