myositis

Summary

Summary: Inflammation of skeletal muscle (MUSCLE, SKELETAL). Infectious, autoimmune, and paraneoplastic processes represent some of the more common conditions that may be associated with myositis. (From Adams et al., Principles of Neurology, 6th ed., pp 1402-13)

Top Publications

  1. ncbi Genetic risk and protective factors for the idiopathic inflammatory myopathies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA
    Curr Rheumatol Rep 11:287-94. 2009
  2. pmc Bacterial, fungal, parasitic, and viral myositis
    Nancy F Crum-Cianflone
    Infectious Diseases Division, Naval Medical Center, San Diego, California 92134 1005, USA
    Clin Microbiol Rev 21:473-94. 2008
  3. ncbi Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway
    Brandon W Higgs
    Translational Sciences, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Ann Rheum Dis 70:2029-36. 2011
  4. ncbi Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
    Nestor E Rulli
    Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Southport, Australia
    J Infect Dis 204:1026-30. 2011
  5. ncbi Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Rheum Dis Clin North Am 28:859-90, viii. 2002
  6. ncbi Clinical features of influenza A and B in children and association with myositis
    Jen Jan Hu
    Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:95-8. 2004
  7. ncbi Interstitial lung disease in myositis: clinical subsets, biomarkers, and treatment
    Tsuneyo Mimori
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
    Curr Rheumatol Rep 14:264-74. 2012
  8. pmc Mannose binding lectin is required for alphavirus-induced arthritis/myositis
    Bronwyn M Gunn
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1002586. 2012
  9. pmc A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence
    Thomas E Morrison
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Pathol 178:32-40. 2011
  10. pmc Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    Livia Casciola-Rosen
    Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Exp Med 201:591-601. 2005

Detail Information

Publications349 found, 100 shown here

  1. ncbi Genetic risk and protective factors for the idiopathic inflammatory myopathies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA
    Curr Rheumatol Rep 11:287-94. 2009
    The idiopathic inflammatory myopathies, or myositis syndromes, are heterogeneous autoimmune diseases defined by chronic muscle inflammation of unknown cause...
  2. pmc Bacterial, fungal, parasitic, and viral myositis
    Nancy F Crum-Cianflone
    Infectious Diseases Division, Naval Medical Center, San Diego, California 92134 1005, USA
    Clin Microbiol Rev 21:473-94. 2008
    Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection...
  3. ncbi Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway
    Brandon W Higgs
    Translational Sciences, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Ann Rheum Dis 70:2029-36. 2011
    ....
  4. ncbi Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
    Nestor E Rulli
    Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Southport, Australia
    J Infect Dis 204:1026-30. 2011
    ..Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were ..
  5. ncbi Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies
    Ira N Targoff
    Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Rheum Dis Clin North Am 28:859-90, viii. 2002
    ..tests that detect markers of the disease process, including serum autoantibodies that have been associated with myositis; and (3) general laboratory tests that are used to assess the patient's general status and medical condition...
  6. ncbi Clinical features of influenza A and B in children and association with myositis
    Jen Jan Hu
    Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 37:95-8. 2004
    ..Acute childhood myositis associated with influenza occurs mostly in influenza B infection...
  7. ncbi Interstitial lung disease in myositis: clinical subsets, biomarkers, and treatment
    Tsuneyo Mimori
    Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Sakyo ku, Japan
    Curr Rheumatol Rep 14:264-74. 2012
    Interstitial lung disease (ILD) is the most frequent organ involvement (found in nearly half) of myositis patients, but it reveals various clinical courses and therapeutic responsiveness according to clinical and serological subsets...
  8. pmc Mannose binding lectin is required for alphavirus-induced arthritis/myositis
    Bronwyn M Gunn
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1002586. 2012
    ..River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host ..
  9. pmc A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence
    Thomas E Morrison
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Pathol 178:32-40. 2011
    ..Histologic analysis of hind limb sections revealed severe necrotizing myositis, mixed inflammatory cell arthritis, chronic active tenosynovitis, and multifocal vasculitis...
  10. pmc Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    Livia Casciola-Rosen
    Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Exp Med 201:591-601. 2005
    ..association, we examined autoantigen expression in normal muscle and in muscle from patients with autoimmune myositis. Although myositis autoantigens are expressed at very low levels in control muscle, they are found at high levels ..
  11. pmc Autoantibody profiles in the sera of European patients with myositis
    R Brouwer
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Ann Rheum Dis 60:116-23. 2001
    OBJECTIVE: To determine the prevalence of myositis specific autoantibodies (MSAs) and several myositis associated autoantibodies (MAAs) in a large group of patients with myositis...
  12. ncbi Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus
    Brett A Lidbury
    Virus and Inflammation Research Group, Faculty of Sciences, University of Canberra, Australia
    J Infect Dis 197:1585-93. 2008
    ..To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection.
  13. ncbi Pathology of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 59:217-24. 2004
    ..Microscopic lesions are compared and discussed in relation to published descriptions of pancreas disease (PD) and cardiomyopathy syndrome (CMS). It is concluded that HSMI is histopathologically distinguishable from PD and CMS...
  14. ncbi Experimental influenza B viral myositis
    L E Davis
    Neurology Service, New Mexico VA Health Care System, University of New Mexico School of Medicine, 1501 San Pedro Drive SE, Albuquerque, NM 87108, USA
    J Neurol Sci 187:61-7. 2001
    To investigate the pathogenesis of influenza myositis in animals, juvenile BALB/c mice were inoculated with influenza B/Lee virus intramuscularly into the right quadriceps muscle...
  15. ncbi FOXP3+ T regulatory cells in idiopathic inflammatory myopathies
    Anne Waschbisch
    Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
    J Neuroimmunol 225:137-42. 2010
    ..Here we studied the presence and potential role of FOXP3+ Tregs in myositis. CD3 and FOXP3 expression in dermatomyositis, polymyositis and inclusion body myositis was assessed by ..
  16. ncbi A case of benign acute childhood myositis associated with influenza A (H1N1) virus infection
    M Koliou
    Paediatric Department, Archbishop Makarios Hospital, Nicosia, Cyprus
    Clin Microbiol Infect 16:193-5. 2010
    Benign acute childhood myositis (BACM) is a rare transient condition usually occurring at the early convalescent phase of a viral upper respiratory tract illness, normally influenza A, and, more frequently, influenza B infection...
