osteoarthritis

Summary

Summary: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Top Publications

  1. pmc Burden of major musculoskeletal conditions
    Anthony D Woolf
    Peninsula Medical School, Duke of Cornwall Department of Rheumatology, Royal Cornwall Hospital, Truro TR1 3LJ, England
    Bull World Health Organ 81:646-56. 2003
  2. pmc Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
    Eleftheria Zeggini
    Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Lancet 380:815-23. 2012
  3. pmc Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    Reva C Lawrence
    NIH, Bethesda, Maryland, USA
    Arthritis Rheum 58:26-35. 2008
  4. ncbi Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
    Mohit Kapoor
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    Nat Rev Rheumatol 7:33-42. 2011
  5. pmc The role of synovitis in osteoarthritis pathogenesis
    Carla R Scanzello
    Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Bone 51:249-57. 2012
  6. ncbi Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
    F Berenbaum
    University Pierre and Marie Curie, Paris VI, Sorbonne Universités, 7 quai St Bernard, 75252 Cedex 5 Paris, France
    Osteoarthritis Cartilage 21:16-21. 2013
  7. ncbi Metabolic syndrome meets osteoarthritis
    Qi Zhuo
    Department of Orthopaedics, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, People s Republic of China
    Nat Rev Rheumatol 8:729-37. 2012
  8. ncbi American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
    Marc C Hochberg
    Division of Rheumatology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 8 34, Baltimore, MD 21201, USA
    Arthritis Care Res (Hoboken) 64:465-74. 2012
  9. pmc Inflammation in osteoarthritis
    Mary B Goldring
    Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
    Curr Opin Rheumatol 23:471-8. 2011
  10. ncbi A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis
    Yoshinari Miyamoto
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 39:529-33. 2007

Detail Information

Publications329 found, 100 shown here

  1. pmc Burden of major musculoskeletal conditions
    Anthony D Woolf
    Peninsula Medical School, Duke of Cornwall Department of Rheumatology, Royal Cornwall Hospital, Truro TR1 3LJ, England
    Bull World Health Organ 81:646-56. 2003
    ..This paper describes the burden of four major musculoskeletal conditions: osteoarthritis, rheumatoid arthritis, osteoporosis, and low back pain...
  2. pmc Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
    Eleftheria Zeggini
    Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Lancet 380:815-23. 2012
    b>Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity...
  3. pmc Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    Reva C Lawrence
    NIH, Bethesda, Maryland, USA
    Arthritis Rheum 58:26-35. 2008
    ..a single source for the best available estimates of the US prevalence of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as ..
  4. ncbi Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
    Mohit Kapoor
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada
    Nat Rev Rheumatol 7:33-42. 2011
    b>Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane, although the etiology and pathogenesis underlying this debilitating disease are poorly understood...
  5. pmc The role of synovitis in osteoarthritis pathogenesis
    Carla R Scanzello
    Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Bone 51:249-57. 2012
    Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-articular bone, but there is increasing recognition that OA affects all of the joint tissues, including the synovium (SM)...
  6. ncbi Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
    F Berenbaum
    University Pierre and Marie Curie, Paris VI, Sorbonne Universités, 7 quai St Bernard, 75252 Cedex 5 Paris, France
    Osteoarthritis Cartilage 21:16-21. 2013
    b>Osteoarthritis (OA) has long been considered a "wear and tear" disease leading to loss of cartilage...
  7. ncbi Metabolic syndrome meets osteoarthritis
    Qi Zhuo
    Department of Orthopaedics, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, People s Republic of China
    Nat Rev Rheumatol 8:729-37. 2012
    Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links have been discovered between this phenotype and metabolic syndrome (MetS)--both with individual MetS components and with MetS as a whole...
  8. ncbi American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
    Marc C Hochberg
    Division of Rheumatology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 8 34, Baltimore, MD 21201, USA
    Arthritis Care Res (Hoboken) 64:465-74. 2012
    To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA.
  9. pmc Inflammation in osteoarthritis
    Mary B Goldring
    Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
    Curr Opin Rheumatol 23:471-8. 2011
    This review focuses on the novel stress-induced and proinflammatory mechanisms underlying the pathogenesis of osteoarthritis, with particular attention to the role of synovitis and the contributions of other joint tissues to cellular ..
  10. ncbi A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis
    Yoshinari Miyamoto
    Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Genet 39:529-33. 2007
    b>Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide...
  11. ncbi Osteoarthritis: epidemiology
    Nigel Arden
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Best Pract Res Clin Rheumatol 20:3-25. 2006
    b>Osteoarthritis (OA) is the most common joint disorder in the world. In Western populations it is one of the most frequent causes of pain, loss of function and disability in adults...
  12. ncbi GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
    Melina Daans
    Department of Musculoskeletal Sciences, Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann Rheum Dis 70:208-13. 2011
    ..levels of growth and differentiation factor 5 (GDF5) was recently identified as a susceptibility factor for osteoarthritis. The authors studied the potential mechanisms of GDF5 involvement in osteoarthritis using haploinsufficient ..
  13. ncbi Subchondral bone as a key target for osteoarthritis treatment
    Santos Castañeda
    Department of Rheumatology, Hospital de la Princesa, IIS Princesa, Universidad Autonoma, Madrid, Spain
    Biochem Pharmacol 83:315-23. 2012
    b>Osteoarthritis (OA), the most common form of arthritis, is a debilitating and progressive disease that has become a major cause of disability and impaired quality of life in the elderly...
  14. ncbi Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 49:47-57. 2012
    Aneurysms-osteoarthritis syndrome (AOS) is a new autosomal dominant syndromic form of thoracic aortic aneurysms and dissections characterised by the presence of arterial aneurysms and tortuosity, mild craniofacial, skeletal and cutaneous ..
  15. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    ..More importantly the extent to which pain interferes with everyday life increases incrementally with age up to the oldest age-group in the community-dwelling general population...
  16. ncbi Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 43:121-6. 2011
    ..In contrast with other aneurysm syndromes, most of these affected individuals presented with early-onset osteoarthritis. We mapped the genetic locus to chromosome 15q22.2-24...
