osteonecrosis

Summary

Summary: Death of a bone or part of a bone, either atraumatic or posttraumatic.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study
    Valérie Gangji
    Department of Rheumatology and Physical Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Bone 49:1005-9. 2011
  2. ncbi Epidemiology and pathogenesis of osteonecrosis of the jaw
    Ian R Reid
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Rheumatol 8:90-6. 2012
  3. pmc Glucocorticoid-induced osteoporosis and osteonecrosis
    Robert S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, and Central Arkansas Veterans Healthcare System at the University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 587, Little Rock, AR 72205 7199, USA
    Endocrinol Metab Clin North Am 41:595-611. 2012
  4. ncbi Osteonecrosis of the jaw and the role of macrophages
    Michael Pazianas
    Institute of Musculoskeletal Sciences, University of Oxford, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, UK
    J Natl Cancer Inst 103:232-40. 2011
  5. ncbi Pathogenesis and natural history of osteonecrosis
    Yehudith Assouline-Dayan
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Radiology, University of California at Davis, Davis, CA 95616, USA
    Semin Arthritis Rheum 32:94-124. 2002
  6. ncbi Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic
    Robert E Marx
    J Oral Maxillofac Surg 61:1115-7. 2003
  7. ncbi Bisphosphanates and oral cavity avascular bone necrosis
    Cesar A Migliorati
    J Clin Oncol 21:4253-4. 2003
  8. pmc Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia
    Jitesh D Kawedia
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Blood 117:2340-7; quiz 2556. 2011
  9. ncbi Current concepts on the pathogenesis and natural history of steroid-induced osteonecrosis
    Christian Powell
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 41:102-13. 2011
  10. ncbi Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis
    Rene Rizzoli
    University Hospital and Faculty of Medicine, Geneva, Switzerland
    Bone 42:841-7. 2008

Detail Information

Articles from Journal RESEARCH1

Publications353 found, 100 shown here

  1. ncbi Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study
    Valérie Gangji
    Department of Rheumatology and Physical Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Bone 49:1005-9. 2011
    To determine the efficacy of bone marrow cell implantation into the necrotic lesion of the femoral head on clinical symptoms and the progression of osteonecrosis of the femoral head in comparison with core decompression.
  2. ncbi Epidemiology and pathogenesis of osteonecrosis of the jaw
    Ian R Reid
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Rheumatol 8:90-6. 2012
    b>Osteonecrosis of the jaw (ONJ) is defined as exposed bone in the oral cavity that persists despite appropriate therapy...
  3. pmc Glucocorticoid-induced osteoporosis and osteonecrosis
    Robert S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, and Central Arkansas Veterans Healthcare System at the University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 587, Little Rock, AR 72205 7199, USA
    Endocrinol Metab Clin North Am 41:595-611. 2012
    ..administration is the most common cause of secondary osteoporosis and the leading cause of nontraumatic osteonecrosis. In patients receiving long-term therapy, glucocorticoids induce fractures in 30% to 50% and osteonecrosis in ..
  4. ncbi Osteonecrosis of the jaw and the role of macrophages
    Michael Pazianas
    Institute of Musculoskeletal Sciences, University of Oxford, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, UK
    J Natl Cancer Inst 103:232-40. 2011
    Nitrogen-containing bisphosphonates have been associated with the development of osteonecrosis of the jaws (ONJ), but the lack of reliable epidemiological data and appropriate animal models has restricted our understanding of ONJ ..
  5. ncbi Pathogenesis and natural history of osteonecrosis
    Yehudith Assouline-Dayan
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Radiology, University of California at Davis, Davis, CA 95616, USA
    Semin Arthritis Rheum 32:94-124. 2002
    b>Osteonecrosis (avascular necrosis) is a relatively common disorder seen by both rheumatologists and orthopedic surgeons. The vast majority of cases are secondary to trauma...
  6. ncbi Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic
    Robert E Marx
    J Oral Maxillofac Surg 61:1115-7. 2003
  7. ncbi Bisphosphanates and oral cavity avascular bone necrosis
    Cesar A Migliorati
    J Clin Oncol 21:4253-4. 2003
  8. pmc Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia
    Jitesh D Kawedia
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 2794, USA
    Blood 117:2340-7; quiz 2556. 2011
    b>Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic leukemia treatment...
  9. ncbi Current concepts on the pathogenesis and natural history of steroid-induced osteonecrosis
    Christian Powell
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 41:102-13. 2011
    The pathophysiology of non-traumatic osteonecrosis is more complex than that of traumatic osteonecrosis, and corticosteroid-induced osteonecrosis presents the greatest challenge because of the multiple effects of corticosteroids on multi-..
  10. ncbi Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis
    Rene Rizzoli
    University Hospital and Faculty of Medicine, Geneva, Switzerland
    Bone 42:841-7. 2008
    ..a class of drugs used in the treatment of osteoporosis, Paget's disease and metastatic bone disease, is osteonecrosis of the jaw (ONJ)...
  11. ncbi Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity?
    Ian R Reid
    Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Bone 41:318-20. 2007
    b>Osteonecrosis of the jaw (ONJ) is a complication of high-dose bisphosphonate use, characterized by the finding of exposed bone in the oral cavity...
  12. ncbi Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone
    L Qin
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Bone 39:863-71. 2006
    ..and dynamic imaging modalities to study both intra- and extravascular events attributing to steroid-associated osteonecrosis (ON) using an experimental protocol with a single low-dose lipopolysaccharide (LPS) injection and subsequently ..
  13. ncbi Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells
    Dewei Zhao
    Department of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning, 116023, China
    Bone 50:325-30. 2012
    Treatment of early-stage osteonecrosis of the femoral head (ONFH) with autologous implantation of iliac crest bone marrow-derived mononuclear cells, which contain tens of thousands of bone marrow mesenchymal stem cells (BMMSCs), recently ..
  14. pmc Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial
    Leonard A Mattano
    Michigan State University College of Human Medicine, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, MI 49008, USA
    Lancet Oncol 13:906-15. 2012
    ..However, treatments are associated with symptomatic osteonecrosis that disproportionately affects adolescents...
  15. pmc Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia?
    Nathalie Lemonne
    Blood 121:3054-6. 2013
  16. ncbi Oral bisphosphonates as a cause of bisphosphonate-related osteonecrosis of the jaws: clinical findings, assessment of risks, and preventive strategies
    Leon A Assael
    Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    J Oral Maxillofac Surg 67:35-43. 2009
    ..A review of the evidence supporting answers to key clinical questions is necessary to assist surgeons in the care of their patients who are receiving oral bisphosphonates...
