rhabdomyolysis

Summary

Summary: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Top Publications

  1. ncbi Risk factors for statin-associated rhabdomyolysis
    Stephanie Schech
    Center for Health Care Policy and Evaluation, Eden Prairie, MN 55344, USA
    Pharmacoepidemiol Drug Saf 16:352-8. 2007
  2. ncbi Rhabdomyolysis: a review of the literature
    F Y Khan
    Department of Medicine, Hamad General Hospital, Doha, Qatar
    Neth J Med 67:272-83. 2009
  3. doi Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic features
    Gianfranco Cervellin
    U O Pronto Soccorso e Medicina d Urgenza, Dipartimento di Emergenza Urgenza, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 48:749-56. 2010
  4. ncbi Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees
    M Davis
    Department of Neuropathology, Royal Perth Hospital, Western Australia
    Br J Anaesth 88:508-15. 2002
  5. ncbi The other medical causes of rhabdomyolysis
    Ronald C Allison
    Division of Pulmonary andCritical Care Medicine, Department of Internal Medicine, University of South Alabama College of Medicine, Medical Center, 2451 Fillingim Street, Suite 10 G, Mobile, AL 36617, USA
    Am J Med Sci 326:79-88. 2003
  6. pmc Cerivastatin, genetic variants, and the risk of rhabdomyolysis
    Kristin D Marciante
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Pharmacogenet Genomics 21:280-8. 2011
  7. ncbi Rhabdomyolysis: a review
    Jason D Warren
    Department of Neurology, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Muscle Nerve 25:332-47. 2002
  8. ncbi Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same?
    Marc Evans
    University Hospital of Wales, Heath Park, Cardiff, Wales
    Drug Saf 25:649-63. 2002
  9. doi Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review
    Karina Rodriguez-Capote
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Chem 55:2190-7. 2009
  10. doi Acute kidney injury due to rhabdomyolysis in H1N1 influenza infection
    Selman Unverdi
    Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey
    Ren Fail 33:450-1. 2011

Detail Information

Publications342 found, 100 shown here

  1. ncbi Risk factors for statin-associated rhabdomyolysis
    Stephanie Schech
    Center for Health Care Policy and Evaluation, Eden Prairie, MN 55344, USA
    Pharmacoepidemiol Drug Saf 16:352-8. 2007
    To identify and characterize risk factors for rhabdomyolysis in patients prescribed statin monotherapy or statin plus fibrate therapy.
  2. ncbi Rhabdomyolysis: a review of the literature
    F Y Khan
    Department of Medicine, Hamad General Hospital, Doha, Qatar
    Neth J Med 67:272-83. 2009
    b>Rhabdomyolysis is a potentially life-threatening syndrome that can develop from a variety of causes; the classic findings of muscular aches, weakness and tea-coloured urine are non-specific and may not always be present...
  3. doi Rhabdomyolysis: historical background, clinical, diagnostic and therapeutic features
    Gianfranco Cervellin
    U O Pronto Soccorso e Medicina d Urgenza, Dipartimento di Emergenza Urgenza, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Clin Chem Lab Med 48:749-56. 2010
    b>Rhabdomyolysis, a term used to describe the rapid breakdown of striated muscle, is characterized by rupture and necrosis of muscle fibers...
  4. ncbi Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees
    M Davis
    Department of Neuropathology, Royal Perth Hospital, Western Australia
    Br J Anaesth 88:508-15. 2002
    ..Two of these cases also show evidence of exercise-induced rhabdomyolysis. In each case MH susceptibility was confirmed by in vitro contracture testing of quadriceps muscle...
  5. ncbi The other medical causes of rhabdomyolysis
    Ronald C Allison
    Division of Pulmonary andCritical Care Medicine, Department of Internal Medicine, University of South Alabama College of Medicine, Medical Center, 2451 Fillingim Street, Suite 10 G, Mobile, AL 36617, USA
    Am J Med Sci 326:79-88. 2003
    b>Rhabdomyolysis is the clinical and laboratory syndrome resulting from skeletal muscle injury and release of potentially toxic substances into the circulation...
  6. pmc Cerivastatin, genetic variants, and the risk of rhabdomyolysis
    Kristin D Marciante
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Pharmacogenet Genomics 21:280-8. 2011
    The withdrawal of cerivastatin involved an uncommon but serious adverse reaction, rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of users, points to genetic factors as a potential cause...
  7. ncbi Rhabdomyolysis: a review
    Jason D Warren
    Department of Neurology, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Muscle Nerve 25:332-47. 2002
    b>Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements ..
  8. ncbi Effects of HMG-CoA reductase inhibitors on skeletal muscle: are all statins the same?
    Marc Evans
    University Hospital of Wales, Heath Park, Cardiff, Wales
    Drug Saf 25:649-63. 2002
    ..involving skeletal muscle being the most common, ranging from mild myopathy to myositis and occasionally to rhabdomyolysis and death...
  9. doi Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review
    Karina Rodriguez-Capote
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Chem 55:2190-7. 2009
    Urine myoglobin continues to be used as a marker of rhabdomyolysis, particularly to assess risk of developing acute renal failure and evaluate treatment success...
  10. doi Acute kidney injury due to rhabdomyolysis in H1N1 influenza infection
    Selman Unverdi
    Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey
    Ren Fail 33:450-1. 2011
    ..were documented for elevation of creatinine phosphokinase levels in the course of influenza infection, but rhabdomyolysis was rarely reported...
  11. ncbi Adverse effects of statins - mechanisms and consequences
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Curr Drug Saf 4:209-28. 2009
    ..Myopathy is the most frequent side effect of statins and in some cases may have a form of severe rhabdomyolysis. Less common adverse effects include hepatotoxicity, peripheral neuropathy, impaired myocardial contractility ..
  12. ncbi Rhabdomyolysis following dengue virus infection
    M Lim
    Department of Emergency Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Singapore Med J 46:645-6. 2005
    ..The patient was found to have raised serum creatine kinase levels, consistent with rhabdomyolysis. He was treated with intravenous hydration and recovered uneventfully...
  13. ncbi Rhabdomyolysis
    W H Bagley
    Department of Emergency Medicine, St Luke s Roosevelt Hospital, University Hospital of Columbia Physicians and Surgeons, New York, NY 10025, USA
    Intern Emerg Med 2:210-8. 2007
    b>Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle causing myoglobin and other intracellular proteins and electrolytes to leak into the circulation...
