gout

Summary

Summary: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.

Top Publications

  1. ncbi Outcome domains for studies of acute and chronic gout
    H Ralph Schumacher
    Rheumatology Section, Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 36:2342-5. 2009
  2. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
  3. pmc Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    Reva C Lawrence
    NIH, Bethesda, Maryland, USA
    Arthritis Rheum 58:26-35. 2008
  4. pmc Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    PLoS Genet 5:e1000504. 2009
  5. ncbi Pathogenesis of gout
    Hyon K Choi
    Arthritis Research Centre of Canada, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Intern Med 143:499-516. 2005
  6. pmc Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout
    Ioannis Mitroulis
    First Department of Internal Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    PLoS ONE 6:e29318. 2011
  7. ncbi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:3136-41. 2011
  8. pmc Reliability and sensitivity of the self-report of physician-diagnosed gout in the campaign against cancer and heart disease and the atherosclerosis risk in the community cohorts
    Mara A McAdams
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21224, USA
    J Rheumatol 38:135-41. 2011
  9. ncbi Purine-rich foods, dairy and protein intake, and the risk of gout in men
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 350:1093-103. 2004
  10. ncbi SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
    Veronique Vitart
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Nat Genet 40:437-42. 2008

Detail Information

Publications344 found, 100 shown here

  1. ncbi Outcome domains for studies of acute and chronic gout
    H Ralph Schumacher
    Rheumatology Section, Veterans Affairs Medical Center, University and Woodland Avenues, Philadelphia, Pennsylvania 19104, USA
    J Rheumatol 36:2342-5. 2009
    Discussion and voting at OMERACT 9 confirmed 5 essential domains for outcomes of acute gout: pain, joint swelling, joint tenderness, patient global assessment and activity limitations...
  2. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and ..
  3. pmc Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    Reva C Lawrence
    NIH, Bethesda, Maryland, USA
    Arthritis Rheum 58:26-35. 2008
    ..of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as the symptoms of neck and back pain...
  4. pmc Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    PLoS Genet 5:e1000504. 2009
    Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes...
  5. ncbi Pathogenesis of gout
    Hyon K Choi
    Arthritis Research Centre of Canada, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Intern Med 143:499-516. 2005
  6. pmc Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout
    Ioannis Mitroulis
    First Department of Internal Medicine, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece
    PLoS ONE 6:e29318. 2011
    b>Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β)...
  7. ncbi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:3136-41. 2011
    To estimate the prevalence of gout and hyperuricemia based on the latest nationally representative sample of US men and women (National Health and Nutrition Examination Survey [NHANES] 2007-2008).
  8. pmc Reliability and sensitivity of the self-report of physician-diagnosed gout in the campaign against cancer and heart disease and the atherosclerosis risk in the community cohorts
    Mara A McAdams
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21224, USA
    J Rheumatol 38:135-41. 2011
    b>gout is often defined by self-report in epidemiologic studies. Yet the validity of self-reported gout is uncertain...
  9. ncbi Purine-rich foods, dairy and protein intake, and the risk of gout in men
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 350:1093-103. 2004
    Various purine-rich foods and high protein intake have long been thought to be risk factors for gout. Similarly, the possibility that the consumption of dairy products has a role in protecting against gout has been raised by metabolic ..
  10. ncbi SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
    Veronique Vitart
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Nat Genet 40:437-42. 2008
    ..About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate crystals in the joint...
  11. ncbi Gout
    Pascal Richette
    Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Federation de rhumatologie, Paris, France
    Lancet 375:318-28. 2010
    b>Gout is a common arthritis caused by deposition of monosodium urate crystals within joints after chronic hyperuricaemia. It affects 1-2% of adults in developed countries, where it is the most common inflammatory arthritis in men...
  12. pmc Uric acid transport and disease
    Alexander So
    Service de Rhumatologie, Department of Musculoskeletal Medicine, University of Lausanne, Lausanne, Switzerland
    J Clin Invest 120:1791-9. 2010
    ..Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, ..
  13. pmc EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:1312-24. 2006
    To develop evidence based recommendations for the management of gout.
  14. pmc Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    T C Hart
    University of Pittsburgh, School of Dental Medicine, Division of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Med Genet 39:882-92. 2002
    ..nephropathy (FJHN) are both autosomal dominant renal diseases characterised by juvenile onset of hyperuricaemia, gout, and progressive renal failure. Clinical features of both conditions vary in presence and severity...
  15. ncbi Independent impact of gout on mortality and risk for coronary heart disease
    Hyon K Choi
    Rheumatology Division, Arthritis Research Centre of Canada, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada
    Circulation 116:894-900. 2007
    Although gout and hyperuricemia are related to several conditions that are associated with reduced survival, no prospective data are available on the independent impact of gout on mortality...
  16. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
    Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors...
  17. pmc Fructose-rich beverages and risk of gout in women
    Hyon K Choi
    Section of Rheumatology and Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany St, Ste 200, Boston, MA 02118, USA
    JAMA 304:2270-8. 2010
    Fructose-rich beverages such as sugar-sweetened soda and orange juice can increase serum uric acid levels and, thus, the risk of gout, but prospective data on the relationship are limited.
  18. ncbi Gout and the risk of type 2 diabetes among men with a high cardiovascular risk profile
    H K Choi
    Department of Medicine, Division of Rheumatology, Vancouver General Hospital, Canada
    Rheumatology (Oxford) 47:1567-70. 2008
    Our objective was to evaluate the independent relation between a history of gout and the future risk of type 2 diabetes among men with a high cardiovascular risk profile.
