cartilage diseases

Summary

Top Publications

  1. ncbi Evaluation of articular cartilage with 3D-SPGR MRI after autologous chondrocyte implantation
    Yuichi Wada
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
    J Orthop Sci 8:514-7. 2003
  2. ncbi [Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation: a review of 28 cases]
    H Robert
    C H Nord Mayenne, 229, boulevard Paul Lintier, 53100 Mayenne
    Rev Chir Orthop Reparatrice Appar Mot 93:701-9. 2007
  3. ncbi Microfracture: indications, technique, and results
    Riley J Williams
    Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA
    Instr Course Lect 56:419-28. 2007
  4. ncbi Clinical, histologic, and radiographic outcomes of distal femoral resurfacing with hypothermically stored osteoarticular allografts
    Philip A Davidson
    Tampa Bay Orthopaedic Specialists, 6500 66th Street North, Pinellas Park, Florida 33781, USA
    Am J Sports Med 35:1082-90. 2007
  5. ncbi Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
    C Zorzi
    Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
    Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
  6. ncbi Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair
    Hongmei Chen
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Station Centre ville, Montreal, QC, Canada
    J Orthop Res 27:1432-8. 2009
  7. ncbi Subchondral bone and cartilage disease: a rediscovered functional unit
    H Imhof
    Osteologie, Univ Klinik fur Radiodiagnostik, AKH Vienna, Austria
    Invest Radiol 35:581-8. 2000
  8. ncbi Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects
    R Shirazi
    Division of Applied Mechanics, Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    J Biomech 42:2458-65. 2009
  9. ncbi Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7 Canada
    Am J Sports Med 38:1845-56. 2010
  10. ncbi Cartilage repair: generations of autologous chondrocyte transplantation
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
    Eur J Radiol 57:24-31. 2006

Detail Information

Publications194 found, 100 shown here

  1. ncbi Evaluation of articular cartilage with 3D-SPGR MRI after autologous chondrocyte implantation
    Yuichi Wada
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
    J Orthop Sci 8:514-7. 2003
    ..The increased signal intensity of the reparative tissue represents maturation of implanted autologous chondrocytes. 3D-SPGR MRI is thought to be useful for evaluating reparative tissue after autologous chondrocyte implantation...
  2. ncbi [Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation: a review of 28 cases]
    H Robert
    C H Nord Mayenne, 229, boulevard Paul Lintier, 53100 Mayenne
    Rev Chir Orthop Reparatrice Appar Mot 93:701-9. 2007
    ..The protocol of this prospective study was validated by the ethics committee and all patients provided the informed consent for participation...
  3. ncbi Microfracture: indications, technique, and results
    Riley J Williams
    Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA
    Instr Course Lect 56:419-28. 2007
    ..Microfracture is a good first-line procedure because it does not prevent the application of other cartilage repair procedures that may be needed in the future...
  4. ncbi Clinical, histologic, and radiographic outcomes of distal femoral resurfacing with hypothermically stored osteoarticular allografts
    Philip A Davidson
    Tampa Bay Orthopaedic Specialists, 6500 66th Street North, Pinellas Park, Florida 33781, USA
    Am J Sports Med 35:1082-90. 2007
    ..Fresh osteoarticular allograft transplantation has a long history of clinical success. These grafts have typically been implanted less than 1 week from donor asystole...
  5. ncbi Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
    C Zorzi
    Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
    Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
    ..05). Treatment with I-ONE aided patient recovery after arthroscopic surgery, reduced the use of NSAIDs, and also had a positive long-term effect...
  6. ncbi Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair
    Hongmei Chen
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Station Centre ville, Montreal, QC, Canada
    J Orthop Res 27:1432-8. 2009
    ..Additional ongoing studies suggest these differences significantly affect long-term cartilage repair outcome...
  7. ncbi Subchondral bone and cartilage disease: a rediscovered functional unit
    H Imhof
    Osteologie, Univ Klinik fur Radiodiagnostik, AKH Vienna, Austria
    Invest Radiol 35:581-8. 2000
    ....
  8. ncbi Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects
    R Shirazi
    Division of Applied Mechanics, Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    J Biomech 42:2458-65. 2009
    ..As such, they potentially contribute to the initiation and development of post-traumatic osteoarthritis...
  9. ncbi Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7 Canada
    Am J Sports Med 38:1845-56. 2010
    ..Alternatively activated (AA) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular bone repair...
  10. ncbi Cartilage repair: generations of autologous chondrocyte transplantation
    Stefan Marlovits
    Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
    Eur J Radiol 57:24-31. 2006
    ..These biomaterials secure the cells in the defect area and enhance their proliferation and differentiation...
  11. ncbi Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice
    G Valverde-Franco
    J T N Wong Laboratories for Mineralized Tissue Research, and Centre for Bone and Periodontal Research, McGill University, 740 Avenue Dr Penfield, Montreal H3A 1A4, Quebec, Canada
    Hum Mol Genet 15:1783-92. 2006
    ..These results identify Fgfr3 signaling as a potential target for intervention in degenerative disorders of cartilage metabolism...
  12. ncbi Autologous osteochondral grafting--technique and long-term results
    Laszlo Hangody
    Orthopaedic and Trauma Department, Uzsoki Hospital, Mexikói street No 64, Budapest, Hungary
    Injury 39:S32-9. 2008
    ..This paper discusses the experimental background and over 15 years of clinical experience with autologous osteochondral mosaicplasty...