  14. ncbi Rhabdomyolysis associated with dengue virus infection
    Joshua S Davis
    Infectious Diseases Department, John Hunter Hospital, Newcastle, Australia
    Clin Infect Dis 38:e109-11. 2004
    We describe 2 patients who developed rhabdomyolysis due to dengue virus infection. The first patient recovered with no sequelae, but the second developed multiple organ failure and died...
  15. doi Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report
    Jianyong Wu
    Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hanghzou, 310003, Zhejiang, People s Republic of China
    Eur J Clin Pharmacol 65:1169-74. 2009
    Fibrates are used to manage mixed dyslipidemia. However, these drugs have the potential risk of inducing rhabdomyolysis. This paper gives an overview of the literature on rhabdomyolysis associated with fibrate therapy.
  16. ncbi Pathogenesis and treatment of renal dysfunction in rhabdomyolysis
    S G Holt
    Centre for Nephrology and Transplantation, Royal Free Hospital, Hampstead, London, UK
    Intensive Care Med 27:803-11. 2001
    b>Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction...
  17. ncbi Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California, USA
    J Trauma 56:1191-6. 2004
    ..of bicarbonate and mannitol (BIC/MAN) is commonly used to prevent renal failure (RF) in patients with rhabdomyolysis despite the absence of sufficient evidence validating its use...
  18. ncbi Etiology and frequency of rhabdomyolysis
    Corri Black
    Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, Massachusetts 02421, USA
    Pharmacotherapy 22:1524-6. 2002
    To describe the etiology and characteristics of patients with clinically diagnosed rhabdomyolysis in the United Kingdom General Practice Research Database (GPRD), and to estimate the risk of rhabdomyolysis in general and that associated ..
  19. doi Influenza B-associated rhabdomyolysis in Taiwanese children
    C T Wu
    Division of Pediatric Emergency Medicine, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tauyuan, Taiwan
    Acta Paediatr 99:1701-4. 2010
    Influenza B-associated rhabdomyolysis (IBAR) is an infrequent and little-known complication of influenza B virus infection in children...
  20. ncbi Serum creatine kinase as predictor of clinical course in rhabdomyolysis: a 5-year intensive care survey
    Arthur R de Meijer
    Department of Intensive Care, Meander Medical Centre, P O Box 1502, 3800 BM, Amersfoort, The Netherlands
    Intensive Care Med 29:1121-5. 2003
    To evaluate the risk factors for the development of acute renal failure (ARF) in severe rhabdomyolysis.
  21. ncbi Pressure-induced rhabdomyolysis after bariatric surgery
    Gonzalo Torres-Villalobos
    Department of Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Obes Surg 13:297-301. 2003
    ..Obesity has been reported as a risk factor for pressure-induced rhabdomyolysis, but no reports associated with bariatric surgery could be found in the literature...
  22. ncbi Elevated serum cardiac troponin I in rhabdomyolysis
    Gopikrishna Punukollu
    Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA
    Int J Cardiol 96:35-40. 2004
    To examine the etiology and clinical significance of elevated serum cardiac troponin I (cTnI) in patients with rhabdomyolysis.
  23. doi Acute encephalopathy and multi-organ involvement with rhabdomyolysis during primary HIV infection
    Miltiadis Douvoyiannis
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Children s Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Avenue, Rosenthal 4th Floor, Bronx, NY 10467, USA
    Int J Infect Dis 13:e299-304. 2009
    An adolescent male developed encephalopathy and multiple organ involvement with rhabdomyolysis during primary HIV infection (PHI). All symptoms and signs resolved within a few days...
  24. doi Serum myoglobin and renal morbidity and mortality following thoracic and thoraco-abdominal aortic repair: does rhabdomyolysis play a role?
    C C Miller
    Department of Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA
    Eur J Vasc Endovasc Surg 37:388-94. 2009
    ..We studied postoperative myoglobinaemia and renal dysfunction following aortic surgery...
  25. doi Acute kidney injury after coronary artery bypass grafting: does rhabdomyolysis play a role?
    Umberto Benedetto
    Cardiac Surgery Department, University of Rome La Sapienza, Policlinico S Andrea, Rome, Italy
    J Thorac Cardiovasc Surg 140:464-70. 2010
    In clinical situations in which rhabdomyolysis is common, renal dysfunction association with myoglobinemia is well described...
  26. pmc Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury
    Qingqing Wei
    Dept of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Renal Physiol 301:F162-70. 2011
    ..b>Rhabdomyolysis is another important clinical cause of AKI, due to the release of nephrotoxins (e.g...
  27. ncbi Outcomes in 45 patients with statin-associated myopathy
    Karen E Hansen
    Rheumatology Section, University of Wisconsin Medical School, H6 363 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Arch Intern Med 165:2671-6. 2005
    ..Furthermore, long-term outcomes and responses to statin rechallenge in patients with statin-associated myopathy are largely unknown...
  28. ncbi Prognostic value, kinetics and effect of CVVHDF on serum of the myoglobin and creatine kinase in critically ill patients with rhabdomyolysis
    T S Mikkelsen
    Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark
    Acta Anaesthesiol Scand 49:859-64. 2005
    I) To investigate the kinetics of the myoglobin and creatine kinase (CK) in rhabdomyolysis. Especially to describe those patients in whom an isolated increase in the myoglobin or the CK occurred at a later stage...
  29. ncbi Prevention of rhabdomyolysis in bariatric surgery
    João Eduardo Marques Tavares de Menezes Ettinger
    Bariatric Surgery Division, São Rafael Hospital, Salvador, Bahia, Brazil
    Obes Surg 15:874-9. 2005
    b>Rhabdomyolysis (RML) is a clinical and biochemical syndrome caused by skeletal muscle necrosis that results in extravasation of toxic intracellular contents from the myocytes into the circulatory system...
  30. ncbi A case of late onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting as recurrent rhabdomyolysis and acute renal failure
    Rumiko Izumi
    Department of Neurology, Tohoku University School of Medicine, Japan
    Intern Med 50:2663-8. 2011
    ..riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD) characterized by episodic recurrent rhabdomyolysis and acute renal failure after the age of 46...
  31. doi Use of RIFLE criteria to predict the severity and prognosis of acute kidney injury in emergency department patients with rhabdomyolysis
    Kathleen A Delaney
    University of Texas Southwestern Medical School, Parkland Memorial Hospital, Dallas, Texas 75930 8579, USA
    J Emerg Med 42:521-8. 2012
    RIFLE criteria (Risk, Injury, Failure, Loss, End-stage) have not been evaluated in Emergency Department (ED) patients at risk of acute kidney injury (AKI). AKI occurs in rhabdomyolysis.