  19. ncbi Update on gout: new therapeutic strategies and options
    Robert Terkeltaub
    Rheumatology Section, Veterans Affairs Medical Center, University of California, San Diego, 3350 La Jolla Village Drive, CA 92161, USA
    Nat Rev Rheumatol 6:30-8. 2010
    b>Gout, a disease recognized since antiquity, has increased in prevalence in recent years and the clinical profile of this disease has become increasingly complex, owing to large numbers of cases with iatrogenic factors, multiple ..
  20. pmc Mechanisms of inflammation in gout
    Nathalie Busso
    Service de Rheumatologie, Centre Hospitalier Universitaire Vaudois, Universite de Lausanne, Avenue Pierre Decker, 1011 Lausanne, Suisse
    Arthritis Res Ther 12:206. 2010
    An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation...
  21. ncbi Identification of low-frequency variants associated with gout and serum uric acid levels
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1127-30. 2011
    We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders, for association with gout and serum uric acid levels...
  22. pmc Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005
    L Annemans
    Ghent University, Faculty of Medicine, Department of Public Health, Ghent, Belgium
    Ann Rheum Dis 67:960-6. 2008
    To investigate and compare the prevalence, comorbidities and management of gout in practice in the UK and Germany.
  23. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
    The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8.0 mg/dL in a six-month trial.
  24. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
    ..recently used GWAS to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout, a consequence of elevated urate levels...
  25. ncbi Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, MA 02114, USA
    Arch Intern Med 165:742-8. 2005
    Limited prospective information exists on the relation between obesity and weight change and the risk of gout. Similarly, both hypertension and diuretic use have been considered risk factors for gout; however, their independent ..
  26. ncbi 2011 Recommendations for the diagnosis and management of gout and hyperuricemia
    Max Hamburger
    Rheumatology Associates of Long Island, Melville, NY 11747, USA
    Postgrad Med 123:3-36. 2011
    b>Gout is a major health problem in the United States; it affects 8.3 million people, which is approximately 4% of the adult population. Gout is most often diagnosed and managed in primary care physician practices...
  27. ncbi Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey
    Hyon K Choi
    Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Arthritis Rheum 57:109-15. 2007
    To determine the prevalence of metabolic syndrome among patients with gout and to examine the association between the 2 conditions in a nationally representative sample of US adults.
  28. pmc Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population
    Changgui Li
    the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
    PLoS ONE 7:e24561. 2012
    ..studies have identified genetic variants of SLC2A9 associated with urate concentrations and susceptibility to gout. We therefore investigated associations between gout and polymorphisms and haplotypes in the presumptive promoter ..
  29. ncbi Gout: an independent risk factor for all-cause and cardiovascular mortality
    Chang Fu Kuo
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kwei Shan Tao Yuan, Taiwan
    Rheumatology (Oxford) 49:141-6. 2010
    The relation of gout and hyperuricaemia to cardiovascular diseases has been well documented. This study investigates the survival impact of both gout and hyperuricaemia.
  30. ncbi Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, MA, USA
    Am J Med 125:679-687.e1. 2012
    The objective of this study was to estimate the latest prevalence of major comorbidities associated with gout and hyperuricemia in the US based on a recent, nationally representative sample of US men and women.
  31. ncbi Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993-96)
    H Y Chang
    Division of Health Policy Research, National Health Research Institutes, Nan-Kang, Taipei
    J Rheumatol 28:1640-6. 2001
    ..Information on self-reported, physician-diagnosed gout was also obtained...
  32. pmc Common dysfunctional variants in ABCG2 are a major cause of early-onset gout
    Hirotaka Matsuo
    Department of Integrative Physiology and Bio Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Sci Rep 3:2014. 2013
    b>Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty...
  33. pmc Independent impact of gout on the risk of acute myocardial infarction among elderly women: a population-based study
    Mary A De Vera
    Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada
    Ann Rheum Dis 69:1162-4. 2010
    Men with gout have been found to have an increased risk of acute myocardial infarction (AMI), but no corresponding data are available among women.
  34. ncbi Prevalence of contraindications and prescription of pharmacologic therapies for gout
    Robert T Keenan
    Section of Rheumatology of the New York Harbor Health Care System, New York Campus of the US Department of Veterans Affairs, New York, USA
    Am J Med 124:155-63. 2011
    Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied.
  35. ncbi The association of diabetes mellitus with liver, colon, lung, and prostate cancer is independent of hypertension, hyperlipidemia, and gout in Taiwanese patients
    Mei Yueh Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Metabolism 61:242-9. 2012
    ..the strong association of cancer and diabetes is independent from the influence of hypertension, dyslipidemia, and gout in the Taiwanese population...
  36. pmc Epidemiology of gout
    Edward Roddy
    Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Staffordshire ST5 5BG, UK
    Arthritis Res Ther 12:223. 2010
    b>Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades...
  37. ncbi Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials
    John S Sundy
    Duke Clinical Research Unit, Duke University Medical Center, Durham, North Carolina, USA
    JAMA 306:711-20. 2011
    Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition...
  38. pmc Gout epidemiology: results from the UK General Practice Research Database, 1990-1999
    T R Mikuls
    Department of Medicine, University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, USA
    Ann Rheum Dis 64:267-72. 2005
    To examine the epidemiology of gout and gout treatment in the United Kingdom using a large national practice based population.
  39. pmc EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:1301-11. 2006
    To develop evidence based recommendations for the diagnosis of gout.
