gouty arthritis

Summary

Summary: Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.

Top Publications

  1. ncbi Gout: a review of its aetiology and treatment
    E K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 10:261-70. 2004
  2. ncbi Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis
    Gregory C Borstad
    Department of Rheumatology, Wilford Hall US Air Force Medical Center, Lackland AFB, San Antonio, Texas, USA
    J Rheumatol 31:2429-32. 2004
  3. ncbi Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis
    Carle Ryckman
    Infectious Diseases Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Sainte Foy, Quebec G1V 4G2, Canada
    Arthritis Rheum 48:2310-20. 2003
  4. ncbi Gouty arthritis in acute cerebrovascular disease
    Ya Hui Lin
    Department of Neurology, Chiayi Branch, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    Cerebrovasc Dis 28:391-6. 2009
  5. ncbi Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis
    A Norrie Pearce
    TerraMarine Pharmaceuticals, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Nat Prod 70:936-40. 2007
  6. ncbi Effect of acute gouty arthritis on sleep patterns: a preclinical study
    Uriah Guevara-López
    Department of Pain and Palliative Medicine, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico
    Eur J Pain 13:146-53. 2009
  7. ncbi Concomitant septic and gouty arthritis--an analysis of 30 cases
    K H Yu
    Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan, Republic of China
    Rheumatology (Oxford) 42:1062-6. 2003
  8. ncbi Does prolonged systemic glucocorticoid use increase risk of tophus formation among gouty arthritis patients?
    Anne Annette P Raso
    University of Santo Tomas Hospital, Manila, Philippines
    Int J Rheum Dis 12:243-9. 2009
  9. ncbi Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study
    Mahaboobkhan Rasool
    Faculty of Biosciences, School of Bioengineering and Biosciences, Vellore Institute of Technology Deemed University, Vellore 632014, Tamil Nadu, India
    Chem Biol Interact 164:174-80. 2006
  10. ncbi Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages
    Ming Shium Hsieh
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 89:791-9. 2003

Research Grants

  1. A Regulatory Checkpoint in the Pathogenesis of Inflammatory Arthritis
    Christian Stehlik; Fiscal Year: 2013
  2. Impact of Unapproved Drug Initiative on Colchicine Use
    Eswar Krishnan; Fiscal Year: 2013
  3. Preclinical Development of Uricase-PEG 20
    JOHN BOMALASKI; Fiscal Year: 2002
  4. MUTATIONAL ANALYSIS OF A PARASITE PURINE SALVAGE ENZYME
    SYDNEY CRAIG; Fiscal Year: 2001
  5. UNDERSTANDING THE DESIGN OF MOLECULAR MOTORS
    John Murray; Fiscal Year: 2000
  6. IDIOTYPES OF RHEUMATOID FACTORS
    George Moxley; Fiscal Year: 1990
  7. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
  8. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
  9. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
  10. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005

Detail Information

Publications201 found, 100 shown here

  1. ncbi Gout: a review of its aetiology and treatment
    E K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 10:261-70. 2004
    ..To review the current understanding of the causes and the management of gout...
  2. ncbi Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis
    Gregory C Borstad
    Department of Rheumatology, Wilford Hall US Air Force Medical Center, Lackland AFB, San Antonio, Texas, USA
    J Rheumatol 31:2429-32. 2004
    ..We investigated if colchicine administration during initiation of allopurinol for chronic gouty arthritis reduces the frequency and/or severity of acute gout flares.
  3. ncbi Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis
    Carle Ryckman
    Infectious Diseases Research Center, Centre de Recherche du Centre Hospitalier de l Universite Laval, 2705 Laurier Boulevard, Sainte Foy, Quebec G1V 4G2, Canada
    Arthritis Rheum 48:2310-20. 2003
    ..To examine the role of chemokines, S100A8, and S100A9 in neutrophil accumulation induced by the causative agent of gout, monosodium urate monohydrate (MSU) crystals...
  4. ncbi Gouty arthritis in acute cerebrovascular disease
    Ya Hui Lin
    Department of Neurology, Chiayi Branch, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    Cerebrovasc Dis 28:391-6. 2009
    b>Gouty arthritis is a metabolic disorder associated with several medical diseases and is considered as a high-risk factor of acute myocardial infarction and cardiovascular mortality...
  5. ncbi Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis
    A Norrie Pearce
    TerraMarine Pharmaceuticals, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Nat Prod 70:936-40. 2007
    ..6 micromol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid...
  6. ncbi Effect of acute gouty arthritis on sleep patterns: a preclinical study
    Uriah Guevara-López
    Department of Pain and Palliative Medicine, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico
    Eur J Pain 13:146-53. 2009
    ..Although some evidences suggest that sleep and pain may interact in a complex way, polysomnographic studies in animals with acute nociception are limited in number...
  7. ncbi Concomitant septic and gouty arthritis--an analysis of 30 cases
    K H Yu
    Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan, Republic of China
    Rheumatology (Oxford) 42:1062-6. 2003
    ..To analyse the clinical features and outcomes of gouty patients with concomitant septic arthritis in a medical centre...
