Genomes and Genes
Summary: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
Articles from Journal RESEARCH
Articles from Journal RESEARCH2
Publications342 found, 100 shown here
- Risk factors for statin-associated rhabdomyolysisStephanie Schech
Center for Health Care Policy and Evaluation, Eden Prairie, MN 55344, USA
Pharmacoepidemiol Drug Saf 16:352-8. 2007To identify and characterize risk factors for rhabdomyolysis in patients prescribed statin monotherapy or statin plus fibrate therapy.
- Rhabdomyolysis: a review of the literatureF Y Khan
Department of Medicine, Hamad General Hospital, Doha, Qatar
Neth J Med 67:272-83. 2009b>Rhabdomyolysis is a potentially life-threatening syndrome that can develop from a variety of causes; the classic findings of muscular aches, weakness and tea-coloured urine are non-specific and may not always be present...
- Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic featuresGianfranco Cervellin
U O Pronto Soccorso e Medicina d Urgenza, Dipartimento di Emergenza Urgenza, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
Clin Chem Lab Med 48:749-56. 2010b>Rhabdomyolysis, a term used to describe the rapid breakdown of striated muscle, is characterized by rupture and necrosis of muscle fibers...
- Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigreesM Davis
Department of Neuropathology, Royal Perth Hospital, Western Australia
Br J Anaesth 88:508-15. 2002..Two of these cases also show evidence of exercise-induced rhabdomyolysis. In each case MH susceptibility was confirmed by in vitro contracture testing of quadriceps muscle...
- The other medical causes of rhabdomyolysisRonald C Allison
Division of Pulmonary andCritical Care Medicine, Department of Internal Medicine, University of South Alabama College of Medicine, Medical Center, 2451 Fillingim Street, Suite 10 G, Mobile, AL 36617, USA
Am J Med Sci 326:79-88. 2003b>Rhabdomyolysis is the clinical and laboratory syndrome resulting from skeletal muscle injury and release of potentially toxic substances into the circulation...
- Cerivastatin, genetic variants, and the risk of rhabdomyolysisKristin D Marciante
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Pharmacogenet Genomics 21:280-8. 2011The withdrawal of cerivastatin involved an uncommon but serious adverse reaction, rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of users, points to genetic factors as a potential cause...
- Rhabdomyolysis: a reviewJason D Warren
Department of Neurology, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Muscle Nerve 25:332-47. 2002b>Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements ..
- Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same?Marc Evans
University Hospital of Wales, Heath Park, Cardiff, Wales
Drug Saf 25:649-63. 2002..involving skeletal muscle being the most common, ranging from mild myopathy to myositis and occasionally to rhabdomyolysis and death...
- Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic reviewKarina Rodriguez-Capote
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Clin Chem 55:2190-7. 2009Urine myoglobin continues to be used as a marker of rhabdomyolysis, particularly to assess risk of developing acute renal failure and evaluate treatment success...
- Acute kidney injury due to rhabdomyolysis in H1N1 influenza infectionSelman Unverdi
Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey
Ren Fail 33:450-1. 2011..were documented for elevation of creatinine phosphokinase levels in the course of influenza infection, but rhabdomyolysis was rarely reported...
- Adverse effects of statins - mechanisms and consequencesJerzy Bełtowski
Department of Pathophysiology, Medical University, Lublin, Poland
Curr Drug Saf 4:209-28. 2009..Myopathy is the most frequent side effect of statins and in some cases may have a form of severe rhabdomyolysis. Less common adverse effects include hepatotoxicity, peripheral neuropathy, impaired myocardial contractility ..
- Rhabdomyolysis following dengue virus infectionM Lim
Department of Emergency Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
Singapore Med J 46:645-6. 2005..The patient was found to have raised serum creatine kinase levels, consistent with rhabdomyolysis. He was treated with intravenous hydration and recovered uneventfully...
- RhabdomyolysisW H Bagley
Department of Emergency Medicine, St Luke s Roosevelt Hospital, University Hospital of Columbia Physicians and Surgeons, New York, NY 10025, USA
Intern Emerg Med 2:210-8. 2007b>Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle causing myoglobin and other intracellular proteins and electrolytes to leak into the circulation...
- Rhabdomyolysis associated with dengue virus infectionJoshua S Davis
Infectious Diseases Department, John Hunter Hospital, Newcastle, Australia
Clin Infect Dis 38:e109-11. 2004We describe 2 patients who developed rhabdomyolysis due to dengue virus infection. The first patient recovered with no sequelae, but the second developed multiple organ failure and died...
- Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case reportJianyong Wu
Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hanghzou, 310003, Zhejiang, People s Republic of China
Eur J Clin Pharmacol 65:1169-74. 2009Fibrates are used to manage mixed dyslipidemia. However, these drugs have the potential risk of inducing rhabdomyolysis. This paper gives an overview of the literature on rhabdomyolysis associated with fibrate therapy.
- Pathogenesis and treatment of renal dysfunction in rhabdomyolysisS G Holt
Centre for Nephrology and Transplantation, Royal Free Hospital, Hampstead, London, UK
Intensive Care Med 27:803-11. 2001b>Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction...
- Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?Carlos V R Brown
Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California, USA
J Trauma 56:1191-6. 2004..of bicarbonate and mannitol (BIC/MAN) is commonly used to prevent renal failure (RF) in patients with rhabdomyolysis despite the absence of sufficient evidence validating its use...
- Etiology and frequency of rhabdomyolysisCorri Black
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
Pharmacotherapy 22:1524-6. 2002To describe the etiology and characteristics of patients with clinically diagnosed rhabdomyolysis in the United Kingdom General Practice Research Database (GPRD), and to estimate the risk of rhabdomyolysis in general and that associated ..
- Influenza B-associated rhabdomyolysis in Taiwanese childrenC T Wu
Division of Pediatric Emergency Medicine, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tauyuan, Taiwan
Acta Paediatr 99:1701-4. 2010Influenza B-associated rhabdomyolysis (IBAR) is an infrequent and little-known complication of influenza B virus infection in children...