  32. doi Incidence of hospitalized rhabdomyolysis with statin and fibrate use in an insured US population
    Kandace L Amend
    Epidemiology Division, OptumInsight, Ann Arbor, MI, USA
    Ann Pharmacother 45:1230-9. 2011
    The incidence of hospitalized rhabdomyolysis is not well characterized among patients taking statin-fibrate combination therapies.
  33. doi Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia
    Caroline Michot
    Paris Descartes University, INSERM U781 and Reference Center of Metabolic Diseases, Necker Hospital, Paris, France
    J Inherit Metab Dis 35:1119-28. 2012
    Recessive LPIN1 mutations were identified as a cause of severe rhabdomyolysis in pediatric patients. The human lipin family includes two other closely related members, lipin-2 and 3, which share strong homology and similar activity...
  34. ncbi Primary aldosteronism associated with severe rhabdomyolysis due to profound hypokalemia
    Atsushi Goto
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Tokyo
    Intern Med 48:219-23. 2009
    ..levels (15,760 IU/L), suggesting that the patient had hypokalemic paralysis and hypokalemia-induced rhabdomyolysis. Further evaluations, including adrenal venous sampling strongly suggested that he had primary aldosteronism...
  35. ncbi Toxicity of myoglobin and haemoglobin: oxidative stress in patients with rhabdomyolysis and subarachnoid haemorrhage
    B J Reeder
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biochem Soc Trans 30:745-8. 2002
    Haemolytic events, such as those following rhabdomyolysis and subarachnoid haemorrhage, often result in pathological complications such as vasoconstriction...
  36. doi Rhabdomyolysis: a review, with emphasis on the pediatric population
    Essam F Elsayed
    Department of Internal Medicine, Section of Nephrology, VA North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Pediatr Nephrol 25:7-18. 2010
    b>Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA...
  37. ncbi Rhabdomyolysis
    D Singh
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 27:39-48. 2005
    b>Rhabdomyolysis is a condition caused by skeletal muscle injury and release of muscle cell contents into the circulation...
  38. ncbi Laparoscopic renal surgery and the risk of rhabdomyolysis: diagnosis and treatment
    Karen E Reisiger
    Division of Urology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Urology 66:29-35. 2005
    Postoperative rhabdomyolysis is a rare but serious complication of laparoscopic renal urologic surgery...
  39. pmc Cocaine/heroin induced rhabdomyolysis and ventricular fibrillation
    B McCann
    Emergency Department, Royal Liverpool University Hospital, Liverpool, UK
    Emerg Med J 19:264-5. 2002
    ..The arrest is attributed primarily to hyperkalaemia/rhabdomyolysis-a recognised consequence of each of these drugs. The administration of naloxone may have been contributory...
  40. doi The relationship between exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia
    John F Capacchione
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Anesth Analg 109:1065-9. 2009
    Exertional heat illness, exertional rhabdomyolysis, and malignant hyperthermia (MH) are complex syndromes with similar pathophysiology...
  41. ncbi Cobalt protoporphyrin protects against hepatic parenchymal injury and microvascular dysfunction during experimental rhabdomyolysis
    Robert B Dorman
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Shock 23:275-80. 2005
    Although heme is necessary in many life-sustaining functions, its overwhelming systemic release with rhabdomyolysis (RM) is believed to be the cause of subsequent organ injury and dysfunction...
  42. doi Trabectedin-related rhabdomyolysis: an uncommon but fatal toxicity
    Aikaterini Stoyianni
    Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
    Tumori 97:252-5. 2011
    b>Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome...
  43. ncbi Exertional Rhabdomyolysis during a 246-km continuous running race
    Katerina P Skenderi
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Med Sci Sports Exerc 38:1054-7. 2006
    ..To evaluate the effect of continuous, moderate-intensity ultra-endurance running exercise on skeletal muscle and hepatic damage, as indicated by serum enzyme activity measured immediately following the race...
  44. doi Rhabdomyolysis in falciparum malaria--a series of twelve cases (five children and seven adults)
    Saroj K Mishra
    Department of Internal Medicine, Ispat General Hospital, Rourkela 769 005, Orissa, India
    Trop Doct 40:87-8. 2010
    There are very few reports in the literature of rhabdomyolysis in falciparum malaria and they mostly consist of single case studies. A report from Sri Lanka described a single patient with myoglobinuria and skeletal muscle necrosis...
  45. doi Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis and rhabdomyolysis
    Karkal Ravishankar Naik
    Department of Neurology, Jawaharlal Nehru Medical College and KLES Dr Prabhakar Kore Hospital and MRC, Nehrunagar, Belgaum, Karnataka 590010, India
    J Neurol Sci 291:5-11. 2010
    Neurological manifestations secondary to extrapontine myelinolysis and rhabdomyolysis caused by hypernatremia are infrequently reported...
  46. ncbi Evidence for susceptibility to malignant hyperthermia in patients with exercise-induced rhabdomyolysis
    F Wappler
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 94:95-100. 2001
    Malignant hyperthermia (MH), heat stroke, and exercise-induced rhabdomyolysis (ER) were suspected to be related syndromes. However, it is not known whether individuals with history of ER have an increased incidence of susceptibility to MH...
  47. doi Novel single base pair COX III subunit deletion of mitochondrial DNA associated with rhabdomyolysis
    Rosetta Marotta
    St Vincent s Melbourne Neuromuscular Diagnostic Laboratory, Department of Clinical Neurosciences and Neurological Research, 5th Floor Daly Wing, St Vincent s Hospital, 35 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Clin Neurosci 18:290-2. 2011
    ..without ragged red fibres was found in a 27-year-old male patient with a single unprovoked episode of severe rhabdomyolysis. There was no family history of neuromuscular disorder and sequencing revealed a novel COX III single base ..
  48. doi Rhabdomyolysis in the US Active Duty Army, 2004-2006
    Owen T Hill
    US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Med Sci Sports Exerc 44:442-9. 2012
    b>Rhabdomyolysis (RM) is a skeletal muscle disorder resulting in severe cellular injury caused by vigorous physical activity and other systemic etiologies...