  13. ncbi Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 15:78-89. 2007
    ....
  14. ncbi Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects
    A Chevrier
    Chemical Engineering, Ecole Polytechnique, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 15:316-27. 2007
    ....
  15. ncbi Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects
    Caroline D Hoemann
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec H3C 3A7, Canada
    J Bone Joint Surg Am 87:2671-86. 2005
    ....
  16. ncbi Update on the biology of the chondrocyte and new approaches to treating cartilage diseases
    Mary B Goldring
    Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute and Harvard Medical School, Boston, MA 02115, USA
    Best Pract Res Clin Rheumatol 20:1003-25. 2006
    ....
  17. ncbi A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years
    Gunnar Knutsen
    Department of Orthopaedic Surgery, University of Tromsø, University Hospital North Norway, 9038 Tromsø, Norway
    J Bone Joint Surg Am 89:2105-12. 2007
    ..The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years...
  18. ncbi Articular cartilage defects in 1,000 knee arthroscopies
    Karin Hjelle
    Department of Orthopaedics, Deaconess Hospital, Haraldsplass, University of Bergen, Norway
    Arthroscopy 18:730-4. 2002
    ....
  19. ncbi Injectable mesenchymal stem cell therapy for large cartilage defects--a porcine model
    Kevin B L Lee
    Department of Orthopaedic Surgery, National University of Singapore, Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    Stem Cells 25:2964-71. 2007
    ..The use of intra-articular injections of mesenchymal stem cells suspended in HA is a viable option for treating large cartilage defects. This would be further explored in clinical trials...
  20. ncbi Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes
    Alberto Gobbi
    Orthopaedic Arthroscopic Surgery International, Via Amadeo 24, 20133 Milan, Italy
    Knee Surg Sports Traumatol Arthrosc 13:213-21. 2005
    ..However because of the decline in sports participation over time, microfracture may not be the definitive procedure for the athlete's knee and other procedures may be indicated in the future...
  21. pmc Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy
    Sander M Botter
    Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Age (Dordr) 33:247-60. 2011
    ..These findings underline the exceptional segmental nature of progeroid conditions and provide an explanation for pro- and anti-aging features occurring in the same individual...
  22. ncbi Current surgical options for articular cartilage repair
    G M Peretti
    University of Milan, Milan, Italy
    Acta Neurochir Suppl 108:213-9. 2011
    ..Today, however, due to the lack of comparative studies, it is not always possible to define the best treatment choice for the different cartilage pathologies...
  23. ncbi Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage
    T Virén
    Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
    J Med Eng Technol 36:185-92. 2012
    ..Since the techniques were found to be complementary to each other, dual modality imaging techniques could provide a useful tool for the arthroscopic evaluation of the integrity of articular cartilage...
  24. ncbi Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses
    N C R te Moller
    Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, Utrecht 3508 TD, The Netherlands Electronic address
    Vet J 197:589-95. 2013
    ..OCT could therefore improve the diagnostic value of arthroscopy in equine orthopaedic surgery...
  25. ncbi Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years
    Elizaveta Kon
    Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 37:33-41. 2009
    ..Various approaches have been proposed to treat articular cartilage lesions, which are plagued by inherent limited healing potential...
  26. ncbi Temporal and spatial modulation of chondrogenic foci in subchondral microdrill holes by chitosan-glycerol phosphate/blood implants
    A Chevrier
    Department of Chemical Engineering, Ecole Polytechnique de Montreal, PO Box 6079, Succ Centre Ville, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 19:136-44. 2011
    ..The purpose of this study was to structurally characterize these sites of chondrogenesis and to investigate the effects of chitosan-glycerol phosphate (GP)/blood implants on their formation...
  27. ncbi Screening of knee-joint vibroarthrographic signals using statistical parameters and radial basis functions
    Rangaraj M Rangayyan
    Department of Electrical and Computer Engineering Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
    Med Biol Eng Comput 46:223-32. 2008
    ..With a database of 89 VAG signals, screening efficiency of up to 0.82 was achieved, in terms of the area under the receiver operating characteristics curve, using a neural network classifier based on radial basis functions...
  28. ncbi A cell-free collagen type I device for the treatment of focal cartilage defects
    Karsten Gavenis
    Department of Orthopaedic Surger, Aachen University Hospital, Aachen, Germany
    Artif Organs 34:79-83. 2010
    ..The arthroscopic transplantation of a collagen gel plug may be one option in the treatment of focal cartilage defects...
  29. ncbi The manangement of knee cartilage defects with modified amic technique: preliminary results
    A Schiavone Panni
    University of Molise, Department of Science for Health, Italy
    Int J Immunopathol Pharmacol 24:149-52. 2011
    ..It is safe and reliable. Our data are in accordance with previously reported series in literature and confirm the good objective and subjective results of this procedure...
  30. ncbi Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders
    Eva Grimaud
    Laboratoire de Physiopathologie de la Résorption Osseuse EE 99 01, Faculte de Medecine, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France
    Cytokine Growth Factor Rev 13:241-57. 2002
    ..In vivo induction of the expression of TGF-beta and the use of gene transfer may provide a new approach for treatment of osteoarthritic lesions...