- Serum creatine kinase as predictor of clinical course in rhabdomyolysis: a 5-year intensive care surveyArthur R de Meijer
Department of Intensive Care, Meander Medical Centre, P O Box 1502, 3800 BM, Amersfoort, The Netherlands
Intensive Care Med 29:1121-5. 2003To evaluate the risk factors for the development of acute renal failure (ARF) in severe rhabdomyolysis.
- Pressure-induced rhabdomyolysis after bariatric surgeryGonzalo Torres-Villalobos
Department of Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Obes Surg 13:297-301. 2003..Obesity has been reported as a risk factor for pressure-induced rhabdomyolysis, but no reports associated with bariatric surgery could be found in the literature...
- Elevated serum cardiac troponin I in rhabdomyolysisGopikrishna Punukollu
Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA
Int J Cardiol 96:35-40. 2004To examine the etiology and clinical significance of elevated serum cardiac troponin I (cTnI) in patients with rhabdomyolysis.
- Acute encephalopathy and multi-organ involvement with rhabdomyolysis during primary HIV infectionMiltiadis Douvoyiannis
Department of Pediatrics, Division of Pediatric Infectious Diseases, Children s Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Avenue, Rosenthal 4th Floor, Bronx, NY 10467, USA
Int J Infect Dis 13:e299-304. 2009An adolescent male developed encephalopathy and multiple organ involvement with rhabdomyolysis during primary HIV infection (PHI). All symptoms and signs resolved within a few days...
- Serum myoglobin and renal morbidity and mortality following thoracic and thoraco-abdominal aortic repair: does rhabdomyolysis play a role?C C Miller
Department of Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA
Eur J Vasc Endovasc Surg 37:388-94. 2009..We studied postoperative myoglobinaemia and renal dysfunction following aortic surgery...
- Acute kidney injury after coronary artery bypass grafting: does rhabdomyolysis play a role?Umberto Benedetto
Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S Andrea, Rome, Italy
J Thorac Cardiovasc Surg 140:464-70. 2010In clinical situations in which rhabdomyolysis is common, renal dysfunction association with myoglobinemia is well described...
- Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injuryQingqing Wei
Dept of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
Am J Physiol Renal Physiol 301:F162-70. 2011..b>Rhabdomyolysis is another important clinical cause of AKI, due to the release of nephrotoxins (e.g...
- Outcomes in 45 patients with statin-associated myopathyKaren E Hansen
Rheumatology Section, University of Wisconsin Medical School, H6 363 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
Arch Intern Med 165:2671-6. 2005..Furthermore, long-term outcomes and responses to statin rechallenge in patients with statin-associated myopathy are largely unknown...
- Prognostic value, kinetics and effect of CVVHDF on serum of the myoglobin and creatine kinase in critically ill patients with rhabdomyolysisT S Mikkelsen
Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark
Acta Anaesthesiol Scand 49:859-64. 2005I) To investigate the kinetics of the myoglobin and creatine kinase (CK) in rhabdomyolysis. Especially to describe those patients in whom an isolated increase in the myoglobin or the CK occurred at a later stage...
- Prevention of rhabdomyolysis in bariatric surgeryJoão Eduardo Marques Tavares de Menezes Ettinger
Bariatric Surgery Division, São Rafael Hospital, Salvador, Bahia, Brazil
Obes Surg 15:874-9. 2005b>Rhabdomyolysis (RML) is a clinical and biochemical syndrome caused by skeletal muscle necrosis that results in extravasation of toxic intracellular contents from the myocytes into the circulatory system...
- A case of late onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting as recurrent rhabdomyolysis and acute renal failureRumiko Izumi
Department of Neurology, Tohoku University School of Medicine, Japan
Intern Med 50:2663-8. 2011..riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD) characterized by episodic recurrent rhabdomyolysis and acute renal failure after the age of 46...
- Use of RIFLE criteria to predict the severity and prognosis of acute kidney injury in emergency department patients with rhabdomyolysisKathleen A Delaney
University of Texas Southwestern Medical School, Parkland Memorial Hospital, Dallas, Texas 75930 8579, USA
J Emerg Med 42:521-8. 2012RIFLE criteria (Risk, Injury, Failure, Loss, End-stage) have not been evaluated in Emergency Department (ED) patients at risk of acute kidney injury (AKI). AKI occurs in rhabdomyolysis.
- Incidence of hospitalized rhabdomyolysis with statin and fibrate use in an insured US populationKandace L Amend
Epidemiology Division, OptumInsight, Ann Arbor, MI, USA
Ann Pharmacother 45:1230-9. 2011The incidence of hospitalized rhabdomyolysis is not well characterized among patients taking statin-fibrate combination therapies.
- Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgiaCaroline Michot
Paris Descartes University, INSERM U781 and Reference Center of Metabolic Diseases, Necker Hospital, Paris, France
J Inherit Metab Dis 35:1119-28. 2012Recessive LPIN1 mutations were identified as a cause of severe rhabdomyolysis in pediatric patients. The human lipin family includes two other closely related members, lipin-2 and 3, which share strong homology and similar activity...
- Primary aldosteronism associated with severe rhabdomyolysis due to profound hypokalemiaAtsushi Goto
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Tokyo
Intern Med 48:219-23. 2009..levels (15,760 IU/L), suggesting that the patient had hypokalemic paralysis and hypokalemia-induced rhabdomyolysis. Further evaluations, including adrenal venous sampling strongly suggested that he had primary aldosteronism...
- Toxicity of myoglobin and haemoglobin: oxidative stress in patients with rhabdomyolysis and subarachnoid haemorrhageB J Reeder
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
Biochem Soc Trans 30:745-8. 2002Haemolytic events, such as those following rhabdomyolysis and subarachnoid haemorrhage, often result in pathological complications such as vasoconstriction...