  17. ncbi Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies
    Dominique Figarella-Branger
    Laboratoire de Biopathologie Nerveuse et Musculaire EA 3281, Faculte de Medecine Timone, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Muscle Nerve 28:659-82. 2003
    The inflammatory myopathies include dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (s-IBM)...
  18. ncbi Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance
    Tsuneyo Mimori
    Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Curr Opin Rheumatol 19:523-9. 2007
    ..This review examines recent progress in myositis-specific autoantibodies, particularly in their clinical significance and pathophysiological roles.
  19. ncbi Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
    Ranjinidevi Ambalavanar
    Department of Biomedical Sciences, University of Maryland, Baltimore, 21201, USA
    Pain 120:53-68. 2006
    ..These data further implicate CGRP and SP in deep tissue nociceptive mechanisms and suggest that peptide antagonists may have therapeutic potential for musculoskeletal pain...
  20. pmc Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies
    M Tucci
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari, Italy
    Clin Exp Immunol 146:21-31. 2006
    ..Measurement of IL-18 may thus predict the severity of both DM and PM...
  21. pmc TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    Christian W Keller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:3970-80. 2011
    ..Muscle biopsies from patients with sporadic inclusion body myositis, a well defined myopathy with chronic inflammation, showed that over 20% of fibers that contained autophagosomes ..
  22. ncbi Mechanisms of disease: signaling pathways and immunobiology of inflammatory myopathies
    Marinos C Dalakas
    Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1382, USA
    Nat Clin Pract Rheumatol 2:219-27. 2006
    The signaling pathways involved in the immunobiology of polymyositis, dermatomyositis, and inclusion-body myositis are outlined in this Review, which is based on research performed during the past 10 years...
  23. ncbi Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic target
    Clara Crescioli
    Department of Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy
    Eur J Cell Biol 91:139-49. 2012
    ..In conclusion, we sustain that pharmacological targeting of CXCL10 within muscular cells might contribute to keep in control pro-Th1 polarization of the immune/inflammatory response...
  24. ncbi Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study
    R Buchbinder
    Department of Clinical Epidemiology, Suite 41, Cabrini Medical Centre, 183 Wattletree Road, Malvern, Victoria, Australia 3144
    Ann Intern Med 134:1087-95. 2001
    The validity and magnitude of an association between myositis and malignant disease continue to be debated...
  25. pmc Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy
    Hector Chinoy
    The University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
    Rheumatology (Oxford) 51:794-9. 2012
    ..Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM...
  26. pmc Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation
    Maurizio Vitadello
    Institute of Neuroscience Padova Section, Consiglio Nazionale delle Ricerche, Viale G, Colombo 3, 35121 Padova, Italy
    Arthritis Res Ther 12:R52. 2010
    ..MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis. The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of ..
  27. pmc Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index
    Lisa G Rider
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892 1301, USA
    Arthritis Rheum 60:3425-35. 2009
    We undertook this study to validate the Myositis Damage Index (MDI) in juvenile and adult myositis, to describe the degree and types of damage and to develop predictors of damage.
  28. ncbi Molecular profiles of inflammatory myopathies
    S A Greenberg
    Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Neurology 59:1170-82. 2002
    ..gene expression profiles to distinguish broad categories of myopathy and subtypes of inflammatory myopathies (IM) and to provide insight into the pathogenesis of inclusion body myositis (IBM), polymyositis, and dermatomyositis.
  29. ncbi Newly identified autoantibodies: relationship to idiopathic inflammatory myopathy subsets and pathogenesis
    Harsha Gunawardena
    Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath Institute for Rheumatic Diseases and School for Health, University of Bath, Bath, UK
    Curr Opin Rheumatol 20:675-80. 2008
    ..b>Myositis-specific autoantibodies target intracellular proteins involved in key processes such as translocation and nuclear ..
  30. pmc A robust in vitro screening assay to identify NF-kappaB inhibitors for inflammatory muscle diseases
    Andreas R Baudy
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Int Immunopharmacol 9:1209-14. 2009
    ....
  31. ncbi Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies
    J L De Bleecker
    Neurology Department, University Hospital, Gent, Belgium
    Neuromuscul Disord 9:239-46. 1999
    ..We immunolocalized TNF-alpha and its receptors in polymyositis, inclusion body myositis and dermatomyositis...
  32. ncbi Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood
    Brian M Feldman
    Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 371:2201-12. 2008
    ..Disease outcome, if treatment is initiated early, is generally good. Randomised controlled trials are needed to define the most effective treatments...
  33. ncbi In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease
    R La Corte
    Ferrara University, Rheumatology Section, Department of Clinical and Experimental Medicine, Ferrara, Italy
    Autoimmunity 39:249-53. 2006
    ..During a follow up of about 3 years (range 6-110 months), the presence of anti-Jo-1 antibody alone or in association with anti-Ro/SSA did not influence survival or a more severe prognosis of ILD...
  34. ncbi Role of cytokines and chemokines in idiopathic inflammatory myopathies
    Boel De Paepe
    Department of Neurology and Neuromuscular Reference Center, Laboratory for Myopathology, Ghent University Hospital, Ghent, Belgium
    Curr Opin Rheumatol 21:610-6. 2009
    ..This review focuses on the most recent data and the new insight they provide for the disease mechanisms of dermatomyositis, polymyositis and sporadic inclusion body myositis.
  35. ncbi Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
    b>Myositis muscle contains antigen-matured B-cells and plasma cells. Myositis muscle biopsy specimens were examined for nodular collections of T-cells, B-cells, myeloid dendritic cells, plasma cells, and follicular dendritic cells...
  36. ncbi Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies
    C Cappelletti
    Department of Neurology IV, Neurological Institute Foundation Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Neurology 76:2079-88. 2011
    ..Recent evidence suggests a key role for type I interferon (IFN)-mediated innate immunity in dermatomyositis, which we explored in JDM, dermatomyositis, and PM by gene expression profiling, and other methods...
