Genomes and Genes
Summary: Inflammation of skeletal muscle (MUSCLE, SKELETAL). Infectious, autoimmune, and paraneoplastic processes represent some of the more common conditions that may be associated with myositis. (From Adams et al., Principles of Neurology, 6th ed., pp 1402-13)
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications349 found, 100 shown here
- Genetic risk and protective factors for the idiopathic inflammatory myopathiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA
Curr Rheumatol Rep 11:287-94. 2009The idiopathic inflammatory myopathies, or myositis syndromes, are heterogeneous autoimmune diseases defined by chronic muscle inflammation of unknown cause...
- Bacterial, fungal, parasitic, and viral myositisNancy F Crum-Cianflone
Infectious Diseases Division, Naval Medical Center, San Diego, California 92134 1005, USA
Clin Microbiol Rev 21:473-94. 2008Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection...
- Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathwayBrandon W Higgs
Translational Sciences, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
Ann Rheum Dis 70:2029-36. 2011....
- Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesisNestor E Rulli
Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Southport, Australia
J Infect Dis 204:1026-30. 2011..Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were ..
- Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathiesIra N Targoff
Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Rheum Dis Clin North Am 28:859-90, viii. 2002..tests that detect markers of the disease process, including serum autoantibodies that have been associated with myositis; and (3) general laboratory tests that are used to assess the patient's general status and medical condition...
- Clinical features of influenza A and B in children and association with myositisJen Jan Hu
Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan, ROC
J Microbiol Immunol Infect 37:95-8. 2004..Acute childhood myositis associated with influenza occurs mostly in influenza B infection...
- Interstitial lung disease in myositis: clinical subsets, biomarkers, and treatmentTsuneyo Mimori
Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
Curr Rheumatol Rep 14:264-74. 2012Interstitial lung disease (ILD) is the most frequent organ involvement (found in nearly half) of myositis patients, but it reveals various clinical courses and therapeutic responsiveness according to clinical and serological subsets...
- Mannose binding lectin is required for alphavirus-induced arthritis/myositisBronwyn M Gunn
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Pathog 8:e1002586. 2012..River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host ..
- A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistenceThomas E Morrison
Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
Am J Pathol 178:32-40. 2011..Histologic analysis of hind limb sections revealed severe necrotizing myositis, mixed inflammatory cell arthritis, chronic active tenosynovitis, and multifocal vasculitis...
- Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathyLivia Casciola-Rosen
Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Exp Med 201:591-601. 2005..association, we examined autoantigen expression in normal muscle and in muscle from patients with autoimmune myositis. Although myositis autoantigens are expressed at very low levels in control muscle, they are found at high levels ..
- Autoantibody profiles in the sera of European patients with myositisR Brouwer
Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
Ann Rheum Dis 60:116-23. 2001OBJECTIVE: To determine the prevalence of myositis specific autoantibodies (MSAs) and several myositis associated autoantibodies (MAAs) in a large group of patients with myositis...
- Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirusBrett A Lidbury
Virus and Inflammation Research Group, Faculty of Sciences, University of Canberra, Australia
J Infect Dis 197:1585-93. 2008..To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection.
- Pathology of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salarR T Kongtorp
National Veterinary Institute, Oslo, Norway
Dis Aquat Organ 59:217-24. 2004..Microscopic lesions are compared and discussed in relation to published descriptions of pancreas disease (PD) and cardiomyopathy syndrome (CMS). It is concluded that HSMI is histopathologically distinguishable from PD and CMS...
- Experimental influenza B viral myositisL E Davis
Neurology Service, New Mexico VA Health Care System, University of New Mexico School of Medicine, 1501 San Pedro Drive SE, Albuquerque, NM 87108, USA
J Neurol Sci 187:61-7. 2001To investigate the pathogenesis of influenza myositis in animals, juvenile BALB/c mice were inoculated with influenza B/Lee virus intramuscularly into the right quadriceps muscle...
- FOXP3+ T regulatory cells in idiopathic inflammatory myopathiesAnne Waschbisch
Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
J Neuroimmunol 225:137-42. 2010..Here we studied the presence and potential role of FOXP3+ Tregs in myositis. CD3 and FOXP3 expression in dermatomyositis, polymyositis and inclusion body myositis was assessed by ..
- A case of benign acute childhood myositis associated with influenza A (H1N1) virus infectionM Koliou
Paediatric Department, Archbishop Makarios Hospital, Nicosia, Cyprus
Clin Microbiol Infect 16:193-5. 2010Benign acute childhood myositis (BACM) is a rare transient condition usually occurring at the early convalescent phase of a viral upper respiratory tract illness, normally influenza A, and, more frequently, influenza B infection...
- Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathiesDominique Figarella-Branger
Laboratoire de Biopathologie Nerveuse et Musculaire EA 3281, Faculte de Medecine Timone, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille, France
Muscle Nerve 28:659-82. 2003The inflammatory myopathies include dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (s-IBM)...
- Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significanceTsuneyo Mimori
Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Curr Opin Rheumatol 19:523-9. 2007..This review examines recent progress in myositis-specific autoantibodies, particularly in their clinical significance and pathophysiological roles.
- Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonistRanjinidevi Ambalavanar
Department of Biomedical Sciences, University of Maryland, Baltimore, 21201, USA
Pain 120:53-68. 2006..These data further implicate CGRP and SP in deep tissue nociceptive mechanisms and suggest that peptide antagonists may have therapeutic potential for musculoskeletal pain...
- Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathiesM Tucci
DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari, Italy
Clin Exp Immunol 146:21-31. 2006..Measurement of IL-18 may thus predict the severity of both DM and PM...
- TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cellsChristian W Keller
Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
J Biol Chem 286:3970-80. 2011..Muscle biopsies from patients with sporadic inclusion body myositis, a well defined myopathy with chronic inflammation, showed that over 20% of fibers that contained autophagosomes ..
- Mechanisms of disease: signaling pathways and immunobiology of inflammatory myopathiesMarinos C Dalakas
Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1382, USA
Nat Clin Pract Rheumatol 2:219-27. 2006The signaling pathways involved in the immunobiology of polymyositis, dermatomyositis, and inclusion-body myositis are outlined in this Review, which is based on research performed during the past 10 years...
- Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic targetClara Crescioli
Department of Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy
Eur J Cell Biol 91:139-49. 2012..In conclusion, we sustain that pharmacological targeting of CXCL10 within muscular cells might contribute to keep in control pro-Th1 polarization of the immune/inflammatory response...
- Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort studyR Buchbinder
Department of Clinical Epidemiology, Suite 41, Cabrini Medical Centre, 183 Wattletree Road, Malvern, Victoria, Australia 3144
Ann Intern Med 134:1087-95. 2001The validity and magnitude of an association between myositis and malignant disease continue to be debated...
- Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathyHector Chinoy
The University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
Rheumatology (Oxford) 51:794-9. 2012..Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM...
- Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammationMaurizio Vitadello
Institute of Neuroscience Padova Section, Consiglio Nazionale delle Ricerche, Viale G, Colombo 3, 35121 Padova, Italy
Arthritis Res Ther 12:R52. 2010..MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of ..
- Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage indexLisa G Rider
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892 1301, USA
Arthritis Rheum 60:3425-35. 2009We undertook this study to validate the Myositis Damage Index (MDI) in juvenile and adult myositis, to describe the degree and types of damage and to develop predictors of damage.
- Molecular profiles of inflammatory myopathiesS A Greenberg
Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Neurology 59:1170-82. 2002..gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis.
- Newly identified autoantibodies: relationship to idiopathic inflammatory myopathy subsets and pathogenesisHarsha Gunawardena
Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath Institute for Rheumatic Diseases and School for Health, University of Bath, Bath, UK
Curr Opin Rheumatol 20:675-80. 2008..b>Myositis-specific autoantibodies target intracellular proteins involved in key processes such as translocation and nuclear ..
- A robust in vitro screening assay to identify NF-kappaB inhibitors for inflammatory muscle diseasesAndreas R Baudy
Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
Int Immunopharmacol 9:1209-14. 2009....
- Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathiesJ L De Bleecker
Neurology Department, University Hospital, Gent, Belgium
Neuromuscul Disord 9:239-46. 1999..We immunolocalized TNF-alpha and its receptors in polymyositis, inclusion body myositis and dermatomyositis...
- Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhoodBrian M Feldman
Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
Lancet 371:2201-12. 2008..Disease outcome, if treatment is initiated early, is generally good. Randomised controlled trials are needed to define the most effective treatments...
- In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung diseaseR La Corte
Ferrara University, Rheumatology Section, Department of Clinical and Experimental Medicine, Ferrara, Italy
Autoimmunity 39:249-53. 2006..During a follow up of about 3 years (range 6-110 months), the presence of anti-Jo-1 antibody alone or in association with anti-Ro/SSA did not influence survival or a more severe prognosis of ILD...
- Role of cytokines and chemokines in idiopathic inflammatory myopathiesBoel De Paepe
Department of Neurology and Neuromuscular Reference Center, Laboratory for Myopathology, Ghent University Hospital, Ghent, Belgium
Curr Opin Rheumatol 21:610-6. 2009..This review focuses on the most recent data and the new insight they provide for the disease mechanisms of dermatomyositis, polymyositis and sporadic inclusion body myositis.
- Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell folliclesMohammad Salajegheh
Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Muscle Nerve 42:576-83. 2010b>Myositis muscle contains antigen-matured B-cells and plasma cells. Myositis muscle biopsy specimens were examined for nodular collections of T-cells, B-cells, myeloid dendritic cells, plasma cells, and follicular dendritic cells...
- Type I interferon and Toll-like receptor expression characterizes inflammatory myopathiesC Cappelletti
Department of Neurology IV, Neurological Institute Foundation Carlo Besta, Via Celoria 11, 20133 Milan, Italy
Neurology 76:2079-88. 2011..Recent evidence suggests a key role for type I interferon (IFN)-mediated innate immunity in dermatomyositis, which we explored in JDM, dermatomyositis, and PM by gene expression profiling, and other methods...
- Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathiesH Chinoy
The University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD
Rheumatology (Oxford) 46:1411-6. 2007..To investigate haplotype tagging single nucleotide polymorphisms (SNPs) in the tumour necrosis factor alpha (TNF-alpha) gene, in UK Caucasian idiopathic inflammatory myopathy (IIM) patients...
- Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositisThomas E Morrison
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Virol 80:737-49. 2006..These results establish the mouse model of RRV disease as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.
- Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligandPeter Szodoray
Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
Rheumatology (Oxford) 49:1867-77. 2010Serum cytokines play an important role in the pathogenesis of myositis by initiating and perpetuating various cellular and humoral autoimmune processes...
- Heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L: a new infectious diseaseR T Kongtorp
National Veterinary Institute, Oslo, Norway
J Fish Dis 27:351-8. 2004..Further investigations are required in order to make conclusions regarding the cause and pathogenesis of HSMI...
- Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositisStuart M Levine
Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Arthritis Rheum 56:2729-39. 2007..The strong association of autoantibodies to histidyl-transfer RNA synthetase (HisRS, Jo-1) with interstitial lung disease in patients with myositis led us to study HisRS expression and conformation in the lung.
- Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositisG Chevrel
Department of Immunology and Rheumatology, Hopital E Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
J Neuroimmunol 137:125-33. 2003..Our study shows that low levels of cytokines produced by T cells (IL-17) and monocytes (IL-1 beta) can act in combination on skeletal myoblasts and muscle tissue...
- The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathyWilliam Coley
Children s National Medical Center, Washington, DC, USA
Arthritis Rheum 64:3750-9. 2012..In particular, it has been suggested that an acquired deficiency of AMP deaminase 1 (AMPD1) may be responsible for muscle weakness in myositis.
- Clinical characteristics of patients with myositis and autoantibodies to different fragments of the Mi-2 beta antigenG J D Hengstman
Neuromuscular Centre Nijmegen, Department of Neurology, University Medical Centre Nijmegen, PO Box 9101, Internal Code 935, 6500 HB Nijmegen, The Netherlands
Ann Rheum Dis 65:242-5. 2006To assess the clinical implications of autoantibodies directed against different parts of the Mi-2 beta autoantigen in patients with myositis.
- Treatment of inflammatory muscle disease in adultsAnne Tournadre
Service de Rhumatologie, Hopital G Montpied, CHU Clermont Ferrand, Clermont Ferrand Cedex 1, France
Joint Bone Spine 77:390-4. 2010..immunopathological criteria are classically used to distinguish polymyositis, dermatomyositis, and inclusion body myositis. Major obstacles to controlled therapeutic trials in patients with inflammatory muscle diseases include the ..
- Decay-accelerating factor 1 deficiency exacerbates Trypanosoma cruzi-induced murine chronic myositisMaria E Solana
Microbiology, Parasitology, and Immunology Department, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Muscle Nerve 46:582-7. 2012..cruzi (Tc) has been used to study the role of T-cells in the pathogenesis of human inflammatory idiopathic myositis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity.
- Short-term and long-term outcome of anti-Jo1-positive patients with anti-Ro52 antibodyIsabelle Marie
Department of Internal Medicine, CHU Rouen, and INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France
Semin Arthritis Rheum 41:890-9. 2012....
- The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patientsH Chinoy
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK
Arthritis Rheum 58:3247-54. 2008..To examine single-nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase N22 gene (PTPN22) and to study the relationship between PTPN22 and the HLA region in patients with idiopathic inflammatory myopathies (IIMs)...
- 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The NetherlandsJessica E Hoogendijk
Department of Neurology, University Medical Center, Heidelberg laan 100, Utrecht, CX 3584, The Netherlands
Neuromuscul Disord 14:337-45. 2004
- Differential immunohistological features of inflammatory myopathies and dysferlinopathyJae Hwan Choi
Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea
J Korean Med Sci 24:1015-23. 2009..The analysis of inflammatory cells, MHC class I expressions and MAC deposits may help to differentiate dysferlinopathy from idiopathic inflammatory myopathy...
- Human muscle protein degradation in vitro by eosinophil cationic protein (ECP)R Sugihara
Third Department of Internal Medicine, Oita Medical University, Hasama 1-1, Oita 879-5593, Japan
Muscle Nerve 24:1627-34. 2001..that tissue eosinophils have a specific role in muscle fiber degradation in some myopathies associated with numerous tissue eosinophils, such as eosinophilic myositis, eosinophilic myalgia syndrome, and eosinophilic endocardial disease.
- Myositis-related interstitial lung disease and antisynthetase syndromeJoshua Solomon
Interstitial Lung Disease Program, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
J Bras Pneumol 37:100-9. 2011In patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies marks the presence or predicts the development of interstitial lung disease (ILD)...
- Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositisAli Zaid
University of Canberra, Canberra, Australian Capital Territory, Australia
Arthritis Rheum 63:488-91. 2011..This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease...
- Benign acute myositis associated with H1N1 influenza A virus infectionEsther Rubín
Department of Pediatrics, Marques de Valdecilla Hospital, University of Cantabria, 39008 Santander, Cantabria, Spain
Eur J Pediatr 169:1159-61. 2010We report the clinical and laboratory features of four children with benign acute myositis observed during the current outbreak of the novel H1N1 influenza A virus...
- A large outbreak of influenza B-associated benign acute childhood myositis in Germany, 2007/2008Sabine Mall
NRW Institute of Health and Work, Centre for Public Health, Muenster, Germany
Pediatr Infect Dis J 30:e142-6. 2011Benign acute childhood myositis (BACM) is a rare syndrome associated with various viral infections. Bilateral calve pain may lead to inability to walk...
- Beta-chemokine receptor expression in idiopathic inflammatory myopathiesBoel De Paepe
Department of Neurology, Neuromuscular Laboratory, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Muscle Nerve 31:621-7. 2005..We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DM), and control samples. CCR1-5 were localized to blood vessels in all samples...
- Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung diseaseI N Targoff
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
Arthritis Rheum 35:821-30. 1992..describe the clinical associations of the antibody, in particular, whether it is associated with the syndrome of myositis and interstitial lung disease (ILD) that has been previously associated with autoantibodies to the aminoacyl-tRNA ..
- Necrotizing myositis and septic shock caused by Haemophilus influenzae type f in a previously healthy man diagnosed with an IgG3 and a mannose-binding lectin deficiencyFredrik Resman
Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skane University Hospital, SE 20502 Malmo, Sweden
Scand J Infect Dis 43:972-6. 2011..We present here a dramatic case of Hif necrotizing myositis and septic shock...