  17. ncbi Occurrence of bisphosphonate-related osteonecrosis of the jaw after surgical tooth extraction
    Giorgia Saia
    Unit of Maxillofacial Surgery, University of Padova, Padua, Italy
    J Oral Maxillofac Surg 68:797-804. 2010
    To evaluate the occurrence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients exposed to nitrogen-containing bisphosphonates (NBPs) requiring surgical tooth extraction.
  18. ncbi Osteonecrosis of the jaws by intravenous bisphosphonates and osteoradionecrosis: a comparative study
    Jose V Bagan
    University General Hospital, Valencia University, 46014 Valencia, Spain
    Med Oral Patol Oral Cir Bucal 14:e616-9. 2009
    We analyze the possible clinical differences between bone jaw exposed areas in ONJ (osteonecrosis of the jaws) and ORN (osteoradionecrosis).
  19. pmc Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
    Philippe Hernigou
    Department of Orthopaedic Surgery, University Paris XII, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Clin Orthop Relat Res 468:1676-81. 2010
    Septic arthritis is a known complication of sickle cell disease (SCD) in children, and the association with osteomyelitis and osteonecrosis has been described. However, it is unclear whether this association applies to adults.
  20. ncbi Nd:YAG laser biostimulation in the treatment of bisphosphonate-associated osteonecrosis of the jaw: clinical experience in 28 cases
    Paolo Vescovi
    Unit of Oral Pathology and Medicine, Section of Dentistry, Department of ENT Dental Ophthalmological and Cervico Facial Sciences, University of Parma, Parma, Italy
    Photomed Laser Surg 26:37-46. 2008
    To research an efficient treatment for the management of bisphosphonate-associated osteonecrosis.
  21. ncbi Jaw osteonecrosis associated with bisphosphonates: multiple exposed areas and its relationship to teeth extractions. Study of 20 cases
    Jose V Bagan
    Oral Oncol 42:327-9. 2006
  22. ncbi Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis
    Charles J Glueck
    Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    J Bone Joint Surg Am 90:2220-9. 2008
    ..hypofibrinolysis, and the endothelial nitric oxide synthase (eNOS) T-786C polymorphism are common, potentially treatable, and similar pathophysiologic causes of multifocal (three sites or more) and unifocal (single-site) osteonecrosis.
  23. pmc Bisphosphonates cause osteonecrosis of the jaw-like disease in mice
    Yanming Bi
    University of Maryland School of Medicine, 800 W Baltimore Street, Baltimore, MD 21201, USA
    Am J Pathol 177:280-90. 2010
    Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is a morbid bone disease linked to long-term bisphosphonate use. Despite its broad health impact, mechanistic study is lacking...
  24. ncbi Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?
    Philippe Lesclous
    Laboratoire Réparation et Remodelages Oro Faciaux, EA2496, Universite Paris Descartes, Faculte de Chirurgie Dentaire, France
    Bone 45:843-52. 2009
    b>Osteonecrosis of the jaw (ONJ) can be associated with nitrogen-containing bisphosphonates (NBPs) therapy. Various mechanisms of NBP-associated ONJ have been proposed and there is currently no consensus of the underlying pathogenesis...
  25. ncbi Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofa
    Toshiyuki Yoneda
    Department of Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Bone Miner Metab 28:365-83. 2010
    ..in patients with cancer or osteoporosis who have been receiving intravenous or oral BPs are associated with osteonecrosis of the jaw (bisphosphonate-related osteonecrosis of the jaw, BRONJ)...
  26. ncbi Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry
    Parish P Sedghizadeh
    Division of Diagnostic Sciences, University of Southern California School of Dentistry, Los Angeles, Calif, USA
    J Am Dent Assoc 140:61-6. 2009
    Initial reports of osteonecrosis of the jaw (ONJ) secondary to bisphosphonate (BP) therapy indicated that patients receiving BPs orally were at a negligible risk of developing ONJ compared with patients receiving BPs intravenously...
  27. ncbi Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome
    N Yarom
    Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Osteoporos Int 18:1363-70. 2007
    b>Osteonecrosis of the jaw (ONJ) is a well-known devastating side effect of bisphosphonate therapy for cancer. Several ONJ cases of patients using oral bisphosphonates have been reported in the literature...
  28. ncbi Use of platelet-rich plasma in the management of oral biphosphonate-associated osteonecrosis of the jaw: a report of 2 cases
    Cameron Y S Lee
    J Oral Implantol 33:371-82. 2007
    ..growing number of articles in the worldwide medical and dental literature describing the complication of an osteonecrosis of the jaws associated with the intravenous and, most recently, the oral form of BP medication that has been ..
  29. pmc The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads
    Jessica E Goetz
    Department of Orthopaedics and Rehabilitation, University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242 1100, USA
    J Biomech 41:2197-205. 2008
    Cryoinsult-induced osteonecrosis (ON) in the emu femoral head provides a unique opportunity to systematically explore the pathogenesis of ON in an animal model that progresses to human-like femoral head collapse...
  30. ncbi Bisphosphonate-induced osteonecrosis of the jaw: a medical enigma?
    Allauddin Siddiqi
    Oral Implantology Research Group, Sir John Walsh Research Institute, School of Dentistry, University of Otago, Dunedin, New Zealand
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e1-8. 2009
    ..Bisphosphonate-induced osteonecrosis (BION) is a serious complication...
  31. ncbi Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice
    Yasuyoshi Kobayashi
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Bone Miner Metab 28:165-75. 2010
    ..that cancer patients who have received these bisphosphonates occasionally manifest bisphosphonate-related osteonecrosis of the jaw (BRONJ) following dental treatments, including tooth extraction...
  32. ncbi Osteonecrosis development in a novel rat model characterized by a single application of oxidative stress
    Toru Ichiseki
    Kanazawa Medical University, Uchinada, Japan
    Arthritis Rheum 63:2138-41. 2011
    To investigate the relationship between transient oxidative stress and the development of osteonecrosis in a rat model.
  33. ncbi Glucocorticoid inhibits bone regeneration after osteonecrosis of the femoral head in aged female rats
    Reiko Takano-Murakami
    Department of Regenerative and Transplant Medicine, Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Tohoku J Exp Med 217:51-8. 2009
    Idiopathic osteonecrosis of the femoral head (ION) is a painful disease of the hip, the pathogenic mechanism of which is still unclear. The most common extraneous factor is steroid treatment...
