hemarthrosis

Summary

Summary: Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.

Top Publications

  1. ncbi Comparative study of validity of clinical, X-ray and magnetic resonance imaging scores in evaluation and management of haemophilic arthropathy in children
    H Pergantou
    Haemophilia Centre, Haemostasis Unit, Aghia Sophia Children s Hospital, Athens, Greece
    Haemophilia 12:241-7. 2006
  2. ncbi The role of arthroscopic synovectomy in the management of hemarthrosis in hemophilia patients: financial perspectives
    Robert M Tamurian
    Section of Orthopaedic Surgery, the University of Michigan Hospitals and Clinics, Ann Arbor, Michigan 48109 0328, USA
    Arthroscopy 18:789-94. 2002
  3. ncbi Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    Marilyn J Manco-Johnson
    University of Colorado and Health Sciences Center, Denver, USA
    N Engl J Med 357:535-44. 2007
  4. ncbi A prospective magnetic resonance imaging study of the incidence of posterolateral and multiple ligament injuries in acute knee injuries presenting with a hemarthrosis
    Robert F LaPrade
    Sports Medicine and Shoulder Divisions, Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55454, USA
    Arthroscopy 23:1341-7. 2007
  5. ncbi Hemarthrosis of the knees following streptokinase therapy for acute myocardial infarction
    Eduardo Pimenta
    Faculdade de Medicina do ABC Santo Andre, SP, Brazil
    Arq Bras Cardiol 80:641-2, 639-2. 2003
  6. ncbi [Hemarthrosis as a hemorrhagic complication after thrombolytic treatment]
    A Gallardo

    Rev Esp Cardiol 54:1230-2. 2001
  7. ncbi In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair
    Sang Yang Lee
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    J Cell Physiol 210:561-6. 2007
  8. ncbi Recurrent hemarthrosis in a hemophilic patient after revision total knee arthroplasty
    Justin J Park
    Division of Orthopedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA justin park nyumc org
    Orthopedics 33:771. 2010
  9. ncbi A 6-year follow-up of dosing, coagulation factor levels and bleedings in relation to joint status in the prophylactic treatment of haemophilia
    J Ahnström
    Hospital Pharmacy, Malmo University Hospital, Malmo, Sweden
    Haemophilia 10:689-97. 2004
  10. ncbi Association between joint bleeds and Pettersson scores in severe haemophilia
    K Fischer
    Department of Paediatrics, University Medical Centre Utrecht, The Netherlands
    Acta Radiol 43:528-32. 2002

Detail Information

Publications211 found, 100 shown here

  1. ncbi Comparative study of validity of clinical, X-ray and magnetic resonance imaging scores in evaluation and management of haemophilic arthropathy in children
    H Pergantou
    Haemophilia Centre, Haemostasis Unit, Aghia Sophia Children s Hospital, Athens, Greece
    Haemophilia 12:241-7. 2006
    ..Five children, who were already on prophylaxis complied with our recommendations and eliminated haemorrhages. Finally, three boys with severe haemophilic arthropathy in knees underwent successful chemical synovectomy with rifampicin...
  2. ncbi The role of arthroscopic synovectomy in the management of hemarthrosis in hemophilia patients: financial perspectives
    Robert M Tamurian
    Section of Orthopaedic Surgery, the University of Michigan Hospitals and Clinics, Ann Arbor, Michigan 48109 0328, USA
    Arthroscopy 18:789-94. 2002
    ..The purpose of this study was to determine the financial efficacy of arthroscopic synovectomy in hemophilia patients with recurrent hemarthroses...
  3. ncbi Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    Marilyn J Manco-Johnson
    University of Colorado and Health Sciences Center, Denver, USA
    N Engl J Med 357:535-44. 2007
    ..Effective ways to prevent arthropathy in severe hemophilia are unknown...
  4. ncbi A prospective magnetic resonance imaging study of the incidence of posterolateral and multiple ligament injuries in acute knee injuries presenting with a hemarthrosis
    Robert F LaPrade
    Sports Medicine and Shoulder Divisions, Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55454, USA
    Arthroscopy 23:1341-7. 2007
    ..incidence of posterolateral knee injuries, as well as other concurrent knee ligament injuries, could be obtained from a prospective evaluation of magnetic resonance imaging scans in patients with an acute knee injury with a hemarthrosis.
  5. ncbi Hemarthrosis of the knees following streptokinase therapy for acute myocardial infarction
    Eduardo Pimenta
    Faculdade de Medicina do ABC Santo Andre, SP, Brazil
    Arq Bras Cardiol 80:641-2, 639-2. 2003
    A sixty-four-year-old male patient was studied who had acute coronary syndrome with ST segment elevation experienced bilateral hemarthrosis of the knees after administration of streptokinase and acetylsalicylic acid.
  6. ncbi [Hemarthrosis as a hemorrhagic complication after thrombolytic treatment]
    A Gallardo

    Rev Esp Cardiol 54:1230-2. 2001
    ..case of a rare hemorrhagic location after the use of this treatment for acute myocardial infarction, as ankle hemarthrosis. In the first twelve hours the patient had a joint hemorrhagic effusion with refractory pain and arthrocentesis ..