- Rhabdomyolysis: a review, with emphasis on the pediatric populationEssam F Elsayed
Department of Internal Medicine, Section of Nephrology, VA North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Pediatr Nephrol 25:7-18. 2010b>Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA...
- RhabdomyolysisD Singh
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
Methods Find Exp Clin Pharmacol 27:39-48. 2005b>Rhabdomyolysis is a condition caused by skeletal muscle injury and release of muscle cell contents into the circulation...
- Laparoscopic renal surgery and the risk of rhabdomyolysis: diagnosis and treatmentKaren E Reisiger
Division of Urology, Washington University School of Medicine, Saint Louis, Missouri, USA
Urology 66:29-35. 2005Postoperative rhabdomyolysis is a rare but serious complication of laparoscopic renal urologic surgery...
- Cocaine/heroin induced rhabdomyolysis and ventricular fibrillationB McCann
Emergency Department, Royal Liverpool University Hospital, Liverpool, UK
Emerg Med J 19:264-5. 2002..The arrest is attributed primarily to hyperkalaemia/rhabdomyolysis-a recognised consequence of each of these drugs. The administration of naloxone may have been contributory...
- The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermiaJohn F Capacchione
Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Anesth Analg 109:1065-9. 2009Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia (MH) are complex syndromes with similar pathophysiology...
- Cobalt protoporphyrin protects against hepatic parenchymal injury and microvascular dysfunction during experimental rhabdomyolysisRobert B Dorman
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Shock 23:275-80. 2005Although heme is necessary in many life-sustaining functions, its overwhelming systemic release with rhabdomyolysis (RM) is believed to be the cause of subsequent organ injury and dysfunction...
- Trabectedin-related rhabdomyolysis: an uncommon but fatal toxicityAikaterini Stoyianni
Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
Tumori 97:252-5. 2011b>Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome...
- Exertional Rhabdomyolysis during a 246-km continuous running raceKaterina P Skenderi
Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
Med Sci Sports Exerc 38:1054-7. 2006..To evaluate the effect of continuous, moderate-intensity ultra-endurance running exercise on skeletal muscle and hepatic damage, as indicated by serum enzyme activity measured immediately following the race...
- Rhabdomyolysis in falciparum malaria--a series of twelve cases (five children and seven adults)Saroj K Mishra
Department of Internal Medicine, Ispat General Hospital, Rourkela 769 005, Orissa, India
Trop Doct 40:87-8. 2010There are very few reports in the literature of rhabdomyolysis in falciparum malaria and they mostly consist of single case studies. A report from Sri Lanka described a single patient with myoglobinuria and skeletal muscle necrosis...
- Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis and rhabdomyolysisKarkal Ravishankar Naik
Department of Neurology, Jawaharlal Nehru Medical College and KLES Dr Prabhakar Kore Hospital and MRC, Nehrunagar, Belgaum, Karnataka 590010, India
J Neurol Sci 291:5-11. 2010Neurological manifestations secondary to extrapontine myelinolysis and rhabdomyolysis caused by hypernatremia are infrequently reported...
- Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysisF Wappler
Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
Anesthesiology 94:95-100. 2001Malignant hyperthermia (MH), heat stroke, and exercise-induced rhabdomyolysis (ER) were suspected to be related syndromes. However, it is not known whether individuals with history of ER have an increased incidence of susceptibility to MH...
- Novel single base pair COX III subunit deletion of mitochondrial DNA associated with rhabdomyolysisRosetta Marotta
St Vincent s Melbourne Neuromuscular Diagnostic Laboratory, Department of Clinical Neurosciences and Neurological Research, 5th Floor Daly Wing, St Vincent s Hospital, 35 Victoria Parade, Fitzroy, Victoria 3065, Australia
J Clin Neurosci 18:290-2. 2011..without ragged red fibres was found in a 27-year-old male patient with a single unprovoked episode of severe rhabdomyolysis. There was no family history of neuromuscular disorder and sequencing revealed a novel COX III single base ..
- Rhabdomyolysis in the US Active Duty Army, 2004-2006Owen T Hill
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Med Sci Sports Exerc 44:442-9. 2012b>Rhabdomyolysis (RM) is a skeletal muscle disorder resulting in severe cellular injury caused by vigorous physical activity and other systemic etiologies...
- Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipientG V Ramesh Prasad
Division of Nephrology, Department of Medicine, St Michael s Hospital, University of Toronto, 61 Queen Street East, 9th Floor, Toronto, Ontario M5C 2T2 Canada
Transplantation 74:1200-1. 2002b>Rhabdomyolysis is a known complication of hepatic 3-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitor (statin) therapy for posttransplant hyperlipidemia, and thus monitoring for this effect is indicated...
- Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injuryKathryn Weibrecht
Division of Medical Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
J Med Toxicol 6:294-300. 2010b>Rhabdomyolysis is an uncommon finding in the emergency department. However, the clinical implications of rhabdomyolysis are important, with a significant minority of patients developing acute renal failure and multiorgan failure...
- Rhabdomyolysis: another complication after prolonged surgeryIgal Alterman
Department of General Intensive Care Unit, Edith Wolfson Medical Center, the Tel Aviv University Sackler School of Medicine, Holon 58100, Israel
J Clin Anesth 19:64-6. 2007..The patient's postoperative course was complicated by rhabdomyolysis manifested by elevated levels of serum creatine phosphokinase and the presence of myoglobin in urine and blood...
- Rhabdomyolysis a result of azithromycin and statins: an unrecognized interactionJohanna Strandell
The Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden
Br J Clin Pharmacol 68:427-34. 2009..Omega) highlighted azithromycin with the individual statins atorvastatin, lovastatin and simvastatin and rhabdomyolysis. The aim was to examine all reports including rhabdomyolysis-azithromycin and statins in VigiBase to assess if ..
