spinal stenosis

Summary

Summary: Narrowing of the spinal canal.

Top Publications

  1. ncbi Measurement properties of a self-administered outcome measure in lumbar spinal stenosis
    G Stucki
    Department of Rheumatology and Physical Medicine, University Hospital, Zurich, Switzerland
    Spine (Phila Pa 1976) 21:796-803. 1996
  2. ncbi Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis
    K A Jansson
    Department of Molecular Medicine and Surgery, Section of Orthopaedics, Karolinska Institutet, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    J Bone Joint Surg Br 91:210-6. 2009
  3. ncbi Aperius PercLID stand alone interspinous system for the treatment of degenerative lumbar stenosis: experience on 152 cases
    Piervittorio Nardi
    Neurosurgical Unit, Policlinico Casilino, Rome, Italy
    J Spinal Disord Tech 23:203-7. 2010
  4. ncbi Lumbar interlaminar epidural injections in central spinal stenosis: preliminary results of a randomized, double-blind, active control trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah Paducah, KY, USA
    Pain Physician 15:51-63. 2012
  5. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010
  6. ncbi Surgery versus conservative treatment for symptomatic lumbar spinal stenosis: a systematic review of randomized controlled trials
    Francisco M Kovacs
    Departamento Cientifico, Fundacion Kovacs, Palma de Mallorca, Spain
    Spine (Phila Pa 1976) 36:E1335-51. 2011
  7. ncbi Fluoroscopic epidural injections in cervical spinal stenosis: preliminary results of a randomized, double-blind, active control trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 15:E59-70. 2012
  8. pmc Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
    James N Weinstein
    Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
    N Engl J Med 356:2257-70. 2007
  9. ncbi Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images
    Constantin Schizas
    Department of Orthopedics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Avenue Pierre Decker 4, Lausanne, Switzerland
    Spine (Phila Pa 1976) 35:1919-24. 2010
  10. ncbi Axial loading during MR imaging can influence treatment decision for symptomatic spinal stenosis
    Akio Hiwatashi
    Department of Diagnostic Radiology, Division of Diagnostic and Interventional Neuroradiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    AJNR Am J Neuroradiol 25:170-4. 2004

Research Grants

  1. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
  2. RANDOMIZED CLINICAL TRIAL: TREATMENT FOR SPINAL STENOSIS
    Anthony Delitto; Fiscal Year: 2003
  3. Diagnostic Biomarkers for Radicular Pain
    GAETANO JOHN SCUDERI; Fiscal Year: 2010
  4. MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
    Nam V Vo; Fiscal Year: 2011
  5. Low Back Pain: A Multi-Center Clinical Trial
    James N Weinstein; Fiscal Year: 2013
  6. BACK PAIN OUTCOME ASSESSMENT TEAM
    Richard Deyo; Fiscal Year: 1991
  7. Spinal Fusion Using Adipose Derived Adult Stem Cells
    Jeffrey Gimble; Fiscal Year: 2005
  8. Magnetic Resonance Imaging Near Metallic Implants
    BRIAN ANDREW HARGREAVES; Fiscal Year: 2010
  9. Safety-Sensing Independence-Enhancing Wheelchair
    William Kennedy; Fiscal Year: 2004
  10. MAINE LUMBAR SPINE STUDY
    Robert Keller; Fiscal Year: 2001

Detail Information

Publications324 found, 100 shown here

  1. ncbi Measurement properties of a self-administered outcome measure in lumbar spinal stenosis
    G Stucki
    Department of Rheumatology and Physical Medicine, University Hospital, Zurich, Switzerland
    Spine (Phila Pa 1976) 21:796-803. 1996
    ..properties and validity of a newly developed patient questionnaire for the assessment of patients with lumbar spinal stenosis was tested in an ongoing prospective multicenter observational study of patients undergoing decompressive ..
  2. ncbi Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis
    K A Jansson
    Department of Molecular Medicine and Surgery, Section of Orthopaedics, Karolinska Institutet, Karolinska University Hospital, Solna, SE 171 76 Stockholm, Sweden
    J Bone Joint Surg Br 91:210-6. 2009
    ..HRQoL) outcome by using a Euroqol (EQ-5D) questionnaire in 230 patients who underwent surgery for lumbar spinal stenosis. Data were obtained from the National Swedish Registry for operations on the lumbar spine between 2001 and ..
  3. ncbi Aperius PercLID stand alone interspinous system for the treatment of degenerative lumbar stenosis: experience on 152 cases
    Piervittorio Nardi
    Neurosurgical Unit, Policlinico Casilino, Rome, Italy
    J Spinal Disord Tech 23:203-7. 2010
    ..This study is a retrospective clinical investigation of a new interspinous device implanted via a totally percutaneous technique involving 152 consecutive patients...
  4. ncbi Lumbar interlaminar epidural injections in central spinal stenosis: preliminary results of a randomized, double-blind, active control trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah Paducah, KY, USA
    Pain Physician 15:51-63. 2012
    Chronic, persistent low back and lower extremity pain is often caused by spinal stenosis. Surgery and other interventions, including epidural injections, have been used to relieve this pain...
  5. pmc Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults
    Richard A Deyo
    Department of Family Medicine, Mail Code FM, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    JAMA 303:1259-65. 2010
    In recent decades, the fastest growth in lumbar surgery occurred in older patients with spinal stenosis. Trials indicate that for selected patients, decompressive surgery offers an advantage over nonoperative treatment, but surgeons ..
  6. ncbi Surgery versus conservative treatment for symptomatic lumbar spinal stenosis: a systematic review of randomized controlled trials
    Francisco M Kovacs
    Departamento Cientifico, Fundacion Kovacs, Palma de Mallorca, Spain
    Spine (Phila Pa 1976) 36:E1335-51. 2011
    ..Systematic review...
  7. ncbi Fluoroscopic epidural injections in cervical spinal stenosis: preliminary results of a randomized, double-blind, active control trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 15:E59-70. 2012
    Cervical spinal stenosis is a common disease that results in considerable morbidity and disability...
  8. pmc Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
    James N Weinstein
    Department of Orthopaedics, Dartmouth Medical School, Lebanon, NH, USA
    N Engl J Med 356:2257-70. 2007
    Management of degenerative spondylolisthesis with spinal stenosis is controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical treatment has not been demonstrated in controlled trials.