  49. ncbi Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient
    G V Ramesh Prasad
    Division of Nephrology, Department of Medicine, St Michael s Hospital, University of Toronto, 61 Queen Street East, 9th Floor, Toronto, Ontario M5C 2T2 Canada
    Transplantation 74:1200-1. 2002
    b>Rhabdomyolysis is a known complication of hepatic 3-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitor (statin) therapy for posttransplant hyperlipidemia, and thus monitoring for this effect is indicated...
  50. pmc Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injury
    Kathryn Weibrecht
    Division of Medical Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, USA
    J Med Toxicol 6:294-300. 2010
    b>Rhabdomyolysis is an uncommon finding in the emergency department. However, the clinical implications of rhabdomyolysis are important, with a significant minority of patients developing acute renal failure and multiorgan failure...
  51. ncbi Rhabdomyolysis: another complication after prolonged surgery
    Igal Alterman
    Department of General Intensive Care Unit, Edith Wolfson Medical Center, the Tel Aviv University Sackler School of Medicine, Holon 58100, Israel
    J Clin Anesth 19:64-6. 2007
    ..The patient's postoperative course was complicated by rhabdomyolysis manifested by elevated levels of serum creatine phosphokinase and the presence of myoglobin in urine and blood...
  52. pmc Rhabdomyolysis a result of azithromycin and statins: an unrecognized interaction
    Johanna Strandell
    The Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden
    Br J Clin Pharmacol 68:427-34. 2009
    ..Omega) highlighted azithromycin with the individual statins atorvastatin, lovastatin and simvastatin and rhabdomyolysis. The aim was to examine all reports including rhabdomyolysis-azithromycin and statins in VigiBase to assess if ..
  53. ncbi Statin-related adverse events: a meta-analysis
    Matthew A Silva
    Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts 01608, USA
    Clin Ther 28:26-35. 2006
    ..The absolute frequencies of adverse events (AEs) between statins and placebo are very low in clinical trials, making clinical interpretation and application difficult...
  54. ncbi [Rhabdomyolysis and acute renal failure in human influenza A H1N1 mediated infection]
    Raúl Carrillo-Esper
    Fundación Clínica Médica Sur, Mexico D F, Mexico
    Gac Med Mex 145:519-21. 2009
    ..This is the first report of a patient with radmoyolisis and acute renal failure secondary to A H1N1 influenza treated during the Mexico epidemic...
  55. ncbi Safety of statins: focus on clinical pharmacokinetics and drug interactions
    Stefano Bellosta
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Circulation 109:III50-7. 2004
    ..This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions...
  56. doi The syndrome of rhabdomyolysis: complications and treatment
    Yiannis S Chatzizisis
    AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece
    Eur J Intern Med 19:568-74. 2008
    b>Rhabdomyolysis is a syndrome of skeletal muscle cell damage that leads to the release of toxic intracellular material into the systemic circulation...
  57. doi Rhabdomyolysis, renal failure, pericardial effusion, and acquired von Willebrand disease resulting from hypothyroidism in a 10-year-old girl
    Assimina Galli-Tsinopoulou
    4th Department of Paediatrics, Medical School, Aristotle University of Thessaloniki, Greece
    Thyroid 18:373-5. 2008
    ..girl manifested unexplained muscle aches and high creatine phosphokinase (CPK) concentrations attributed to rhabdomyolysis in association with severe hypothyroidism due to autoimmune thyroiditis...
  58. ncbi Rhabdomyolysis in a patient with hypothyroidism
    Gurcan Kisakol
    Department of Internal Medicine, Division of Endocrinology, Meram Medical Faculty, Selcuk University, Konya 42080, Turkey
    Endocr J 50:221-3. 2003
    We describe a case of rhabdomyolysis associating hypothyroidism. Hypothyroidism frequently leads to myalgias, muscle stiffness, cramps and sometimes elevated levels of muscle enzymes, but rhabdomyolysis is quite rare...
  59. pmc Rhabdomyolysis in community acquired bacterial sepsis--a retrospective cohort study
    Anita A Kumar
    Department of General Medicine, Sri Ramachandra University, Tamilnadu, Chennai, India
    PLoS ONE 4:e7182. 2009
    b>Rhabdomyolysis is often associated with sepsis and gram positive bacterial pathogens are reported to be the most frequent cause of sepsis induced rhabdomyolysis...
  60. doi Imatinib as a possible cause of severe rhabdomyolysis
    Nicolas Penel
    N Engl J Med 358:2746-7. 2008
  61. ncbi Acute rhabdomyolysis of the soleus muscle induced by a lightning strike: magnetic resonance and scintigraphic findings
    Naofumi Watanabe
    Department of Radiology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Skeletal Radiol 36:671-5. 2007
    ..In this article, we report a case of a 54-year-old man with acute rhabdomyolysis of the left soleus muscle associated with a lightning strike...
  62. pmc Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon
    André M Siqueira
    Tropical Medicine Foundation of Amazonas, Manaus, Amazonas, Brazil
    Am J Trop Med Hyg 83:271-3. 2010
    Severe rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax...
  63. doi Unusual causes of rhabdomyolysis
    E E Mazokopakis
    Division of Internal Medicine, Naval Hospital of Crete, Chania, Crete, Greece
    Intern Med J 38:364-7. 2008
    We report four cases with unusual causes of rhabdomyolysis. These included quail ingestion (coturnism), interaction between grapefruit juice and atorvastatin, hypothyroidism and infection by Epstein-Barr virus.
  64. ncbi Statin-associated myopathy
    Paul D Thompson
    Preventive Cardiology and Cardiovascular Research, Division of Cardiology, Hartford Hospital, Hartford, Conn 06102, USA
    JAMA 289:1681-90. 2003
    ..inhibitors) are associated with skeletal muscle complaints, including clinically important myositis and rhabdomyolysis, mild serum creatine kinase (CK) elevations, myalgia with and without elevated CK levels, muscle weakness, ..
  65. ncbi A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure
    K P Moore
    Joint Department of Medicine, Royal Free and University College Medical School, London NW3 2QG, United Kingdom
    J Biol Chem 273:31731-7. 1998
    Muscle injury (rhabdomyolysis) and subsequent deposition of myoglobin in the kidney causes renal vasoconstriction and renal failure...
  66. ncbi Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr)
    David C Yao
    Division of Genetics, Department of Neurology, Children s Hospital Boston, Dana Farber Cancer Institute and Harvard Medical School, MA 02115, USA
    Blood 103:2401-3. 2004
    ..anemia until splenectomy at age 3 and increasing muscle weakness, with death at age 4 associated with rhabdomyolysis and hyperkalemia...
