- Evaluation of articular cartilage with 3D-SPGR MRI after autologous chondrocyte implantation
Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 8677, Chiba, Japan
J Orthop Sci 8:514-7. 2003
..The increased signal intensity of the reparative tissue represents maturation of implanted autologous chondrocytes. 3D-SPGR MRI is thought to be useful for evaluating reparative tissue after autologous chondrocyte implantation...
- [Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation: a review of 28 cases]
C H Nord Mayenne, 229, boulevard Paul Lintier, 53100 Mayenne
Rev Chir Orthop Reparatrice Appar Mot 93:701-9. 2007
..The protocol of this prospective study was validated by the ethics committee and all patients provided the informed consent for participation...
- Microfracture: indications, technique, and results
Riley J Williams
Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA
Instr Course Lect 56:419-28. 2007
..Microfracture is a good first-line procedure because it does not prevent the application of other cartilage repair procedures that may be needed in the future...
- Clinical, histologic, and radiographic outcomes of distal femoral resurfacing with hypothermically stored osteoarticular allografts
Philip A Davidson
Tampa Bay Orthopaedic Specialists, 6500 66th Street North, Pinellas Park, Florida 33781, USA
Am J Sports Med 35:1082-90. 2007
..Fresh osteoarticular allograft transplantation has a long history of clinical success. These grafts have typically been implanted less than 1 week from donor asystole...
- Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
..05). Treatment with I-ONE aided patient recovery after arthroscopic surgery, reduced the use of NSAIDs, and also had a positive long-term effect...
- Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair
Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Station Centre ville, Montreal, QC, Canada
J Orthop Res 27:1432-8. 2009
..Additional ongoing studies suggest these differences significantly affect long-term cartilage repair outcome...
- Subchondral bone and cartilage disease: a rediscovered functional unit
Osteologie, Univ Klinik fur Radiodiagnostik, AKH Vienna, Austria
Invest Radiol 35:581-8. 2000
- Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects
Division of Applied Mechanics, Department of Mechanical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada
J Biomech 42:2458-65. 2009
..As such, they potentially contribute to the initiation and development of post-traumatic osteoarthritis...
- Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages
Caroline D Hoemann
Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7 Canada
Am J Sports Med 38:1845-56. 2010
..Alternatively activated (AA) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular bone repair...
- Cartilage repair: generations of autologous chondrocyte transplantation
Department of Traumatology, Center for Joint and Cartilage, Medical University of Vienna, Austria
Eur J Radiol 57:24-31. 2006
..These biomaterials secure the cells in the defect area and enhance their proliferation and differentiation...
- Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice
J T N Wong Laboratories for Mineralized Tissue Research, and Centre for Bone and Periodontal Research, McGill University, 740 Avenue Dr Penfield, Montreal H3A 1A4, Quebec, Canada
Hum Mol Genet 15:1783-92. 2006
..These results identify Fgfr3 signaling as a potential target for intervention in degenerative disorders of cartilage metabolism...
- Autologous osteochondral grafting--technique and long-term results
Orthopaedic and Trauma Department, Uzsoki Hospital, Mexikói street No 64, Budapest, Hungary
Injury 39:S32-9. 2008
..This paper discusses the experimental background and over 15 years of clinical experience with autologous osteochondral mosaicplasty...
- Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
C D Hoemann
Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
Osteoarthritis Cartilage 15:78-89. 2007
- Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects
Chemical Engineering, Ecole Polytechnique, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada
Osteoarthritis Cartilage 15:316-27. 2007
- Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects
Caroline D Hoemann
Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec H3C 3A7, Canada
J Bone Joint Surg Am 87:2671-86. 2005
- Update on the biology of the chondrocyte and new approaches to treating cartilage diseases
Mary B Goldring
Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute and Harvard Medical School, Boston, MA 02115, USA
Best Pract Res Clin Rheumatol 20:1003-25. 2006
- A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years
Department of Orthopaedic Surgery, University of Tromsø, University Hospital North Norway, 9038 Tromsø, Norway
J Bone Joint Surg Am 89:2105-12. 2007
..The objective of this randomized trial was to compare autologous chondrocyte implantation with microfracture. This paper represents an update, with presentation of the clinical results at five years...