  17. ncbi Osteoarthritis year 2010 in review: pathomechanisms
    W B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Med Center RUNMC, The Netherlands
    Osteoarthritis Cartilage 19:338-41. 2011
    b>Osteoarthritis is characterized by progressive breakdown of articular cartilage. This review summarizes findings of the last year, which shed new light on mechanisms and factors involved in cartilage loss...
  18. ncbi Bone remodelling in osteoarthritis
    David B Burr
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Rev Rheumatol 8:665-73. 2012
    The classical view of the pathogenesis of osteoarthritis (OA) is that subchondral sclerosis is associated with, and perhaps causes, age-related joint degeneration...
  19. pmc Identification of a central role for complement in osteoarthritis
    Qian Wang
    Geriatric Research Education and Clinical Centers, Veteran s Affairs Palo Alto Health Care System, Palo Alto, California, USA
    Nat Med 17:1674-9. 2011
    b>Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of 'wear and tear'. Although low-grade inflammation is detected in osteoarthritis, its role is unclear...
  20. pmc Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
    Rita Dreier
    University Hospital of Munster, Institute for Physiological Chemistry and Pathobiochemistry, Waldeyerstra e 15, 48149 Munster, Germany
    Arthritis Res Ther 12:216. 2010
    b>Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to loss of joint function. The molecular mechanisms regulating pathogenesis and progression of osteoarthritis are poorly understood...
  21. pmc Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
    Dimitrios Iliopoulos
    Institute of Biomedical Research and Technology, Larissa, Greece
    PLoS ONE 3:e3740. 2008
    b>Osteoarthritis is a multifactorial disease characterized by destruction of the articular cartilage due to genetic, mechanical and environmental components affecting more than 100 million individuals all over the world...
  22. ncbi Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
    ..that produce increased load transfer or altered patterns of load distribution accelerate the development of osteoarthritis (OA)...
  23. ncbi Osteoarthritis cartilage histopathology: grading and staging
    K P H Pritzker
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Osteoarthritis Cartilage 14:13-29. 2006
    Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity...
  24. pmc EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 66:377-88. 2007
    To develop evidence based recommendations for the management of hand osteoarthritis (OA).
  25. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Future directions in the research and treatment of osteoarthritis (OA) will be based on the emerging picture of pathophysiological events that modulate the initiation and ..
  26. ncbi Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    Taku Saito
    Sensory and Motor System Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Nat Med 16:678-86. 2010
    ..factor (VEGF), respectively, are central steps of endochondral ossification during normal skeletal growth and osteoarthritis development...
  27. ncbi Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis
    C Karlsson
    Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden v
    Osteoarthritis Cartilage 18:581-92. 2010
    ..is the functional element in articular cartilage and its degradation is central in the pathogenetic process in osteoarthritis (OA), increasing the knowledge about the cellular OA phenotype is essential...
  28. ncbi The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review
    D Pereira
    Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Portugal
    Osteoarthritis Cartilage 19:1270-85. 2011
    To understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints.
  29. ncbi An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
    Lorraine Southam
    Botnar Research Centre, University of Oxford, UK
    Hum Mol Genet 16:2226-32. 2007
    A compelling genetic association with osteoarthritis (OA) of a functional SNP (rs143383, T/C) in the 5'-UTR of the GDF5 gene was recently reported in case-control cohorts from Japan and China. GDF5 is a pro-chondrogenic growth factor...
  30. pmc Differential genetic regulation of canine hip dysplasia and osteoarthritis
    Zhengkui Zhou
    College of Animal Science and Technology, Northwest A and F University, Yangling, China
    PLoS ONE 5:e13219. 2010
    Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.
  31. ncbi The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
    Jeremie Sellam
    Pierre and Marie Curie University, Department of Rheumatology, AP HP Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, Paris 75012, France
    Nat Rev Rheumatol 6:625-35. 2010
    b>Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain...
  32. ncbi Cartilage in normal and osteoarthritis conditions
    Johanne Martel-Pelletier
    Osteoarthritis Research Unit, University of Montreal Hospital Centre, Montreal, Canada
    Best Pract Res Clin Rheumatol 22:351-84. 2008
    ..act on the chondrocytes and can lead to repair, remodeling or catabolic processes like those that occur in osteoarthritis. Osteoarthritis is characterized by degradation and loss of articular cartilage, subchondral bone remodeling, ..
  33. ncbi Basic science of articular cartilage and osteoarthritis
    Andrew D Pearle
    Shoulder and Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    Clin Sports Med 24:1-12. 2005
    ..b>Osteoarthritis (OA) is increasingly understood as a family of disorders in which the biomechanical properties of cartilage ..
  34. ncbi Cartilage biology in osteoarthritis--lessons from developmental biology
    Andrew A Pitsillides
    Department of Veterinary Basic Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Nat Rev Rheumatol 7:654-63. 2011
    The cellular and molecular mechanisms responsible for the initiation and progression of osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely understood...
  35. ncbi Osteoarthritis year 2012 in review: biomarkers
    A Mobasheri
    Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington Campus, Sutton Bonington, UK
    Osteoarthritis Cartilage 20:1451-64. 2012
    Biomarkers provide useful diagnostic information by detecting cartilage degradation in osteoarthritis (OA), reflecting disease-relevant biological activity and predicting the course of disease progression...
  36. pmc Age-related changes in the musculoskeletal system and the development of osteoarthritis
    Richard F Loeser
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Geriatr Med 26:371-86. 2010
    b>Osteoarthritis (OA) is the most common cause of chronic disability in older adults...
  37. ncbi Osteoarthritis: an update with relevance for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet 377:2115-26. 2011
    b>Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of osteoarthritis is rising because of the ageing population and the epidemic of obesity...
  38. ncbi Symptomatic hand osteoarthritis in the United States: prevalence and functional impairment estimates from the third U.S. National Health and Nutrition Examination Survey, 1991-1994
    Charles F Dillon
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    Am J Phys Med Rehabil 86:12-21. 2007
    To estimate the United States prevalence of symptomatic hand osteoarthritis using American College of Rheumatology (ACR) physical examination criteria.
  39. ncbi Pathogenesis and management of pain in osteoarthritis
    Paul A Dieppe
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Lancet 365:965-73. 2005
    The term osteoarthritis describes a common, age-related, heterogeneous group of disorders characterised pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of osteophyte ..
  40. ncbi A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
    Velandai K Srikanth
    The Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7001, Australia
    Osteoarthritis Cartilage 13:769-81. 2005
    To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity.