  40. ncbi Gout medication treatment patterns and adherence to standards of care from a managed care perspective
    Chaitanya A Sarawate
    Health Outcomes Research, HealthCore, Inc, 800 Delaware Ave, Fifth Floor, Wilmington, DE 19801 1366, USA
    Mayo Clin Proc 81:925-34. 2006
    To determine allopurinol treatment patterns and adherence to published standards of care for patients with gout.
  41. ncbi British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout
    Kelsey M Jordan
    Rheumatology Department, Princess Royal Hospital, Brighton and Sussex University Hospitals Trust, UK
    Rheumatology (Oxford) 46:1372-4. 2007
  42. ncbi Gout: why is this curable disease so seldom cured?
    Michael Doherty
    Department of Rheumatology, City Hospital, Nottingham, UK
    Ann Rheum Dis 71:1765-70. 2012
    b>Gout is the most common inflammatory arthritis and one in which pathogenesis and risk factors are best understood. One of the treatment objectives in current guidelines is 'cure'...
  43. pmc Time required for disappearance of urate crystals from synovial fluid after successful hypouricaemic treatment relates to the duration of gout
    Eliseo Pascual
    Catedrático de Medicina Reumatología, Hospital General Universitario de Alicante, Maestro Alonso 109, 03010 Alicante, Spain
    Ann Rheum Dis 66:1056-8. 2007
    ..To determine whether hypouricaemic treatment results in the disappearance of urate crystals from gouty joints and to define the time required...
  44. ncbi Mechanisms of inflammation in gout
    N Dalbeth
    Eric Bywaters Centre, Faculty of Medicine, Imperial College London, UK
    Rheumatology (Oxford) 44:1090-6. 2005
  45. ncbi Febuxostat for the management of hyperuricaemia in patients with gout: a NICE single technology appraisal
    Matt Stevenson
    School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, South Yorkshire, UK
    Pharmacoeconomics 29:133-40. 2011
    ..for the clinical and cost effectiveness of febuxostat for the management of hyperuricaemia in patients with gout. The School of Health and Related Research Technology Appraisal Group (ScHARR-TAG) at the University of Sheffield ..
  46. ncbi NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout
    Flavio A Amaral
    Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Arthritis Rheum 64:474-84. 2012
    ..This study evaluated the role of the NLRP3 inflammasome and 5-lipoxygenase (5-LOX)-derived leukotriene B(4) (LTB(4) ) in driving tissue inflammation and hypernociception in a murine model of gout.
  47. pmc Patients and providers view gout differently: a qualitative study
    Leslie R Harrold
    Department of Medicine, University of Massachusetts Medical School, Meyers Primary Care Institute and Fallon Clinic, Worcester, USA
    Chronic Illn 6:263-71. 2010
    We sought to examine patients' and providers' views on the treatment of gout to better understand why management is suboptimal.
  48. ncbi Gout therapeutics: new drugs for an old disease
    Christopher M Burns
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Lancet 377:165-77. 2011
    ..by the European Medicines Agency and the US Food and Drug Administration heralds a new era in the treatment of gout. The use of modified uricases to rapidly reduce serum urate concentrations in patients with otherwise untreatable ..
  49. ncbi Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter?
    Eric Q Wu
    Analysis Group, Inc, Boston, Massachusetts 02199, USA
    J Rheumatol 36:1032-40. 2009
    We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly.
  50. ncbi Gender-specific risk factors for incident gout: a prospective cohort study
    Jiunn Horng Chen
    School of Medicine, China Medical University, Taichung, Taiwan
    Clin Rheumatol 31:239-45. 2012
    Previous reports suggested that gout incidence increased with serum uric acid (sUA) level. In addition to sUA, we aimed to examine the gender-specific risk factors for incident gout...
  51. ncbi Gout, allopurinol use, and heart failure outcomes
    George Thanassoulis
    Department of Medicine, McGill University Health Center, 687 Pine Ave W, Room A4 23, Montreal, QC H3A 1A1, Canada
    Arch Intern Med 170:1358-64. 2010
    Hyperuricemia is associated with reduced survival among patients with heart failure (HF), but the effect of gout on HF outcomes is unknown...
  52. ncbi Cellular characterization of the gouty tophus: a quantitative analysis
    Nicola Dalbeth
    University of Auckland, Auckland, New Zealand
    Arthritis Rheum 62:1549-56. 2010
    ..To characterize the cellular architecture of the tophus and to determine the presence of cytokines implicated in the initiation and resolution of gouty inflammation...
  53. ncbi Biochemical profile of idiopathic uric acid nephrolithiasis
    C Y Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 60:757-61. 2001
    ..The control group was composed of 54 with absorptive hypercalciuria and 2 normal subjects, matched with the UA stone group according to age, body mass index, and gender...
  54. pmc A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ..Hyperuricemia is associated with body mass index (BMI), sex, and multiple complex diseases including gout, hypertension (HTN), renal disease, and type 2 diabetes (T2D)...
  55. ncbi Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Arthritis Rheum 60:3485-92. 2009
    To examine the role of genetic variation in the renal urate transporter SLC2A9 in gout in New Zealand sample sets of Māori, Pacific Island, and Caucasian ancestry and to determine if the Māori and Pacific Island samples could be useful ..
  56. ncbi Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout
    Eswar Krishnan
    Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA
    Rheumatology (Oxford) 49:1229-38. 2010
    For many years, the relationship between cardiovascular disease risk and gout, though strong and consistent, was suspected of being coincidental rather than causative...