  7. ncbi In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair
    Sang Yang Lee
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    J Cell Physiol 210:561-6. 2007
    ..search for alternative sources of MPCs that could be obtained with minimal invasion, we looked into traumatic hemarthrosis of the knee...
  8. ncbi Recurrent hemarthrosis in a hemophilic patient after revision total knee arthroplasty
    Justin J Park
    Division of Orthopedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA justin park nyumc org
    Orthopedics 33:771. 2010
    Recurrent hemarthrosis following a revision total knee arthroplasty is a rare complication. The likelihood of encountering bleeding complications in patients with hemophilia C following major surgery is unpredictable...
  9. ncbi A 6-year follow-up of dosing, coagulation factor levels and bleedings in relation to joint status in the prophylactic treatment of haemophilia
    J Ahnström
    Hospital Pharmacy, Malmo University Hospital, Malmo, Sweden
    Haemophilia 10:689-97. 2004
    ..Thus, proposed standard regimens should be implemented only after careful clinical consideration, with a high readiness for re-assessment and individual dose tailoring...
  10. ncbi Association between joint bleeds and Pettersson scores in severe haemophilia
    K Fischer
    Department of Paediatrics, University Medical Centre Utrecht, The Netherlands
    Acta Radiol 43:528-32. 2002
    ..To assess and quantify the association of haemophilic arthropathy, measured by the radiological Pettersson score, with the number of joint bleeds suffered by the patient...
  11. ncbi Prophylactic treatment for prevention of joint disease in hemophilia--cost versus benefit
    Goris Roosendaal
    N Engl J Med 357:603-5. 2007
  12. ncbi Life expectancy in hemophilia outcome
    C Mejia-Carvajal
    Department of Pediatrics and the Rush Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Thromb Haemost 4:507-9. 2006
  13. ncbi Prophylaxis for severe haemophilia: clinical challenges in the absence as well as in the presence of inhibitors
    K Fischer
    Van Creveldkliniek, Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 14:196-201. 2008
    ..Data on results of primary prophylaxis in patients with inhibitors to prevent arthropathy are not yet available...
  14. ncbi Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
    B M Feldman
    Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    J Thromb Haemost 4:1228-36. 2006
    ..We studied an inception cohort of 25 boys using a tailored prophylaxis approach to see if clotting factor use could be reduced with acceptable outcomes...
  15. ncbi Effects of secondary prophylaxis started in adolescent and adult haemophiliacs
    A Tagliaferri
    Regional Reference Centre for Inherited Bleeding Disorders, University Hospital, Parma, Italy
    Haemophilia 14:945-51. 2008
    ..With respect to on-demand treatment, higher factor consumption and cost of secondary prophylaxis were balanced by marked clinical benefits and greater well-being in this cohort of adolescent/adult haemophiliacs...
  16. ncbi Clinical and cost implications of target joints in Canadian boys with severe hemophilia A
    Melissa Kern
    Division of Hematology Oncology, The Hospital for Sick Children, Ontario, Canada
    J Pediatr 145:628-34. 2004
    ..To compare target joint-associated costs incurred by boys with severe hemophilia A 1 year before and 1 year after development of a target joint (pre-TJ, post-TJ)...
  17. ncbi Cost-utility analysis of Canadian tailored prophylaxis, primary prophylaxis and on-demand therapy in young children with severe haemophilia A
    N Risebrough
    HOPE Research Centre, Division of Clinical Pharmacology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
    Haemophilia 14:743-52. 2008
    ..In conclusion, prophylaxis will substantially improve clinical outcomes and quality of life compared to Demand treatment, but with substantial cost...
  18. ncbi Understanding haemophilic arthropathy: an exploration of current open issues
    Nathalie W D Jansen
    Rheumatology and Clinical Immunology, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Br J Haematol 143:632-40. 2008
    ..These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa. Consequently, effective treatment strategies will have to affect both pathways...
  19. ncbi Haemophilia care in children--benefits of early prophylaxis for inhibitor prevention
    M E Mancuso
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Milan, Italy
    Haemophilia 15:8-14. 2009
    ..Practical approaches to early prophylaxis as implemented in the haemophilia centres in Milan and Bremen are discussed in this respect...
  20. ncbi Effects of primary and secondary prophylaxis on the clinical expression of joint damage in children with severe haemophilia A. Results of a multicenter non-concurrent cohort study
    Rosemarie Schobess
    Department of Pediatrics, University Hospital Halle, Halle, Germany
    Thromb Haemost 99:71-6. 2008
    ..77). No conclusion can be drawn from the data presented herein whether primary prophylaxis or an early start of secondary prophylaxis is superior with respect to joint outcome in children with severe HA...
  21. ncbi On-demand vs. prophylactic treatment for severe haemophilia in Norway and Sweden: differences in treatment characteristics and outcome
    K Steen Carlsson
    Department of Community Medicine, Malmo University Hospital, and Lund University Centre for Health Economics, Lund University, Lund, Sweden
    Haemophilia 9:555-66. 2003
    ..Differences were consistently substantial and will affect both costs and benefits of the two treatment strategies...
