arthritis

Summary

Top Publications

  1. ncbi A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
    G A Taylor
    Howard Hughes Medical Institute Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 4:445-54. 1996
  2. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
  3. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
  4. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
  5. pmc Chikungunya virus arthritis in adult wild-type mice
    Joy Gardner
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health, Brisbane, Australia
    J Virol 84:8021-32. 2010
  6. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
  7. pmc Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice
    Andres Gomez
    Institute for Genomic Biology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 7:e36095. 2012
  8. pmc Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk
    Siddaraju M Nanjundaiah
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:22216-26. 2012
  9. pmc A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis
    Danher Wang
    Division of Biodefense Vaccines, GenPhar, Inc, Mount Pleasant, SC 29464, USA
    Vaccine 29:2803-9. 2011
  10. ncbi Clinical and pathologic aspects of arthritis due to Ross River virus and other alphaviruses
    Andreas Suhrbier
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health and Nutrition, Brisbane, Australia
    Curr Opin Rheumatol 16:374-9. 2004

Detail Information

Publications309 found, 100 shown here

  1. ncbi A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
    G A Taylor
    Howard Hughes Medical Institute Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 4:445-54. 1996
    ..but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cachexia, erosive arthritis, dermatitis, conjunctivitis, glomerular mesangial thickening, and high titers of anti-DNA and antinuclear ..
  2. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
    ..that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals...
  3. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..We investigated the role of platelets in the autoimmune disease rheumatoid arthritis. We identified platelet microparticles--submicrometer vesicles elaborated by activated platelets--in joint fluid ..
  4. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
    ..collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease...
  5. pmc Chikungunya virus arthritis in adult wild-type mice
    Joy Gardner
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health, Brisbane, Australia
    J Virol 84:8021-32. 2010
    ..Here we describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans...
  6. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..Development of two specific pathologies in mutant mice, i.e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for ..
  7. pmc Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice
    Andres Gomez
    Institute for Genomic Biology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 7:e36095. 2012
    ..is associated with susceptibility, while HLA-DRB1 0402 is associated with resistance to developing rheumatoid arthritis (RA) and collagen-induced arthritis in humans and transgenic mice respectively...
  8. pmc Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk
    Siddaraju M Nanjundaiah
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:22216-26. 2012
    Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints...
  9. pmc A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis
    Danher Wang
    Division of Biodefense Vaccines, GenPhar, Inc, Mount Pleasant, SC 29464, USA
    Vaccine 29:2803-9. 2011
    ..Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available...
  10. ncbi Clinical and pathologic aspects of arthritis due to Ross River virus and other alphaviruses
    Andreas Suhrbier
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health and Nutrition, Brisbane, Australia
    Curr Opin Rheumatol 16:374-9. 2004
    ..This article summarizes the current knowledge of these diseases, focusing on recent developments in the understanding of Ross River virus disease...
  11. pmc Complement drives Th17 cell differentiation and triggers autoimmune arthritis
    Motomu Hashimoto
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 207:1135-43. 2010
    ..of mannan or beta-glucan, both of which activate serum complement, evoked Th17 cell-mediated chronic autoimmune arthritis. C5a, a chief component of complement activation produced via all three complement pathways (i.e...
  12. pmc An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
    JAIME DARCE
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:731-41. 2012
    ..GFP-FoxP3 mice showed a divergent susceptibility to autoimmune disease: protection against antibody-mediated arthritis in the K/BxN model, but greater susceptibility to diabetes on the NOD background...
  13. ncbi T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    H Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Nature 408:600-5. 2000
    ..family that is essential for osteoclastogenesis, may contribute to pathological conditions, such as autoimmune arthritis. However, whether activated T cells maintain bone homeostasis by counterbalancing the action of RANKL remains ..
  14. pmc EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    B Combe
    Immuno Rhumatologie, Lapeyronie Hosp, Montpellier, France
    Ann Rheum Dis 66:34-45. 2007
    To formulate EULAR recommendations for the management of early arthritis.
  15. pmc Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
    Omar M Khan
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
    J Clin Invest 121:628-39. 2011
    ..show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis. The disease was initiated by the GGTase-I-deficient macrophages and was transplantable and reversible in bone ..
  16. pmc Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis
    Mark J Harrison
    The arc Epidemiology Unit, The University of Manchester, Manchester, M13 9PT, UK
    Health Qual Life Outcomes 8:21. 2010
    ..aim of this study was to evaluate a published method of estimating the EuroQol-5D (EQ-5D) and Short Form-6D (SF-6D) (preference based) utility scores from the Health Assessment Questionnaire (HAQ) in patients with inflammatory arthritis.
  17. pmc The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats
    J F Lima-Garcia
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Br J Pharmacol 164:278-93. 2011
    ..Here, we have investigated the possible anti-hyperalgesic effects of two lipids, aspirin-triggered resolvin D1 (AT-RvD1) and its precursor, 17(R)-hydroxy-4Z,7Z,10Z,13Z,15E,17R,19Z-docosahexaenoic acid (17(R)HDoHE)...
  18. ncbi NOD2 gene-associated pediatric granulomatous arthritis: clinical diversity, novel and recurrent mutations, and evidence of clinical improvement with interleukin-1 blockade in a Spanish cohort
    Juan I Arostegui
    Servicio de Inmunologia, Hospital Clinic, Barcelona, Spain
    Arthritis Rheum 56:3805-13. 2007
    ..early-onset sarcoidosis are NOD2 gene-associated chronic autoinflammatory diseases characterized by skin rash, arthritis, and/or eye involvement, with noncaseating granulomata as their pathologic hallmark...
