joint diseases

Summary

Top Publications

  1. ncbi Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis
    M A Salam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Lancet 352:522-7. 1998
  2. ncbi The contribution of adipose tissue and adipokines to inflammation in joint diseases
    Eric Toussirot
    Department of Rheumatology, Jean Minjoz University Hospital, Bd Fleming, F 25030 Besancon Cedex, France
    Curr Med Chem 14:1095-100. 2007
  3. ncbi Surgical treatment of femoroacetabular impingement: evaluation of the effect of the size of the resection
    Rodrigo M Mardones
    Department of Orthopedic Surgery and Orthopedic Biomechanics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Joint Surg Am 87:273-9. 2005
  4. ncbi Diagnostic and therapeutic injection of the hip and knee
    Dennis A Cardone
    Department of Family Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Am Fam Physician 67:2147-52. 2003
  5. ncbi Poor outcomes of isolated tibial insert exchange and arthrolysis for the management of stiffness following total knee arthroplasty
    G C Babis
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Bone Joint Surg Am 83:1534-6. 2001
  6. ncbi Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases
    Kaisa E Happonen
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, Sweden
    Immunobiology 217:1088-96. 2012
  7. ncbi Serum amyloid A isoforms in serum and synovial fluid from spontaneously diseased dogs with joint diseases or other conditions
    Mads Kjelgaard-Hansen
    Central Laboratory, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 3, DK 1870 Frederiksberg, Denmark
    Vet Immunol Immunopathol 117:296-301. 2007
  8. ncbi Simulated computerized adaptive tests for measuring functional status were efficient with good discriminant validity in patients with hip, knee, or foot/ankle impairments
    Dennis L Hart
    Focus On Therapeutic Outcomes, Inc, White Stone, VA 22578 2403, USA
    J Clin Epidemiol 58:629-38. 2005
  9. pmc Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Arthritis Res Ther 7:R817-24. 2005
  10. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005

Research Grants

  1. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
  2. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
  3. Patient-Specific Modeling of Total Knee Arthroplasty
    ROBERT ANTHONY SISTON; Fiscal Year: 2012
  4. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
  5. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2013
  6. Genetic and Genomic Dissection of Psoriatic Arthritis
    JAMES TILFORD ELDER; Fiscal Year: 2013
  7. Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ
    Kyle D Allen; Fiscal Year: 2013
  8. Using Intraoperative Measurements to Predict Postoperative Outcomes of TKA
    ROBERT ANTHONY SISTON; Fiscal Year: 2013
  9. TRAINING IN CARTILAGE RESEARCH
    THEODORE RICHARD OEGEMA; Fiscal Year: 2010
  10. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2009

Detail Information

Publications289 found, 100 shown here

  1. ncbi Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis
    M A Salam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka
    Lancet 352:522-7. 1998
    ..We undertook a randomised double-blind study to test the effects of ciprofloxacin treatment in children with shigella dysentery...
  2. ncbi The contribution of adipose tissue and adipokines to inflammation in joint diseases
    Eric Toussirot
    Department of Rheumatology, Jean Minjoz University Hospital, Bd Fleming, F 25030 Besancon Cedex, France
    Curr Med Chem 14:1095-100. 2007
    ..Thus, fat tissue is an active organ whose products contribute to inflammatory and degenerative processes underlying common joint diseases.
  3. ncbi Surgical treatment of femoroacetabular impingement: evaluation of the effect of the size of the resection
    Rodrigo M Mardones
    Department of Orthopedic Surgery and Orthopedic Biomechanics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Joint Surg Am 87:273-9. 2005
    ..A risk of this procedure is fracture. We evaluated the amount of resection of the anterolateral aspect of the femoral head-neck junction that can be done safely...
  4. ncbi Diagnostic and therapeutic injection of the hip and knee
    Dennis A Cardone
    Department of Family Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA
    Am Fam Physician 67:2147-52. 2003
    ..Persistent pain and disability from iliotibial band syndrome respond to local injection therapy. The proper technique, choice and quantity of pharmaceuticals, and appropriate follow-up are essential for effective outcomes...
  5. ncbi Poor outcomes of isolated tibial insert exchange and arthrolysis for the management of stiffness following total knee arthroplasty
    G C Babis
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Bone Joint Surg Am 83:1534-6. 2001
    ..We therefore have little enthusiasm for the continued use of this strategy...
  6. ncbi Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases
    Kaisa E Happonen
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, Wallenberg Laboratory, Skane University Hospital, Lund University, Sweden
    Immunobiology 217:1088-96. 2012
    ..Future challenges are to target the complement inhibition specifically to the joints to minimize systemic complement blockade...
  7. ncbi Serum amyloid A isoforms in serum and synovial fluid from spontaneously diseased dogs with joint diseases or other conditions
    Mads Kjelgaard-Hansen
    Central Laboratory, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 3, DK 1870 Frederiksberg, Denmark
    Vet Immunol Immunopathol 117:296-301. 2007
    ..In synovial fluid from inflamed joints one or more highly alkaline SAA isoforms (with apparent isoelectric points above 9.3) were identified, with data suggesting local production of these isoforms in the canine inflamed joint...
  8. ncbi Simulated computerized adaptive tests for measuring functional status were efficient with good discriminant validity in patients with hip, knee, or foot/ankle impairments
    Dennis L Hart
    Focus On Therapeutic Outcomes, Inc, White Stone, VA 22578 2403, USA
    J Clin Epidemiol 58:629-38. 2005
    ....
  9. pmc Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
    Rille Pullerits
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Arthritis Res Ther 7:R817-24. 2005
    ..Blood from 45 healthy individuals, synovial fluid samples from 33 patients with non-inflammatory joint diseases and blood from six patients with non-inflammatory joint diseases were used for comparison...
  10. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
  11. ncbi Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases
    Athan Baillet
    GREPI CNRS UMR 5525, Grenoble University, Grenoble, France
    Rheumatology (Oxford) 49:671-82. 2010
    ..We investigated SF and serum proteomic fingerprints of patients suffering from RA, OA and other miscellaneous inflammatory arthritides (MIAs) in order to identify RA-specific biomarkers...
  12. ncbi Genetic variation and genetic trends in hip and elbow dysplasia in Swedish Rottweiler and Bernese Mountain Dog
    S Malm
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Anim Breed Genet 125:403-12. 2008
    ..Based on the results, a statistical model for routine prediction of breeding values for HD and ED in Swedish dogs was suggested...