  9. ncbi Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images
    Constantin Schizas
    Department of Orthopedics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Avenue Pierre Decker 4, Lausanne, Switzerland
    Spine (Phila Pa 1976) 35:1919-24. 2010
    ..Retrospective radiologic study on a prospective patient cohort...
  10. ncbi Axial loading during MR imaging can influence treatment decision for symptomatic spinal stenosis
    Akio Hiwatashi
    Department of Diagnostic Radiology, Division of Diagnostic and Interventional Neuroradiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    AJNR Am J Neuroradiol 25:170-4. 2004
    ..However, the clinical significance is unclear. The purpose of this study was to determine whether the narrowing of the spinal canal with axial loading during MR imaging could influence treatment decision for spinal stenosis.
  11. ncbi Dynamic stabilization in addition to decompression for lumbar spinal stenosis with degenerative spondylolisthesis
    Klaus John Schnake
    Center for Musculosceletal Surgery, Department of Orthopedic Surgery and Traumatology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Spine (Phila Pa 1976) 31:442-9. 2006
    ..Prospective clinical study...
  12. ncbi Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study
    Y Ishimoto
    Wakayama Medical University, Wakayama City, Japan
    Osteoarthritis Cartilage 20:1103-8. 2012
    The purpose of this study was to investigate the prevalence of symptomatic lumbar spinal stenosis (LSS) and to clarify the association between symptomatic LSS and physical performance using magnetic resonance imaging (MRI) in a ..
  13. ncbi Fluoroscopic caudal epidural injections with or without steroids in managing pain of lumbar spinal stenosis: one-year results of randomized, double-blind, active-controlled trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY 42003, USA
    J Spinal Disord Tech 25:226-34. 2012
    ..A randomized, double-blind, active-controlled trial...
  14. ncbi Microdecompression for lumbar spinal canal stenosis
    B K Weiner
    Department of Orthopaedic Surgery, Summa Health Systems, Akron, Ohio, USA
    Spine (Phila Pa 1976) 24:2268-72. 1999
    ..Functional outcome scores doubled, and 87% of patients reported high satisfaction rates. CONCLUSIONS: Lumbar microdecompression is a minimally invasive technique that appears to provide excellent functional outcomes...
  15. ncbi 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation
    J S Fischgrund
    William Beaumont Hospital, Department of Orthopaedic Surgery, Royal Oak, Michigan, USA
    Spine (Phila Pa 1976) 22:2807-12. 1997
    ..of transpedicular instrumented on the operative treatment of patients with degenerative spondylolisthesis and spinal stenosis. OBJECTIVES: To determine whether the addition of transpedicular instrumented improves the clinical outcome ..
  16. pmc Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?
    Rolf Sobottke
    Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur Spine J 18:1494-503. 2009
    Neurogenic intermittent claudication, caused by lumbar spinal stenosis (LSS), usually occurs after the age of 50 and is one of the most common degenerative spinal diseases in the elderly...
  17. pmc Correlation between disability and MRI findings in lumbar spinal stenosis: a prospective study of 109 patients operated on by decompression
    Freyr G Sigmundsson
    Department of Orthopedics, Clincal Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden
    Acta Orthop 82:204-10. 2011
    MRI is the modality of choice when diagnosing spinal stenosis but it also shows that stenosis is prevalent in asymptomatic subjects over 60...
  18. pmc Lumbar spinal stenosis
    Stephane Genevay
    Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland
    Best Pract Res Clin Rheumatol 24:253-65. 2010
    Lumbar spinal stenosis (LSS) is most commonly due to degenerative changes in older individuals. LSS is being more commonly diagnosed and may relate to better access to advanced imaging and to an ageing population...
  19. ncbi Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue
    Koichi Sairyo
    Spine Research Center, Department of Bioengineering and Orthopedics, University of Toledo, Toledo, OH 43606, USA
    Spine (Phila Pa 1976) 32:E340-7. 2007
    ..A histologic, biologic, and immunohistochemical assessment using human samples of the lumbar ligamentum flavum...
  20. ncbi Dynamic change of dural sac cross-sectional area in axial loaded magnetic resonance imaging correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis
    Haruo Kanno
    Department of Orthopedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    Spine (Phila Pa 1976) 37:207-13. 2012
    ..OBJECTIVE.: To examine whether the dural sac cross-sectional area (DCSA) in axial loaded magnetic resonance imaging (MRI) correlates with the severity of clinical symptoms in patients with lumbar spinal canal stenosis (LSCS)...
  21. pmc Prognostic factors in lumbar spinal stenosis surgery
    Freyr G Sigmundsson
    Department of Orthopedics, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden
    Acta Orthop 83:536-42. 2012
    A considerable number of patients who undergo surgery for spinal stenosis have residual symptoms and inferior function and health-related quality of life after surgery. There have been few studies on factors that may predict outcome...
  22. ncbi X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up
    Björn H Strömqvist
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
    Spine (Phila Pa 1976) 38:1436-42. 2013
    ..Prospective randomized controlled study...
  23. ncbi A multicenter, prospective, randomized trial evaluating the X STOP interspinous process decompression system for the treatment of neurogenic intermittent claudication: two-year follow-up results
    James F Zucherman
    St Mary s Hospital, San Francisco, California, USA
    Spine (Phila Pa 1976) 30:1351-8. 2005
    ..A randomized, controlled, prospective multicenter trial comparing the outcomes of neurogenic intermittent claudication (NIC) patients treated with the interspinous process decompression system (X STOP) with patients treated nonoperatively...
  24. ncbi Results of 2-year follow-up of a randomized, double-blind, controlled trial of fluoroscopic caudal epidural injections in central spinal stenosis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 15:371-84. 2012
    Lumbar spinal stenosis is one of the most common causes of low back pain among older adults and can cause significant disability...
  25. doi Clinical practice. Lumbar spinal stenosis
    Jeffrey N Katz
    Center for Orthopedic and Arthritis Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 358:818-25. 2008
  26. pmc Does this older adult with lower extremity pain have the clinical syndrome of lumbar spinal stenosis?