  19. ncbi Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern
    I Dahlman
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Eur J Immunol 28:2188-96. 1998
    ..We have investigated whether five non-MHC QTL controlling susceptibility to experimental arthritis in the DA rat also influence myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune ..
  20. pmc Interleukin 6 is required for the development of collagen-induced arthritis
    T Alonzi
    Istituto Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
    J Exp Med 187:461-8. 1998
    Interleukin-6 (IL-6) is overproduced in the joints of patients with rheumatoid arthritis (RA) and, based on its multiple stimulatory effects on cells of the immune system and on vascular endothelia, osteoclasts, and synovial fibroblasts, ..
  21. ncbi A mini-review: microRNA in arthritis
    Tomoyuki Nakasa
    Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Physiol Genomics 43:566-70. 2011
    ..MiRNAs play an important role in human diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA)...
  22. ncbi Role of the mouse ank gene in control of tissue calcification and arthritis
    A M Ho
    Department of Developmental Biology and Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305 5327, USA
    Science 289:265-70. 2000
    Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction...
  23. pmc Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial)
    P Emery
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds corrected
    Ann Rheum Dis 69:510-6. 2010
    Several agents provide treatment for established rheumatoid arthritis (RA), but a crucial therapeutic goal is to delay/prevent progression of undifferentiated arthritis (UA) or very early RA.
  24. ncbi Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity and radiographic outcome
    Lene S Knudsen
    Department of Rheumatology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    J Rheumatol 35:1277-87. 2008
    ..6 (pIL-6), plasma vascular endothelial growth factor (pVEGF), and serum (s) YKL-40 in patients with early rheumatoid arthritis (RA) and unclassified polyarthritis (PA), and investigate their relationship with radiographic outcome.
  25. pmc IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis
    Carine Bouffi
    INSERM, Unité 844, Montpellier, France
    PLoS ONE 5:e14247. 2010
    ..mechanisms underlying the suppressive effect of MSCs in vivo, using cells isolated from mice deficient in the production of inducible nitric oxide synthase (iNOS) or interleukin (IL)-6 in the murine model of collagen-induced arthritis.
  26. ncbi Mechanical loading, cartilage degradation, and arthritis
    Hui B Sun
    Leni and Peter W May Department of Orthopedics, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1211:37-50. 2010
    ..The irreversible destruction of cartilage is the hallmark of osteoarthritis and rheumatoid arthritis. In these instances of cartilage breakdown, inflammatory cytokines such as interleukin-1 beta and tumor necrosis ..
  27. ncbi Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis
    Paul J Egan
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Arthritis Rheum 58:3720-9. 2008
    To examine the generation of proinflammatory Th17 cells at the site of tissue inflammation and in draining lymph nodes using an interleukin-17 (IL-17)-dependent model of acute inflammatory arthritis.
  28. ncbi Natural products as a gold mine for arthritis treatment
    Dinesh Khanna
    Division of Immunology, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Curr Opin Pharmacol 7:344-51. 2007
    b>Arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g...
  29. ncbi Intraindividual variability in cognitive performance in older adults: comparison of adults with mild dementia, adults with arthritis, and healthy adults
    D F Hultsch
    Department of Psychology, University of Victoria, British Columbia, Canada
    Neuropsychology 14:588-98. 2000
    ..across both trials and occasions was examined in 3 groups of older adults: healthy adults, adults with arthritis, and adults diagnosed with mild dementia...
  30. ncbi The role of ADAMTSs in arthritis
    Edward A Lin
    Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 10003, USA
    Protein Cell 1:33-47. 2010
    ..and mutation of these enzymes have been implicated in many disease processes, such as inflammation, cancer, arthritis and atherosclerosis...
  31. ncbi Contemporary concepts of inflammation, damage and repair in rheumatic diseases
    Frank P Luyten
    University Hospitals Leuven, Division of Rheumatology, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Rheumatol 20:829-48. 2006
    Chronic arthritis has been regarded as a disease resulting from a disequilibrium in pro- and anti-inflammatory cytokines...
  32. ncbi Construct validity of a multidimensional electronic pain diary for adolescents with arthritis
    Jennifer N Stinson
    Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ont, Canada
    Pain 136:281-92. 2008
    ..and feasibility of a multidimensional electronic pain diary (e-Ouch(c)) in adolescents with juvenile idiopathic arthritis (JIA). Two descriptive studies with repeated measures were conducted between January and December 2005...
  33. ncbi Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
    Noriko Komatsu
    1 Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan 2 Japan Science and Technology Agency JST, Exploratory Research for Advanced Technology ERATO Program, Takayanagi Osteonetwork Project, Bunkyo ku, Tokyo, Japan
    Nat Med 20:62-8. 2014
    ..Here we show that TH17 cells originating from Foxp3(+) T cells have a key role in the pathogenesis of autoimmune arthritis. Under arthritic conditions, CD25(lo)Foxp3(+)CD4(+) T cells lose Foxp3 expression (herein called exFoxp3 cells) ..
  34. pmc Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis
    Martijn J C van Herwijnen
    Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 109:14134-9. 2012
    ..II and that upon transfer, B29-induced CD4(+)CD25(+)Foxp3(+) T cells suppress established proteoglycan-induced arthritis in mice...
  35. ncbi Empowering processes and outcomes of participation in online support groups for patients with breast cancer, arthritis, or fibromyalgia
    Cornelia F van Uden-Kraan
    Institute for Behavioral Research, Faculty of Behavioral Sciences, University of Twente, Enschede, The Netherlands
    Qual Health Res 18:405-17. 2008
    ..This article demonstrates that participation in online support groups can make a valuable contribution to the emergence of empowered patients...
