synovitis

Summary

Summary: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)

Top Publications

  1. ncbi Musculoskeletal ultrasound including definitions for ultrasonographic pathology
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2485-7. 2005
  2. ncbi The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
    Jeremie Sellam
    Pierre and Marie Curie University, Department of Rheumatology, AP HP Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, Paris 75012, France
    Nat Rev Rheumatol 6:625-35. 2010
  3. ncbi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
  4. pmc The role of synovitis in osteoarthritis pathogenesis
    Carla R Scanzello
    Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Bone 51:249-57. 2012
  5. pmc Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients
    M Chemel
    INSERM, UMR 957, France
    Ann Rheum Dis 71:150-4. 2012
  6. ncbi Synovitis score: discrimination between chronic low-grade and high-grade synovitis
    V Krenn
    Institute for Pathology, Trier, and Department for Rheumatology, Charite University Hospital, Berlin, Germany
    Histopathology 49:358-64. 2006
  7. ncbi Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort
    Mohammed Z Cader
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Ann Rheum Dis 70:949-55. 2011
  8. ncbi Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study
    D Baeten
    Department of Rheumatology, Ghent University, Belgium
    Arthritis Rheum 44:186-95. 2001
  9. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
  10. ncbi OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system
    Mikkel Østergaard
    Danish Research Center of Magnetic Resonance and Department of Rheumatology at the Copenhagen University Hospital at Hvidovre, Denmark
    J Rheumatol 30:1385-6. 2003

Detail Information

Publications278 found, 100 shown here

  1. ncbi Musculoskeletal ultrasound including definitions for ultrasonographic pathology
    Richard J Wakefield
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    J Rheumatol 32:2485-7. 2005
    Ultrasound (US) has great potential as an outcome in rheumatoid arthritis trials for detecting bone erosions, synovitis, tendon disease, and enthesopathy...
  2. ncbi The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
    Jeremie Sellam
    Pierre and Marie Curie University, Department of Rheumatology, AP HP Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, Paris 75012, France
    Nat Rev Rheumatol 6:625-35. 2010
    ..breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain...
  3. ncbi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
    ..This work was undertaken to develop new classification criteria for RA...
  4. pmc The role of synovitis in osteoarthritis pathogenesis
    Carla R Scanzello
    Section of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA
    Bone 51:249-57. 2012
    ..The histological changes observed in the SM in OA generally include features indicative of an inflammatory "synovitis"; specifically they encompass a range of abnormalities, such as synovial lining hyperplasia, infiltration of ..
  5. pmc Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients
    M Chemel
    INSERM, UMR 957, France
    Ann Rheum Dis 71:150-4. 2012
    ..Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA)...
  6. ncbi Synovitis score: discrimination between chronic low-grade and high-grade synovitis
    V Krenn
    Institute for Pathology, Trier, and Department for Rheumatology, Charite University Hospital, Berlin, Germany
    Histopathology 49:358-64. 2006
    ..To standardize the histopathological assessment of synovial membrane specimens in order to contribute to the diagnostics of rheumatic and non-rheumatic joint diseases...
  7. ncbi Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort
    Mohammed Z Cader
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Ann Rheum Dis 70:949-55. 2011
    ..This study therefore assesses the performance of these new criteria in patients with early synovitis.
  8. ncbi Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study
    D Baeten
    Department of Rheumatology, Ghent University, Belgium
    Arthritis Rheum 44:186-95. 2001
    ..on synovial histology in patients with spondylarthropathy (SpA) in order to confirm the effect on peripheral synovitis and to investigate the immunologic mechanisms involved in anti-TNFalpha therapy...
  9. pmc Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    Yuqing Zhang
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:691-9. 2011
    ..This study was undertaken to determine whether pain resolution is accompanied by diminution of lesions in patients with knee OA...
  10. ncbi OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system
    Mikkel Østergaard
    Danish Research Center of Magnetic Resonance and Department of Rheumatology at the Copenhagen University Hospital at Hvidovre, Denmark
    J Rheumatol 30:1385-6. 2003
    ..MRI definitions of important RA joint pathologies, and a "core set" of basic MRI sequences for use in RA are also suggested...
  11. ncbi Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis
    Antonio Manzo
    Rheumatology Unit, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, UK
    Eur J Immunol 35:1347-59. 2005
    ..we analyzed the relationship between CXCL13 and CCL21 production and lymphoid tissue organization in rheumatoid synovitis as a model of a naturally occurring ectopic lymphoneogenesis...
  12. ncbi Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis
    Fiona M McQueen
    Auckland District Health Board and Auckland University, Auckland, New Zealand
    Arthritis Rheum 48:1814-27. 2003
    Magnetic resonance imaging (MRI) is capable of revealing synovitis and tendinitis in early rheumatoid arthritis (RA), as well as bone edema and erosion. These features are visible before radiographic joint damage occurs...
  13. ncbi Power Doppler ultrasound assessment of rheumatoid hand synovitis
    M Stone
    Department of Rheumatology, Mater Misericordiae Hospital, Dublin, Ireland
    J Rheumatol 28:1979-82. 2001
    ..power Doppler ultrasound (PD) as a technique in assessing response to treatment with steroids in rheumatoid hand synovitis. METHODS: Twelve patients with rheumatoid hand synovitis were assessed before and after treatment with steroids...
  14. ncbi Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis
    M Walther
    University of Wuerzburg, Germany
    Arthritis Rheum 44:331-8. 2001
    ..01). CONCLUSION: In the present study, PDS proved to be a reliable diagnostic method for qualitative grading of the vascularity of the synovial tissue. In clinical practice, PDS allows further differentiation of the hypertrophic synovium...
  15. ncbi Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis
    William P Arend
    Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA william arend ucdenver edu
    Nat Rev Rheumatol 8:573-86. 2012
    ..Subsequent engagement of Fc receptors and complement activation would lead to secondary inflammation in the synovium with induction of a perpetuating cycle of chronic synovitis.
  16. ncbi Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis
    Philip G Conaghan
    University of Leeds and Leeds General Infirmary, Leeds, UK
    Arthritis Rheum 48:64-71. 2003
    ..To simultaneously image bone and synovium in the individual joints characteristically involved in early rheumatoid arthritis (RA)...