  31. ncbi Arthroscopic implantation of a matrix to cover large chondral defect during microfracture
    Thore Zantop
    Department of Trauma, Hand and Reconstructive Surgery, University of Munster, Germany
    Arthroscopy 25:1354-60. 2009
    ..We conclude that the introduced technique may be helpful in large cartilage defects combining the benefit of microfracturing and avoidance of the increased morbidity of matrix-associated autologous chondrocyte implantation...
  32. pmc Autologous platelet gel for tissue regeneration in degenerative disorders of the knee
    Marcello Napolitano
    Immunohaematology and Transfusion Medicine Unit, Cosenza Hospital, Cosenza, Italy
    Blood Transfus 10:72-7. 2012
    ..The refinement of the use of platelet-derived growth factors that has occurred over the last decade has led to a broadening of the fields of use, in particular for new treatments in orthopaedics aimed at improving tissue regeneration...
  33. ncbi Mesenchymal stem cell-based therapy for cartilage repair: a review
    Hideyuki Koga
    Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, PO Box 4014, Ullevaal Stadion, 0806 Oslo, Norway
    Knee Surg Sports Traumatol Arthrosc 17:1289-97. 2009
    ..Therefore, it is difficult to make conclusions in human studies. This requires randomized clinical trials to evaluate the effectiveness of MSC-based cell therapy for cartilage repair...
  34. ncbi Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)--5-year follow-up
    Peter Behrens
    Department of Orthopaedics, University Clinic of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Knee 13:194-202. 2006
    ..The significantly improved results on three scores after 5 years suggest that MACT represents a suitable but cost-intensive alternative in the treatment of local cartilage defects in the knee...
  35. ncbi Magnetic resonance imaging of cartilage repair
    Hollis G Potter
    Magnetic Resonance Imaging, Hospital for Special Surgery, Weil Medical Collegeof Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Sports Med Arthrosc 16:236-45. 2008
    ....
  36. pmc Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Res Ther 10:R84. 2008
    ..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
  37. ncbi Gene delivery to cartilage defects using coagulated bone marrow aspirate
    A Pascher
    Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Gene Ther 11:133-41. 2004
    ....
  38. ncbi [Imaging of cartilage]
    C Glaser
    Institut fur Klinische Radiologie, Klinikum Grosshadern der Ludwig Maximilians Universität München
    Radiologe 46:16-25. 2006
    ..The presence of two or more findings increases diagnostic accuracy. Prognosis is associated with the size of the affected area...
  39. ncbi [Evaluation of cartilage defects in the knee: validity of clinical, magnetic-resonance-imaging and radiological findings compared with arthroscopy]
    G Spahn
    Praxisklinik für Unfallchirurgie und Orthopädie, Sophienstrasse 16, 99817, Eisenach, Germany
    Unfallchirurg 110:414-24. 2007
    ..The study was aimed to evaluate the validity of clinical, radiological and MRI examination for cartilage defects of the knee compared with arthroscopic finding...
  40. ncbi The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint
    Christoph Erggelet
    Department for Orthopaedic Surgery and Traumatology, University of Freiburg, Freiburg, Germany
    Arthroscopy 19:108-10. 2003
    ..Tibial defects can be addressed. The arthroscopic technique for the implantation of autologous chondrocytes eliminates a substantial amount of the side effects known to occur after open autologous chondrocyte implantation procedures...
  41. ncbi The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study
    Kai Mithoefer
    Institute for Cartilage Repair, The Hospital for Special Surgery, 525 East 70th Street, New York, NY 10021, USA
    J Bone Joint Surg Am 87:1911-20. 2005
    ..The purpose of our study was to identify the factors that affect the clinical outcome from this cartilage repair technique...
  42. ncbi Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration
    Jennifer J Wood
    Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Bone Joint Surg Am 88:503-7. 2006
    ..The present report describes the adverse events following Carticel implantation as reported to the Food and Drug Administration from 1996 to 2003...
  43. ncbi [Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)]
    P Behrens
    Orthopädische Universität der RWTH Aachen, Aachen
    Z Orthop Ihre Grenzgeb 142:529-39. 2004
    ....
  44. ncbi Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up
    L J Micheli
    Division of Sports Medicine, Department of Orthopaedic Surgery, Children's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin J Sport Med 11:223-8. 2001
    ..CONCLUSIONS: These results of this study indicate excellent graft survivorship using ACI as well as substantial improvement in functional outcome...
  45. pmc Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results
    Christian Ossendorf
    Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arthritis Res Ther 9:R41. 2007
    ..The results suggest that implanting BioSeed-C is an effective treatment option for the regeneration of posttraumatic and/or osteoarthritic defects of the knee...
  46. ncbi Scaffold-based articular cartilage repair
    Ramille M Capito
    Department of Material Science and Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    IEEE Eng Med Biol Mag 22:42-50. 2003
  47. ncbi Treatment of deep cartilage defects of the knee using autologous chondrograft transplantation and by abrasive techniques--a randomized controlled study
    P Visna
    Department of Surgery, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
    Acta Chir Belg 104:709-14. 2004
    ..To compare outcomes of surgical treatment of deep cartilage defects of the knee in a group of patients treated by autologous chondrograft transplantation versus patients treated by abrasive techniques...
  48. ncbi Knee chondral lesions: incidence and correlation between arthroscopic and magnetic resonance findings
    David Figueroa
    Orthopaedic Surgery Unit Clínica Alemana de Santiago and Faculty of Medicine, Universidad del Desarrollo, Santiago, Chile
    Arthroscopy 23:312-5. 2007
    ..To determine the incidence and morphologic characteristics of knee chondral lesions found at arthroscopy and their correlation with magnetic resonance imaging (MRI)...