- High frequencies and co-existing of myositis-specific autoantibodies in patients with idiopathic inflammatory myopathies overlapped to rheumatoid arthritisAyako Nakajima
Institute of Rheumatology and Aoyama Hospital, Tokyo Women s Medical University, 10 22 Kawada cho, 162 0054 Shinjuku ku, Tokyo, Japan
Rheumatol Int 32:2057-61. 2012..Clinical and laboratory data, including autoantibody test results, were collected from patient medical records. Myositis-specific antibodies (MSAs) were analyzed by immunoprecipitation...
- Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patientsYves Troyanov
Division of Rheumatology, Department of Medicine, Centre Hospitalier, Universite de Montreal, Faculty of Medicine, Montreal, Quebec, Canada
Medicine (Baltimore) 84:231-49. 2005..significance to the presence of overlap features, that is, their presence resulted in a diagnosis of overlap myositis (OM). This approach allowed direct comparison with the original Bohan and Peter classification...
- The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditisD L Defosse
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
Am J Pathol 141:3-10. 1992..burgdorferi resulting in pancarditis, synovitis, and skeletal interstitial myositis whereas controls remained normal...
- Review article: the gastrointestinal complications of myositisE C Ebert
Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Aliment Pharmacol Ther 31:359-65. 2010..The three major diseases are dermatomyositis, polymyositis and inclusion body myositis.
- Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cellsO M Zack Howard
National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
J Exp Med 196:781-91. 2002..aminoacyl-tRNA synthetases, perhaps liberated from damaged muscle cells, may perpetuate the development of myositis by recruiting mononuclear cells that induce innate and adaptive immune responses...
- VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury modelChristoph Spang
Section for Anatomy, Department of Integrative Medical Biology, Umea University, 901 87, Umea, Sweden
Inflammation 35:39-48. 2012It is not known whether a glutamate signaling system is involved in muscle inflammation (myositis)...
- Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositisLara J Herrero
Virus and Inflammation Research Group, Faculty of Applied Science, University of Canberra, Canberra, ACT 2601, Australia
Proc Natl Acad Sci U S A 108:12048-53. 2011..The prospect being that early treatment with MIF-blocking pharmaceuticals may curtail the debilitating arthritis associated with alphaviral infections...
- Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositisSimona Ozden
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
J Virol 78:10320-7. 2004..spastic paraparesis (HAM/TSP), concomitantly with or without other inflammatory disorders such as myositis. These pathologies are considered immune-mediated diseases, and it is assumed that migration within tissues of ..
- Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathiesCecilia Grundtman
Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
FASEB J 24:570-8. 2010..However, HMGB1-expressing fibers outnumbered fibers expressing MHC class I. Our data indicate that HMGB1 could be an early inducer of skeletal muscle dysfunction in IIMs...
- Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behaviorR Ambalavanar
Department of Biomedical Sciences and Program in Neuroscience, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
Neuroscience 143:875-84. 2006..The present data support the hypothesis that CGRP is upregulated during deep tissue inflammation and suggest that gene transcription is involved in this upregulation...
- Tropical pyomyositis (myositis tropicans): current perspectiveS Chauhan
Department of Internal Medicine, PGIMER, Chandigarh, India
Postgrad Med J 80:267-70. 2004..Treatment for Gram negative or anaerobic organisms should be instituted, whenever indicated. Physicians should become more familiar with this potentially life threatening but curable infective disease entity...
- Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patientsBrandon W Higgs
Translational Sciences, MedImmune, LLC, Gaithersburg, MD 20878, USA
Int J Rheum Dis 15:25-35. 2012....
- Acute pure motor quadriplegia: is it dengue myositis?J Kalita
Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India
Electromyogr Clin Neurophysiol 45:357-61. 2005..In view of paucity of comprehensive evaluation about dengue infection producing quadriplegia, we report the clinical, laboratory and neurophysiological studies in these patients...
- Tubulinosema sp. microsporidian myositis in immunosuppressed patientMaria M Choudhary
Cleveland Clinic Foundation, Department of Internal Medicine, 9500 Euclid Foundation, NA10, Cleveland, OH 44195, USA
Emerg Infect Dis 17:1727-30. 2011..We report an infection by Tubulinosema sp. in an immunosuppressed patient...
- The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damageHeather M Alger
Children s National Medical Center and George Washington University Medical Center, Washington, DC, USA
Arthritis Rheum 63:3448-57. 2011..cells are relatively resistant to classic apoptosis, and the factors initiating cell death and damage in myositis are not well defined. We hypothesized that nonimmune autophagic cell death may play a role in muscle fiber damage...
- International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset diseaseD A Isenberg
Center for Rheumatology, Department of Medicine, The Middlesex Hospital, University College London, London, UK
Rheumatology (Oxford) 43:49-54. 2004..To devise new tools to assess activity and damage in patients with idiopathic myopathies (IIM)...
- HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:3670-81. 2006..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
- The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositisHector Chinoy
Rheumatic Diseases Centre, Hope Hospital, The University of Manchester, Salford, UK
Ann Rheum Dis 66:1345-9. 2007There is a known association between myositis and cancer. The risk is greater in dermatomyositis (DM) than polymyositis (PM), although reliable methods to predict cancer risk in specific patients with myositis are not presently available...
- Influenza myocarditis and myositis: case presentation and review of the literatureKanwal Kumar
Institute of Cardiovascular Sciences, St Boniface Research Centre, Winnipeg, Manitoba, Canada
Can J Cardiol 27:514-22. 2011..Despite common pathogens, concomitant myocarditis and myositis remains a rare event...
- Clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathyL G Rider
Center for Biologics Evaluation and Research, FDA, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 41:710-9. 1998..To describe the clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy (IIM) and to compare these with the features of sporadic IIM...