  17. ncbi In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis
    Garifallia Sakellariou
    IRCCS Fondazione Policlinico San Matteo, Piazzale Golgi, Pavia 27100, Italy
    Ann Rheum Dis 72:245-9. 2013
    ..Rheumatology/European League Against Rheumatism (ACR/EULAR) and disease activity score in 44 and 28 joints (DAS, DAS28) definitions of remission in early rheumatoid arthritis (RA), against disability and ultrasound-detectable synovitis.
  18. ncbi A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis
    Alexander K Scheel
    Georg August University Gottingen, Germany
    Arthritis Rheum 52:733-43. 2005
    To develop an ultrasonographic (US) synovitis scoring system suitable for evaluation of finger joint inflammation in patients with active rheumatoid arthritis (RA) and to compare semiquantitative US scoring with quantitative US ..
  19. ncbi Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
    X Ayral
    Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
    Osteoarthritis Cartilage 13:361-7. 2005
    To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage.
  20. ncbi Lymphoid neogenesis in rheumatoid synovitis
    S Takemura
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 167:1072-80. 2001
    ....
  21. ncbi Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression
    A K Brown
    Chapel Allerton Hospital, University of Leeds, Leeds, UK
    Arthritis Rheum 54:3761-73. 2006
    ..This questions the validity of current methods of assessing remission in RA. The purpose of this study was to test the hypothesis that modern joint imaging improves the accuracy of remission measurement in RA...
  22. ncbi Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonography
    Antonio Manzo
    Division of Rheumatology, Laboratory of Rheumatology, University of Pavia School of Medicine and IRCCS Policlinico San Matteo Foundation, P le Golgi 2, 27100 Pavia, Italy
    Rheumatology (Oxford) 50:1395-400. 2011
    ..To investigate the suitability of power Doppler ultrasonography (PD-US) for the assessment of lymph node (LN) status in RA, evaluating the existence of structural and dynamic modifications in well-characterized stages of the disease...
  23. ncbi Expression of aquaporin 1 (AQP1) in human synovitis
    Ali Mobasheri
    Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Sutton Bonington LE12 5RD, UK
    Ann Anat 192:116-21. 2010
    Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial proliferation (synovitis), articular cartilage and subchondral bone degradation as well as joint swelling...
  24. ncbi Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis
    A Price
    University of Paisley, Paisley, UK
    Arthritis Rheum 56:441-7. 2007
    ..The purpose of this study was to investigate the antiinflammatory potential of the selective AT(1) receptor antagonist losartan, which is currently used for the treatment of cardiovascular disease...
  25. pmc Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis
    Carmen A Ambarus
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arthritis Res Ther 14:R74. 2012
    ..Here, we aimed to evaluate the polarization status of synovial macrophages in spondyloarthritis (SpA) and rheumatoid arthritis (RA)...
  26. ncbi Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography
    Conny J van der Laken
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 58:3350-5. 2008
    ..We undertook this study to investigate whether rheumatoid synovitis can be visualized by PET using the tracer 11C-(R)-PK11195, which binds to peripheral benzodiazepine receptors (..
  27. ncbi Blau syndrome, clinical and genetic aspects
    Paolo Sfriso
    Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy
    Autoimmun Rev 12:44-51. 2012
    ..Clinical and genetic aspects of the familial and the sporadic form of BS will be discussed and focused on. A description of a case study of an Italian family is also included...
  28. ncbi The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells
    Keisuke Maeshima
    University of Occupational and Environmental Health, Japan
    Arthritis Rheum 64:1790-8. 2012
    ..The aim of this study was to examine the effects of tofacitinib in vitro and in vivo in RA, in order to elucidate the role of JAK in the disease process...
  29. ncbi Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction
    Marie Christophe Boissier
    Université Sorbonne Paris Cité, Universite Paris 13, Li2P, EA4222 Bobigny, France
    J Autoimmun 39:222-8. 2012
    ....
  30. pmc EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis
    M A D'Agostino
    Rheumatology Department, Cochin Hospital, Paris, France
    Ann Rheum Dis 64:1703-9. 2005
    ..of inflammation in subjects with chronic painful knee osteoarthritis (OA), as determined by the presence of synovitis or joint effusion at ultrasonography (US); and to evaluate the correlation between synovitis, effusion, and ..
  31. pmc EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility
    P Conaghan
    Rheumatology Department, Cochin Hospital, 27, rue du Faubourg St Jacques, 75014 Paris, France
    Ann Rheum Dis 64:1710-4. 2005
    ..Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression...
  32. ncbi Power Doppler ultrasound, but not low-field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity
    Violaine Foltz
    University of Paris VI and Rheumatology Department, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 64:67-76. 2012
    ..The aim of this study was to compare the ability of ultrasonography and magnetic resonance imaging (MRI) to predict relapse and radiographic progression in these patients...
  33. pmc Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial
    Philip G Conaghan
    Section of Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
    Ann Rheum Dis 72:1287-94. 2013
    ..This randomised, double-blind, placebo-controlled phase IIIb study evaluated the impact of abatacept on MRI pathology as a primary outcome in methotrexate (MTX)-refractory patients with rheumatoid arthritis...
  34. ncbi The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
    F Pessler
    The Children s Hospital of Philadelphia, Division of Rheumatology, Philadelphia, USA
    Ann Rheum Dis 67:1184-7. 2008
    ..To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A)...
  35. ncbi Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression
    Esperanza Naredo
    Hospital Severo Ochoa, Madrid, Spain
    Arthritis Rheum 57:116-24. 2007
    ....
  36. ncbi Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis
    Ari Kobayashi
    Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
    Arch Pathol Lab Med 131:563-70. 2007
    ..Matrix metalloproteinase 3 (MMP-3) is expressed in synovial tissues and involved in cartilage destruction in rheumatoid arthritis and osteoarthritis...
  37. ncbi Active foot synovitis in patients with rheumatoid arthritis: applying clinical criteria for disease activity and remission may result in underestimation of foot joint involvement
    Mihir D Wechalekar
    Queen Elizabeth Hospital and Flinders University, Adelaide, South Australia, Australia
    Arthritis Rheum 64:1316-22. 2012
    ..To determine whether application of criteria for remission in rheumatoid arthritis (RA) may result in underestimation of foot joint involvement among patients in a clinic setting...