  22. ncbi Prophylactic treatment for severe haemophilia: comparison of an intermediate-dose to a high-dose regimen
    K Fischer
    Department of Paediatrics, University Medical Center Utrecht, The Netherlands
    Haemophilia 8:753-60. 2002
    ....
  23. ncbi Management and prevention of recurrent hemarthrosis in patients with hemophilia
    Amy L Dunn
    Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University and Children s Healthcare of Atlanta, GA 30322, USA
    Curr Opin Hematol 12:390-4. 2005
    Degenerative arthropathy resulting from recurrent hemarthrosis remains the largest source of noninfectious morbidity for persons with hemophilia. Optimal treatment to prevent or reduce joint destruction remains controversial.
  24. ncbi Hemophilic arthropathy
    James V Luck
    Orthopaedics Hemophilia Treatment Center, Orthopaedic Hospital, Los Angeles, CA 90007, USA
    J Am Acad Orthop Surg 12:234-45. 2004
    ..Despite the medical and surgical complexities of hemophilic arthropathy, orthopaedic procedures have a high incidence of patient satisfaction...
  25. ncbi Evaluation of bone mineral density in children with hemophilia: Mansoura University children hospital (MUCH) experience, Mansoura, Egypt
    Nabil Abdelrazik
    Mansoura Faculty of Medicine, Mansoura University Children s Hospital, Masnoura, Egypt
    Hematology 12:431-7. 2007
    ..Patients with hemophilia may be at risk for developing reduced bone mineral density (BMD) for a number of reasons such as recurrent hemoarthrosis and immobilization...
  26. ncbi Assessment of treatment practice patterns for severe hemophilia A: a global nurse perspective
    Kate Khair
    Great Ormond Street Hospital for Children NHS Trust, London, UK
    Acta Haematol 119:115-23. 2008
    ..They cited patient/family education as the most appropriate strategy for overcoming the barriers to prophylaxis...
  27. doi Including the life-time cumulative number of joint bleeds in the definition of primary prophylaxis
    Ingrid E M den Uijl
    Thromb Haemost 99:965; author reply 966-8. 2008
  28. ncbi Isotopic synovectomy with P-32 in paediatric patients with haemophilia
    P Mathew
    Department of Pediatrics, Medical College of Ohio Hospital, Toledo, Ohio, USA
    Haemophilia 6:547-55. 2000
    ..As previously shown, MRI appears to give more detailed information about joint arthropathy than plain radiographs...
  29. ncbi Therapeutic embolization of the genicular arteries for recurrent hemarthrosis after total knee arthroplasty
    M Katsimihas
    Department of Orthopaedic Surgery, Avon Orthopaedic Centre, Southmead Hospital, Bristol, United Kingdom
    J Arthroplasty 16:935-7. 2001
    The case of a recurrent hemarthrosis initially presenting 30 months after a total knee arthroplasty in a patient on lifelong warfarin is described...
  30. ncbi Current situation of regular replacement therapy (prophylaxis) for haemophilia in Japan
    M Taki
    Department of Pediatrics, St Marianna University School of Medicine Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan
    Haemophilia 15:78-82. 2009
    ..In addition, the fear of inhibitor development, as well as the psychological anxiety in paediatric patients, was also mentioned as barriers to initiating and continuing prophylaxis...
  31. ncbi Experimental haemophilic synovitis: rationale and development of a murine model of human factor VIII deficiency
    L A Valentino
    Departments of Pediatrics and Immunology Microbiology, Rush Children s Hospital and Rush University, Chicago, IL 60612, USA
    Haemophilia 10:280-7. 2004
    ..microscopic and ultrastructural changes that occur in the synovial membrane following human and experimental hemarthrosis have been described...
  32. ncbi Spontaneous hemarthrosis 6 years after total knee arthroplasty
    R B Cunningham
    Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Arthroplasty 16:133-5. 2001
    Spontaneous hemarthrosis is an uncommon complication of total knee arthroplasty...
  33. ncbi Modern management of haemophilic arthropathy
    Leslie Raffini
    Division of Hematology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Br J Haematol 136:777-87. 2007
    ..Patients with high titre inhibitors are at great risk for the development of joint disease and present the greatest therapeutic challenges when joint surgery is needed...
  34. ncbi Hemophilic arthropathy: considerations in management
    T J Chang
    California College of Podiatric Medicine, USA
    J Am Podiatr Med Assoc 91:406-14. 2001
    ..The authors recommend that proper conservative and surgical management options for patients with hemophilia should be based upon a thorough understanding of the disease process...
  35. ncbi Modified magnetic resonance imaging score compared with orthopaedic and radiological scores for the evaluation of haemophilic arthropathy
    M B Funk
    Department of Paediatrics III, J W Goethe University, Frankfurt, Germany
    Haemophilia 8:98-103. 2002
    ..In addition, the modified MRI score seems to differentiate better between early and advanced signs of arthropathy than the MRI scale of Nuss et al...
  36. ncbi Local vascular complications after knee replacement: a review with illustrative case reports
    V G Langkamer
    Weston General Hospital, Weston Super Mare, N Somerset
    Knee 8:259-64. 2001
    ..If doubt exists, a vascular opinion should be obtained before knee replacement. In the event of a vascular complication occurring, serious morbidity can be avoided by prompt diagnosis, investigation and specialist treatment...