  13. ncbi Role of obesity on the risk for total hip or knee arthroplasty
    Robert Bourne
    University of Western Ontario, London, ON, Canada
    Clin Orthop Relat Res 465:185-8. 2007
    ..9 kg/m2); and 32.73- (TKA) and 8.56-fold (THA) higher for people in obese Class III group (body mass index > 40 kg/m2). Thus, our data support an association between obesity and subsequent THA and TKA...
  14. ncbi CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome
    J Marcelino
    Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Nat Genet 23:319-22. 1999
    ..The similarity of CACP sequence to that of other protein families and the expression of CACP in non-skeletal tissues suggest it may have diverse biological activities...
  15. ncbi Joint diseases and matrix metalloproteinases: a role for MMP-13
    Hironari Takaishi
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Curr Pharm Biotechnol 9:47-54. 2008
    ..This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis...
  16. ncbi Diagnostics of femoroacetabular impingement and labral pathology of the hip: a systematic review of the accuracy and validity of physical tests
    Marsha Tijssen
    Sport Medisch Centrum Papendal, Papendallaan 7, Arnhem, The Netherlands
    Arthroscopy 28:860-71. 2012
    ..The purpose of this systematic review was to identify the diagnostic accuracy and validity of physical tests that are used to assess FAI and labral pathology of the hip joint...
  17. ncbi P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
    ..Our results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins independently of its proinflammatory actions via IL-1 cytokines...
  18. ncbi Total knee arthroplasty in hemophilic arthropathy
    John M Norian
    University of California, San Francisco, San Francisco, CA 94143, USA
    J Bone Joint Surg Am 84:1138-41. 2002
    ..The purpose of this study was to evaluate prosthetic survival following total knee arthroplasty and identify factors associated with failures of the arthroplasties in hemophilic patients...
  19. ncbi Triangular fibrocartilage complex lesions: a classification
    A K Palmer
    Department of Orthopaedic Surgery, SUNY Health Science Center, Syracuse 13202
    J Hand Surg Am 14:594-606. 1989
    ..Degenerative lesions are classified by the location and severity of degenerative changes of the triangular fibrocartilage complex, ulnar head, ulnocarpal bones and lunotriquetral ligament...
  20. ncbi Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
    Marilyn J Manco-Johnson
    University of Colorado and Health Sciences Center, Denver, USA
    N Engl J Med 357:535-44. 2007
    ..Effective ways to prevent arthropathy in severe hemophilia are unknown...
  21. ncbi Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee
    Mininder S Kocher
    Steadman Hawkins Sports Medicine Foundation, Vail, Colorado 81657, USA
    J Bone Joint Surg Am 86:1139-45. 2004
    ..The purpose of this study was to determine the psychometric properties of the Lysholm knee scale for various chondral disorders of the knee...
  22. ncbi [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]
    Jean Yves Jouzeau
    UMR CNRS Nancy Université, France
    J Soc Biol 202:289-312. 2008
    ..These anti-inflammatory and anti-catabolic properties were confirmed in animal models of joint diseases where PPAR agonists reduced synovial inflammation while preventing cartilage destruction or inflammatory bone ..
  23. ncbi Diagnostic accuracy of clinical tests of the hip: a systematic review with meta-analysis
    Michael P Reiman
    Community and Family Practice, Duke University School of Medicine, Durham, NC 27705, USA
    Br J Sports Med 47:893-902. 2013
    ..Useful clinical utility is necessary to support diagnostic imaging and subsequent surgical decision making...
  24. ncbi Deficits in shoulder function and general health associated with sixteen common shoulder diagnoses: a study of 2674 patients
    Mauricio Largacha
    Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Shoulder Elbow Surg 15:30-9. 2006
    ..The magnitude of these deficits correlated significantly with gender and diagnosis but not with age...
  25. ncbi Evidence-based indications for elbow arthroscopy
    Kwan M Yeoh
    Hand and Upper Limb Centre, St Joseph s Health Care, University of Western Ontario, London, Ontario, Canada
    Arthroscopy 28:272-82. 2012
    ..Our hypothesis was that the evidence would support the use of elbow arthroscopy in the management of common elbow conditions...
  26. ncbi Shoulder arthroplasty: evolving techniques and indications
    Gilles Walch
    Hôpital privé Jean Mermoz, Centre Orthopedique Santy, 24, Avenue Paul Santy, 69008 Lyon, France
    Joint Bone Spine 77:501-5. 2010
    ....
  27. ncbi Diagnostic values of tests for acromioclavicular joint pain
    Judie Walton
    Sports Medicine and Shoulder Service, Orthopaedic Research Institute, St George Hospital Campus, University of New South Wales, Kogarah, Sydney, New South Wales 2217, Australia
    J Bone Joint Surg Am 86:807-12. 2004
    ..This prospective study was performed to determine which clinical and imaging tests were most helpful for diagnosing acromioclavicular joint pain...
  28. ncbi Impact of multiple joint impairments on the energetics and mechanics of walking in patients with haemophilia
    S Lobet
    Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Haemophilia 19:e66-72. 2013
    ..Metabolic variables were probably the most representative variables of gait disability for these subjects with complex orthopaedic degenerative disorders...
  29. ncbi Hemophilia joint health score reliability study
    P Hilliard
    Department of Rehabilitation Service, The Division of Rheumatology, The Hospital for Sick Children, University of Toronto, Canada
    Haemophilia 12:518-25. 2006
    ..To address these concerns, the Hemophilia Joint Health Score (HJHS) was developed by modifying existing scores...
  30. ncbi Inter- and intra-observer reliability of radiographic scores commonly used for the evaluation of haemophilic arthropathy
    M Silva
    Hemophilia Center at Orthopaedic Hospital, Los Angeles, CA 90007, USA
    Haemophilia 14:504-12. 2008
    ..Improvements, either through education or modification of the scoring systems, are critical in an era where correlations between clinical and radiographic scores have received significant attention...
  31. ncbi Natural progression of blood-induced joint damage in patients with haemophilia: clinical relevance and reproducibility of three-dimensional gait analysis
    S Lobet
    Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Haemophilia 16:813-21. 2010
    ..The kinematic variables were reproducible in both the sagittal and frontal planes. In conclusion, 3DGA is a reproducible tool to assess abnormal gait patterns and monitor natural disease progression in haemophilic patients...
  32. ncbi Anteromedial impingement in the ankle joint: outcomes following arthroscopy
    Christopher D Murawski
    Hospital for Special Surgery, New York, New York, USA
    Am J Sports Med 38:2017-24. 2010
    ..To the best of the authors' knowledge, this is the first case series reporting the outcomes following arthroscopic resection of anteromedial impingement...