  38. ncbi Arthroscopic assessment for intra-articular disorders in residual ankle disability after sprain
    Masato Takao
    Department of Orthopaedic Surgery, Shimane University School of Medicine, 89 1 Enya, Izumo, Shimane 693 8501, Japan
    Am J Sports Med 33:686-92. 2005
    ..After ankle sprain, there can be many causes of disability, the origins of which cannot be determined using standard diagnostic tools...
  39. ncbi Imaging of synovitis in osteoarthritis: current status and outlook
    Daichi Hayashi
    Department of Radiology, Boston University School of Medicine, Boston, MA, USA
    Semin Arthritis Rheum 41:116-30. 2011
    This review article provides an overview of the current state of imaging of synovitis in osteoarthritis (OA), looking at recent advances and controversies and focusing particularly on the application of ultrasound and magnetic resonance ..
  40. ncbi Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis
    Atsushi Hashimoto
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, Japan
    J Rheumatol 34:2144-53. 2007
    ....
  41. pmc Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation
    Eric Boilard
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:4361-6. 2011
    ..In this study, we demonstrate that platelets, and not platelet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin in an autoimmune arthritis model...
  42. ncbi The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study
    Kirsty E Haslam
    Department of Paediatric Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Rheumatology (Oxford) 49:123-7. 2010
    Adult studies have demonstrated that ultrasonography (US) is more sensitive at detecting synovitis than clinical examination...
  43. ncbi Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K
    Jukka Morko
    University of Turku, Turku, Finland
    Arthritis Rheum 52:3713-7. 2005
    ..The availability of transgenic UTU17 mice, which exhibit constitutive overexpression of the cathepsin K gene, prompted us to study possible arthritic changes in their knee joints...
  44. ncbi Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology
    B Volck
    Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark
    Osteoarthritis Cartilage 9:203-14. 2001
    ....
  45. ncbi Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis
    Maxime Dougados
    Medicine Faculty, Rheumatology B Department, Descartes University UPRES EA 4058 APHP, Cochin Hospital, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Ann Rheum Dis 69:828-33. 2010
    To evaluate different global ultrasonographic (US) synovitis scoring systems as potential outcome measures of rheumatoid arthritis (RA) according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) filter.
  46. ncbi MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression
    Pernille Bøyesen
    Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N 0319 Oslo, Norway
    Ann Rheum Dis 70:428-33. 2011
    ..To determine whether MRI and conventional (clinical and laboratory) measures of inflammation can predict 3-year radiographic changes measured by the van der Heijde Sharp score in patients with early rheumatoid arthritis (RA)...
  47. ncbi Power Doppler ultrasonography for assessment of synovitis in the metacarpophalangeal joints of patients with rheumatoid arthritis: a comparison with dynamic magnetic resonance imaging
    M Szkudlarek
    The Danish Research Center of Magnetic Resonance, University of Copenhagen Hvidovre Hospital, Denmark
    Arthritis Rheum 44:2018-23. 2001
    ..9%. CONCLUSION: PDUS was reliable for assessing inflammatory activity in the MCP joints of RA patients, using dynamic MRI as the standard. PDUS and clinical assessment of joint swelling/tenderness were only weakly correlated...
  48. ncbi The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis
    H I Keen
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:651-5. 2008
    ..We aimed to develop a preliminary US hand OA scoring system, initially focusing on relevant pathological features with potentially high reliability...
  49. ncbi Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritis
    Juan D Canete
    Institut Clínic de l Aparell Locomotor, and Unitat d Artritis, Servei de Reumatologia, Hospital Clinic de Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Arthritis Rheum 50:1636-41. 2004
    ..Accordingly, angiogenesis may be an important therapeutic target in PsA. The aim of this study was to analyze the effects of infliximab on angiogenesis in the synovial membrane of patients with PsA who responded to this therapy...
  50. pmc Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Res Ther 7:R359-69. 2005
    ..activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes and/or ..
  51. ncbi Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI
    F W Roemer
    Quantitative Imaging Center QIC, Department of Radiology, Boston University Medical Center, Boston, MA 02118, USA
    Osteoarthritis Cartilage 18:1269-74. 2010
    To describe the anatomical distribution of synovitis and its association with joint effusion on non-enhanced and contrast-enhanced (CE) MRI in patients with knee osteoarthritis (OA).
  52. ncbi Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis
    Sadaf Ashraf
    Arthritis Research UK Pain Centre, Department of Academic Rheumatology, University of Nottingham, Nottingham, UK
    Arthritis Rheum 62:1890-8. 2010
    To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and whether inhibiting this angiogenesis at the onset of persistent inflammation leads to its subsequent resolution.
  53. ncbi Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis
    Paul W Cook
    Department of Dermatology, The Oregon Health Sciences University, Portland, OR, USA
    Exp Dermatol 13:347-56. 2004
    ..mice displayed normal knee joint histology, while 2- to 3-week-old K14-ARGE transgenic mice frequently displayed synovitis, as exemplified by the presence of a mixed leukocytic infiltration, increased vascularization, and enhanced ..
  54. ncbi Quantitative determination of the diagnostic accuracy of the synovitis score and its components
    Elisabeth Slansky
    Medical Faculty Carl Gustav Carus, Technical University of Dresden, Germany
    Histopathology 57:436-43. 2010
    To assess the diagnostic accuracy of a three-component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power.
  55. ncbi Identification of broadly discriminatory tissue biomarkers of synovitis with binary and multicategory receiver operating characteristic analysis
    A Ogdie
    Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Biomarkers 15:183-90. 2010
    ..44). Multicategory ROC analysis ranked Ki-67, subintimal CD68, and CD15 as discriminating best among all six sample groups, and thus identified them as the most broadly applicable markers...
  56. ncbi Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)
    Thierry Marhadour
    Rheumatology Unit, CHU, and University Hospital La Cavale Blanche, Brest, France
    J Rheumatol 37:932-7. 2010
    To evaluate the reproducibility of clinical synovitis assessments in rheumatoid arthritis and the effect of variability on the Disease Activity Score-28 (DAS28).
  57. ncbi Microarray analysis of IL-1beta-stimulated chemokine genes in synovial fibroblasts from human TMJ
    Naomi Ogura
    Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Oral Pathol Med 36:223-8. 2007
    ..Gene expression profile of synovial fibroblasts stimulated with IL-1beta was studied by oligonucleotide microarray analysis to elucidate candidate genes associated with intracapsular pathologic conditions of TMJ...