  36. ncbi An 8-yr follow-up of arthritis self-management programme participants
    J Barlow
    Self Management Programme, Applied Research Centre in Health and Lifestyle Interventions, Faculty of Health and Life Sciences, Coventry University, Whitefriars Building, Priory Street, Coventry CV15FB, UK
    Rheumatology (Oxford) 48:128-33. 2009
    ..the pattern of scores on self-efficacy, health status and use of self-management techniques among a group of Arthritis Self-Management Programme (ASMP) participants over an 8-yr period, and to describe participants' perspectives of ..
  37. pmc Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois
    J Clin Invest 94:1012-8. 1994
    We and others have shown that cells obtained from inflamed joints of rheumatoid arthritis (RA) patients produce interleukin-8, a potent chemotactic cytokine for neutrophils (PMNs)...
  38. pmc Total hip arthroplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial
    Matthew L Costa
    Warwick Clinical Trials Unit, Division of Health Sciences, University of Warwick, Coventry CV4 7AL, UK
    BMJ 344:e2147. 2012
    To compare the clinical and cost effectiveness of total hip arthroplasty with resurfacing arthroplasty in patients with severe arthritis of the hip.
  39. ncbi S100 Calgranulins in inflammatory arthritis
    Chandima Perera
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Immunol Cell Biol 88:41-9. 2010
    ..S100 calcium-binding proteins are important molecular mediators in a range of diseases, including inflammatory arthritis, atherosclerosis and microbial infections...
  40. ncbi EULAR recommendations for the role of the nurse in the management of chronic inflammatory arthritis
    Yvonne van Eijk-Hustings
    Department of Integrated Care, Maastricht University Medical Centre, Postbox 5800, 6202 AZ Maastricht, The Netherlands
    Ann Rheum Dis 71:13-9. 2012
    ..authors aim to develop European League Against Rheumatism recommendations for the role of the nurse in the management of patients with chronic inflammatory arthritis, to identify a research agenda and to determine an educational agenda.
  41. ncbi Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis
    Carol M Aherne
    College of Life Sciences, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Immunol 46:3345-57. 2009
    ..the chemoattractant protein, interleukin 8 (IL-8/CXCL8), as a molecular target of NR4A2 in human inflammatory arthritis and examines the mechanism through which NR4A2 modulates IL-8 expression...
  42. pmc Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis
    K Bendtzen
    Rigshospitalet National University Hospital, Copenhagen, Denmark
    Clin Exp Immunol 134:151-8. 2003
    ..to evaluate the safety and efficacy of spironolactone as an anti-inflammatory drug 21 patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) or other arthritides were treated for up to 22 months with 1-3 mg/kg/..
  43. ncbi Arthritis-related work transitions: a prospective analysis of reported productivity losses, work changes, and leaving the labor force
    Monique A M Gignac
    Arthritis Community Research and Evaluation Unit and University of Toronto, Ontario, Canada
    Arthritis Rheum 59:1805-13. 2008
    To prospectively examine arthritis-related productivity losses, work changes, and leaving employment, the relationships among these work transitions, and the factors associated with them.
  44. pmc JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis
    Monica Guma
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:22122-7. 2010
    Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by bone and cartilage destruction...
  45. ncbi Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Pécsi u 6, Hungary
    Eur J Pharmacol 622:58-64. 2009
    ..PC) and non-steroidal diclofenac supplementation on polymorphonuclear cell influx in carrageenan-induced arthritis in rats...
  46. ncbi Suppressing effect of low-dose gamma-ray irradiation on collagen-induced arthritis
    Hiroko Nakatsukasa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba, Japan
    J Radiat Res 49:381-9. 2008
    ..Here, we studied the effect of low-dose gamma-ray irradiation on collagen-induced arthritis (CIA) in DBA/1J mice. Mice were immunized with type II collagen, and exposed to low-dose gamma-rays (0...
  47. pmc Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
    Dallas Jones
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2534-42. 2011
    ..and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.
  48. pmc Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
    J J Haringman
    Division of Clinical Immunology and Rheumatology F4 218, Department of Internal Medicine, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 65:294-300. 2006
    ..Chemokine receptors and chemokines have a crucial role in leucocyte recruitment into inflamed tissue...
  49. pmc Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]
    Rashmi Singh
    Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, India
    Life Sci 86:907-18. 2010
    ..have been shown to inhibit the inflammatory responses in vitro in different cell types and the development of arthritis in animal model studies...
  50. pmc Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
    Shin ichiro Sawa
    Laboratory of Developmental Immunology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Exp Med 203:1459-70. 2006
    ..and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease...
  51. ncbi Progress in assessing physical function in arthritis: PROMIS short forms and computerized adaptive testing
    James F Fries
    Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Rheumatol 36:2061-6. 2009
    ..with the Health Assessment Questionnaire Disability Index (HAQ) and other instruments has become central in arthritis research...
  52. ncbi Payback arising from research funding: evaluation of the Arthritis Research Campaign
    S Wooding
    RAND Europe, Grafton House, Cambridge, UK
    Rheumatology (Oxford) 44:1145-56. 2005
    ..evaluation framework to systematically review and document the outputs and outcomes of research funded by the Arthritis Research Campaign in the early 1990s...
  53. pmc Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    Richard C Chou
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 33:266-78. 2010
    ..B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitment into the joint in autoantibody-induced arthritis. We now demonstrate that BLT1 is required for neutrophils to deliver IL-1 into the joint to initiate arthritis...
  54. ncbi Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 50:817-27. 2004
    To evaluate synovial fluid (SF) for the presence of mesenchymal progenitor cells (MPCs), to compare SF MPCs with bone marrow (BM) MPCs, and to enumerate these cells in both inflammatory arthritis and osteoarthritis (OA).