    Pradeep Suri
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, and Spaulding Rehabilitation Hospital and VA Boston Healthcare System, Boston, Massachusetts 02114, USA
    JAMA 304:2628-36. 2010
    The clinical syndrome of lumbar spinal stenosis (LSS) is a common diagnosis in older adults presenting with lower extremity pain.
  27. ncbi Long-term outcomes of surgical and nonsurgical management of lumbar spinal stenosis: 8 to 10 year results from the maine lumbar spine study
    Steven J Atlas
    General Medicine Division and the Clinical Epidemiology Unit, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 30:936-43. 2005
    ..A prospective observational cohort study...
  28. ncbi Cyclic loads do not compromise functionality of the interspinous spacer or cause damage to the spinal segment: an in vitro analysis
    Amanesh Goyal
    Engineering Center for Orthopaedic Research Excellence E CORE, Departments of Bioengineering and Orthopaedic Surgery, Colleges of Engineering and Medicine, University of Toledo, Toledo, Ohio 43606, USA
    J Long Term Eff Med Implants 18:289-302. 2008
    ..A biomechanical study to evaluate the effects of interspinous spacer under cyclic complex loading...
  29. ncbi Dynamic interspinous process stabilization: review of complications associated with the X-Stop device
    Christian Bowers
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
    Neurosurg Focus 28:E8. 2010
    ..device is designed for the treatment of patients with neurogenic intermittent claudication due to lumbar spinal stenosis. It distracts the posterior elements of adjacent vertebral bodies, unloading the intervertebral disc, ..
  30. ncbi Lumbar spinal stenosis in older adults: current understanding and future directions
    John D Markman
    Neuromedicine Pain Management Center, University of Rochester School of Medicine and Dentistry, Department of Neurosurgery, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
    Clin Geriatr Med 24:369-88, viii. 2008
    Lumbar spinal stenosis is a common cause of low back pain in the elderly. Surgical and nonsurgical treatments have been used with varying success...
  31. pmc A non-surgical approach to the management of lumbar spinal stenosis: a prospective observational cohort study
    Donald R Murphy
    Rhode Island Spine Center, Pawtucket, RI 02860, USA
    BMC Musculoskelet Disord 7:16. 2006
    ..it is widely held that non-surgical management should be the first line of approach in patients with lumbar spinal stenosis (LSS), little is known about the efficacy of non-surgical treatments for this condition...
  32. ncbi A prospective and consecutive study of surgically treated lumbar spinal stenosis. Part I: Clinical features related to radiographic findings
    B Jonsson
    Department of Orthopedics, Lund University Hospital, Sweden
    Spine (Phila Pa 1976) 22:2932-7. 1997
    A prospective study of consecutive patients undergoing surgery for central lumbar spinal stenosis.
  33. ncbi The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects : a seven-year follow-up study
    D G Borenstein
    Division of Rheumatology, George Washington University Medical Center, Washington, DC 20037, USA
    J Bone Joint Surg Am 83:1306-11. 2001
    ..individuals had radiating leg pain; four of them had had normal findings on the original scans, two had had spinal stenosis, one had had a disc protrusion, and one had had a disc extrusion...
  34. ncbi Dynamic neutralization of the lumbar spine after microsurgical decompression in acquired lumbar spinal stenosis and segmental instability
    Carola C Würgler-Hauri
    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
    Spine (Phila Pa 1976) 33:E66-72. 2008
    ..Prospective clinical study...
  35. pmc High failure rate of the interspinous distraction device (X-Stop) for the treatment of lumbar spinal stenosis caused by degenerative spondylolisthesis
    Olaf J Verhoof
    Department of Orthopaedic Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur Spine J 17:188-92. 2008
    ..alternative to conventional surgical procedures in the treatment of symptomatic degenerative lumbar spinal stenosis. However, the effectiveness of the X-Stop in symptomatic degenerative lumbar spinal stenosis caused by ..
  36. ncbi Surgical and nonsurgical management of lumbar spinal stenosis: four-year outcomes from the maine lumbar spine study
    S J Atlas
    Medical Practices Evaluation Center and the General Medicine Division, Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Spine (Phila Pa 1976) 25:556-62. 2000
    A prospective cohort study of patients with lumbar spinal stenosis recruited from the practices of orthopedic surgeons and neurosurgeons throughout Maine.
  37. ncbi The reliability of the Shuttle Walking Test, the Swiss Spinal Stenosis Questionnaire, the Oxford Spinal Stenosis Score, and the Oswestry Disability Index in the assessment of patients with lumbar spinal stenosis
    Roland K Pratt
    Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom
    Spine (Phila Pa 1976) 27:84-91. 2002
    The Shuttle Walking Test (SWT), the Swiss Spinal Stenosis (SSS) Questionnaire, the Oxford Claudication Score (OCS), and the Oswestry Disability Index (ODI) were administered to patients with lumbar spinal stenosis and neurogenic ..
  38. ncbi Seven- to 10-year outcome of decompressive surgery for degenerative lumbar spinal stenosis
    J N Katz
    Departments of Rheumatology and Immunology, Brigham and Women s Hospital, Boston, MA, USA
    Spine (Phila Pa 1976) 21:92-8. 1996
    ..OBJECTIVE: To determine the 7- to 10-year outcome of surgery for degenerative lumbar spinal stenosis. SUMMARY OF BACKGROUND DATA: There is limited information on the impact of surgery for lumbar spinal stenosis ..
  39. ncbi Spinal canal size and clinical symptoms among persons diagnosed with lumbar spinal stenosis
    Michael E Geisser
    The Spine Program, Department of Physical Medicine and Rehabilitation, University of Michigan Health System, 325 E Eisenhower Parkway, Ann Arbor, MI 48108, USA
    Clin J Pain 23:780-5. 2007
    Clinical symptoms associated with lumbar spinal stenosis (LSS) are believed to be due to neurogenic claudication caused by narrowing of the central and lateral spinal canals...
  40. ncbi Experimental spinal stenosis: relationship between degree of cauda equina compression, neuropathology, and pain
    Miho Sekiguchi
    Department of Orthopaedic Surgery, Fukushima Medical University, School of Medicine, Fukushima City, Japan
    Spine (Phila Pa 1976) 29:1105-11. 2004
    ..An analysis of pathologic changes after different degrees of cauda equina compression...