  37. ncbi Spontaneous recurrent haemarthrosis following unicompartmental knee arthroplasty and its successful treatment by coil embolisation
    R Maheshwari
    Avon Orthopaedic Centre, Southmead Hospital, Bristol, BS10 5NB, UK
    Knee 11:413-5. 2004
    ..Since the embolisation, the haemarthrosis has not recurred. To our knowledge, this therapeutic procedure used to treat recurrent haemarthrosis following unicondylar knee arthroplasty has not been previously described in the literature...
  38. ncbi Late spontaneous haemarthrosis: an unusual complication following an unicompartmental knee arthroplasty
    Jan De Raet
    Department of Orthopaedic and Trauma Surgery, St Nikolaus Hospital Eupen, Hufengasse 4, 4700 Eupen, Belgium
    Knee Surg Sports Traumatol Arthrosc 15:763-5. 2007
    ..This is a rare but destructive complication following an unicompartmental knee arthroplasty...
  39. ncbi The use of prophylaxis in 2663 children and adults with haemophilia: results of the 2006 Canadian national haemophilia prophylaxis survey
    T T Biss
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Haemophilia 14:923-30. 2008
    ..Prophylaxis is being started earlier in boys with severe haemophilia A...
  40. ncbi Hemarthrosis after trauma to the pediatric knee joint: what is the value of magnetic resonance imaging in the diagnostic algorithm?
    L M Wessel
    Kinderchirurgische Klinik, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    J Pediatr Orthop 21:338-42. 2001
    In children, compulsory arthroscopy for hemarthrosis after knee trauma is not justified because ligamentous and meniscal damage is rare...
  41. ncbi Is corticosteroid coinjection necessary for radiosynoviorthesis of patients with hemophilia?
    Gonca Kara Gedik
    Departments of Nuclear Medicine, Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey
    Clin Nucl Med 29:538-41. 2004
    ....
  42. ncbi The target joint
    K Mulder
    Physiotherapy, Child Health, and Bleeding Disorders Clinic, Health Sciences Center, Winnipeg, Canada
    Haemophilia 10:152-6. 2004
    ..The target ankle joint is a special challenge as it often develops in very young children when the articular cartilage is susceptible and compliance with conservative treatment is difficult...
  43. ncbi Optimizing factor prophylaxis for the haemophilia population: where do we stand?
    V S Blanchette
    Division of Hematology Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada
    Haemophilia 10:97-104. 2004
    ..Such studies should incorporate outcome measures such as health-related quality-of-life and economic analyses...
  44. ncbi Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group
    A S Doria
    The Hospital for Sick Children, Diagnostic Imaging, Toronto, ON, Canada, and University Hospital of Lund, Radiology, Sweden
    Haemophilia 12:503-13. 2006
    ..Compared with radiographic scores, the MRI scales performed better for discrimination of early osteoarticular changes...
  45. ncbi Arthroscopic synovectomy for hemophilic joint disease in a pediatric population
    Amy L Dunn
    Department of Pediatrics, AFLAC Cancer and Blood Disorders Center at Children s Healthcare of Atlanta Emory University, Atlanta, Georgia, USA
    J Pediatr Orthop 24:414-26. 2004
    ..Complications were rare. Radiographic scores worsened slightly. In this largest analysis of arthroscopic synovectomy for children with hemophilia, rehabilitation was not problematic...
  46. ncbi Dose and response in haemophilia--optimization of factor replacement therapy
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, India
    Br J Haematol 127:12-25. 2004
    ..Less intensive protocols could achieve similar outcomes. Large multi-centre prospective studies are needed to provide comparative data on unresolved issues so that factor replacement therapy can be optimized, based on evidence...
  47. ncbi Successful use of ReFacto continuous infusion in two paediatric patients with severe haemophilia A undergoing orthopaedic surgery
    M M Sennett
    Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    Haemophilia 10:655-60. 2004
    ..Patient 2 received an additional bolus dose of 15 IU kg(-1) during the infusion period. All procedures were performed without haemostatic complications and long-term orthopaedic outcomes were good in both patients...
  48. ncbi The haemophilic ankle
    E C Rodriguez-Merchan
    La Paz University Hospital, Madrid, Spain
    Haemophilia 12:337-44. 2006
    ..Primary prophylaxis and radioactive synoviorthesis are the best ways that we have today of protecting against haemophilic synovitis and arthropathy of the ankle joint...
  49. ncbi Prevention of haemophilic synovitis: prophylaxis
    C A Lee
    University of London, Oxford Haemophilia Centre, Oxford, UK
    Haemophilia 13:20-5. 2007
    ....
  50. pmc Arthroscopic synovectomy in haemophilic arthropathy of the knee
    Kyoung Ho Yoon
    Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, 1 Hoiki Dong, Seoul, 130 702, South Korea
    Int Orthop 29:296-300. 2005
    ..An arthroscopic synovectomy of the knee using appropriate arthroscopic portals is a useful method in treating haemophilic patients as it decreases bleeding episodes, amount of factor replacement and knee pain...