- Trachipleistophora hominis infection in the myocardium and skeletal muscle of a patient with AIDSA Curry
Health Protection Agency, Manchester Royal Infirmary, Clinical Sciences Building, Oxford Road, Manchester M13 9WL, UK
J Infect 51:e139-44. 2005..To review the literature relevant to microsporidial infection of muscle and to describe a case of human microsporidial infection involving both skeletal and cardiac muscle...
- An update on the immunogenetics of idiopathic inflammatory myopathies: major histocompatibility complex and beyondHector Chinoy
The University of Manchester Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Salford, UK
Curr Opin Rheumatol 21:588-93. 2009..To update the reader on immunogenetic advances in idiopathic inflammatory myopathy (IIM) over the past 18 months...
- Myopathy with antibodies to the signal recognition particle: clinical and pathological featuresT Miller
Washington University School of Medicine, Department of Neurology, St Louis, Missouri 63110, USA
J Neurol Neurosurg Psychiatry 73:420-8. 2002To study myopathies with serum antibodies to the signal recognition particle (SRP), an unusual, myositis specific antibody associated syndrome that has not been well characterised pathologically.
- Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogenChristina M Coyle
Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA
N Engl J Med 351:42-7. 2004
- Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathiesMasahiro Kondo
Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
Immunology 128:e589-99. 2009....
- Acute dengue virus myositis: a report of seven patients of varying clinical severity including two cases with severe fulminant myositisVimal Kumar Paliwal
Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
J Neurol Sci 300:14-8. 2011Acute dengue myositis is characterized by fever and myalgia (with or without muscle weakness).
- MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasmMichele Gaeta
Department of Radiological Sciences, University of Messina, AOU Policlinico G Martino, Messina, Italy
Skeletal Radiol 38:571-8. 2009The authors describe magnetic resonance (MR) findings in eight patients with histologically confirmed focal myositis.
- Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expressionHarsha Gunawardena
Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UK
Rheumatology (Oxford) 48:607-12. 2009..Over the last few years, myositis-specific autoantibodies (MSAs) have been better characterized including autoantibodies directed against the ..
- HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathyHector Chinoy
Centre for Integrated Genomic Medical Research, University of Manchester, UK
Rheumatology (Oxford) 48:1213-7. 2009..The HLA-DPB1 gene is centromeric to other HLA class II loci and separated by a recombination hotspot. We investigated whether HLA-DPB1 associations differ between anti-Jo-1 and anti-PM-Scl antibody-positive IIM cases...
- Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assayAnna Ghirardello
Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
Rheumatology (Oxford) 49:2370-4. 2010Serological testing for myositis-specific or associated autoantibodies [myositis-specific antibody (MSA) and myositis-associated antibody (MAA)] is useful for the diagnosis of idiopathic inflammatory myopathies (IIMs)...
- Inflammatory myopathies: evaluation and managementSteven A Greenberg
Department of Neurology, Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women sHospital, and Harvard Medical School, Boston, MA 02115, USA
Semin Neurol 28:241-9. 2008The inflammatory myopathies, including dermatomyositis, inclusion body myositis, and polymyositis, are poorly understood autoimmune diseases affecting skeletal muscle...
- Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasiansTerrance P O'Hanlon
National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
Medicine (Baltimore) 84:338-49. 2005..were exclusive protective factors for the CD8+ T cell-mediated IIM forms of polymyositis (PM) and inclusion body myositis (IBM) (pc < 0.005)...
- Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteinsNestor E Rulli
Faculty of Applied Science, University of Canberra, Canberra, ACT, Australia
Arthritis Rheum 60:2513-23. 2009..The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice...
- Proteomic analysis of inclusion body myositisJie Li
Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
J Neuropathol Exp Neurol 65:826-33. 2006Sporadic inclusion body myositis (IBM) is the most frequently acquired inflammatory myopathy of late adult life, yet its diagnostic criteria and pathogenesis remain poorly defined...
- A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodiesMaija Leena Eloranta
Uppsala University, Uppsala, Sweden
Arthritis Rheum 56:3112-24. 2007To investigate type I interferon (IFN) system activation and its correlation with autoantibodies and organ manifestations in polymyositis (PM), dermatomyositis (DM), and inclusion body myositis.
- Anti-Jo-1 antibody levels correlate with disease activity in idiopathic inflammatory myopathyKerry B Stone
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Arthritis Rheum 56:3125-31. 2007Previous case series have examined the relationship between anti-Jo-1 antibody levels and myositis disease activity, demonstrating equivocal results...
- Defining Clinical Improvement in Adult and Juvenile MyositisLisa G Rider
Enviromental Autoimmunity Group, National Institute of Enviromental Health Sciences, National Institutes of Health, Bethesda, MD 20892, USA
J Rheumatol 30:603-17. 2003..rehabilitation medicine physicians, statisticians, and patient support group leaders, called the International Myositis Outcome Assessment Collaborative Study Group (IMACS), is engaged in developing consensus on the assessment of ..
- Inflammatory muscle diseases: a critical review on pathogenesis and therapiesMarinos C Dalakas
Department of Neurosciences, Imperial College, London, UK
Curr Opin Pharmacol 10:346-52. 2010..the most common immune inflammatory muscle disorders include Dermatomyositis (DM), Polymyositis (PM), Necrotizing Myositis (NM), and sporadic Inclusion Body Myositis (sIBM)...
- West Nile virus encephalitis with myositis and orchitisRoger D Smith
Department of Pathology and Laboratory Medicine, Universityof Cincinnati Medical Center, OH 45267 0529, USA
Hum Pathol 35:254-8. 2004..Extra-CNS findings include myositis with T-lymphocyte infiltration of nerve fibers, suggesting that the virus may reach the CNS via peripheral nerves...