  8. ncbi Does prolonged systemic glucocorticoid use increase risk of tophus formation among gouty arthritis patients?
    Anne Annette P Raso
    University of Santo Tomas Hospital, Manila, Philippines
    Int J Rheum Dis 12:243-9. 2009
    ..To determine the relationship of steroid use with tophus formation and other comorbid conditions among male gout patients...
  9. ncbi Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study
    Mahaboobkhan Rasool
    Faculty of Biosciences, School of Bioengineering and Biosciences, Vellore Institute of Technology Deemed University, Vellore 632014, Tamil Nadu, India
    Chem Biol Interact 164:174-80. 2006
    ..These results provide evidence for the suppressive effect of W. somnifera root powder by retarding amplification and propagation of the inflammatory response without causing any gastric damage...
  10. ncbi Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages
    Ming Shium Hsieh
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 89:791-9. 2003
    To investigate the relevance of gelatinase-B (matrix metalloproteinase 9, MMP-9) in gouty arthritis (GA), we tested the occurrence of MMP-9 in GA patients and cell culture system...
  11. ncbi The clinical significance of gelatinase B in gouty arthritis of the knee
    Shu Chen Chu
    Department of Food Science, Chungtai Institute of Health Sciences and Technology, Taichung 406, Taiwan
    Clin Chim Acta 339:77-83. 2004
    Clinically, gouty arthritis is associated with severe inflammation, such as pain, swelling and erythema of the joints...
  12. ncbi Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18
    Taku Inokuchi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine 33:21-7. 2006
    ..those of IL-1beta, tumor necrosis factor-alpha, IL-6, and IL-8, are elevated in the plasma of patients with gouty arthritis, the plasma concentrations of those cytokines were measured in 31 males with gouty arthritis...
  13. ncbi A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy
    Akira Shoji
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 51:321-5. 2004
    ..To evaluate the proposed relationship between persistent reduction of serum urate into the subsaturating range and reduction in the frequency of acute gouty attacks...
  14. ncbi Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
    R Torres
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA
    Ann Rheum Dis 68:1602-8. 2009
    ..However, consequences of IL1 inhibition have not been explored in more clinically relevant models of crystal-induced arthritis...
  15. ncbi Clinical practice. Gout
    Robert A Terkeltaub
    Rheumatology Section, Department of Medicine, San Diego Veterans Affairs Medical Center and the University of California San Diego School of Medicine, San Diego, CA 92161, USA
    N Engl J Med 349:1647-55. 2003
  16. ncbi The pathogenesis of bone erosions in gouty arthritis
    Naomi Schlesinger
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Ann Rheum Dis 69:1907-12. 2010
    The characteristic radiographic hallmarks of chronic gouty arthritis are the presence of macroscopic tophi and erosions with overhanging edges and relative preservation of the joint space...
  17. ncbi The role of interleukin-1 and the inflammasome in gout: implications for therapy
    Richard M Pope
    Northwestern University Feinberg School of Medicine, and the Jesse Brown VA Medical Center, Chicago, Illinois 60611, USA
    Arthritis Rheum 56:3183-8. 2007
  18. pmc Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    Leo A B Joosten
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3237-48. 2010
    The concept that intraarticular crystals of uric acid by themselves trigger episodes of painful gouty arthritis is inconsistent with the clinical reality...
  19. ncbi Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
    Alexander So
    University Hospital of Lausanne, Lausanne, Switzerland
    Arthritis Rheum 62:3064-76. 2010
    To assess the efficacy and tolerability of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, for the treatment of acute gouty arthritis.
  20. ncbi An in vivo and in vitro potential of Indian ayurvedic herbal formulation Triphala on experimental gouty arthritis in mice
    E P Sabina
    School of Bio engineering and Biosciences, VIT University, Vellore 632 014, Tamil Nadu, India
    Vascul Pharmacol 48:14-20. 2008
    ..formulation Triphala on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, Indomethacin...
  21. ncbi Impact of sonography in gouty arthritis: comparison with conventional radiography, clinical examination, and laboratory findings
    Claudia Schueller-Weidekamm
    Department of Diagnostic Radiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Radiol 62:437-43. 2007
    To explore the typical sonographic features of gray-scale and Power Doppler of acute and chronic gouty arthritis in conjunction with radiographic, clinical, and laboratory findings.
  22. ncbi The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis
    Wako Urano
    The Institute of Rheumatology, Tokyo Women s Medical University, Japan
    J Rheumatol 29:1950-3. 2002
    To clarify the mechanism of decreased serum uric acid (SUA) concentrations during acute gouty arthritis.
  23. ncbi Management of acute and chronic gouty arthritis: present state-of-the-art
    Naomi Schlesinger
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903 0019, USA
    Drugs 64:2399-416. 2004
    ..of gout: (i) treating the acute attack; (ii) lowering excess stores of uric acid to prevent flares of gouty arthritis and to prevent tissue deposition of urate; and (iii) providing prophylaxis to prevent acute flares...