  67. doi Peak value of blood myoglobin predicts acute renal failure induced by rhabdomyolysis
    Shunji Kasaoka
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Yamaguchi 755 8505, Japan
    J Crit Care 25:601-4. 2010
    Acute renal failure (ARF) is the most important complication of rhabdomyolysis. Serial measurements of blood myoglobin might be useful for predicting rhabdomyolysis-induced ARF.
  68. ncbi Tsutsugamushi infection-associated acute rhabdomyolysis and acute renal failure
    Park Chi Young
    Department of Internal Medicine, College of Medicine, Chosun University Kwangju, Korea
    Korean J Intern Med 18:248-50. 2003
    b>Rhabdomyolysis is a rare complication that emerges in a variety of infectious diseases, such as tsutsugamushi infection...
  69. doi Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion
    E Y Plotnikov
    Laboratory of Mitochondrial Structure and Functions, AN Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, 119991 Russia
    Biochim Biophys Acta 1812:77-86. 2011
    Oxidative stress-related renal pathologies apparently include rhabdomyolysis and ischemia/reperfusion phenomenon. These two pathologies were chosen for study in order to develop a proper strategy for protection of the kidney...
  70. ncbi Myopathy and rhabdomyolysis with lipid-lowering drugs
    Christian Hodel
    HOVAT Pharma Consulting, Neubadstrasse 83, CH 4054 Basel, Switzerland
    Toxicol Lett 128:159-68. 2002
    Drug-induced myopathy and rhabdomyolysis are rare adverse drug reactions (ADR). They have been seen after the introduction of modern lipid-lowering drugs more regularly...
  71. ncbi FDA adverse event reports on statin-associated rhabdomyolysis
    Mohamed A Omar
    Division of Pharmacy Practice and Administration, College of Pharmacy, University of Texas at Austin, Austin, TX, USA
    Ann Pharmacother 36:288-95. 2002
    To determine the number of cases of statin-associated rhabdomyolysis reported to the Food and Drug Administration for 6 statins and to profile the cases.
  72. ncbi Rhabdomyolysis and acute renal failure in Plasmodium falciparum malaria
    Franck Reynaud
    Nephrol Dial Transplant 20:847. 2005
  73. doi Melting muscles: novel H1N1 influenza A associated rhabdomyolysis
    Dimple D'Silva
    Department of Pediatric Infectious Diseases, Monash Medical Centre, Clayton, Victoria, Australia
    Pediatr Infect Dis J 28:1138-9. 2009
    We report the first case of myositis and rhabdomyolysis after infection with novel influenza A (H1N1/09) virus. The case demonstrates the novel virus' capacity for causing significant disease...
  74. doi Statins and coronary artery bypass graft surgery: preoperative and postoperative efficacy and safety
    Alexander Kulik
    Vascular and Endovascular Surgery Fellow, Arizona Heart Institute, 2632 North 20th Street, Phoenix, Arizona, 85006, USA
    Expert Opin Drug Saf 8:559-71. 2009
    ..However, for patients undergoing coronary artery bypass graft surgery (CABG), statins appear to be underutilized, and concerns have been raised regarding their perioperative safety...
  75. ncbi Exclusion of linkage of the RYR1, CACNA1S, and ATP2A1 genes to recurrent exertional rhabdomyolysis in Thoroughbreds
    Patricia K Dranchak
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, 55108, USA
    Am J Vet Res 67:1395-400. 2006
    To determine whether there was genetic linkage between the recurrent exertional rhabdomyolysis (RER) trait in Thoroughbred horse pedigrees and DNA markers in genes (the sarcoplasmic reticulum calcium release channel [RYR1] gene, the ..
  76. ncbi Rhabdomyolysis following laparoscopic gastric bypass
    D Filis
    Bariatric Unit, Department of Surgical Oncology, Medical School, University of Crete, Heraklion, Crete, Greece
    Obes Surg 15:1496-500. 2005
    b>Rhabdomyolysis is a rare complication of serious surgical procedures, and constitutes a clinical and biochemical syndrome, caused by injury and destruction of skeletal muscles...
  77. ncbi Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin
    Christoph Schindler
    Institute of Clinical Pharmacology, Faculty of Medicine, Technical University of Dresden, Dresden, Germany
    Clin Ther 29:172-6. 2007
    ..The patient was diagnosed with acute rhabdomyolysis; a score of 6 on the Naranjo adverse drug reaction probability scale indicated that pravastatin was the ..
  78. doi A rabbit model of peripheral compartment syndrome with associated rhabdomyolysis and a regenerative medicine approach for treatment
    Kerry A Daly
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part C Methods 17:631-40. 2011
    ..The present study provides a reproducible animal model with which to study PCS, and shows the potential of a regenerative medicine approach to PCS treatment...
  79. pmc Drug induced rhabdomyolysis
    Martin Hohenegger
    Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Wahringerstrasse 13A, A 1090 Vienna, Austria
    Curr Opin Pharmacol 12:335-9. 2012
    b>Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins...
  80. doi Exertional rhabdomyolysis after influenza A (H3N2) infection in a basketball player boy
    E Sevketoglu
    Department of Pediatrics, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey
    Ann Trop Paediatr 31:93-6. 2011
    ..Two days after completing the course, he resumed basketball and developed rhabdomyolysis associated with acute renal failure and disseminated intravascular coagulation...
  81. ncbi Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel alpha-1 Subunit Gene, and Calsequestrin-1 Gene Polymorphisms
    John F Capacchione
    Assistant Professor, section sign Professor, Department of Anesthesiology, Department of Neurosurgery, National Naval Medical Center, Bethesda, Department of Surgery, Walter Reed Army Medical Center, Washington, D C
    Anesthesiology 112:239-44. 2010
  82. ncbi Rhabdomyolysis following pandemic influenza A (H1N1) infection
    Shiuan Chih Chen
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Neth J Med 68:317-9. 2010
    ..Although pneumonia and acute respiratory distress syndrome are the most common severe complications of H1N1/09 infection, clinicians should be aware that H1N1/09 infection may be complicated by rhabdomyolysis.
  83. doi Rhabdomyolysis from an intramuscular injection of glyphosate-surfactant herbicide
    Sheng Fu Weng
    Department of Emergency, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Clin Toxicol (Phila) 46:890-1. 2008
    ..Most intoxicated cases are from ingestion, inhalation, and skin exposure. Intramuscular injection of GlySH has never been reported. We present a case of GlySH intoxication via intramuscular injection...