- A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathyLisa Christopher-Stine
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Arthritis Rheum 62:2757-66. 2010..The aim of this study was to identify novel autoantibodies in patients with necrotizing myopathy...
- Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositisCharles Kwok chong Li
Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
Am J Pathol 175:1030-40. 2009..Overexpression of MHC class I protein is a common feature of many muscle pathologies including idiopathic myositis and can induce ER stress...
- Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfallsAne Labirua
Internal Medicine Department, Vall d Hebron General Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
Curr Opin Rheumatol 22:633-8. 2010..To present the latest findings regarding interstitial lung disease (ILD) in idiopathic inflammatory myopathies, focusing on the phenotype of ILD and auto-antibodies, pathogenesis and treatment...
- Clinical and serological characteristics of 125 Dutch myositis patients. Myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathiesG J D Hengstman
Neuromuscular Centre Nijmegen, Institute of Neurology, University Medical Centre Nijmegen, The Netherlands
J Neurol 249:69-75. 2002..that include the familiar disease entities of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM)...
- Preclinical drug trial in mouse models of inflammationKanneboyina Nagaraju; Fiscal Year: 2011..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
- Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic cluesLauren M Pachman; Fiscal Year: 2013..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
- Preclinical drug trial in mouse models of inflammationKanneboyina Nagaraju; Fiscal Year: 2013..This program will help the Candidate to train and develop scientists interested in drug development in academic settings. These efforts in the long term will help us to develop specific drugs for inflammatory diseases. ..
- Mapping Orofacial Nociceptive Pathways and Alterations Due to InflammationJOSHUA EMRICK; Fiscal Year: 2013..connective tissues supporting the dentition (gingivitis and periodontitis), muscles involved in mastication (myositis), or temporomandibular joint (arthritis or temporomandibular disorder/TMD)...
- Acquisition of a TIRF/Widefield fluorescence microscope for cell biology and neurBryon D Grove; Fiscal Year: 2013..of North Dakota including Alzheimers[unreadable] disease, Parkinson[unreadable]s disease, inclusion body myositis (IBM), epilepsy and many more...
- Functional impact of dendritic cell phenotype in a mouse model of myositisDana P Ascherman; Fiscal Year: 2010..The latter objective is relevant to the treatment of multiple autoimmune diseases for which global immunosuppression is the only therapeutic option. ..
- Role of Presenilin in Idiopathic Dilated CardiomyopathyFederica Del Monte; Fiscal Year: 2013..such as primary systemic amyloidosis, diabetes, cystic fibrosis, neurodegenerative diseases and inclusion body myositis. Although the molecular mechanisms by which these pathologies develop might be different, they are recently been ..
- Contribution of catabolite control protein A to group A streptococcal virulenceSamuel A Shelburne; Fiscal Year: 2013..GAS gene expression during infection in mouse muscle;2) Inactivation of CcpA decreased GAS virulence in a mouse myositis model;3) Mutation of the central CpG of a GAS cre site decreased CcpA-(HPr-Ser46-P) DNA binding affinity;and 4) ..
- The Role of IL-17 Axis in Inflammatory MyositisAnn M Reed; Fiscal Year: 2013..of uncommon but life- and organ-threatening autoimmune syndromes collectively known as idiopathic inflammatory myositis (IIM). Patients with DM suffer debilitating muscle weakness, respiratory impairment, and disfiguring skin rashes...
- A device for rapid, painless, bedside muscle evaluation of childrenJOSE LUIS BOHORQUEZ; Fiscal Year: 2012..Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and inflammatory myositis, and affect well over 100,000 children in the United States alone...
- Post-9/11 Incidence of Systemic Autoimmune Diseases in the FDNY CohortMayris P Webber; Fiscal Year: 2013..SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc;both diffuse and limited), inflammatory myositis (dermatomyositis, polymyositis, or inclusion-body myositis), Sjogren's syndrome, rheumatoid arthritis (RA), ..
- Multiparametric Classification of Muscle Damage in Inflammatory MyopathyJane Park; Fiscal Year: 2013..idiopathic inflammatory myopathies (IIM), including dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM), are autoimmune diseases resulting in muscle inflammation, weakness, and pain...
- Pathogenesis of Arthritis and Myositis-Associated AlphavirusesThomas E Morrison; Fiscal Year: 2010..Relevance: Arthritis/myositis-associated alphaviruses are an emerging threat due to their ability to initiate explosive epidemics and to cause ..
- Rituximab Therapy in Refractory Adult and Juvenile IIMCHARLES ODDIS; Fiscal Year: 2010..It has also been studied and used in small numbers of patients with myositis. This study will evaluate the efficacy of rituximab in treating refractory adult and pediatric patients with ..
- Rituximab Therapy in Refractory Adult and Juvenile IIMCHARLES ODDIS; Fiscal Year: 2009..It has also been studied and used in small numbers of patients with myositis. This study will evaluate the efficacy of rituximab in treating refractory adult and pediatric patients with ..
- TRIM Interactions with Arthritic AlphavirusesMark T Heise; Fiscal Year: 2013..such as Chikungunya virus (CHIKV) and Ross River virus (RRV) cause severe acute and persistent arthritis and myositis in infected humans and are significant emerging disease threats...
- Structural insight into the role of CHD4 PHD fingers.CATHERINE ANNE MUSSELMAN; Fiscal Year: 2011Human CHD4 (chromodomain helicase DMA-binding protein 4) is an autoantigen of myositis, an autoimmune disease associated with an increased risk of conjestive heart failure, arrhythmia, myocardial infarction and cardiac arrest...