  41. pmc Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
    Richard F Loeser
    Molecular Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Arthritis Rheum 64:705-17. 2012
    To better understand the contribution of age to the development of osteoarthritis (OA).
  42. ncbi Osteoarthritis, inflammation and obesity
    Francis Berenbaum
    University Pierre and Marie Curie, Paris VI, Sorbonne Universités, Paris, France
    Curr Opin Rheumatol 25:114-8. 2013
    Obesity is one of the main risk factors of the incidence and prevalence of knee osteoarthritis. Recent epidemiological data showing an increased risk of hand osteoarthritis in obese patients opened the door to a role of systemic ..
  43. pmc A variant in MCF2L is associated with osteoarthritis
    Aaron G Day-Williams
    Wellcome Trust Sanger Institute, Hinxton, UK
    Am J Hum Genet 89:446-50. 2011
    b>Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact...
  44. ncbi Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
    Paul I Mapp
    Arthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Nat Rev Rheumatol 8:390-8. 2012
    During osteoarthritis (OA), angiogenesis is increased in the synovium, osteophytes and menisci and leads to ossification in osteophytes and the deep layers of articular cartilage...
  45. ncbi Epidemiology of osteoarthritis and associated comorbidities
    Pradeep Suri
    Division of PM and R, VA Boston Healthcare System JP Campus, 150 S Huntington Ave, Boston, MA 02130, USA
    PM R 4:S10-9. 2012
    b>Osteoarthritis (OA) is the most common cause of walking-related disability among older adults in the United States, and the prevalence and incidence of OA are increasing rapidly...
  46. pmc Biomechanical factors in osteoarthritis
    Farshid Guilak
    Departments of Orthopaedic Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Best Pract Res Clin Rheumatol 25:815-23. 2011
    ..An improved understanding of the biophysical and molecular pathways involved in chondrocyte mechanotransduction can provide insight into the development of novel therapeutic approaches for osteoarthritis.
  47. ncbi Osteoarthritis: a problem of growth not decay?
    R M Aspden
    Department of Orthopaedics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Rheumatology (Oxford) 47:1452-60. 2008
    ..New therapies may arise both from recognizing this whole musculoskeletal disease phenotype and by exploring what might be the factors underlying this cellular reversion...
  48. pmc MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    Shigeru Miyaki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Genes Dev 24:1173-85. 2010
    b>Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by insufficient extracellular matrix synthesis and articular cartilage degradation, mediated by several proteinases, including Adamts-5...
  49. ncbi What makes osteoarthritis painful? The evidence for local and central pain processing
    Nidhi Sofat
    Department of Biomedical Sciences, St George s University of London, London, UK
    Rheumatology (Oxford) 50:2157-65. 2011
    ..In this review, we will discuss current concepts underlying the pathophysiology of pain perception in OA and suggest possible directions for the future management of pain in this condition based on recent clinical studies...
  50. ncbi Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
    P M van der Kraan
    Department of Rheumatology, Radboud University, Medical Centre, Geert Grooteplein 28, 6525 Nijmegen, The Netherlands
    Osteoarthritis Cartilage 20:223-32. 2012
    To review the literature on the role and regulation of chondrocyte terminal differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a conceptual model of primary OA development.
  51. pmc Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
    Matthew P Vincenti
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Arthritis Res 4:157-64. 2002
    ..degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor ..
  52. ncbi Role of chondrocyte death and hypocellularity in ageing human articular cartilage and the pathogenesis of osteoarthritis
    A Mobasheri
    Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, Brownlow Hill and Crown Street, Liverpool, L69 7ZJ UK
    Med Hypotheses 58:193-7. 2002
    Apoptotic death of articular chondrocytes has been implicated in the pathogenesis of human osteoarthritis. Although nitric oxide and Fas ligand have been shown to be inducers of chondrocyte apoptosis in vitro and in vivo, the contribution ..
  53. pmc Aging processes and the development of osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 25:108-13. 2013
    Aging is a primary risk factor for the development of osteoarthritis and the understanding of how aging processes contribute to the development of osteoarthritis is an important area of active research...
  54. pmc Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
    V B Kraus
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 19:515-42. 2011
    b>Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA ..
  55. pmc Epidemiology of osteoarthritis
    Yuqing Zhang
    Boston University School of Medicine, MA 02118, USA
    Clin Geriatr Med 26:355-69. 2010
    b>Osteoarthritis (OA) is the most common joint disorder in the United States. Symptomatic knee OA occurs in 10% men and 13% in women aged 60 years or older...
  56. pmc Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up
    Margreth Grotle
    National Resource Centre for Rehabilitation in Rheumatology, Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, POBox 23 Vinderen, 0319 Oslo, Norway
    BMC Musculoskelet Disord 9:132. 2008
    Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation...
  57. ncbi Measures of molecular composition and structure in osteoarthritis
    Deborah Burstein
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    Radiol Clin North Am 47:675-86. 2009
    b>Osteoarthritis involves ongoing degradative and healing processes that occur at the molecular level in multiple tissues in the joint in response to a number of biochemical and mechanical factors...
  58. ncbi Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand
    Evangelos Evangelou
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 60:1710-21. 2009
    GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of the GDF5 gene or the rs7775 ..
  59. ncbi Assessment of gastrointestinal and cardiovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study
    Angel Lanas
    Universidad de Zaragoza, Servicio de Aparato Digestivo, Hospital Clinico, CIBERehd, I CS, Zaragoza, Spain
    Ann Rheum Dis 69:1453-8. 2010
    Medical management of adults with osteoarthritis (OA) who require non-steroidal anti-inflammatory drugs (NSAIDs) must be decided after assessing prevalent gastrointestinal (GI) and cardiovascular (CV) risks in the individual patient.
  60. ncbi Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
    Francis K L Chan
    Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Lancet 376:173-9. 2010
    ..We aimed to compare risk of gastrointestinal events associated with celecoxib versus diclofenac slow release plus omeprazole...
  61. ncbi The role of reactive oxygen species in homeostasis and degradation of cartilage
    Y E Henrotin
    Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart Tilman, Liege, Belgium
    Osteoarthritis Cartilage 11:747-55. 2003
    ..ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable.