  58. pmc The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab
    Hilde Berner Hammer
    Dept of Rheumatology, Diakonhjemmet Hospital, Box 23, 0319 Oslo, Norway
    Arthritis Res Ther 13:R178. 2011
    ..Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power Doppler (PD))...
  59. ncbi Low-intensity pulsed ultrasound reduces the inflammatory activity of synovitis
    Tatsuya Nakamura
    Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Ann Biomed Eng 39:2964-71. 2011
    ..membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis...
  60. ncbi Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity state
    Frédérique Gandjbakhch
    Department of Rheumatology, Pitie Salpetriere Hospital, APHP, Universite Paris 6 UPMC, Paris, France
    J Rheumatol 38:2039-44. 2011
    ..Our objective was to determine the MRI characteristics of RA patients in clinical remission or low disease activity (LDA) state...
  61. ncbi An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
    A K Brown
    Leeds Institute of Molecular Medicine, University of Leeds, and Chapel Allerton Hospital, Leeds, UK
    Arthritis Rheum 58:2958-67. 2008
    ..The purpose of this study was to evaluate the long-term significance of subclinical synovitis and its relationship to structural outcome.
  62. pmc The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound
    Maxime Dougados
    Hopital Cochin, Rheumatology, Clinique de Rhumatologie B, Groupe Hospitalier Cochin, Paris 75014, France
    Ann Rheum Dis 72:665-71. 2013
    To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA).
  63. pmc Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial
    Philip G Conaghan
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 70:1968-74. 2011
    ..To evaluate golimumab's effect on MRI-detected inflammation and structural damage in patients with active rheumatoid arthritis (RA) despite methotrexate (MTX)...
  64. pmc Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow
    Jie Li
    University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 65:130-8. 2013
    ..The aim of this study was to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells...
  65. pmc Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints
    M Backhaus
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Germany
    Ann Rheum Dis 61:895-904. 2002
    ..Additionally, to study the course of soft tissue lesions depicted in the initial study in comparison with the clinical findings...
  66. pmc The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis
    Weijia Dong
    Department of Clinical Immunology, State Key Discipline of Cell Biology, Xijing Hospital, Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, Shaanxi, PR China
    Arthritis Res Ther 11:R4. 2009
    ..the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic autoantibodies.
  67. pmc Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis
    Gabriele Simonini
    Azienda Ospedaliero Universitaria Meyer, Florence, Italy
    Arthritis Rheum 65:513-8. 2013
    ....
  68. ncbi MRI comes of age in RA clinical trials
    Charles Peterfy
    Spire Sciences, LLC, San Francisco, California, USA
    Ann Rheum Dis 72:794-6. 2013
    ..than radiographs, but importantly it can measure the upstream drivers of erosions and cartilage loss, synovitis and osteitis...
  69. pmc Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database
    Chikashi Terao
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e59341. 2013
    ..We also found that RA synovitis could be classified into three categories of joints in the correlation analyses: large joints with wrist joints, ..
  70. ncbi Reliability of ultrasonography to detect synovitis in rheumatoid arthritis: a systematic literature review of 35 studies (1,415 patients)
    Peter P Cheung
    Paris Descartes University, Cochin Hospital, Paris, France
    Arthritis Care Res (Hoboken) 62:323-34. 2010
    To perform a systematic review on the reliability of ultrasonographic (US) synovitis detection in rheumatoid arthritis (RA) by B-mode and power Doppler (PD) in image acquisition and still-image interpretation...
  71. ncbi Bone oedema predicts erosive progression on wrist MRI in early RA--a 2-yr observational MRI and NC scintigraphy study
    Kari Palosaari
    Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 50, FIN 90029, Box 50, Oulu, Finland
    Rheumatology (Oxford) 45:1542-8. 2006
    ..To investigate if disease assessment by contrast-enhanced dynamic and static magnetic resonance imaging (MRI) and quantitative nanocolloid (NC) scintigraphy gives useful additional information in early rheumatoid arthritis (RA)...
  72. ncbi Magnetic resonance imaging in rheumatoid arthritis clinical trials: emerging patterns based on recent experience
    Charles G Peterfy
    Spire Sciences, LLC, San Francisco, CA, USA
    J Rheumatol 38:2023-30. 2011
    ..In this study, we pool MRI data from randomized controlled clinical trails (RCT) to determine which combination of MCP and wrist joints are most sensitive and discriminative for structural changes over time...
  73. ncbi The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis
    Dirk Wernicke
    Medical Center for Rheumatology Berlin Buch, Karowerstr 11, Berlin 13 125, Germany
    Autoimmunity 39:307-13. 2006
    ..analysis of the synovial tissue is important to distinguish rheumatoid arthritis (RA) from other forms of synovitis and to provide information about prognosis and therapeutic strategies at early stages of the disease...
  74. pmc Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
    Frank W Roemer
    Department of Radiology, Boston University Medical Center, FGH Building, 3rd Floor, 820 Harrison Avenue, Boston, MA 02118, USA
    Ann Rheum Dis 70:1804-9. 2011
    To evaluate if two different measures of synovial activation, baseline Hoffa synovitis and effusion synovitis, assessed by MRI, predict cartilage loss in the tibiofemoral joint at 30 months follow-up in subjects with neither cartilage ..
  75. ncbi Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
    R Torres
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA
    Ann Rheum Dis 68:1602-8. 2009
    ..However, consequences of IL1 inhibition have not been explored in more clinically relevant models of crystal-induced arthritis...
  76. ncbi A comparison of clinical vs ultrasound determined synovitis in rheumatoid arthritis utilizing gray-scale, power Doppler and the intravenous microbubble contrast agent 'Sono-Vue'
    J D Rees
    Department of Rheumatology, St George s Healthcare NHS Trust, London, UK
    Rheumatology (Oxford) 46:454-9. 2007
    b>Synovitis in rheumatoid arthritis (RA) is assessed clinically by the presence of joint tenderness and swelling...
  77. pmc Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat
    E Ekundi-Valentim
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Br J Pharmacol 159:1463-74. 2010
    ..This study was undertaken to evaluate the ability of endogenous and exogenous H(2)S to modulate carrageenan-induced synovitis in the rat knee.