  57. pmc Impact of allopurinol use on urate concentration and cardiovascular outcome
    Li Wei
    Medicines Monitoring Unit MEMO, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 71:600-7. 2011
    ..To characterize patients with urate measurements by urate-lowering therapy (ULT) use and to study the impact of allopurinol treatment on cardiovascular and mortality outcomes...
  58. ncbi PEG-uricase in the management of treatment-resistant gout and hyperuricemia
    MERRY R SHERMAN
    Mountain View Pharmaceuticals, Inc, 3475 S Edison Way, Menlo Park, CA 94025, USA
    Adv Drug Deliv Rev 60:59-68. 2008
    ..Longstanding hyperuricemia can lead to gout, which is characterized by the deposition of monosodium urate monohydrate crystals in the joints and periarticular ..
  59. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
    Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout.
  60. ncbi SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular disease and diabetes...
  61. pmc Sex and age interaction with genetic association of atherogenic uric acid concentrations
    Anita Brandstätter
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schöpfstr 41, A 6020 Innsbruck, Austria
    Atherosclerosis 210:474-8. 2010
    High serum uric acid levels are associated with gout, atherosclerosis and cardiovascular disease. Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels.
  62. ncbi Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD)
    T R Mikuls
    Department of Medicine, Division of Clinical Immunology and Rheumatology, 510 20th Street South, FOT 8th Floor, Birmingham, AL 35294, USA
    Rheumatology (Oxford) 44:1038-42. 2005
    To examine adherence to validated quality indicators assessing the quality of allopurinol use in the treatment of gout and asymptomatic hyperuricaemia.
  63. pmc Developments in the scientific and clinical understanding of gout
    Alexander So
    Service de Rhumatologie, Departement de Medecine, CHU Vaudois, University of Lausanne, Ave Pierre Decker, 1011 Lausanne, Switzerland
    Arthritis Res Ther 10:221. 2008
    b>Gout is the most common form of inflammatory arthritis in the elderly. In the last two decades, both hyperuricemia and gout have increased markedly and similar trends in the epidemiology of the metabolic syndrome have been observed...
  64. ncbi Alcohol intake and risk of incident gout in men: a prospective study
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 363:1277-81. 2004
    The association between alcohol consumption and risk of gout has been suspected since ancient times, but has not been prospectively confirmed...
  65. pmc Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations
    Edward Roddy
    Academic Rheumatology, University of Nottingham, UK
    Ann Rheum Dis 66:1311-5. 2007
    To assess concordance of the management of chronic gout in UK primary care with the European League Against Rheumatism (EULAR) gout recommendations.
  66. ncbi Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
    J Li-Yu
    Department of Medicine, Hospital of the University of Pennsylvania, USA
    J Rheumatol 28:577-80. 2001
    To determine if lowering of serum uric acid (SUA) concentrations below 6 mg/dl or longer duration of lowered SUA will result in depletion of urate crystals from the knee joints and prevent further attacks of gout.
  67. ncbi Uric acid lowering therapy: prescribing patterns in a large cohort of older adults
    D H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Ann Rheum Dis 67:609-13. 2008
    Uric acid lowering therapy (UALT) is considered a chronic treatment for gout. Relatively little is known about adherence to UALT.
  68. ncbi Cardiovascular drugs and serum uric acid
    Ariel J Reyes
    Institute of Cardiovascular Theory, Montevideo, Uruguay
    Cardiovasc Drugs Ther 17:397-414. 2003
    ..The cardiovascular implications of the effects of drugs on SUA, if any, should be elucidated through purposive research...
  69. ncbi Determinants of the clinical outcomes of gout during the first year of urate-lowering therapy
    Michael A Becker
    Rheumatology Section, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    Nucleosides Nucleotides Nucleic Acids 27:585-91. 2008
    Clinical benefit early in urate-lowering treatment of gout is difficult to document...
  70. ncbi The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994
    Holly Mattix Kramer
    Renal Unit, Department of Medicine, Massachusetts General Hospital, USA
    Am J Kidney Dis 40:37-42. 2002
    b>Gout, an inflammatory arthritis, reportedly afflicts more than 2 million men and women in the United States...
  71. ncbi Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China
    Zhimin Miao
    Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao, China
    J Rheumatol 35:1859-64. 2008
    To demonstrate the prevalence of hyperuricemia and gout associated with dietary and lifestyle changes and evaluate the implication of metabolic disorders to the development of hyperuricemia.
  72. ncbi Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout
    John S Sundy
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 56:1021-8. 2007
    To evaluate the efficacy, immunogenicity, and tolerability of intravenous (IV) PEGylated recombinant mammalian urate oxidase (PEG-uricase) for the treatment of severe gout.
  73. ncbi Deaths associated with inappropriate intravenous colchicine administration
    Renan A Bonnel
    Office of Drug Safety, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, USA
    J Emerg Med 22:385-7. 2002
    ..Death occurred within 1 to 40 days after drug administration. Therapeutic guidelines exist for use of IV colchicine and these guidelines should be followed to prevent serious toxicities and death...
  74. pmc Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study
    Hyon K Choi
    Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    BMJ 344:d8190. 2012
    To determine the independent associations of antihypertensive drugs with the risk of incident gout among people with hypertension.
  75. ncbi Comparison of measures of functional disability in patients with gout
    Peter M ten Klooster
    Institute for Behavioural Research, Faculty of Behavioural Sciences, University of Twente, The Netherlands
    Rheumatology (Oxford) 50:709-13. 2011
    To compare the measurement properties of the HAQ disability index (HAQ-DI), HAQ-II and short form 36 physical functioning scale (PF-10) in patients with gout.