  33. ncbi Body structure versus body function in haemophilia: the case of haemophilic ankle arthropathy
    S Lobet
    Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Haemophilia 17:508-15. 2011
    ..Functional assessments such as 3DGA should be used more frequently when monitoring the progression of ankle arthropathy or the effects of therapeutic interventions in adult haemophilia patients...
  34. ncbi Comparison of biomechanical gait parameters of young children with haemophilia and those of age-matched peers
    D Stephensen
    School of Health and Bioscience, University of East London, London, UK
    Haemophilia 15:509-18. 2009
    ..Protocols and quantitative data on the biomechanical gait pattern of children with haemophilia reported in this study provide a baseline to evaluate lower limb joint function and clinical progression...
  35. ncbi [Joint contractures in older age. A systematic literature review]
    I Gnass
    Institut für Pflegewissenschaft, Fakultät für Medizin, Universitat Witten Herdecke, Witten, Deutschland
    Z Gerontol Geriatr 43:147-57. 2010
    ..Therefore, it is necessary to have a clear definition of contracture. The goal of this literature review was to identify definitions of contractures used in controlled trials...
  36. ncbi Functional impact of custom-made foot orthoses in patients with haemophilic ankle arthropathy
    S Lobet
    Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Haemophilia 18:e227-35. 2012
    ..Self-reported clinical tools such as FFI-R and satisfaction questionnaires are sufficiently sensitive for assessing the efficacy of foot orthoses in PWH...
  37. ncbi Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy
    B Lundin
    Department of Radiology, University Hospital of Lund, Lund, Sweden
    Haemophilia 11:109-15. 2005
    ..The use of these two compatible scales for progressive and additive MRI assessments can facilitate international comparison of data and enhance the accumulation of experience on MRI scoring of haemophilic arthropathy...
  38. ncbi MR imaging of ankle impingement lesions
    James Linklater
    Castlereagh Sports Imaging, North Sydney Orthopaedic and Sports Medicine Centre, 286 Pacific Highway, Crows Nest, NSW 2065, Australia
    Magn Reson Imaging Clin N Am 17:775-800, vii-viii. 2009
    ....
  39. ncbi Joint health and functional ability in children with haemophilia who receive intensive replacement therapy
    W Groen
    Child Development and Exercise Center, University Medical Center Utrecht, University Children s Hospital, Utrecht, The Netherlands
    Haemophilia 17:783-90. 2011
    ..Mild abnormalities in ankle assessment by HJHS may lead to functional loss. Therefore, ankle joints may warrant special attention in the follow up of these children...
  40. ncbi Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy
    Sébastien Lobet
    Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium
    Clin Biomech (Bristol, Avon) 27:625-31. 2012
    ..The purpose of this study was to assess the impact of ankle osteoarthritis on the energetics and mechanics of gait, while taking into account the effect of slower speed generally adopted by patients with osteoarthritis...
  41. ncbi Antisense strategies in degenerative joint diseases: sense or nonsense?
    Lars C Huber
    Center of Experimental Rheumatology, WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University of Zurich, University Hospital Zurich, Gloriastr 23, CH 8091 Zurich, Switzerland
    Adv Drug Deliv Rev 58:285-99. 2006
    ..In the context of degenerative joint diseases, experimental data in the field of antisense strategies are still rare...
  42. ncbi Physiotherapy following elective orthopaedic procedures
    P De Kleijn
    UMC Utrecht, Utrecht, The Netherlands
    Haemophilia 12:108-12. 2006
    ..Both pre- and postoperative physiotherapy, as part of comprehensive care is needed to achieve optimal functional outcome and therefore optimal quality of life for people with haemophilia...
  43. ncbi Shoulder arthroplasty in cases with avascular necrosis of the humeral head
    Robert M Orfaly
    Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, OR 97239, USA
    J Shoulder Elbow Surg 16:S27-32. 2007
    ..Shoulder arthroplasty for AVN produces good pain relief and function, although a concurrent series with osteoarthritis yielded better results. Forward elevation did not approach normal as had been previously reported...
  44. ncbi Indications and reoperation rates for total elbow arthroplasty: an analysis of trends in New York State
    David M Gay
    Flagler Orthopedics and Sports Medicine, 61 Memorial Medical Parkway, Palm Coast, FL 32164, USA
    J Bone Joint Surg Am 94:110-7. 2012
    ..The purposes of this study were to evaluate the changes with time in the indications for total elbow arthroplasty and to examine the complications of this procedure in a large database...
  45. ncbi A candidate gene study of canine joint diseases
    Dylan N Clements
    Division of Veterinary Clinical Sciences, The Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, UK
    J Hered 101:54-60. 2010
    ..The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation...
  46. ncbi Genetic analysis of three different classification protocols for the evaluation of elbow dysplasia in German shepherd dogs
    V Janutta
    Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    J Small Anim Pract 47:75-82. 2006
    ..Three different scoring systems for elbow dysplasia and its radiographic signs were genetically evaluated in 2645 German shepherd dogs...
  47. ncbi Differential diagnosis of pedal osteomyelitis and diabetic neuroarthropathy: MR Imaging
    Hans Peter Ledermann
    Universitatsspital Basel, Dep diagn Radiologie, Basel, Switzerland
    Semin Musculoskelet Radiol 9:272-83. 2005
    ..Presence of a sinus tract, disappearance of subchondral cysts, diffuse bone marrow abnormality, and bone erosions are in favor of infection...
  48. ncbi Cross-linked glenoid prosthesis: a wear comparison to conventional glenoid prosthesis with wear particulate analysis
    Michael A Wirth
    Department of Orthopaedics, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78284, USA
    J Shoulder Elbow Surg 18:130-7. 2009
    ..The results of this study support the use of cross-linked UHMWPE glenoids in clinical applications...
  49. pmc Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty: a systematic review
    Pasqualina L Santaguida
    Evidence Based Practice Centre, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario
    Can J Surg 51:428-36. 2008
    ..This study addresses how patient characteristics influence the outcomes of hip and knee arthroplasty in patients with osteoarthritis...
  50. ncbi Incidence rates of dislocation, pulmonary embolism, and deep infection during the first six months after elective total hip replacement
    Charlotte B Phillips
    Robert Breck Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 85:20-6. 2003
    ..As a result, a greater proportion of complications occurs following discharge. Data on the incidence trends of major complications of total hip replacement would facilitate recognition and management of these adverse events...