  51. ncbi Pathogenesis of haemophilic synovitis: clinical aspects
    W K Hoots
    Gulf States Haemophilia and Thrombophilia Center, The University of Texas Health Science Center, Houston, TX 77030, USA
    Haemophilia 13:4-9. 2007
    ..Randomized, clinical trials are needed to provide the answers regarding the optimal treatment of patients with severe haemophilia...
  52. ncbi An approach to target joint bleeding in hemophilia: prophylaxis for all or individualized treatment?
    Thomas Abshire
    J Pediatr 145:581-3. 2004
  53. ncbi A cost minimization model for the treatment of minor bleeding episodes in patients with haemophilia A and high-titre inhibitors
    K G Putnam
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Haemophilia 11:261-9. 2005
    ..Sensitivity analyses over a range of clinically plausible values for cost, dosing, and efficacy did not change the selection of aPCC as the dominant strategy...
  54. ncbi Prophylactic recombinant factor VIIa in haemophilia patients with inhibitors
    G Young
    Department of Pediatric Hematology, Children s Hospital of Orange County, Orange, CA 92868, USA
    Haemophilia 11:203-7. 2005
    ..Both patients had an outstanding response to prophylaxis albeit at a very high cost. Prophylaxis with rFVIIa can be an effective approach in select inhibitor patients with severe complications related to bleeding...
  55. ncbi Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy
    B Lundin
    Department of Radiology, University Hospital of Lund, Lund, Sweden
    Haemophilia 11:109-15. 2005
    ..The use of these two compatible scales for progressive and additive MRI assessments can facilitate international comparison of data and enhance the accumulation of experience on MRI scoring of haemophilic arthropathy...
  56. ncbi Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the Hemophilia and Thrombosis Research Society Registry
    R Parameswaran
    Indiana Hemophilia and Thrombosis Center, IN, USA
    Haemophilia 11:100-6. 2005
    ..Recombinant FVIIa appears to have a wide safety margin that may allow dose escalation to address these questions...
  57. ncbi Variability in clinical phenotype of severe haemophilia: the role of the first joint bleed
    K van Dijk
    Van Creveldkliniek, UMC Utrecht, Utrecht, The Netherlands
    Haemophilia 11:438-43. 2005
    ..Thus, providing a starting point for aetiological research and individualization of treatment...
  58. ncbi Prophylactic treatment effects on inhibitor risk: experience in one centre
    M Morado
    Congenital Coagulopathy Section, Haematology Service, Universitary Hospital La Paz, Madrid, Spain
    Haemophilia 11:79-83. 2005
    ....
  59. ncbi A modular total knee arthroplasty in haemophilic arthropathy
    M Innocenti
    Second Orthopaedic Clinic, University of Florence C T O Largo Palagi 1, 50139, Florence, Italy
    Knee 14:264-8. 2007
    ..001). The results of our study confirm that the introduction of modular design may improve the functional results of TKA in haemophilic arthropathy which results in a better range of motion and lower flexion contracture...
  60. ncbi MRI scores of ankle joints in children with haemophilia--comparison with clinical data
    B Lundin
    Department of Radiology, University Hospital of Lund, Lund, Sweden
    Haemophilia 11:116-22. 2005
    ..The European scoring method differentiates the arthropathic changes further than the Denver scale does, but the two different scoring methods have similar correlation to the number of joint bleeds and the orthopaedic joint score...
  61. ncbi Outcome of surgical concepts in haemophilic arthropathy of the hindfoot
    J Panotopoulos
    Department of Orthopaedics, Medical University of Vienna, Vienna, Austria
    Haemophilia 11:468-71. 2005
    ..If synovectomy fails, the arthrodesis proves to be a good treatment option...
  62. ncbi Total knee replacement in haemophilic arthropathy
    E C Rodriguez-Merchan
    Department of Orthopaedics and Haemophilia Unit, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain
    J Bone Joint Surg Br 89:186-8. 2007
    ..Our rate of infection was lower than previously reported. This could be due to better control of the HIV status with highly active anti-retroviral therapy and the use of antibiotic-loaded cement...
  63. ncbi Long-term evaluation of radioisotope synovectomy with Yttrium 90 for chronic synovitis in Turkish haemophiliacs: Izmir experience
    K Kavakli
    Department Pediatric Hematology, Ege University Hospital, Ege Hemophilia Centre Bornova, Izmir, Turkey
    Haemophilia 12:28-35. 2006
    ..There was a minimal radioisotope leakage to superficial skin in the elbow. RS seems to be a safe and effective treatment for chronic synovitis causing recurrent joint bleedings...
  64. ncbi [The orthopaedic status of a selected severe haemophilia group]
    Jerzy Windyga
    Samodzielna Pracownia Krzepniecia Krwi i Hemostazy Instytutu Hematologii i Transfuzjologii w Warszawie
    Pol Arch Med Wewn 113:562-9. 2005
    ..This disabling complication of severe haemophilia can be prevented only by introducing primary prophylaxis from the first years of life...
  65. ncbi Dose and outcome of care in haemophilia--how do we define cost-effectiveness?
    K Fischer
    Van Creveldkliniek, University Medical Centre Utrecht, The Netherlands
    Haemophilia 10:216-20. 2004
    ..Can the data on outcome at different levels of factor replacement be used to assess their cost-effectiveness?..