  76. pmc The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age
    Robert L Jackson
    Takeda Global Research and Development Centers, Inc, One Takeda Parkway, Deerfield, Illinois 60015, USA
    BMC Geriatr 12:11. 2012
    The incidence of gout rises with increasing age. Management of elderly (≥65 years) gout patients can be challenging due to high rates of comorbidities, such as renal impairment and cardiovascular disease, and concomitant medication use...
  77. ncbi Evaluation of an instrument assessing influence of Gout on health-related quality of life
    Jan D Hirsch
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 0714, USA
    J Rheumatol 35:2406-14. 2008
    To evaluate the reliability and validity of an instrument assessing the influence of gout (acute and chronic) on health-related quality of life (HRQOL).
  78. pmc Long-term therapy for chronic gout results in clinically important improvements in the health-related quality of life: short form-36 is responsive to change in chronic gout
    Puja P Khanna
    Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Rheumatology (Oxford) 50:740-5. 2011
    Short Form-36 (SF-36) is a validated outcome measure to assess health-related quality of life (HRQOL) in patients with gout. We assessed responsiveness to change of SF-36 in patients with gout.
  79. pmc Gout and subsequent increased risk of cardiovascular mortality in non-diabetics aged 50 and above: a population-based cohort study in Taiwan
    Victor C Kok
    Department of Biomedical Informatics, School of Computer Science, Asia University, Taichung, Taiwan
    BMC Cardiovasc Disord 12:108. 2012
    Limited data are available on the risk ratios for fatal cardiovascular disease (CVD) outcome from gout and chronic kidney disease (CKD) in non-diabetic individuals.
  80. ncbi Treatment adherence in patients with gout
    Gerard Reach
    EA 3412, CRNH IdF, Service d endocrinologie, Diabetologie, Maladies Metaboliques, Hopital Avicenne, AP HP, Universite Paris 13, Bobigny, France
    Joint Bone Spine 78:456-9. 2011
    The treatment objectives in gout are to promptly terminate the acute flares and to prevent the long-term complications via chronic pharmacotherapy, usually with urate-lowering drugs, combined with diet and lifestyle changes...
  81. ncbi Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: implication for altered bone remodeling in chronic gout
    Isabelle Allaeys
    Department of Medicine, Faculty of Medicine, Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL, Universite Laval, Quebec, Canada
    Lab Invest 91:905-20. 2011
    Bone destruction in chronic gout is correlated with deposits of monosodium urate (MSU) crystals. Bone with MSU tophi were histopathologically shown to have altered remodeling and cellular distribution...
  82. pmc The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity
    Jade E Hollis-Moffatt
    Department of Biochemistry, University of Otago, 710 Cumberland Street, Dunedin 9012, New Zealand
    Arthritis Res Ther 13:R85. 2011
    The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout...
  83. ncbi Epidemiology of gout: an update
    E U R Smith
    Department of Rheumatology, Northern Clinical School, University of Sydney, Building 35, Block 4, Level 4, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Best Pract Res Clin Rheumatol 24:811-27. 2010
    b>Gout is the most common inflammatory joint disease in men, characterised by formation of monosodium urate (MSU) crystals in the synovial fluid of joints and in other tissues...
  84. ncbi Gout and hyperuricemia
    Robert L Wortmann
    Department of Internal Medicine, The University of Oklahoma College of Medicine, Tulsa 74135, USA
    Curr Opin Rheumatol 14:281-6. 2002
    b>Gout continues to be a health problem around the world despite the availability of effective therapies...
  85. ncbi Japanese guideline for the management of hyperuricemia and gout: second edition
    Hisashi Yamanaka
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Nucleosides Nucleotides Nucleic Acids 30:1018-29. 2011
    b>Gout is a urate deposition disease caused by persistent hyperuricemia. Because gout patients present with a variety of clinical symptoms, it is necessary to have a guideline for the standard management and care of gout and hyperuricemia...
  86. pmc Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: Results from a cross-sectional survey
    Puja P Khanna
    University of Michigan, MI, USA
    Health Qual Life Outcomes 10:117. 2012
    The prevalence of gout is increasing, and most research on the associated burden has focused on serum urate (sUA) levels...
  87. ncbi Hyperuricemia, gout, and renal function after liver transplantation
    D A Neal
    Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke's NHS Trust, United Kingdom
    Transplantation 72:1689-91. 2001
    ..is a recognized complication of renal and cardiac transplantation, but the development of hyperuricemia and gout following liver transplantation have received less attention...
  88. pmc Risk factors for gout and prevention: a systematic review of the literature
    Jasvinder A Singh
    Medicine Service and Center for Surgical Medical Acute care Research and Transitions C SMART, Birmingham VA Medical Center, Birmingham, Alabama, USA
    Curr Opin Rheumatol 23:192-202. 2011
    Our objective was to perform a systematic review of risk factors and prevention of gout. We searched Medline for fully published reports in English using keywords including but not limited to 'gout', 'epidemiology', 'primary prevention', '..
  89. pmc Gout--current diagnosis and treatment
    Anne Kathrin Tausche
    Bereich Rheumatologie, Medizinische Klinik und Poliklinik III, Universitatsklinikum, Carl Gustav Carus an der TU Dresden, Dresden, Germany
    Dtsch Arztebl Int 106:549-55. 2009
    ..elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In Germany, the prevalence of gouty arthritis is estimated at 1...