  37. ncbi Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies
    H Chinoy
    The University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD
    Rheumatology (Oxford) 46:1411-6. 2007
    ..To investigate haplotype tagging single nucleotide polymorphisms (SNPs) in the tumour necrosis factor alpha (TNF-alpha) gene, in UK Caucasian idiopathic inflammatory myopathy (IIM) patients...
  38. pmc Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis
    Thomas E Morrison
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 80:737-49. 2006
    ..These results establish the mouse model of RRV disease as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.
  39. pmc Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand
    Peter Szodoray
    Institute of Immunology, Rikshospitalet, University of Oslo, Oslo, Norway
    Rheumatology (Oxford) 49:1867-77. 2010
    Serum cytokines play an important role in the pathogenesis of myositis by initiating and perpetuating various cellular and humoral autoimmune processes...
  40. ncbi Heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L: a new infectious disease
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    J Fish Dis 27:351-8. 2004
    ..Further investigations are required in order to make conclusions regarding the cause and pathogenesis of HSMI...
  41. ncbi Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis
    Stuart M Levine
    Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arthritis Rheum 56:2729-39. 2007
    ..The strong association of autoantibodies to histidyl-transfer RNA synthetase (HisRS, Jo-1) with interstitial lung disease in patients with myositis led us to study HisRS expression and conformation in the lung.
  42. ncbi Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis
    G Chevrel
    Department of Immunology and Rheumatology, Hopital E Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    J Neuroimmunol 137:125-33. 2003
    ..Our study shows that low levels of cytokines produced by T cells (IL-17) and monocytes (IL-1 beta) can act in combination on skeletal myoblasts and muscle tissue...
  43. pmc The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy
    William Coley
    Children s National Medical Center, Washington, DC, USA
    Arthritis Rheum 64:3750-9. 2012
    ..In particular, it has been suggested that an acquired deficiency of AMP deaminase 1 (AMPD1) may be responsible for muscle weakness in myositis.
  44. pmc Clinical characteristics of patients with myositis and autoantibodies to different fragments of the Mi-2 beta antigen
    G J D Hengstman
    Neuromuscular Centre Nijmegen, Department of Neurology, University Medical Centre Nijmegen, PO Box 9101, Internal Code 935, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 65:242-5. 2006
    To assess the clinical implications of autoantibodies directed against different parts of the Mi-2 beta autoantigen in patients with myositis.
  45. ncbi Treatment of inflammatory muscle disease in adults
    Anne Tournadre
    Service de Rhumatologie, Hopital G Montpied, CHU Clermont Ferrand, Clermont Ferrand Cedex 1, France
    Joint Bone Spine 77:390-4. 2010
    ..immunopathological criteria are classically used to distinguish polymyositis, dermatomyositis, and inclusion body myositis. Major obstacles to controlled therapeutic trials in patients with inflammatory muscle diseases include the ..
  46. ncbi Decay-accelerating factor 1 deficiency exacerbates Trypanosoma cruzi-induced murine chronic myositis
    Maria E Solana
    Microbiology, Parasitology, and Immunology Department, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Muscle Nerve 46:582-7. 2012
    ..cruzi (Tc) has been used to study the role of T-cells in the pathogenesis of human inflammatory idiopathic myositis. Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity.
  47. ncbi Short-term and long-term outcome of anti-Jo1-positive patients with anti-Ro52 antibody
    Isabelle Marie
    Department of Internal Medicine, CHU Rouen, and INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France
    Semin Arthritis Rheum 41:890-9. 2012
    ....
  48. ncbi The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients
    H Chinoy
    University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK
    Arthritis Rheum 58:3247-54. 2008
    ..To examine single-nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase N22 gene (PTPN22) and to study the relationship between PTPN22 and the HLA region in patients with idiopathic inflammatory myopathies (IIMs)...
  49. ncbi 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands
    Jessica E Hoogendijk
    Department of Neurology, University Medical Center, Heidelberg laan 100, Utrecht, CX 3584, The Netherlands
    Neuromuscul Disord 14:337-45. 2004
  50. pmc Differential immunohistological features of inflammatory myopathies and dysferlinopathy
    Jae Hwan Choi
    Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea
    J Korean Med Sci 24:1015-23. 2009
    ..The analysis of inflammatory cells, MHC class I expressions and MAC deposits may help to differentiate dysferlinopathy from idiopathic inflammatory myopathy...
  51. ncbi Human muscle protein degradation in vitro by eosinophil cationic protein (ECP)
    R Sugihara
    Third Department of Internal Medicine, Oita Medical University, Hasama 1-1, Oita 879-5593, Japan
    Muscle Nerve 24:1627-34. 2001
    ..that tissue eosinophils have a specific role in muscle fiber degradation in some myopathies associated with numerous tissue eosinophils, such as eosinophilic myositis, eosinophilic myalgia syndrome, and eosinophilic endocardial disease.
  52. pmc Myositis-related interstitial lung disease and antisynthetase syndrome
    Joshua Solomon
    Interstitial Lung Disease Program, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    J Bras Pneumol 37:100-9. 2011
    In patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies marks the presence or predicts the development of interstitial lung disease (ILD)...
  53. ncbi Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis
    Ali Zaid
    University of Canberra, Canberra, Australian Capital Territory, Australia
    Arthritis Rheum 63:488-91. 2011
    ..This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease...
  54. ncbi Benign acute myositis associated with H1N1 influenza A virus infection
    Esther Rubín
    Department of Pediatrics, Marques de Valdecilla Hospital, University of Cantabria, 39008 Santander, Cantabria, Spain
    Eur J Pediatr 169:1159-61. 2010
    We report the clinical and laboratory features of four children with benign acute myositis observed during the current outbreak of the novel H1N1 influenza A virus...
  55. ncbi A large outbreak of influenza B-associated benign acute childhood myositis in Germany, 2007/2008
    Sabine Mall
    NRW Institute of Health and Work, Centre for Public Health, Muenster, Germany
    Pediatr Infect Dis J 30:e142-6. 2011
    Benign acute childhood myositis (BACM) is a rare syndrome associated with various viral infections. Bilateral calve pain may lead to inability to walk...