  55. ncbi The costs of arthritis
    Dorothy D Dunlop
    Feinberg School of Medicine, Chicago, Illinois, USA
    Arthritis Rheum 49:101-13. 2003
  56. ncbi Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity
    L Zhang
    Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 89:265-73. 2001
    ..These results indicate that endogenous CGRP plays an important role in the plastic neurogenic changes occurring in response to peripheral inflammatory events including the development of nociceptive behaviors...
  57. ncbi Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
    M Mihara
    Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan
    Clin Immunol 98:319-26. 2001
    ..MRA can react with monkey IL-6R and block signal transduction of IL-6. Collagen-induced arthritis (CIA) was induced by twice immunizing with bovine type II collagen (CII) emulsified with complete adjuvant...
  58. ncbi MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
    K Holmbeck
    MMP Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    Cell 99:81-92. 1999
    ..MT1-MMP deficiency causes craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues due to ablation of a collagenolytic activity that is ..
  59. ncbi Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-making
    Annette H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:2241-7. 2008
    The decision to start disease-modifying antirheumatic drugs in patients with recent-onset undifferentiated arthritis (UA) is complicated by a varied natural disease course in which the disease in one-third of patients progresses to ..
  60. pmc Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 65:366-71. 2006
    To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis.
  61. ncbi Osteoclastogenesis and arthritis
    Nicola Maruotti
    Department of Rheumatology, University of Foggia Medical School, Italy
    Clin Exp Med 11:137-45. 2011
    ..for osteoclasts as key players in the erosive and inflammatory events leading to joint destruction in chronic arthritis. In fact, chronic inflammatory joint diseases such as psoriatic arthritis and rheumatoid arthritis are often ..
  62. ncbi Physical activity in men and women with arthritis National Health Interview Survey, 2002
    Margaret Shih
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Health Services, CA 90012, USA
    Am J Prev Med 30:385-93. 2006
    Regular physical activity in persons with arthritis has been shown to decrease pain, improve function, and delay disability...
  63. ncbi e-Ouch: usability testing of an electronic chronic pain diary for adolescents with arthritis
    Jennifer N Stinson
    Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    Clin J Pain 22:295-305. 2006
    The aim of this study was to evaluate the usability of the e-Ouch electronic chronic pain diary in adolescents with juvenile idiopathic arthritis.
  64. pmc Yoga for arthritis: a scoping review
    Steffany Haaz
    Department of Health, Behavior and Society, Johns Hopkins School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Rheum Dis Clin North Am 37:33-46. 2011
    This article reviews the existing literature on using yoga for arthritis. It includes peer-reviewed research from clinical trials (published from 1980 to 2010) that used yoga as an intervention for arthritis and reported quantitative ..
  65. ncbi Musculoskeletal pain in the workforce: the effects of back, arthritis, and fibromyalgia pain on quality of life and work productivity
    Margaret McDonald
    Pfizer Inc, New York, NY, USA
    J Occup Environ Med 53:765-70. 2011
    ..To investigate the impact of musculoskeletal pain on health-related quality of life and work productivity losses among US workers...
  66. ncbi STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    Mi La Cho
    The Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, 505 Banpo Dong, Seocho Ku, 137 040 Seoul, Korea
    J Immunol 176:5652-61. 2006
    ..of IL-23 in CD4(+) T cells in mice lacking the IL-1R antagonist (IL-1Ra(-/-)), an animal model of spontaneous arthritis. IL-23 was strongly expressed in the inflamed joints of IL-1Ra(-/-) mice...
  67. ncbi Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus
    Brett A Lidbury
    Virus and Inflammation Research Group, Faculty of Sciences, University of Canberra, Australia
    J Infect Dis 197:1585-93. 2008
    ..To our knowledge, these findings are the first to demonstrate that macrophage-derived products play important roles in the development of arthritis and myositis triggered by alphavirus infection.
  68. pmc Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    Tracey M Farragher
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:359-69. 2008
    To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA).
  69. ncbi Platelets: active players in the pathogenesis of arthritis and SLE
    Eric Boilard
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, faculté de médecine de l université Laval, Quebec, Room T1 49, 2705 Laurier Boulevard, QC G1V 4G2, Canada eric boilard crchuq ulaval ca
    Nat Rev Rheumatol 8:534-42. 2012
    ..Studies have shown that platelets can have unexpected roles in rheumatic diseases. In patients with rheumatoid arthritis (RA), IL-1-containing platelet-derived vesicles called microparticles are abundant in arthritic joint fluid...
  70. ncbi High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients
    M C Honorati
    Laboratorio Immunologia e Genetica, Istituto Codivilla Putti IOR, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Rheumatology (Oxford) 40:522-7. 2001
    ..To evaluate the presence of interleukin-17 (IL-17) and the expression of IL-17 receptor (IL-17R) in joint tissues from subjects with different arthritides...
  71. ncbi Progression to rheumatoid arthritis in early inflammatory arthritis is associated with low IL-7 serum levels
    Vincent Goeb
    Division of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
    Ann Rheum Dis 72:1032-6. 2013
    Early diagnosis of rheumatoid arthritis (RA) remains a challenge. Interleukin (IL)-7 is a pleiotropic cytokine that plays a central role in the development and maintenance of T-cells and has been associated with T-cell dysfunction in RA...
  72. ncbi Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Gastroenterology 127:1038-43. 2004
    The gastric safety of cyclooxgenase-2 inhibitors and prophylactic antisecretory therapy in high-risk arthritis patients is unclear...