  62. ncbi Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    Siyoung Yang
    Cell Dynamics Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    Nat Med 16:687-93. 2010
    ..Our results collectively demonstrate that HIF-2alpha causes cartilage destruction by regulating crucial catabolic genes...
  63. ncbi Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study
    Yuqing Zhang
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Epidemiol 156:1021-7. 2002
    b>Osteoarthritis is one of the most common joint disorders in the elderly, yet few studies have targeted symptomatic osteoarthritis, especially symptomatic hand osteoarthritis...
  64. ncbi Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis
    Sezgin Sarban
    Department of Orthopaedic Surgery, Harran University, Medical Faculty, 63200 Sanliurfa, Turkey
    Clin Biochem 38:981-6. 2005
    ..The aim of the present study was to investigate the total antioxidant capacity (TAC), levels of lipid peroxidation (LPO), and antioxidant enzyme activities in patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
  65. ncbi Atlas of individual radiographic features in osteoarthritis, revised
    R D Altman
    The David Geffen School of Medicine, The University of California at Los Angeles, Los Angeles, CA 91390, USA
    Osteoarthritis Cartilage 15:A1-56. 2007
    Develop a radiographic atlas of osteoarthritis (OA) to be used as a template and guide for grading radiographs of osteoarthritic lesions of the hand, hip and knee.
  66. ncbi NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    J A Roman-Blas
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA19107 5541, USA
    Osteoarthritis Cartilage 14:839-48. 2006
    ..of the NF-kappaB signaling pathways to the pathogenesis of various rheumatic diseases, in particular, of osteoarthritis (OA) and rheumatoid arthritis (RA)...
  67. ncbi Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data
    Harry Kotlarz
    De Puy, Inc, Warsaw, Indiana, USA
    Arthritis Rheum 60:3546-53. 2009
    b>Osteoarthritis (OA) is a major debilitating disease affecting approximately 27 million persons in the US. Yet, the financial costs to patients and insurers remain poorly understood...
  68. pmc Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
    Koichi Murata
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Arthritis Res Ther 12:R86. 2010
    ..In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA).
  69. pmc Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
    Mary B Goldring
    Tissue Engineering, Regeneration, and Repair Program, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA
    Eur Cell Mater 21:202-20. 2011
    ..similarities and particularly the marked differences in mechanisms of cartilage remodeling during development, osteoarthritis, and aging may lead to more effective strategies for preventing cartilage damage and promoting repair...
  70. pmc CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis
    Rachel E Miller
    Department of Internal Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 109:20602-7. 2012
    b>Osteoarthritis is one of the leading causes of chronic pain, but almost nothing is known about the mechanisms and molecules that mediate osteoarthritis-associated joint pain...
  71. ncbi Mesenchymal stem cells in osteoarthritis
    Frank P Luyten
    Department of Rheumatology, University Hospitals KULeuven, Leuven, Belgium
    Curr Opin Rheumatol 16:599-603. 2004
    ....
  72. pmc Epidemiology and burden of osteoarthritis
    Anna Litwic
    MRC Lifecourse Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, UK
    Br Med Bull 105:185-99. 2013
    b>Osteoarthritis (OA) is a degenerative joint disease involving the cartilage and many of its surrounding tissues. Disease progression is usually slow but can ultimately lead to joint failure with pain and disability...
  73. pmc Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention
    Donald D Anderson
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, Iowa 52242, USA
    J Orthop Res 29:802-9. 2011
    ..40% of people who suffer significant ligament or meniscus tears, or articular surface injuries, will develop osteoarthritis (OA). Correspondingly, 12% or more of all patients with lower extremity OA have a history of joint injury...
  74. ncbi Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    Louise N Reynard
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Hum Mol Genet 20:3450-60. 2011
    ..polymorphism (SNP) located in the 5'UTR of GDF5 is associated, at the genome-wide significance level, with osteoarthritis susceptibility, and with other musculoskeletal phenotypes including height, congenital hip dysplasia and ..
  75. ncbi Large-scale extraction and characterization of CD271+ multipotential stromal cells from trabecular bone in health and osteoarthritis: implications for bone regeneration strategies based on uncultured or minimally cultured multipotential stromal cells
    E Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 62:1944-54. 2010
    To test the hypothesis that CD45(low)CD271+ bone marrow multipotential stromal cells (MSCs) are abundant in the trabecular bone niche and to explore their functional "fitness" in health and osteoarthritis (OA).
  76. ncbi The economic burden of osteoarthritis
    Ryan Bitton
    Health Plan of Nevada, Inc, Las Vegas, NV 88011, USA
    Am J Manag Care 15:S230-5. 2009
    As the most common form of joint disease, osteoarthritis (OA) is associated with an extremely high economic burden. This burden is largely attributable to the effects of disability, comorbid disease, and the expense of treatment...
  77. ncbi Clinical comorbidity in osteoarthritis: associations with physical function in older patients in family practice
    Umesh T Kadam
    Primary Care Sciences Research Centre, Keele University, Staffordshire, England
    J Rheumatol 34:1899-904. 2007
    To determine the influence of comorbidity on physical function in osteoarthritis (OA) consulters aged 50 years and over in family practice.
  78. pmc Care and management of osteoarthritis in adults: summary of NICE guidance
    Philip G Conaghan
    Section of Musculoskeletal Disease, University of Leeds, Leeds LS7 4SA
    BMJ 336:502-3. 2008
  79. ncbi Aging theories of primary osteoarthritis: from epidemiology to molecular biology
    T Aigner
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Germany
    Rejuvenation Res 7:134-45. 2004
    b>Osteoarthritis is the most common disabling condition of humans in the western world...
  80. ncbi Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis
    T E McAlindon
    The Arthritis Center, Boston University School of Medicine, Mass 02118, USA
    JAMA 283:1469-75. 2000
    Glucosamine and chondroitin preparations are widely touted in the lay press as remedies for osteoarthritis (OA), but uncertainty about their efficacy exists among the medical community.
  81. ncbi Etiopathogenesis of osteoarthritis
    Kenneth D Brandt
    Kansas University Medical Center, 5755 Windsor Drive, Fairway, Kansas City, KS 66205, USA
    Rheum Dis Clin North Am 34:531-59. 2008
    In this article, the authors posit that, because osteoarthritis (OA) involves all of the tissues of the synovial joint, the emphasis on the loss of cartilage, in particular, is misguided...