  90. ncbi Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout
    Michael E Ernst
    Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Ther 31:2503-18. 2009
    Febuxostat, a nonpurine selective inhibitor of both the oxidized and reduced forms of xanthine oxidase, was approved in February 2009 by the US Food and Drug Administration for the management of hyperuricemia in adults with gout.
  91. pmc Adherence with urate-lowering therapies for the treatment of gout
    Leslie R Harrold
    Department of Medicine, The Meyers Primary Care Institute, Worcester, MA 01605, USA
    Arthritis Res Ther 11:R46. 2009
    Adherence to urate-lowering drugs (ULDs) has not been well evaluated among those with gout. Our aim was to assess the level and determinants of non-adherence with ULDs prescribed for gout.
  92. ncbi Renal function in gout: long-term treatment effects of febuxostat
    Andrew Whelton
    Universal Clinical Research Center, Inc, 1737 Beaver Brook Lane, Hunt Valley, MD 21030 1603, USA
    J Clin Rheumatol 17:7-13. 2011
    The association between hyperuricemia, gout, and impaired renal function has long been recognized...
  93. pmc Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Clin Nutr 87:1480-7. 2008
    Physical activity and cardiorespiratory fitness are not currently recognized as factors related to preventing gout, nor are risk factors for gout in physically active men well understood.
  94. pmc Contemporary epidemiology of gout in the UK general population
    Lucía Cea Soriano
    Spanish Centre for Pharmacoepidemiologic Research CEIFE, Almirante 28 2, 28004, Madrid, Spain
    Arthritis Res Ther 13:R39. 2011
    The objective of this study was to investigate the contemporary incidence of gout, examine potential risk factors, and evaluate specific gout treatment patterns in the general population.
  95. ncbi Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family
    N Kamatani
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Arthritis Rheum 43:925-9. 2000
    ..nephropathy (FJHN, MIM 162000) is an autosomal-dominant disease characterized by underexcretion-type hyperuricemia, gout, and chronic renal failure...
  96. ncbi Crystal-induced neutrophil activation
    Oana Popa-Nita
    Centre de Recherche en Rhumatologie et Immunologie du Centre de Recherche du CHUL CHUQ, Department of Microbiology and Immunology, Faculty of Medicine, Laval University, Quebec, Canada
    Immunol Cell Biol 88:32-40. 2010
    ..an integral part of this innate response and a key component of the acute inflammatory response associated with gout. A significant, though incomplete, body of information concerning the implication of human neutrophils in MSU ..
  97. ncbi The effect of serum urate on gout flares and their associated costs: an administrative claims analysis
    Rachel Halpern
    i3 Innovus, Eden Prairie, Minnesota 55344, USA
    J Clin Rheumatol 15:3-7. 2009
    Increased serum urate (sUA) levels (> or =6.0 mg/dL) are associated with increased likelihood of acute gout attacks, or "flares."
  98. ncbi New insights into the epidemiology of gout
    Michael Doherty
    Academic Rheumatology, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Rheumatology (Oxford) 48:ii2-ii8. 2009
    b>Gout is a true crystal deposition disease caused by formation of monosodium urate crystals in joints and other tissues. It is a common inflammatory arthritis that has increased in prevalence in recent decades...
  99. ncbi Gout in the elderly--a population health study
    John G Hanly
    Division of Rheumatology, Department of Medicine, Queen Elizabeth II Health Sciences Centre, College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 4K4, Canada
    J Rheumatol 36:822-30. 2009
    To determine the incidence, healthcare utilization, and costs in older adults with gout.
  100. pmc Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25
    Li Shu Chuan Cheng
    Division of Information Science, City of Hope Medical Center, Duarte, CA, USA
    Am J Hum Genet 75:498-503. 2004
    b>Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region...
  101. ncbi Gout and its comorbidities
    Michael H Pillinger
    New York University School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Bull NYU Hosp Jt Dis 68:199-203. 2010
    b>Gout is a chronic disease in which excessively high levels of serum urate (hyperuricemia) result in tissue depositions of sodium urate crystals and intermittent inflammatory attacks...

Research Grants62

  1. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..Americans, other forms of the disease are also prevalent, including rheumatoid arthritis, juvenile arthritis and gout. AR is associated with the breakdown of collagen and the production of inflammation-related factors such as ..
  2. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    b>Gout is a common and excruciatingly painful inflammatory arthritis associated with hyperuricemia. Gout represents a metabolically-driven arthropathy that could be substantially controlled through dietary and lifestyle modifications...
  3. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    JOHN PATTERSON ATKINSON; Fiscal Year: 2013
    ..As we age, lipids deposit in blood vessel walls (atherosclerosis), urate in joints (gout), amyloid proteins in the brain (Alzheimer's disease - AD) and lipofuscin pigments (drusen) in the retina (age-..
  4. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ..activation of the inflammasome has recently been linked to non-immune, metabolic diseases such as diabetes, gout, silicosis, and acetaminophen-induced liver toxicity...
  5. Cryopyrin/NLRP3 Signaling in Inflammation and Innate Immunity
    Gabriel Nunez; Fiscal Year: 2013
    ..in autoinflammatory syndromes and participates in the pathogenesis of several inflammatory disorders including gout, Crohn's disease, and diabetes...
  6. Outcomes Research in Rheumatic Diseases
    Dinesh Khanna; Fiscal Year: 2013
    ..In addition to directing a large Scleroderma program, I continue to work extensively in other arthritides (gout and rheumatoid arthritis) and have support of established clinical researchers in systemic lupus erythematosus and ..