  73. ncbi Health of children with chronic arthritis: relationship of different measures and the quality of parent proxy reporting
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Arthritis Rheum 51:763-73. 2004
    ..measures of health-related quality of life (HRQOL), disability, pain, and well-being in children with chronic arthritis. To evaluate whether HRQOL scores vary as a function of disability status beyond chance...
  74. ncbi Persistent diarrhea, arthritis, and other complications of enteric infections: a pilot survey based on California FoodNet surveillance, 1998-1999
    Judy R Rees
    California Emerging Infections Program, Oakland, CA, USA
    Clin Infect Dis 38:S311-7. 2004
    Numerous complications of enteric infections have been described, including persistent diarrhea, reactive arthritis, and Guillain-Barre syndrome...
  75. ncbi Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy
    Shengnan Xiang
    The Key Laboratory of Stem Cell Biology, Shanghai Jiao Tong University School of Medicine SJTUSM and Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS, Shanghai, PR China
    Biomaterials 33:6520-32. 2012
    ..cytokine interleukin-1 receptor antagonist (IL-1Ra) gene to rat synoviocytes, an optimal target for arthritis treatment...
  76. pmc An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis
    Elizabeth J Sutton
    Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Opt Express 17:24403-13. 2009
    ..The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints...
  77. ncbi Joint expedition: linking gut inflammation to arthritis
    P Jacques
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Mucosal Immunol 1:364-71. 2008
    The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively...
  78. ncbi Control of arthritis pain with anti-nerve-growth factor: risk and benefit
    Matthias F Seidel
    Section of Rheumatology, Medizinische Klinik und Poliklinik III, University Hospital, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Curr Rheumatol Rep 14:583-8. 2012
    b>Arthritis is characterized by pain and inflammation...
  79. ncbi Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus
    Filipa Pinto-Ribeiro
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Brain Res 1197:63-75. 2008
    We studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat...
  80. pmc Interleukin 15 levels in serum may predict a severe disease course in patients with early arthritis
    Isidoro Gonzalez-Alvaro
    Rheumatology Service, Hospital Universitario de la Princesa, IIS Princesa, Madrid, Spain
    PLoS ONE 6:e29492. 2011
    ..Therefore, the objective of this work is to analyse whether serum IL-15 (sIL-15) levels serve as a biomarker of disease severity in patients with early arthritis (EA).
  81. pmc Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?
    Bridget Fox
    Peninsula Medical School, University of Exeter, St Luke s Campus, Exeter, Devon, UK
    J Cell Mol Med 16:896-910. 2012
    ..These data suggest CSE is an inducible source of H(2)S in cultured HACs and MPCs. H(2)S may represent a novel endogenous mechanism of cytoprotection in the inflamed joint, suggesting a potential opportunity for therapeutic intervention...
  82. ncbi Worker productivity loss associated with arthritis
    Wayne N Burton
    Department of Environmental and Occupational Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Dis Manag 9:131-43. 2006
    This study at a major financial services corporation sought to investigate the association of arthritis with on-the-job productivity, also termed "presenteeism...
  83. ncbi Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis
    W P Cheevers
    Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Virology 306:116-25. 2003
    This study evaluated the efficacy of prime-boost vaccination for immune control of caprine arthritis-encephalitis virus (CAEV), a macrophage tropic lentivirus that causes progressive arthritis in the natural host...
  84. ncbi Antioxidant and anti-inflammatory effect of polysaccharides from Lobophora variegata on zymosan-induced arthritis in rats
    Almino Afonso de O Paiva
    Department of Biochemistry, Universidade Federal do Rio Grande do Norte UFRN, Natal, RN, Brazil
    Int Immunopharmacol 11:1241-50. 2011
    ..study analyzes the action of sulfated polysaccharides, fucans, from algae Lobophora variegata on zymosan-induced arthritis in rats. Groups of fucans, obtained after acetone fractionation (0.3-2.0 volumes), were denominated F0.3, F0...
  85. ncbi A loss of function mutation in the COL9A2 gene causes autosomal recessive Stickler syndrome
    Stuart Baker
    Connective Tissue Gene Tests, Allentown, Pennsylvania 18106, USA
    Am J Med Genet A 155:1668-72. 2011
    ..Together the data from the present study and the previous studies suggest that loss-of-function mutations in any of the collagen IX genes can cause autosomal recessive Stickler syndrome...
  86. ncbi Interactions between gut inflammation and arthritis/spondylitis
    Peggy Jacques
    Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium
    Curr Opin Rheumatol 22:368-74. 2010
    ..The spectrum of spondyloarthritis is characterized by the intriguing co-occurrence of gut and joint inflammation, although no obvious anatomical link exists...
  87. pmc Factors that influence exercise among adults with arthritis in three activity levels
    Cheryl Der Ananian
    Institute for Health Research and Policy, University of Illinois at Chicago, M C 275, 1747 W Roosevelt Rd, Room 558, Chicago, IL 60608, USA
    Prev Chronic Dis 3:A81. 2006
    Recent public health objectives emphasize the importance of exercise for reducing disability among people with arthritis. Despite the documented benefits of exercise, people with arthritis are less active than those without arthritis...
  88. ncbi Chronic disease and labour force participation among older Australians
    Deborah J Schofield
    Northern Rivers University Department of Rural Health, Lismore, NSW, Australia
    Med J Aust 189:447-50. 2008
    ..To examine the association between long-term health conditions and being out of the labour force among older Australians...
  89. ncbi The role of properdin in murine zymosan-induced arthritis
    Petya Dimitrova
    Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Mol Immunol 47:1458-66. 2010
    ..and wild-type mice, we have investigated the role of properdin in development and progression of zymosan-induced arthritis. At the initial phase of local, zymosan-induced inflammation, properdin-deficient and wild-type mice showed bone ..