  66. ncbi Prospective controlled studies on prophylaxis: an Italian approach
    A Gringeri
    Haemophilia and Thrombosis Centre, Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Haemophilia 9:38-42; discussion 43. 2003
    ....
  67. ncbi Long-term FEIBA prophylaxis does not prevent progression of existing joint disease
    M W Hilgartner
    New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY, USA
    Haemophilia 9:261-8. 2003
    ..Efficacy to prevent arthropathy could not be seen as all patients had some degree of arthropathy at time of prophylaxis initiation. An additional study needs to be performed using FEIBA before arthropathy has developed...
  68. ncbi [Pattern of type A hemophilia in Senegal: prospective study in 54 patients]
    S Diop
    Centre National de Transfusion Sanguine, BP 5002, Dakar Fann, Senegal
    Transfus Clin Biol 10:37-40. 2003
    ..6%, moderate form was 55.6% and minor form 14.8%. Total number of hemorrhage events was 1078 per year: 449 hemarthrosis (41.7%), 373 exteriorized hemorrhage (34.7%) and 256 hematomas (23.7%)...
  69. ncbi [Evaluation of haemophilic arthropathy--a comparison of MRI and Pettersson score]
    M B Funk
    Kinderradiologie, Zentrum der Radiologie, Germany
    Rofo 174:314-20. 2002
    ..In order to compare score values, joint alterations in haemophilic patients on early and late prophylaxis were assessed and evaluated by X-ray radiography and magnetic resonance imaging (MRI) in a prospective study...
  70. ncbi Value of magnetic resonance imaging for the diagnosis and follow-up of haemophilic arthropathy
    M Dobon
    Department of Haematology, Hospital Miguel Servet, Zaragoza, Spain
    Haemophilia 9:76-85. 2003
    ..320). MRI is a precise non-invasive tool for the assessment of early joint cartilage and synovium pathological changes still undetectable by physical examination or conventional X-rays in the haemophilic setting...
  71. ncbi Long-term follow-up after osteotomy for haemophilic arthropathy of the knee
    T Wallny
    Department of Orthopaedics, University of Bonn, Bonn, Germany
    Haemophilia 9:69-75. 2003
    ..Particularly the younger patient can benefit from this treatment option in that joint replacement may possibly wholly be avoided or at least postponed to a later stage of life...
  72. ncbi Aspects of haemophilia prophylaxis in Sweden
    R C R Ljung
    Department of Paediatrics, Lund University, University Hospital, Malmo, Sweden
    Haemophilia 8:34-7. 2002
    ....
  73. ncbi Intra-articular rifamycin in haemophilic arthropathy
    P Radossi
    Haemophilia Centre, Castelfranco Veneto Hospital TV, Regione Veneto, Italy
    Haemophilia 9:60-3. 2003
    ..The procedure presents a low risk of bleeding, can be used for patients with inhibitors and multiple joints can be treated without any additional cost...
  74. ncbi Effects of prophylactic treatment regimens in children with severe haemophilia: a comparison of different strategies
    H M Van den Berg
    Van Creveldkliniek, Department of Paediatrics, Julius Centre for Patient Oriented Research, University Medical Centre, Utrecht, The Netherlands
    Haemophilia 8:43-6. 2002
    ..In conclusion, more individually tailored regimens aimed at preventing bleeding prevent joint damage in children with severe haemophilia, while clotting factor consumption is about half of that in previously described regimens...
  75. ncbi Cost and outcome: comparisons of two alternative bypassing agents for persons with haemophilia A complicated by an inhibitor
    Katarina Steen Carlsson
    Lund University Centre for Health Economics, LUCHE, Lund, Sweden
    Thromb Haemost 99:1060-7. 2008
    ..The large individual-level variation in reduction of pain supports decisions that consider the individual patient's experience and that accept trade-offs between cost and reduction in pain rather than focusing on cost only...
  76. ncbi Orthopaedic surgery in severe bleeding disorders: a low-volume, high-cost procedure
    V Mishra
    Health Professional Support Department, Rikshospitalet University Hospital, Oslo, Norway
    Haemophilia 8:809-14. 2002
    ..Activity-based financing, as used in Norway, does not provide a proper reimbursement for this part of the haemophilia care...
  77. ncbi Clinical and radiographic scores in haemophilic arthropathies: how well do these correlate to subjective pain status and daily activities?
    T Wallny
    Department of Orthopaedics, University of Bonn, Bonn, Germany
    Haemophilia 8:802-8. 2002
    ..Treatment of painful symptoms from arthropathies is often insufficient. Scores and questionnaires may help to define the haemophiliacs pain status more clearly, thereby offering a possibility of assessment and long-term observation...
  78. ncbi Blood-induced joint disease: the confluence of dysregulated oncogenes, inflammatory signals, and angiogenic cues
    Leonard A Valentino
    The RUSH Hemophilia and Thrombophilia Center, Department of Pediatrics, Rush Children s Hospital and Rush University Medical Center, Chicago, IL, USA
    Semin Hematol 45:S50-7. 2008
    ..Understanding these pathways and cataloguing their key components may identify new targets for therapy of HS...