  49. pmc Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography
    Ashley W Palmer
    George W Woodruff School of Mechanical Engineering and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 103:19255-60. 2006
    ..Equilibrium partitioning of an ionic contrast agent via microcomputed tomography thus provides a powerful approach to quantitatively assess 3D cartilage composition and morphology for studies of cartilage degradation and repair...
  50. ncbi Evaluation of grades 3 and 4 chondromalacia of the knee using T2*-weighted 3D gradient-echo articular cartilage imaging
    B J Murphy
    Department of Radiology, The University of Miami School of Medicine, The Joseph Applebaum MRI Center, FL 33136, USA
    Skeletal Radiol 30:305-11. 2001
    ..CONCLUSION: The results demonstrate that T2*-weighted 3D gradient-echo articular cartilage imaging can identify grades 3 and 4 chondromalacia of the knee...
  51. ncbi Histological evaluation of a mosaicplasty of the femoral condyle-retrieval specimens obtained after total knee arthroplasty--a case report
    Niels Kock
    Department of Orthopaedics, Rijnstate Hospital, Postbus 9555, Arnhem, Nijmegen, The Netherlands
    Acta Orthop Scand 75:505-8. 2004
  52. ncbi Evaluation of cartilage injuries and repair
    Mats Brittberg
    Department of Orthopaedics, Goteborg University, Kungsbacka Hospital, Sweden
    J Bone Joint Surg Am 85:58-69. 2003
  53. ncbi [First results of a prospective randomized clinical trial on traditional chondrocyte transplantation vs CaReS-Technology]
    U Schneider
    Z Orthop Ihre Grenzgeb 141:496-7. 2003
  54. ncbi Osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee: results at 5 to 9 years
    Eirik Solheim
    Deaconess University Hospital, Haraldsplass, NO 5009, Bergen, Norway
    Knee 17:84-7. 2010
    ..In conclusion, the mosaicplasty leads to improvement of symptoms and function at short- and medium-term follow-up. A deterioration of the results is observed from 12 months postoperatively to 5-9 years postoperatively...
  55. pmc Poor accuracy and interobserver reliability of knee arthroscopy measurements are improved by the use of variable angle elongated probes
    S P Oakley
    Department of Rheumatology, St George Hospital, University of New South Wales, Sydney, Australia
    Ann Rheum Dis 61:540-3. 2002
    ....
  56. pmc Near-infrared (NIR) spectroscopy. A new method for arthroscopic evaluation of low grade degenerated cartilage lesions. Results of a pilot study
    Gunter Spahn
    Center of Traumatology and Orthopaedic Surgery, Eisenach, Germany
    BMC Musculoskelet Disord 8:47. 2007
    ..Objective measurements are required. A novel NIRS (near-infrared-spectroscopy) device for detection of low-grade cartilage defects was evaluated in a preliminary clinical study...
  57. ncbi Correlation of cartilage stiffness to thickness and level of degeneration using a handheld indentation probe
    Gabriele G Niederauer
    OsteoBiologics, Inc, San Antonio, TX 78249 3308, USA
    Ann Biomed Eng 32:352-9. 2004
    ..This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints...
  58. ncbi Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
    Chisa Hidaka
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
    J Orthop Res 21:573-83. 2003
    ..In this context we hypothesized that implantation of genetically modified chondrocytes expressing BMP-7 would accelerate the formation of hyaline-like repair tissue in an equine model of cartilage defect repair...
  59. ncbi Arthroscopic evaluation of cartilage degeneration using indentation testing--influence of indenter geometry
    L P Li
    Faculty of Kinesiology, University of Calgary, Alta, Canada
    Clin Biomech (Bristol, Avon) 21:420-6. 2006
    ..Therefore, it is important to consider the collagen network as a distinct constituent in the study of arthroscopic evaluation of cartilage degeneration...
  60. ncbi Type II collagen mutations in rare and common cartilage diseases
    M Vikkula
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Ann Med 26:107-14. 1994
    b>Cartilage diseases include a wide variety of clinical phenotypes from common osteoarthrosis to several different types of chondrodysplasias, i.e. 'disorders of cartilage', of which more than 100 different have been described...
  61. ncbi Meniscal tear and increased tibial plateau bone area in healthy post-menopausal women
    M L Davies-Tuck
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Osteoarthritis Cartilage 16:268-71. 2008
    ....
  62. ncbi Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells
    Fei Chang
    Department of Orthopaedic Surgery, Institute of Clinical Medicine, Graduate School of Human Comprehensive Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Orthop Res 26:18-26. 2008
    ..The transplantation of autologous uncultured bone marrow-derived mononuclear cells contributes to articular cartilage repair. The easy and safe method used in this study is potentially viable for clinical application...
  63. ncbi Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. Surgical technique
    Kai Mithoefer
    Harvard Vanguard Orthopaedics and Sports Medicine, Brigham and Women s Hospital, 291 Independence Drive, Chestnut Hill, MA 02467, USA
    J Bone Joint Surg Am 88:294-304. 2006
    ..The purpose of our study was to identify the factors that affect the clinical outcome from this cartilage repair technique...