  34. pmc Assessment of corticosteroid-induced osteonecrosis in children undergoing chemotherapy for acute lymphoblastic leukemia: a report from the Japanese Childhood Cancer and Leukemia Study Group
    Nobuyuki Hyakuna
    Center of Bone Marrow Transplantation, Hospital of University of the Ryukyus, Okinawa, Japan
    J Pediatr Hematol Oncol 36:22-9. 2014
    Steroid-induced osteonecrosis (ON) is a challenging complication encountered during modern chemotherapy for childhood acute lymphoblastic leukemia (ALL)...
  35. pmc Different differentiation of stroma cells from patients with osteonecrosis: a pilot study
    Ching Hua Yeh
    Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Orthop Relat Res 467:2159-67. 2009
    b>Osteonecrosis (ON) is commonly caused by high doses of glucocorticoids or ethanol intake...
  36. ncbi Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone
    Chih Kuang Wang
    Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan
    Biomaterials 30:4178-86. 2009
    Untreated osteonecrosis of the hip causes collapse of the femoral head and eventually leads to the development of premature degenerative arthritis...
  37. pmc Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment
    K Oinuma
    Department of Orthopaedic Surgery, Chiba University School of Medicine, Japan
    Ann Rheum Dis 60:1145-8. 2001
    To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE).
  38. ncbi Free microvascular iliac crest flap for extensive talar necrosis--case report with a 16-year long-term follow up
    Ulrich M Rieger
    Department of Plastic and Reconstructive Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria
    Microsurgery 29:667-71. 2009
    Atraumatic osteonecrosis of the talus can be extremely painful and lead to significant functional impairment...
  39. ncbi Denosumab osteonecrosis of the mandible: a new entity? A case report
    Sarina E C Pichardo
    Department of Oral and Maxillofacial Surgery, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Craniomaxillofac Surg 41:e65-9. 2013
    ..Despite surgical treatment fistula and exposed bone remained. This case illustrates that use of denosumab can lead to a type of osteonecrosis resembling bisphosphonate related osteonecrosis of the jaws.
  40. ncbi Bisphosphonates as treatment of bone metastases
    Ingunn Holen
    Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Sheffield, S10 2SJ, UK
    Curr Pharm Des 16:1262-71. 2010
    ..We also give an overview of the use of bisphosphonates in the treatment of breast cancer, including examples of key clinical trials. The potential side effects and future clinical applications of bisphosphonates will be outlined...
  41. pmc Treatment of spontaneous osteonecrosis of the knee (SPONK) by a bisphosphonate
    Jan Jureus
    Department of Orthopedics, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
    Acta Orthop 83:511-4. 2012
    Primary spontaneous osteonecrosis of the knee is a painful lesion in the elderly without any known cause. The onset of pain is usually acute...
  42. ncbi Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw
    Niall M H McLeod
    Oral and Maxillofacial Surgery Department, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, UK
    Br J Oral Maxillofac Surg 49:335-42. 2011
    Despite the increasing number of cases of osteonecrosis of the jaws related to bisphosphonate therapy described in the literature there is a paucity of evidence-based treatment for the condition...
  43. ncbi Angiogenic microRNA-210 is present in cells surrounding osteonecrosis
    Keiichiro Yamasaki
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Orthop Res 30:1263-70. 2012
    ..expression pattern of miRNA (miR)-210, known to be associated with angiogenesis, in bone from patients with osteonecrosis (ON) of the femoral head...
  44. ncbi Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis
    Xin Hui Xie
    The Chinese University of Hong Kong, Hong Kong, China
    Arthritis Rheum 64:1562-71. 2012
    Cytotherapy is an insufficient method for promoting bone repair in steroid-associated osteonecrosis (SAON), and this has been attributed to impairment of the bioactivity of bone marrow-derived stem cells (BMSCs) after pulsed ..
  45. pmc Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat
    Tara L Aghaloo
    Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    J Bone Miner Res 26:1871-82. 2011
    ..density, reduce fracture risk, and reduce hypercalcemia of malignancy, some patients develop BP-related osteonecrosis of the jaws (BRONJ)...
  46. ncbi Bisphosphonate related osteonecrosis of the jaw--manifestation in a microvascular iliac bone flap
    Christoph Pautke
    Department of Oral and Maxillofacial Surgery, University of Munich, Lindwurmstr 2a, D 80337 Munich, Germany
    Oral Oncol 47:425-9. 2011
    Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a side effect that may emerge due to a long-term bisphosphonate therapy...
  47. ncbi A novel case of bisphosphonate-related osteonecrosis of the torus palatinus in a patient with metastatic breast cancer
    Matthew L Goldman
    Breast Cancer Section, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA
    Oncology 71:306-8. 2006
    ..Long-term intravenous use of bisphosphonates has been shown to cause osteonecrosis of the jaw...
  48. ncbi Nonexposed bisphosphonate-related osteonecrosis of the jaws: another clinical variant?
    Luis Junquera
    University of Oviedo Dental School, Oviedo, Spain
    J Oral Maxillofac Surg 66:1516-7. 2008
  49. pmc Glucocorticoid-induced osteonecrosis
    Robert S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Endocrine 41:183-90. 2012
    ..is growing, but glucocorticoid administration is often overlooked as the most common cause of nontraumatic osteonecrosis. Glucocorticoid-induced osteonecrosis develops in 9-40% of patients receiving long-term therapy although it ..
  50. ncbi Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw
    J Katz
    Department of Oral Medicine, College of Dentistry, University of Florida, Gainesville, USA
    Int J Oral Maxillofac Surg 40:605-11. 2011
    Bisphosphonate induced osteonecrosis of the jaw (BONJ) is a complication in patients taking bisphosphonate (BP) that affects their quality of life and compliance...
  51. ncbi Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw
    T Ziebart
    Klinik fur Mund, Kiefer und Gesichtschirurgie Plastische Operationen, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Germany
    Oral Oncol 47:195-201. 2011
    Bisphosphonate associated osteonecrosis of the jaw (BP-ONJ) is one of the main side effects of bisphosphonate therapy (BPT). To date, there is no effective therapy of the BP-ONJ...