- Statin-related adverse events: a meta-analysisMatthew A Silva
Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts 01608, USA
Clin Ther 28:26-35. 2006..The absolute frequencies of adverse events (AEs) between statins and placebo are very low in clinical trials, making clinical interpretation and application difficult...
- [Rhabdomyolysis and acute renal failure in human influenza A H1N1 mediated infection]Raúl Carrillo-Esper
Fundación Clínica Médica Sur, Mexico D F, Mexico
Gac Med Mex 145:519-21. 2009..This is the first report of a patient with radmoyolisis and acute renal failure secondary to A H1N1 influenza treated during the Mexico epidemic...
- Safety of statins: focus on clinical pharmacokinetics and drug interactionsStefano Bellosta
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Circulation 109:III50-7. 2004..This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions...
- The syndrome of rhabdomyolysis: complications and treatmentYiannis S Chatzizisis
AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece
Eur J Intern Med 19:568-74. 2008b>Rhabdomyolysis is a syndrome of skeletal muscle cell damage that leads to the release of toxic intracellular material into the systemic circulation...
- Rhabdomyolysis, renal failure, pericardial effusion, and acquired von Willebrand disease resulting from hypothyroidism in a 10-year-old girlAssimina Galli-Tsinopoulou
4th Department of Paediatrics, Medical School, Aristotle University of Thessaloniki, Greece
Thyroid 18:373-5. 2008..girl manifested unexplained muscle aches and high creatine phosphokinase (CPK) concentrations attributed to rhabdomyolysis in association with severe hypothyroidism due to autoimmune thyroiditis...
- Rhabdomyolysis in a patient with hypothyroidismGurcan Kisakol
Department of Internal Medicine, Division of Endocrinology, Meram Medical Faculty, Selcuk University, Konya 42080, Turkey
Endocr J 50:221-3. 2003We describe a case of rhabdomyolysis associating hypothyroidism. Hypothyroidism frequently leads to myalgias, muscle stiffness, cramps and sometimes elevated levels of muscle enzymes, but rhabdomyolysis is quite rare...
- Rhabdomyolysis in community acquired bacterial sepsis--a retrospective cohort studyAnita A Kumar
Department of General Medicine, Sri Ramachandra University, Tamilnadu, Chennai, India
PLoS ONE 4:e7182. 2009b>Rhabdomyolysis is often associated with sepsis and gram positive bacterial pathogens are reported to be the most frequent cause of sepsis induced rhabdomyolysis...
- Imatinib as a possible cause of severe rhabdomyolysisNicolas Penel
N Engl J Med 358:2746-7. 2008
- Acute rhabdomyolysis of the soleus muscle induced by a lightning strike: magnetic resonance and scintigraphic findingsNaofumi Watanabe
Department of Radiology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
Skeletal Radiol 36:671-5. 2007..In this article, we report a case of a 54-year-old man with acute rhabdomyolysis of the left soleus muscle associated with a lightning strike...
- Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian AmazonAndré M Siqueira
Tropical Medicine Foundation of Amazonas, Manaus, Amazonas, Brazil
Am J Trop Med Hyg 83:271-3. 2010Severe rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax...
- Unusual causes of rhabdomyolysisE E Mazokopakis
Division of Internal Medicine, Naval Hospital of Crete, Chania, Crete, Greece
Intern Med J 38:364-7. 2008We report four cases with unusual causes of rhabdomyolysis. These included quail ingestion (coturnism), interaction between grapefruit juice and atorvastatin, hypothyroidism and infection by Epstein-Barr virus.
- Statin-associated myopathyPaul D Thompson
Preventive Cardiology and Cardiovascular Research, Division of Cardiology, Hartford Hospital, Hartford, Conn 06102, USA
JAMA 289:1681-90. 2003..inhibitors) are associated with skeletal muscle complaints, including clinically important myositis and rhabdomyolysis, mild serum creatine kinase (CK) elevations, myalgia with and without elevated CK levels, muscle weakness, ..
- A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failureK P Moore
Joint Department of Medicine, Royal Free and University College Medical School, London NW3 2QG, United Kingdom
J Biol Chem 273:31731-7. 1998Muscle injury (rhabdomyolysis) and subsequent deposition of myoglobin in the kidney causes renal vasoconstriction and renal failure...
- Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr)David C Yao
Division of Genetics, Department of Neurology, Children s Hospital Boston, Dana Farber Cancer Institute and Harvard Medical School, MA 02115, USA
Blood 103:2401-3. 2004..anemia until splenectomy at age 3 and increasing muscle weakness, with death at age 4 associated with rhabdomyolysis and hyperkalemia...
- Peak value of blood myoglobin predicts acute renal failure induced by rhabdomyolysisShunji Kasaoka
Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi 755 8505, Japan
J Crit Care 25:601-4. 2010Acute renal failure (ARF) is the most important complication of rhabdomyolysis. Serial measurements of blood myoglobin might be useful for predicting rhabdomyolysis-induced ARF.
- Tsutsugamushi infection-associated acute rhabdomyolysis and acute renal failurePark Chi Young
Department of Internal Medicine, College of Medicine, Chosun University Kwangju, Korea
Korean J Intern Med 18:248-50. 2003b>Rhabdomyolysis is a rare complication that emerges in a variety of infectious diseases, such as tsutsugamushi infection...
- Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusionE Y Plotnikov
Laboratory of Mitochondrial Structure and Functions, AN Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, 119991 Russia
Biochim Biophys Acta 1812:77-86. 2011Oxidative stress-related renal pathologies apparently include rhabdomyolysis and ischemia/reperfusion phenomenon. These two pathologies were chosen for study in order to develop a proper strategy for protection of the kidney...
- Myopathy and rhabdomyolysis with lipid-lowering drugsChristian Hodel
HOVAT Pharma Consulting, Neubadstrasse 83, CH 4054 Basel, Switzerland
Toxicol Lett 128:159-68. 2002Drug-induced myopathy and rhabdomyolysis are rare adverse drug reactions (ADR). They have been seen after the introduction of modern lipid-lowering drugs more regularly...