  82. ncbi Expression of bone resorption genes in osteoarthritis and in osteoporosis
    Darja Bitenc Logar
    Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000, Ljubljana, Slovenia
    J Bone Miner Metab 25:219-25. 2007
    ..cathepsin K, MMP-9, TRAP, RANKL, OPG, and osteocalcin gene expression in the proximal femur of patients with osteoarthritis with that of patients with femoral neck fracture...
  83. ncbi An update on the pathogenesis and epidemiology of osteoarthritis
    David T Felson
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA
    Radiol Clin North Am 42:1-9, v. 2004
    b>Osteoarthritis is a disease affecting all joint structures, not just hyaline articular cartilage. It develops as a consequence of injurious activities acting on a vulnerable joint...
  84. ncbi Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:3684-92. 2008
    ..Toll-like receptors (TLRs) 1-10 in synovial and skin fibroblasts and to determine the expression levels of TLRs 2, 3, and 4 in synovial tissues from patients with early rheumatoid arthritis (RA), longstanding RA, and osteoarthritis (OA).
  85. ncbi Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis
    Mehdi Shakibaei
    Institute of Anatomy, Ludwig Maximilians University Munich, Pettenkoferstrasse 11, D 80336 Munich, Germany
    Biochem Pharmacol 73:1434-45. 2007
    ..IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) play a key role in the pathogenesis of osteoarthritis (OA)...
  86. ncbi Topical therapies for osteoarthritis
    Roy D Altman
    David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, 90024, USA
    Drugs 71:1259-79. 2011
    ..analgesic efficacy, safety and tolerability of topical NSAIDs, salicylates and capsaicin for the management of osteoarthritis (OA) pain...
  87. ncbi Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis
    Anne Christine Bay-Jensen
    Cartilage Biology and Biomarkers R and D, Nordic Bioscience, Herlev, Denmark
    Clin Biochem 44:423-9. 2011
    ..In joint degenerative diseases, the collagens are degraded by matrix metalloproteinases and protein fragments are released to serum as potential biomarkers...
  88. ncbi Peroxisome proliferator-activated receptor gamma in osteoarthritis
    Hassan Fahmi
    Osteoarthritis Research Unit, Notre Dame Hospital, University of Montreal Hospital Research Centre CRCHUM, 1560 Sherbrooke East, Pavillon J A DeSève, Y 2628, Montreal, QC, H2L 4M1, Canada
    Mod Rheumatol 21:1-9. 2011
    b>Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries...
  89. ncbi A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility
    Kay Chapman
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    Hum Mol Genet 17:1497-504. 2008
    ..between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 (+104T/C; rs143383) and osteoarthritis (OA) in European and Asian populations...
  90. ncbi Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES III data
    Rajitkanok Amy Puenpatom
    Health Outcomes and Pharmacoeconomics, Endo Pharmaceuticals Inc, Chadds Ford, PA 19317, USA
    Postgrad Med 121:9-20. 2009
    b>Osteoarthritis (OA) and cardiovascular disease (CVD) share age and obesity as risk factors, but may also be linked by pathogenic mechanisms involving metabolic abnormalities and systemic inflammation...
  91. ncbi Psychometric testing of the Helsinki chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis
    Anna K Hielm-Björkman
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, FIN 00014, Finland
    Am J Vet Res 70:727-34. 2009
    To determine the validity, reliability, and sensitivity of a published chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis.
  92. ncbi Early management of osteoarthritis
    Roy Davis Altman
    Am J Manag Care 16:S41-7. 2010
    b>Osteoarthritis (OA) is highly prevalent and increasing in frequency; the number of patients with OA has increased by nearly 30% over the past 10 years. The primary symptom of OA is pain...
  93. pmc The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis
    Eric C Sayre
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    PLoS ONE 5:e10470. 2010
    b>Osteoarthritis (OA) has a significant impact on individuals' ability to work. Our goal was to investigate the effects of the site of OA (knee, hip, hand, foot, lower back or neck) on employment reduction due to OA (EROA).
  94. pmc Use of an activity monitor to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 237:66-70. 2010
    To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo.
  95. pmc Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis
    Dorothy Cimino Brown
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Vet Med Assoc 233:1278-83. 2008
    To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo.
  96. ncbi Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome
    James D Katz
    Department of Medicine, The George Washington University, Washington, District of Columbia, USA
    Curr Opin Rheumatol 22:512-9. 2010
    Labeling osteoarthritis as a degenerative arthritis is a misnomer. It is now clear that an active genetic and proteomic profile suggests inflammation...
  97. ncbi A New Zealand national joint registry review of 202 total ankle replacements followed for up to 6 years
    Anton H Hosman
    Department of Orthopedic Surgery and Musculoskeletal Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
    Acta Orthop 78:584-91. 2007
    ..The aim of this study was to document and evaluate the early results of a nationwide series of total ankle replacements (TARs) performed using second- and third-generation implants...
  98. ncbi Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
    Tadashi Hayami
    Department Molecular Endocrinology and Bone Biology, Merck Res Labs, West Point, PA 19486, USA
    Bone 38:234-43. 2006
    b>Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction, subchondral bone sclerosis, and osteophyte formation...
  99. pmc Analysing the role of endogenous matrix molecules in the development of osteoarthritis
    Nidhi Sofat
    St George s, University of London, UK
    Int J Exp Pathol 90:463-79. 2009
    b>Osteoarthritis (OA) is the most common form of arthritis worldwide. In this condition, damage to the extracellular matrix (ECM) of cartilage occurs, resulting in joint destruction...
  100. ncbi Angiogenesis in osteoarthritis
    Sadaf Ashraf
    Academic Rheumatology, University of Nottingham, Nottingham, UK
    Curr Opin Rheumatol 20:573-80. 2008
    Much has been documented in recent years on the possible involvement of angiogenesis in osteoarthritis. An understanding of the various regulatory mechanisms controlling blood vessel growth in the joint should lead to novel therapeutics, ..
  101. pmc Why is osteoarthritis an age-related disease?
    A Shane Anderson
    Section of Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Best Pract Res Clin Rheumatol 24:15-26. 2010
    Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable consequence of growing old...