  24. ncbi Inflammatory pseudotumor of the liver complicated with recurrent gouty arthritis
    T Takahashi
    Department of Internal Medicine, Mikasa City Hospital, Mikasa
    Intern Med 40:493-8. 2001
    ..fever unresponsive to antibiotics developed in a 70-year-old man suffering from intractable recurrent gouty arthritis. 67Ga-scintigraphy disclosed intense focal uptake in the upper abdomen...
  25. ncbi Near-iron deficiency-induced remission of gouty arthritis
    Francesco S Facchini
    Department of Medicine, San Francisco General Hospital and University of California San Francisco, 94143, USA
    Rheumatology (Oxford) 42:1550-5. 2003
    ..The objective of the present study was to investigate whether or not iron removal may improve the outcome of gouty arthritis in humans as well.
  26. ncbi Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
    Stephen J Getting
    Immunopharmacology Unit, The William Harvey Research Institute, St Bartholomew s Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Arthritis Rheum 46:2765-75. 2002
    To test the hypothesis that local activation of melanocortin receptor(s) by adrenocorticotropic hormone (ACTH) could be responsible, at least in part, for its efficacy in human gouty arthritis.
  27. ncbi Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation
    Ru Liu-Bryan
    VA Medical Center, University of California, San Diego 92161, USA
    Arthritis Rheum 52:2936-46. 2005
    ....
  28. pmc The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
    R Terkeltaub
    VAMC Rheumatology, 111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Ann Rheum Dis 68:1613-7. 2009
    ..Recent studies suggest that blockade of the NLRP3 (cryopyrin) inflammasome interleukin 1beta (IL1beta) pathway may offer a new treatment strategy for gout...
  29. ncbi Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch
    Selim Nalbant
    University of Pennsylvania School of Medicine and the Arthritis Center, VA Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Rheumatol 32:1762-4. 2005
    ..To examine the ability of rofecoxib prophylaxis to blunt the effect of monosodium urate (MSU) crystal inflammation induced in the rat subcutaneous air pouch...
  30. ncbi Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase
    Yousuke Murakami
    Kitasato University School of Medicine, Sagamihara, Japan
    Arthritis Rheum 48:2931-41. 2003
    ..We evaluated the antiinflammatory effect of retrovirally transfected H-PGDS in order to investigate the role of H-PGDS in monosodium urate monohydrate (MSU) crystal-induced acute inflammation...
  31. ncbi Assessment of outcome in clinical trials of gout--a review of current measures
    W J Taylor
    Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, PO Box 7343, Wellington 6242, New Zealand
    Rheumatology (Oxford) 46:1751-6. 2007
    ..The absence of a valid definition of gout-flare or how flare reduction defines response is problematic; this forms the basis for a current ACR-EULAR sponsored project...
  32. pmc A pilot study of IL-1 inhibition by anakinra in acute gout
    Alexander So
    Service of Rhumatologie, Department of Medicine, Centre Hospitalier Universtaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
    Arthritis Res Ther 9:R28. 2007
    ..No adverse effects were observed. IL-1 blockade appears to be an effective therapy for acute gouty arthritis. The clinical findings need to be confirmed in a controlled study.
  33. pmc The inflammatory process of gout and its treatment
    Bruce N Cronstein
    Department of Medicine and Division of Clinical Pharmacology, New York University School of Medicine, New York, New York, USA
    Arthritis Res Ther 8:S3. 2006
    b>Gouty arthritis is a characteristically intense acute inflammatory reaction that erupts in response to articular deposits of monosodium urate (MSU) crystals...
  34. pmc Severe gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic option
    A K Tausche
    Ann Rheum Dis 63:1351-2. 2004
  35. pmc Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis
    H Ralph Schumacher
    Division of Rheumatology, University of Pennsylvania School of Medicine and Department of Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    BMJ 324:1488-92. 2002
    To assess the safety and efficacy of etoricoxib, a selective cyclo-oxygenase-2 inhibitor, in comparison with indometacin in the treatment of acute gouty arthritis.
  36. pmc Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine
    E W Chia
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Br J Pharmacol 153:1288-95. 2008
    When used to treat gouty arthritis, colchicine is believed to work by inhibiting microtubule-dependent cell infiltration. However, in vitro, colchicine also reduces monosodium urate (MSU)-induced superoxide production by neutrophils...
  37. ncbi Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout
    M D Feher
    Lipid Clinic, London SW10 9NH, UK
    Rheumatology (Oxford) 42:321-5. 2003
    ..To assess the short-term urate-lowering effect of fenofibrate in men on long-term allopurinol therapy for hyperuricaemia and gout...
  38. ncbi Effects of extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU crystal-induced rats gouty arthritis
    Ying Ma
    Department of Pharmacology, Anhui Medical University, Hefei 230032, China
    Am J Chin Med 37:669-83. 2009
    ....
  39. ncbi A single-blind, randomized, controlled trial to assess the efficacy and tolerability of rofecoxib, diclofenac sodium, and meloxicam in patients with acute gouty arthritis
    Tien Tsai Cheng
    Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan, Republic of China
    Clin Ther 26:399-406. 2004
    Acute attacks of gouty arthritis are characterized by the rapid onset of severe pain, swelling, and erythema of the affected joint. Nonsteroidal anti-inflammatory drugs are considered the drugs of first choice for treating acute gout...