  56. ncbi Beta-chemokine receptor expression in idiopathic inflammatory myopathies
    Boel De Paepe
    Department of Neurology, Neuromuscular Laboratory, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Muscle Nerve 31:621-7. 2005
    ..We studied the distribution of beta-chemokine receptors in polymyositis (PM), sporadic inclusion-body myositis (sIBM), dermatomyositis (DM), and control samples. CCR1-5 were localized to blood vessels in all samples...
  57. ncbi Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease
    I N Targoff
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City
    Arthritis Rheum 35:821-30. 1992
    ..describe the clinical associations of the antibody, in particular, whether it is associated with the syndrome of myositis and interstitial lung disease (ILD) that has been previously associated with autoantibodies to the aminoacyl-tRNA ..
  58. ncbi Necrotizing myositis and septic shock caused by Haemophilus influenzae type f in a previously healthy man diagnosed with an IgG3 and a mannose-binding lectin deficiency
    Fredrik Resman
    Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skane University Hospital, SE 20502 Malmo, Sweden
    Scand J Infect Dis 43:972-6. 2011
    ..We present here a dramatic case of Hif necrotizing myositis and septic shock...
  59. ncbi High frequencies and co-existing of myositis-specific autoantibodies in patients with idiopathic inflammatory myopathies overlapped to rheumatoid arthritis
    Ayako Nakajima
    Institute of Rheumatology and Aoyama Hospital, Tokyo Women s Medical University, 10 22 Kawada cho, 162 0054 Shinjuku ku, Tokyo, Japan
    Rheumatol Int 32:2057-61. 2012
    ..Clinical and laboratory data, including autoantibody test results, were collected from patient medical records. Myositis-specific antibodies (MSAs) were analyzed by immunoprecipitation...
  60. ncbi Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients
    Yves Troyanov
    Division of Rheumatology, Department of Medicine, Centre Hospitalier, Universite de Montreal, Faculty of Medicine, Montreal, Quebec, Canada
    Medicine (Baltimore) 84:231-49. 2005
    ..significance to the presence of overlap features, that is, their presence resulted in a diagnosis of overlap myositis (OM). This approach allowed direct comparison with the original Bohan and Peter classification...
  61. pmc The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis
    D L Defosse
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
    Am J Pathol 141:3-10. 1992
    ..burgdorferi resulting in pancarditis, synovitis, and skeletal interstitial myositis whereas controls remained normal...
  62. ncbi Review article: the gastrointestinal complications of myositis
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Aliment Pharmacol Ther 31:359-65. 2010
    ..The three major diseases are dermatomyositis, polymyositis and inclusion body myositis.
  63. pmc Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
    J Exp Med 196:781-91. 2002
    ..aminoacyl-tRNA synthetases, perhaps liberated from damaged muscle cells, may perpetuate the development of myositis by recruiting mononuclear cells that induce innate and adaptive immune responses...
  64. ncbi VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model
    Christoph Spang
    Section for Anatomy, Department of Integrative Medical Biology, Umea University, 901 87, Umea, Sweden
    Inflammation 35:39-48. 2012
    It is not known whether a glutamate signaling system is involved in muscle inflammation (myositis)...
  65. pmc Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis
    Lara J Herrero
    Virus and Inflammation Research Group, Faculty of Applied Science, University of Canberra, Canberra, ACT 2601, Australia
    Proc Natl Acad Sci U S A 108:12048-53. 2011
    ..The prospect being that early treatment with MIF-blocking pharmaceuticals may curtail the debilitating arthritis associated with alphaviral infections...
  66. pmc Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
    J Virol 78:10320-7. 2004
    ..spastic paraparesis (HAM/TSP), concomitantly with or without other inflammatory disorders such as myositis. These pathologies are considered immune-mediated diseases, and it is assumed that migration within tissues of ..
  67. ncbi Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
    Cecilia Grundtman
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    FASEB J 24:570-8. 2010
    ..However, HMGB1-expressing fibers outnumbered fibers expressing MHC class I. Our data indicate that HMGB1 could be an early inducer of skeletal muscle dysfunction in IIMs...
  68. ncbi Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior
    R Ambalavanar
    Department of Biomedical Sciences and Program in Neuroscience, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 143:875-84. 2006
    ..The present data support the hypothesis that CGRP is upregulated during deep tissue inflammation and suggest that gene transcription is involved in this upregulation...
  69. pmc Tropical pyomyositis (myositis tropicans): current perspective
    S Chauhan
    Department of Internal Medicine, PGIMER, Chandigarh, India
    Postgrad Med J 80:267-70. 2004
    ..Treatment for Gram negative or anaerobic organisms should be instituted, whenever indicated. Physicians should become more familiar with this potentially life threatening but curable infective disease entity...
  70. ncbi Identification of activated cytokine pathways in the blood of systemic lupus erythematosus, myositis, rheumatoid arthritis, and scleroderma patients
    Brandon W Higgs
    Translational Sciences, MedImmune, LLC, Gaithersburg, MD 20878, USA
    Int J Rheum Dis 15:25-35. 2012
    ....
  71. ncbi Acute pure motor quadriplegia: is it dengue myositis?
    J Kalita
    Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India
    Electromyogr Clin Neurophysiol 45:357-61. 2005
    ..In view of paucity of comprehensive evaluation about dengue infection producing quadriplegia, we report the clinical, laboratory and neurophysiological studies in these patients...
  72. pmc Tubulinosema sp. microsporidian myositis in immunosuppressed patient
    Maria M Choudhary
    Cleveland Clinic Foundation, Department of Internal Medicine, 9500 Euclid Foundation, NA10, Cleveland, OH 44195, USA
    Emerg Infect Dis 17:1727-30. 2011
    ..We report an infection by Tubulinosema sp. in an immunosuppressed patient...
  73. pmc The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage
    Heather M Alger
    Children s National Medical Center and George Washington University Medical Center, Washington, DC, USA
    Arthritis Rheum 63:3448-57. 2011
    ..cells are relatively resistant to classic apoptosis, and the factors initiating cell death and damage in myositis are not well defined. We hypothesized that nonimmune autophagic cell death may play a role in muscle fiber damage...