  79. ncbi The overall effectiveness of prophylaxis in severe haemophilia
    J Panicker
    Department of Paediatrics and Paediatric Haematology Oncology, Children s Hospital of Michigan, Beaubien Boulevard, Detroit, MI, USA
    Haemophilia 9:272-8. 2003
    ..By preventing new target joints, prophylaxis can lead to reduction in long-term morbidity and a better quality of life despite increased central lines and higher factor usage...
  80. ncbi Prophylactic versus on-demand treatment strategies for severe haemophilia: a comparison of costs and long-term outcome
    K Fischer
    Department of Paediatrics, University Medical Center Utrecht, The Netherlands
    Haemophilia 8:745-52. 2002
    ..These findings suggest that, compared with a primarily on-demand treatment strategy, a primarily prophylactic treatment strategy leads to better outcome at equal treatment costs in young adults with severe haemophilia...
  81. ncbi Sonography for assessment of knee arthropathy in Brazilian haemophilic patients
    S V Antunes
    Haemophilia 14:145-6. 2008
  82. ncbi Total knee arthroplasty in hemophilic arthropathy
    Dhiren S Sheth
    Department of Orthopaedic Surgery, University of Texas Houston Health Science Center, 77030, USA
    J Arthroplasty 19:56-60. 2004
    ..Nine complications occurred in 6 knees. One patient died from HIV-related complications, and none of the patients seroconverted to HIV during the follow-up period...
  83. ncbi Radionuclide synovectomy and chronic haemophilic synovitis in Asians: a retrospective study
    E M D Chew
    Department of Orthopaedic Surgery, Singapore General Hospital, Singapore
    Haemophilia 9:632-7. 2003
    ..Radionuclide synovectomy appears to be effective in reducing the incidence of target joint haemarthrosis and quantity of factor usage for such bleeds among Asians with haemophilic synovitis...
  84. ncbi Feasibility of prophylaxis and immune tolerance induction regimens in haemophilic children using fully implantable central venous catheters
    Maria Elisa Mancuso
    Department of Medicine and Medical Specialities, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    Br J Haematol 141:689-95. 2008
    ..This study showed that ports improved the feasibility of prophylaxis in the majority of non-inhibitor children, while they were not suitable for inhibitor children who require a prolonged ITI regimen with daily infusions...
  85. ncbi A web-based registry of inherited bleeding disorders in the region of Emilia-Romagna: results at three and a half years
    A Tagliaferri
    Hub Emilia Romagna Haemophilia Centre, University Hospital, Parma, Italy
    Haemophilia 14:343-54. 2008
    ..The main features of registry are to collect high quality and comprehensive data of all patients followed by HC, to improve quality of care and it's availability on the web...
  86. ncbi Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe congenital haemophilia
    M Grunewald
    Department of Haematology, Haemostaseology Division, University of Ulm, Germany
    Haemophilia 8:768-75. 2002
    ..The association of a more intensely haemorrhagic phenotype with a paradoxical hyperstimulation of the fibrinolytic system resembles a vicious circle, where bleeding seems to cause predisposition to more bleeding...
  87. ncbi Prophylaxis for severe haemophilia: clinical and economical issues
    K Fischer
    Department of Paediatrics, University Medical Center Utrecht, The Netherlands
    Haemophilia 9:376-81. 2003
    ..In young adults, the cost of intermediate dose prophylaxis is similar, but outcome is better than for on demand treatment. The cost of high dose prophylaxis is twofold higher, further improving outcome only slightly...
  88. ncbi Correlation between clinical, radiological and ultrasonographical image of knee joints in children with haemophilia
    A Klukowska
    Departments of Paediatrics, Haematology and Oncology, Medical Academy, Warsaw, Poland
    Haemophilia 7:286-92. 2001
    ..Cartilage and bone damage progressed with the increase in the number of intra-articular haemorrhages into the knee joint. In our opinion USG is useful in evaluating the fluid, synovium and cartilage of joints in haemophiliacs...
  89. ncbi Experience of prophylaxis treatment in children with severe haemophilia
    T T Yee
    Haemophilia Centre and Haemostasis Unit, Royal Free NHS Trust, UK
    Haemophilia 8:76-82. 2002
    ..Parents' incentives for prophylaxis were that the children undertook many physical activities and sports previously not recommended, there was less parental anxiety and an overall improvement in the quality of life for the whole family...
  90. ncbi Some recent developments regarding arthropathy and inhibitors in haemophilia
    E C Rodriguez-Merchan
    Department of Orthopaedics and Haemophilia Unit, La Paz University Hospital, Madrid, Spain
    Haemophilia 14:242-7. 2008
    ....
  91. pmc Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function
    Vytautas Ivaskevicius
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, 53127 Bonn, Germany
    Haematologica 95:956-62. 2010
    ..deficiency is more common, but usually not associated with severe hemorrhage such as intracranial bleeding or hemarthrosis. In most cases, the disease is caused by F13A gene mutations...
  92. ncbi Magnetic resonance imaging in acute traumatic and chronic meniscal tears of the knee: a diagnostic accuracy study in young adults
    Paavo Ilari Kuikka
    Centre for Military Medicine, Research Unit, Helsinki, Finland
    Am J Sports Med 37:1003-8. 2009
    ..No previous research has investigated the diagnostic validity of magnetic resonance imaging for acute versus chronic meniscal tears using comparable materials and methods...