  52. pmc Lipid metabolism abnormalities in alcohol-treated rabbits: a morphometric and haematologic study comparing high and low alcohol doses
    Satoshi Ikemura
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Int J Exp Pathol 92:290-5. 2011
    The pathogenesis of alcohol-induced osteonecrosis remains unclear. The purpose of the present study was to evaluate the morphological changes in bone marrow fat cells and the changes in the serum lipid levels in alcohol-treated rabbits...
  53. pmc A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Deborah French
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 338105 2794, USA
    Blood 111:4496-9. 2008
    As glucocorticoid use increased in acute lymphoblastic leukemia, osteonecrosis became an increasingly frequent complication. Besides increased age, host risk factors are poorly defined...
  54. ncbi Prospective study on incidence, risk factors, and long-term outcome of osteonecrosis in pediatric acute lymphoblastic leukemia
    Mariel L te Winkel
    Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    J Clin Oncol 29:4143-50. 2011
    We studied cumulative incidence, risk factors, therapeutic strategies, and outcome of symptomatic osteonecrosis in pediatric patients with acute lymphoblastic leukemia (ALL).
  55. ncbi Functional perfusion MRI predicts later occurrence of steroid-associated osteonecrosis: an experimental study in rabbits
    Hui Sheng
    Musculoskeletal Research Laboratory of the Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Orthop Res 27:742-7. 2009
    Ischemia is the defined pathway leading to steroid-associated osteonecrosis (ON). Early detection of ischemic condition may help predict later ON occurrence...
  56. ncbi Sinus tracts--an early sign of bisphosphonate-associated osteonecrosis of the jaws?
    Hani Mawardi
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
    J Oral Maxillofac Surg 67:593-601. 2009
    Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is defined as the presence of exposed bone for at least 8 weeks in patients with exposure to bisphosphonates and no history of radiotherapy to the jaw...
  57. ncbi Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: a case series
    Stefano Fedele
    University College London Eastman Dental Institute, London, UK
    Am J Med 123:1060-4. 2010
    To report a case series of patients with the nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw-a form of jaw osteonecrosis that does not manifest with necrotic bone exposure/mucosal fenestration.
  58. ncbi A systematic review of bisphosphonate osteonecrosis (BON) in cancer
    Cesar Augusto Migliorati
    Department of Biologic and Diagnostic Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Support Care Cancer 18:1099-106. 2010
    This systematic review aims to examine the prevalence of bisphosphonate osteonecrosis (BON) in the cancer population, prevention and treatment protocols, and quality of life issues.
  59. ncbi Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy
    Marie Hélène Vieillard
    Rheumatology Department, Lille Teaching Hospital, Hospital Roger Salengro, CHRU de Lille, Rue Emile Laine, 59037 Lille Cedex, France
    Joint Bone Spine 75:34-40. 2008
    We report on our experience with 13 cases of jaw osteonecrosis in patients treated with amino-bisphosphonates.
  60. ncbi Pathobiology and prevention of cancer chemotherapy-induced bone growth arrest, bone loss, and osteonecrosis
    C Fan
    Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5001, Australia
    Curr Mol Med 11:140-51. 2011
    ..and basic studies that appeared from 1990 to 2010 were reviewed for bone defects (growth arrest, bone loss, osteonecrosis, and/or fractures) caused by paediatric cancer chemotherapy...
  61. ncbi Oxidative stress by glutathione depletion induces osteonecrosis in rats
    T Ichiseki
    Department of Orthopaedic Surgery, Kanazawa Medical University, Ishikawa, Japan
    Rheumatology (Oxford) 45:287-90. 2006
    We recently implicated in vivo oxidative stress in the development of osteonecrosis in a steroid-induced osteonecrosis model in the domestic rabbit...
  62. ncbi Bisphosphonate-associated osteonecrosis of the jaw. A proposal for conservative treatment
    Sacramento Bocanegra Pérez
    Hospital Universitario Insular, Centro de Ciencias de la Salud, Las Palmas de Gran Canaria, Spain
    Med Oral Patol Oral Cir Bucal 13:E770-3. 2008
    ..BPs) has proven effective in the treatment of bone-related diseases, despite the potential risk of developing osteonecrosis of the jaw (ONJ). So far, results for the treatment of ONJ have not been satisfactory...
  63. ncbi Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis
    J Sarin
    Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Oral Dis 14:277-85. 2008
    b>Osteonecrosis of the jaws is a major complication associated with long-term use of bisphosphonates...
  64. ncbi Bisphosphonate-related osteonecrosis of the jaw: clinical features, risk factors, management, and treatment outcomes of 26 patients
    Vivek Thumbigere-Math
    Division of Periodontology, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    J Oral Maxillofac Surg 67:1904-13. 2009
    To report the clinical features, risk factors, management, and treatment outcomes of nitrogen-containing bisphosphonate (n-BIS)-related osteonecrosis of the jaw (BRONJ).
  65. pmc Long-term results of decompression and muscle-pedicle bone grafting for osteonecrosis of the femoral head
    Durgapada P Baksi
    DA 3, Sector I, Salt Lake City, Kolkata, 700064, India
    Int Orthop 33:41-7. 2009
    ..4% in stage III, with a survivorship of 91% in Stage II and 82% in Stage III cases. The patients having an HSS score below 20 (non-survival) were recommended for total hip replacement (THR) therapy...
  66. ncbi Osteonecrosis of the jaw (ONJ) in cancer patients treated with Bisphosphonates: how the knowledge of a phenomenon can change its evolution
    Nicla La Verde
    Oncology Department, Azienda Ospedaliera Ospedale Fatebenefratelli e Oftalmico, Milan, Italy
    Support Care Cancer 16:1311-5. 2008
    b>Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonates treatment. Bisphosphonates reduce skeletal adverse events and give a clinical benefit to cancer patients...
  67. ncbi Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws
    Robert E Marx
    Division of Oral and Maxillofacial Surgery, University of Miami Miller School of Medicine, Miami, FL 33137, USA
    J Oral Maxillofac Surg 67:107-19. 2009
    Reconstructive surgery of defects for any disease or injury including bisphosphonate-induced osteonecrosis of the jaws requires an understanding of the pathophysiology of the condition...
  68. ncbi The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws
    Eric R Carlson
    Department of Oral and Maxillofacial Surgery, University of Tennessee Medical Center and University of Tennessee Cancer Institute, Knoxville, TN 37920, USA
    J Oral Maxillofac Surg 67:85-95. 2009
    Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a poorly understood pathologic entity from the standpoints of its nomenclature, frequency, pathogenesis, and best method of treatment...