  74. ncbi International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease
    D A Isenberg
    Center for Rheumatology, Department of Medicine, The Middlesex Hospital, University College London, London, UK
    Rheumatology (Oxford) 43:49-54. 2004
    ..To devise new tools to assess activity and damage in patients with idiopathic myopathies (IIM)...
  75. ncbi HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:3670-81. 2006
    ..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM...
  76. pmc The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis
    Hector Chinoy
    Rheumatic Diseases Centre, Hope Hospital, The University of Manchester, Salford, UK
    Ann Rheum Dis 66:1345-9. 2007
    There is a known association between myositis and cancer. The risk is greater in dermatomyositis (DM) than polymyositis (PM), although reliable methods to predict cancer risk in specific patients with myositis are not presently available...
  77. ncbi Influenza myocarditis and myositis: case presentation and review of the literature
    Kanwal Kumar
    Institute of Cardiovascular Sciences, St Boniface Research Centre, Winnipeg, Manitoba, Canada
    Can J Cardiol 27:514-22. 2011
    ..Despite common pathogens, concomitant myocarditis and myositis remains a rare event...
  78. ncbi Clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy
    L G Rider
    Center for Biologics Evaluation and Research, FDA, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:710-9. 1998
    ..To describe the clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy (IIM) and to compare these with the features of sporadic IIM...
  79. ncbi Trachipleistophora hominis infection in the myocardium and skeletal muscle of a patient with AIDS
    A Curry
    Health Protection Agency, Manchester Royal Infirmary, Clinical Sciences Building, Oxford Road, Manchester M13 9WL, UK
    J Infect 51:e139-44. 2005
    ..To review the literature relevant to microsporidial infection of muscle and to describe a case of human microsporidial infection involving both skeletal and cardiac muscle...
  80. ncbi An update on the immunogenetics of idiopathic inflammatory myopathies: major histocompatibility complex and beyond
    Hector Chinoy
    The University of Manchester Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Salford, UK
    Curr Opin Rheumatol 21:588-93. 2009
    ..To update the reader on immunogenetic advances in idiopathic inflammatory myopathy (IIM) over the past 18 months...
  81. pmc Myopathy with antibodies to the signal recognition particle: clinical and pathological features
    T Miller
    Washington University School of Medicine, Department of Neurology, St Louis, Missouri 63110, USA
    J Neurol Neurosurg Psychiatry 73:420-8. 2002
    To study myopathies with serum antibodies to the signal recognition particle (SRP), an unusual, myositis specific antibody associated syndrome that has not been well characterised pathologically.
  82. pmc Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen
    Christina M Coyle
    Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA
    N Engl J Med 351:42-7. 2004
  83. pmc Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies
    Masahiro Kondo
    Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
    Immunology 128:e589-99. 2009
    ....
  84. ncbi Acute dengue virus myositis: a report of seven patients of varying clinical severity including two cases with severe fulminant myositis
    Vimal Kumar Paliwal
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Neurol Sci 300:14-8. 2011
    Acute dengue myositis is characterized by fever and myalgia (with or without muscle weakness).
  85. ncbi MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm
    Michele Gaeta
    Department of Radiological Sciences, University of Messina, AOU Policlinico G Martino, Messina, Italy
    Skeletal Radiol 38:571-8. 2009
    The authors describe magnetic resonance (MR) findings in eight patients with histologically confirmed focal myositis.
  86. ncbi Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression
    Harsha Gunawardena
    Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 48:607-12. 2009
    ..Over the last few years, myositis-specific autoantibodies (MSAs) have been better characterized including autoantibodies directed against the ..
  87. ncbi HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy
    Hector Chinoy
    Centre for Integrated Genomic Medical Research, University of Manchester, UK
    Rheumatology (Oxford) 48:1213-7. 2009
    ..The HLA-DPB1 gene is centromeric to other HLA class II loci and separated by a recombination hotspot. We investigated whether HLA-DPB1 associations differ between anti-Jo-1 and anti-PM-Scl antibody-positive IIM cases...
  88. ncbi Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay
    Anna Ghirardello
    Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Rheumatology (Oxford) 49:2370-4. 2010
    Serological testing for myositis-specific or associated autoantibodies [myositis-specific antibody (MSA) and myositis-associated antibody (MAA)] is useful for the diagnosis of idiopathic inflammatory myopathies (IIMs)...
  89. ncbi Inflammatory myopathies: evaluation and management
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women sHospital, and Harvard Medical School, Boston, MA 02115, USA
    Semin Neurol 28:241-9. 2008
    The inflammatory myopathies, including dermatomyositis, inclusion body myositis, and polymyositis, are poorly understood autoimmune diseases affecting skeletal muscle...
  90. ncbi Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians
    Terrance P O'Hanlon
    National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
    Medicine (Baltimore) 84:338-49. 2005
    ..were exclusive protective factors for the CD8+ T cell-mediated IIM forms of polymyositis (PM) and inclusion body myositis (IBM) (pc < 0.005)...
  91. ncbi Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins
    Nestor E Rulli
    Faculty of Applied Science, University of Canberra, Canberra, ACT, Australia
    Arthritis Rheum 60:2513-23. 2009
    ..The aim of the present investigations was to determine whether bindarit, an inhibitor of monocyte chemotactic protein (MCP) synthesis, could ameliorate alphavirus-induced rheumatic disease in mice...
  92. ncbi Proteomic analysis of inclusion body myositis
    Jie Li
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Neuropathol Exp Neurol 65:826-33. 2006
    Sporadic inclusion body myositis (IBM) is the most frequently acquired inflammatory myopathy of late adult life, yet its diagnostic criteria and pathogenesis remain poorly defined...
  93. ncbi A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies
    Maija Leena Eloranta
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:3112-24. 2007
    To investigate type I interferon (IFN) system activation and its correlation with autoantibodies and organ manifestations in polymyositis (PM), dermatomyositis (DM), and inclusion body myositis.
  94. ncbi Anti-Jo-1 antibody levels correlate with disease activity in idiopathic inflammatory myopathy
    Kerry B Stone
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 56:3125-31. 2007
    Previous case series have examined the relationship between anti-Jo-1 antibody levels and myositis disease activity, demonstrating equivocal results...