  93. ncbi Joint infection after knee arthroscopy: medicolegal aspects
    S Marmor
    Orthopaedic Department, Diaconesse Hospital Croix Saint Simon, 125, rue Avron, 75020 Paris, France
    Orthop Traumatol Surg Res 95:278-83. 2009
    ..This study analyzes the context of such infection occurrences, their management as well as their medicolegal consequences...
  94. pmc Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX
    Junjiang Sun
    Gene Therapy Center, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7220, USA
    Blood 112:4532-41. 2008
    ..Factor IX knockout (FIX(-/-)) mice received a puncture of the knee joint capsule with a needle to induce hemarthrosis; human factor IX (hFIX) was either injected through the needle into the joint space (intraarticularly) or ..
  95. ncbi Diagnosis of occult scaphoid fractures and other wrist injuries. Are repeated clinical examinations and plain radiographs still state of the art?
    C Gabler
    Department of Traumatology, University of Vienna Medical School, AKH Waehringer Guertel 18 20, 1090 Vienna, Austria
    Langenbecks Arch Surg 386:150-4. 2001
    ..complete or partial ruptures of the scapholunate ligament, ruptures of the radial collateral ligament, hemarthrosis)...
  96. ncbi A comparison of the spectrum of intra-articular lesions in acute and chronic anterior shoulder instability
    Christos K Yiannakopoulos
    Second Orthopaedic Department, Army General Hospital, Athens, Greece
    Arthroscopy 23:985-90. 2007
    ..The occurrence of glenoid shape alterations (inverted pear glenoid) in recurrent instability was especially examined...
  97. ncbi Severe musculoskeletal infection variant in Lemierre's syndrome
    Joshua D Harris
    Ohio State University Medical Center Department of Orthopedics, Division of Sports Medicine, Columbus, OH 43221 3502, USA joshua harris osumc edu
    Orthopedics 33:774. 2010
    ..Further unique findings in this case include the presence of a recent lateral meniscus tear with associated hemarthrosis treated with a short course of oral steroids prior to the diagnosis of septic arthritis...
  98. ncbi Glanzmann's thrombasthenia: an overview
    Meganathan Kannan
    Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
    Clin Appl Thromb Hemost 15:152-65. 2009
    ..GT include epistaxis, bruising, gingival hemorrhage, gastrointestinal hemorrhage, hematuria, menorrhagia, and hemarthrosis. Homozygous or compound heterozygous mutations in the genes of GPIIb and GPIIIa lead to GT...
  99. ncbi US of the shoulder: rotator cuff and non-rotator cuff disorders
    Athanasios Papatheodorou
    Department of Radiology, Hellenic Red Cross Hospital, 1 Athanasaki St, GR 115 26, Athens, Greece
    Radiographics 26:e23. 2006
    ..capsulitis and synovial osteochondromatosis; degenerative disorders such as osteoarthritis, amyloid arthropathy, hemarthrosis, and chondrocalcinosis; infectious disorders such as septic arthritis and bursitis; and space-occupying lesions.
  100. ncbi Clinical phenotypes and factor VII genotype in congenital factor VII deficiency
    Guglielmo Mariani
    Dipartimento di Medicina Interna e Sanita Pubblica, Università de L Aquila, Italy
    Thromb Haemost 93:481-7. 2005
    ..patients with a severe disease characterized by life-threatening and disabling symptoms (CNS, GI bleeding and hemarthrosis) strongly associated with an early age of presentation...
  101. ncbi Dental management of a patient with factor X deficiency
    Abi Adewumi
    Department of Pediatric Dentistry, Health Science Centre, P O Box 100426, University of Florida, Gainesville, FL 32610, USA
    J Can Dent Assoc 75:461-4. 2009
    ..may have severe posttraumatic or spontaneous internal or external bleeding, leading to such complications as hemarthrosis or hemorrhagic strokes...

Research Grants5

  1. FATE OF THE ANTERIOR CRUCIATE INJURED KNEE
    DALE DANIEL; Fiscal Year: 1990
    ..included in the study presented with their first knee injury within fourteen days of the injury event, had a hemarthrosis and were suspected of being an ACL injury...
  2. FONDAPARINUM IN CHILDREN WITH THROMBOSIS
    Guy Young; Fiscal Year: 2007
    ..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. [unreadable] [unreadable]..
  3. Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in children
    Guy Young; Fiscal Year: 2009
    ..More modern therapies are available but have not been systematically tested in children. This study will determine whether one such medication, bivalirudin is a safer and more effective alterative. ..
  4. ANNEXIN II & PLASMIN MEDIATED HIGH GRADE GLIOMA INVASION
    Suchitra Acharya; Fiscal Year: 2002
    ..Dr. Hajjar is also very accessible for individual weekly meetings when the need arises. T h i s environment will provide excellent training for a developing physician-researcher. ..
  5. Role of Carboxyterminal Hypervariable Region in Rap1b Function
    Gilbert C White; Fiscal Year: 2010
    ..These findings will provide insight into how the body heals bleeding injuries, as well as the underlying cause of blood clotting conditions. ..