  90. ncbi Health care utilization for musculoskeletal disorders
    Crystal MacKay
    Arthritis Community Research and Evaluation Unit, Toronto Western Research Institute, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 62:161-9. 2010
    To examine patterns of ambulatory care and hospital utilization for people with musculoskeletal disorders (MSDs), including arthritis and related conditions, bone and spinal conditions, trauma and related conditions, and unspecified MSDs.
  91. ncbi Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis
    Matthew C Becker
    Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
    Am Heart J 157:606-12. 2009
    Pain management in patients with osteoarthritis or rheumatoid arthritis often requires long-term use of nonsteroidal antiinflammatory drugs (NSAIDs). However, the relative cardiovascular safety of these therapies remains uncertain.
  92. ncbi Protocol for the induction of arthritis in C57BL/6 mice
    Julia J Inglis
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Nat Protoc 3:612-8. 2008
    Collagen-induced arthritis is a well-validated, but strain-dependent mouse model of rheumatoid arthritis, with H-2(q) and H-2(r) strains showing the greatest degree of susceptibility...
  93. ncbi Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex
    Jian Ping Guo
    Center for Molecular Medicine, Stockholm, Sweden
    Arthritis Rheum 58:1343-53. 2008
    The antigen-presenting lectin-like receptor complex (APLEC) was recently identified as a genetic determinant for arthritis susceptibility...
  94. ncbi The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis
    Yu Tsan Lin
    Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Autoimmun Rev 10:482-9. 2011
    Juvenile idiopathic arthritis (JIA) has had a long and difficult problem with classification. It is clearly a heterogeneous and multi-factorial autoimmune disease but all too often the distinctions among subtypes were unclear...
  95. ncbi Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis
    Feng Lai Yuan
    The Third Hospital Affiliated to Nantong University, 214041, Wuxi, Jiangsu, People s Republic of China
    Mol Biol Rep 37:3233-8. 2010
    ..that ASIC3 have important biological effects in inflammation that might be a promising therapeutic target for arthritis pain...
  96. ncbi Community-based physical activity intervention
    Patricia A Sharpe
    Prevention Research Center, Norman J Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Arthritis Rheum 49:455-62. 2003
  97. ncbi Arthroscopic glenoid resurfacing as a surgical treatment for glenohumeral arthritis in the young patient: midterm results
    Felix H Savoie
    Department of Orthopaedic Surgery, Tulane University, New Orleans, LA70112, USA
    Arthroscopy 25:864-71. 2009
    ..This study investigates the hypothesis that arthroscopic biologic glenoid resurfacing without humeral head replacement will provide results similar to humeral hemiarthroplasty in patients aged under 60 years...
  98. ncbi Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?
    Diederik P C de Rooy
    Department of Rheumatology, Leiden University Medical Center, C1 46, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Rheumatology (Oxford) 50:93-100. 2011
    ..In early undifferentiated arthritis (UA), prediction of the development of RA is crucial, and in case of RA predicting the severity of the disease ..
  99. ncbi The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis
    Klaus P Machold
    Medical University of Vienna, Vienna A 1090, Austria
    Ann Rheum Dis 69:495-502. 2010
    Glucocorticoids (GCs) are often used as early arthritis treatment and it has been suggested that they induce remission or at least delay the development of rheumatoid arthritis (RA) and the need to start disease-modifying antirheumatic ..
  100. ncbi An internet-based self-management program with telephone support for adolescents with arthritis: a pilot randomized controlled trial
    Jennifer N Stinson
    Child Health Evaluative Sciences, Chronic Pain Program, Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Rheumatol 37:1944-52. 2010
    ..self-management strategies, and social support with telephone support for youth with juvenile idiopathic arthritis (JIA) and their parents, aimed at reducing physical and emotional symptoms and improving health-related quality ..
  101. pmc The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
    Jennifer M McCoy
    Pfizer Global Research and Development, Department of Inflammation and Pathology, Groton, Connecticut 06340, USA
    J Clin Invest 110:651-8. 2002
    Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to bone and cartilage destruction...

Research Grants74

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..It is associated with immune system disorders like rheumatoid arthritis. It can cause blindness in severe cases...
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..anti-inflammatory actions in atherosclerosis (Fig/s 2 &3), transplant vasculopathy, and collagen-induced arthritis in animal models...
  5. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..substantially increases the risk of systemic illness such as cardiovascular and renal disease, rheumatoid arthritis, and pregnancy complications...
  6. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..using an anti-CD20 antibody that mimics the agent Rituximab, now used in humans to treat refractory Rheumatoid Arthritis and certain B cell lymphomas...
  7. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ..AS in which spine involvement is associated with sacroiliitis, uveitis and frequently but not always peripheral arthritis. Using genome-wide screening, we identified Pgis2 (on chromosome [Chr] 2, syntenic with human Chr9:SPA locus) as ..
  8. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..role of nerve growth factor (NGF) and its receptor system (NGF-R) in the pathogenesis of psoriasis and psoriatic arthritis (PsA)...
  9. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..elevated levels of OPN-R and its CPB-cleaved product, OPN-Leu (OPN-L), in synovial fluid samples from rheumatoid arthritis patients and these cleaved OPN forms affect neutrophils and fibroblast-like synoviocytes...
  10. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..peliosis hepatis, granulomatous inflammatory disease, and, most recently, neurological dysfunction and arthritis. Traditional methods for detecting bacterial infections in patient samples have proven to be largely ineffective ..
  11. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..It is a serious complication of many chronic inflammatory diseases including rheumatoid arthritis, ankylosing spondylitis, regional enteritis (Crohn's disease), and inherited recurrent febrile diseases ..