- FDA adverse event reports on statin-associated rhabdomyolysisMohamed A Omar
Division of Pharmacy Practice and Administration, College of Pharmacy, University of Texas at Austin, Austin, TX, USA
Ann Pharmacother 36:288-95. 2002To determine the number of cases of statin-associated rhabdomyolysis reported to the Food and Drug Administration for 6 statins and to profile the cases.
- Rhabdomyolysis and acute renal failure in Plasmodium falciparum malariaFranck Reynaud
Nephrol Dial Transplant 20:847. 2005
- Melting muscles: novel H1N1 influenza A associated rhabdomyolysisDimple D'Silva
Department of Pediatric Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
Pediatr Infect Dis J 28:1138-9. 2009We report the first case of myositis and rhabdomyolysis after infection with novel influenza A (H1N1/09) virus. The case demonstrates the novel virus' capacity for causing significant disease...
- Statins and coronary artery bypass graft surgery: preoperative and postoperative efficacy and safetyAlexander Kulik
Vascular and Endovascular Surgery Fellow, Arizona Heart Institute, 2632 North 20th Street, Phoenix, Arizona, 85006, USA
Expert Opin Drug Saf 8:559-71. 2009..However, for patients undergoing coronary artery bypass graft surgery (CABG), statins appear to be underutilized, and concerns have been raised regarding their perioperative safety...
- Exclusion of linkage of the RYR1, CACNA1S, and ATP2A1 genes to recurrent exertional rhabdomyolysis in ThoroughbredsPatricia K Dranchak
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, 55108, USA
Am J Vet Res 67:1395-400. 2006To determine whether there was genetic linkage between the recurrent exertional rhabdomyolysis (RER) trait in Thoroughbred horse pedigrees and DNA markers in genes (the sarcoplasmic reticulum calcium release channel [RYR1] gene, the ..
- Rhabdomyolysis following laparoscopic gastric bypassD Filis
Bariatric Unit, Department of Surgical Oncology, Medical School, University of Crete, Heraklion, Crete, Greece
Obes Surg 15:1496-500. 2005b>Rhabdomyolysis is a rare complication of serious surgical procedures, and constitutes a clinical and biochemical syndrome, caused by injury and destruction of skeletal muscles...
- Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatinChristoph Schindler
Institute of Clinical Pharmacology, Faculty of Medicine, Technical University of Dresden, Dresden, Germany
Clin Ther 29:172-6. 2007..The patient was diagnosed with acute rhabdomyolysis; a score of 6 on the Naranjo adverse drug reaction probability scale indicated that pravastatin was the ..
- A rabbit model of peripheral compartment syndrome with associated rhabdomyolysis and a regenerative medicine approach for treatmentKerry A Daly
Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania 15219, USA
Tissue Eng Part C Methods 17:631-40. 2011..The present study provides a reproducible animal model with which to study PCS, and shows the potential of a regenerative medicine approach to PCS treatment...
- Drug induced rhabdomyolysisMartin Hohenegger
Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Wahringerstrasse 13A, A 1090 Vienna, Austria
Curr Opin Pharmacol 12:335-9. 2012b>Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins...
- Exertional rhabdomyolysis after influenza A (H3N2) infection in a basketball player boyE Sevketoglu
Department of Pediatrics, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey
Ann Trop Paediatr 31:93-6. 2011..Two days after completing the course, he resumed basketball and developed rhabdomyolysis associated with acute renal failure and disseminated intravascular coagulation...
- Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel alpha-1 Subunit Gene, and Calsequestrin-1 Gene PolymorphismsJohn F Capacchione
Assistant Professor, section sign Professor, Department of Anesthesiology, Department of Neurosurgery, National Naval Medical Center, Bethesda, Department of Surgery, Walter Reed Army Medical Center, Washington, D C
Anesthesiology 112:239-44. 2010
- Rhabdomyolysis following pandemic influenza A (H1N1) infectionShiuan Chih Chen
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
Neth J Med 68:317-9. 2010..Although pneumonia and acute respiratory distress syndrome are the most common severe complications of H1N1/09 infection, clinicians should be aware that H1N1/09 infection may be complicated by rhabdomyolysis.
- Rhabdomyolysis from an intramuscular injection of glyphosate-surfactant herbicideSheng Fu Weng
Department of Emergency, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
Clin Toxicol (Phila) 46:890-1. 2008..Most intoxicated cases are from ingestion, inhalation, and skin exposure. Intramuscular injection of GlySH has never been reported. We present a case of GlySH intoxication via intramuscular injection...
- [Difficult course of rhabdomyolysis in influenza A/H1N1]G Frohlich
Medizinische Klinik I, Dr Horst Schmidt Kliniken HSK Wiesbaden
Dtsch Med Wochenschr 138:2351-4. 2013..A 37-year-old man complained about a lack of strength, an unproductive cough and myalgia predominantly thigh-focused with subfebrile temperatures for days...
- The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trialsAlawi A Alsheikh-Ali
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Curr Atheroscler Rep 11:100-4. 2009..analyses have provided insight into the relationship between statin-induced reductions in LDL-C and risk of rhabdomyolysis, liver toxicity, and cancer...
- Pathophysiology and clinical presentations of rhabdomyolysisSandrine Guis
Rheumatology Department, Conception Hospital, 147, boulevard Baille, Marseille 13005, France
Joint Bone Spine 72:382-91. 2005b>Rhabdomyolysis has sparked new interest in recent years. The causes of rhabdomyolysis include drugs and other toxic agents, infections, physical exertion, crush injury, and muscle diseases (dystrophinopathies and metabolic myopathies)...
- Rhabdomyolysis and statin therapy: relevance to the elderlyDomenic A Sica
Department of Medicine, Section of Clinical Pharmacology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0160, USA
Am J Geriatr Cardiol 11:48-55. 2002..Its withdrawal was prompted by an unacceptably high rate of rhabdomyolysis associated with its use...