  51. ncbi Total knee arthroplasty in hemophilic arthropathy
    Isabelle Legroux-Gerot
    Rheumatology Department, CHRU Lille, Hopital Roger Salengro, 59037 Lille Cedex, France
    Joint Bone Spine 70:22-32. 2003
    ..Chronic arthropathy causes major functional disability in patients with severe hemophilia...
  52. ncbi Ulnar-sided wrist pain: evaluation and treatment of triangular fibrocartilage complex tears, ulnocarpal impaction syndrome, and lunotriquetral ligament tears
    Kavi Sachar
    Hand Surgery Associates, Denver, CO 80210, USA
    J Hand Surg Am 33:1669-79. 2008
    ..Common causes of ulnar-sided wrist pain include triangular fibrocartilage complex injuries, lunotriquetral ligament injuries, and ulnar impaction syndrome...
  53. ncbi No superiority of cemented metal-on-metal vs metal-on-polyethylene THA at 5-year follow-up
    Wierd P Zijlstra
    Department of Orthopedic Surgery, Martini Hospital, Groningen, The Netherlands
    Orthopedics 32:479. 2009
    ..At 5-year follow-up, cemented metal-on-metal THA showed no clinical superiority over metal-on-polyethylene THA...
  54. ncbi Bilateral knee lipoma arborescens: a case report
    C H Yan
    Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Orthop Surg (Hong Kong) 16:107-10. 2008
    ..Magnetic resonance imaging is useful in differentiating lipoma arborescens from other intra-articular lesions in patients with recurrent knee pain and swelling...
  55. ncbi Concentration and localization of YKL-40 in hip joint diseases
    M Kawasaki
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan
    J Rheumatol 28:341-5. 2001
    ..We evaluated the concentrations and localization of YKL-40 in hip joint diseases, and analyzed the possibility of YKL-40 as a new inflammatory joint marker...
  56. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
    ..The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments...
  57. ncbi Rotator cuff tear arthropathy
    Kier J Ecklund
    Department of Orthopaedic Surgery, University of California, Irving, Orange 92868, USA
    J Am Acad Orthop Surg 15:340-9. 2007
    ..Recent studies, however, report promising experience with reverse ball-and-socket arthroplasty...
  58. ncbi Total knee replacement in haemophilic arthropathy
    E C Rodriguez-Merchan
    Department of Orthopaedics and Haemophilia Unit, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain
    J Bone Joint Surg Br 89:186-8. 2007
    ..Our rate of infection was lower than previously reported. This could be due to better control of the HIV status with highly active anti-retroviral therapy and the use of antibiotic-loaded cement...
  59. ncbi The effect of total shoulder arthroplasty on self-assessed health status is comparable to that of total hip arthroplasty and coronary artery bypass grafting
    Richard S Boorman
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98195 6500, USA
    J Shoulder Elbow Surg 12:158-63. 2003
    ..05). Although the improvements were significant and similar to the postoperative scores reported for total hip arthroplasty and coronary bypass procedures, the scores did not reach those of the general population...
  60. ncbi Use of daptomycin to treat drug-resistant Gram-positive bone and joint infections
    Michael S Finney
    Fountain Valley Regional Hospital, Fountain Valley, CA, USA
    Curr Med Res Opin 21:1923-6. 2005
    ..This report describes the experience in a series of cases of the use of a novel antibiotic, daptomycin, for the treatment of bone and joint infections...
  61. ncbi Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial
    U Horas
    Department of Trauma Surgery, University of Giessen, Germany
    J Bone Joint Surg Am 85:185-92. 2003
    ..The purpose of this study was to evaluate the clinical and histological outcomes of these two techniques...
  62. ncbi Mucoid degeneration of the anterior cruciate ligament--a report of two cases
    Makoto Nishimori
    Department of Orthopedic Surgery, JA Onomichi General Hospital, Onomichi, Hiroshima 722 8508, Japan
    Magn Reson Imaging 22:1325-8. 2004
    ..If this disease is considered preoperatively, it can be diagnosed easily based on characteristic findings...
  63. ncbi Bilateral lipoma arborescens of the subdeltoid bursa
    T Pandey
    Department of Radiology, Al Razi Hospital, Kuwait
    Australas Radiol 50:487-9. 2006
    ..Magnetic resonance imaging is a very effective method for the diagnosis of this rare condition because of its ability to do tissue characterization...
  64. ncbi The risk of revision after primary total hip arthroplasty among statin users: a nationwide population-based nested case-control study
    Theis M Thillemann
    Department of Orthopedics, Aarhus University Hospital, Aarhus N, Denmark
    J Bone Joint Surg Am 92:1063-72. 2010
    ..The association between statin use and the risk of revision after primary total hip arthroplasty has not been examined...
  65. ncbi Receptor for advanced glycation end products on human synovial fibroblasts: role in the pathogenesis of dialysis-related amyloidosis
    Fan Fan Hou
    Division of Nephrology, Nanfang Hospital, Guangzhou, People s Republic of China
    J Am Soc Nephrol 13:1296-306. 2002
    ..These data provide evidence of RAGE-mediated perturbation of human synoviocytes, which may be involved in the pathogenesis of inflammatory processes associated with DRA...
  66. ncbi Magnetic resonance imaging and magnetic resonance arthrography of the shoulder: dependence on the level of training of the performing radiologist for diagnostic accuracy
    John S Theodoropoulos
    Division of Orthopaedics, Mount Sinai Hospital and the University Health Network, University of Toronto, Room 476c, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
    Skeletal Radiol 39:661-7. 2010
    ..The purpose of this study was to evaluate the diagnostic performance of MR imaging examinations of the shoulder with regard to the training level of the performing radiologist...
  67. ncbi The ulnar impaction syndrome: follow-up of ulnar shortening osteotomy
    S Chun
    State University of New York, Department of Orthopedic Surgery, Syracuse 13202
    J Hand Surg Am 18:46-53. 1993
    ..Complications were rare, with no ulnar nonunions. This long-term follow-up study revealed that distal ulnar shortening osteotomy is an excellent procedure for the treatment of ulnar impaction syndrome...
  68. ncbi Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review
    E U Sumer
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 11:485-506. 2006
    ..non-invasive diagnostic tools for the monitoring of changes in cartilage turnover in patients with destructive joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA)...
  69. ncbi Patients' expectations of knee surgery
    C A Mancuso
    Department of Orthopaedics Surgery, Hospital for Special Surgery, New York, NY 10021, USA
    J Bone Joint Surg Am 83:1005-12. 2001
    ..Reexamining patients' responses postoperatively could provide a way to assess fulfillment of expectations, which is a crucial patient-derived measure of outcome and satisfaction...