  95. ncbi Defining Clinical Improvement in Adult and Juvenile Myositis
    Lisa G Rider
    Enviromental Autoimmunity Group, National Institute of Enviromental Health Sciences, National Institutes of Health, Bethesda, MD 20892, USA
    J Rheumatol 30:603-17. 2003
    ..rehabilitation medicine physicians, statisticians, and patient support group leaders, called the International Myositis Outcome Assessment Collaborative Study Group (IMACS), is engaged in developing consensus on the assessment of ..
  96. ncbi Inflammatory muscle diseases: a critical review on pathogenesis and therapies
    Marinos C Dalakas
    Department of Neurosciences, Imperial College, London, UK
    Curr Opin Pharmacol 10:346-52. 2010
    ..the most common immune inflammatory muscle disorders include Dermatomyositis (DM), Polymyositis (PM), Necrotizing Myositis (NM), and sporadic Inclusion Body Myositis (sIBM)...
  97. ncbi West Nile virus encephalitis with myositis and orchitis
    Roger D Smith
    Department of Pathology and Laboratory Medicine, Universityof Cincinnati Medical Center, OH 45267 0529, USA
    Hum Pathol 35:254-8. 2004
    ..Extra-CNS findings include myositis with T-lymphocyte infiltration of nerve fibers, suggesting that the virus may reach the CNS via peripheral nerves...
  98. pmc A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy
    Lisa Christopher-Stine
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 62:2757-66. 2010
    ..The aim of this study was to identify novel autoantibodies in patients with necrotizing myopathy...
  99. pmc Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis
    Charles Kwok chong Li
    Rheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Am J Pathol 175:1030-40. 2009
    ..Overexpression of MHC class I protein is a common feature of many muscle pathologies including idiopathic myositis and can induce ER stress...
  100. ncbi Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfalls
    Ane Labirua
    Internal Medicine Department, Vall d Hebron General Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr Opin Rheumatol 22:633-8. 2010
    ..To present the latest findings regarding interstitial lung disease (ILD) in idiopathic inflammatory myopathies, focusing on the phenotype of ILD and auto-antibodies, pathogenesis and treatment...
  101. ncbi Clinical and serological characteristics of 125 Dutch myositis patients. Myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathies
    G J D Hengstman
    Neuromuscular Centre Nijmegen, Institute of Neurology, University Medical Centre Nijmegen, The Netherlands
    J Neurol 249:69-75. 2002
    ..that include the familiar disease entities of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM)...

Research Grants63

  1. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
  2. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
  3. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..This program will help the Candidate to train and develop scientists interested in drug development in academic settings. These efforts in the long term will help us to develop specific drugs for inflammatory diseases. ..
  4. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..connective tissues supporting the dentition (gingivitis and periodontitis), muscles involved in mastication (myositis), or temporomandibular joint (arthritis or temporomandibular disorder/TMD)...
  5. Acquisition of a TIRF/Widefield fluorescence microscope for cell biology and neur
    Bryon D Grove; Fiscal Year: 2013
    ..of North Dakota including Alzheimers[unreadable] disease, Parkinson[unreadable]s disease, inclusion body myositis (IBM), epilepsy and many more...
  6. Functional impact of dendritic cell phenotype in a mouse model of myositis
    Dana P Ascherman; Fiscal Year: 2010
    ..The latter objective is relevant to the treatment of multiple autoimmune diseases for which global immunosuppression is the only therapeutic option. ..
  7. Role of Presenilin in Idiopathic Dilated Cardiomyopathy
    Federica Del Monte; Fiscal Year: 2013
    ..such as primary systemic amyloidosis, diabetes, cystic fibrosis, neurodegenerative diseases and inclusion body myositis. Although the molecular mechanisms by which these pathologies develop might be different, they are recently been ..
  8. Contribution of catabolite control protein A to group A streptococcal virulence
    Samuel A Shelburne; Fiscal Year: 2013
    ..GAS gene expression during infection in mouse muscle;2) Inactivation of CcpA decreased GAS virulence in a mouse myositis model;3) Mutation of the central CpG of a GAS cre site decreased CcpA-(HPr-Ser46-P) DNA binding affinity;and 4) ..
  9. The Role of IL-17 Axis in Inflammatory Myositis
    Ann M Reed; Fiscal Year: 2013
    ..of uncommon but life- and organ-threatening autoimmune syndromes collectively known as idiopathic inflammatory myositis (IIM). Patients with DM suffer debilitating muscle weakness, respiratory impairment, and disfiguring skin rashes...
  10. A device for rapid, painless, bedside muscle evaluation of children
    JOSE LUIS BOHORQUEZ; Fiscal Year: 2012
    ..Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and inflammatory myositis, and affect well over 100,000 children in the United States alone...
  11. Post-9/11 Incidence of Systemic Autoimmune Diseases in the FDNY Cohort
    Mayris P Webber; Fiscal Year: 2013
    ..SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc;both diffuse and limited), inflammatory myositis (dermatomyositis, polymyositis, or inclusion-body myositis), Sjogren's syndrome, rheumatoid arthritis (RA), ..
  12. Multiparametric Classification of Muscle Damage in Inflammatory Myopathy
    Jane Park; Fiscal Year: 2013
    ..idiopathic inflammatory myopathies (IIM), including dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM), are autoimmune diseases resulting in muscle inflammation, weakness, and pain...
  13. Pathogenesis of Arthritis and Myositis-Associated Alphaviruses
    Thomas E Morrison; Fiscal Year: 2010
    ..Relevance: Arthritis/myositis-associated alphaviruses are an emerging threat due to their ability to initiate explosive epidemics and to cause ..
  14. Rituximab Therapy in Refractory Adult and Juvenile IIM
    CHARLES ODDIS; Fiscal Year: 2010
    ..It has also been studied and used in small numbers of patients with myositis. This study will evaluate the efficacy of rituximab in treating refractory adult and pediatric patients with ..
  15. Rituximab Therapy in Refractory Adult and Juvenile IIM
    CHARLES ODDIS; Fiscal Year: 2009
    ..It has also been studied and used in small numbers of patients with myositis. This study will evaluate the efficacy of rituximab in treating refractory adult and pediatric patients with ..