- Discovery of Novel Autoantigens in Patients with Inclusion Body MyositisKEVIN C O'CONNOR; Fiscal Year: 2013DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness...
- Eosinophils support nematode infectionJudith A Appleton; Fiscal Year: 2012..We have discovered that eosinophils contribute to the ensuing myositis while simultaneously protecting larvae against immune-mediated destruction...
- Rheumatic Disease Sera: Probes of Disease MechanismsLivia A Casciola-Rosen; Fiscal Year: 2012..Recent studies have demonstrated that autoantigens in myositis are expressed at high levels in inflamed muscle, particularly in regenerating muscle cells...
- Role of RyRs, DHPRs and Ca2+ Entry in the Inclusion Body MyositisAlexander Shtifman; Fiscal Year: 2010..proteins on Ca2+ dysregulation in skeletal muscle as it relates to a skeletal muscle disorder, the Inclusion Body Myositis (IBM). Dr...
- Characterization of Autoreactivity to Muscle Proteins in Inclusion Body MyositisMohammad Salajegheh; Fiscal Year: 2013DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is a common inflammatory myopathy of the elderly...
- A Multidisciplinary Analysis of Gelsolin Amyloid DiseaseJeffery W Kelly; Fiscal Year: 2010..many features of FAF pathology, including the intracellular inclusions also associated with inclusion body myositis (IBM), the most common muscle degenerative disease in the aging population...
- Screening for drug targets in a Drosophila model of muscle degenerationEDWARD KWAME OWUSU ANSAH; Fiscal Year: 2010..e. the dystrophin model, parkin/pinkl model and a sporadic inclusion-body myositis model) to identify several muscle pan-degeneration markers...
- Pathogenesis of autoimmune myositis: Role of MHC Class 1Kanneboyina Nagaraju; Fiscal Year: 2009..The MHC class 1 mouse model of myositis is a powerful tool to identify such pathways...
- Eosinophils sustain chronic nematode infectionJudith A Appleton; Fiscal Year: 2010..We have discovered that eosinophils contribute to the ensuing myositis while simultaneously promoting protection of larvae against immune-mediated destruction...
- Persistent chikungunya virus infection and diseaseThomas E Morrison; Fiscal Year: 2012..We have developed a mouse model of CHIKV infection in which the major pathological outcomes, arthritis, myositis, and tenosynovitis, are consistent with the clinical signs experienced by the majority of CHIKV-infected humans...
- Idiopathic Inflammatory Myopathies: Improving Diagnosis and Predicting OutcomesLisa Christopher Stine; Fiscal Year: 2010..Allan Gelber, Antony Rosen, and Paul Plotz. IIM, including dermatomyositis, polymyositis, and inclusion body myositis, constitute the largest subset of acquired myopathies and often affect adults in their prime...
- The role of the dermatomyositis autoantigen MI-2 in muscle regenerationANDREW L MAMMEN; Fiscal Year: 2012..Recent data show low levels of myositis autoantigens (including Mi-2, a chromatin remodeling enzyme) in normal muscle...
- Naturally Occurring Dog Model for Juvenile DermatomyositisLeigh Anne Clark; Fiscal Year: 2013..This approach is innovative because it utilizes a naturally occurring dog model of disease to better understand the complex genetic factors that contribute to DM. ..
- Sialic acid has putative signaling roles in muscle disorders of agingNam Pham; Fiscal Year: 2013DESCRIPTION (provided by applicant): Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease associated with aging. sIBM afflicts individuals older than 50 years of age...
- Innate immune and metabolic pathway interactions in myositisTRAVIS KINDER; Fiscal Year: 2013..applicant): Skeletal muscle inflammation of unknown cause is referred to as idiopathic inflammatory myopathy, or myositis. Muscle weakness is one of the characteristic features of such disease conditions...
- Mechanisms of Response and Relapse in Rituximab-treated Myositis PatientsChester V Oddis; Fiscal Year: 2013DESCRIPTION (provided by applicant): Autoimmune (AI) inflammatory muscle diseases (myositis) include polymyositis (PM), adult dermatomyositis (DM) and juvenile dermatomyositis (JDM)...
- Functional Interactions Between Peripheral P2X3 and TRP ChannelsJAMI LYNN SALOMAN; Fiscal Year: 2012..The identification of new mechanisms underlying mechanical hyperalgesia during myositis conditions could contribute to alternative treatment strategies for the management of TMD and other muscle pain ..
- Treatment Strategies for Neuromuscular Diseases: The Challenge of RecruitmentRobert C Griggs; Fiscal Year: 2010....
- TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSIONDouglas Jasmer; Fiscal Year: 2001Trichinella spiralis is an intracellular nematode parasite of mammalian skeletal muscle cells that causes severe myositis and, sometimes, death in humans...
- TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITISFrank LaFerla; Fiscal Year: 2001..overall long-term objective of this FIRST proposal is to understand the molecular pathogenesis of inclusion body myositis (IBM), the most common muscle disease in personals over 50 years of age...
- MITOCHONDRIAL DNA DEPLETION IN HUMAN DISEASETuan Vu; Fiscal Year: 2000..such as autosomal dominant progressive external ophthalmoplegia with multiple deletions and inclusion-body myositis. Although the mechanisms leading to mtDNA depletion in these disorders are unknown, this type of depletion is ..
- Polyamine based Therapy of E. bieneusi Infected MiceVENUDHAR REDDY; Fiscal Year: 2006..common manifestation is gastrointestinal tract infection; however, encephalitis, ocular infection, sinusitis, myositis and disseminated infection are reported...
- TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNSMark T Heise; Fiscal Year: 2010..We and others have developed a mouse model of RRV-induced arthritis and myositis, where the virus replicates to high levels in the synovial joints and skeletal muscle, but virus induced disease ..