  40. ncbi Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders
    Hung Pin Tu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Ann Rheum Dis 69:887-90. 2010
    ..To study the associations of gout, tophi and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single nucleotide polymorphisms (SNPs) between two different racial groups...
  41. ncbi A diagnostic rule for acute gouty arthritis in primary care without joint fluid analysis
    Hein J E M Janssens
    Department of Primary and Community Care, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Arch Intern Med 170:1120-6. 2010
    Most cases of acute gouty arthritis are diagnosed in primary care and without joint fluid analysis in many instances. Our objectives were to estimate the validity of this diagnosis by family physicians and to develop a diagnostic rule.
  42. ncbi Stimulation of inducible nitric oxide synthase by monosodium urate crystals in macrophages and expression of iNOS in gouty arthritis
    Linda Chen
    Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ROC
    Nitric Oxide 11:228-36. 2004
    ..To date, little is known about the role of iNOS in the pathophysiology of gouty arthritis (GA)...
  43. ncbi Frequency of gouty arthritis in patients with end-stage renal disease in Japan
    Iwao Ohno
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo
    Intern Med 44:706-9. 2005
    The purpose of this study was to investigate gouty arthritis in Japanese patients with end-stage renal disease (ESRD).
  44. pmc Severe gouty arthritis and mild neurologic symptoms due to F199C, a newly identified variant of the hypoxanthine guanine phosphoribosyltransferase
    Hang Korng Ea
    Hopital Lariboisiere, INSERM UMR S 606, Paris, France
    Arthritis Rheum 60:2201-4. 2009
    ..Herein, we describe a patient with hyperuricemia, juvenile-onset gouty arthritis, nephrolithiasis, and mild neurologic symptoms, attributed to a newly identified variant of the hprt gene, c...
  45. ncbi Gouty arthritis. A primer on late-onset gout
    Daniel Ene-Stroescu
    Internal Medicine Northwest, Tacoma, Washington, USA
    Geriatrics 60:24-31. 2005
    b>Gouty arthritis, a common source of pain and disability, is the most common form of inflammatory arthritis affecting older people...
  46. ncbi Gouty arthritis: not just a big toe problem
    S E Meiner
    University of Nevada in Las Vegas' College of Health Sciences, USA
    Geriatr Nurs 22:132-4. 2001
    ..High blood levels of uric acid lead to inflammation, joint swelling, and severe pain. Treatment is aimed at relieving the acute attack and preventing recurrent episodes of gouty arthritis.
  47. ncbi Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome
    Ru Liu-Bryan
    Department of Medicine, VA Medical Center, University of California, San Diego, CA, USA
    Immunol Cell Biol 88:20-3. 2010
    ..This review focuses on the critical role of intracellular NALP3 inflammasome in MSU crystal-induced inflammation...
  48. ncbi Local ice therapy during bouts of acute gouty arthritis
    Naomi Schlesinger
    Department of Medicine and New Jersey Medical School University of Medicine and Dentistry of New Jersey, Newark, USA
    J Rheumatol 29:331-4. 2002
    To evaluate the effect of local application of ice on duration and severity of acute gouty arthritis.
  49. ncbi Evil humors take their toll as innate immunity makes gouty joints TREM-ble
    Ru Liu-Bryan
    Arthritis Rheum 54:383-6. 2006
  50. ncbi Clinical manifestations of patients with hyperuricemia
    Somchai Akkasilpa
    Division of Rheumatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    J Med Assoc Thai 87:S41-4. 2004
    ..To study the clinical manifestations of patients with hyperuricemia in King Chulalongkorn Memorial Hospital...
  51. ncbi Diagnostic value of fine needle aspiration cytology in gouty tophi: a report of 7 cases
    Punam Prasad Bhadani
    Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal
    Acta Cytol 50:101-4. 2006
    ..Demonstration of monosodium urate (MSU) crystals in fine needle aspiration (FNA) smears from nodular masses clinically suspected to be tophi establishes the diagnosis unequivocally...
  52. ncbi An update on the treatment options for gout and calcium pyrophosphate deposition
    Gregory Choy
    Division of Rheumatology, University of Toronto, Sunnybrook and Women s College Health Science Centre, M1 401, Toronto, ON, M4N 3M5, Canada
    Expert Opin Pharmacother 6:2443-53. 2005
    ..Optimal treatment for both requires prompt resolution of acute synovitis, reduction of chronic joint damage and management of associated conditions. Available therapeutic interventions and future strategies are reviewed in this article...
  53. ncbi Crystal-induced arthropathies: recent investigative advances
    Michael H Ellman
    University of Chicago, Pritzker School of Medicine, Rheumatology Section, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Curr Opin Rheumatol 18:249-55. 2006
    ..To highlight recent investigations that have stimulated renewed interest in crystal-induced arthropathies...
  54. pmc A concise history of gout and hyperuricemia and their treatment
    George Nuki
    University of Edinburgh Rheumatic Diseases Unit, Scotland, UK
    Arthritis Res Ther 8:S1. 2006
    ....