Research Grants78

  1. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..Our preliminary data indicate that compared to rheumatoid arthritis (RA) and osteoarthritis (OA), the synovium of PsA is rich in NGF;major source of NGF is FLS;TrkA is upregulated in FLS, endothelial ..
  2. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is associated with muscle strength decline, cartilage breakdown and pain-related disability...
  3. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..While most AR cases are classified as osteoarthritis (OA), affecting over 27 million Americans, other forms of the disease are also prevalent, including rheumatoid ..
  4. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..has been shown to improve bone metabolism in healthy women, and to be beneficial for people with fibromyalgia, osteoarthritis and rheumatoid arthritis;however, no randomized trial has examined the impact of exercise on arthralgia or ..
  5. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    b>Osteoarthritis is a painful and debilitating disease of the synovial joints, affecting an estimated 21 million people in the United States...
  6. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..These areas include: 1) biology and clinical implications of osteoarthritis (pathogenesis, biomechanical considerations, rheumatologic and orthopedic issues in diagnosis and treatment);2)..
  7. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ELIZABETH ALICE ERICKSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Advanced age is the single greatest risk factor for developing osteoarthritis (OA)...
  8. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The long-term goal of this study is to understand the pathogenesis of osteoarthritis (OA)-like changes in articular cartilage that are associated with osteochondrodysplasias caused by mutations in ..
  9. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..Moreover, an increased incidence of ankle OA has been suggested. Osteoarthritis often limits overall mobility and may not only restrict a patient's activities of daly life, but also ..
  10. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..While rheumatoid arthritis (RA) and osteoarthritis (OA) are largely age and use related, osteoarthritis can result from injury at any age and produce chronic ..
  11. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common musculoskeletal disease among the aging population in the United States and throughout the world...
  12. Acupuncture for Aromatase Inhibitor-Related Arthralgias in Breast Cancer Patients
    Dawn Hershman; Fiscal Year: 2013
    ..and functional status via self administered questionnaires (Western Ontario and McMaster Universities Osteoarthritis (WOMAC), Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-..
  13. Identification of the transcriptional regulators of chondrocyte hypertrophy
    ANDREW BRUCE LASSAR; Fiscal Year: 2013
    ..of reagents that could block this program in articular cartilage and thereby slow the progression of osteoarthritis. PUBLIC HEALTH RELEVANCE: The course of cartilage degradation in osteoarthritis (OA) involves an activation of ..
  14. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..effect of supplementation on incidence of other disorders, specifically hypertension, cardiovascular disease, osteoarthritis, colonic adenomas and diabetes, upper respiratory infections and falls...
  15. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    b>Osteoarthritis (OA) is the most common musculoskeletal disease among the aging population in the United States and throughout the world...
  16. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a painful and debilitating disease of the synovial joints, affecting an estimated 27 million people in the United States...
  17. Histone Deacetylation Regulates Growth Plate Development
    Lei Wei; Fiscal Year: 2013
    ..The understanding of cell differentiation in growth plate may also be important to the understanding of abnormal chondrocyte differentiation in osteoarthritis.
  18. The Toll-like receptor pathway in Meniscal Injury and Osteoarthritis
    CARLA ROSE SCANZELLO; Fiscal Year: 2013
    ..She has a particular interest in the role that inflammation plays in osteoarthritis (OA) pathogenesis, which she began to pursue in earnest as a Rheumatology Fellow...
  19. BMP2 signaling of the development of osetoarthritis
    Vicki Rosen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) affects over 200 million people worldwide including 27 million Americans, and it is estimated that the US spends $128 billion dollars each year on OA related health care (1, 2)...
  20. A new experimental model of knee joint trauma
    TAMMY L HAUTDONAHUE; Fiscal Year: 2012
    ..after traumatic rupture there is a significant increase in the risk of a long term, chronic disease called osteoarthritis (OA)...
  21. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..Thus, in addition to this study providing a potential paradigm shift in our thinking regarding the "disease" of OA, this study also develops practical clinical tools for identifying the presence of centrally-enhanced pain in OA. ..
  22. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..Monitoring muscle viscosity could help in anticipating joint diseases, such as tendonitis, bursitis and osteoarthritis and decreasing the probability of osteoporotic bone fracture...
  23. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..meniscus function and subsequent joint health since tears and disruption of the meniscus lead to degenerative osteoarthritis [2]. Meniscal repairs have an incomplete and failed healing rate of 50% [3]...
  24. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2012
    ..knee endures high rates of traumatic injury to its soft tissue structures and it is predominantly affected by osteoarthritis, chronically induced by abnormalities in mechanical loading or how it is transferred to the cartilage...
  25. Cathespin K Radioligands for In Vivo Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..g., osteoarthritis, rheumatoid arthritis, osteoporosis) involving potential bone loss...
  26. The Johnston County OA Project: Arthritis and Disability
    Joanne M Jordan; Fiscal Year: 2013
    ..This proposal requests process and technical support to complete the 3rd follow-up (T3) of the Johnston County Osteoarthritis Project, an average of 4 - 7 years after the 2nd 5-year follow-up (T2), approximately 10 - 15 years after the ..
  27. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is one of the most prevalent diseases that lead to disabilities in older Americans [13]...
  28. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..of customary Fit and Strong!-an evidence-based physical activity/behavior change program for older adults with osteoarthritis (OA)-to an enhanced version of the program that also addresses diet and weight...
  29. Function and Regulation of CD-RAP
    Linda J Sandell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis will affect 50 million Americans by 2020...
  30. A novel therapeutic approach for pressure ulcers
    EDWARD PAUL MONAGHAN; Fiscal Year: 2012
    ..Tissue PEA levels are substantially decreased in patients suffering from rheumatoid arthritis or osteoarthritis. Moreover, pro-inflammatory stimuli suppress PEA production in innate immune cells from rats and mice, ..
  31. Phase-contrast X-ray imaging system for large joints
    Dan Stutman; Fiscal Year: 2012
    ..method for joint soft tissues would aid in the diagnosis and treatment of Rheumatoid Arthritis (RA) and Osteoarthritis (OA), by helping detect their destructive effects well before they are evident in conventional radiography...