- Hypothyroidism-induced rhabdomyolysis and renal failureMohammad Reza Ardalan
Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran
Ren Fail 33:553-4. 2011Renal failure, due to rhabdomyolysis, is a rare complication of hypothyroidism. We report an elderly patient with primary hypothyroidism symptoms initially presented with inability to walk, leading to renal failure...
- Acute myocardial injury and rhabdomyolysis caused by multiple bee stingsANU MATHEW
Department of Medicine Unit 2, Christian Medical College and Hospital, Vellore 632 004, Tamil Nadu, India
J Assoc Physicians India 59:518-20. 2011..Acute myocardial ischemia due to bee envenomation is a rare event. We report the case of a 65 year old lady who presented with acute myocardial ischemia, severe rhabdomyolysis and angioedema following massive bee envenomation.
- Predictive factors for rhabdomyolysis after bariatric surgeryS Lagandré
Department of Anaesthesiology and Intensive Care, Huriez Hospital, University Hospital of Lille, France
Obes Surg 16:1365-70. 2006..Obesity is also incriminated in the development of postoperative rhabdomyolysis (RML). Its major risk is the development of renal failure which is associated with high mortality...
- Rhabdomyolysis causing AV blockade due to possible atorvastatin, esomeprazole, and clarithromycin interactionBrooke E Sipe
Pharmacy Department, Lutheran Hospital, Fort Wayne, IN 46804 4160, USA
Ann Pharmacother 37:808-11. 2003To report rhabdomyolysis (RML) causing third-degree atrioventricular block secondary to a possible interaction between atorvastatin, esomeprazole, and clarithromycin.
- Rhabdomyolysis and acute renal failure following minimally invasive spine surgery: report of 5 casesElias Dakwar
Department of Neurosurgery, University of South Florida, Tampa, Florida, USA
J Neurosurg Spine 14:785-8. 2011..b>Rhabdomyolysis (RM) is a rare but known complication of spine surgery, and acute renal failure (ARF) is in turn a potential ..
- Hypothyroidism as a cause of rhabdomyolysisMaría José Barahona
Department of Endocrinology and Nutrition, Hospital Sant Pau, 08025 Barcelona, Spain
Endocr J 49:621-3. 2002We describe a patient presenting with muscular symptoms and rhabdomyolysis without any other precipitating factor, except primary hypothyroidism...
- Rhabdomyolysis in early-onset very long-chain acyl-CoA dehydrogenase deficiency despite normal glucose after fastingH M Engbers
Metabolic Diseases, Wilhelmina Children s Hospital, Lundlaan 6, Utrecht 3508AB, The Netherlands
J Inherit Metab Dis 28:1151-2. 2005..deficiency presented in the neonatal period with hypoketotic hypoglycaemia and at the age of 1 year with rhabdomyolysis and normal glucose after fasting...
- Rhabdomyolysis after gastric bypass: severity and outcome patternsJoel Faintuch
Division of Gastrointestinal Surgery, Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil
Obes Surg 16:1209-13. 2006b>Rhabdomyolysis (RML) is a recently recognized complication of bariatric operations, but it is not known whether creatine kinase (CK) levels along with clinical markers are able to define the course and outcome.
- [Rhabdomyolysis induced by fenofibrate monotherapy]F Archambeaud-Mouveroux
Service de Médecine Interne B d Endocrinologie, Hopital du Cluzeau, 23, avenue Dominique Larrey, 87042 Limoges, France
Rev Med Interne 27:573-4. 2006b>Rhabdomyolysis with fibrate have been reported when fibrate are associated with statin or during renal insufficiency or hypothyroidism.
- [Renal failure secondary to effort rhabdomyolysis: report of three cases]Jorge Vega
Servicios Medicina Interna, Hospital Naval Almirante Nef, Vina del Mar, Chile
Rev Med Chil 134:211-6. 2006Renal failure secondary to effort rhabdomyolysis is uncommon. We report three males age 28, 37 (military sportsmen) and 44 years (sedentary obese), with this condition...
- Exertion-induced rhabdomyolysis in a patient on statin therapyDilip Unnikrishnan
Nephrol Dial Transplant 20:244. 2005
- Hemolytic uremic syndrome and rhabdomyolysis in a patient with succinate coenzyme Q reductase (complex II) deficiencyM V Micheletti
Pediatric Nephrology, Department of Pediatrics, University of Florence, Meyer Hospital, Florence, Italy
Clin Nephrol 76:68-73. 2011..b>Rhabdomyolysis is the dissolution of skeletal muscle due to various causes, including inborn errors of metabolism...
- Early fluid resuscitation in patients with rhabdomyolysisOri S Better
Department of Physiology and Biophysics, Faculty of Medicine Technion IIT, Rambam Hospital, Haifa 31096, Israel
Nat Rev Nephrol 7:416-22. 2011Extensive rhabdomyolysis is often lethal unless treated immediately. Early mortality arises from hypovolemic shock, hyperkalemia, acidosis and myoglobinuric acute kidney injury (AKI)...
- Rhabdomyolysis and acute renal failure resulting from alcohol and drug abuseC J Deighan
Renal Unit, Glasgow Royal Infirmary, Renal Unit, Western Infirmary, and Renal Unit, Stobhill Hospital, Glasgow, UK
QJM 93:29-33. 2000b>Rhabdomyolysis is a common cause of acute renal failure (ARF) associated with drug misuse. Abuse of the gel formulation of temazepam has been a particular problem in the West of Scotland...
- Human Heme Oxygenase-1 Gene Regulation in Renal InjuryAnupam Agarwal; Fiscal Year: 2012..kidney injury following ischemia-reperfusion, nephrotoxins, transplantation, acute glomerulonephritis and rhabdomyolysis as well as several non-renal settings of injury...