  41. pmc Spinal stenosis prevalence and association with symptoms: the Framingham Study
    Leonid Kalichman
    Boston University, MA 02118, USA
    Spine J 9:545-50. 2009
    The prevalence of lumbar spinal stenosis (LSS) in the general population and association with low back pain (LBP) remain unclear.
  42. ncbi Surgery for lumbar spinal stenosis. Attempted meta-analysis of the literature
    J A Turner
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle
    Spine (Phila Pa 1976) 17:1-8. 1992
    A meta-analysis was undertaken to determine the effects of surgery for lumbar spinal stenosis on pain and disability. Seventy-four journal articles met inclusion criteria and were independently reviewed by two readers...
  43. ncbi Fluoroscopically guided lumbar transformational epidural steroid injections in degenerative lumbar stenosis: an outcome study
    Kenneth P Botwin
    Florida Spine Institute, Clearwater, Florida 33765, USA
    Am J Phys Med Rehabil 81:898-905. 2002
    ..To identify the short- and long-term therapeutic benefit of fluoroscopically guided lumbar transforaminal epidural steroid injections in patients with radicular leg pain from degenerative lumbar stenosis...
  44. pmc Degenerative lumbar spinal stenosis: correlation with Oswestry Disability Index and MR imaging
    Mustafa Sirvanci
    Department of Radiology, Istanbul Bilim University, Buyukdere cad No 120, Esentepe Zincirlikuyu, Istanbul, Turkey
    Eur Spine J 17:679-85. 2008
    Because neither the degree of constriction of the spinal canal considered to be symptomatic for lumbar spinal stenosis nor the relationship between the clinical appearance and the degree of a radiologically verified constriction is clear,..
  45. ncbi Depression and associated factors in patients with lumbar spinal stenosis
    Sanna Sinikallio
    Department of Rehabilitation, Kuopio University Hospital, Kuopio, Finland
    Disabil Rehabil 28:415-22. 2006
    To investigate the prevalence of depression and associated factors in patients (n = 100) with lumbar spinal stenosis selected for surgical treatment.
  46. ncbi Long-term outcomes of two different decompressive techniques for lumbar spinal stenosis
    Yi Shan Fu
    Orthopaedic Department, Affiliated Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, People s Republic of China
    Spine (Phila Pa 1976) 33:514-8. 2008
    A prospective study to evaluate the outcomes of 2 different decompressive techniques for lumbar spinal stenosis.
  47. ncbi Myeloscopic study on lumbar spinal canal stenosis with special reference to intermittent claudication
    Y Ooi
    Jichi Medical School, Department of Orthopaedic Surgery, Kawachi gun, Tochigi, Japan
    Spine (Phila Pa 1976) 15:544-9. 1990
    ..In this series, it was suggested that the microcirculatory disturbance of vessels on cauda equinae might play an important role in the development of intermittent claudication...
  48. ncbi Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults
    Virginia G Briggs
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Pain Physician 13:E347-55. 2010
    ..Injection treatment is a commonly used non-surgical procedure to alleviate lower back pain in older adults. However, the effectiveness of injection treatment, particularly in older adults, has not been well documented...
  49. ncbi Lumbar spinal stenosis: syndrome, diagnostics and treatment
    Eberhard Siebert
    Department of Neuroradiology, Humboldt University, Berlin, Germany
    Nat Rev Neurol 5:392-403. 2009
    Lumbar spinal stenosis (LSS) comprises narrowing of the spinal canal with subsequent neural compression, and is frequently associated with symptoms of neurogenic claudication...
  50. pmc A diagnostic support tool for lumbar spinal stenosis: a self-administered, self-reported history questionnaire
    Shin ichi Konno
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    BMC Musculoskelet Disord 8:102. 2007
    ..The aim of the present study was to use this tool to assess the diagnostic value of the history of the patient for categorization of LSS...
  51. ncbi Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register
    Björn Knutsson
    Department of Surgical Sciences, Uppsala University, Department of Orthopaedics, Sundsvall Hospital, Sweden
    Spine (Phila Pa 1976) 38:435-41. 2013
    ..A cohort study based on the Swedish Spine Register...
  52. ncbi Matrix metalloproteinase-3 on ligamentum flavum in degenerative lumbar spondylolisthesis
    In Soo Oh
    Department of Orthopaedic Surgery, Kang Nam St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Spine (Phila Pa 1976) 34:E552-7. 2009
    ....
  53. pmc Biomechanical evaluation of the X-Stop device for surgical treatment of lumbar spinal stenosis
    Zongmiao Wan
    Bioengineering Laboratory, Department of Orthopaedics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Spinal Disord Tech 25:374-8. 2012
    ..Controlled experimental study...
  54. pmc Effectiveness of interspinous implant surgery in patients with intermittent neurogenic claudication: a systematic review and meta-analysis
    Wouter A Moojen
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Eur Spine J 20:1596-606. 2011
    ..The main objective of this review was to perform a meta-analysis of all systematic reviews, randomized clinical trials and prospective cohort series to quantify the effectiveness of IPDs and to evaluate the potential side-effects...
  55. ncbi Minimum four-year follow-up of spinal stenosis with degenerative spondylolisthesis treated with decompression and dynamic stabilization
    Stefan Schaeren
    Center for Musculoskeletal Diseases Spine, University Hospital, Basel, Switzerland
    Spine (Phila Pa 1976) 33:E636-42. 2008
    ..Prospective clinical study...
  56. ncbi The positional magnetic resonance imaging changes in the lumbar spine following insertion of a novel interspinous process distraction device
    Manal Siddiqui
    Department of Radiology, Woodend Hospital, Aberdeen, Scotland
    Spine (Phila Pa 1976) 30:2677-82. 2005
    Patients with symptomatic lumbar spinal stenosis underwent magnetic resonance imaging to study changes in the lumbar spine in various postures before and after implantation of the X STOP Interspinous Process Distraction Device (St...
  57. ncbi Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:439-44. 2012
    ..Prospective randomized trial...
  58. pmc Gait analysis does not correlate with clinical and MR imaging parameters in patients with symptomatic lumbar spinal stenosis
    Felix Zeifang
    Department of Orthopaedic Surgery, University Clinic Heidelberg, Germany
    BMC Musculoskelet Disord 9:89. 2008
    Parameters of MR imaging play a pivotal role in diagnosing lumbar spinal stenosis (LSS), and serve as an important tool in clinical decision-making...