  78. ncbi No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study
    Uffe Møller Døhn
    Department of Rheumatology, Copenhagen University Hospitals at Hvidovre and Glostrup, Hvidovre, Denmark
    Ann Rheum Dis 70:252-8. 2011
    ..To assess the predictive value of MRI and ultrasonography for erosive progression on CT and compare MRI/ultrasonography/radiography for erosion detection/monitoring...
  79. ncbi Temporomandibular joint pain: relationship to internal derangement type, osteoarthrosis, and synovial fluid mediator level of tumor necrosis factor-alpha
    R Emshoff
    University of Innsbruck, Department of Oral and Maxillofacial Surgery, Austria
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:442-9. 2000
    ..was to investigate whether patients with temporomandibular joint (TMJ)-related pain classified as capsulitis/synovitis may be linked to magnetic resonance imaging (MRI) findings of internal derangement, osteoarthrosis, or the ..
  80. ncbi Imaging of osteoarthritis: update from a radiological perspective
    Ali Guermazi
    Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Rheumatol 23:484-91. 2011
    ..To assist investigators in choosing the appropriate imaging technique for a particular goal of a study, this review describes, from a radiological point of view, key studies that were published between May 2010 and May 2011...
  81. ncbi Magnetic resonance imaging findings of internal derangement, osteoarthrosis, effusion, and bone marrow edema before and after performance of arthrocentesis and hydraulic distension of the temporomandibular joint
    Rüdiger Emshoff
    Department of Oral and Maxillo Facial Surgery, University Clinic of Innsbruck, Innsbruck, Austria
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:784-90. 2006
    To investigate whether temporomandibular joint (TMJ) internal derangement type III and capsulitis/synovitis are related to magnetic resonance imaging (MRI) diagnoses of internal derangement, osteoarthrosis (OA), effusion, and/or bone ..
  82. ncbi Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patients
    Mikkel Østergaard
    Department of Rheumatology, Copenhagen University Hospital at Glostrup, Glostrup, Denmark
    Arthritis Rheum 63:3712-22. 2011
    ..To evaluate the effects of golimumab on inflammation/structural damage detected by magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA)...
  83. ncbi Subintimal Ki-67 as a synovial tissue biomarker for inflammatory arthropathies
    F Pessler
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 67:162-7. 2008
    ..We evaluated subintimal Ki-67+ cell density as a tissue biomarker for inflammatory arthropathies and compared it to subintimal CD68, a synovial biomarker of RA...
  84. pmc An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas
    M Østergaard
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Ann Rheum Dis 64:i3-7. 2005
    ..With this atlas, MRIs of wrist and metacarpophalangeal joints of patients with rheumatoid arthritis can be scored for synovitis, bone oedema, and bone erosion, guided by standard reference images.
  85. ncbi A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
    J Song
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea
    Eur J Nucl Med 28:489-97. 2001
    ..study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA)...
  86. ncbi High prevalence of ultrasonographic synovitis and enthesopathy in patients with psoriasis without psoriatic arthritis: a prospective case-control study
    Esperanza Naredo
    Department of Rheumatology, Hospital Universitario Severo Ochoa, 28033 Madrid, Spain
    Rheumatology (Oxford) 50:1838-48. 2011
    To investigate the presence of synovitis, tenosynovitis and enthesitis with power Doppler (PD) ultrasonography (US) in patients with psoriasis without musculoskeletal diseases as compared with controls with other skin diseases without ..
  87. ncbi Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus
    Y Kawaguchi
    Department of Orthopaedic Surgery, Kagawa Medical University, Kita gun, Japan
    Mod Pathol 13:1086-91. 2000
    To clarify the condition of development of synovitis associated with intraarticular osteoid osteoma (OO), expressions of cyclooxygenase-2 (COX-2) protein and its messenger ribonucleic acid were investigated both in the nidus and the ..
  88. ncbi Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis
    Sylvain Breton
    Unit of Radiology, CHU Brest, Universite de Bretagne Occidentale, Faculte de Medecine et des Sciences de la Sante, Brest, France
    Semin Arthritis Rheum 41:272-8. 2011
    The characteristics of synovitis in juvenile idiopathic arthritis (JIA) are important to evaluate, as they define several clinical categories. The metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints are frequently involved...
  89. pmc Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis
    Andrew Filer
    Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 70:500-7. 2011
    ..This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis.
  90. ncbi The role of IFN regulatory factor-1 in synovitis and nitric oxide production
    A Shiraishi
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    J Immunol 159:3549-54. 1997
    ..These results indicate that IRF-1 has a tissue-specific role in the induction of iNOS. Inhibition of this transcription factor may represent a novel approach in controlling inflammatory diseases such as arthritis...
  91. pmc Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proin
    Hyun Mi Choi
    East West Bone and Joint Research Institute, East West Neo Medical Center, Kyung Hee University, 149 Sangil dong, Gangdong gu, Seoul, 134 727, Republic of Korea
    Arthritis Res Ther 11:R161. 2009
    ....
  92. ncbi CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis
    Sanna Rosengren
    Division of Rheumatology, Department of Medicine, Allergy and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, Mail Code 0656, La Jolla, CA 92093 0656, USA
    Rheumatology (Oxford) 50:603-10. 2011
    The B-cell chemokine, CXCL13, is a proposed serum biomarker of synovitis in RA. Its behaviour in the context of B-cell depletion therapy and reconstitution was studied during treatment of RA with rituximab.
  93. ncbi Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients
    Pernille Bøyesen
    Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
    Ann Rheum Dis 70:176-9. 2011
    ..To examine the associations between modern imaging modalities and joint damage measured as 1-year MRI erosive progression, in early rheumatoid arthritis (RA) patients...
  94. ncbi Remitting seronegative symmetrical synovitis with pitting oedema: a study of 12 cases
    S Paira
    Hospital José M Cullen, Santa Fe, Argentina
    Clin Rheumatol 21:146-9. 2002
    Twelve patients with remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) were analysed. Eight of them had typical RS3PE without underlying disease, and four presented associated neoplasia...
  95. ncbi Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice
    Yasuo Niki
    Department of Orthopedic Surgery, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 172:577-84. 2004
    ..These results suggest that MA-IL-1 contributes to synoviocyte self-proliferation and subsequent cartilage destruction in inflammatory joint disease such as rheumatoid arthritis...