- Beta-Amyloid & Cell Death Mechanisms in Skeletal MuscleHenry Querfurth; Fiscal Year: 2005DESCRIPTION (Adapted from applicant's abstract): Inclusion Body Myositis (IBM) is the most common muscle disorder in patients over 50 years of age...
- Alzheimer Vaccines: Noninvasive Vaccination by DNA-Base*Ken Ichiro Fukuchi; Fiscal Year: 2005Alzheimer's disease (AD) and inclusion-body myositis (IBM) are the most common degenerative diseases in brain and skeletal muscle, respectively, in people over age 50 years...
- HLA RELATIONSHIPS OF PREGNANCY, CHIMERISM & AUTOIMMUNITYJ Nelson; Fiscal Year: 1999..and have clinical features in common with some human autoimmune disease such as scleroderma, Sjogren's syndrome, myositis, primary biliary cirrhosis and systemic lupus erythematosus (SLE)...
- MULTIPURPOSE ARTHRITIS CENTERCharles Christian; Fiscal Year: 1980..Seven patients with myositis and serologic evidence of recent toxoplasmodis have been studied in assays of cellular immunity...
- IMMUNOPATHIC MYOSITIS INDUCED BY PERSISTENT VIRUSRonald Messner; Fiscal Year: 2002..Focused, mechanistic hypotheses can then be developed to explore these interactions in future studies. ..
- Viral dsRNA as a Mediator of Chronic Muscle DiseasesPATRICIA TAM; Fiscal Year: 2005..The results will advance the development of better tools for the epidemiologic study, diagnosis, and treatment of diseases where enterovirus infection has been implicated. ..
- Modulating IBM pathology in transgenic miceFrank LaFerla; Fiscal Year: 2005..to develop and characterize novel transgenic mouse models to study the molecular pathogenesis of inclusion body myositis (IBM)...
- Skin-patch Vaccination against Alzheimer's DiseaseKen Ichiro Fukuchi; Fiscal Year: 2002Alzheimer's disease (AD) and inclusion body myositis (IBM) share a number of common pathologies such as deposits of amyloid beta-protein (AB) and paired helical filaments, although such pathologies are mostly restricted to brain for AD ..
- Finalization of Outcomes and Design Issues for MyositisAnn Reed; Fiscal Year: 2001..This study will develop the validated outcome measures needed and set the stage to allow for the successful completion of large multicenter trials in the Idiopathic Inflammatory myopathies. ..
- ECTOPIC EXPRESSION OF THE PRION PROTEINPatrick Bosque; Fiscal Year: 1999..in these animals may also demonstrate similarities between the mechanism of prion disease and inclusion body myositis or type Il diabetes mellitus. If so, these animals may serve as models of these conditions...
- MAMDC--UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINEDavid Glass; Fiscal Year: 2000..H. Giannini, MSc, DrPH 2) Molecular Genotyping and Sequencing; -S.D. Thompson, PhD Establishment of the MAMDC will promote innovative approaches to laboratory an clinical research. ..
- RNA Polymerase Sigma Factors in Streptococcus pyogenesCHARLES MORAN; Fiscal Year: 2005..acute glomerulonephritis, and possibly pediatric neuropsychological disorders, to severe invasive diseases like myositis and streptococcal toxic shock syndrome...
- IMMUNOPATHOGENESIS OF EXPERIMENTAL ALLERGIC MYOSITISAbdolmohamad Rostami; Fiscal Year: 1993..Experimental allergic myositis (EAM) is a useful animal model for human polymyositis...
- PLANNING GRANT FOR A MULTIPURPOSE CLINICAL RES CENTERMorris Reichlin; Fiscal Year: 1999..is to promote high quality clinical research in systemic lupus erythematosus, rheumatoid arthritis, inflammatory myositis and Wegener's granulomatosus...
- Untreated DQA1*0501+JDM:Clinical and Genetic ProfilesLauren Pachman; Fiscal Year: 2006..Specific Aim 3 will characterize the gene expression profiles in JDM as well as children with myositis related antibodies, who have nonremittent disease...
- Dermatomyositis Skin Disease Severity Measure ValidationJOSPEH JORIZZO; Fiscal Year: 2003..abstract_text> ..
- Proteomic Studies in Inclusion Body MyositisSteven Greenberg; Fiscal Year: 2009DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is a disease of unknown cause characterized by slowly progressive painless weakness and with no effective treatment...
- Injured Muscle: Effect on Neutrophil FunctionFRANCIS PIZZA; Fiscal Year: 2003....
- Role of RyRs and DHPRs and Ca2+ Entry in beta-amyloid mediated Ca2+ dysregulationAlexander Shtifman; Fiscal Year: 2009..clinical scientist with extensive experience in adenoviral gene delivery and in the field of the Inclusion Body Myositis (IBM) and Dr. Lopez, who is an independent scientist with extensive experience in microelectrode recordings...
- AAA ATPase p97/VCP and Inclusion Body MyopathyCONRAD WEIHL; Fiscal Year: 2009..to investigate the cellular mechanisms of aging in relation to skeletal muscle disorders, using inclusion body myositis (IBM) as a prototypical disease. The mentored scientific training will be performed jointly in the labs of Drs...
- Gene Expression in Inflammatory MyopathiesSteven Greenberg; Fiscal Year: 2005..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
- MECHANISMS OF COXASACKIEVIRUS INDUCED POLYMYOSITISRonald Messner; Fiscal Year: 1992..The results of these experiments should provide important information that will enhance our understanding of the mechanism through which CVB1 induces an immunologically mediated myositis.