  32. Motivational Interviewing and Physical Activity Behavior Change in Arthritis
    Linda Ehrlich-Jones; Fiscal Year: 2012
    ..focuses on increasing lifestyle physical activity in persons with rheumatoid arthritis (RA) and knee osteoarthritis (OA)...
  33. An interactive web-based intervention to achieve healthy weight in young children
    Ellen Wald; Fiscal Year: 2013
    ..leads to an increased probability of becoming overweight adults with an increased risk for hypertension, osteoarthritis, type 2 diabetes, and high cholesterol compared to normal weight children...
  34. The role of the kimble gene in regulating craniofacial morphogenesis
    Daniel S Levic; Fiscal Year: 2013
    ..by applicant): Chondrocyte cell death is a central component of many degenerative cartilage diseases, such as osteoarthritis and temporomandibular joint disorders, and thus has a substantial public health impact...
  35. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    b>Osteoarthritis (OA) is a leading cause of disability. New clinical strategies to improve evaluation, repair, and regeneration of damaged articular cartilage are needed to prevent or delay the onset of disabling pain and OA...
  36. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
    ..We have observed acquired alterations of lubricin in patients with common joint diseases, including osteoarthritis, rheumatoid arthritis, and traumatic joint injury...
  37. Defining Common Molecular Parameters For Onset and Progression of Osteoarthritis
    Roland Wolkowicz; Fiscal Year: 2010
    ..strategy to achieve a major "leap forward" in defining common biomolecular mechanisms underpinning osteoarthritis (OA)...
  38. Collider Bias and the Risk Factor Paradoxes in Rheumatic Disease Research
    UYEN SA DUC TRAN NGUYEN; Fiscal Year: 2013
    ..Rheumatic conditions and their sequelae, including rheumatoid arthritis (RA), psoriatic arthritis, and knee osteoarthritis (OA), constitute a tremendous disease burden in the US and worldwide...
  39. Novel Early Intervention to Prevent Post-Traumatic Osteoarthritis
    Dominik R Haudenschild; Fiscal Year: 2013
    ..Physicians acknowledge that even such relatively minor joint traumas ultimately progress to osteoarthritis in a majority of patients...
  40. Role of Transcription Factor ERG in Skeletogenesis
    Maurizio Pacifici; Fiscal Year: 2013
    ..Erg-deficient mice to knee's medial collateral ligament (MCL) transection to induce experimental osteoarthritis (OA)...
  41. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is a major cause of disability among Veterans and is the primary indication of knee replacement in the VA...
  42. 2012 AAOS Femoroacetabular Impingement Research Symposium
    John C Clohisy; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) affects an estimated 30% of Americans over 60 years of age and is one of the leading causes of reduced quality of life and loss of function for orthopaedic patients...
  43. Studies of Chondroyte Maturation
    Cristina C Teixeira; Fiscal Year: 2010
    ..anomalies, and other debilitating cartilage pathology such as degenerative temporomandibular joint disease and osteoarthritis. The focus of this proposal is to determine the role of nitric oxide (NO) in growth plate cartilage...
  44. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
    ..can thus cause growth retardation, compression of nerves and tendons, skeletal deformities and early onset osteoarthritis, and become malignant in about 5% of patients...
  45. Transdermal delivery of 2-Arachidonoyl glycerol (2-AG) for the treatment of arthr
    Audra L Stinchcomb; Fiscal Year: 2012
    ..proposes to improve the transdermal delivery of 2-arachidonoylglycerol (2-AG) for the adjunct treatment of osteoarthritis, rheumatoid arthritis (RA) and joint pain secondary to other autoimmune diseases, such as inflammatory bowel ..
  46. Acceptance-based Group Intervention for Binge Eating
    Niloofar Afari; Fiscal Year: 2012
    ..related to a number of physical and mental health co-morbidities such as diabetes, coronary heart disease, osteoarthritis, respiratory symptoms, depression, and anxiety...
  47. Transcriptional Regulation of Indian Hedgehog Expression in Chondrocytes
    Xiangli Yang; Fiscal Year: 2012
    ..degeneration as well as during bone regeneration, this study is directly applicable to diseases such as osteoarthritis and fractures...
  48. Common mechanisms of Osteoarthritis in three mouse models
    Robert E Seegmiller; Fiscal Year: 2010
    Degeneration of synovial joint cartilage in the form of osteoarthritis (OA) is one of the leading causes of chronic disability, yet the molecular pathogenesis of OA is poorly understood...
  49. Sex Differences in Musculoskeletal Conditions across the Lifespan
    Nancy E Lane; Fiscal Year: 2013
    ..States, and the increases in incidence of musculoskeletal diseases with aging (particularly osteoporosis and osteoarthritis) is higher in women than in men, and leads to a significant amount of disability and reduced quality of life...
  50. Musculoskeletal Biomechanics of Gradient Walking in Obese Adults
    RAYMOND CLIFTON BROWNING; Fiscal Year: 2012
    ..g. knee) osteoarthritis (OA). Thus, prescribing brisk walking as exercise for treating obesity may be biomechanically unsound...
  51. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    Robert L Mauck; Fiscal Year: 2012
    ..Due to limitations in cartilage's natural healing capacity, and given the increasing incidence of osteoarthritis, there exists a growing demand for cell-based strategies for repair...
  52. Biological Markers of System Burden in Symptomatic Knee OA: A Prospective Study
    KIMBERLY THERESA SIBILLE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a leading cause of pain and functional limitation in the United States. There are significant individual and ethnic group differences in the experience of OA...
  53. Using CERs to Optimize Quality of Life for Persons with Diabetes and Chronic Pain
    Monika M Safford; Fiscal Year: 2010
    ..We target a very common clinical problem in need of quality improvement: patients with chronic pain, osteoarthritis (OA) and diabetes (DM)...
  54. Therapeutic Role for P21 in Suppressing IL-1 Beta Mediated Pathologies
    HARRIS R PERLMAN; Fiscal Year: 2013
    ..dependent kinase (CDK) inhibitor p21(WAF1/CIP1) is reduced in synovial tissue from RA patients compared to osteoarthritis patients...
  55. Sex-specific movement differences in young adults with and without hip pain
    CARA L LEWIS; Fiscal Year: 2013
    ..of hip pain in young adults, especially females, and have been linked to the premature development of hip osteoarthritis (OA). Recently, femoroacetabular impingement (FAI) has been implicated as a cause of labral injury and OA...