  59. ncbi Results of surgical treatment of adult idiopathic scoliosis with low back pain and spinal stenosis: a study of long-term clinical radiographic outcomes
    Gary S Shapiro
    Hospital for Special Surgery, New York, New York 10021, USA
    Spine (Phila Pa 1976) 28:358-63. 2003
    A case series of adults with surgical treatment for adult idiopathic thoracolumbar and/or lumbar scoliosis, low back pain, and spinal stenosis was studied.
  60. pmc Clinical evaluation of the preliminary safety and effectiveness of a minimally invasive interspinous process device APERIUS(®) in degenerative lumbar spinal stenosis with symptomatic neurogenic intermittent claudication
    Jan Van Meirhaeghe
    Dienst Orthopedie en Traumatologie, AZ Sint Jan Brugge Oostende AV, Ruddershove 10, 8000 Brugge, Belgium
    Eur Spine J 21:2565-72. 2012
    ..decompressive surgery for patients with neurogenic intermittent claudication (NIC) due to degenerative lumbar spinal stenosis (DLSS). APERIUS(®) is a minimally invasive IPD that can be implanted percutaneously...
  61. ncbi Preoperative predictors for postoperative clinical outcome in lumbar spinal stenosis: systematic review
    Timo J Aalto
    Department of Surgery, Kuopio University, Kuopio, Finland
    Spine (Phila Pa 1976) 31:E648-63. 2006
    ..Systematic review...
  62. ncbi The treatment mechanism of an interspinous process implant for lumbar neurogenic intermittent claudication
    Joshua C Richards
    San Francisco Orthopaedic Residency Program, University of California, USA
    Spine (Phila Pa 1976) 30:744-9. 2005
    ..The spinal canal and neural foramina dimensions of cadaver lumbar spines were quantified during flexion and extension using magnetic resonance imaging before and after placement of an interspinous process implant...
  63. pmc Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis
    Johannes Kuchta
    Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
    Eur Spine J 18:823-9. 2009
    The clinical outcome of patients with symptomatic lumbar spinal stenosis (LSS) was assessed during a follow-up period of 2 years after X-Stop implantation...
  64. ncbi Validity and reproducibility of self-report measures of walking capacity in lumbar spinal stenosis
    Christy C Tomkins-Lane
    Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada
    Spine (Phila Pa 1976) 35:2097-102. 2010
    ..Measurement (validity) study...
  65. ncbi Evaluation of postoperative spinal epidural hematoma after microendoscopic posterior decompression for lumbar spinal stenosis: a clinical and magnetic resonance imaging study
    Ko Ikuta
    Department of Orthopedic Surgery, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    J Neurosurg Spine 5:404-9. 2006
    ..The purpose of this study was to investigate the clinical consequences of SEH after microendoscopic posterior decompression (MEPD) in patients with lumbar spinal stenosis.
  66. ncbi Indication of fusion for lumbar spinal stenosis in elderly patients and its significance
    K Yone
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Spine (Phila Pa 1976) 21:242-8. 1996
    ..OBJECTIVES: To determine the indication of decompression with fusion for lumbar spinal stenosis in elderly patients...
  67. ncbi Bilateral pedicle stress fracture in a patient with lumbar spinal stenosis: a case report
    Minoru Doita
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    J Spinal Disord Tech 21:531-4. 2008
    A case of bilateral pedicle stress fracture in a patient with lumbar spinal stenosis is reported, and the literature is reviewed.
  68. ncbi Lumbar motion segment pathology adjacent to thoracolumbar, lumbar, and lumbosacral fusions
    J D Schlegel
    Department of Orthopedic Surgery, University of Utah, School of Medicine, Salt Lake City, USA
    Spine (Phila Pa 1976) 21:970-81. 1996
    ..RESULTS. Fifty-eight patients developed spinal stenosis, disc herniation, or instability at a segment adjacent to a previously asymptomatic fusion that was done an ..
  69. ncbi The prevalence and pathogenesis of synovial cysts within the ligamentum flavum in patients with lumbar spinal stenosis and radiculopathy
    Martin J Wilby
    The Adelaide Centre for Spinal Research and Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Spine (Phila Pa 1976) 34:2518-24. 2009
    A clinicopathologic study of synovial cysts in the ligamentum flavum (LF) in patients with spinal stenosis.
  70. ncbi Bilateral decompressive surgery in lumbar spinal stenosis associated with spondylolisthesis: unilateral approach and use of a microscope and tubular retractor system
    Sylvain Palmer
    Mission Hospital Regional Medical Center, Mission Viejo, California, USA
    Neurosurg Focus 13:E4. 2002
    The objective of this study was to assess the feasibility and efficacy of treating spondylolisthesis-related spinal stenosis via unilateral approach bilateral decompression in which METRx-MD instrumentation is placed.
  71. ncbi The relationship between the cross-sectional area of the cauda equina and the preoperative symptoms in central lumbar spinal stenosis
    Osamu Ogikubo
    Department of Musculoskeletal Medicine, Nagoya City University, Graduate School of Medical Sciences 1, Nagoya City, Aichi, Japan
    Spine (Phila Pa 1976) 32:1423-8; discussion 1429. 2007
    ..A cross-sectional registry and imaging cohort study...
  72. pmc Comparative effectiveness evidence from the spine patient outcomes research trial: surgical versus nonoperative care for spinal stenosis, degenerative spondylolisthesis, and intervertebral disc herniation
    Anna N A Tosteson
    The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, NH 03756, USA
    Spine (Phila Pa 1976) 36:2061-8. 2011
    ..Cost-effectiveness analysis of a randomized plus observational cohort trial...
  73. ncbi The use of the percentage change in Oswestry Disability Index score as an outcome measure in lumbar spinal surgery
    D G Little
    Sydney Adventist Hospital, Wahroonga, NSW, Australia
    Spine (Phila Pa 1976) 19:2139-43. 1994
    ....
  74. ncbi Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review
    Standiford Helm Ii
    Pacific Coast Pain Management Center, Laguna Hills, CA, USA
    Pain Physician 15:E435-62. 2012
    Low back pain after either post lumbar surgery syndrome or spinal stenosis in the absence of surgery is a vexing problem...