  55. ncbi [Polyarticular gout in young adults: a curable rheumatic disease]
    A Pouye
    Clinique médicale I, CHU A Le Dantec
    Med Trop (Mars) 66:273-6. 2006
    ..Treatment is effective, well tolerated and inexpensive...
  56. ncbi [Pathogenesis, diagnostics and therapy of gout]
    M Zurek
    III Interní klinika Lékarské fakulty UP a FN Olomouc
    Vnitr Lek 52:736-41. 2006
    ..Gout manifests as acute gouty arthritis with classic clinical picture, or as chronic gouty arthropathy with periarticular and subcutaneous deposits ..
  57. ncbi [Diagnosis at a glance. This hand speaks volumes]
    Peter Stiefelhagen
    Internistischen Abteilung, DRK Klinikum Westerwald, Krankenhaus Hachenburg, D 57627 Hachenburg
    MMW Fortschr Med 148:57. 2006
  58. ncbi Advances in the management of gout and hyperuricaemia
    T K Hoskison
    Department of Internal Medicine, The University of Oklahoma College of Medicine Tulsa, 4502 East 41st Street, Tulsa, OK 74135, USA
    Scand J Rheumatol 35:251-60. 2006
    An acute attack of gouty arthritis is one of the most painful experiences reported throughout medical history. Therefore it is paramount to initiate appropriate therapy quickly in order to terminate the acute phase...
  59. ncbi Long-term cardiovascular mortality among middle-aged men with gout
    Eswar Krishnan
    Division of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Intern Med 168:1104-10. 2008
    There are limited data available on the association of gouty arthritis (gout) in middle age with long-term cardiovascular disease (CVD) mortality.
  60. ncbi [Molecular basis of primary renal hyperuricemia : role of the human urate transporter hURAT1]
    S Unger
    Bereich Pathologische Biochemie, Medizinische Klinik und Poliklinik III, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Dresden, Deutschland
    Z Rheumatol 66:556, 58-61. 2007
    ....
  61. ncbi [New knowledge on the pathophysiology and therapy of gout]
    A So
    Service de Rhumatologie, Département de Médicine, CHU Vaudois, University of Lausanne, 1011, Lausanne, Schweiz
    Z Rheumatol 66:562, 564-7. 2007
    ..The inflammatory effects of MSU are IL-1-dependent and can be blocked by IL-1 inhibitors. These advances provide new therapeutic targets to treat hyperuricemia and gout...
  62. ncbi [Antinociceptive effects of the combination metamizol + morphine in rats with intense pain (arthritic gout-type pain produced with AU)]
    Beatriz Godínez-Chaparro
    Departamento de Farmacobiologia, CINVESTAV Sede Sur, Mexico, D F, Mexico
    Cir Cir 75:371-6. 2007
    ..The antinociceptive effects of metamizol and morphine administered either separately or in combination were determined in the "Pain-Induced Functional Impairment Model in the Rat" (PIFIR antinociceptive model)...
  63. ncbi Spondyloarthritis as a presentation of gouty arthritis
    Maria Justiniano
    Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112 2282, USA
    J Rheumatol 34:1157-8. 2007
  64. ncbi Crystal-associated arthritis in the elderly
    Christopher M Wise
    Internal Medicine, Division of Rheumatology, Allergy, and Immunology, Medical College of Virginia, Virginia Commonwealth University Health System, 417 North 11th Street, Box 980647, Richmond, VA 23298, USA
    Rheum Dis Clin North Am 33:33-55. 2007
    ..The variable manifestations of crystal-induced arthritis in elderly populations has led to a greater need for proper diagnosis and treatment strategies for these increasingly common forms of arthritis...
  65. ncbi [Pathological mechanisms of gouty arthritis]
    Tohru Akahoshi
    Department of General Medicine, Kitasato University School of Medicine
    Nihon Rinsho 66:705-10. 2008
    ..Furthermore, pathological significance of NALP 3 inflammasome in gout has been also demonstrated. These findings provide a new insight into the mechanisms underlying the initiation of MSU crystal-induced acute inflammation...
  66. ncbi Updates in the management of gout
    Michael P Keith
    Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Med 120:221-4. 2007
    ..The clinical stages of gout include asymptomatic hyperuricemia, intermittent gouty arthritis, and chronic tophaceous gout...
  67. ncbi Crystal arthritis: contemporary approaches to diseases of antiquity
    Mark Lillicrap
    Department of Rheumatology, Hinchingbrooke Hospital NHS Trust, Huntingdon
    Clin Med 7:60-4. 2007
  68. ncbi Gout and related morbid conditions: pharmacological and SPA therapy
    L Petraccia
    Department of Clinics and Medical Therapy, Umberto I Hospital, University of Rome, La Sapienza, Rome, Italy
    Minerva Med 99:203-12. 2008
    b>Gouty arthritis is estimated to be the most frequent manifestation of inflammatory arthritis in men aged over 40...