- Novel endonuclease-targeted approaches to nephroprotectionAlexei G Basnakian; Fiscal Year: 2013..is an excreting organ that is affected by many toxic chemicals metabolized in the body, including products of rhabdomyolysis (skeletal muscle degradation), which are known to induce acute renal injury (AKI) through the production of ..
- Genomics and pharmacodynamics of statin-related rhabdomyolysisBruce M Psaty; Fiscal Year: 2013..Baycol), an HMG-CoA reductase inhibitor (statin), was removed from the market because of an increased risk of rhabdomyolysis. In the original application, we conducted a case-control study of rhabdomyolysis to evaluate 3 ..
- CoEnzyme Q10 in Statin MyopathyPAUL DAVIS THOMPSON; Fiscal Year: 2010..myopathy with symptoms ranging from "mild" myalgia, muscle cramps and weakness to life-threatening rhabdomyolysis. Rhabdomyolysis is rare, but mild myopathic symptoms occur in approximately 10% of patients treated with high-..
- Basis of Muscle Dysfunction in Malignant Hyperthermia and Central Core DiseaseSusan L Hamilton; Fiscal Year: 2013..that has features of three of these disorders: malignant hyperthermia (MH) heat/exercise-induced exertional rhabdomyolysis (ER) and central core disease (CCD)...
- Noninvasive assessment of skeletal muscle integrity and function with statin useJill Slade; Fiscal Year: 2009..and pain are occasional side effects of statin use (1-7%) and in rare cases severe muscle destruction (rhabdomyolysis) may result...
- The Role of Statin Lactones in Statin ToxicityUwe Christians; Fiscal Year: 2006..P450/p-glycoprotein inhibitors significantly increases the risk to develop myopathy such as potentially fatal rhabdomyolysis. A recent example stressing the clinical importance of statin/fibrate drug interactions is the removal of ..
- REGULATION OF RYANODINE RECEPTOR BY NITROGEN OXIDESJerry Eu; Fiscal Year: 2003..Our results may lead to new insights into regulation of Ca2+ homeostasis in muscle and to the dysregulation of Ca2+ characteristic of disease states such as respiratory failure and rhabdomyolysis.
- Maternal Microchimerism in Renal DiseaseAnne Stevens; Fiscal Year: 2006..the expansion and differentiation of maternal cells in the kidney in two mouse models, renal ischemia and rhabdomyolysis. Chimeric maternal cells will be quantified and characterized before, during and after injury...
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICSRICHARD ZAGER; Fiscal Year: 2001....
- MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTIONChristie Ballantyne; Fiscal Year: 2002..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
- Obesity, Inflammation and Thrombosis: LOOK AHEADChristie M Ballantyne; Fiscal Year: 2010....
- The Role of Polycystins in the Regulation of Intracellular Calcium and Vascular RQi Qian; Fiscal Year: 2007..The information gained from the proposed study will greatly enhance our understanding in the pathogenesis of vascular complications in ADPKD and provide potential areas for therapeutic targets. [unreadable] [unreadable]..
- Molecular Characterization of Dantrolene Binding SiteJerome Parness; Fiscal Year: 2007..The information gained will provide insight into the molecular mechanism by which dantrolene interferes with intracellular Ca release and lead to rational drug design for the therapy of Ca sensitive muscle diseases. ..
- Dietary Macronutrients and Weight LossFrank Sacks; Fiscal Year: 2008..The results will be straightforwardly applicable to public health and clinical guidelines for obesity, and will increase our understanding of the biology of obesity and weight loss. ..
- A Pilot Study of Etanercept in DermatomyositisAnthony Amato; Fiscal Year: 2007..The information gained from this study is necessary in order to design larger therapeutic trials of etanercept and other agents in DM. ..
- Vascular Complications of Polycystic Kidney DiseaseQi Qian; Fiscal Year: 2007..This period of laboratory based study, plus the formalized career development program, is designed to train the candidate as a physician scientist with a unique expertise in vascular aspects of ADPKD. ..
- Phase I Clinical Trials of Anti-Cancer AgentsFrancis Giles; Fiscal Year: 2007..abstract_text> ..
- Hyperthermia: Uncoupling the agony from EcstasyJON SPRAGUE; Fiscal Year: 2007..thyrotoxic [unreadable] crisis). [unreadable] [unreadable] [unreadable]..
- fMRI Predictor Model for Stroke Locomotor RehabilitationBruce Dobkin; Fiscal Year: 2008..The study is a step toward using fMRI as a tool to develop theory- and evidencebased practices that lessen disabilities after stroke. [unreadable] [unreadable] [unreadable]..
- Genome-wide case-only study of antihypertensive drug-gene interactionsBruce M Psaty; Fiscal Year: 2010....
- The Effect of Statins on Skeletal Muscle FunctionPAUL DAVIS THOMPSON; Fiscal Year: 2010..trails, but are increasingly recognized to produce a skeletal muscle myopathy with symptoms ranging from rhabdomyolysis with renal failure to milder symptoms such as myalgia, cramps and weakness...
- THE CARNITINE TRANSPORTER IN HUMAN DISEASENicola Longo; Fiscal Year: 2010....
- Nonalcoholic steatohepatitis and Cytochrome P450 EnzymesNaga P Chalasani; Fiscal Year: 2010..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
- WGA Study to Identify Genetic Variants Associated with CV Events in CHSBruce Psaty; Fiscal Year: 2009..The proposed three-part study is efficient, has excellent power to detect small to modest-sized hazard ratios, provides a large sample of WG scans for aim 2, and includes an external replication. (End of Abstract) ..
- The Coronary Screening for Kidney Transplantation (COST) StudyBertram Kasiske; Fiscal Year: 2008..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
- Anaplerotic therapy in Propionic AcidemiaNicola Longo; Fiscal Year: 2008..This approach, if effective, could be extended to a number of other diseases, including other organic acidemias and mitochondrial disorders. [unreadable] [unreadable] [unreadable]..