  75. ncbi Surgical treatment patterns among Medicare beneficiaries newly diagnosed with lumbar spinal stenosis
    Er Chen
    Quorum Consulting, Inc, San Francisco, CA 94104, USA
    Spine J 10:588-94. 2010
    Lumbar spinal stenosis (LSS) is a prevalent degenerative condition in the elderly that can be managed medically or with surgical treatments...
  76. ncbi Smokers show less improvement than nonsmokers two years after surgery for lumbar spinal stenosis: a study of 4555 patients from the Swedish spine register
    Bengt Sandén
    Section of Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Spine (Phila Pa 1976) 36:1059-64. 2011
    ..A cohort study based on the Swedish Spine Register...
  77. ncbi Bilateral decompression of lumbar spinal stenosis involving a unilateral approach with microscope and tubular retractor system
    Sylvain Palmer
    Mission Hospital Regional Medical Center, Mission Viejo, California, USA
    J Neurosurg 97:213-7. 2002
    The authors studied a consecutive series of patients with spinal stenosis in whom surgery was performed by a single surgeon who used a microscopic tubular retractor system (METRx-MD); patients underwent prospective evaluation involving ..
  78. ncbi Minimally invasive operative management for lumbar spinal stenosis: overview of early and long-term outcomes
    Farbod Asgarzadie
    Division of Neurological Surgery, University of California Los Angeles, Santa Monica, CA 90404, USA
    Orthop Clin North Am 38:387-99; abstract vi-vii. 2007
    ..However, this traditional surgical treatment of lumbar spinal stenosis (LSS) is often associated with significant postoperative pain, disability, and dysfunction...
  79. ncbi Protocol for evaluation of the comparative effectiveness of percutaneous adhesiolysis and caudal epidural steroid injections in low back and/or lower extremity pain without post surgery syndrome or spinal stenosis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:E91-E110. 2010
    ..Percutaneous adhesiolysis has been studied in chronic pain syndromes related to post laminectomy syndrome and spinal stenosis with encouraging results...
  80. ncbi Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study
    Sanna Sinikallio
    Department of Rehabilitation, Kuopio University Hospital, Kuopio, Finland
    Spine (Phila Pa 1976) 36:677-82. 2011
    ..Prospective clinical study...
  81. pmc Surgical treatment of spinal stenosis with and without degenerative spondylolisthesis: cost-effectiveness after 2 years
    Anna N A Tosteson
    Multidisciplinary Clinical Research Center in Musculoskeletal Diseases, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Ann Intern Med 149:845-53. 2008
    ..The SPORT (Spine Patient Outcomes Research Trial) reported favorable surgery outcomes over 2 years among patients with stenosis with and without degenerative spondylolisthesis, but the economic value of these surgeries is uncertain...
  82. pmc Study protocol- Lumbar Epidural steroid injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults
    Janna L Friedly
    Comparative Effectiveness, Cost and Outcomes Research Center, University of Washington, Seattle, USA
    BMC Musculoskelet Disord 13:48. 2012
    Lumbar spinal stenosis is one of the most common causes of low back pain among older adults and can cause significant disability. Despite its prevalence, treatment of spinal stenosis symptoms remains controversial...
  83. ncbi Clinical outcome of nonoperative treatment for lumbar spinal stenosis, and predictive factors relating to prognosis, in a 5-year minimum follow-up
    Hiroshi Miyamoto
    Department of Orthopaedic Surgery, National Hospital Organization Kobe Medical Center, Kobe, Japan
    J Spinal Disord Tech 21:563-8. 2008
    A prospective long-term follow-up study of nonoperative treatment for lumbar spinal stenosis (LSS) and multivariable analysis of the prognosis.
  84. ncbi Minimally invasive lumbar spinal decompression in the elderly: outcomes of 50 patients aged 75 years and older
    David S Rosen
    Section of Neurosurgery, Department of Surgery, University of Chicago Medical Center and Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Neurosurgery 60:503-9; discussion 509-10. 2007
    Lumbar spinal stenosis and spondylosis are major causes of morbidity among the elderly...
  85. ncbi Preoperative and postoperative instability in lumbar spinal stenosis
    K E Johnsson
    Department of Orthopaedics, Malmo General Hospital, Lund University, Sweden
    Spine (Phila Pa 1976) 14:591-3. 1989
    Sixty-one patients operated on for spinal stenosis, without a fusion, were studied retrospectively. Preoperative instability, as revealed by functional myelography, was found to predict a poor prognosis (P less than 0.01)...
  86. ncbi Preganglionic approach to transforaminal epidural steroid injections
    Henry L Lew
    Physical Medicine and Rehabilitation Service, VA Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, California, USA
    Am J Phys Med Rehabil 83:378. 2004
  87. ncbi Treatment of lumbar spinal stenosis with epidural steroid injections: a retrospective outcome study
    Elva G Delport
    Christiana Spine Center, Newark, DE, USA
    Arch Phys Med Rehabil 85:479-84. 2004
    To determine patient satisfaction, relief of pain, frequency of injections, change of function, and subsequent surgical rate in patients who received epidural steroid injections (ESIs) for the diagnosis of lumbar spinal stenosis (LSS).
  88. pmc Midterm outcome after unilateral approach for bilateral decompression of lumbar spinal stenosis: 5-year prospective study
    Halit Cavusoglu
    Department of Neurosurgery, Sisli Etfal State Hospital, 34303, Istanbul, Turkey
    Eur Spine J 16:2133-42. 2007
    ..effectiveness of bilateral decompression via a unilateral approach in the treatment of degenerative lumbar spinal stenosis. We have conducted a prospective study to compare the midterm outcome of unilateral laminotomy with ..
  89. pmc Self-rated evaluation of outcome of the implantation of interspinous process distraction (X-Stop) for neurogenic claudication
    Paul Brussee
    Faculty of Medical Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Eur Spine J 17:200-3. 2008
    The treatment of lumbar spinal stenosis is either conservative or surgical decompression. Recently, an interspinous decompression device (X-Stop) has been developed as an alternative...
  90. ncbi The Cochrane review of surgery for lumbar disc prolapse and degenerative lumbar spondylosis
    J N Gibson
    University Department of Orthopaedic Surgery, Princess Margaret Rose Orthopaedic Hospital, Edinburgh, Scotland
    Spine (Phila Pa 1976) 24:1820-32. 1999
    ..A Cochrane review of randomized controlled trials...