  70. ncbi Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data
    Judith Sendzik
    Institut fur Klinische Pharmakologie und Toxikologie, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Antimicrob Agents 33:194-200. 2009
    ..complicated urinary tract infections and enteritis caused by invasive multidrug-resistant pathogens (e.g. Salmonella, Shigella)...
  71. ncbi Measurement of equine myeloperoxidase (MPO) activity in synovial fluid by a modified MPO assay and evaluation of joint diseases - an initial case study
    S Fietz
    Institute of Veterinary Biochemistry, Freie Universitat Berlin, Oertzenweg 19b, D 14163 Berlin, Germany
    Res Vet Sci 84:347-53. 2008
    ..assay in the synovial fluid of horses and investigate whether MPO activity is increased in different forms of joint diseases. Synovial fluid samples were taken from affected joints from horses with osteoarthritis, chronic non-septic ..
  72. ncbi Diagnosis and relation to general health of shoulder disorders presenting to primary care
    A J K Ostor
    Rheumatology Research Unit, Box 194, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Rheumatology (Oxford) 44:800-5. 2005
    ..To prospectively evaluate the incidence, spectrum of disease and relation to general health of shoulder disorders in primary care...
  73. ncbi Hip disease and the prognosis of total hip replacements. A review of 53,698 primary total hip replacements reported to the Norwegian Arthroplasty Register 1987-99
    O Furnes
    Haukeland University Hospital, Bergen, Norway
    J Bone Joint Surg Br 83:579-86. 2001
    ..If a cemented Charnley prosthesis is used, the type of disease leading to THR seems in most cases to have only a minor influence on the survival of the prosthesis...
  74. ncbi Tendon or joint disorders in children after treatment with fluoroquinolones or azithromycin
    Chuen L Yee
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Pediatr Infect Dis J 21:525-9. 2002
    ....
  75. ncbi Ulnar shortening osteotomy in idiopathic ulnar impaction syndrome
    Goo Hyun Baek
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    J Bone Joint Surg Am 87:2649-54. 2005
    ..The purpose of this study was to evaluate the clinical features of idiopathic ulnar impaction syndrome and the outcomes of ulnar shortening osteotomy for this group of patients...
  76. ncbi A placebo-controlled double-blind study on the effect of nutraceuticals (chondroitin sulfate and mussel extract) in dogs with joint diseases as perceived by their owners
    Britta Dobenecker
    Institute for Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximilians Universitat, Munich, Germany
    J Nutr 132:1690S-1S. 2002
  77. ncbi Outcome after total hip arthroplasty: Part II. Disease-specific follow-up and the Swedish National Total Hip Arthroplasty Register
    P Söderman
    Department of Orthopedics, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Orthop Scand 72:113-9. 2001
    ....
  78. ncbi Effects of ciprofloxacin on joint cartilage in immature dogs immediately after dosing and after a 5-month treatment-free period
    Eckhard von Keutz
    PH PDP Toxicology, Pharma Research Center, Bayer HealthCare AG, Aprather Weg, 42096, Wuppertal, Germany
    Arch Toxicol 78:418-24. 2004
    ....
  79. ncbi 7: Soft tissue, bone and joint infections
    Thomas Gottlieb
    Department of Microbiology and Infectious Diseases, Concord Hospital, Sydney, NSW
    Med J Aust 176:609-15. 2002
    ..Osteomyelitis often complicates diabetic foot infection with ulceration and is rarely cured by antibiotics alone; early surgical intervention achieves the best outcome...
  80. ncbi Factors affecting results of ulnar shortening for ulnar impaction syndrome
    Norimasa Iwasaki
    Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Clin Orthop Relat Res 465:215-9. 2007
    ..5 points). A long duration of symptoms and workers' compensation predicted worse clinical scores. We recommend considering these two factors when deciding whether to perform this procedure...
  81. pmc THA with Delta ceramic on ceramic: results of a multicenter investigational device exemption trial
    William G Hamilton
    Anderson Orthopaedic Research Institute, 2501 Parkers Lane, Alexandria, VA 22306, USA
    Clin Orthop Relat Res 468:358-66. 2010
    ..In the short term, the Delta COC articulation provided similar functional scores and survivorship and complication rates with the ceramic head mated with crosslinked polyethylene...
  82. ncbi Manipulation with prolonged epidural analgesia for treatment of TKA complicated by arthrofibrosis
    Gerardo Mangino Pariente
    Joint Implant Surgeons, Inc, Hospital ABC Sante Fe, Mexico
    Surg Technol Int 15:221-4. 2006
    ..Although not without complications, manipulation under epidural anesthesia represents a viable option for treatment of persistent stiffness after TKA; 80% of these difficult cases achieved successful results...
  83. ncbi Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases
    Elvire Gouze
    Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, Florida 32610, USA
    Mol Ther 15:1114-20. 2007
    Local gene therapy for chronic joint diseases requires prolonged transgenic expression, but this has not been reliably achieved in animal models...
  84. ncbi Anterolateral ankle impingement: mr arthrographic assessment of the anterolateral recess
    P Robinson
    Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, University of Toronto, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Radiology 221:186-90. 2001
    ..CONCLUSION: MR arthrography of the tibiotalar joint is accurate in assessing the anterolateral recess of the ankle...
  85. pmc Clinimetric evaluation of shoulder disability questionnaires: a systematic review of the literature
    S D M Bot
    VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 63:335-41. 2004
    ..To identify all available shoulder disability questionnaires designed to measure physical functioning and to evaluate evidence for the clinimetric quality of these instruments...
  86. ncbi Anterior femoroacetabular impingement after femoral neck fractures
    H Eijer
    Department of Orthopaedics, University Hospital, Inselspital, Bern, Switzerland
    J Orthop Trauma 15:475-81. 2001
    ..Early treatment is essential to prevent further degeneration and osteoarthrosis of the joint. Prevention is predicated by initial precise anatomic reduction of such fractures in all planes...
  87. ncbi Stiffness after total knee arthroplasty
    Richard S Laskin
    The Institute for Hip and Knee Replacement, Hospital for Special Surgery, New York, New York 10021, US
    J Arthroplasty 19:41-6. 2004
    ..Although most patients achieve a postoperative flexion that is highly correlated to that which was present preoperatively, factors such as pain, obesity, and deformities of adjacent joints may limit such motion...