- Articular cartilage defects in 1,000 knee arthroscopies
Department of Orthopaedics, Deaconess Hospital, Haraldsplass, University of Bergen, Norway
Arthroscopy 18:730-4. 2002
- Injectable mesenchymal stem cell therapy for large cartilage defects--a porcine model
Kevin B L Lee
Department of Orthopaedic Surgery, National University of Singapore, Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
Stem Cells 25:2964-71. 2007
..The use of intra-articular injections of mesenchymal stem cells suspended in HA is a viable option for treating large cartilage defects. This would be further explored in clinical trials...
- Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes
Orthopaedic Arthroscopic Surgery International, Via Amadeo 24, 20133 Milan, Italy
Knee Surg Sports Traumatol Arthrosc 13:213-21. 2005
..However because of the decline in sports participation over time, microfracture may not be the definitive procedure for the athlete's knee and other procedures may be indicated in the future...
- Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy
Sander M Botter
Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Age (Dordr) 33:247-60. 2011
..These findings underline the exceptional segmental nature of progeroid conditions and provide an explanation for pro- and anti-aging features occurring in the same individual...
- Current surgical options for articular cartilage repair
G M Peretti
University of Milan, Milan, Italy
Acta Neurochir Suppl 108:213-9. 2011
..Today, however, due to the lack of comparative studies, it is not always possible to define the best treatment choice for the different cartilage pathologies...
- Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage
Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
J Med Eng Technol 36:185-92. 2012
..Since the techniques were found to be complementary to each other, dual modality imaging techniques could provide a useful tool for the arthroscopic evaluation of the integrity of articular cartilage...
- Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses
N C R te Moller
Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, Utrecht 3508 TD, The Netherlands Electronic address
Vet J 197:589-95. 2013
..OCT could therefore improve the diagnostic value of arthroscopy in equine orthopaedic surgery...
- Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years
Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy
Am J Sports Med 37:33-41. 2009
..Various approaches have been proposed to treat articular cartilage lesions, which are plagued by inherent limited healing potential...
- Temporal and spatial modulation of chondrogenic foci in subchondral microdrill holes by chitosan-glycerol phosphate/blood implants
Department of Chemical Engineering, Ecole Polytechnique de Montreal, PO Box 6079, Succ Centre Ville, Montreal, Quebec, Canada
Osteoarthritis Cartilage 19:136-44. 2011
..The purpose of this study was to structurally characterize these sites of chondrogenesis and to investigate the effects of chitosan-glycerol phosphate (GP)/blood implants on their formation...
- Screening of knee-joint vibroarthrographic signals using statistical parameters and radial basis functions
Rangaraj M Rangayyan
Department of Electrical and Computer Engineering Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
Med Biol Eng Comput 46:223-32. 2008
..With a database of 89 VAG signals, screening efficiency of up to 0.82 was achieved, in terms of the area under the receiver operating characteristics curve, using a neural network classifier based on radial basis functions...
- A cell-free collagen type I device for the treatment of focal cartilage defects
Department of Orthopaedic Surger, Aachen University Hospital, Aachen, Germany
Artif Organs 34:79-83. 2010
..The arthroscopic transplantation of a collagen gel plug may be one option in the treatment of focal cartilage defects...
- The manangement of knee cartilage defects with modified amic technique: preliminary results
A Schiavone Panni
University of Molise, Department of Science for Health, Italy
Int J Immunopathol Pharmacol 24:149-52. 2011
..It is safe and reliable. Our data are in accordance with previously reported series in literature and confirm the good objective and subjective results of this procedure...
- Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders
Laboratoire de Physiopathologie de la Résorption Osseuse EE 99 01, Faculte de Medecine, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France
Cytokine Growth Factor Rev 13:241-57. 2002
..In vivo induction of the expression of TGF-beta and the use of gene transfer may provide a new approach for treatment of osteoarthritic lesions...
- Arthroscopic implantation of a matrix to cover large chondral defect during microfracture
Department of Trauma, Hand and Reconstructive Surgery, University of Munster, Germany
Arthroscopy 25:1354-60. 2009
..We conclude that the introduced technique may be helpful in large cartilage defects combining the benefit of microfracturing and avoidance of the increased morbidity of matrix-associated autologous chondrocyte implantation...
- Autologous platelet gel for tissue regeneration in degenerative disorders of the knee
Immunohaematology and Transfusion Medicine Unit, Cosenza Hospital, Cosenza, Italy
Blood Transfus 10:72-7. 2012
..The refinement of the use of platelet-derived growth factors that has occurred over the last decade has led to a broadening of the fields of use, in particular for new treatments in orthopaedics aimed at improving tissue regeneration...
- Mesenchymal stem cell-based therapy for cartilage repair: a review
Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, PO Box 4014, Ullevaal Stadion, 0806 Oslo, Norway
Knee Surg Sports Traumatol Arthrosc 17:1289-97. 2009
..Therefore, it is difficult to make conclusions in human studies. This requires randomized clinical trials to evaluate the effectiveness of MSC-based cell therapy for cartilage repair...
- Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)--5-year follow-up
Department of Orthopaedics, University Clinic of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
Knee 13:194-202. 2006
..The significantly improved results on three scores after 5 years suggest that MACT represents a suitable but cost-intensive alternative in the treatment of local cartilage defects in the knee...
- Magnetic resonance imaging of cartilage repair
Hollis G Potter
Magnetic Resonance Imaging, Hospital for Special Surgery, Weil Medical Collegeof Cornell University, 535 East 70th Street, New York, NY 10021, USA
Sports Med Arthrosc 16:236-45. 2008
- Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Arthritis Res Ther 10:R84. 2008
..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
- Gene delivery to cartilage defects using coagulated bone marrow aspirate
Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Gene Ther 11:133-41. 2004
- [Imaging of cartilage]
Institut fur Klinische Radiologie, Klinikum Grosshadern der Ludwig Maximilians Universität München
Radiologe 46:16-25. 2006
..The presence of two or more findings increases diagnostic accuracy. Prognosis is associated with the size of the affected area...
- [Evaluation of cartilage defects in the knee: validity of clinical, magnetic-resonance-imaging and radiological findings compared with arthroscopy]
Praxisklinik für Unfallchirurgie und Orthopädie, Sophienstrasse 16, 99817, Eisenach, Germany
Unfallchirurg 110:414-24. 2007
..The study was aimed to evaluate the validity of clinical, radiological and MRI examination for cartilage defects of the knee compared with arthroscopic finding...
- The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint
Department for Orthopaedic Surgery and Traumatology, University of Freiburg, Freiburg, Germany
Arthroscopy 19:108-10. 2003
..Tibial defects can be addressed. The arthroscopic technique for the implantation of autologous chondrocytes eliminates a substantial amount of the side effects known to occur after open autologous chondrocyte implantation procedures...
- The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study
Institute for Cartilage Repair, The Hospital for Special Surgery, 525 East 70th Street, New York, NY 10021, USA
J Bone Joint Surg Am 87:1911-20. 2005
..The purpose of our study was to identify the factors that affect the clinical outcome from this cartilage repair technique...
- Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration
Jennifer J Wood
Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
J Bone Joint Surg Am 88:503-7. 2006
..The present report describes the adverse events following Carticel implantation as reported to the Food and Drug Administration from 1996 to 2003...
- [Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)]
Orthopädische Universität der RWTH Aachen, Aachen
Z Orthop Ihre Grenzgeb 142:529-39. 2004
- Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up
L J Micheli
Division of Sports Medicine, Department of Orthopaedic Surgery, Children's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Clin J Sport Med 11:223-8. 2001
..CONCLUSIONS: These results of this study indicate excellent graft survivorship using ACI as well as substantial improvement in functional outcome...
- Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results
Department of Traumotology and Orthopaedic Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Arthritis Res Ther 9:R41. 2007
..The results suggest that implanting BioSeed-C is an effective treatment option for the regeneration of posttraumatic and/or osteoarthritic defects of the knee...
- Scaffold-based articular cartilage repair
Ramille M Capito
Department of Material Science and Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
IEEE Eng Med Biol Mag 22:42-50. 2003
- Treatment of deep cartilage defects of the knee using autologous chondrograft transplantation and by abrasive techniques--a randomized controlled study
Department of Surgery, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
Acta Chir Belg 104:709-14. 2004
..To compare outcomes of surgical treatment of deep cartilage defects of the knee in a group of patients treated by autologous chondrograft transplantation versus patients treated by abrasive techniques...
- Knee chondral lesions: incidence and correlation between arthroscopic and magnetic resonance findings
Orthopaedic Surgery Unit Clínica Alemana de Santiago and Faculty of Medicine, Universidad del Desarrollo, Santiago, Chile
Arthroscopy 23:312-5. 2007
..To determine the incidence and morphologic characteristics of knee chondral lesions found at arthroscopy and their correlation with magnetic resonance imaging (MRI)...
- Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography
Ashley W Palmer
George W Woodruff School of Mechanical Engineering and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Proc Natl Acad Sci U S A 103:19255-60. 2006
..Equilibrium partitioning of an ionic contrast agent via microcomputed tomography thus provides a powerful approach to quantitatively assess 3D cartilage composition and morphology for studies of cartilage degradation and repair...
- Evaluation of grades 3 and 4 chondromalacia of the knee using T2*-weighted 3D gradient-echo articular cartilage imaging
B J Murphy
Department of Radiology, The University of Miami School of Medicine, The Joseph Applebaum MRI Center, FL 33136, USA
Skeletal Radiol 30:305-11. 2001
..CONCLUSION: The results demonstrate that T2*-weighted 3D gradient-echo articular cartilage imaging can identify grades 3 and 4 chondromalacia of the knee...
- Histological evaluation of a mosaicplasty of the femoral condyle-retrieval specimens obtained after total knee arthroplasty--a case report
Department of Orthopaedics, Rijnstate Hospital, Postbus 9555, Arnhem, Nijmegen, The Netherlands
Acta Orthop Scand 75:505-8. 2004
- Evaluation of cartilage injuries and repair
Department of Orthopaedics, Goteborg University, Kungsbacka Hospital, Sweden
J Bone Joint Surg Am 85:58-69. 2003
- [First results of a prospective randomized clinical trial on traditional chondrocyte transplantation vs CaReS-Technology]
Z Orthop Ihre Grenzgeb 141:496-7. 2003
- Osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee: results at 5 to 9 years
Deaconess University Hospital, Haraldsplass, NO 5009, Bergen, Norway
Knee 17:84-7. 2010
..In conclusion, the mosaicplasty leads to improvement of symptoms and function at short- and medium-term follow-up. A deterioration of the results is observed from 12 months postoperatively to 5-9 years postoperatively...
- Poor accuracy and interobserver reliability of knee arthroscopy measurements are improved by the use of variable angle elongated probes
S P Oakley
Department of Rheumatology, St George Hospital, University of New South Wales, Sydney, Australia
Ann Rheum Dis 61:540-3. 2002
- Near-infrared (NIR) spectroscopy. A new method for arthroscopic evaluation of low grade degenerated cartilage lesions. Results of a pilot study
Center of Traumatology and Orthopaedic Surgery, Eisenach, Germany
BMC Musculoskelet Disord 8:47. 2007
..Objective measurements are required. A novel NIRS (near-infrared-spectroscopy) device for detection of low-grade cartilage defects was evaluated in a preliminary clinical study...