  69. pmc Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head
    Jung Min Hong
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700 412, Korea
    Exp Mol Med 42:376-85. 2010
    Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply to the femoral head...
  70. ncbi Bisphosphonates and osteonecrosis of the jaws: science and rationale
    Rajesh Gutta
    Oral and Maxillofacial Surgery, University of Alabama, Birmingham, AL, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:186-93. 2007
    ..The controversy of osteonecrosis of the jaws and bisphosphonates is a recent and growing problem...
  71. ncbi Bisphosphonate associated osteonecrosis: an unusual case
    P Mehanna
    Department of Oral and Maxillofacial Surgery, John Hunter Hospital, Newcastle, New South Wales, Australia
    Aust Dent J 55:311-3. 2010
    The management of bisphosphonate associated osteonecrosis of the jaws (bisphosphonate associated ONJ) is emerging as a significant problem in the field of dentistry and oral and maxillofacial surgery...
  72. ncbi Surgery-triggered and non surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Italian multicenter study
    Paolo Vescovi
    Department of Otolaryngological Dental Ophthalmological and Cervico Facial Sciences, University of Parma, Parma, Italy
    Oral Oncol 47:191-4. 2011
    ..local procedures are often reported in clinical history of patients suffering from Bisphosphonates-Related Osteonecrosis of the Jaws (BRONJ) but over 40% of spontaneous forms have been also described in literature...
  73. ncbi Osteonecrosis: etiology, diagnosis, and treatment
    Lynne C Jones
    Center for Osteonecrosis Research and Education, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Rheumatol 16:443-9. 2004
    This review provides an update of the recent progress in etiology, pathogenesis, diagnosis, and treatment of osteonecrosis.
  74. pmc ACTH protects against glucocorticoid-induced osteonecrosis of bone
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:8782-7. 2010
    We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol)...
  75. ncbi Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats
    David G Little
    Orthopaedic Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Sydney, Australia
    J Bone Miner Res 18:2016-22. 2003
    b>Osteonecrosis (ON) of the femoral head in childhood can lead to loss of femoral head architecture and subsequent deformity...
  76. ncbi Surgical management of bisphosphonate induced osteonecrosis of the jaws
    R A Williamson
    Department of Oral Surgery, Faculty of Medicine and Dentistry, University of Western Australia, 17 Monash Avenue, Perth, WA 6009, Australia
    Int J Oral Maxillofac Surg 39:251-5. 2010
    Recent literature contains numerous articles on osteonecrosis of the jaws (ONJ) associated with bisphosphonate treatment (BPT), with most advocating a conservative approach to management...
  77. ncbi Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action
    Mohammad Amin Kerachian
    Department of Human Genetics, McGill University Health Center, Montreal, Canada
    J Steroid Biochem Mol Biol 114:121-8. 2009
    Glucocorticoid (GC) usage is the most common non-traumatic cause of osteonecrosis of the femoral head (ON). Despite the strong association of GC with ON, the underlying mechanisms have been unclear...
  78. ncbi Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia
    J W Hong
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Osteoporos Int 21:847-53. 2010
    Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of bisphosphonate therapy. The incidence of BRONJ is known to be low among patients treated with oral bisphosphonates...
  79. ncbi Very early development of steroid-associated osteonecrosis of femoral head in systemic lupus erythematosus: prospective study by MRI
    K Nagasawa
    Department of Internal Medicine, Saga Medical School, Saga, Japan
    Lupus 14:385-90. 2005
    The objective of this study was to define prospectively the early development of corticosteroid-induced osteonecrosis of femoral head (ONF) in patients with systemic lupus erythematosus (SLE) and to identify the association of initial ..
  80. ncbi Alendronate prevents collapse in mechanically loaded osteochondral grafts: a bone chamber study in rats
    Magnus Tagil
    Departments of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    Acta Orthop Scand 75:756-61. 2004
    Subchondral bone necrosis is important in osteonecrosis, Mb Kienboeck, intraarticular fractures or osteochondral grafting. As revascularization follows, bone resorption may lead to collapse in load bearing areas during the remodeling...
  81. ncbi Serologic bone markers for predicting development of osteonecrosis of the jaw in patients receiving bisphosphonates
    Towy Sorel Lazarovici
    Resident, Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, Israel
    J Oral Maxillofac Surg 68:2241-7. 2010
    b>Osteonecrosis of the jaw is a well-documented side effect of bisphosphonate (BP) use. Attempts have recently been made to predict the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ)...
  82. ncbi Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw
    J Compston
    Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK
    Osteoporos Int 22:2951-61. 2011
    In recent years, atypical femoral fractures and osteonecrosis of the jaw have emerged as potential complications of long-term bisphosphonate therapy; osteonecrosis of the jaw has also been reported in patients receiving high doses of ..
  83. ncbi Bisphosphonate-related osteonecrosis of the jaws: a case series of 25 patients affected by osteoporosis
    M Manfredi
    Oral Medicine, Oral Pathology and Laser Assisted Surgery Unit, University of Parma, Italy
    Int J Oral Maxillofac Surg 40:277-84. 2011
    ..In this study the occurrence of bisphosphonates-related osteonecrosis of the jaws (BRONJ) is reported in 25 patients who received BP therapy for osteoporosis with different drug ..
  84. pmc Vasculature deprivation--induced osteonecrosis of the rat femoral head as a model for therapeutic trials
    Jacob Bejar
    Department of Pathology, the Bnai Zion Medical Center, The Bruce Rapapport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Theor Biol Med Model 2:24. 2005
    EXPERIMENTAL OSTEONECROSIS: The authors' experience with experimentally produced femoral capital osteonecrosis in rats is reviewed: incising the periosteum at the base of the neck of the femur and cutting the ligamentum teres leads to ..
  85. ncbi Possible association between diabetes and bisphosphonate-related jaw osteonecrosis
    Mogher Khamaisi
    Department of Internal Medicine B and the Diabetes Center, Hebrew University Hadassah Medical Center, Kiryat Hadassah, P O Box 12000, Jerusalem 91120, Israel
    J Clin Endocrinol Metab 92:1172-5. 2007
    Bisphosphonate-related osteonecrosis (BON) of the jaws is a newly identified condition for which the exact mechanism involved in its pathogenesis remains obscure.
