Genomes and Genes
Summary: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)
Publications278 found, 100 shown here
- Musculoskeletal ultrasound including definitions for ultrasonographic pathologyRichard J Wakefield
Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
J Rheumatol 32:2485-7. 2005Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy...
- The role of synovitis in pathophysiology and clinical symptoms of osteoarthritisJeremie Sellam
Pierre and Marie Curie University, Department of Rheumatology, AP HP Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, Paris 75012, France
Nat Rev Rheumatol 6:625-35. 2010..breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain...
- 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiativeDaniel Aletaha
Arthritis Research UK, Copeman House, Chesterfield, UK
Ann Rheum Dis 69:1580-8. 2010..This work was undertaken to develop new classification criteria for RA...
- The role of synovitis in osteoarthritis pathogenesisCarla R Scanzello
Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
Bone 51:249-57. 2012..The histological changes observed in the SM in OA generally include features indicative of an inflammatory "synovitis"; specifically they encompass a range of abnormalities, such as synovial lining hyperplasia, infiltration of ..
- Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patientsM Chemel
INSERM, UMR 957, France
Ann Rheum Dis 71:150-4. 2012..Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA)...
- Synovitis score: discrimination between chronic low-grade and high-grade synovitisV Krenn
Institute for Pathology, Trier, and Department for Rheumatology, Charite University Hospital, Berlin, Germany
Histopathology 49:358-64. 2006..To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases...
- Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohortMohammed Z Cader
Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
Ann Rheum Dis 70:949-55. 2011..This study therefore assesses the performance of these new criteria in patients with early synovitis.
- Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot studyD Baeten
Department of Rheumatology, Ghent University, Belgium
Arthritis Rheum 44:186-95. 2001..on synovial histology in patients with spondylarthropathy (SpA) in order to confirm the effect on peripheral synovitis and to investigate the immunologic mechanisms involved in anti-TNFalpha therapy...
- Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imagingYuqing Zhang
Boston University School of Medicine, Boston, Massachusetts 02118, USA
Arthritis Rheum 63:691-9. 2011..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
- OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring systemMikkel Østergaard
Danish Research Center of Magnetic Resonance and Department of Rheumatology at the Copenhagen University Hospital at Hvidovre, Denmark
J Rheumatol 30:1385-6. 2003..MRI definitions of important RA joint pathologies, and a "core set" of basic MRI sequences for use in RA are also suggested...
- Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitisAntonio Manzo
Rheumatology Unit, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, UK
Eur J Immunol 35:1347-59. 2005..we analyzed the relationship between CXCL13 and CCL21 production and lymphoid tissue organization in rheumatoid synovitis as a model of a naturally occurring ectopic lymphoneogenesis...
- Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritisFiona M McQueen
Auckland District Health Board and Auckland University, Auckland, New Zealand
Arthritis Rheum 48:1814-27. 2003Magnetic resonance imaging (MRI) is capable of revealing synovitis and tendinitis in early rheumatoid arthritis (RA), as well as bone edema and erosion. These features are visible before radiographic joint damage occurs...
- Power Doppler ultrasound assessment of rheumatoid hand synovitisM Stone
Department of Rheumatology, Mater Misericordiae Hospital, Dublin, Ireland
J Rheumatol 28:1979-82. 2001..power Doppler ultrasound (PD) as a technique in assessing response to treatment with steroids in rheumatoid hand synovitis. METHODS: Twelve patients with rheumatoid hand synovitis were assessed before and after treatment with steroids...
- Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritisM Walther
University of Wuerzburg, Germany
Arthritis Rheum 44:331-8. 2001..01). CONCLUSION: In the present study, PDS proved to be a reliable diagnostic method for qualitative grading of the vascularity of the synovial tissue. In clinical practice, PDS allows further differentiation of the hypertrophic synovium...
- Pre-rheumatoid arthritis: predisposition and transition to clinical synovitisWilliam P Arend
Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA william arend ucdenver edu
Nat Rev Rheumatol 8:573-86. 2012..Subsequent engagement of Fc receptors and complement activation would lead to secondary inflammation in the synovium with induction of a perpetuating cycle of chronic synovitis.
- Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritisPhilip G Conaghan
University of Leeds and Leeds General Infirmary, Leeds, UK
Arthritis Rheum 48:64-71. 2003..To simultaneously image bone and synovium in the individual joints characteristically involved in early rheumatoid arthritis (RA)...
- In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitisGarifallia Sakellariou
IRCCS Fondazione Policlinico San Matteo, Piazzale Golgi, Pavia 27100, Italy
Ann Rheum Dis 72:245-9. 2013..Rheumatology/European League Against Rheumatism (ACR/EULAR) and disease activity score in 44 and 28 joints (DAS, DAS28) definitions of remission in early rheumatoid arthritis (RA), against disability and ultrasound-detectable synovitis.
- A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritisAlexander K Scheel
Georg August University Gottingen, Germany
Arthritis Rheum 52:733-43. 2005To develop an ultrasonographic (US) synovitis scoring system suitable for evaluation of finger joint inflammation in patients with active rheumatoid arthritis (RA) and to compare semiquantitative US scoring with quantitative US ..
- Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patientsX Ayral
Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
Osteoarthritis Cartilage 13:361-7. 2005To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage.
- Lymphoid neogenesis in rheumatoid synovitisS Takemura
Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Immunol 167:1072-80. 2001....
- Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progressionA K Brown
Chapel Allerton Hospital, University of Leeds, Leeds, UK
Arthritis Rheum 54:3761-73. 2006..This questions the validity of current methods of assessing remission in RA. The purpose of this study was to test the hypothesis that modern joint imaging improves the accuracy of remission measurement in RA...
- Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonographyAntonio Manzo
Division of Rheumatology, Laboratory of Rheumatology, University of Pavia School of Medicine and IRCCS Policlinico San Matteo Foundation, P le Golgi 2, 27100 Pavia, Italy
Rheumatology (Oxford) 50:1395-400. 2011..To investigate the suitability of power Doppler ultrasonography (PD-US) for the assessment of lymph node (LN) status in RA, evaluating the existence of structural and dynamic modifications in well-characterized stages of the disease...
- Expression of aquaporin 1 (AQP1) in human synovitisAli Mobasheri
Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Sutton Bonington LE12 5RD, UK
Ann Anat 192:116-21. 2010Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial proliferation (synovitis), articular cartilage and subchondral bone degradation as well as joint swelling...
- Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitisA Price
University of Paisley, Paisley, UK
Arthritis Rheum 56:441-7. 2007..The purpose of this study was to investigate the antiinflammatory potential of the selective AT(1) receptor antagonist losartan, which is currently used for the treatment of cardiovascular disease...
- Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitisCarmen A Ambarus
Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Arthritis Res Ther 14:R74. 2012..Here, we aimed to evaluate the polarization status of synovial macrophages in spondyloarthritis (SpA) and rheumatoid arthritis (RA)...
- Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomographyConny J van der Laken
VU University Medical Center, Amsterdam, The Netherlands
Arthritis Rheum 58:3350-5. 2008..We undertook this study to investigate whether rheumatoid synovitis can be visualized by PET using the tracer 11C-(R)-PK11195, which binds to peripheral benzodiazepine receptors (..
- Blau syndrome, clinical and genetic aspectsPaolo Sfriso
Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy
Autoimmun Rev 12:44-51. 2012..Clinical and genetic aspects of the familial and the sporadic form of BS will be discussed and focused on. A description of a case study of an Italian family is also included...
- The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cellsKeisuke Maeshima
University of Occupational and Environmental Health, Japan
Arthritis Rheum 64:1790-8. 2012..The aim of this study was to examine the effects of tofacitinib in vitro and in vivo in RA, in order to elucidate the role of JAK in the disease process...
- Rheumatoid arthritis: from autoimmunity to synovitis and joint destructionMarie Christophe Boissier
Université Sorbonne Paris Cité, Universite Paris 13, Li2P, EA4222 Bobigny, France
J Autoimmun 39:222-8. 2012....
- EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritisM A D'Agostino
Rheumatology Department, Cochin Hospital, Paris, France
Ann Rheum Dis 64:1703-9. 2005..of inflammation in subjects with chronic painful knee osteoarthritis (OA), as determined by the presence of synovitis or joint effusion at ultrasonography (US); and to evaluate the correlation between synovitis, effusion, and ..
- EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utilityP Conaghan
Rheumatology Department, Cochin Hospital, 27, rue du Faubourg St Jacques, 75014 Paris, France
Ann Rheum Dis 64:1710-4. 2005..Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression...
- Power Doppler ultrasound, but not low-field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activityViolaine Foltz
University of Paris VI and Rheumatology Department, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 64:67-76. 2012..The aim of this study was to compare the ability of ultrasonography and magnetic resonance imaging (MRI) to predict relapse and radiographic progression in these patients...
- Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trialPhilip G Conaghan
Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
Ann Rheum Dis 72:1287-94. 2013..This randomised, double-blind, placebo-controlled phase IIIb study evaluated the impact of abatacept on MRI pathology as a primary outcome in methotrexate (MTX)-refractory patients with rheumatoid arthritis...
- The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysisF Pessler
The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
Ann Rheum Dis 67:1184-7. 2008..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
- Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progressionEsperanza Naredo
Hospital Severo Ochoa, Madrid, Spain
Arthritis Rheum 57:116-24. 2007....
- Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritisAri Kobayashi
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
Arch Pathol Lab Med 131:563-70. 2007..Matrix metalloproteinase 3 (MMP-3) is expressed in synovial tissues and involved in cartilage destruction in rheumatoid arthritis and osteoarthritis...
- Active foot synovitis in patients with rheumatoid arthritis: applying clinical criteria for disease activity and remission may result in underestimation of foot joint involvementMihir D Wechalekar
Queen Elizabeth Hospital and Flinders University, Adelaide, South Australia, Australia
Arthritis Rheum 64:1316-22. 2012..To determine whether application of criteria for remission in rheumatoid arthritis (RA) may result in underestimation of foot joint involvement among patients in a clinic setting...
- Arthroscopic assessment for intra-articular disorders in residual ankle disability after sprainMasato Takao
Department of Orthopaedic Surgery, Shimane University School of Medicine, 89 1 Enya, Izumo, Shimane 693 8501, Japan
Am J Sports Med 33:686-92. 2005..After ankle sprain, there can be many causes of disability, the origins of which cannot be determined using standard diagnostic tools...
- Imaging of synovitis in osteoarthritis: current status and outlookDaichi Hayashi
Department of Radiology, Boston University School of Medicine, Boston, MA, USA
Semin Arthritis Rheum 41:116-30. 2011This review article provides an overview of the current state of imaging of synovitis in osteoarthritis (OA), looking at recent advances and controversies and focusing particularly on the application of ultrasound and magnetic resonance ..
- Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritisAtsushi Hashimoto
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, Japan
J Rheumatol 34:2144-53. 2007....
- Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generationEric Boilard
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 186:4361-6. 2011..In this study, we demonstrate that platelets, and not platelet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin in an autoimmune arthritis model...
- The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot studyKirsty E Haslam
Department of Paediatric Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Rheumatology (Oxford) 49:123-7. 2010Adult studies have demonstrated that ultrasonography (US) is more sensitive at detecting synovitis than clinical examination...
- Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin KJukka Morko
University of Turku, Turku, Finland
Arthritis Rheum 52:3713-7. 2005..The availability of transgenic UTU17 mice, which exhibit constitutive overexpression of the cathepsin K gene, prompted us to study possible arthritic changes in their knee joints...
- Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathologyB Volck
Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark
Osteoarthritis Cartilage 9:203-14. 2001....
- Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritisMaxime Dougados
Medicine Faculty, Rheumatology B Department, Descartes University UPRES EA 4058 APHP, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
Ann Rheum Dis 69:828-33. 2010To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter.
- MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progressionPernille Bøyesen
Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N 0319 Oslo, Norway
Ann Rheum Dis 70:428-33. 2011..To determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA)...
- Power Doppler ultrasonography for assessment of synovitis in the metacarpophalangeal joints of patients with rheumatoid arthritis: a comparison with dynamic magnetic resonance imagingM Szkudlarek
The Danish Research Center of Magnetic Resonance, University of Copenhagen Hvidovre Hospital, Denmark
Arthritis Rheum 44:2018-23. 2001..9%. CONCLUSION: PDUS was reliable for assessing inflammatory activity in the MCP joints of RA patients, using dynamic MRI as the standard. PDUS and clinical assessment of joint swelling/tenderness were only weakly correlated...
- The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritisH I Keen
Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, University of Leeds, Leeds, UK
Ann Rheum Dis 67:651-5. 2008..We aimed to develop a preliminary US hand OA scoring system, initially focusing on relevant pathological features with potentially high reliability...
- Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritisJuan D Canete
Institut Clínic de l Aparell Locomotor, and Unitat d Artritis, Servei de Reumatologia, Hospital Clinic de Barcelona, Villaroel 170, 08036 Barcelona, Spain
Arthritis Rheum 50:1636-41. 2004..Accordingly, angiogenesis may be an important therapeutic target in PsA. The aim of this study was to analyze the effects of infliximab on angiogenesis in the synovial membrane of patients with PsA who responded to this therapy...
- Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathyDominique Baeten
Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
Arthritis Res Ther 7:R359-69. 2005..activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes and/or ..
- Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRIF W Roemer
Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
Osteoarthritis Cartilage 18:1269-74. 2010To describe the anatomical distribution of synovitis and its association with joint effusion on non-enhanced and contrast-enhanced (CE) MRI in patients with knee osteoarthritis (OA).
- Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitisSadaf Ashraf
Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, Nottingham, UK
Arthritis Rheum 62:1890-8. 2010To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and whether inhibiting this angiogenesis at the onset of persistent inflammation leads to its subsequent resolution.
- Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitisPaul W Cook
Department of Dermatology, The Oregon Health Sciences University, Portland, OR, USA
Exp Dermatol 13:347-56. 2004..mice displayed normal knee joint histology, while 2- to 3-week-old K14-ARGE transgenic mice frequently displayed synovitis, as exemplified by the presence of a mixed leukocytic infiltration, increased vascularization, and enhanced ..
- Quantitative determination of the diagnostic accuracy of the synovitis score and its componentsElisabeth Slansky
Medical Faculty Carl Gustav Carus, Technical University of Dresden, Germany
Histopathology 57:436-43. 2010To assess the diagnostic accuracy of a three-component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power.
- Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysisA Ogdie
Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Biomarkers 15:183-90. 2010..44). Multicategory ROC analysis ranked Ki-67, subintimal CD68, and CD15 as discriminating best among all six sample groups, and thus identified them as the most broadly applicable markers...
- Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)Thierry Marhadour
Rheumatology Unit, CHU, and University Hospital La Cavale Blanche, Brest, France
J Rheumatol 37:932-7. 2010To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28).
- Microarray analysis of IL-1beta-stimulated chemokine genes in synovial fibroblasts from human TMJNaomi Ogura
Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan
J Oral Pathol Med 36:223-8. 2007..Gene expression profile of synovial fibroblasts stimulated with IL-1beta was studied by oligonucleotide microarray analysis to elucidate candidate genes associated with intracapsular pathologic conditions of TMJ...
- The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumabHilde Berner Hammer
Dept of Rheumatology, Diakonhjemmet Hospital, Box 23, 0319 Oslo, Norway
Arthritis Res Ther 13:R178. 2011..Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power Doppler (PD))...
- Low-intensity pulsed ultrasound reduces the inflammatory activity of synovitisTatsuya Nakamura
Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Ann Biomed Eng 39:2964-71. 2011..membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis...
- Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity stateFrédérique Gandjbakhch
Department of Rheumatology, Pitie Salpetriere Hospital, APHP, Universite Paris 6 UPMC, Paris, France
J Rheumatol 38:2039-44. 2011..Our objective was to determine the MRI characteristics of RA patients in clinical remission or low disease activity (LDA) state...
- An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritisA K Brown
Leeds Institute of Molecular Medicine, University of Leeds, and Chapel Allerton Hospital, Leeds, UK
Arthritis Rheum 58:2958-67. 2008..The purpose of this study was to evaluate the long-term significance of subclinical synovitis and its relationship to structural outcome.
- The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasoundMaxime Dougados
Hopital Cochin, Rheumatology, Clinique de Rhumatologie B, Groupe Hospitalier Cochin, Paris 75014, France
Ann Rheum Dis 72:665-71. 2013To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA).
- Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trialPhilip G Conaghan
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
Ann Rheum Dis 70:1968-74. 2011..To evaluate golimumab's effect on MRI-detected inflammation and structural damage in patients with active rheumatoid arthritis (RA) despite methotrexate (MTX)...
- Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flowJie Li
University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 65:130-8. 2013..The aim of this study was to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells...
- Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger jointsM Backhaus
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Germany
Ann Rheum Dis 61:895-904. 2002..Additionally, to study the course of soft tissue lesions depicted in the initial study in comparison with the clinical findings...
- The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitisWeijia Dong
Department of Clinical Immunology, State Key Discipline of Cell Biology, Xijing Hospital, Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, Shaanxi, PR China
Arthritis Res Ther 11:R4. 2009..the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic autoantibodies.
- Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitisGabriele Simonini
Azienda Ospedaliero Universitaria Meyer, Florence, Italy
Arthritis Rheum 65:513-8. 2013....
- MRI comes of age in RA clinical trialsCharles Peterfy
Spire Sciences, LLC, San Francisco, California, USA
Ann Rheum Dis 72:794-6. 2013..than radiographs, but importantly it can measure the upstream drivers of erosions and cartilage loss, synovitis and osteitis...
- Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA databaseChikashi Terao
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
PLoS ONE 8:e59341. 2013..We also found that RA synovitis could be classified into three categories of joints in the correlation analyses: large joints with wrist joints, ..
- Reliability of ultrasonography to detect synovitis in rheumatoid arthritis: a systematic literature review of 35 studies (1,415 patients)Peter P Cheung
Paris Descartes University, Cochin Hospital, Paris, France
Arthritis Care Res (Hoboken) 62:323-34. 2010To perform a systematic review on the reliability of ultrasonographic (US) synovitis detection in rheumatoid arthritis (RA) by B-mode and power Doppler (PD) in image acquisition and still-image interpretation...
- Bone oedema predicts erosive progression on wrist MRI in early RA--a 2-yr observational MRI and NC scintigraphy studyKari Palosaari
Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 50, FIN 90029, Box 50, Oulu, Finland
Rheumatology (Oxford) 45:1542-8. 2006..To investigate if disease assessment by contrast-enhanced dynamic and static magnetic resonance imaging (MRI) and quantitative nanocolloid (NC) scintigraphy gives useful additional information in early rheumatoid arthritis (RA)...
- Magnetic resonance imaging in rheumatoid arthritis clinical trials: emerging patterns based on recent experienceCharles G Peterfy
Spire Sciences, LLC, San Francisco, CA, USA
J Rheumatol 38:2023-30. 2011..In this study, we pool MRI data from randomized controlled clinical trails (RCT) to determine which combination of MCP and wrist joints are most sensitive and discriminative for structural changes over time...
- The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritisDirk Wernicke
Medical Center for Rheumatology Berlin Buch, Karowerstr 11, Berlin 13 125, Germany
Autoimmunity 39:307-13. 2006..analysis of the synovial tissue is important to distinguish rheumatoid arthritis (RA) from other forms of synovitis and to provide information about prognosis and therapeutic strategies at early stages of the disease...
- Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST studyFrank W Roemer
Department of Radiology, Boston University Medical Center, FGH Building, 3rd Floor, 820 Harrison Avenue, Boston, MA 02118, USA
Ann Rheum Dis 70:1804-9. 2011To evaluate if two different measures of synovial activation, baseline Hoffa synovitis and effusion synovitis, assessed by MRI, predict cartilage loss in the tibiofemoral joint at 30 months follow-up in subjects with neither cartilage ..
- Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritisR Torres
Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA
Ann Rheum Dis 68:1602-8. 2009..However, consequences of IL1 inhibition have not been explored in more clinically relevant models of crystal-induced arthritis...
- A comparison of clinical vs ultrasound determined synovitis in rheumatoid arthritis utilizing gray-scale, power Doppler and the intravenous microbubble contrast agent 'Sono-Vue'J D Rees
Department of Rheumatology, St George s Healthcare NHS Trust, London, UK
Rheumatology (Oxford) 46:454-9. 2007b>Synovitis in rheumatoid arthritis (RA) is assessed clinically by the presence of joint tenderness and swelling...
- Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the ratE Ekundi-Valentim
Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
Br J Pharmacol 159:1463-74. 2010..This study was undertaken to evaluate the ability of endogenous and exogenous H(2)S to modulate carrageenan-induced synovitis in the rat knee.
- No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography studyUffe Møller Døhn
Department of Rheumatology, Copenhagen University Hospitals at Hvidovre and Glostrup, Hvidovre, Denmark
Ann Rheum Dis 70:252-8. 2011..To assess the predictive value of MRI and ultrasonography for erosive progression on CT and compare MRI/ultrasonography/radiography for erosion detection/monitoring...
- Temporomandibular joint pain: relationship to internal derangement type, osteoarthrosis, and synovial fluid mediator level of tumor necrosis factor-alphaR Emshoff
University of Innsbruck, Department of Oral and Maxillofacial Surgery, Austria
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:442-9. 2000..was to investigate whether patients with temporomandibular joint (TMJ)-related pain classified as capsulitis/synovitis may be linked to magnetic resonance imaging (MRI) findings of internal derangement, osteoarthrosis, or the ..
- Imaging of osteoarthritis: update from a radiological perspectiveAli Guermazi
Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Curr Opin Rheumatol 23:484-91. 2011..To assist investigators in choosing the appropriate imaging technique for a particular goal of a study, this review describes, from a radiological point of view, key studies that were published between May 2010 and May 2011...
- Magnetic resonance imaging findings of internal derangement, osteoarthrosis, effusion, and bone marrow edema before and after performance of arthrocentesis and hydraulic distension of the temporomandibular jointRüdiger Emshoff
Department of Oral and Maxillo Facial Surgery, University Clinic of Innsbruck, Innsbruck, Austria
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:784-90. 2006To investigate whether temporomandibular joint (TMJ) internal derangement type III and capsulitis/synovitis are related to magnetic resonance imaging (MRI) diagnoses of internal derangement, osteoarthrosis (OA), effusion, and/or bone ..
- Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patientsMikkel Østergaard
Department of Rheumatology, Copenhagen University Hospital at Glostrup, Glostrup, Denmark
Arthritis Rheum 63:3712-22. 2011..To evaluate the effects of golimumab on inflammation/structural damage detected by magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA)...
- Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathiesF Pessler
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Ann Rheum Dis 67:162-7. 2008..We evaluated subintimal Ki-67+ cell density as a tissue biomarker for inflammatory arthropathies and compared it to subintimal CD68, a synovial biomarker of RA...
- An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlasM Østergaard
Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
Ann Rheum Dis 64:i3-7. 2005..With this atlas, MRIs of wrist and metacarpophalangeal joints of patients with rheumatoid arthritis can be scored for synovitis, bone oedema, and bone erosion, guided by standard reference images.
- A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritisJ Song
Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea
Eur J Nucl Med 28:489-97. 2001..study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA)...
- High prevalence of ultrasonographic synovitis and enthesopathy in patients with psoriasis without psoriatic arthritis: a prospective case-control studyEsperanza Naredo
Department of Rheumatology, Hospital Universitario Severo Ochoa, 28033 Madrid, Spain
Rheumatology (Oxford) 50:1838-48. 2011To investigate the presence of synovitis, tenosynovitis and enthesitis with power Doppler (PD) ultrasonography (US) in patients with psoriasis without musculoskeletal diseases as compared with controls with other skin diseases without ..
- Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidusY Kawaguchi
Department of Orthopaedic Surgery, Kagawa Medical University, Kita gun, Japan
Mod Pathol 13:1086-91. 2000To clarify the condition of development of synovitis associated with intraarticular osteoid osteoma (OO), expressions of cyclooxygenase-2 (COX-2) protein and its messenger ribonucleic acid were investigated both in the nidus and the ..
- Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritisSylvain Breton
Unit of Radiology, CHU Brest, Universite de Bretagne Occidentale, Faculte de Medecine et des Sciences de la Sante, Brest, France
Semin Arthritis Rheum 41:272-8. 2011The characteristics of synovitis in juvenile idiopathic arthritis (JIA) are important to evaluate, as they define several clinical categories. The metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints are frequently involved...
- Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitisAndrew Filer
Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham B15 2TT, UK
Ann Rheum Dis 70:500-7. 2011..This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis.
- The role of IFN regulatory factor-1 in synovitis and nitric oxide productionA Shiraishi
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
J Immunol 159:3549-54. 1997..These results indicate that IRF-1 has a tissue-specific role in the induction of iNOS. Inhibition of this transcription factor may represent a novel approach in controlling inflammatory diseases such as arthritis...
- Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinHyun Mi Choi
East West Bone and Joint Research Institute, East West Neo Medical Center, Kyung Hee University, 149 Sangil dong, Gangdong gu, Seoul, 134 727, Republic of Korea
Arthritis Res Ther 11:R161. 2009....
- CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritisSanna Rosengren
Division of Rheumatology, Department of Medicine, Allergy and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0656, La Jolla, CA 92093 0656, USA
Rheumatology (Oxford) 50:603-10. 2011The B-cell chemokine, CXCL13, is a proposed serum biomarker of synovitis in RA. Its behaviour in the context of B-cell depletion therapy and reconstitution was studied during treatment of RA with rituximab.
- Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patientsPernille Bøyesen
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Ann Rheum Dis 70:176-9. 2011..To examine the associations between modern imaging modalities and joint damage measured as 1-year MRI erosive progression, in early rheumatoid arthritis (RA) patients...
- Remitting seronegative symmetrical synovitis with pitting oedema: a study of 12 casesS Paira
Hospital José M Cullen, Santa Fe, Argentina
Clin Rheumatol 21:146-9. 2002Twelve patients with remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) were analysed. Eight of them had typical RS3PE without underlying disease, and four presented associated neoplasia...
- Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic miceYasuo Niki
Department of Orthopedic Surgery, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Immunol 172:577-84. 2004..These results suggest that MA-IL-1 contributes to synoviocyte self-proliferation and subsequent cartilage destruction in inflammatory joint disease such as rheumatoid arthritis...
- Targeted ultrasound of the fifth metatarsophalangeal joint in an early inflammatory arthritis cohortBarry J Sheane
St James s Hospital, Dublin, Ireland
Arthritis Rheum 61:1004-8. 2009..The earlier detection of erosion may facilitate the timely initiation of disease-modifying antirheumatic drug therapy, particularly in patients with undifferentiated synovitis.
- Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathiesElli Kruithof
Ghent University Hospital, Ghent, Belgium
Arthritis Rheum 52:3898-909. 2005..may have distinct immunomodulatory effects on specific disease manifestations, the present study was carried out to investigate the immunomodulating effects of etanercept on peripheral synovitis in the spondylarthropathies (SpA).
- The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritisC L Peters
University of Bath, Bath, UK
Arthritis Rheum 50:291-6. 2004..Adjuvant-induced arthritis (AIA) was used as the model system, since it mirrors many aspects of the pathology of rheumatoid arthritis...
- The role of cytokines in osteoarthritis pathophysiologyJulio C Fernandes
Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Biorheology 39:237-46. 2002..Future directions in the research and treatment of osteoarthritis (OA) will be based on the emerging picture of pathophysiological events that modulate the initiation and progression of OA...
- Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolonePatrick Durez
Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium
Arthritis Rheum 56:3919-27. 2007..MTX), alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab, on magnetic resonance imaging (MRI)-detected synovitis, bone edema, and erosive changes in patients with early rheumatoid arthritis (RA).
- Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritisSilvia Magni-Manzoni
Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Arthritis Rheum 61:1497-504. 2009To compare clinical evaluation and ultrasonography (US) in the assessment of joint synovitis in children with juvenile idiopathic arthritis (JIA).
- Suppression of Collagen Induced Arthritis with Altered Peptide LigandsAndrew H Kang; Fiscal Year: 2010..This systemic disease is characterized by chronic synovitis, sustained by an antigen-driven immune process against one or more proteins found in cartilage...