- Correlation of cartilage stiffness to thickness and level of degeneration using a handheld indentation probe
Gabriele G Niederauer
OsteoBiologics, Inc, San Antonio, TX 78249 3308, USA
Ann Biomed Eng 32:352-9. 2004
..This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints...
- Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
J Orthop Res 21:573-83. 2003
..In this context we hypothesized that implantation of genetically modified chondrocytes expressing BMP-7 would accelerate the formation of hyaline-like repair tissue in an equine model of cartilage defect repair...
- Arthroscopic evaluation of cartilage degeneration using indentation testing--influence of indenter geometry
L P Li
Faculty of Kinesiology, University of Calgary, Alta, Canada
Clin Biomech (Bristol, Avon) 21:420-6. 2006
..Therefore, it is important to consider the collagen network as a distinct constituent in the study of arthroscopic evaluation of cartilage degeneration...
- Type II collagen mutations in rare and common cartilage diseases
Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
Ann Med 26:107-14. 1994
b>Cartilage diseases include a wide variety of clinical phenotypes from common osteoarthrosis to several different types of chondrodysplasias, i.e. 'disorders of cartilage', of which more than 100 different have been described...
- Meniscal tear and increased tibial plateau bone area in healthy post-menopausal women
M L Davies-Tuck
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria 3004, Australia
Osteoarthritis Cartilage 16:268-71. 2008
- Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells
Department of Orthopaedic Surgery, Institute of Clinical Medicine, Graduate School of Human Comprehensive Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
J Orthop Res 26:18-26. 2008
..The transplantation of autologous uncultured bone marrow-derived mononuclear cells contributes to articular cartilage repair. The easy and safe method used in this study is potentially viable for clinical application...
- Chondral resurfacing of articular cartilage defects in the knee with the microfracture technique. Surgical technique
Harvard Vanguard Orthopaedics and Sports Medicine, Brigham and Women s Hospital, 291 Independence Drive, Chestnut Hill, MA 02467, USA
J Bone Joint Surg Am 88:294-304. 2006
..The purpose of our study was to identify the factors that affect the clinical outcome from this cartilage repair technique...
- Patellar cartilage lesions: comparison of magnetic resonance imaging and T2 relaxation-time mapping
Department of Diagnostic Radiology, University Hospital of Oulu, Oulu, Finland
Acta Radiol 48:444-8. 2007
..To evaluate the detection and the size of focal patellar cartilage lesions in T2 mapping as compared to standard clinical magnetic resonance imaging (MRI) at 1.5T...
- Cartilaginous defects of the femorotibial joint: accuracy of coronal short inversion time inversion-recovery MR sequence
Karl Peter Jungius
Department of Radiology, University Hospital Balgrist, Forchstrasse 340, Ch 8008 Zurich, Switzerland
Radiology 240:482-8. 2006
- Treatment of focal articular cartilage defects in the knee: a systematic review
Robert A Magnussen
Vanderbilt Orthopaedic Institute, 4200 Medical Center East, 1215 21st Avenue South, Suite 4200, Nashville, TN, 37232 8774, USA
Clin Orthop Relat Res 466:952-62. 2008
..A large prospective trial investigating these techniques with the addition of a control group would be the best way to definitively address the clinical questions...
- Evaluation of the articular cartilage of the knee joint with vastly undersampled isotropic projection reconstruction steady-state free precession imaging
Department of Radiology, University of Wisconsin Hospital, Madison, Wisconsin, USA
J Magn Reson Imaging 24:168-75. 2006
..To determine the feasibility of the vastly undersampled isotropic projection reconstruction steady-state free precession (VIPR-SSFP) sequence for evaluating the articular cartilage of the knee joint...
- Chondrolysis after partial lateral meniscectomy in athletes
Pier Paolo Mariani
University of Motor Science, Rome, Italy
Knee Surg Sports Traumatol Arthrosc 16:574-80. 2008
..Open surgery addressing the insufficiency of lateral or posterolateral corner has been found to be effective in improving knee function and resolve patients symptoms at a short-term follow-up...