  88. ncbi Arthrodesis of the knee
    Janet D Conway
    Rubin Institute for Advanced Orthopaedics, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    J Bone Joint Surg Am 86:835-48. 2004
    ..Patient function after arthrodesis of the knee is superior to that after above-the-knee amputation. Conversion of a solid knee fusion to a total knee arthroplasty has a substantial complication rate...
  89. ncbi Antibiotic treatment of gram-positive bone and joint infections
    Elizabeth S R Darley
    Bristol Centre for Antimicrobial Research and Evaluation, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
    J Antimicrob Chemother 53:928-35. 2004
    ..Individual case reports describe successful treatment using the newer antibiotics, e.g. linezolid and quinupristin/dalfopristin, but results of clinical trials are awaited...
  90. ncbi The complete type of suprapatellar plica in a professional baseball pitcher: consideration of a cause of anterior knee pain
    Nobuo Adachi
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Arthroscopy 20:987-91. 2004
    ..We consider that the main cause of his anterior knee pain was cartilaginous damage on the patella and the trochlea, which might be accelerated by the existence of the suprapatellar plica that reduced the mobility of the patella...
  91. ncbi Perspectives on the use of gene therapy for chronic joint diseases
    Steven C Ghivizzani
    Gene Therapy Laboratory, Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville FL 32610, USA
    Curr Gene Ther 8:273-86. 2008
    ..inhibitors, and intracellular signalling molecules that could be of great benefit in the treatment of chronic joint diseases, such as osteo- and rheumatoid arthritis...
  92. ncbi Synovitis and soft tissue impingement of the ankle: assessment with enhanced three-dimensional FSPGR MR imaging
    Yong Min Huh
    Department of Diagnostic Radiology, Brain Korea 21 Project for Medical Science, Yonsei University, College of Medicine, Seoul, Korea
    J Magn Reson Imaging 19:108-16. 2004
    ....
  93. ncbi Bone and joint infections in the elderly: practical treatment guidelines
    J T Mader
    The Marine Biomedical Institute, Division of Marine Medicine, University of Texas Medical Branch, Galveston 77555 1115, USA
    Drugs Aging 16:67-80. 2000
    ....
  94. ncbi Can long-term prophylaxis for severe haemophilia be stopped in adulthood? Results from Denmark and the Netherlands
    K van Dijk
    Van Creveldkliniek, UMC Utrecht, The Netherlands
    Br J Haematol 130:107-12. 2005
    ..In conclusion one-third of young adults with severe haemophilia on a prophylactic regimen discontinued prophylaxis in early adulthood, while maintaining a low joint bleed frequency and similar arthropathy after 4 years...
  95. ncbi Blood-induced joint damage in hemophilia
    Goris Roosendaal
    Van Creveldkliniek and National Hemophilia Center, Division of Internal Medicine, University Medical Center Utrecht, The Netherlands
    Semin Thromb Hemost 29:37-42. 2003
    ..Thus, both processes occur in parallel, and although they influence each other they probably do not depend on each other. This concept resembles degenerative joint damage as found in osteoarthritis...
  96. ncbi Ultrasound of the shoulder
    B Daenen
    Medical Imaging Department, CHC, Liege, Belgium
    JBR-BTR 90:325-37. 2007
    ..This article will review shoulder anatomy and examination technique and the different pathologies that can be assessed by ultrasound...
  97. ncbi Anterior femoro-acetabular impingement due to acetabular retroversion. Treatment with periacetabular osteotomy
    K A Siebenrock
    Department of Orthopaedic Surgery, University of Berne, Inselspital, Switzerland
    J Bone Joint Surg Am 85:278-86. 2003
    ..This study was performed to evaluate whether symptomatic anterior femoro-acetabular impingement due to acetabular retroversion can be treated effectively with a periacetabular osteotomy...
  98. ncbi Soft-tissue and osseous impingement syndromes of the ankle: role of imaging in diagnosis and management
    Philip Robinson
    Department of Radiology, St James University Hospital, Beckett St, Leeds LS9 7TF, England
    Radiographics 22:1457-69; discussion 1470-1. 2002
    ..CT and MR arthrographic techniques allow the most accurate assessment of the capsular recesses, albeit with important limitations in diagnosis of clinical impingement syndromes...
  99. ncbi Ultrasound evaluation of the shoulder
    Srinivas Kolla
    Department of Radiology, SUNY Downstate, Brooklyn, New York 11203, USA
    Semin Musculoskelet Radiol 11:117-25. 2007
    ..This article discusses ultrasound examination of the shoulder and highlights some of its utility. The focus is on normal shoulder anatomy and pathology involving the rotator cuff, biceps tendon, and other related miscellaneous conditions...
  100. ncbi MR imaging of cysts, ganglia, and bursae about the knee
    Francesca D Beaman
    Center Radiology, PC, Washington Hospital Center, Washington, DC 20010, USA
    Radiol Clin North Am 45:969-82, vi. 2007
    ..For the purpose of this article, the authors limit the scope of their discussion to benign cysts, ganglia, and bursae about the knee...
  101. ncbi Stem cell therapy for joint problems using the horse as a clinically relevant animal model
    Thomas G Koch
    University of Guelph, Department of Biomedical Sciences, Ontario Veterinary College, Guelph, ON, N1G 2W1, Canada
    Expert Opin Biol Ther 7:1621-6. 2007
    ..Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process...

Research Grants62

  1. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..Monitoring muscle viscosity could help in anticipating joint diseases, such as tendonitis, bursitis and osteoarthritis and decreasing the probability of osteoporotic bone fracture...
  2. Lubricin Function in Articulating Joints
    Matthew L Warman; Fiscal Year: 2012
    ..We have observed acquired alterations of lubricin in patients with common joint diseases, including osteoarthritis, rheumatoid arthritis, and traumatic joint injury...
  3. Patient-Specific Modeling of Total Knee Arthroplasty
    ROBERT ANTHONY SISTON; Fiscal Year: 2012
    ..TKA is a common surgical procedure used to treat degenerative joint diseases such as osteoarthritis...
  4. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2009
    ..Articular cartilage destruction is a central factor in the pathogenesis of joint diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA)...
  5. The role of microRNAs in chondrogenesis and arthritis
    Hiroshi Asahara; Fiscal Year: 2013
    ..Articular cartilage destruction is a central factor in the pathogenesis of joint diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA)...
  6. Genetic and Genomic Dissection of Psoriatic Arthritis
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..provided by applicant): Psoriatic arthritis (PsA) is distinctive amongst the inflammatory/autoimmune joint diseases in that its onset is commonly preceded by cutaneous psoriasis (PsC)...