  56. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
    ..Articular cartilage destruction is a central factor in the pathogenesis of joint diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA)...
  57. Sex Hormones and Rat Anterior Cruciate Ligament Strength
    William A Romani; Fiscal Year: 2010
    ..These expenses do not include the long-term costs related to the premature osteoarthritis (OA) that often follows the initial trauma...
  58. Development of a Low Cost, Real-time Biofeedback Gait Retraining System
    SAUNDERS WHITTLESEY; Fiscal Year: 2012
    ..and perhaps more importantly, for correcting gait patterns associated with the risk of impairments such as osteoarthritis. The potential of such systems is virtually limitless because they are non- invasive and can be based on a ..
  59. Patient-Specific Modeling of Total Knee Arthroplasty
    ROBERT ANTHONY SISTON; Fiscal Year: 2012
    ..TKA is a common surgical procedure used to treat degenerative joint diseases such as osteoarthritis. An estimated 500,000 TKAs were performed in the United States in 2006, and approximately 3...
  60. In Vivo Gene Therapy for Treatment of Osteoarthritis
    Jeffrey B Mason; Fiscal Year: 2012
    Aberrant bone formation, a primary factor in osteoarthritis (OA) joint pathology, is a key issue when proposing treatments for the clinical symptoms associated with OA...
  61. IMMUNOBIOLOGY OF AGING
    CHARLES GARRISON FATHMAN; Fiscal Year: 2010
    ..inflammatory diseases (COPD or rheumatoid arthritis) and degenerative diseases such as atherosclerosis and osteoarthritis. Yet, systematic efforts to understand the role of aging on immunological mechanisms are lacking...
  62. Collagen Diversity and Pathobiology in Skeletal Tissues
    David R Eyre; Fiscal Year: 2013
    ..cause cartilages and other collagenous tissues of low turnover to degenerate in the adult musculoskeleton in osteoarthritis, disc degeneration and related disorders of collagen framework failure...
  63. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    b>Osteoarthritis is an insidious disease that results in a heavy toll of human suffering, debilitation, and economic loss...
  64. OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN
    Michael Nevitt; Fiscal Year: 1992
    b>Osteoarthritis (OA) is the leading cause of activity limitation in older women. Yet, there is little data about risk factors for and consequences of the disease in older women...
  65. Fibrillin 2 and Developmental Genetics of Hip Dysplasia in a Canine Model
    Rory Todhunter; Fiscal Year: 2009
    ..of the hip, DDH) is hip joint laxity which results in hip instability, subluxation, and debilitating secondary osteoarthritis. We genotyped a cross breed pedigree of 159 resistant greyhounds and dysplastic Labrador retrievers and we ..
  66. Clinical Evaluation of GI Safer Naproxen for the Treatment of Osteoarthritis
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..The current standard of care for osteoarthritis (OA) and other chronic disorders of pain and inflammation requires consideration of not only gastrointestinal (..
  67. GI-Safer Naproxen Formulation R&D for the Treatment of Osteoarthritis and Related
    Upendra Marathi; Fiscal Year: 2009
    ..b>Osteoarthritis (OA), the clinical syndrome of joint pain and dysfunction caused by joint degeneration, affects more people ..
  68. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    b>Osteoarthritis is one of the most common diseases suffered by elderly persons in Western countries. This disabling joint disorder is usually multifactorial in nature and thus of unknown origin in individual cases...
  69. DOXYCYCLINE EFFECT ON OSTEOARTHRITIS PROGRESSION
    Kenneth Brandt; Fiscal Year: 2003
    DESCRIPTION (from the application): Osteoarthritis (OA) of the knee is the most common cause of chronic disability in this country and has enormous socio-economic impact. Notably, management of OA today is limited to symptomatic therapy...
  70. The In Vivo Biomechanics of Lateral Ankle Ligament Injury and Reconstruction
    Louis E DeFrate; Fiscal Year: 2010
    ..have reported that between 10 to 40% of patients experience chronic symptoms including instability, pain, and osteoarthritis. Abnormal kinematics have been thought to contribute to the development of osteoarthritis, but the precise ..
  71. The Effect of Exercise on Progression of Knee OA
    ANDREW CONCOFF; Fiscal Year: 2003
    ..skills to design and conduct clinical investigations regarding the interrelationship between exercise and osteoarthritis (OA), this application proposes that a physician with formal Rheumatology and Sports Medicine fellowship ..
  72. METALLOPROTEINASES IN AGING AND OSTEOARTHRITIS
    Virginia Kraus; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Osteoarthritis (OA) is a degenerative process in joints characterized by functional deterioration, abrasion of articular cartilage and formation of new bone at and around joint surfaces...
  73. A Pharmacokinetic Study of glucosamine and chondroitin
    Christopher Jackson; Fiscal Year: 2005
    b>Osteoarthritis is the most common musculoskeletal disease in the United States and throughout the world...
  74. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Symptomatic knee osteoarthritis affects 6% of the U.S. adult population and 12-13% of those age 60 and over (Felson and Zhang, 1998)...
  75. Biomarkers of the risk for post-traumatic osteoarthritis
    James A Martin; Fiscal Year: 2010
    ..Our proposal entitled "Biomarkers of the Risk for Post-Traumatic Osteoarthritis" addresses an urgent need to identify molecular markers related to the processes that drive post-traumatic ..
  76. Aerobic Exercise Intervention for Knee Osteoarthritis
    Kenton Kaufman; Fiscal Year: 2005
    ..Individuals with osteoarthritis restrict joint motion and limit activity in order to decrease their symptoms...
  77. Biomarker response to acute joint injury in an animal model of osteoarthritis
    TROY NEAL TRUMBLE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute joint injury often results in the development of osteoarthritis. Because osteoarthritis affects 1 in 3 individuals in the United States, there is an urgent need to delineate the biomarker ..
  78. Pain Assessment in Elders with Osteoarthritis
    Pao Feng Tsai; Fiscal Year: 2004
    Knee and hip osteoarthritis (OA) are highly prevalent (16.6%-33% for the knee and 10.4%-26.3% for the hip) and the leading causes of disability in elders. Activity instigates and aggravates pain in patients with severe knee or hip OA...