  84. doi [Difficult course of rhabdomyolysis in influenza A/H1N1]
    G Frohlich
    Medizinische Klinik I, Dr Horst Schmidt Kliniken HSK Wiesbaden
    Dtsch Med Wochenschr 138:2351-4. 2013
    ..A 37-year-old man complained about a lack of strength, an unproductive cough and myalgia predominantly thigh-focused with subfebrile temperatures for days...
  85. ncbi The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 11:100-4. 2009
    ..analyses have provided insight into the relationship between statin-induced reductions in LDL-C and risk of rhabdomyolysis, liver toxicity, and cancer...
  86. ncbi Pathophysiology and clinical presentations of rhabdomyolysis
    Sandrine Guis
    Rheumatology Department, Conception Hospital, 147, boulevard Baille, Marseille 13005, France
    Joint Bone Spine 72:382-91. 2005
    b>Rhabdomyolysis has sparked new interest in recent years. The causes of rhabdomyolysis include drugs and other toxic agents, infections, physical exertion, crush injury, and muscle diseases (dystrophinopathies and metabolic myopathies)...
  87. ncbi Rhabdomyolysis and statin therapy: relevance to the elderly
    Domenic A Sica
    Department of Medicine, Section of Clinical Pharmacology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0160, USA
    Am J Geriatr Cardiol 11:48-55. 2002
    ..Its withdrawal was prompted by an unacceptably high rate of rhabdomyolysis associated with its use...
  88. doi Hypothyroidism-induced rhabdomyolysis and renal failure
    Mohammad Reza Ardalan
    Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran
    Ren Fail 33:553-4. 2011
    Renal failure, due to rhabdomyolysis, is a rare complication of hypothyroidism. We report an elderly patient with primary hypothyroidism symptoms initially presented with inability to walk, leading to renal failure...
  89. ncbi Acute myocardial injury and rhabdomyolysis caused by multiple bee stings
    ANU MATHEW
    Department of Medicine Unit 2, Christian Medical College and Hospital, Vellore 632 004, Tamil Nadu, India
    J Assoc Physicians India 59:518-20. 2011
    ..Acute myocardial ischemia due to bee envenomation is a rare event. We report the case of a 65 year old lady who presented with acute myocardial ischemia, severe rhabdomyolysis and angioedema following massive bee envenomation.
  90. ncbi Predictive factors for rhabdomyolysis after bariatric surgery
    S Lagandré
    Department of Anaesthesiology and Intensive Care, Huriez Hospital, University Hospital of Lille, France
    Obes Surg 16:1365-70. 2006
    ..Obesity is also incriminated in the development of postoperative rhabdomyolysis (RML). Its major risk is the development of renal failure which is associated with high mortality...
  91. ncbi Rhabdomyolysis causing AV blockade due to possible atorvastatin, esomeprazole, and clarithromycin interaction
    Brooke E Sipe
    Pharmacy Department, Lutheran Hospital, Fort Wayne, IN 46804 4160, USA
    Ann Pharmacother 37:808-11. 2003
    To report rhabdomyolysis (RML) causing third-degree atrioventricular block secondary to a possible interaction between atorvastatin, esomeprazole, and clarithromycin.
  92. doi Rhabdomyolysis and acute renal failure following minimally invasive spine surgery: report of 5 cases
    Elias Dakwar
    Department of Neurosurgery, University of South Florida, Tampa, Florida, USA
    J Neurosurg Spine 14:785-8. 2011
    ..b>Rhabdomyolysis (RM) is a rare but known complication of spine surgery, and acute renal failure (ARF) is in turn a potential ..
  93. ncbi Hypothyroidism as a cause of rhabdomyolysis
    María José Barahona
    Department of Endocrinology and Nutrition, Hospital Sant Pau, 08025 Barcelona, Spain
    Endocr J 49:621-3. 2002
    We describe a patient presenting with muscular symptoms and rhabdomyolysis without any other precipitating factor, except primary hypothyroidism...
  94. ncbi Rhabdomyolysis in early-onset very long-chain acyl-CoA dehydrogenase deficiency despite normal glucose after fasting
    H M Engbers
    Metabolic Diseases, Wilhelmina Children s Hospital, Lundlaan 6, Utrecht 3508AB, The Netherlands
    J Inherit Metab Dis 28:1151-2. 2005
    ..deficiency presented in the neonatal period with hypoketotic hypoglycaemia and at the age of 1 year with rhabdomyolysis and normal glucose after fasting...
  95. ncbi Rhabdomyolysis after gastric bypass: severity and outcome patterns
    Joel Faintuch
    Division of Gastrointestinal Surgery, Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil
    Obes Surg 16:1209-13. 2006
    b>Rhabdomyolysis (RML) is a recently recognized complication of bariatric operations, but it is not known whether creatine kinase (CK) levels along with clinical markers are able to define the course and outcome.
  96. ncbi [Rhabdomyolysis induced by fenofibrate monotherapy]
    F Archambeaud-Mouveroux
    Service de Médecine Interne B d Endocrinologie, Hopital du Cluzeau, 23, avenue Dominique Larrey, 87042 Limoges, France
    Rev Med Interne 27:573-4. 2006
    b>Rhabdomyolysis with fibrate have been reported when fibrate are associated with statin or during renal insufficiency or hypothyroidism.
  97. ncbi [Renal failure secondary to effort rhabdomyolysis: report of three cases]
    Jorge Vega
    Servicios Medicina Interna, Hospital Naval Almirante Nef, Vina del Mar, Chile
    Rev Med Chil 134:211-6. 2006
    Renal failure secondary to effort rhabdomyolysis is uncommon. We report three males age 28, 37 (military sportsmen) and 44 years (sedentary obese), with this condition...
  98. ncbi Exertion-induced rhabdomyolysis in a patient on statin therapy
    Dilip Unnikrishnan
    Nephrol Dial Transplant 20:244. 2005
  99. ncbi Hemolytic uremic syndrome and rhabdomyolysis in a patient with succinate coenzyme Q reductase (complex II) deficiency
    M V Micheletti
    Pediatric Nephrology, Department of Pediatrics, University of Florence, Meyer Hospital, Florence, Italy
    Clin Nephrol 76:68-73. 2011
    ..b>Rhabdomyolysis is the dissolution of skeletal muscle due to various causes, including inborn errors of metabolism...