  69. ncbi Crystal-associated synovitis- ultrasonographic feature and clinical correlation
    Danela Fodor
    2nd Internal Medicine and Rheumatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Ortop Traumatol Rehabil 10:99-110. 2008
    ..Therefore ultrasonography is useful in characterize the articular and juxta-articular alterations in crystal related diseases...
  70. ncbi Case 8: initiation of urate-lowering therapy for standard advanced gout
    J Michael Finley
    Department of Medicine, Western University College of Osteopathic Medicine of the Pacific, Pomona, California, USA
    Am J Med 119:S25-8. 2006
  71. ncbi Using serum urate levels to determine the period free of gouty symptoms after withdrawal of long-term urate-lowering therapy: a prospective study
    Fernando Perez-Ruiz
    Seccion de Reumatologia, Hospital de Cruces, Pais Vasco, Spain
    Arthritis Rheum 55:786-90. 2006
    Withdrawal of urate-lowering therapy (ULT) is associated with recurrence of acute gouty arthritis and tophi, but no data are available about factors associated with recurrence of gouty symptoms...
  72. ncbi Rapid induction of peroxisome proliferator-activated receptor gamma expression in human monocytes by monosodium urate monohydrate crystals
    Tohru Akahoshi
    Department of Laboratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Arthritis Rheum 48:231-9. 2003
    ..This study was undertaken to evaluate the biologic role of PPAR gamma in self-limiting episodes of acute gouty arthritis. To do this, we investigated PPAR gamma expression by monosodium urate monohydrate (MSU) crystal-stimulated ..
  73. pmc Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid
    J Vazquez-Mellado
    Rheumatology Service, Hospital General de Mexico, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    J Clin Pathol 60:947-8. 2007
  74. ncbi Does rofecoxib increase TNF-alpha levels?
    S Nalbant
    Gata Heh Iç Hastaliklari Servisi, Haydarpasa, Istanbul, Turkey
    Clin Exp Rheumatol 24:361-5. 2006
    ..However, this study was designed to study possible effects of rofecoxib on the level of TNF-alpha by using MSU crystal induced inflammation in the rat subcutaneous air pouch model...
  75. ncbi [European League Against Rheumatism evidence-based recommendations for diagnosis and management of gout]
    B Grusch
    Medizinische Abteilung, NO Zentrum für Rheumatologie, Landesklinikum Weinviertel Stockerau, Karl Landsteiner Institut für Klinische Rheumatologie, Landstrasse 18, 2000, Stockerau, Osterreich
    Z Rheumatol 66:568-72. 2007
    ..It constituted the primary goal of the EULAR project to deliver a substantial contribution to improve routine care of affected patients...
  76. ncbi Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis
    Wei Ji
    Rheumatism Immunity Department of The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine
    Chin J Integr Med 11:15-21. 2005
    To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism.
  77. ncbi [Diagnosis of gout]
    Eliseo Pascual Gómez
    Med Clin (Barc) 123:798. 2004
  78. ncbi [Colchicine]
    L Ben Slama
    Service de Stomatologie et de Chirurgie Maxillo Faciale, Hopital de la Salpetriere, 45, Bd de l Hopital, 75013 Paris, France
    Rev Stomatol Chir Maxillofac 103:128-9. 2002
  79. ncbi Gout and hyperuricemia
    Robert L Wortmann
    Department of Internal Medicine, The University of Oklahoma College of Medicine, Tulsa 74135, USA
    Curr Opin Rheumatol 14:281-6. 2002
    ..Uricosuric agents are also effective urate-lowering agents and provide an alternative to allopurinol. Strategies to treat patients who are sensitive to allopurinol continue to evolve...
  80. ncbi Diagnosing gouty arthritis
    David Kane
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary
    Practitioner 246:260-2, 264-5. 2002
  81. ncbi [Uric acid, a neglected molecule--the value of imaging]
    P Vock
    Institut für Diagnostische, Interventionelle und Pädiatrische Radiologie der Universität Bern, Inselspital, Bern
    Ther Umsch 61:557-62. 2004
    ..Gout of the musculoskeletal system usually manifests as an acute gouty arthritis after a long-standing asymptomatic hyperuricemia...
  82. pmc Hyperuricemia and urate nephropathy in urate oxidase-deficient mice
    X Wu
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 91:742-6. 1994
    ..the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones...
  83. ncbi Acute gout attack in the wrist joint
    Takeshi Kamimura
    Department of Medicine, Utsunomiya Social Insurance Hospital, Tochigi
    Intern Med 43:641-2. 2004
  84. ncbi Treatment of acute gouty arthritis: one physician's approach and where this management stands relative to developments in the field
    Robert L Wortmann
    Department of Internal Medicine, The University of Oklahoma College of Medicine, 4502 East 41st Street, Tulsa, OK 74137, USA
    Curr Rheumatol Rep 6:235-9. 2004
    An attack of acute gouty arthritis is one the most painful episodes that can be experienced by humans. Fortunately, there are three classes of agents that can effectively terminate the acute attack...