  86. ncbi Differential impairment of vascularization and angiogenesis in bisphosphonate-associated osteonecrosis of the jaw-related mucoperiosteal tissue
    Falk Wehrhan
    Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:216-21. 2011
    Impaired vascularization in the etiopathology of aminobisphosphonate-associated osteonecrosis of the jaw (BONJ) is assumed, but evidence is lacking...
  87. ncbi Early MRI diagnosis and non-surgical management of spontaneous osteonecrosis of the knee
    Piers J Yates
    North Hampshire Hospital, Basingstoke, Hampshire, UK
    Knee 14:112-6. 2007
    Spontaneous osteonecrosis of the knee (SONK) is generally associated with a poor prognosis but the outcome depends on the clinical and radiological stage at which the patients present...
  88. ncbi The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors
    Michael C Adornato
    Faxton St Luke s Healthcare Dental Service, New Hartford, NY, USA
    J Am Dent Assoc 138:971-7. 2007
    ..Bisphosphonates are bone resorption inhibitors and have been associated with osteonecrosis of the jaws...
  89. ncbi Angiogenic suppression of osteoclasts may play a role in developing bisphosphonate-related osteonecrosis of the jaw
    Guozhu Yin
    State Key Laboratory of Oral Disease, Sichuan University, Renmin South Avenue, Chengdu 610041, Sichuan Province, PR China
    Med Hypotheses 76:347-9. 2011
    ..it was firstly reported in 2003, a large number of cases have been published concerning bisphosphonate-related osteonecrosis of the jaw (BRONJ)...
  90. ncbi Bisphosphonate-associated oral osteonecrosis
    Cesar Augusto Migliorati
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:135. 2005
  91. ncbi The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data
    Matthew R Allen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Oral Maxillofac Surg 67:61-70. 2009
    Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has generated great interest in the medical and research communities yet remains an enigma, given its unknown pathogenesis...
  92. ncbi Avascular jaw osteonecrosis in association with cancer chemotherapy: series of 10 cases
    J V Bagan
    Department of Stomatology, Oral Medicine, University General Hospital, Valencia University, Valencia, Spain
    J Oral Pathol Med 34:120-3. 2005
    We present a series of 10 patients with osteonecrosis of the jaws (ONJ) that appeared following cancer chemotherapy.
  93. ncbi Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats
    Alessandra Bitto
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c o AOU Policlinico G Martino, Messina, Italy
    J Endocrinol 201:321-8. 2009
    ..We investigated whether GEN could prevent GIO as well as the development of osteonecrosis in the femoral head using an experimental rat model...
  94. ncbi Treatment results of bisphosphonate-related osteonecrosis of the jaws
    Arno Wutzl
    University Hospital of Cranio, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria
    Head Neck 30:1224-30. 2008
    b>Osteonecrosis of the jaws occurs after the administration of bisphosphonates. An unequivocal treatment strategy is yet to be devised. We assess the treatment of patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ).
  95. ncbi Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: not just a sporadic coincidence--a multi-centre study
    Sven Otto
    Department of Oral and Maxillofacial Surgery, University of Munich, Lindwurmstr 2a, D 80336 Munich, Germany
    J Craniomaxillofac Surg 39:272-7. 2011
    ..Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ)...
  96. ncbi Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw
    Beatrice J Edwards
    Divisions of Hematology Oncology and Geriatric Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL USA
    Lancet Oncol 9:1166-72. 2008
    ..reports of nine patients with cancer, who were treated with zoledronic acid, who unexpectedly developed osteonecrosis of the jaw...
  97. ncbi Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals
    Christos Magopoulos
    Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
    Am J Otolaryngol 28:158-63. 2007
    ..The only clinical feature common in all patients was the use of bisphosphonates in the treatment of bone diseases...
  98. ncbi Bisphosphonate-related osteonecrosis of the jaw: diagnosis, prevention, and management
    Salvatore L Ruggiero
    New York Center for Orthognathic and Maxillofacial Surgery, Lake Success, New York 11042, USA
    Annu Rev Med 60:85-96. 2009
    ..has raised concerns about potential side effects related to profound bone remodeling inhibition and osteonecrosis isolated to the jaws...
  99. pmc Factors associated with osteonecrosis of the jaw among bisphosphonate users
    Lisa M Hess
    College of Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Med 121:475-483.e3. 2008
    Bisphosphonates are medications that impact bone reformation by inhibiting osteoclast function. Osteonecrosis of the jaw has been reported among patients receiving these medications...
  100. ncbi The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program
    John T Grbic
    Columbia University College of Dental Medicine, New York City, NY 10032, USA
    J Am Dent Assoc 141:1365-70. 2010
    ..Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly-Pivotal Fracture Trial found one case of osteonecrosis of the jaw (ONJ) in a patient with postmenopausal osteoporosis (OP) treated with 5 milligrams of zoledronic ..
  101. pmc Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice
    Takashi Kikuiri
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA
    J Bone Miner Res 25:1668-79. 2010
    ..on high-dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology remains unknown, and appropriate therapy ..

Research Grants64

  1. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..speculate that the unique physical characteristics of the mouth and alveolar bone can provide a link between osteonecrosis of the jaw and cherubism...
  2. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..other cancers and Paget's disease of bone, have a severe side effect called bisphosphonate- associated osteonecrosis of the jaw via undefined mechanism(s)...
  3. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..discrete location of these lesions may have important implications for understanding the pathophysiology of osteonecrosis of the jaw...
  4. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..information is available on bone remodeling in the human craniofacial skeleton, nor the mechanisms involved in osteonecrosis of the jaw and there are few effective treatments...
  5. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..by applicant): Bone destruction is a theme central to many bone-related conditions such as osteoporosis, osteonecrosis of the jaw, stress fractures and osteolysis...
  6. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..Furthermore, many of these drugs have serious side effects (e.g., breast cancer from estrogen therapy, osteonecrosis of the jaw and delayed healing from bisphosphonate-based drugs)...
  7. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..disorders (stroke, myocardial infarction), diabetes, connective tissue disorders (cartilage defects, osteonecrosis, limb ischemia), chronic obstructive pulmonary disease, nervous system disorders (multiple sclerosis, ..
  8. Salivary Biomarkers in the Diagnosis of BRONJ
    Tara L Aghaloo; Fiscal Year: 2013
    ..Her current R01 grant focuses on the pathophysiology of bisphosphonate related osteonecrosis of the jaws (BRONJ), by studying both in vitro mechanisms of osteoclast inhibition by bisphosphonates (BPs) ..