  100. doi Early fluid resuscitation in patients with rhabdomyolysis
    Ori S Better
    Department of Physiology and Biophysics, Faculty of Medicine Technion IIT, Rambam Hospital, Haifa 31096, Israel
    Nat Rev Nephrol 7:416-22. 2011
    Extensive rhabdomyolysis is often lethal unless treated immediately. Early mortality arises from hypovolemic shock, hyperkalemia, acidosis and myoglobinuric acute kidney injury (AKI)...
  101. ncbi Rhabdomyolysis and acute renal failure resulting from alcohol and drug abuse
    C J Deighan
    Renal Unit, Glasgow Royal Infirmary, Renal Unit, Western Infirmary, and Renal Unit, Stobhill Hospital, Glasgow, UK
    QJM 93:29-33. 2000
    b>Rhabdomyolysis is a common cause of acute renal failure (ARF) associated with drug misuse. Abuse of the gel formulation of temazepam has been a particular problem in the West of Scotland...

Research Grants61

  1. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..kidney injury following ischemia-reperfusion, nephrotoxins, transplantation, acute glomerulonephritis and rhabdomyolysis as well as several non-renal settings of injury...
  2. Novel endonuclease-targeted approaches to nephroprotection
    Alexei G Basnakian; Fiscal Year: 2013
    ..is an excreting organ that is affected by many toxic chemicals metabolized in the body, including products of rhabdomyolysis (skeletal muscle degradation), which are known to induce acute renal injury (AKI) through the production of ..
  3. Genomics and pharmacodynamics of statin-related rhabdomyolysis
    Bruce M Psaty; Fiscal Year: 2013
    ..Baycol), an HMG-CoA reductase inhibitor (statin), was removed from the market because of an increased risk of rhabdomyolysis. In the original application, we conducted a case-control study of rhabdomyolysis to evaluate 3 ..
  4. CoEnzyme Q10 in Statin Myopathy
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ..myopathy with symptoms ranging from "mild" myalgia, muscle cramps and weakness to life-threatening rhabdomyolysis. Rhabdomyolysis is rare, but mild myopathic symptoms occur in approximately 10% of patients treated with high-..
  5. Basis of Muscle Dysfunction in Malignant Hyperthermia and Central Core Disease
    Susan L Hamilton; Fiscal Year: 2013
    ..that has features of three of these disorders: malignant hyperthermia (MH) heat/exercise-induced exertional rhabdomyolysis (ER) and central core disease (CCD)...
  6. Noninvasive assessment of skeletal muscle integrity and function with statin use
    Jill Slade; Fiscal Year: 2009
    ..and pain are occasional side effects of statin use (1-7%) and in rare cases severe muscle destruction (rhabdomyolysis) may result...
  7. The Role of Statin Lactones in Statin Toxicity
    Uwe Christians; Fiscal Year: 2006
    ..P450/p-glycoprotein inhibitors significantly increases the risk to develop myopathy such as potentially fatal rhabdomyolysis. A recent example stressing the clinical importance of statin/fibrate drug interactions is the removal of ..
  8. REGULATION OF RYANODINE RECEPTOR BY NITROGEN OXIDES
    Jerry Eu; Fiscal Year: 2003
    ..Our results may lead to new insights into regulation of Ca2+ homeostasis in muscle and to the dysregulation of Ca2+ characteristic of disease states such as respiratory failure and rhabdomyolysis.
  9. Maternal Microchimerism in Renal Disease
    Anne Stevens; Fiscal Year: 2006
    ..the expansion and differentiation of maternal cells in the kidney in two mouse models, renal ischemia and rhabdomyolysis. Chimeric maternal cells will be quantified and characterized before, during and after injury...
  10. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  11. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  12. MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTION
    Christie Ballantyne; Fiscal Year: 2002
    ..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
  13. Obesity, Inflammation and Thrombosis: LOOK AHEAD
    Christie M Ballantyne; Fiscal Year: 2010
    ....
  14. The Role of Polycystins in the Regulation of Intracellular Calcium and Vascular R
    Qi Qian; Fiscal Year: 2007
    ..The information gained from the proposed study will greatly enhance our understanding in the pathogenesis of vascular complications in ADPKD and provide potential areas for therapeutic targets. [unreadable] [unreadable]..
  15. Molecular Characterization of Dantrolene Binding Site
    Jerome Parness; Fiscal Year: 2007
    ..The information gained will provide insight into the molecular mechanism by which dantrolene interferes with intracellular Ca release and lead to rational drug design for the therapy of Ca sensitive muscle diseases. ..
  16. Dietary Macronutrients and Weight Loss
    Frank Sacks; Fiscal Year: 2008
    ..The results will be straightforwardly applicable to public health and clinical guidelines for obesity, and will increase our understanding of the biology of obesity and weight loss. ..
  17. A Pilot Study of Etanercept in Dermatomyositis
    Anthony Amato; Fiscal Year: 2007
    ..The information gained from this study is necessary in order to design larger therapeutic trials of etanercept and other agents in DM. ..
  18. Vascular Complications of Polycystic Kidney Disease
    Qi Qian; Fiscal Year: 2007
    ..This period of laboratory based study, plus the formalized career development program, is designed to train the candidate as a physician scientist with a unique expertise in vascular aspects of ADPKD. ..
  19. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  20. Hyperthermia: Uncoupling the agony from Ecstasy
    JON SPRAGUE; Fiscal Year: 2007
    ..thyrotoxic [unreadable] crisis). [unreadable] [unreadable] [unreadable]..
  21. fMRI Predictor Model for Stroke Locomotor Rehabilitation
    Bruce Dobkin; Fiscal Year: 2008
    ..The study is a step toward using fMRI as a tool to develop theory- and evidencebased practices that lessen disabilities after stroke. [unreadable] [unreadable] [unreadable]..
  22. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce M Psaty; Fiscal Year: 2010
    ....
  23. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ..trails, but are increasingly recognized to produce a skeletal muscle myopathy with symptoms ranging from rhabdomyolysis with renal failure to milder symptoms such as myalgia, cramps and weakness...
  24. THE CARNITINE TRANSPORTER IN HUMAN DISEASE
    Nicola Longo; Fiscal Year: 2010
    ....
  25. Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
    Naga P Chalasani; Fiscal Year: 2010
    ..Additionally, we examine the relationship between this enzyme activity and the degree of insulin resistance and lipid peroxidation. ..
  26. WGA Study to Identify Genetic Variants Associated with CV Events in CHS
    Bruce Psaty; Fiscal Year: 2009
    ..The proposed three-part study is efficient, has excellent power to detect small to modest-sized hazard ratios, provides a large sample of WG scans for aim 2, and includes an external replication. (End of Abstract) ..