  7. Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ
    Kyle D Allen; Fiscal Year: 2013
    in degenerative joint diseases, the articiilating surfaces of a joint are gradually destroyed, ultimately resulting in pain and joint dysfunction...
  8. Using Intraoperative Measurements to Predict Postoperative Outcomes of TKA
    ROBERT ANTHONY SISTON; Fiscal Year: 2013
    ..outcomes following total knee arthroplasty (TKA), a common surgical procedure used to treat degenerative joint diseases such as osteoarthritis...
  9. TRAINING IN CARTILAGE RESEARCH
    THEODORE RICHARD OEGEMA; Fiscal Year: 2010
    ..derived from different joints and different regions of cartilage, as well as animal models for degenerative joint diseases. Most students pursue a PhD in Biochemistry and in addition to rigorous research training, obtain a broad ..
  10. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2009
    ..cartilage, such as magnetic resonance imaging (MRI), are essential for defining the natural history of these joint diseases and for evaluating the effects of preventive and therapeutic interventions...
  11. Design of an Engineered Cartilage Biocomposite for Joint Rehabilitation
    Bahar Bilgen; Fiscal Year: 2012
    ..The broader impact is that the developed techniques are anticipated to treat degenerative joint diseases and prevent joint replacement surgeries, thus impacting nearly half of the population.
  12. IBMS Sun Valley Workshop on Musculoskeletal Biology
    David B Burr; Fiscal Year: 2013
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases;(2) develop a dialogue between basic and clinical investigators;(3) provide training workshops for junior ..
  13. 2013 Cartilage Biology and Pathology: Formation, Structure, Function, and Regener
    Rocky S Tuan; Fiscal Year: 2013
    ..ranging from death near the time of birth to reduced growth of the skeleton during childhood, and degenerative joint diseases and physical disability in adults...
  14. COBRE for Skeletal Health and Repair
    Qian Chen; Fiscal Year: 2013
    ..Project 2 examine how joint cartilage degenerates in adult joint diseases. Project 3 develops novel strategies of harvesting stem cells from fat tissues to repair bone...
  15. A New Biomechanical Model to Examine Joint Control Adaptations during Running in
    Jae Kun Shim; Fiscal Year: 2013
    ..adaptations of running with an RSP may put this group at risk for physical injuries and degenerative joint diseases, as suggested by our preliminary data and previous studies...
  16. ELECTROSTATIC SURFACE OPTIMIZATION FOR OSSEOINTEGRATION
    Michele Marcolongo; Fiscal Year: 2000
    Debilitating degenerative joint diseases are routinely treated by joint replacements to allow restoration of relatively pain-free motion to the affected joint...
  17. Sun Valley Workshop: Musculoskeletal Biology
    David B Burr; Fiscal Year: 2012
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases;(2) develop a dialogue between basic and clinical investigators;(3) provide training workshops for junior ..
  18. Skyscan 1172 ex-vivo microComputed Tomography System
    Nicola C Partridge; Fiscal Year: 2013
    ..A group of 13 funded faculties from the NYUCD, NYUSoM and the NYU-Hospital for Joint Diseases (HJD) are identified as major initial users of the ex-vivo micro CT...
  19. Sun Valley Workshop on Skeletal Biology
    David B Burr; Fiscal Year: 2011
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases;(2) develop a dialogue between basic and clinical investigators;(3) provide training workshops for junior ..
  20. Sun Valley Workshop on Skeletal Biology
    David B Burr; Fiscal Year: 2010
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases;(2) develop a dialogue between basic and clinical investigators;(3) provide training workshops for junior ..
  21. Pathological Role of bFGF in Human Adult Articular Cartilage
    HEE JEONG IM SAMPEN; Fiscal Year: 2010
    ..Better understanding of the regulation and function of the posttranslational modifier SUMO in traumatic/arthritic cartilage may provide new targets for therapeutic intervention in cartilage-associated joint diseases such as OA.
  22. Advanced MR Imaging of Early Osteoarthritis
    Garry E Gold; Fiscal Year: 2013
    ..musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient- oriented research (POR) career...
  23. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases; (2) develop a dialogue between basic and clinical investigators; (3) provide training workshops for junior ..
  24. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2007
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases; (2) develop a dialogue between basic and clinical investigators; (3) provide training workshops for junior ..
  25. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2009
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases;(2) develop a dialogue between basic and clinical investigators;(3) provide training workshops for junior ..
  26. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2005
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases; (2) develop a dialogue between basic and clinical investigators; (3) provide training workshops for junior ..
  27. OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASES
    ANDREAS HIELSCHER; Fiscal Year: 2007
    ..develop an optical tomographic imaging modality to assist in the diagnosis, chracterization, and monitoring of joint diseases. Towards that goal we have successfully implemented and tested image reconstruction schemes and ..
  28. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
    ..tissue and biomechanical processes related to the pathogenesis, prevention and treatment of bone and joint diseases; (2) develop a dialogue between basic and clinical investigators; (3) provide training workshops for junior ..
  29. Development and Evaluation of a VRX CT Scanner
    Frank DiBianca; Fiscal Year: 2006
    ..in cancer of the head, chest, abdomen, and extremities, as well as in atherosclerosis, arthritis and other joint diseases, bone fractures, abdominal calculi, and many other diseases...
  30. Hybrid Composite Scaffolds for Cartilage Tissue Engineering
    GEOFFREY ERICKSON; Fiscal Year: 2009
    ..The ultimate goal of this study is to develop tissue engineering technologies that can eventually be used to treat osteoarthritis and other joint diseases.
  31. HUMAN RETROVIRUS-5 AND ARTHRITIS
    Robin Patel; Fiscal Year: 2002
    Osteoarthritis and rheumatoid arthritis are the most common joint diseases of mankind...
  32. Quantitative periprosthetic PET/CT
    Thomas Lang; Fiscal Year: 2009
    ..with artificial hips and knees has become a very successful surgical choice to treat osteoarthritis and other joint diseases. Because of the large number of patients so treated, the small fraction of implants that develop painful ..
  33. MEDICAL IGNORANCE (QQQ) COLLABORATORY K12 CURRICULUM
    Marlys Witte; Fiscal Year: 2005
    ..Salmon Comprehensive Cancer Center), genetics/genomics (Steele Memorial Children's Research Center), bone and joint diseases (Arthritis Center), neurosciences, respiratory diseases, and preventive medicine (new College of Public Health)..