- The arthroscopy-histological criterion link in endoscopic "repair" treatment of chondral and chondralbone lesions of the knee
Department of Orthopedic Surgery, University of Medicine and Pharmacy of Craiova, Romania
Rom J Morphol Embryol 48:415-8. 2007
..These histological criteria are very important estimation factors of long term results of these "repair" techniques, the microstructure showing the real biological status of these specific tissues...
- The treatment of articular cartilage defects using the microfracture technique
Thomas J Gill
Harvard Medical School, Boston, MA, USA
J Orthop Sports Phys Ther 36:728-38. 2006
..The postoperative protocol used after the procedure may be as important as the surgery itself. Understanding the science behind the microfracture procedure will lead to better surgical technique and improved outcomes...
- [Stage oriented surgical cartilage therapy. Current situation]
Berufsgenossenschaftliche Unfallklinik Murnau, Prof Küntscher Str 8, 82418, Murnau am Staffelsee
Orthopade 36:589-99; quiz 600. 2007
..In order to select an adequate therapy, the classification of chondral or osteochondral lesion is needed. From a multiplicity of classification systems, those of the ICRS are of particular clinical relevance...
- Technical aspects of osteochondral autograft transplantation
Cleveland Clinic Sports Health, Cleveland Clinic, Cleveland, Ohio, USA
Instr Course Lect 56:447-55. 2007
..Basic science research enables the continued refinement of surgical techniques and directs future advances in treatment augmentation...
- Autologous chondrocyte implantation: prospective MRI evaluation with clinical correlation
Istituto di Radiologia, Universita di Verona, I 37134 Verona, Italy
Radiol Med 112:722-31. 2007
..This study was done to assess the progression of cartilage repair after autologous chondrocyte implantation (ACI) with magnetic resonance imaging (MRI) and to correlate the findings with the clinical outcome...
- [Biomaterials and cell therapy in cartilage disorders]
Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS UCB Lyon I, IFR 128 Biosciences Lyon Gerland, 7 passage du Vercors, 69367 Lyon
Bull Acad Natl Med 190:1399-1408; discussion 1408-9, 1475-7. 2006
..Tissue engineering as a treatment for osteoarthritis is even more challenging. Transplantation of genetically modified cells is an interesting concept, based on the production of therapeutic proteins directly at the target site...
- [Surgical treatment options for weight bearing articular surface defect]
Fovárosi Onkormányzat Uzsoki Kórháza, Ortopéd traumatológiai Osztály, Budapest
Orv Hetil 147:2203-12. 2006
..This paper gives an outline of actual clinical resurfacing options and summarizes recent advances of cartilage repair...
- Meniscal allograft transplantation: long-term clinical results with radiological and magnetic resonance imaging correlations
Peter C M Verdonk
Department of Orthopaedic Surgery, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium
Knee Surg Sports Traumatol Arthrosc 14:694-706. 2006
..Level of evidence is therapeutic study, Level IV and retrospective analysis of prospectively collected data...
- MRI of the knee at 7.0 Tesla
Erwin L Hahn Institute for Magnetic Resonance Imaging, Universitat Duisburg Essen, Essen
Rofo 179:1231-5. 2007
..The goal of our study was to investigate and optimize various sequences for 7 T imaging of the knee...
- [Analysis of articular cartilage lesions in 5114 knee arthroscopies]
Regional Ośrodek Chirurgii Kolana i Artroskopi, Wojewódzki Szpital Chirurgii Urazowej w Piekarach Slaskich
Chir Narzadow Ruchu Ortop Pol 71:117-21. 2006
..8%) and grade 4B the least frequent one (0.11%). The patellar articular surface (43.3%) and the medial femoral condyle (39.6%) were the most common locations of the lesions...