  64. ncbi Patellar cartilage lesions: comparison of magnetic resonance imaging and T2 relaxation-time mapping
    I Hannila
    Department of Diagnostic Radiology, University Hospital of Oulu, Oulu, Finland
    Acta Radiol 48:444-8. 2007
    ..To evaluate the detection and the size of focal patellar cartilage lesions in T2 mapping as compared to standard clinical magnetic resonance imaging (MRI) at 1.5T...
  65. ncbi Cartilaginous defects of the femorotibial joint: accuracy of coronal short inversion time inversion-recovery MR sequence
    Karl Peter Jungius
    Department of Radiology, University Hospital Balgrist, Forchstrasse 340, Ch 8008 Zurich, Switzerland
    Radiology 240:482-8. 2006
    ....
  66. pmc Treatment of focal articular cartilage defects in the knee: a systematic review
    Robert A Magnussen
    Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
    Clin Orthop Relat Res 466:952-62. 2008
    ..A large prospective trial investigating these techniques with the addition of a control group would be the best way to definitively address the clinical questions...
  67. ncbi Evaluation of the articular cartilage of the knee joint with vastly undersampled isotropic projection reconstruction steady-state free precession imaging
    Richard Kijowski
    Department of Radiology, University of Wisconsin Hospital, Madison, Wisconsin, USA
    J Magn Reson Imaging 24:168-75. 2006
    ..To determine the feasibility of the vastly undersampled isotropic projection reconstruction steady-state free precession (VIPR-SSFP) sequence for evaluating the articular cartilage of the knee joint...
  68. ncbi Chondrolysis after partial lateral meniscectomy in athletes
    Pier Paolo Mariani
    University of Motor Science, Rome, Italy
    Knee Surg Sports Traumatol Arthrosc 16:574-80. 2008
    ..Open surgery addressing the insufficiency of lateral or posterolateral corner has been found to be effective in improving knee function and resolve patients symptoms at a short-term follow-up...
  69. ncbi The arthroscopy-histological criterion link in endoscopic "repair" treatment of chondral and chondralbone lesions of the knee
    D Niculescu
    Department of Orthopedic Surgery, University of Medicine and Pharmacy of Craiova, Romania
    Rom J Morphol Embryol 48:415-8. 2007
    ..These histological criteria are very important estimation factors of long term results of these "repair" techniques, the microstructure showing the real biological status of these specific tissues...
  70. ncbi The treatment of articular cartilage defects using the microfracture technique
    Thomas J Gill
    Harvard Medical School, Boston, MA, USA
    J Orthop Sports Phys Ther 36:728-38. 2006
    ..The postoperative protocol used after the procedure may be as important as the surgery itself. Understanding the science behind the microfracture procedure will lead to better surgical technique and improved outcomes...
  71. ncbi [Stage oriented surgical cartilage therapy. Current situation]
    S Braun
    Berufsgenossenschaftliche Unfallklinik Murnau, Prof Küntscher Str 8, 82418, Murnau am Staffelsee
    Orthopade 36:589-99; quiz 600. 2007
    ..In order to select an adequate therapy, the classification of chondral or osteochondral lesion is needed. From a multiplicity of classification systems, those of the ICRS are of particular clinical relevance...
  72. ncbi Technical aspects of osteochondral autograft transplantation
    Anthony Miniaci
    Cleveland Clinic Sports Health, Cleveland Clinic, Cleveland, Ohio, USA
    Instr Course Lect 56:447-55. 2007
    ..Basic science research enables the continued refinement of surgical techniques and directs future advances in treatment augmentation...
  73. ncbi Autologous chondrocyte implantation: prospective MRI evaluation with clinical correlation
    F Caumo
    Istituto di Radiologia, Universita di Verona, I 37134 Verona, Italy
    Radiol Med 112:722-31. 2007
    ..This study was done to assess the progression of cartilage repair after autologous chondrocyte implantation (ACI) with magnetic resonance imaging (MRI) and to correlate the findings with the clinical outcome...
  74. ncbi [Biomaterials and cell therapy in cartilage disorders]
    Daniel Herbage
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS UCB Lyon I, IFR 128 Biosciences Lyon Gerland, 7 passage du Vercors, 69367 Lyon
    Bull Acad Natl Med 190:1399-1408; discussion 1408-9, 1475-7. 2006
    ..Tissue engineering as a treatment for osteoarthritis is even more challenging. Transplantation of genetically modified cells is an interesting concept, based on the production of therapeutic proteins directly at the target site...
  75. ncbi [Surgical treatment options for weight bearing articular surface defect]
    Laszlo Hangody
    Fovárosi Onkormányzat Uzsoki Kórháza, Ortopéd traumatológiai Osztály, Budapest
    Orv Hetil 147:2203-12. 2006
    ..This paper gives an outline of actual clinical resurfacing options and summarizes recent advances of cartilage repair...
  76. ncbi Meniscal allograft transplantation: long-term clinical results with radiological and magnetic resonance imaging correlations
    Peter C M Verdonk
    Department of Orthopaedic Surgery, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium
    Knee Surg Sports Traumatol Arthrosc 14:694-706. 2006
    ..Level of evidence is therapeutic study, Level IV and retrospective analysis of prospectively collected data...
  77. ncbi MRI of the knee at 7.0 Tesla
    O Kraff
    Erwin L Hahn Institute for Magnetic Resonance Imaging, Universitat Duisburg Essen, Essen
    Rofo 179:1231-5. 2007
    ..The goal of our study was to investigate and optimize various sequences for 7 T imaging of the knee...