  96. ncbi Targeted ultrasound of the fifth metatarsophalangeal joint in an early inflammatory arthritis cohort
    Barry J Sheane
    St James s Hospital, Dublin, Ireland
    Arthritis Rheum 61:1004-8. 2009
    ..The earlier detection of erosion may facilitate the timely initiation of disease-modifying antirheumatic drug therapy, particularly in patients with undifferentiated synovitis.
  97. ncbi Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies
    Elli Kruithof
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 52:3898-909. 2005
    ..may have distinct immunomodulatory effects on specific disease manifestations, the present study was carried out to investigate the immunomodulating effects of etanercept on peripheral synovitis in the spondylarthropathies (SpA).
  98. ncbi The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis
    C L Peters
    University of Bath, Bath, UK
    Arthritis Rheum 50:291-6. 2004
    ..Adjuvant-induced arthritis (AIA) was used as the model system, since it mirrors many aspects of the pathology of rheumatoid arthritis...
  99. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Future directions in the research and treatment of osteoarthritis (OA) will be based on the emerging picture of pathophysiological events that modulate the initiation and progression of OA...
  100. ncbi Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone
    Patrick Durez
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium
    Arthritis Rheum 56:3919-27. 2007
    ..MTX), alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab, on magnetic resonance imaging (MRI)-detected synovitis, bone edema, and erosive changes in patients with early rheumatoid arthritis (RA).
  101. ncbi Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis
    Silvia Magni-Manzoni
    Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Arthritis Rheum 61:1497-504. 2009
    To compare clinical evaluation and ultrasonography (US) in the assessment of joint synovitis in children with juvenile idiopathic arthritis (JIA).

Research Grants62

  1. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    ..This systemic disease is characterized by chronic synovitis, sustained by an antigen-driven immune process against one or more proteins found in cartilage...
  2. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..Together, these studies have the potential to identify a previously unrecognized cellular contributor to synovitis and to begin to unravel the mechanisms underlying the ability of megakaryocytes to participate in a systemic ..
  3. The Role of MicroRNA in Rheumatoid Arthritis Pathogenesis
    Hiroshi Asahara; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE. Rheumatoid arthritis (RA) is characterized by chronic synovitis and subsequent cartilage and bone destruction;however, its etiology and precise pathogenetic mechanisms remain ..
  4. Cadherin-11 growth factor receptor interactions in RA fibroblast hyperplasia
    ERIKA HEIDI NOSS; Fiscal Year: 2013
    ..Aim 3 demonstrates the relevance of cad11 PDGFR interactions to synovitis development by using a mouse inflammatory arthritis model to examine the effect of loss of cad11 expression on ..
  5. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..Therefore, we have set out to determine which factors present during synovitis are capable of suppressing osteoclastogenesis, and to determine their mechanisms of action...
  6. Role of CCR7 in Clinical Response in Inflammatory Arthritis
    Richard M Pope; Fiscal Year: 2013
    ..Additionally, CCR7 deficient mice demonstrate more chronic immune complex mediated arthritis, and the synovitis is highly enriched in macrophages...
  7. Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
    Tuhina Neogi; Fiscal Year: 2013
    ..relation of: 1) central sensitization to pain post-KR;2) the duration and severity inflammatory features of OA (synovitis, effusion) as well as inflammatory mediators that may act locally or systemically (TNF-[unreadable], adiponectin,..
  8. B cells and draining lymph node function in arthritic flair
    Edward M Schwarz; Fiscal Year: 2013
    ..An unexpected finding was that LN collapse appears to preceded the onset of knee synovitis and focal erosions, and that preliminary studies showed that both anti-CD20 and anti-CXCL13 treatment of TNF-Tg ..
  9. UNIQUE SURFACE STRUCTURES ON SYNOVIAL CELLS
    DAVID ALAN FOX; Fiscal Year: 2011
    ..and even fatal immune-mediated disease, in which the major manifestation is typically chronic, polyarticular synovitis that leads to destruction of cartilage and bone, with ensuing joint deformity and dysfunction...
  10. "Mechanisms of IL-35 Protection Against Arthritis"
    David W Pascual; Fiscal Year: 2011
    ..by applicant): Rheumatoid arthritis (RA), a chronic inflammatory disease of the joints, manifests as a chronic synovitis and progressive destruction of the joints, leukocyte infiltrates, and cartilage destruction and bone erosion...
  11. Physiology of Inflammatory Arthritis in High Resolution
    Xueding Wang; Fiscal Year: 2013
    ..More interestingly, we will explore the potential of SPAT in assessing new physiological biomarkers of synovitis including hyperemia and hypoxia...
  12. USE OF THERMAL AND 3D IMAGING TO QUANTIFY ARTHRITIS
    Raphael Hirsch; Fiscal Year: 2010
    ..It has recently been reported that patients in clinical remission often have MRI evidence of continued synovitis, demonstrating that current clinical measures of inactivity do not correlate well with true remission...
  13. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2013
    ..through which pathways adoptively transferred CD8+CCR7+ Tregs suppress the inflammatory activity of rheumatoid synovitis. Finally, we will explore how CD8+CCR7+ Tregs communicate with adjacent CD4 T cells and seek to identify ..
  14. Autoimmunity to ECGF in Lyme disease and its post-infectious syndromes
    Allen C Steere; Fiscal Year: 2012
    ..We have studied this problem previously in patients with Lyme arthritis who have persistent synovitis for months or years after spirochetal killing with antibiotics, called antibiotic-refractory Lyme arthritis...
  15. Effect of Intra-Articular Steroids on Structural Progression of Knee OA: An RCT
    Timothy E McAlindon; Fiscal Year: 2013
    ..that they might influence OA progression is new, and derives from the recent observation of a high prevalence of synovitis in OA knees...
  16. Autoimmunity to ECGF in Lyme disease and its post-infectious syndromes
    Allen C Steere; Fiscal Year: 2013
    ..In recent years, we have studied this problem intensively in patients with Lyme arthritis in whom synovitis persists for months or years after spirochetal killing with antibiotics, called antibiotic-refractory arthritis...
  17. Large-Scale Characterization of Autoantibody Responses in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is an autoimmune synovitis that affects 0.5% of the world population, yet the key autoantigen targets remain unknown...
  18. TAS::75 0888::TAS BIOMEDICAL (APPLIED/EXPLORATORY)
    Kent Kwoh; Fiscal Year: 2010
    ..e., large bone marrow lesions, full thickness cartilage defect, synovial effusion/synovitis, and/or meniscal abnormalities) and altered subchondral bone morphology (i.e...