  34. Membrane Proteins and Mycoplasma arthritidis
    LEIGH WASHBURN; Fiscal Year: 2006
    ..arthritidis-induced arthritis. This, in turn, will provide insight into how similar events may occur in inflammatory joint diseases of humans and other animals. [unreadable] [unreadable]
  35. Functional Tissue Engineering for Cartilage Repair
    Farshid Guilak; Fiscal Year: 2009
    Degenerative joint diseases such as osteoarthritis remain the source of significant pain and disability, affecting 20 million adults with an economic burden of over $40 billion per year to the United States...
  36. STRUCTURE/FUNCTION STUDIES OF VITAMIN D BINDING PROTEIN
    Rahul Ray; Fiscal Year: 2000
    ..by DBP-MAF) has raised the possibility that this cytokine may be involved in inflammatory joint diseases such as osteoarthritis, rheumatoid arthritis, periodontal diseases, etc...
  37. Telomerase and Chondrocyte Life-Span and Differentiation
    David Stokes; Fiscal Year: 2001
    ..This is exemplified in joint diseases such as osteoarthritis (OA) where the chondrocyte repair response appears to be finite...
  38. 2007 CARTILAGE BIOLOGY & PATHOLOGY GORDON RESEARCH CONFERENCE
    Henry Kronenberg; Fiscal Year: 2007
    ..Osteoarthritis (OA) and other degenerative joint diseases are not an inevitable fate coming with age...
  39. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2009
    ..potentially identifying novel targets for therapeutic intervention to control bone loss related to osteoporosis and other diseases with increased bone resorption such as bone metastasis and periodontal and joint diseases.
  40. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2007
    ..by applicant): [unreadable] Osteoarthritis (OA), or degenerative joint disease, is the most common form of joint diseases. It is a slowly progressing disease, and a major cause of morbidity in the population over 50, affecting more ..
  41. TRANSCRIPTION FACTOR NFATP IN CHONDROGENESIS
    Laurie Glimcher; Fiscal Year: 2004
    ..The potential use of such NFATp inhibitors in degenerative joint diseases such as osteoarthritis or inflammatory arthritis or in repair of endochondral bone defects and fractures, ..
  42. Physical Therapy, An Antiflammatory Signal on Arthritis
    Sudha Agarwal; Fiscal Year: 2004
    ..the molecular mechanisms of stress-induced anti-inflammatory responses that limit the degeneration in joint diseases and constitute the basis for rehabilitative physical therapies like CPM...
  43. COMPUTATIONAL FRAMEWORK FOR SIMULATING JOINT MECHANICS
    Benjamin Fregly; Fiscal Year: 2004
    Mechanical loading and especially dynamic loading, is believed to play a major role in degenerative joint diseases. Furthermore, motion (i.e., kinematics) and loading (i.e...
  44. ANTIINFLAMMATORY ACTION OF TSG-6
    Hans Georg Wisniewski; Fiscal Year: 2000
    ..the role of the TNF/IL-1-inducible TSG-6 protein in inflammation, especially in inflammatory and degenerative joint diseases. Earlier studies from the principal investigator's laboratory demonstrated that high levels of TSG-6 protein ..
  45. REGULATION OF IL-1BETA & IL-1 INHIBITOR GENE EXPRESSION
    WILLIAM AREND; Fiscal Year: 1992
    ..These studies have direct relevance to the pathophysiology of inflammatory joint diseases such as rheumatoid arthritis where IL 1 may play an important role in the initiation of early changes in the ..
  46. Real-Time MRI and 3D Modeling: Development and Application to Patellofemoral Pain
    GARRY GOLD; Fiscal Year: 2008
    ..The novel imaging and biomechanical modeling techniques developed in this research will be used to improve the diagnosis and treatment of a range of musculoskeletal disorders. ..
  47. A Biological Basis for Repair of the ACL
    Christopher Evans; Fiscal Year: 2009
    ..MRI, histology and immunohistochemistry will also be used to evaluate the healed ligament. These studies will advance our knowledge of the biology of the injured ACL and suggest novel, biologically-based approaches to healing. ..
  48. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
  49. Tissue engineered osteochondral patella resurfacing
    James Cook; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. ERYTHROCYTAPHERESIS TO LOWER IRON LOADING IN THALASSEMIA
    Alan Cohen; Fiscal Year: 2002
    ....
  51. MECHANISMS OF IMPLANT PARTICLE-INDUCED OSTEOCLASTOGENESI
    John Clohisy; Fiscal Year: 2002
    ..Our aims are: 1) to determine the mechanism(s) by which PMMA particles induce NF-kB activation in osteoclast precursor cells and 2) to determine the effect of blocking NF-kB activation on PMMA-induced osteoclastogenesis in vitro. ..
  52. Transfer of IL-1Ra cDNA to Osteoarthritic Knee
    Christopher Evans; Fiscal Year: 2008
    ..abstract_text> ..
  53. Why is Cardiac Risk Increased in Rheumatiod Arthritis
    Daniel Solomon; Fiscal Year: 2002
    ..ability to control for known cardiovascular risk factors, the extensive medication information allowing for us to explore key hypotheses regarding corticosteroid exposure, and the attempt to simultaneously control for disease severity ..
  54. Mechanics of non-contact ACL injuries in female athletes
    Christopher Powers; Fiscal Year: 2007
    ..abstract_text> ..
  55. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..
  56. Osteoporosis in Women with Rheumatoid Arthritis
    Daniel Solomon; Fiscal Year: 2006
    ..This epidemiologic data will inform future trials of osteoporosis treatments among patients with RA. As well, the study cohort will comprise one of the largest RA registries with an explicit plan to examine osteoporosis. ..
  57. Randomized Controlled Testing of Osteoporosis Education
    Daniel Solomon; Fiscal Year: 2006
    ..A multi-disciplinary Training Advisory Board will review the applicants progress regularly to ensure that the proposed training goals are met. ..
  58. Fibronectin Fragment-Induced Osteolysis Mediated by MMPs
    Sunil Kapila; Fiscal Year: 2009
    ..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..
  59. IMPROVING QUALITY OF LIFE OUTCOMES IN ASTHMA PATIENTS
    Carol Mancuso; Fiscal Year: 2003
    ..abstract_text> ..
  60. CCD detector
    Carol Muehleman; Fiscal Year: 2005
    ..Additionally, the optimized facility will greatly enhance the productivity of each user group as a consequence of detector efficiency. ..
  61. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..
  62. Bioengineering the Maturation, Size and Shape of Articular Cartilage Grafts
    Robert L Sah; Fiscal Year: 2010
    ..The resultant tissue grafts would be especially useful for replacement of articular cartilage for large and advanced defects. ..