  78. ncbi [Analysis of articular cartilage lesions in 5114 knee arthroscopies]
    Wojciech Widuchowski
    Regional Ośrodek Chirurgii Kolana i Artroskopi, Wojewódzki Szpital Chirurgii Urazowej w Piekarach Slaskich
    Chir Narzadow Ruchu Ortop Pol 71:117-21. 2006
    ..8%) and grade 4B the least frequent one (0.11%). The patellar articular surface (43.3%) and the medial femoral condyle (39.6%) were the most common locations of the lesions...
  79. ncbi Can pulsed electromagnetic fields protect joint cartilage?
    Ejnar Eriksson
    Knee Surg Sports Traumatol Arthrosc 15:829. 2007
  80. ncbi Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
    X Ayral
    Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
    Osteoarthritis Cartilage 13:361-7. 2005
    ..To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage...
  81. ncbi Chondromalacia induced by patellar subluxation: morphological and morphometrical aspects in rabbits
    M M S Sant'Anna
    Laboratory of Histochemistry, Department of Histology and Embryology, Biomedical Center, Institute of Biology, University of State of Rio de Janeiro, Rio de Janeiro, Brazil
    J Cell Mol Med 6:261-70. 2002
    ..The immobilization for 2 weeks and the intermittent passive daily motion afterwards for a period of 2 weeks, was effective to cause patellar chrondomalacia in rabbits...
  82. ncbi [Treatment of defects of joint cartilage]
    A Jubel
    Klinik für Unfall, Hand und Wiederherstellungschirurgie, Klinikum der Universität zu Köln, Germany
    Dtsch Med Wochenschr 127:1904-8. 2002
  83. ncbi Magnetic resonance imaging of the infrapatellar fat pad: correlation with patellar articular cartilage abnormalities
    A C Cañizares Pérez
    Department of Medical Imaging, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    JBR-BTR 88:1-6. 2005
    ..No significant association was shown between the MRI findings of Hoffa fat pad and the patellar chondropathy...
  84. ncbi [MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture]
    G Bachmann
    Abteilung für diagnostische Radiologie, Kerckhoff Klinik Bad Nauheim
    Radiologe 44:773-82. 2004
    ..Matrix-guided autologous chondrocyte implantation (MACI) was compared with microfracture (MFX) to demonstrate the reconstitution of cartilage over a two-year period using the morphological capabilities of MRI...
  85. ncbi Rate of knee cartilage loss after partial meniscectomy
    Flavia M Cicuttini
    Department of Epidemiology and Preventive Medicine, Monash University Medical School, and Alfred Hospital, Prahran, Victoria, Australia
    J Rheumatol 29:1954-6. 2002
    ..We examined whether there is a difference in cartilage loss in those who undergo a partial meniscectomy compared to healthy controls...
  86. ncbi [Articular cartilage repair with cell transplantation]
    Takahiro Okabe
    Department of Orthopaedic Surgery, Shinshu University, School of Medicine
    Clin Calcium 14:96-101. 2004
    ..This review summarized the present status of the treatment of articular cartilage injuries by cell transplantations...
  87. ncbi [Treatment of joint surface pathology by Pridie drilling]
    Rimtautas Gudas
    Kauno medicinos universiteto Ortopedijos ir traumatologijos klinika Eiveniu 2, 3007 Kaunas
    Medicina (Kaunas) 38:720-9. 2002
    ..05). At an average 23.6 months follow-up x-rays showed initial osteoarthritis signs in the knees. Consequently, we recommend Pridie tunelisation procedure until final indications of cartilage grafting techniques will be established...
  88. ncbi MR imaging of cartilage repair procedures
    Michael Recht
    Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, A21, Cleveland, OH 44195, USA
    Skeletal Radiol 32:185-200. 2003
    ....
  89. ncbi Lateral retinacular release: a survey of the International Patellofemoral Study Group
    Donald C Fithian
    Southern California Permanente Medical Group, El Cajon, California, USA
    Arthroscopy 20:463-8. 2004
    ..The purpose of this investigation was to determine current views regarding lateral release among experienced knee surgeons with a specific interest in the patellofemoral joint...
  90. ncbi Reoperation after autologous chondrocyte implantation. Indications and findings
    I Henderson
    Orthopaedic Research Department, St Vincent s and Mercy Private Hospital, East Melbourne, Victoria, Australia
    J Bone Joint Surg Br 86:205-11. 2004
    ..Troublesome mechanical symptoms required surgery in 13% of ACI-treated patients and were attributed to periosteal extrusion. Simple arthroscopic debridement was curative...
  91. ncbi [Tissue engineering: new treatment of cartilage alterations in degenerative joint diseases in horses--preliminary results of a long term study]
    D Barnewitz
    Forschungszentrum für Medizintechnik und Biotechnologie e V FZMB, Bad Langensalza
    Berl Munch Tierarztl Wochenschr 116:157-61. 2003
    ..Biochemical analysis of typical cartilage matrix molecules revealed formation of hyaline-like cartilage within tissue engineered autologous chondrocyte transplants...
  92. ncbi Operative treatment of osteochondral lesions of the talar dome: current concepts review
    Sandro Giannini
    University of Bologna, Istituti Ortopedici Rizzoli, Via G C Pupilli, 1, Bologna 40136, Italy
    Foot Ankle Int 25:168-75. 2004
    ..In this review, the aforementioned methods of operative treatment are examined and issues that are related to these methods are discussed...