  19. Cellular and Molecular Effectors of Synovitis
    Paul J Anderson; Fiscal Year: 2010
    ..in macrophage/dendritic cells trigger an immune cascade that induces the expression of IFN-gamma and suppresses synovitis. Project 2 will determine how neutrophil-derived LTB4 targets synovial fibroblasts to promote synovitis...
  20. 99mTc-DTB-Antifol-Pteroyls (RadioDAPs): Theranostics for Rheumatoid Arthritis
    John A Zebala; Fiscal Year: 2011
    ..There is now evidence that active subclinical synovitis and progressive joint destruction occurs in patients despite ongoing drug therapy and apparent clinical ..
  21. Early Aggressive Therapy in Juvenile Idiopathic Arthritis
    Carol Wallace; Fiscal Year: 2009
    ..with JIA have polyarthritis (poly-JIA), which is associated with persistently active disease characterized by synovitis, joint damage, decreased physical functional ability, and a progressive decrease in quality of life...
  22. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2010
    ..is designed to explore the mechanisms through which CD8+CD28~CD56+ T suppressor cells inhibit rheumatoid synovitis and how they can be developed into a novel adoptive immunotherapy for this crippling disease Exploiting the ..
  23. The PRESS ERA: Protein &Resistance Exercise Supplement Study for Elderly with RA
    Rebecca Manno; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovitis and arthritis. The arthritis in RA can be erosive and destructive leading to pain, disability, and deformity...
  24. C5a receptor on mast cells in inflammatory arthritis
    Peter A Nigrovic; Fiscal Year: 2010
    ..provided by applicant): Inflammatory arthritis is a major national health care priority, yet the mechanisms of synovitis remain incompletely understood...
  25. Quantitative 3D Diffusion and Relaxometry MRI of the Knee
    BRIAN ANDREW HARGREAVES; Fiscal Year: 2013
    ..and thickness measurements, T2 and T2* maps and ADC maps, and (3) a non-contrast-enhanced method to assess synovitis. The significance of this proposal is to offer a widely available, quantitatively validated 10-minute imaging ..
  26. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2009
    ..These patients present to emergency departments and manifest an acute traumatic synovitis (TS) secondary to structural defects such as acute anterior cruciate ligament (ACL) injuries following trauma...
  27. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    ..to assess disease progression to joint distortion and spondylitis, and histopathology of affected joints reveals synovitis, pannus formation, and cartilage and bone erosion, which is represented by a validated index...
  28. DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITIS
    Clement Sledge; Fiscal Year: 1992
    ..other joints), our preliminary studies in hemophilic arthropathy of the knee and pigmented villonodular synovitis indicate a high degree of probability that radiation synovectomy will be useful in these disorders as well...
  29. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..controlled trials (RCT) demonstrating efficacy of dietary GLA in patients with rheumatoid arthritis and active synovitis. Ginkbo biloba, a flavonoid-rich extract of leaves of the Ginkbo biloba tree, has been studied in one RCT with ..
  30. OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASES
    ANDREAS HIELSCHER; Fiscal Year: 2007
    ..studies we now believe that three main processes (effusion, erosion, and hypertrophy of the synovial membrane (synovitis)) that accompany RA can be distinguished by optical tomography (OT)...
  31. INCIDENCE & IDENTITY OF THE RA-1 PARVOVIRUS
    Robert Simpson; Fiscal Year: 1990
    ..Synovial fluid and paired blood samples from patients with early synovitis or diagnosed RA will be included in this survey...
  32. Treatment of Early Aggressive Rheumatoid Arthritis TEAR
    Larry Moreland; Fiscal Year: 2001
    ..defined by presence of erosions on hand or feet radiographs, or positive serum rheumatoid factor, plus active synovitis of multiple joints...
  33. LOW DENSITY LIPOPROTEIN AND INFLAMMATION
    Robert Terkeltaub; Fiscal Year: 1993
    ..the extent of modification of oxidized LDL required for it to be proinflammatory in a rat model of acute synovitis (injection into subcutaneous air pouches)...
  34. CLONAL DOMINANCE OF T-LYMPHOCYTES IN ARTHRITIS
    JAMES KURNICK; Fiscal Year: 1991
    ..These studies will draw upon our original observation that synovitis in patients with rheumatoid arthritis (RA) is characterized by the presence of "dominant" T cell clones which ..
  35. RHEUMATOID ARTHRITIS, 1993
    Edward Harris; Fiscal Year: 1993
    ..Factor" (Lipsky), "Overview on Rheumatoid Factor" (Natvig), "The Proliferative Lesion of Rheumatoid Arthritis Synovitis and its Destructive Potential" (Krane), "Determining Prognosis and Disease Activity in Rheumatoid Arthritis" (..
  36. The Relationship of n-3 Fatty Acids with Pain and Synovium in knee OA
    Kristin Baker; Fiscal Year: 2009
    ..In the research plan we propose to investigate a potential nutrition therapy for synovitis and pain in knee osteoarthritis...
  37. N-glycolylneuraminic Acid in the Pathogenesis and Progression of Rheumatoid Arthr
    Nancy Hurtado Ziola; Fiscal Year: 2009
    ..immune complexes in some RA patients, and that such complexes can contribute to the development of inflammatory synovitis. This application shows the presence of Neu5Gc in synovial tissue and fluid and preliminary data on anti-Neu5Gc ..
  38. Adeno-Associated Virus-Mediated Synovial Gene Transfer
    Raphael Hirsch; Fiscal Year: 2006
    ..The effects on synovitis and cartilage destruction of local, versus systemic, expression will be compared...
  39. REGULATION OF CELL ACTIVATION BY FATTY ACIDS
    ROBERT ZURIER; Fiscal Year: 2000
    ..Administration of GLA suppresses joint pain and swelling in RA patients with active synovitis. The means whereby GLA, DGLA and other unsaturated fatty acids influence transduction of activation signals from ..
  40. Pathogenic mechanisms in chlamydial reactive arthritis
    JUDITH WHITTUM HUDSON; Fiscal Year: 2005
    ..Synovial tissue from knees of these animals exhibits histologic signs of synovitis including increased synovial lining cells, dilated vessels, and foci of mononuclear inflammatory cells, and is ..