- Prevalence and Treatment of Hypovitaminosis D in RAKaren Hansen; Fiscal Year: 2008..abstract_text> ..
- Physiogenomic Arrays for Clinical NeuropsychiatryGUALBERTO RUANO; Fiscal Year: 2006..The program will develop NeuroPsych Gene Array products as a new tool for systems understanding of neuropsychiatric and neurodegenerative diseases leading to early diagnosis and personalized therapy. [unreadable] [unreadable]..
- Diet Therapy of Long-Chain Fatty Acid Oxidation DefectsMELANIE GILLINGHAM; Fiscal Year: 2005..cardiomyopathy are largely prevented with this therapy, but chronic complications, such as exercise-induced rhabdomyolysis, are not prevented. MCT may provide an alternate fuel source during exercise...
- Apo A2, C1 and C2 and Diet in human apoB MetabolismFrank Sacks; Fiscal Year: 2005..abstract_text> ..
- POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANSMarc Andre Cornier; Fiscal Year: 2005..These studies will provide insight into the biology that predisposes to weight gain and regain and will lay the groundwork for future studies of the abnormalities in nutrient metabolism that exist in obese and preobese individuals. ..
- Brief Intervention to Reduce Alcohol Use in ED patientsWilliam Fernandez; Fiscal Year: 2004..e. routine care). ..
- ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTSBruce Psaty; Fiscal Year: 2004..58 (the difference between an odds ratio of 0.46 and 0.79 in subjects with and without the variant, respectively). Power for other primary aims is excellent; power for secondary aims is good to excellent. ..
- CLINICAL RESEARCH CURRICULUMBRIAN STROM; Fiscal Year: 2004..I. and co-PI s in the three distinct aspects of Clinical Research targeted by this program represent particular features of this proposal. ..
- FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITISJohn Reveille; Fiscal Year: 2003..abstract_text> ..
- MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISMBruce Psaty; Fiscal Year: 2001....
- Live Unrelated Kidney Donor & Sibling Follow-up StudyBertram Kasiske; Fiscal Year: 2005..Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD. ..
- Hormone Replacement Therapy and Prothrombotic VariantsBruce Psaty; Fiscal Year: 2005..Power for primary and secondary aims is excellent. Information from this project may help physicians counsel women about HRT to maximize either effectiveness, or safety, or both. ..
- AIDS-ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUMDavid Aboulafia; Fiscal Year: 2005..5. Assist the AMC and the NCI clinical trials cooperative groups and the NIAID ACTUs in the development and implementation of phase III studies if initial efforts of the AMC consortium are successful. ..
- Spondyloarthritis 2006; The Unmet NeedsJohn Reveille; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- VLDL and LDL Particle Types as CHD Risk FactorsFrank Sacks; Fiscal Year: 2006..abstract_text> ..
- Pharmacogenetics and Cardiovascular EventsBruce Psaty; Fiscal Year: 2006..The primary defense is replication: we would therefore welcome collaboration from others in the Pharmacogenetics Network in validation efforts. ..
- KINETICS OF HUMAN POSTPRANDIAL LIPOPROTEIN METABOLISMFrank Sacks; Fiscal Year: 2001..These studies will increase our understanding of the metabolic pathways that are activated or suppressed postprandially, and could lead to treatments for reducing the development of atherosclerosis. ..
- Ecstasy's neurotoxicity: role of hyperthermiaJON SPRAGUE; Fiscal Year: 2004....
- Intervention to Increase Safety Belt Use in ED PatientsWilliam Fernandez; Fiscal Year: 2005..e. the "teachable moment"). ..
- GERIATRIC CLINICAL EPIDEMIOLOGY TRAINING GRANTSTEVEN HALBERT; Fiscal Year: 2007..g., clinical trials, case control, cohort research, etc.), and the faculties' commitment to collaborative research. [unreadable] [unreadable]..
- Trends in and Outcomes of Medication Use in Older AdultsBruce Psaty; Fiscal Year: 2004..abstract_text> ..
- Utility of a New Database to Study Drug Safety during PregnancySOKO SETOGUCHI IWATA; Fiscal Year: 2008..This database based on large population-based follow-up data with linkable clinical birth data has the potential to enhance the safety of prescription drug use in pregnant women and their children. [unreadable] [unreadable] [unreadable]..
- Molecular determinants of exercise-induced muscle damageMonica Hubal; Fiscal Year: 2004..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
- Biological Markers of Recovery for the KidneyJohn A Kellum; Fiscal Year: 2010..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
- Coenzyme Q10 in Aging: A Planning GrantBeatrice Golomb; Fiscal Year: 2005..Thus there is strong conceptual as well as clinical rationale for assessing whether Q10 provides QOL & functional benefits in aging and whether it protects against untoward events associated with age. ..
- MOLECULAR STUDIES OF GENE TARGETED OLIGONUCLEOTIDESCY STEIN; Fiscal Year: 2002..Finally, in Specific Aim 3, we will amplify the delivery of alt-OMPs and chi-OMPs to cells by condensing them with a novel delivery agent, tetra (N-methylpyridyl) porphine. ..
- Mechanism of Action of G3139CY STEIN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Systems Engineering of Pheresis Intervention for SepsisJohn Kellum; Fiscal Year: 2009..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
- STATINS AND NON-CARDIAC ENDPOINTSBeatrice Golomb; Fiscal Year: 2003....
- Orthogonal Strategies for Specific Knockout ProductionCY STEIN; Fiscal Year: 2005..Finally, in Specific Aim 4, we will evaluate the molecular consequences of the down regulation of bcl-2 and bcl-xL by employing the 12,000 gene-containing Affymetrix oligonucleotide microarray technology. ..
- Characteristics and Costs of Impaired Fasting GlucoseGregory Nichols; Fiscal Year: 2005..Finally, we will calculate and compare the costs of medical care for patients in each FPG stage, and estimate multivariate models to identify factors that contribute to medical costs in each stage. ..