  9. Oral Mucosa in Bisphosphonate-associated Osteonecrosis of the Jaw
    Kotaro Sena; Fiscal Year: 2010
    Bisphosphonate-associated osteonecrosis of the jaw (ONJ) adversely affects the quality of life and produces significant morbidity in afflicted patients. It is characterized by the finding of exposed alveolar bone in the oral cavity...
  10. Mesenchymal Regulation of Jaw Bone Length
    Erin L Ealba; Fiscal Year: 2013
    ..has implications for repair and regeneration of bones injured by trauma or diseases like osteoporosis and osteonecrosis. We are hopeful that our research will provide a foundation for biologically based, non-surgical methods to ..
  11. Transcriptional Regulation of Osteoclast Lineage Commitment and Differentiation
    Yi Ping Li; Fiscal Year: 2013
    ..g., jaw osteonecrosis) of currently used osteoclast inhibitors may outweigh the benefits...
  12. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2013
    ..effects can occur with systemic administration in humans such as inhibition of all skeletal remodeling and osteonecrosis of the jaw...
  13. Pathophysiologic mechanisms of biosphosphonate related osteonecrosis of the jaws
    Sotirios Tetradis; Fiscal Year: 2012
    ..bone mineral density, reduce fracture risk, and reduce hypercalcemia of malignancy, many patients develop osteonecrosis of the jaws...
  14. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..objective of this project is to establish an innovative therapeutic approach toward glucocorticoid-induced osteonecrosis of the femoral head (ONFH), using nano-fullerenes which function as outstanding reactive oxygen species (ROS) ..
  15. Intracellular trafficking of Bisphosphonates in bone mesenchymal Stem Cells
    Sunday O Akintoye; Fiscal Year: 2013
    ..Unfortunately, osteonecrosis of the jaw (ONJ) is a major complication of n-BP therapy...
  16. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
    ..inhibiting Th17 cells, and consequently, suppress tissue destruction in our inflammation-related tissue injury/osteonecrosis model induced by bisphosphonate (BRONJ)...
  17. Oral Mucosa Barrier and Bisphosphonate-related Osteonecrosis of the Jaw
    Ichiro Nishimura; Fiscal Year: 2013
    ..In the recent years, there have been a number of cases reporting osteonecrosis of the jaw (ONJ) subsequent to nitrogen-containing BP treatment...
  18. Bisphosphonate-related osteonecrosis of the jaw: Bridging the clinical-preclinica
    Matthew R Allen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bisphosphonate-related osteonecrosis of the jaw (BRONJ), the presence of exposed bone in the oral cavity with current/previous bisphosphonate treatment and without prior exposure to radiation, has ..
  19. Bone Turnover Effects on Bisphosphonate Concentration in the Mandible
    Kenneth M Kozloff; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Osteonecrosis of the jaw (ONJ) is an emerging condition that has been associated with bisphosphonate use, typically in the context of cancer treatment...
  20. Mesenchymal Regulation of Osteogenesis
    Richard A Schneider; Fiscal Year: 2013
    ..has implications for repair and regeneration of bones injured by trauma or diseases like osteoporosis and osteonecrosis. We are hopeful that our research will provide a foundation for biologically based, non-surgical methods to ..
  21. Pathophysiology of Biphosphonate-Induced ONJ in a Novel Animal Model
    J Ignacio Aguirre; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In recent years, osteonecrosis of the jaw (ONJ) has been identified as a potential complication of bisphosphonate (BP) treatment...
  22. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..and kidney toxicity in the case of NSAIDS, somnolence, constipation and nausea for narcotics and osteoporosis, osteonecrosis, diabetes, cataracts and atherosclerosis for corticosteroids...
  23. Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing Trial
    Cheryl Lorane Cox; Fiscal Year: 2013
    ..g., diabetes, osteonecrosis, osteoporosis, cardiovascular disease)...
  24. Deep South Musculoskeletal (DSM) CERTs
    Kenneth G Saag; Fiscal Year: 2010
    ..Patients by a High-intensity Intervention;(c) Defining Serious Adverse Events from Biologic Therapies;and (d) Osteonecrosis of the Jaw: An Emerging Threat for Bisphosphonate Users;2) Educate health care practitioners, insurers, and ..
  25. Tissue engineering application of endochondral ossification for bone regeneration
    CHELSEA SHIELDS BAHNEY; Fiscal Year: 2013
    ..tissue with poor vascularity and poor host integration that leads to clinical failures associated with osteonecrosis or dislodgement...
  26. Modeling fracture prediction in spinal cord injury and disease
    Laura D Carbone; Fiscal Year: 2013
    ..Recently, serious side effects from pharmacological therapies for osteoporosis including osteonecrosis of the jaw and atypical femoral fractures have been reported...
  27. Molecular mechanisms of drug-induced ONJ and osteomucosal chronic wounds
    REUBEN HAN KYU KIM; Fiscal Year: 2013
    ..accumulate at the alarming rate that certain drugs used to treat bone- associated diseases specifically induce osteonecrosis of the jaw (ONJ) and delay wound healing of oral mucosa, leading to considerable clinical complications and ..
  28. Glucocorticoid Regimens and Cardiovascular Risk
    Steven C Vlad; Fiscal Year: 2013
    ..million persons, all with detailed pharmacy records, to study the risks of various GC regimens on developing osteonecrosis. Here, we will extend this research, using methods currently being piloted, to assess the risk of different GC ..
  29. Effectiveness of DiscontinuinG bisphosphonatEs Study (EDGE)
    Kenneth G Saag; Fiscal Year: 2013
    ..certain fractures types, and safety concerns have emerged about longer-term use of these agents, particularly osteonecrosis of the jaw and atypical femur fractures...
  30. Glucocorticoids in Lymphoblastic Leukemia
    Mary V Relling; Fiscal Year: 2013
    ..major dose-limiting adverse effect of glucocorticoids in modern ALL clinical trials is glucocorticoid-induced osteonecrosis or avascular necrosis...
  31. Osteonecrosis of the Jaw in Non-Cancer Patients Using Bisphosphonates
    DANIEL HAL SOLOMON; Fiscal Year: 2010
    Bisphosphonates are the most common treatment for osteoporosis. In the last few years, increasing reports of osteonecrosis of the jaw (ONJ) have raised considerable concerns regarding the long-term safety of these agents...