  12. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..B cells are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. To function effectively, B cells need to migrate in the lymphoid tissues for surveillance, and upon binding ..
  13. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..of CTLA-4 that reduces N-glycan number by ~50%, increasing the risk of Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) by ~2 fold...
  14. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    PROJECT SUMMARY\ABSTRACT Predisposition to develop Rheumatoid arthritis (RA) is associated with the presence of certain HLA alleles while others offer resistance...
  15. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..and Specific Challenge Topic: 01-AR-101 "Integrating Behavioral and Biomedical Research Approaches in Arthritis and Musculoskeletal Diseases" Patients with rheumatoid arthritis (RA), other chronic arthritides and other ..
  16. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..Multiple sclerosis, rheumatoid arthritis, pediatric arthritis, insulin-dependent diabetes, idiopathic thrombocytopenia and pediatric lupus are other key ..
  17. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..shown to be a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  18. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..Inflammation is at the root of many chronic diseases, including coronary heart disease, diabetes, arthritis, obesity, macular degeneration, dry eye, osteoporosis, Alzheimer's disease and mental health disorders, and ..
  19. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Widespread bone disorders including osteoporosis, arthritis, periodontal bone disease, joint replacement loosening, and tumor metastasis to bone, all have in common bone ..
  20. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..disease, Parkinson's disease, multiple sclerosis, inflammatory bowel disease, kidney disease, rheumatoid arthritis and chronic obstructive pulmonary disease, where aberrant MPO activity has been implicated...
  21. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..of enhanced susceptibility to diverse syndromes including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Type I diabetes (T1D)...
  22. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..decreased serum levels of 25(OH)VD3 have been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and multiple sclerosis (MS)...
  23. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..AA amyloidosis is associated mostly with chronic inflammatory disorders and includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowl disease, tuberculosis, leprosy, Hodgkin's disease,..
  24. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..This murine model (PG-induced arthritis;PGIA) shares similarities with rheumatoid arthritis (RA) as indicated by clinical assessments, laboratory tests, ..
  25. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..research projects encompass three different autoimmune diseases [diffuse systemic sclerosis (SSc), psoriatic arthritis and systemic juvenile idiopathic arthritis (SJIA)] that afflict adults and children, as well as organ systems ..
  26. OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITIS
    Cornelia M Weyand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a quintessential autoimmune syndrome with tissue-destructive chronic inflammatory lesions attacking the synovium and a wide spectrum of extra-articular organs...
  27. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Anti-IL-12p40 antibodies (Ustekinumab) which suppress Th17 cytokine elaboration have recently been approved for ..
  28. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Description: In rheumatoid arthritis (RA), an inflammatory stimulus from secreted cytokines increases osteoclast activity, erodes bone surfaces, and progressively destroys joints...
  29. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..that these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing significant adverse effects. Aim.1...
  30. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..ER suppression of NFB is critical for protective effects of estrogens in inflammatory bowel disease, sepsis, arthritis, atherosclerosis, and lipid metabolism, highlighting the broad importance of this pathway...
  31. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..prostatitis, epididymitis, urosepsis, septicemia, orchitis, endocarditis, vertebral osteomyelitis, septic arthritis, endophthalmitis, and meningitis n all patients...
  32. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..of multiple different autoimmune diseases including experimental autoimmune encephalitis, collagen-induced arthritis, and inflammatory bowel disease...
  33. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..medical challenges include cardiovascular diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating ..
  34. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..by demonstrating that autoreactive T cells from patients with multiple sclerosis, type-1 diabetes and rheumatoid arthritis are predominantly Kv1.3high TEM cells and that Kv1...
  35. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..physicians over several decades to treat inflammatory disorders including chronic fatigue syndrome, rheumatoid arthritis, asthma, neurological diseases and eczema, with little understanding as to why B12 supplementation is beneficial...
  36. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Current therapeutic approaches to rheumatoid arthritis ("RA") (corticosteroids, methotrexate, neutralization of TNF-?) rely upon broad-spectrum immunosuppression, an approach that is not uniformly ..
  37. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..two ZAP-70 mutants in the SKG and YYAA mice, I have defined a threshold for autoimmunity versus autoimmune arthritis. These findings were published in Journal of Experimental Medicine in 2009...
  38. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Veena Taneja; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Predisposition to develop Rheumatoid arthritis (RA) is associated with the presence of certain HLA class II genes while others offer resistance from arthritis...
  39. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..The broad spectrum of clinically important staphylococcal diseases includes also endocarditis, septic arthritis, toxic shock syndrome, scalded skin syndrome and food poisoning. S...
  40. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..approach to drug toxicity monitoring using methotrexate, the first-line treatment for patients with inflammatory arthritis, as a model drug...
  41. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer and rheumatoid arthritis (RA) share remarkably similar pathogenic pathways...
  42. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    CAROL A contact WALLACE; Fiscal Year: 2010
    ..Development of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) has created the opportunities multi-center retrospective and ..
  43. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..by applicant): HLA-DQ8 and DRB1*0401 molecules render humans and transgenic mice susceptible to develop arthritis while DRB1*0402 provide protection...
  44. TSAD AS AN EPOR/JAK2 ADAPTOR AND ERYTHROPOIETIC REGULATOR
    DONALD JOSEPH MCCRANN; Fiscal Year: 2010
    ..of TSAD in mouse primary bone marrow erythroid progenitor cells;and TSAD's associations with juvenile arthritis and chronic inflammatory polyradiculoneuropathy (each with associated anemia)...
  45. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..Headache, back pain, arthritis pain, tooth pain, cancer pain, and post-operative pain are just a few of the common conditions contributing to ..
  46. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..that these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing significant adverse effects. Aim.1...