  93. ncbi Patellofemoral relationships and cartilage breakdown
    A Harilainen
    Invalid Foundation, ORTON Orthopaedic Hospital, Tenholantie 10, 00280 Helsinki, Finland
    Knee Surg Sports Traumatol Arthrosc 13:142-4. 2005
    ..001). In conclusion, our results suggest that specific malalignments predispose to patellofemoral cartilage lesion, but prospective studies are needed to confirm the finding...
  94. ncbi MR in the study of knee cartilage pathologies: influence of location and grade on the effectiveness of the method
    Luca Macarini
    DIMIMP, Sezione di Diagnostica per Immagini, Universita degli Studi, Policlinico di Bari, Bari, Italy
    Radiol Med 105:296-307. 2003
    ..To evaluate the diagnostic effectiveness of magnetic resonance (MR) in knee cartilage pathologies of different regions and grades with the aim of establishing the role of MR in treatment choice...
  95. ncbi Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats
    A I Vasara
    Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland
    Calcif Tissue Int 74:107-14. 2004
    ..The goat model used here proved not to be an optimal model for ACT. The changes in subchondral bone may alter the biomechanical properties of the subchondral plate and thus the long-term survival of the repair tissue after ACT...
  96. ncbi Articular changes in experimentally induced patellar trauma
    Ioannis K Triantafillopoulos
    Knee Surg Sports Traumatol Arthrosc 10:144-53. 2002
    ....
  97. ncbi Three-point Dixon chemical-shift imaging for evaluating articular cartilage defects in the knee joint on a low-field-strength open magnet
    M A Bredella
    Department of Radiology, University of California, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
    AJR Am J Roentgenol 177:1371-5. 2001
    ..35-T open magnet. It is a sensitive and specific technique for the assessment of cartilage abnormalities in the knee...
  98. ncbi Fluorescent advanced glycation end products in the detection of factual stages of cartilage degeneration
    M Handl
    Orthopedic Clinic, Second Faculty of Medicine, Charles University in Prague, Czech Republic
    Physiol Res 56:235-42. 2007
    ..In fact, such an observation could be crucial and important for the detection of knee conditions suspected of early meniscal and/or ACL lesions especially among young patients...
  99. ncbi Subchondral bone marrow edema in patients with degeneration of the articular cartilage of the knee joint
    Richard Kijowski
    Department of Radiology, University of Wisconsin Hospital, Clinical Science Center E3 311, Madison, WI 53792 3252, USA
    Radiology 238:943-9. 2006
    ..To retrospectively determine at magnetic resonance (MR) imaging the prevalence of subchondral bone marrow edema beneath arthroscopically proved articular cartilage defects...
  100. ncbi Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging
    Siegfried Trattnig
    Department of Radiology, University Hospital of Vienna, Medical University of Vienna, A 1090 Vienna, Austria
    Magn Reson Imaging 23:779-87. 2005
    ..Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation (MACI) by a new grading and point-scale system based on noninvasive cartilage-specific magnetic resonance imaging (MRI) protocol...
  101. ncbi Bioreactor-based engineering of osteochondral grafts: from model systems to tissue manufacturing
    David Wendt
    Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, Switzerland
    J Biosci Bioeng 100:489-94. 2005
    ..In addition, by automating and standardizing the manufacturing process in controlled closed systems, bioreactors could reduce production costs and thus facilitate broader clinical impact of engineered osteochondral grafts...

Research Grants46

  1. The role of the kimble gene in regulating craniofacial morphogenesis
    Daniel S Levic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chondrocyte cell death is a central component of many degenerative cartilage diseases, such as osteoarthritis and temporomandibular joint disorders, and thus has a substantial public health impact...
  2. The use of genetic models to define the role of beta-catenin in post-natal growth
    REGIS J O'KEEFE; Fiscal Year: 2011
    ..The proposed studies will provide critical new insights regarding cartilage diseases including chondrodysplasia, bone repair, and osteoarthritis.
  3. WNT/BETA-CATENIN SIGNALING IN ENDOCHONDRAL OSSIFICATION
    Motomi Enomoto Iwamoto; Fiscal Year: 2009
    ..or acquired conditions can lead to defects in body structures, growth retardation and degenerative cartilage diseases. This project will provide novel information on mechanisms regulating behavior and function of cartilage ..
  4. Transcriptional regulation of Sox9 in chondrogenesis
    TIMOTHY JOSEPH MEAD; Fiscal Year: 2012
    ..targets, which may have clinical implications for the treatment of skeletal dysplasias and degenerative cartilage diseases such as osteoarthritis...
  5. 2013 Cartilage Biology and Pathology: Formation, Structure, Function, and Regener
    Rocky S Tuan; Fiscal Year: 2013
    ..where we stand today with respect to understanding the basic mechanisms and therapeutic potentials of cartilage diseases, and what developments are in the pipeline...
  6. Engineering Lubrication in Tissue Engineered Cartilage
    AKEPATI HARI REDDI; Fiscal Year: 2013
    ..Both of these functions are compromised in cartilage diseases and injuries such as osteoarthritis (OA)...