  7. Development of inlammasome inhibitors to be used as anti-inflammatory agents
    Shyam Biswal; Fiscal Year: 2013
    ..Improper activation of the inflammasome has been implicated in multiple diseases, including gout, arthritis, diabetes, Alzheimer's, pulmonary fibrosis, and atherosclerosis...
  8. Pharmacogenomic Evaluation of Antihypertensive Responses
    Julie A Johnson; Fiscal Year: 2013
    ..BP) lowering with a given antihypertensive drug, some experience adverse metabolic effects and develop diabetes, gout or metabolic syndrome as a result of their therapy, and individual long-term outcomes vary despite equivalent BP ..
  9. Next-Generation Medical Resequencing of Gout Disease Genes in the ARIC Cohort
    James E Hixson; Fiscal Year: 2010
    ..next-generation sequencing for medical resequencing of genes that have shown highly significant associations with gout and serum uric acid levels in genome-wide association studies (GWAS) in the "Cohorts for Heart and Aging Research ..
  10. Role of urate in protecting mitochondrial function in the brain
    David K Simon; Fiscal Year: 2013
    ..the only established effects of high urate levels on health are pathological due to crystal formation in joints (gout) and kidney (stones)...
  11. Patient Centered Outcomes Research in Rheumatology
    DANIEL HAL SOLOMON; Fiscal Year: 2013
    ..EMR) database for three different rheumatic disease cohorts -- rheumatoid arthritis (RA), osteoarthritis (OA), and gout -- and then examine the agreement between databases...
  12. The role of cryopyrin in autoinflammatory diseases
    HAROLD M HOFFMAN; Fiscal Year: 2011
    ..in FCAS may play an important role in more common inflammatory disorders such as rheumatoid arthritis and gout. Our identification of CIAS1 and cryopyrin has brought attention to a new family of intracellular innate immune ..
  13. New Plasmodium Strategies to Modulate Inflammation
    Ana Rodriguez; Fiscal Year: 2009
    ..Uric acid is a well-known modulator of immune responses, as it is the causative agent of gout and has been identified as a danger signal for the immune system...
  14. Natural Substance Derivative DHNB is A Novel Xanthine Oxidase Inhibitor
    Changyi Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gout is caused by hyperuricemia, which is an abnormally high level of uric acid in the blood. Gout prevalence is about 3.9% for general population...
  15. Image Science for the New X-Ray: Taking Dual-Energy CT to Task
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..g., osteoarthritis, gout, soft-tissue and bone tumors, and tissue impingement syndromes).
  16. Role of NLR Inflammasomes in Autoinflammatory Diseases and Host Defense
    Thirumala Devi Kanneganti; Fiscal Year: 2013
    ..triggered by abnormal metabolic conditions that lead to the development of common debilitating disorders such as gout and type II diabetes mellitus...
  17. Improving Assessment of Physical Function and Drug Safety in Health and Disease
    Eswar Krishnan; Fiscal Year: 2013
    ..these domains in rheumatoid arthritis, osteoarthritis, lupus, scleroderma, juvenile arthritis, vasculitis, and gout patients, in frailty/aging, nursing home, and positive health populations, as well as populations that may become ..
  18. Mechanisms of Dinitroaniline Action, Selectivity and Resistance
    Naomi S Morrissette; Fiscal Year: 2010
    ..Compounds that affect MT function are used to treat medical conditions including cancer, gout and helminth infection...
  19. Centers of Research Translation (CoRT)
    Kenneth G Saag; Fiscal Year: 2013
    b>Gout affects ~1 to 2% of the U.S. population. With an aging population, the societal burden of gout will likely grow...
  20. Assessing and Improving Arthritis Medication Adherence: Gout as a Model
    Leslie R Harrold; Fiscal Year: 2011
    ..The consequences of poor adherence have not been well explored in arthritis and musculoskeletal conditions. Gout is an ideal condition in which to examine lack of adherence as it affects up to 5 million Americans, and its ..
  21. Factors influencing change in 24 hour urine composition
    Gary C Curhan; Fiscal Year: 2013
    ..risk factors for a variety of conditions including nephrolithiasis, hypertension, cardiovascular disease and gout. He is studying dietary, lifestyle factors, genetic contributions and biomarkers in large cohort studies based at ..
  22. Mid-Career Investigator Award (for Kenneth G. Saag, MD, MSc)
    Kenneth G Saag; Fiscal Year: 2013
    ..of osteoporosis examining adherence, comparative effectiveness, and bisphosphonate safety;and gout epidemiology...
  23. Risk Factors for Gout Among Women
    Hyon Choi; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Gout is a common and excruciatingly painful inflammatory arthritis associated with hyperuricemia...
  24. Impact of Unapproved Drug Initiative on Colchicine Use
    Eswar Krishnan; Fiscal Year: 2013
    ..the impact of the Colcrys(R) approval, the related media publicity and the Phase 2 and 3 study data in real world gout flare treatment...
  25. MEMBRANE-LIMITED METABOLISM IN MAMMALIAN RED CELLS
    Hyun Kim; Fiscal Year: 1990
    ..of purine metabolism will shed more light on the pathogenesis of such human diseases as Lesch-Nyhan syndrome, gout and certain immune deficiencies...
  26. MOLECULAR MECHANISMS OF PRPP-SYNTHETASE OVERACTIVITY
    Blake Roessler; Fiscal Year: 1991
    ..in erythrocytes is assoicated with an X-linked syndrome consisiting of hyperuricemia, hyperuricaciduria, precocious gout and nephrolithiasis. Several of these mutant forms of PRPP-S have been partially characterized...