  91. ncbi Outcome after less-invasive decompression of lumbar spinal stenosis: a randomized comparison of unilateral laminotomy, bilateral laminotomy, and laminectomy
    Claudius Thome
    Department of Neurosurgery, University Hospital Mannheim, Faculty for Clinical Medicine of the Karl Ruprecht University of Heidelberg, Mannheim, Germany
    J Neurosurg Spine 3:129-41. 2005
    ..Recently, limited decompression procedures have been proposed in the treatment of lumbar stenosis. The authors undertook a prospective study to compare the safety and outcome of unilateral and bilateral laminotomy with laminectomy...
  92. ncbi Occult spinous process fractures associated with interspinous process spacers
    David H Kim
    Tufts University School of Medicine, 125 Parker Hill Ave, Boston, MA 02120, USA
    Spine (Phila Pa 1976) 36:E1080-5. 2011
    ..Prospective observational study...
  93. ncbi Is spinal stenosis better treated surgically or nonsurgically?
    Aravind Athiviraham
    Department of Surgery, Queen s University, Kingston, Ontario, Canada
    Clin Orthop Relat Res 458:90-3. 2007
    For patients with clinical and radiographic lumbar spinal stenosis, is surgery or continued nonsurgical treatment a better option for improvements in baseline disability scores; and what proportion of patients treated surgically and ..
  94. ncbi Disability in patients with degenerative lumbar spinal stenosis
    Sang I Lin
    Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan
    Arch Phys Med Rehabil 87:1250-6. 2006
    To determine factors associated with disability in patients with degenerative lumbar spinal stenosis.
  95. ncbi Analysis of complications in patients treated with the X-Stop Interspinous Process Decompression System: proposal for a novel anatomic scoring system for patient selection and review of the literature
    Giuseppe M V Barbagallo
    Department of Neurosurgery, Azienda Ospedaliero Universitaria Policlinico G Rodolico, Catania, Italy
    Neurosurgery 65:111-19; discussion 119-20. 2009
    ..The aim of this study was to analyze a series of complications occurring at a single institution and their potential causes and propose an anatomic scoring system that may help to classify patients and prevent complications...
  96. ncbi Interspinous process devices in the lumbar spine
    Christopher M Bono
    Department of Orthopaedic Surgery, Harvard Medical School, Orthopaedic Spine Service, Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Spinal Disord Tech 20:255-61. 2007
    ..In contrast, the purported clinical goals are more variable, ranging from treatment of degenerative spinal stenosis, discogenic low back pain, facet syndrome, disk herniations, and instability...
  97. ncbi Quality of life of lumbar stenosis-treated patients in whom the X STOP interspinous device was implanted
    Ken Y Hsu
    Department of Orthopaedics, St Mary s Medical Center, St Mary s Spine Center, San Francisco, California 94117, USA
    J Neurosurg Spine 5:500-7. 2006
    ..the quality of life (QOL) in patients with neurogenic intermittent claudication (NIC) secondary to lumbar spinal stenosis (LSS)...
  98. pmc Comparison of the predictive value of myelography, computed tomography and MRI on the treadmill test in lumbar spinal stenosis
    Eun Su Moon
    Department of Orthopaedic Surgery, Yongdong Severance Hospital, Yonsei University College of Medicine, Dogok dong, Kangnam Gu, Seoul 135 720, Korea
    Yonsei Med J 46:806-11. 2005
    ..05). Our data showed no statistically significant differences in the correlation of the patients' walking capacity to the severity of stenosis as assessed by myelography, myelo-CT and MRI...
  99. pmc Walking ability during daily life in patients with osteoarthritis of the knee or the hip and lumbar spinal stenosis: a cross sectional study
    Corinna C Winter
    Department of Orthopedics and Tumor Orthopedics, University Hospital Muenster, Albert Schweitzer Str, 33, 48149 Munster, Germany
    BMC Musculoskelet Disord 11:233. 2010
    ..present study was to investigate and compare the impact of three frequent degenerative musculoskeletal disorders--knee osteoarthritis (knee OA), hip osteoarthritis (hip OA) and lumbar spinal stenosis (LSS)--on patients' walking ability.
  100. ncbi One-year results of X Stop interspinous implant for the treatment of lumbar spinal stenosis
    Manal Siddiqui
    Department of Orthopaedics, Woodend Hospital, Aberdeen, Scotland, UK
    Spine (Phila Pa 1976) 32:1345-8. 2007
    ..Prospective observational study...
  101. pmc Insertion loads of the X STOP interspinous process distraction system designed to treat neurogenic intermittent claudication
    Vikram Talwar
    San Francisco Orthopaedic Residency Program, CA, USA
    Eur Spine J 15:908-12. 2006
    ..has been developed to treat patients suffering from neurogenic intermittent claudication secondary to lumbar spinal stenosis. As most patients who suffer from spinal stenosis are over the age of 50 and may have weaker bones, it is ..

Research Grants37

  1. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ..Alongside the registry, we propose to enroll patients into two studies: 1) an RCT of elderly patients with spinal stenosis to evaluate the effectiveness, cost and safety of combined epidural steroid injections and local anesthetics ..
  2. RANDOMIZED CLINICAL TRIAL: TREATMENT FOR SPINAL STENOSIS
    Anthony Delitto; Fiscal Year: 2003
    Lumbar spinal stenosis is a frequently-encountered condition, particularly in the elderly, which can lead to significant pain and functional limitations. The prevalence of this condition is growing as the population continues to age...
  3. Diagnostic Biomarkers for Radicular Pain
    GAETANO JOHN SCUDERI; Fiscal Year: 2010
    ..Common causes of back pain include disc herniation, spinal stenosis, back muscle strain, and disc degeneration...
  4. MECHANISM OF DISC PROTEOGLYCAN LOSS IN A MOUSE MODEL OF ACCELERATED AGING
    Nam V Vo; Fiscal Year: 2011
    ..IDD) contributes to many spinal disorders such as chronic disabling low back pain, disc herniation, spinal stenosis and vertebral instability...
  5. Low Back Pain: A Multi-Center Clinical Trial
    James N Weinstein; Fiscal Year: 2013
    ..of the three most common, disabling and costly low back disorders - intervertebral disc herniation (IDH), spinal stenosis (SpS), and degenerative spondylolisthesis (DS)...