  7. Controlling mechanical signal transduction to treat osteoarthritis
    WOLFGANG B LIEDTKE; Fiscal Year: 2013
    ..of small molecule agonists and antagonists of TRPV4 has important implications in the treatment of cartilage diseases such as osteoarthritis...
  8. Gene Transfer Treatment of Articular Cartilage Damage
    Stephen B Trippel; Fiscal Year: 2013
    ..cell-based therapies and provide a key step in the translation of these therapies to human articular cartilage diseases. PUBLIC HEALTH RELEVANCE: Articular cartilage damage is the cause of pain and disability from acute joint ..
  9. CONTROL OF CHONDROCYTE DIFFERENTIATION
    Benoit de Crombrugghe; Fiscal Year: 2010
    ..These experiments should greatly enhance our understanding of the mechanisms whereby Sox9 controls chondrocyte differentiation and may suggest new therapeutic approaches for cartilage diseases.
  10. FUNCTION AND REGULATION OF AP-2 IN SKELETAL DEVELOPMENT
    Zhengmin Huang; Fiscal Year: 2007
    ..on a negative regulatory mechanism underlying normal cartilage development, but also may shed light on cartilage diseases due to improper regulation of chondrogenic cell function such as osteoarthritis and birth defects...
  11. 3D Analysis of MR-imaged Articular Cartilage
    Xiangmin Zhang; Fiscal Year: 2007
    ..Following cardiovascular diseases, cartilage diseases are the second most frequent cause of illness...
  12. 2005 Biology and Pathology of Cartilage Gordon Conference
    Linda Sandell; Fiscal Year: 2005
    ..An improved understanding of the mechanisms by which cartilages are generated and the pathogenesis of cartilage diseases are a high priority in biomedical research...
  13. Conference--Cartilage Biology and Pathology
    Benoit de Crombrugghe; Fiscal Year: 2003
    ..An improved understanding of the mechanisms by which cartilages are generated and the pathogenesis of cartilage diseases are said to be a high priority in biomedical research...
  14. Cartrilage Matrix Properties by Altered Gene Expression
    Jack Lewis; Fiscal Year: 2004
    ..to study the structure/function relationships for cartilage matrix molecules, and to study the mechanisms of cartilage diseases such as osteoarthritis...
  15. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  16. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  17. High Angular Resolution Diffusion Imaging with MRI
    Lawrence Frank; Fiscal Year: 2008
    ..abstract_text> ..
  18. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    ....
  19. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  20. Real-Time MRI and 3D Modeling: Development and Application to Patellofemoral Pain
    GARRY GOLD; Fiscal Year: 2008
    ..The novel imaging and biomechanical modeling techniques developed in this research will be used to improve the diagnosis and treatment of a range of musculoskeletal disorders. ..
  21. Software for the Analysis and Visualization of High Angular Resolution DTI Data
    Lawrence Frank; Fiscal Year: 2009
    ....
  22. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  23. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  24. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  25. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  26. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  27. THE ROLE OF BCL2 PROTEINS IN CHONDROCYTE BIOLOGY
    WALTER HORTON; Fiscal Year: 2004
    ..This multifaceted experimental approach is intended to probe the basic role of Bcl-2 proteins in chondrocyte biology and to identify mechanisms that are important for cartilage maintenance and the pathogenesis of OA. ..
  28. CLINICAL RESEARCH TRAINING PROGRAM
    David Felson; Fiscal Year: 2004
    ..Fourth, we will integrate residents in training into the CREST program to develop an interest in clinical research at an early stage of training. ..
  29. THE FRAMINGHAM OSTEOARTHRITIS STUDY
    David Felson; Fiscal Year: 2005
    ....
  30. Spectroscopic identification /removal of PMMA from bone
    Nancy Pleshko; Fiscal Year: 2005
    ....
  31. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  32. (BOAMRI) Biomarkers in Osteoarthritis MRI Studies
    David Felson; Fiscal Year: 2006
    ..Use of validated biomarkers will greatly accelerate therapeutic development for this pressing public health concern. ..
  33. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. THE ROLE OF BAG-1 IN CHONDROCYTE AGING AND DISEASE
    WALTER HORTON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTES
    MARY GOLDRING; Fiscal Year: 2001
    ....
  36. Transfer of IL-1Ra cDNA to Osteoarthritic Knee
    Christopher Evans; Fiscal Year: 2008
    ..abstract_text> ..
  37. Correlation of MRI with Cartilage Mechanical Stiffness
    Martha Gray; Fiscal Year: 2006
    ..abstract_text> ..
  38. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases.
  39. Structural Correlates of Knee Pain
    David Felson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  41. A Biological Basis for Repair of the ACL
    Christopher Evans; Fiscal Year: 2009
    ..MRI, histology and immunohistochemistry will also be used to evaluate the healed ligament. These studies will advance our knowledge of the biology of the injured ACL and suggest novel, biologically-based approaches to healing. ..
  42. Knee Implant Wear Evaluation-An Integrated Approach
    Timothy Wright; Fiscal Year: 2005
    ..abstract_text> ..
  43. Early Diagnosis of Growth Disorders Uing MR Imaging
    Diego Jaramillo; Fiscal Year: 2004
    ....
  44. Epigenetic Regulation of MMP-13
    MARY GOLDRING; Fiscal Year: 2008
    ..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  45. Novel High Resolution MRI Surrogates for Arthritis tria*
    Philipp Lang; Fiscal Year: 2006
    ..abstract_text> ..