  16. TRIM Interactions with Arthritic Alphaviruses
    Mark T Heise; Fiscal Year: 2013
    ..such as Chikungunya virus (CHIKV) and Ross River virus (RRV) cause severe acute and persistent arthritis and myositis in infected humans and are significant emerging disease threats...
  17. Structural insight into the role of CHD4 PHD fingers.
    CATHERINE ANNE MUSSELMAN; Fiscal Year: 2011
    Human CHD4 (chromodomain helicase DMA-binding protein 4) is an autoantigen of myositis, an autoimmune disease associated with an increased risk of conjestive heart failure, arrhythmia, myocardial infarction and cardiac arrest...
  18. Discovery of Novel Autoantigens in Patients with Inclusion Body Myositis
    KEVIN C O'CONNOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness...
  19. Eosinophils support nematode infection
    Judith A Appleton; Fiscal Year: 2012
    ..We have discovered that eosinophils contribute to the ensuing myositis while simultaneously protecting larvae against immune-mediated destruction...
  20. Rheumatic Disease Sera: Probes of Disease Mechanisms
    Livia A Casciola-Rosen; Fiscal Year: 2012
    ..Recent studies have demonstrated that autoantigens in myositis are expressed at high levels in inflamed muscle, particularly in regenerating muscle cells...
  21. Role of RyRs, DHPRs and Ca2+ Entry in the Inclusion Body Myositis
    Alexander Shtifman; Fiscal Year: 2010
    ..proteins on Ca2+ dysregulation in skeletal muscle as it relates to a skeletal muscle disorder, the Inclusion Body Myositis (IBM). Dr...
  22. Characterization of Autoreactivity to Muscle Proteins in Inclusion Body Myositis
    Mohammad Salajegheh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is a common inflammatory myopathy of the elderly...
  23. A Multidisciplinary Analysis of Gelsolin Amyloid Disease
    Jeffery W Kelly; Fiscal Year: 2010
    ..many features of FAF pathology, including the intracellular inclusions also associated with inclusion body myositis (IBM), the most common muscle degenerative disease in the aging population...
  24. Screening for drug targets in a Drosophila model of muscle degeneration
    EDWARD KWAME OWUSU ANSAH; Fiscal Year: 2010
    ..e. the dystrophin model, parkin/pinkl model and a sporadic inclusion-body myositis model) to identify several muscle pan-degeneration markers...
  25. Pathogenesis of autoimmune myositis: Role of MHC Class 1
    Kanneboyina Nagaraju; Fiscal Year: 2009
    ..The MHC class 1 mouse model of myositis is a powerful tool to identify such pathways...
  26. Eosinophils sustain chronic nematode infection
    Judith A Appleton; Fiscal Year: 2010
    ..We have discovered that eosinophils contribute to the ensuing myositis while simultaneously promoting protection of larvae against immune-mediated destruction...
  27. Persistent chikungunya virus infection and disease
    Thomas E Morrison; Fiscal Year: 2012
    ..We have developed a mouse model of CHIKV infection in which the major pathological outcomes, arthritis, myositis, and tenosynovitis, are consistent with the clinical signs experienced by the majority of CHIKV-infected humans...
  28. Idiopathic Inflammatory Myopathies: Improving Diagnosis and Predicting Outcomes
    Lisa Christopher Stine; Fiscal Year: 2010
    ..Allan Gelber, Antony Rosen, and Paul Plotz. IIM, including dermatomyositis, polymyositis, and inclusion body myositis, constitute the largest subset of acquired myopathies and often affect adults in their prime...
  29. The role of the dermatomyositis autoantigen MI-2 in muscle regeneration
    ANDREW L MAMMEN; Fiscal Year: 2012
    ..Recent data show low levels of myositis autoantigens (including Mi-2, a chromatin remodeling enzyme) in normal muscle...
  30. Naturally Occurring Dog Model for Juvenile Dermatomyositis
    Leigh Anne Clark; Fiscal Year: 2013
    ..This approach is innovative because it utilizes a naturally occurring dog model of disease to better understand the complex genetic factors that contribute to DM. ..
  31. Sialic acid has putative signaling roles in muscle disorders of aging
    Nam Pham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease associated with aging. sIBM afflicts individuals older than 50 years of age...
  32. Innate immune and metabolic pathway interactions in myositis
    TRAVIS KINDER; Fiscal Year: 2013
    ..applicant): Skeletal muscle inflammation of unknown cause is referred to as idiopathic inflammatory myopathy, or myositis. Muscle weakness is one of the characteristic features of such disease conditions...
  33. Mechanisms of Response and Relapse in Rituximab-treated Myositis Patients
    Chester V Oddis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autoimmune (AI) inflammatory muscle diseases (myositis) include polymyositis (PM), adult dermatomyositis (DM) and juvenile dermatomyositis (JDM)...
  34. Functional Interactions Between Peripheral P2X3 and TRP Channels
    JAMI LYNN SALOMAN; Fiscal Year: 2012
    ..The identification of new mechanisms underlying mechanical hyperalgesia during myositis conditions could contribute to alternative treatment strategies for the management of TMD and other muscle pain ..
  35. Treatment Strategies for Neuromuscular Diseases: The Challenge of Recruitment
    Robert C Griggs; Fiscal Year: 2010
    ....
  36. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    Trichinella spiralis is an intracellular nematode parasite of mammalian skeletal muscle cells that causes severe myositis and, sometimes, death in humans...
  37. TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    Frank LaFerla; Fiscal Year: 2001
    ..overall long-term objective of this FIRST proposal is to understand the molecular pathogenesis of inclusion body myositis (IBM), the most common muscle disease in personals over 50 years of age...
  38. MITOCHONDRIAL DNA DEPLETION IN HUMAN DISEASE
    Tuan Vu; Fiscal Year: 2000
    ..such as autosomal dominant progressive external ophthalmoplegia with multiple deletions and inclusion-body myositis. Although the mechanisms leading to mtDNA depletion in these disorders are unknown, this type of depletion is ..