- Can pulsed electromagnetic fields protect joint cartilage?
Knee Surg Sports Traumatol Arthrosc 15:829. 2007
- Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients
Service de Rhumatologie B, Hopital Cochin, AP HP, Universite Rene Descartes, Paris, France
Osteoarthritis Cartilage 13:361-7. 2005
..To evaluate the prevalence of synovitis in painful medial tibiofemoral knee osteoarthritis (OA) and to evaluate correlation between synovitis and the structural severity and progression of tibiofemoral cartilage damage...
- Chondromalacia induced by patellar subluxation: morphological and morphometrical aspects in rabbits
M M S Sant'Anna
Laboratory of Histochemistry, Department of Histology and Embryology, Biomedical Center, Institute of Biology, University of State of Rio de Janeiro, Rio de Janeiro, Brazil
J Cell Mol Med 6:261-70. 2002
..The immobilization for 2 weeks and the intermittent passive daily motion afterwards for a period of 2 weeks, was effective to cause patellar chrondomalacia in rabbits...
- [Treatment of defects of joint cartilage]
Klinik für Unfall, Hand und Wiederherstellungschirurgie, Klinikum der Universität zu Köln, Germany
Dtsch Med Wochenschr 127:1904-8. 2002
- Magnetic resonance imaging of the infrapatellar fat pad: correlation with patellar articular cartilage abnormalities
A C Cañizares Pérez
Department of Medical Imaging, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
JBR-BTR 88:1-6. 2005
..No significant association was shown between the MRI findings of Hoffa fat pad and the patellar chondropathy...
- [MRI in the follow-up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture]
Abteilung für diagnostische Radiologie, Kerckhoff Klinik Bad Nauheim
Radiologe 44:773-82. 2004
..Matrix-guided autologous chondrocyte implantation (MACI) was compared with microfracture (MFX) to demonstrate the reconstitution of cartilage over a two-year period using the morphological capabilities of MRI...
- Rate of knee cartilage loss after partial meniscectomy
Flavia M Cicuttini
Department of Epidemiology and Preventive Medicine, Monash University Medical School, and Alfred Hospital, Prahran, Victoria, Australia
J Rheumatol 29:1954-6. 2002
..We examined whether there is a difference in cartilage loss in those who undergo a partial meniscectomy compared to healthy controls...
- [Articular cartilage repair with cell transplantation]
Department of Orthopaedic Surgery, Shinshu University, School of Medicine
Clin Calcium 14:96-101. 2004
..This review summarized the present status of the treatment of articular cartilage injuries by cell transplantations...
- [Treatment of joint surface pathology by Pridie drilling]
Kauno medicinos universiteto Ortopedijos ir traumatologijos klinika Eiveniu 2, 3007 Kaunas
Medicina (Kaunas) 38:720-9. 2002
..05). At an average 23.6 months follow-up x-rays showed initial osteoarthritis signs in the knees. Consequently, we recommend Pridie tunelisation procedure until final indications of cartilage grafting techniques will be established...
- MR imaging of cartilage repair procedures
Department of Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, A21, Cleveland, OH 44195, USA
Skeletal Radiol 32:185-200. 2003
- Lateral retinacular release: a survey of the International Patellofemoral Study Group
Donald C Fithian
Southern California Permanente Medical Group, El Cajon, California, USA
Arthroscopy 20:463-8. 2004
..The purpose of this investigation was to determine current views regarding lateral release among experienced knee surgeons with a specific interest in the patellofemoral joint...
- Reoperation after autologous chondrocyte implantation. Indications and findings
Orthopaedic Research Department, St Vincent s and Mercy Private Hospital, East Melbourne, Victoria, Australia
J Bone Joint Surg Br 86:205-11. 2004
..Troublesome mechanical symptoms required surgery in 13% of ACI-treated patients and were attributed to periosteal extrusion. Simple arthroscopic debridement was curative...