- Pro-inflammatory role of megakaryocytes in arthritisPeter A Nigrovic; Fiscal Year: 2013..Together, these studies have the potential to identify a previously unrecognized cellular contributor to synovitis and to begin to unravel the mechanisms underlying the ability of megakaryocytes to participate in a systemic ..
- The Role of MicroRNA in Rheumatoid Arthritis PathogenesisHiroshi Asahara; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE. Rheumatoid arthritis (RA) is characterized by chronic synovitis and subsequent cartilage and bone destruction;however, its etiology and precise pathogenetic mechanisms remain ..
- Cadherin-11 growth factor receptor interactions in RA fibroblast hyperplasiaERIKA HEIDI NOSS; Fiscal Year: 2013..Aim 3 demonstrates the relevance of cad11 PDGFR interactions to synovitis development by using a mouse inflammatory arthritis model to examine the effect of loss of cad11 expression on ..
- CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPELionel B Ivashkiv; Fiscal Year: 2013..Therefore, we have set out to determine which factors present during synovitis are capable of suppressing osteoclastogenesis, and to determine their mechanisms of action...
- Role of CCR7 in Clinical Response in Inflammatory ArthritisRichard M Pope; Fiscal Year: 2013..Additionally, CCR7 deficient mice demonstrate more chronic immune complex mediated arthritis, and the synovitis is highly enriched in macrophages...
- Central Sensitization in Post-Knee Replacement Pain and Relation to OA PathologyTuhina Neogi; Fiscal Year: 2013..relation of: 1) central sensitization to pain post-KR;2) the duration and severity inflammatory features of OA (synovitis, effusion) as well as inflammatory mediators that may act locally or systemically (TNF-[unreadable], adiponectin,..
- B cells and draining lymph node function in arthritic flairEdward M Schwarz; Fiscal Year: 2013..An unexpected finding was that LN collapse appears to preceded the onset of knee synovitis and focal erosions, and that preliminary studies showed that both anti-CD20 and anti-CXCL13 treatment of TNF-Tg ..
- UNIQUE SURFACE STRUCTURES ON SYNOVIAL CELLSDAVID ALAN FOX; Fiscal Year: 2011..and even fatal immune-mediated disease, in which the major manifestation is typically chronic, polyarticular synovitis that leads to destruction of cartilage and bone, with ensuing joint deformity and dysfunction...
- "Mechanisms of IL-35 Protection Against Arthritis"David W Pascual; Fiscal Year: 2011..by applicant): Rheumatoid arthritis (RA), a chronic inflammatory disease of the joints, manifests as a chronic synovitis and progressive destruction of the joints, leukocyte infiltrates, and cartilage destruction and bone erosion...
- Physiology of Inflammatory Arthritis in High ResolutionXueding Wang; Fiscal Year: 2013..More interestingly, we will explore the potential of SPAT in assessing new physiological biomarkers of synovitis including hyperemia and hypoxia...
- USE OF THERMAL AND 3D IMAGING TO QUANTIFY ARTHRITISRaphael Hirsch; Fiscal Year: 2010..It has recently been reported that patients in clinical remission often have MRI evidence of continued synovitis, demonstrating that current clinical measures of inactivity do not correlate well with true remission...
- CD8 T Cells in Rheumatoid ArthritisCornelia M Weyand; Fiscal Year: 2013..through which pathways adoptively transferred CD8+CCR7+ Tregs suppress the inflammatory activity of rheumatoid synovitis. Finally, we will explore how CD8+CCR7+ Tregs communicate with adjacent CD4 T cells and seek to identify ..
- Autoimmunity to ECGF in Lyme disease and its post-infectious syndromesAllen C Steere; Fiscal Year: 2012..We have studied this problem previously in patients with Lyme arthritis who have persistent synovitis for months or years after spirochetal killing with antibiotics, called antibiotic-refractory Lyme arthritis...
- Effect of Intra-Articular Steroids on Structural Progression of Knee OA: An RCTTimothy E McAlindon; Fiscal Year: 2013..that they might influence OA progression is new, and derives from the recent observation of a high prevalence of synovitis in OA knees...
- Autoimmunity to ECGF in Lyme disease and its post-infectious syndromesAllen C Steere; Fiscal Year: 2013..In recent years, we have studied this problem intensively in patients with Lyme arthritis in whom synovitis persists for months or years after spirochetal killing with antibiotics, called antibiotic-refractory arthritis...
- Large-Scale Characterization of Autoantibody Responses in Rheumatoid ArthritisWilliam H Robinson; Fiscal Year: 2013DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is an autoimmune synovitis that affects 0.5% of the world population, yet the key autoantigen targets remain unknown...
- TAS::75 0888::TAS BIOMEDICAL (APPLIED/EXPLORATORY)Kent Kwoh; Fiscal Year: 2010..e., large bone marrow lesions, full thickness cartilage defect, synovial effusion/synovitis, and/or meniscal abnormalities) and altered subchondral bone morphology (i.e...
- Cellular and Molecular Effectors of SynovitisPaul J Anderson; Fiscal Year: 2010..in macrophage/dendritic cells trigger an immune cascade that induces the expression of IFN-gamma and suppresses synovitis. Project 2 will determine how neutrophil-derived LTB4 targets synovial fibroblasts to promote synovitis...
- 99mTc-DTB-Antifol-Pteroyls (RadioDAPs): Theranostics for Rheumatoid ArthritisJohn A Zebala; Fiscal Year: 2011..There is now evidence that active subclinical synovitis and progressive joint destruction occurs in patients despite ongoing drug therapy and apparent clinical ..
- Early Aggressive Therapy in Juvenile Idiopathic ArthritisCarol Wallace; Fiscal Year: 2009..with JIA have polyarthritis (poly-JIA), which is associated with persistently active disease characterized by synovitis, joint damage, decreased physical functional ability, and a progressive decrease in quality of life...