  39. Polyamine based Therapy of E. bieneusi Infected Mice
    VENUDHAR REDDY; Fiscal Year: 2006
    ..common manifestation is gastrointestinal tract infection; however, encephalitis, ocular infection, sinusitis, myositis and disseminated infection are reported...
  40. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
    ..We and others have developed a mouse model of RRV-induced arthritis and myositis, where the virus replicates to high levels in the synovial joints and skeletal muscle, but virus induced disease ..
  41. Beta-Amyloid & Cell Death Mechanisms in Skeletal Muscle
    Henry Querfurth; Fiscal Year: 2005
    DESCRIPTION (Adapted from applicant's abstract): Inclusion Body Myositis (IBM) is the most common muscle disorder in patients over 50 years of age...
  42. Alzheimer Vaccines: Noninvasive Vaccination by DNA-Base*
    Ken Ichiro Fukuchi; Fiscal Year: 2005
    Alzheimer's disease (AD) and inclusion-body myositis (IBM) are the most common degenerative diseases in brain and skeletal muscle, respectively, in people over age 50 years...
  43. HLA RELATIONSHIPS OF PREGNANCY, CHIMERISM & AUTOIMMUNITY
    J Nelson; Fiscal Year: 1999
    ..and have clinical features in common with some human autoimmune disease such as scleroderma, Sjogren's syndrome, myositis, primary biliary cirrhosis and systemic lupus erythematosus (SLE)...
  44. MULTIPURPOSE ARTHRITIS CENTER
    Charles Christian; Fiscal Year: 1980
    ..Seven patients with myositis and serologic evidence of recent toxoplasmodis have been studied in assays of cellular immunity...
  45. IMMUNOPATHIC MYOSITIS INDUCED BY PERSISTENT VIRUS
    Ronald Messner; Fiscal Year: 2002
    ..Focused, mechanistic hypotheses can then be developed to explore these interactions in future studies. ..
  46. Viral dsRNA as a Mediator of Chronic Muscle Diseases
    PATRICIA TAM; Fiscal Year: 2005
    ..The results will advance the development of better tools for the epidemiologic study, diagnosis, and treatment of diseases where enterovirus infection has been implicated. ..
  47. Modulating IBM pathology in transgenic mice
    Frank LaFerla; Fiscal Year: 2005
    ..to develop and characterize novel transgenic mouse models to study the molecular pathogenesis of inclusion body myositis (IBM)...
  48. Skin-patch Vaccination against Alzheimer's Disease
    Ken Ichiro Fukuchi; Fiscal Year: 2002
    Alzheimer's disease (AD) and inclusion body myositis (IBM) share a number of common pathologies such as deposits of amyloid beta-protein (AB) and paired helical filaments, although such pathologies are mostly restricted to brain for AD ..
  49. Finalization of Outcomes and Design Issues for Myositis
    Ann Reed; Fiscal Year: 2001
    ..This study will develop the validated outcome measures needed and set the stage to allow for the successful completion of large multicenter trials in the Idiopathic Inflammatory myopathies. ..
  50. ECTOPIC EXPRESSION OF THE PRION PROTEIN
    Patrick Bosque; Fiscal Year: 1999
    ..in these animals may also demonstrate similarities between the mechanism of prion disease and inclusion body myositis or type Il diabetes mellitus. If so, these animals may serve as models of these conditions...
  51. MAMDC--UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE
    David Glass; Fiscal Year: 2000
    ..H. Giannini, MSc, DrPH 2) Molecular Genotyping and Sequencing; -S.D. Thompson, PhD Establishment of the MAMDC will promote innovative approaches to laboratory an clinical research. ..
  52. RNA Polymerase Sigma Factors in Streptococcus pyogenes
    CHARLES MORAN; Fiscal Year: 2005
    ..acute glomerulonephritis, and possibly pediatric neuropsychological disorders, to severe invasive diseases like myositis and streptococcal toxic shock syndrome...
  53. IMMUNOPATHOGENESIS OF EXPERIMENTAL ALLERGIC MYOSITIS
    Abdolmohamad Rostami; Fiscal Year: 1993
    ..Experimental allergic myositis (EAM) is a useful animal model for human polymyositis...
  54. PLANNING GRANT FOR A MULTIPURPOSE CLINICAL RES CENTER
    Morris Reichlin; Fiscal Year: 1999
    ..is to promote high quality clinical research in systemic lupus erythematosus, rheumatoid arthritis, inflammatory myositis and Wegener's granulomatosus...
  55. Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
    Lauren Pachman; Fiscal Year: 2006
    ..Specific Aim 3 will characterize the gene expression profiles in JDM as well as children with myositis related antibodies, who have nonremittent disease...
  56. Dermatomyositis Skin Disease Severity Measure Validation
    JOSPEH JORIZZO; Fiscal Year: 2003
    ..abstract_text> ..
  57. Proteomic Studies in Inclusion Body Myositis
    Steven Greenberg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Inclusion body myositis (IBM) is a disease of unknown cause characterized by slowly progressive painless weakness and with no effective treatment...
  58. Injured Muscle: Effect on Neutrophil Function
    FRANCIS PIZZA; Fiscal Year: 2003
    ....
  59. Role of RyRs and DHPRs and Ca2+ Entry in beta-amyloid mediated Ca2+ dysregulation
    Alexander Shtifman; Fiscal Year: 2009
    ..clinical scientist with extensive experience in adenoviral gene delivery and in the field of the Inclusion Body Myositis (IBM) and Dr. Lopez, who is an independent scientist with extensive experience in microelectrode recordings...
  60. AAA ATPase p97/VCP and Inclusion Body Myopathy
    CONRAD WEIHL; Fiscal Year: 2009
    ..to investigate the cellular mechanisms of aging in relation to skeletal muscle disorders, using inclusion body myositis (IBM) as a prototypical disease. The mentored scientific training will be performed jointly in the labs of Drs...
  61. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  62. MECHANISMS OF COXASACKIEVIRUS INDUCED POLYMYOSITIS
    Ronald Messner; Fiscal Year: 1992
    ..The results of these experiments should provide important information that will enhance our understanding of the mechanism through which CVB1 induces an immunologically mediated myositis.