  85. ncbi The epidemiology of hyperuricemia in children of Taiwan aborigines
    Chiu Shong Liu
    Department of Family Medicine, Center of Community Health, China Medical College Hospital, Taichung, Taiwan
    J Rheumatol 30:841-5. 2003
    To explore the factors influencing serum uric acid concentrations and the prevalence of hyperuricemia in aboriginal children from an area in Taiwan with a high prevalence of gouty arthritis.
  86. ncbi [Gout and hyperuricaemia--should both be treated?]
    Till Uhlig
    Nasjonalt revmatologisk rehabiliterings og kompetansesenter, Revmatologisk avdeling, Diakonhjemmet sykehus, 0319 Oslo
    Tidsskr Nor Laegeforen 123:2878-80. 2003
    ..As prophylactic long-term treatment of recurring attacks, allopurinol, probenicide and colchicine are therapeutic alternatives. There is still no consensus on the treatment of individuals with asymptomatic hyperuricaemia...
  87. ncbi [Gout]
    W Grobner
    Kreisklinik Balingen, Akademisches Lehrkrankenhaus der Universität Tübingen, Tübinger Str 30, 72336, Balingen, Germany
    Z Rheumatol 63:2-9. 2004
    ..Prophylaxis of acute uric acid nephropathy consists of hydration, urine alkalinization and administration of allopurinol or rasburicase. For treatment of acute uric acid nephropathy rasburicase is the drug of choice...
  88. ncbi Gout: a clinical and radiologic review
    Johnny U V Monu
    Department of Musculoskeletal Radiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Radiol Clin North Am 42:169-84. 2004
    ..Acute episodes are treated with colchicine, NSAIDs, or steroids. Long-term management includes treatment with uricosuric agents or xanthine oxidase inhibitors...
  89. ncbi [Gout and its differential diagnosis]
    P M Villiger
    Klinik für Rheumatologie und Klinische Immunologie Allergologie, Universitatsspital Bern, Inselspital, Bern
    Ther Umsch 61:563-6. 2004
    ..Serum uric acid levels should be normalized in order to prevent recurrence of arthritis...
  90. ncbi Clinical analysis for the acupuncture treatment in 42 cases of gouty renal damage
    Xiaoping Ma
    Hai an County Hospital of Traditional Chinese Medicine, Jiangsu Province 226600
    J Tradit Chin Med 24:185-7. 2004
    ..To observe the therapeutic effects of acupuncture on gouty renal damage...
  91. ncbi Casebook: polyarthropathy
    David Coady
    Freeman Hospital, Newcastle upon Tyne
    Practitioner 246:715, 718, 721 passim. 2002
  92. ncbi Gout: diagnosis, pathogenesis, and clinical manifestations
    C A Agudelo
    Rheumatology Section, Emory University School of Medicine, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA
    Curr Opin Rheumatol 13:234-9. 2001
    ..Clinically, rare complications and disease manifestations in new populations continue to be discussed, and diagnostic methods continue to be refined...
  93. ncbi [Gout, colchicine and a couple of beers]
    Juan C Duró
    Med Clin (Barc) 123:798-9; author reply 799. 2004
  94. ncbi A swollen knee
    Richard P Usatine
    Florida State University College of Medicine, Tallahassee, FL 32306 4300, USA
    J Fam Pract 52:53-5. 2003
  95. ncbi [Gouty arthritis]
    Toshikazu Yamanouchi
    Department of Internal Medicine, Teikyo University School of Medicine
    Nihon Rinsho 61:213-8. 2003
  96. ncbi The incidence of gout in patients with Dupuytren's disease
    R F Adam
    Stafford District General Hospital
    J Hand Surg Br 17:219-20. 1992
    ..5%. The mean serum uric acid was 330 mumol/l. (5.5 mg./100 ml.) in men and 240 mumol./l. (4.0 mg./100 ml.) in women. The rate of hyperuricaemia was 7%. These are not significantly higher than the expected figures in Britain...
  97. ncbi Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    Wichittra Tassaneeyakul
    Departments of Pharmacology, Khon Kaen University, Khon Kaen, Thailand
    Pharmacogenet Genomics 19:704-9. 2009
    Allopurinol, a uric acid lowering drug commonly used for hyperuricemia and gouty arthritis, has been reported as a common cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome (SJS) and toxic ..
  98. ncbi The biochemical basis of the neurobehavioral abnormalities in the Lesch-Nyhan syndrome: a hypothesis
    Vladimir Kostadinov Neychev
    Department of Chemistry and Biochemistry, Medical University, 2 Zdrave Str, Sofia 1431, Bulgaria
    Med Hypotheses 63:131-4. 2004
    ..results in uric acid overproduction with subsequent hyperuricemia, nephrolithiasis, renal failure and gouty arthritis. In contrast, at complete HPRT deficiency, besides overproduction of uric acid neurological problems appear ..
  99. ncbi What do I need to know about gout?
    Michael A Becker
    Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA
    J Fam Pract 59:S1-8. 2010
    Many patients with gout present with an acute attack (flare) of gouty arthritis. In its early stages, gout is a chronic, often silent disorder punctuated by acute, extremely painful arthritic flares...