  47. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..e., rheumatoid arthritis, systemic lupus erythematosus, and Sjvgren's syndrome)...
  48. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..ability to distinguish the roles of autoantibodies and inflammatory responses in the development of rheumatoid arthritis. BXD2 mice develop spontaneous erosive arthritis and generalized autoimmune disease...
  49. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..In this regard, the chronic inflammation occurring in inflammatory bowel disease and rheumatoid arthritis have many similarities to the chronic immunoinflammatory response in the oral cavity that destroys the soft and ..
  50. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..inflammation observed in animal models of autoimmune encephalomyelitis, allograft rejection, collagen-induced arthritis and graft vs. host disease...
  51. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..We will take advantage of an alliance of pediatric rheumatology investigators in the North America (Childhood Arthritis and Rheumatology Research Alliance, CARRA) to facilitate research in this rare population. We propose a 5-yr...
  52. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..contribute substantially to the immunopathogenesis of chronic systemic autoimmune diseases such as rheumatoid arthritis (RA), Sjogren's syndrome and systemic lupus erythematosus (SLE)...
  53. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..favor of multi-nucleated osteoclast formation causes bone destruction as observed in diseases such as autoimmune arthritis, periodontosis, postmenopausal osteoporosis, Padget's disease and bone tumor metastasis...
  54. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..trachomatis infections, including HIV-1 infection, cervical cancer and autoimmune-driven arthritis. The Specific Aims, then, of this Phase I application are to: 1) Develop a rapid method for genomic DNA ..
  55. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is the most common inflammatory joint disease of autoimmune etiology...
  56. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..He will draw on outstanding resources, including the VA Rheumatoid Arthritis national registry as well as the CTSA-supported Center for Clinical and Translational Research, and the Center ..
  57. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..These diseases would include not only bacterial sepsis, but diseases such as rheumatoid arthritis, diabetes, stroke, CNS cancers, and even obesity and Alzheimer's disease in which proinflammatory and ..
  58. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..As well as other chronic inflammatory diseases (rheumatoid arthritis, lupus, etc.), I hypothesize that HIF-11 inhibition may offer an exciting strategy for the management of asthma.
  59. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..the role of bone marrow as secondary lymphoid tissue) thereby bringing another autoimmune disease (Rheumatoid Arthritis) under the umbrella of the ACE. Finally, Dr...
  60. Control of alphavirous replacation in the nervous system
    Diane E Griffin; Fiscal Year: 2013
    ..viruses, most importantly alphaviruses and flaviviruses, cause widespread epidemics of fever, encephalitis and arthritis and pose increasing threats to human populations through expansion into new geographic areas...
  61. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..suggestions that inappropriate expression may contribute to pathologic inflammatory states such as rheumatoid arthritis or COPD...
  62. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arthritis (AR) is the leading cause of disability in the United States, with 50 million Americans (22%) suffering from some form of the disease or chronic joint symptoms...
  63. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] Rheumatoid arthritis (RA) is an immtmologically mediated, familial, chronically relapsing disease eventually resulting in joint destruction...
  64. ACTIVATION OF COLLAGENASE IN RHEUMATOID ARTHRITIS
    L Windsor; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the applicant's abstract) - Rheumatoid arthritis is characterized by chronic inflammation and joint degeneration...
  65. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..Title: Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis Project Summary/Abstract Rheumatoid arthritis (RA) is the most common inflammatory joint disease of autoimmune ..
  66. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..Unfortunately, diseases affecting the skeleton such as osteoporosis, rheumatoid arthritis, and cancer, tilt the delicate balance of bone destruction and bone formation toward the prior, leading to ..
  67. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ..provided by applicant): Humanized transgenic mice reproduce the disease evolution in severe RA Rheumatoid arthritis (RA) is a common autoimmune disease in humans genetically associated with specific HLA class II alleles...
  68. Pharmacogenetics of Methotrexate Therapy in Arthritis
    ALEXANDER WHITEHEAD; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Inflammatory diseases, including arthritis, are often associated with reduced life expectancy, due in part to an excess of cardiovascular disease deaths...
  69. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is one of the most common forms of arthritis, a potentially crippling autoimmune disease that affects more than two million Americans...
  70. Novel GPCR Kinase Interactions in Macrophages and Role in Arthritis
    Narayanan Parameswaran; Fiscal Year: 2009
    ..osteolysis (resorption or dissolution of bone due to inflammation) observed in disorders such as rheumatoid arthritis, osteoclasts erode periarticular bone, leading to joint collapse and disfigurement...
  71. Novel xanthine oxidase inhibitor for arthritis
    Zsuzsanna Zsengeller; Fiscal Year: 2004
    ..oxidase (XO)-catalyzed generation of superoxide anion is thought to contribute to the pathogenesis of autoimmune arthritis. The relative importance of XO to the pathogenesis of arthritis is demonstrated in numerous rodent models of ..
  72. ANTI-ANGIOGENIC GENE THERAPY FOR RHEUMATOID ARTHRITIS
    Noriyuki Kasahara; Fiscal Year: 2001
    ..of the angiogenesis inhibitors thrombospondin-1, angiostatin, and endostatin, for gene therapy of rheumatoid arthritis. Using lentiviral and helper-dependent adenoviral vectors as gene delivery systems for these angiogenesis ..
  73. Micellar VIP Nanoparticles for Rheumatoid Arthritis
    Israel Rubinstein; Fiscal Year: 2007
    Despite remarkable recent advances in therapeutics, rheumatoid arthritis still represents an unmet medical need...
  74. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..These transgenes were subsequently shown to confer susceptibility to collagen induced arthritis in normally resistant B10.M...