- CD8 T Cells in Rheumatoid ArthritisCornelia M Weyand; Fiscal Year: 2010..is designed to explore the mechanisms through which CD8+CD28~CD56+ T suppressor cells inhibit rheumatoid synovitis and how they can be developed into a novel adoptive immunotherapy for this crippling disease Exploiting the ..
- The PRESS ERA: Protein &Resistance Exercise Supplement Study for Elderly with RARebecca Manno; Fiscal Year: 2013..DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovitis and arthritis. The arthritis in RA can be erosive and destructive leading to pain, disability, and deformity...
- C5a receptor on mast cells in inflammatory arthritisPeter A Nigrovic; Fiscal Year: 2010..provided by applicant): Inflammatory arthritis is a major national health care priority, yet the mechanisms of synovitis remain incompletely understood...
- Quantitative 3D Diffusion and Relaxometry MRI of the KneeBRIAN ANDREW HARGREAVES; Fiscal Year: 2013..and thickness measurements, T2 and T2* maps and ADC maps, and (3) a non-contrast-enhanced method to assess synovitis. The significance of this proposal is to offer a widely available, quantitatively validated 10-minute imaging ..
- Restitution of Lubrication in ACL Deficient Joints Preventing WearGregory Jay; Fiscal Year: 2009..These patients present to emergency departments and manifest an acute traumatic synovitis (TS) secondary to structural defects such as acute anterior cruciate ligament (ACL) injuries following trauma...
- Development of UTL-5b for Rheumatoid Arthritis: Mechanism of ActionJiajiu Shaw; Fiscal Year: 2007..to assess disease progression to joint distortion and spondylitis, and histopathology of affected joints reveals synovitis, pannus formation, and cartilage and bone erosion, which is represented by a validated index...
- DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITISClement Sledge; Fiscal Year: 1992..other joints), our preliminary studies in hemophilic arthropathy of the knee and pigmented villonodular synovitis indicate a high degree of probability that radiation synovectomy will be useful in these disorders as well...
- BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMAMERRILL GERSHWIN; Fiscal Year: 2004..controlled trials (RCT) demonstrating efficacy of dietary GLA in patients with rheumatoid arthritis and active synovitis. Ginkbo biloba, a flavonoid-rich extract of leaves of the Ginkbo biloba tree, has been studied in one RCT with ..
- OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASESANDREAS HIELSCHER; Fiscal Year: 2007..studies we now believe that three main processes (effusion, erosion, and hypertrophy of the synovial membrane (synovitis)) that accompany RA can be distinguished by optical tomography (OT)...
- INCIDENCE & IDENTITY OF THE RA-1 PARVOVIRUSRobert Simpson; Fiscal Year: 1990..Synovial fluid and paired blood samples from patients with early synovitis or diagnosed RA will be included in this survey...
- Treatment of Early Aggressive Rheumatoid Arthritis TEARLarry Moreland; Fiscal Year: 2001..defined by presence of erosions on hand or feet radiographs, or positive serum rheumatoid factor, plus active synovitis of multiple joints...
- LOW DENSITY LIPOPROTEIN AND INFLAMMATIONRobert Terkeltaub; Fiscal Year: 1993..the extent of modification of oxidized LDL required for it to be proinflammatory in a rat model of acute synovitis (injection into subcutaneous air pouches)...
- CLONAL DOMINANCE OF T-LYMPHOCYTES IN ARTHRITISJAMES KURNICK; Fiscal Year: 1991..These studies will draw upon our original observation that synovitis in patients with rheumatoid arthritis (RA) is characterized by the presence of "dominant" T cell clones which ..
- RHEUMATOID ARTHRITIS, 1993Edward Harris; Fiscal Year: 1993..Factor" (Lipsky), "Overview on Rheumatoid Factor" (Natvig), "The Proliferative Lesion of Rheumatoid Arthritis Synovitis and its Destructive Potential" (Krane), "Determining Prognosis and Disease Activity in Rheumatoid Arthritis" (..
- The Relationship of n-3 Fatty Acids with Pain and Synovium in knee OAKristin Baker; Fiscal Year: 2009..In the research plan we propose to investigate a potential nutrition therapy for synovitis and pain in knee osteoarthritis...
- N-glycolylneuraminic Acid in the Pathogenesis and Progression of Rheumatoid ArthrNancy Hurtado Ziola; Fiscal Year: 2009..immune complexes in some RA patients, and that such complexes can contribute to the development of inflammatory synovitis. This application shows the presence of Neu5Gc in synovial tissue and fluid and preliminary data on anti-Neu5Gc ..
- Adeno-Associated Virus-Mediated Synovial Gene TransferRaphael Hirsch; Fiscal Year: 2006..The effects on synovitis and cartilage destruction of local, versus systemic, expression will be compared...
- REGULATION OF CELL ACTIVATION BY FATTY ACIDSROBERT ZURIER; Fiscal Year: 2000..Administration of GLA suppresses joint pain and swelling in RA patients with active synovitis. The means whereby GLA, DGLA and other unsaturated fatty acids influence transduction of activation signals from ..
- Pathogenic mechanisms in chlamydial reactive arthritisJUDITH WHITTUM HUDSON; Fiscal Year: 2005..Synovial tissue from knees of these animals exhibits histologic signs of synovitis including increased synovial lining cells, dilated vessels, and foci of mononuclear inflammatory cells, and is ..
- TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINEAlun Jones; Fiscal Year: 1999..suitable for radiation synovectomy, particularly for treatment of rheumatoid arthritis and pigmented villonodular synovitis. The use of soluble agents may allow a wider use of this therapy in joints smaller than the knee and ankle.