  27. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2008
    ..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
  28. Anaplerotic therapy in Propionic Acidemia
    Nicola Longo; Fiscal Year: 2008
    ..This approach, if effective, could be extended to a number of other diseases, including other organic acidemias and mitochondrial disorders. [unreadable] [unreadable] [unreadable]..
  29. Prevalence and Treatment of Hypovitaminosis D in RA
    Karen Hansen; Fiscal Year: 2008
    ..abstract_text> ..
  30. Physiogenomic Arrays for Clinical Neuropsychiatry
    GUALBERTO RUANO; Fiscal Year: 2006
    ..The program will develop NeuroPsych Gene Array products as a new tool for systems understanding of neuropsychiatric and neurodegenerative diseases leading to early diagnosis and personalized therapy. [unreadable] [unreadable]..
  31. Diet Therapy of Long-Chain Fatty Acid Oxidation Defects
    MELANIE GILLINGHAM; Fiscal Year: 2005
    ..cardiomyopathy are largely prevented with this therapy, but chronic complications, such as exercise-induced rhabdomyolysis, are not prevented. MCT may provide an alternate fuel source during exercise...
  32. Apo A2, C1 and C2 and Diet in human apoB Metabolism
    Frank Sacks; Fiscal Year: 2005
    ..abstract_text> ..
  33. POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANS
    Marc Andre Cornier; Fiscal Year: 2005
    ..These studies will provide insight into the biology that predisposes to weight gain and regain and will lay the groundwork for future studies of the abnormalities in nutrient metabolism that exist in obese and preobese individuals. ..
  34. Brief Intervention to Reduce Alcohol Use in ED patients
    William Fernandez; Fiscal Year: 2004
    ..e. routine care). ..
  35. ANTIHYPERTENSIVE DRUG/GENE INTERACTIONS AND CV EVENTS
    Bruce Psaty; Fiscal Year: 2004
    ..58 (the difference between an odds ratio of 0.46 and 0.79 in subjects with and without the variant, respectively). Power for other primary aims is excellent; power for secondary aims is good to excellent. ..
  36. CLINICAL RESEARCH CURRICULUM
    BRIAN STROM; Fiscal Year: 2004
    ..I. and co-PI s in the three distinct aspects of Clinical Research targeted by this program represent particular features of this proposal. ..
  37. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..abstract_text> ..
  38. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ....
  39. Live Unrelated Kidney Donor & Sibling Follow-up Study
    Bertram Kasiske; Fiscal Year: 2005
    ..Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD. ..
  40. Hormone Replacement Therapy and Prothrombotic Variants
    Bruce Psaty; Fiscal Year: 2005
    ..Power for primary and secondary aims is excellent. Information from this project may help physicians counsel women about HRT to maximize either effectiveness, or safety, or both. ..
  41. AIDS-ASSOCIATED MALIGNANCIES CLINICAL TRIALS CONSORTIUM
    David Aboulafia; Fiscal Year: 2005
    ..5. Assist the AMC and the NCI clinical trials cooperative groups and the NIAID ACTUs in the development and implementation of phase III studies if initial efforts of the AMC consortium are successful. ..
  42. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  43. VLDL and LDL Particle Types as CHD Risk Factors
    Frank Sacks; Fiscal Year: 2006
    ..abstract_text> ..
  44. Pharmacogenetics and Cardiovascular Events
    Bruce Psaty; Fiscal Year: 2006
    ..The primary defense is replication: we would therefore welcome collaboration from others in the Pharmacogenetics Network in validation efforts. ..
  45. KINETICS OF HUMAN POSTPRANDIAL LIPOPROTEIN METABOLISM
    Frank Sacks; Fiscal Year: 2001
    ..These studies will increase our understanding of the metabolic pathways that are activated or suppressed postprandially, and could lead to treatments for reducing the development of atherosclerosis. ..
  46. Ecstasy's neurotoxicity: role of hyperthermia
    JON SPRAGUE; Fiscal Year: 2004
    ....
  47. Intervention to Increase Safety Belt Use in ED Patients
    William Fernandez; Fiscal Year: 2005
    ..e. the "teachable moment"). ..
  48. GERIATRIC CLINICAL EPIDEMIOLOGY TRAINING GRANT
    STEVEN HALBERT; Fiscal Year: 2007
    ..g., clinical trials, case control, cohort research, etc.), and the faculties' commitment to collaborative research. [unreadable] [unreadable]..
  49. Trends in and Outcomes of Medication Use in Older Adults
    Bruce Psaty; Fiscal Year: 2004
    ..abstract_text> ..
  50. Utility of a New Database to Study Drug Safety during Pregnancy
    SOKO SETOGUCHI IWATA; Fiscal Year: 2008
    ..This database based on large population-based follow-up data with linkable clinical birth data has the potential to enhance the safety of prescription drug use in pregnant women and their children. [unreadable] [unreadable] [unreadable]..
  51. Molecular determinants of exercise-induced muscle damage
    Monica Hubal; Fiscal Year: 2004
    ..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
  52. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  53. Coenzyme Q10 in Aging: A Planning Grant
    Beatrice Golomb; Fiscal Year: 2005
    ..Thus there is strong conceptual as well as clinical rationale for assessing whether Q10 provides QOL & functional benefits in aging and whether it protects against untoward events associated with age. ..
  54. MOLECULAR STUDIES OF GENE TARGETED OLIGONUCLEOTIDES
    CY STEIN; Fiscal Year: 2002
    ..Finally, in Specific Aim 3, we will amplify the delivery of alt-OMPs and chi-OMPs to cells by condensing them with a novel delivery agent, tetra (N-methylpyridyl) porphine. ..
  55. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  57. STATINS AND NON-CARDIAC ENDPOINTS
    Beatrice Golomb; Fiscal Year: 2003
    ....
  58. Orthogonal Strategies for Specific Knockout Production
    CY STEIN; Fiscal Year: 2005
    ..Finally, in Specific Aim 4, we will evaluate the molecular consequences of the down regulation of bcl-2 and bcl-xL by employing the 12,000 gene-containing Affymetrix oligonucleotide microarray technology. ..
  59. Characteristics and Costs of Impaired Fasting Glucose
    Gregory Nichols; Fiscal Year: 2005
    ..Finally, we will calculate and compare the costs of medical care for patients in each FPG stage, and estimate multivariate models to identify factors that contribute to medical costs in each stage. ..