  6. BACK PAIN OUTCOME ASSESSMENT TEAM
    Richard Deyo; Fiscal Year: 1991
    ..Initial studies will focus on spinal stenosis, which is the leading diagnosis associated with both surgical and medical hospitalizations for back pain in ..
  7. Spinal Fusion Using Adipose Derived Adult Stem Cells
    Jeffrey Gimble; Fiscal Year: 2005
    ..orthopedic procedure routinely used to treat back pain in patients suffering from degenerative disc disease, spinal stenosis, scoliosis, and spinal fracture; however, procedure failure rates range between 5 to 44% and the success ..
  8. Magnetic Resonance Imaging Near Metallic Implants
    BRIAN ANDREW HARGREAVES; Fiscal Year: 2010
    ..necrosis, tendon or ligamentous injury, bone or soft tissue lesions, spinal nerve root compression, and spinal stenosis. Unfortunately, in patients with metallic implants, MRI is hampered by metal-induced artifacts (e.g...
  9. Safety-Sensing Independence-Enhancing Wheelchair
    William Kennedy; Fiscal Year: 2004
    ..g., many with MS, quadraplegia, spinal stenosis, visual and other impairments...
  10. MAINE LUMBAR SPINE STUDY
    Robert Keller; Fiscal Year: 2001
    ..MLSS, initially funded as part of the Low Back Pain PORT, enrolled over 600 patients with either sciatica or spinal stenosis in 1990/92...
  11. Assess & Improve the Quality of Care For Low Back Pain
    Nancy Birkmeyer; Fiscal Year: 2004
    ..outcomes for patients undergoing treatment for three surgically treatable spine conditions: herniated disc, spinal stenosis, and degenerative spondylolisthesis...
  12. Clinical Decision Making in Low Back Pain
    Jon Lurie; Fiscal Year: 2006
    ..SPORT) presents a unique opportunity to study the predictors of outcome for patients with herniated discs, spinal stenosis, and degenerative spondylolisthesis...
  13. Safety of Lumbar Fusion Surgery for Chronic Back Pain
    Sohail Mirza; Fiscal Year: 2006
    ..to enroll 1000 patients choosing fusion surgery for treatment of disc degeneration, spondylolisthesis, spinal stenosis, and adult degenerative scoliosis...
  14. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2003
    ..approaches involving pharmacological modulation of cytokine release or synthesis could be developed to control pain in individuals with an acutely herniated lumbar disc, spinal stenosis, tumor, or other injury or disease of the spine.
  15. MULTIFACTOR, QUANTITATIVE ASSESSMENT OF SPINAL STENOSIS
    John Hipp; Fiscal Year: 2000
    ..Approximately 20 percent of hospitalized back pain patients are diagnosed with spinal stenosis. This diagnosis is based on the hypothesis that insufficient space available for neural elements in the spine ..
  16. Functional recovery in spinal stenosis: Understanding the activated patient
    Richard Skolasky; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  17. SECOND PAGET FOUNDATION WORKING GROUP MEETING
    FREDERICK SINGER; Fiscal Year: 1993
    ..to be discussed include neoplasms (sarcoma and giant cell tumors), hearing loss, dental complications and spinal stenosis. The organizing committee will invite medical scientists who are experts in these areas but who previously ..
  18. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lumbar spinal stenosis is known as a common and severely disabling condition affecting older persons...
  19. PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SS
    Andrew Haig; Fiscal Year: 2005
    Objectives: The clinical syndrome of spinal stenosis is a significant problem for older Americans. Although stenosis causes neurogenic claudication, spinal canal size does not accurately predict the severity of symptoms...
  20. Complications of Surgery for Spinal Stenosis: A Clinical Prediction Rule
    Richard A Deyo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Our overarching goal is to improve patient safety in surgery for spinal stenosis. We hope to achieve this by better informing surgeons'and patients'treatment decisions with individualized ..
  21. RAPID MR VS XRAY: RANDOMIZED OUTCOME TRIAL FOR BACK PAIN
    JEFFREY JARVIK; Fiscal Year: 2001
    ..We have a window of opportunity before the rapid MRI becomes widely disseminated and a randomized trial is made impossible by the expectations of both patients and physicians. ..
  22. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  23. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  24. UW Multidisciplinary Clinical Research Training (RMI)
    Richard Deyo; Fiscal Year: 2004
    ....
  25. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  26. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  27. LMP-1 is a critical regulator of BMP signaling and BMP responsiveness
    Scott D Boden; Fiscal Year: 2010
    ....
  28. REGULATION OF BMP-6 IN EARLY OSTEOBLAST DIFFERENTIATION
    Scott Boden; Fiscal Year: 2002
    ..An increased understanding of the BMP-6 promoter may lead to strategies involving oligonucleotide therapy or viral-mediated delivery of factors to enhance expression of BMP-6 locally, or in a targeted population of cells. ..
  29. Prevention of Neck Injuries in Older Adults During Rear Motor Vehicle Collsions
    PAUL IVANCIC; Fiscal Year: 2009
    ..The proposed project will provide important research-based data that may form the basis for future safety standards and help to decrease the frequency and severity of neck injuries in older adults, thus benefiting society. ..
  30. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  31. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  32. PREDICTING DEPRESSION OUTCOMES IN MEDICALLY ILL ELDERS
    Harold Koenig; Fiscal Year: 2003
    ..It will also provide important information to both guide future clinical trials and identify barriers to effective treatment of depression in these patients. ..
  33. EVALUATION OF OSTEOPOROSIS PREVENTION IN THE ELDERLY
    Anna Tosteson; Fiscal Year: 2006
    ..Our proposed research will provide results useful in guiding both osteoporosis-related health policy and patient-centered decision making. ..
  34. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  35. Functional Health CAT in Diabetes
    Carolyn Schwartz; Fiscal Year: 2004
    ..abstract_text> ..
  36. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  37. NIAMS Muiltidisciplinary Clinical Research Center in...
    Richard Deyo; Fiscal Year: 2006
    ..It will require computer modeling, based on precedents in MR-PET scanning. We will determine if surgeons will accept the synthesized images as a replacement for CT-myelography for purposes of surgical planning. ..