  100. ncbi The effect of control and self-medication of chronic gout in a developing country. Outcome after 10 years
    John Darmawan
    World Health Organization Collaborating Center, Community based Epidemiology, Prevention, and Treatment of Rheumatic Disease, Seroja Rheumatic Center, Jalan Seroja Dalam 7, Semarang 50136, Indonesia
    J Rheumatol 30:2437-43. 2003
    ..We describe a 10 year observation of the effect of control of hyperuricemia compared with self-medication alone in patients with chronic gout...
  101. ncbi Gout: an update
    Aaron T Eggebeen
    University of Pittsburgh Arthritis Institute, Pittsburgh, Pennsylvania 15261, USA
    Am Fam Physician 76:801-8. 2007
    Arthritis caused by gout (i.e., gouty arthritis) accounts for millions of outpatient visits annually, and the prevalence is increasing...

Research Grants22

  1. A Regulatory Checkpoint in the Pathogenesis of Inflammatory Arthritis
    Christian Stehlik; Fiscal Year: 2013
    ..plays a significant role in inflammation in a variety of forms of inflammatory arthritis, including gouty arthritis, Systemic-onset Juvenile idiopathic arthritis and adult-onset Still's disease and mediates synovial ..
  2. Impact of Unapproved Drug Initiative on Colchicine Use
    Eswar Krishnan; Fiscal Year: 2013
    7. Project Summary/Abstract High dose oral colchicine has been utilized for the treatment of acute gouty arthritis for several centuries...
  3. Preclinical Development of Uricase-PEG 20
    JOHN BOMALASKI; Fiscal Year: 2002
    Hyperuricemia (elevated serum uric acid) results in gouty arthritis and chronic renal disease...
  4. MUTATIONAL ANALYSIS OF A PARASITE PURINE SALVAGE ENZYME
    SYDNEY CRAIG; Fiscal Year: 2001
    ..absence HPRT activity is responsible for Lesch-Nyhan syndrome, while a partial deficiency can result in gouty arthritis. In contrast, most parasites are unable to synthesize purines via de novo pathways, and must rely on enzymes ..
  5. UNDERSTANDING THE DESIGN OF MOLECULAR MOTORS
    John Murray; Fiscal Year: 2000
    ..with microtubule-based motile systems have therapeutic applications in humans: colchicine, used for in gouty arthritis; vincristine, vinblastine, and taxol, used for their anti-mitotic effects against a variety of neoplasms; ..
  6. IDIOTYPES OF RHEUMATOID FACTORS
    George Moxley; Fiscal Year: 1990
    ..elevations of C3 anaphylatoxins in synovial fluids of patients with rheumatoid arthritis (RA) and acute gouty arthritis. The hypothesis to be examined in this proposal is that patients with RA produce rheumatoid factors (RFs) ..
  7. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  8. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  9. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  10. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  11. Innate Immunity in gouty Inflammation
    RU BRYAN; Fiscal Year: 2008
    ..Completion of this work will help further understanding the mechanisms of acute gouty inflammation, how to control gouty arthritis and potentially other forms of crystal-induced inflammation. [unreadable] [unreadable] [unreadable]
  12. NEUROBIOLOGY OF DYSTONIA
    HYDER JINNAH; Fiscal Year: 2008
    ..In addition, the studies will have direct relevance for modern neurosurgical approaches to the management of dystonia that involve focal brain stimulation or lesion techniques. [unreadable] [unreadable]..
  13. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  14. Neurobiology of Self-Injurious Behavior
    HYDER JINNAH; Fiscal Year: 2005
    ..These studies have direct relevance for understanding the neuroanatomical and neurochemical basis for self-injurious behavior and direct implications for a potential novel treatment strategy. ..
  15. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..concepts and evolving methodologies, this laboratory has kept returning over 4 decades to the study of acute gouty arthritis, both for its intrinsic importance and as a model of the acute inflammatory response...
  16. RA Comorbidity Bone Health in Men and African Americans
    Ted Mikuls; Fiscal Year: 2008
    ..Mikuls' continued development as an independent clinical investigator. ..
  17. Role of Flip Macrophages
    Richard Pope; Fiscal Year: 2007
    ..These studies will provide insights into mechanisms that contribute to the pathogenesis of RA and potentially the development of new therapeutic strategies. ..
  18. Molecular Identification of an Endogenous Adjuvant
    Yan Shi; Fiscal Year: 2006
    ..In all assays, the substance will be tested side by side with uric acid crystals for a direct comparison of their potencies. ..
  19. The biological relevance of adenosine deamination in immune activation
    Yan Shi; Fiscal Year: 2008
    ..This study deals with a new concept in immune regulation, and will have impact on vaccine development, autoimmune disease intervention and cancer immunotherapy. [unreadable] [unreadable] [unreadable] [unreadable]..
  20. ANDROGEN AS ADJUNCT THERAPY IN RHEUMATOID ARTHRITIS
    John Davis; Fiscal Year: 2002
    ..abstract_text> ..
  21. The role of Mcl-1 in the macrophages and RA
    Richard Pope; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page.................................................................................................................................................. 1 Description, ..