- Treg and Antigen Presentation in AutoimmunityFei Shih; Fiscal Year: 2007..mechanisms whereby systemic T cell autoreactivity can result in diverse disease phenotype from joint centered synovitis to a fulminant multi-organ inflammation...
- STATS AND THE PATHOGENESIS OF RHEUMATOID ARTHRITISLionel Ivashkiv; Fiscal Year: 2000..However, the complexity of cytokine expression has limited analysis of mechanisms by which cytokines regulate synovitis and has limited the identification of the most important cytokines...
- SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITISKenneth Brandt; Fiscal Year: 1992..The second is a clinical research project, which deals with the importance of synovitis as a cause of pain in OA tasks whether treatment with a nonsteroidal anti-inflammatory drug is more effective in ..
- COLLAGEN INDUCED ARTHRITIS--SPECIFICITY OF T CELLSErnest Brahn; Fiscal Year: 1992..Certain lines induce a synovitis when injected intraarticularly (I.A...
- RHEUMATOID ARTHRITIS--ADHERENCE INTERVENTION STRATEGIESJacqueline Dunbar Jacob; Fiscal Year: 2002..this population, as pharmacological treatment is directed toward the suppression of inflammation and resulting synovitis and the prevention of disability...
- LYMPHOKINES IN RHEUMATOID ARTHRITISGary Firestein; Fiscal Year: 1991The perpetuation of rheumatoid synovitis will be studied in the context of an autologous mixed lymphocyte reaction (AMLR) model...
- MECHANISMS OF TISSUE INJURY IN RHEUMATOID ARTHRITISLarry Moreland; Fiscal Year: 2000..central focus of this application is to examine two hypotheses concerning the pathophysiology of inflammatory synovitis in rheumatoid arthritis -- that continual local activation of T cells to produce Th1-like cytokines is the key ..
- MOLECULAR GENETIC BASIS OF RF IN RADick Robbins; Fiscal Year: 1993..b>Synovitis is central to the immunopathologic events in RA, thus it is likely that RF made there are of greater ..
- Planing an Early RA Prevention TrialDavid Pisetsky; Fiscal Year: 2005..by Immediate Definitive Therapy) and is designed to determine the impact of DMARD therapy in patients with early synovitis. The study will have 5 arms consisting of patients administered DMARD therapy (methotrexate alone or ..
- ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITISAndrea Cerutti; Fiscal Year: 2003..by accumulating in the joints as highly reactive immunocomplexes, play a central role in the pathogenesis of synovitis. The mechanisms underlying the dysregulation of Ig class switching and antibody production in RA patients remain ..
- REGULATION OF COLLAGENASE GENE EXPRESSIONConstance Brinckerhoff; Fiscal Year: 2006..suggest that RA patients with this allele may display heightened MMP-1 expression and particularly erosive synovitis. Thus, the specific aims are to (1) recapitulate the pathogenesis of RA in a rabbit model of polycation-induced ..
- REGULATION OF INFLAMMATION IN EXPERIMENTAL ARTHRITISJOHN SCHWAB; Fiscal Year: 1993..test the capacity of several highly purified cytokine or eicosanoid mediators to cause reactivation of erosive synovitis which has been initiated by PG-APS...
- Strategies for Evaluating and Treating Early SynovitisDavid Pisetsky; Fiscal Year: 2004..Risk Rheumatic and Musculoskeletal and Skin Diseases Research grant is to develop a strategy for studying early synovitis and provide a framework to test the window-of-opportunity hypothesis in the treatment of rheumatoid arthritis (..
- THROMBOSPONDIN AND T CELLSABBE DE VALLEJO; Fiscal Year: 2000..An analysis of CD47-dependent effector functions of CD4+CD28null T cells could provide valuable insights on the role of these unusual cells in the pathogenesis of rheumatoid synovitis.
- IDO: A Novel Endogenous Suppressor of InflammationJohn Varga; Fiscal Year: 2002..The pathogenesis of rheumatoid synovitis involves complex interaction between T lymphocytes, autonomously activated fibroblast-like synovial cells (FLS) ..
- MICROVASCULAR MECHANISMS OF ARTICULAR DAMAGE IN ANTIGENMaren Mahowald; Fiscal Year: 1991..with oral coumadin to examine the effects of blocking the initial microvascular occlusion in immune mediated synovitis. 2) AIA rabbits treated with oral heparin to enhance angiogenesis; and 3) AIA rabbits treated with oral heparin ..
- Oral Interferon Treatment in collagen induced arthritisPatricia Nelson; Fiscal Year: 2003..We hypothesize that IFN/tau will induce a systemic Th2 response in mice sensitized to collagen and reduce synovitis when administered after the onset of overt disease...
- T CELL SPECIFICITY AND FUNCTION IN LYME SYNOVITISMichael Vincent; Fiscal Year: 2000..development plan is proposed encompassing laboratory investigations on the role of gamma/delta T cells in Lyme synovitis and a curriculum in immunology, autoimmunity, and the conduct of responsible, clinically relevant research...
- DNA VACCINE MEDIATED IMMUNOTHERAPY OF RHEUMATIC DISEASEWilliam Robinson; Fiscal Year: 2004..RA is a chronic autoimmune inflammatory synovitis affecting 1 percent of the world population...
- CLONALITY AND TCR GENES OF RA AND LYME SYNOVIAL T CELLSSHELDON COOPER; Fiscal Year: 1993..such T cells are identified, it is likely that they will be specific for antigens that induce or perpetuate the synovitis. T cells will be cloned immediately from synovial tissue, eliminating the potential for expansion of selected ..
- SPECIALIZED CENTER OF RESEARCH IN RHEUMATOID ARTHRITISDavid Pisetsky; Fiscal Year: 2000..Project 1 will focus on the role of CD44 in mediating adhesive interactions in synovitis and the contribution of CD7 negative T cells in promoting synovial inflammation...