- [Tissue engineering: new treatment of cartilage alterations in degenerative joint diseases in horses--preliminary results of a long term study]
Forschungszentrum für Medizintechnik und Biotechnologie e V FZMB, Bad Langensalza
Berl Munch Tierarztl Wochenschr 116:157-61. 2003
..Biochemical analysis of typical cartilage matrix molecules revealed formation of hyaline-like cartilage within tissue engineered autologous chondrocyte transplants...
- Operative treatment of osteochondral lesions of the talar dome: current concepts review
University of Bologna, Istituti Ortopedici Rizzoli, Via G C Pupilli, 1, Bologna 40136, Italy
Foot Ankle Int 25:168-75. 2004
..In this review, the aforementioned methods of operative treatment are examined and issues that are related to these methods are discussed...
- Patellofemoral relationships and cartilage breakdown
Invalid Foundation, ORTON Orthopaedic Hospital, Tenholantie 10, 00280 Helsinki, Finland
Knee Surg Sports Traumatol Arthrosc 13:142-4. 2005
..001). In conclusion, our results suggest that specific malalignments predispose to patellofemoral cartilage lesion, but prospective studies are needed to confirm the finding...
- MR in the study of knee cartilage pathologies: influence of location and grade on the effectiveness of the method
DIMIMP, Sezione di Diagnostica per Immagini, Universita degli Studi, Policlinico di Bari, Bari, Italy
Radiol Med 105:296-307. 2003
..To evaluate the diagnostic effectiveness of magnetic resonance (MR) in knee cartilage pathologies of different regions and grades with the aim of establishing the role of MR in treatment choice...
- Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats
A I Vasara
Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland
Calcif Tissue Int 74:107-14. 2004
..The goat model used here proved not to be an optimal model for ACT. The changes in subchondral bone may alter the biomechanical properties of the subchondral plate and thus the long-term survival of the repair tissue after ACT...
- Articular changes in experimentally induced patellar trauma
Ioannis K Triantafillopoulos
Knee Surg Sports Traumatol Arthrosc 10:144-53. 2002
- Three-point Dixon chemical-shift imaging for evaluating articular cartilage defects in the knee joint on a low-field-strength open magnet
M A Bredella
Department of Radiology, University of California, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
AJR Am J Roentgenol 177:1371-5. 2001
..35-T open magnet. It is a sensitive and specific technique for the assessment of cartilage abnormalities in the knee...
- Fluorescent advanced glycation end products in the detection of factual stages of cartilage degeneration
Orthopedic Clinic, Second Faculty of Medicine, Charles University in Prague, Czech Republic
Physiol Res 56:235-42. 2007
..In fact, such an observation could be crucial and important for the detection of knee conditions suspected of early meniscal and/or ACL lesions especially among young patients...
- Subchondral bone marrow edema in patients with degeneration of the articular cartilage of the knee joint
Department of Radiology, University of Wisconsin Hospital, Clinical Science Center E3 311, Madison, WI 53792 3252, USA
Radiology 238:943-9. 2006
..To retrospectively determine at magnetic resonance (MR) imaging the prevalence of subchondral bone marrow edema beneath arthroscopically proved articular cartilage defects...
- Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging
Department of Radiology, University Hospital of Vienna, Medical University of Vienna, A 1090 Vienna, Austria
Magn Reson Imaging 23:779-87. 2005
..Monitoring of articular cartilage repair after matrix-associated autologous chondrocyte implantation (MACI) by a new grading and point-scale system based on noninvasive cartilage-specific magnetic resonance imaging (MRI) protocol...
- Bioreactor-based engineering of osteochondral grafts: from model systems to tissue manufacturing
Institute for Surgical Research and Hospital Management, University Hospital Basel, Hebelstrasse 20, Switzerland
J Biosci Bioeng 100:489-94. 2005
..In addition, by automating and standardizing the manufacturing process in controlled closed systems, bioreactors could reduce production costs and thus facilitate broader clinical impact of engineered osteochondral grafts...