  41. TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE
    Alun Jones; Fiscal Year: 1999
    ..suitable for radiation synovectomy, particularly for treatment of rheumatoid arthritis and pigmented villonodular synovitis. The use of soluble agents may allow a wider use of this therapy in joints smaller than the knee and ankle.
  42. Treg and Antigen Presentation in Autoimmunity
    Fei Shih; Fiscal Year: 2007
    ..mechanisms whereby systemic T cell autoreactivity can result in diverse disease phenotype from joint centered synovitis to a fulminant multi-organ inflammation...
  43. STATS AND THE PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Lionel Ivashkiv; Fiscal Year: 2000
    ..However, the complexity of cytokine expression has limited analysis of mechanisms by which cytokines regulate synovitis and has limited the identification of the most important cytokines...
  44. SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS
    Kenneth Brandt; Fiscal Year: 1992
    ..The second is a clinical research project, which deals with the importance of synovitis as a cause of pain in OA tasks whether treatment with a nonsteroidal anti-inflammatory drug is more effective in ..
  45. COLLAGEN INDUCED ARTHRITIS--SPECIFICITY OF T CELLS
    Ernest Brahn; Fiscal Year: 1992
    ..Certain lines induce a synovitis when injected intraarticularly (I.A...
  46. RHEUMATOID ARTHRITIS--ADHERENCE INTERVENTION STRATEGIES
    Jacqueline Dunbar Jacob; Fiscal Year: 2002
    ..this population, as pharmacological treatment is directed toward the suppression of inflammation and resulting synovitis and the prevention of disability...
  47. LYMPHOKINES IN RHEUMATOID ARTHRITIS
    Gary Firestein; Fiscal Year: 1991
    The perpetuation of rheumatoid synovitis will be studied in the context of an autologous mixed lymphocyte reaction (AMLR) model...
  48. MECHANISMS OF TISSUE INJURY IN RHEUMATOID ARTHRITIS
    Larry Moreland; Fiscal Year: 2000
    ..central focus of this application is to examine two hypotheses concerning the pathophysiology of inflammatory synovitis in rheumatoid arthritis -- that continual local activation of T cells to produce Th1-like cytokines is the key ..
  49. MOLECULAR GENETIC BASIS OF RF IN RA
    Dick Robbins; Fiscal Year: 1993
    ..b>Synovitis is central to the immunopathologic events in RA, thus it is likely that RF made there are of greater ..
  50. Planing an Early RA Prevention Trial
    David Pisetsky; Fiscal Year: 2005
    ..by Immediate Definitive Therapy) and is designed to determine the impact of DMARD therapy in patients with early synovitis. The study will have 5 arms consisting of patients administered DMARD therapy (methotrexate alone or ..
  51. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..by accumulating in the joints as highly reactive immunocomplexes, play a central role in the pathogenesis of synovitis. The mechanisms underlying the dysregulation of Ig class switching and antibody production in RA patients remain ..
  52. REGULATION OF COLLAGENASE GENE EXPRESSION
    Constance Brinckerhoff; Fiscal Year: 2006
    ..suggest that RA patients with this allele may display heightened MMP-1 expression and particularly erosive synovitis. Thus, the specific aims are to (1) recapitulate the pathogenesis of RA in a rabbit model of polycation-induced ..
  53. REGULATION OF INFLAMMATION IN EXPERIMENTAL ARTHRITIS
    JOHN SCHWAB; Fiscal Year: 1993
    ..test the capacity of several highly purified cytokine or eicosanoid mediators to cause reactivation of erosive synovitis which has been initiated by PG-APS...
  54. Strategies for Evaluating and Treating Early Synovitis
    David Pisetsky; Fiscal Year: 2004
    ..Risk Rheumatic and Musculoskeletal and Skin Diseases Research grant is to develop a strategy for studying early synovitis and provide a framework to test the window-of-opportunity hypothesis in the treatment of rheumatoid arthritis (..
  55. THROMBOSPONDIN AND T CELLS
    ABBE DE VALLEJO; Fiscal Year: 2000
    ..An analysis of CD47-dependent effector functions of CD4+CD28null T cells could provide valuable insights on the role of these unusual cells in the pathogenesis of rheumatoid synovitis.
  56. IDO: A Novel Endogenous Suppressor of Inflammation
    John Varga; Fiscal Year: 2002
    ..The pathogenesis of rheumatoid synovitis involves complex interaction between T lymphocytes, autonomously activated fibroblast-like synovial cells (FLS) ..
  57. MICROVASCULAR MECHANISMS OF ARTICULAR DAMAGE IN ANTIGEN
    Maren Mahowald; Fiscal Year: 1991
    ..with oral coumadin to examine the effects of blocking the initial microvascular occlusion in immune mediated synovitis. 2) AIA rabbits treated with oral heparin to enhance angiogenesis; and 3) AIA rabbits treated with oral heparin ..
  58. Oral Interferon Treatment in collagen induced arthritis
    Patricia Nelson; Fiscal Year: 2003
    ..We hypothesize that IFN/tau will induce a systemic Th2 response in mice sensitized to collagen and reduce synovitis when administered after the onset of overt disease...
  59. T CELL SPECIFICITY AND FUNCTION IN LYME SYNOVITIS
    Michael Vincent; Fiscal Year: 2000
    ..development plan is proposed encompassing laboratory investigations on the role of gamma/delta T cells in Lyme synovitis and a curriculum in immunology, autoimmunity, and the conduct of responsible, clinically relevant research...
  60. DNA VACCINE MEDIATED IMMUNOTHERAPY OF RHEUMATIC DISEASE
    William Robinson; Fiscal Year: 2004
    ..RA is a chronic autoimmune inflammatory synovitis affecting 1 percent of the world population...
  61. CLONALITY AND TCR GENES OF RA AND LYME SYNOVIAL T CELLS
    SHELDON COOPER; Fiscal Year: 1993
    ..such T cells are identified, it is likely that they will be specific for antigens that induce or perpetuate the synovitis. T cells will be cloned immediately from synovial tissue, eliminating the potential for expansion of selected ..
  62. SPECIALIZED CENTER OF RESEARCH IN RHEUMATOID ARTHRITIS
    David Pisetsky; Fiscal Year: 2000
    ..Project 1 will focus on the role of CD44 in mediating adhesive interactions in synovitis and the contribution of CD7 negative T cells in promoting synovial inflammation...