  27. MOLECULAR MECHANISMS OF PRPP-SYNTHETASE OVERACTIVITY
    THOMAS PALELLA; Fiscal Year: 1990
    ..in erythrocytes is assoicated with an X-linked syndrome consisiting of hyperuricemia, hyperuricaciduria, precocious gout and nephrolithiasis. Several of these mutant forms of PRPP-S have been partially characterized...
  28. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..Uric acid levels are a contributing factor for many human diseases including gout, kidney stones, cardiovascular and renal disease...
  29. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..is notable that MS patients most often have lower serum UA levels than age- and sex- matched healthy controls and gout (hyperuricemia) patients rarely, if ever, develop MS...
  30. GLUTAMINE AMIDOTRANSFERASE STRUCTURE/FUNCTION/REGULATION
    Howard Zalkin; Fiscal Year: 1991
    ..This B. subtilis enzyme is a good model for the presently unavailable human enzyme, which may have a role in gout. (v) Cloning and sequence analysis of aconitase cDNA will initiate studies on a second (4Fe- 4S) enzyme and will ..
  31. SYNTHETIC APPLICATIONS OF CARBENE COMPLEXES
    WILLIAM WULFF; Fiscal Year: 2003
    ..D and for the synthesis of colchicine and allocolchicinoids that have been investigated for the treatment of gout, familial Mediterranean fever and liver cirrhosis...
  32. Genotype and Phenotype of Familial Nephropathy with Gout
    Mary Marazita; Fiscal Year: 2005
    Familial Nephropathy with Gout (FGN) is a rare kidney disorder characterized by reduced fractional excretion of uric acid, precocious and tophaceous gout, and development of chronic renal failure leading to end-stage renal disease...
  33. INORGANIC PYROPHOSPHATE METABOLISM IN ARTHRITIS
    Lawrence Ryan; Fiscal Year: 2006
    ..Prevalence approaches 50 percent in those over 80. CPPD crystals cause acute attacks of gout-like arthritis, but more importantly are associated with debilitating degenerative arthritis...
  34. Transition-State Inhibitors of Fatty Acid Synthase
    Jerry Skiles; Fiscal Year: 2006
    ..obesity has been associated with stroke, hypertension, heart disease, gallbladder disease, sleep apnea and other breathing problems, gout, certain [unreadable] types of cancers, osleoarthritis, and depression. [unreadable] [unreadable]
  35. The Multi-Cellular Basis of Urate-induced Arthropathies
    PAUL NACCACHE; Fiscal Year: 2009
    ..the mechanisms of activation of human neutrophils by urate crystals and the generation of the symptoms of acute gout attacks, 21 to investigate the modulation of the immune responses by urate crystals and its role in the ..
  36. UAB CERT OF MUSCULOSKELETAL DISORDERS
    Kenneth Saag; Fiscal Year: 2006
    ..study followed by a randomized trial of a direct to patient intervention to improve safety in gout treatment (Supplemental Module 2); c...
  37. MECHANISM OF ACTION OF COLCHICINE
    YI HAN CHANG; Fiscal Year: 1980
    ..it is the objective of this investigation to determine 1) whether polymorphonuclear leukocytes in patients with gout and in laboratory animals with acute experimental inflammation are functionally abnormal in terms of chemotaxis, ..
  38. HMO Research Network CERT 2
    Richard Platt; Fiscal Year: 2006
    ..to beta-blockers after MI (with the Duke CERT), and another to stimulate initiation of urate lowering therapy for gout (with the UAB CERT); 4) assess medication errors in ambulatory cancer care (with the NIH Cancer Research Network); ..
  39. REGULATION OF PURINE NUCLEOTIDE SYNTHESIS IN HUMANS
    Michael Becker; Fiscal Year: 2001
    ..of inherited enzyme defects underlying excessive purine nucleotide and uric acid production in some families with gout have contributed to concepts of the control of rates of purine synthesis de novo...
  40. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  41. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  42. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  43. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
  44. Uric Acid and Hypertension in African-Americans
    Mark Segal; Fiscal Year: 2008
    ..by applicant): Thiazide diuretics are associated with many metabolic side effects including hyperuricemia, gout, insulin resistance, and hyperlipidemia. These very conditions are already highly prevalent in African-Americans...
  45. RA Comorbidity Bone Health in Men and African Americans
    Ted Mikuls; Fiscal Year: 2008
    ..Mikuls' continued development as an independent clinical investigator. ..
  46. GENETIC MODELS TO STUDY ALCOHOL TOXICITY
    Vasilis Vasiliou; Fiscal Year: 2003
    ..These studies will greatly enhance our understanding of genetic factors involved in alcohol toxicity. ..
  47. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004
    ....
  48. IL-8 in chondrocalcinosis
    RU BRYAN; Fiscal Year: 2005
    ..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
  49. Innate Immunity in gouty Inflammation
    RU BRYAN; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): In gout, monosodium urate (MSU) crystals deposited in the joint stimulate both acute neutrophilic inflammation and chronic synovitis that may lead to bone and cartilage destruction...
  50. A LYMPHOBLAST MODEL FOR DISEASES OF PURINE METABOLISM
    Michael Hershfield; Fiscal Year: 2006
    ..abstract_text> ..
  51. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  52. GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIA
    Harold Hoffman; Fiscal Year: 2002
    ..The achievement of these goals will result in identification of the gene responsible for familial cold urticaria which will ultimately lead to an understanding of the mechanism of the inflammatory response to a physical stimulus. ..
  53. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..