  32. Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients with Metastatic Cancer
    Catherine H Van Poznak; Fiscal Year: 2013
    ..clinical and genetic data to establish an individualized patient specific profile of risk for developing osteonecrosis of the jaw (ONJ), an oral lesion with exposed, necrotic bone...
  33. Antiresorptive-Induced Fragile Oral Wound Healing
    Junro Yamashita; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteonecrosis of the jaw (ONJ) is associated with antiresorptive therapy. The pathophysiology of ONJ is unknown and no established treatment is currently available...
  34. UHMWPE Composite Materials for Joint Implants
    Michael D Diener; Fiscal Year: 2012
    ..RELEVANCE: Joint implants are an effective treatment for those with rheumatoid arthritis, osteoarthritis, osteonecrosis, and other severe destructive injuries;within the U.S...
  35. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2004
    ..of the treatment of hip disease and injury, including total hip arthroplasty, intra-articular fractures, osteonecrosis, and developmental dysplasia...
  36. NONLINEAR COMPUTATIONAL BIOMECHANICS OF THE HIP
    Thomas Brown; Fiscal Year: 2000
    ..of the treatment of hip disease and injury, including total hip arthroplasty, intra-articular fractures, osteonecrosis, and developmental dysplasia...
  37. CELL-CELL COMMUNICATION IN CORTICAL BONE REPAIR
    Frederic Shapiro; Fiscal Year: 1991
    ..repair is of major importance in the management of orthopaedic conditions as diverse as complex fractures, osteonecrosis of the femoral head, and the repair of large defects left by tumor resections, limb lengthenings, or massive ..
  38. The Emu as a Model for Necrotic Femoral Head Collapse
    Thomas Brown; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Femoral head osteonecrosis remains a major unsolved problem in orthopedic surgery of the hip...
  39. Nanocomposite UHMWPE
    MICHAEL DIENER; Fiscal Year: 2009
    ..RELEVANCE: Joint implants are an effective treatment for those with rheumatoid arthritis, osteoarthritis, osteonecrosis, and other severe destructive injuries;within the U.S...
  40. Genome-Wide Association Studies in Sickle Cell Anemia and in Centenarians
    Martin H Steinberg; Fiscal Year: 2010
    ..we will compare associations with clinical features of HbSS including blood pressure, survival, stroke, osteonecrosis, priapism, leg ulcers and an integrated measure of disease severity and also selected laboratory measurements ..
  41. Small molecule compound-based method to induce new bone formation and prevent per
    RICHARD JIN; Fiscal Year: 2007
    ..bone-sparing drugs that are most prescribed in treating osteoporosis, have been linked to the development of osteonecrosis of the jaw (ONJ)...
  42. OSTEONECROSIS AMONG RENAL TRANSPLANT RECIPIENTS
    Kenneth Saag; Fiscal Year: 2001
    ..Afflicting 10-20% of recipients, osteonecrosis [ON] is second only to osteoporosis as the most common post-transplant skeletal complication and usually ..
  43. Bisphosphosphonate-Related Osteonecrosis of the Jaw: A Pilot Pharmacogenetic Stud
    Athanasios Zavras; Fiscal Year: 2008
    ..acid and pamidronate are potent bisphosphonates (BP) that have been associated with increased risk of osteonecrosis of the jaw (ONJ) in cancer patients...
  44. The Role of Osteocyte Survival in Bone Strength
    Robert Weinstein; Fiscal Year: 2005
    ..The proposed research plan will reveal the role of osteocyte survival in bone strength and how osteocytes achieve this objective. ..
  45. Physical Regulation of Skeletal Repair Workshop
    Roy Aaron; Fiscal Year: 2003
    ..Finally, how repairing skeletal tissues organize physical information to augment the repair process, and what translational opportunities exist, will be considered. ..
  46. Mineral and Mechanical Properties of Bone
    Sarandeep Huja; Fiscal Year: 2005
    ..Future interventional studies will examine the mechanisms for the initial and the long-term adaptive response in material properties of bone. ..
  47. Growth Hormone and Rosiglitazone for Visceral Adoposity
    Marshall Glesby; Fiscal Year: 2007
    ..If the results are as predicted, then combination therapy with rhGH and rosiglitazone may prove to be a highly effective treatment for visceral adiposity in HIV-infected patients. ..
  48. Utilizing Saliva to Measure Bone Turnover
    Sreenivas Koka; Fiscal Year: 2007
    ..We anticipate that our results will identify how salivary biomarkers can be used to assess the osseo-status of patients with, or at risk for, osteoporosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Pregnancy Outcomes in Polycystic Ovary Syndrome
    Joan Lo; Fiscal Year: 2009
    ....
  50. RISK FOR ENAMEL FLUOROSIS AMONG NORWEGIAN CHILDREN
    David Pendrys; Fiscal Year: 2003
    ..Caries examination will allow comparison with fluorosis and early fluoride exposures. ..
  51. Determinants of HbF Response to Hydroxyurea
    Martin Steinberg; Fiscal Year: 2005
    ..5 cM resolution. We hope ultimately to discover SNPs, haplotypes or genes that predict or modulate the HbF response to hydroxyurea and better define HbF regulation in sickle cell anemia. ..
  52. BONE AND KNEE LOADING
    Hiroki Yokota; Fiscal Year: 2005
    ..The proposed study will contribute to development of a novel loading model to strengthen bone without causing deformation of fragile bone in the elderly. ..
  53. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
    ..Furthermore, these studies will enhance our basic knowledge as to the role of PTHrP and PTH-1R interactions in controlling mineralized tissue homeostasis. ..
  54. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2005
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  55. Anticancer Agent Pharmacodynamics in Acute Leukemia
    Mary Relling; Fiscal Year: 2006
    ..Our long- term goal is to identify host- and treatment-related risk factors for t-AML so that we can design less leukemogenic anticancer treatment regimens, with improved efficacy for the primary ALL. ..
  56. RAGE, Inflammation and Temporomandibular Joint Disorders
    Regina Landesberg; Fiscal Year: 2006
    ..If successful, these studies will identify new markers for disease activity in TMD, as well as new targets for therapeutic intervention. ..
  57. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
    ..There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Analysis of perlecan in the skeletal system
    Kathryn Rodgers; Fiscal Year: 2006
    ..The ability of perlecan domain I alone to rescue the perlecan null phenotype in cartilage will be addressed using transgenic mice, a project related to the disease dysssegmental dysplasia, Silverman-Handmaker type. ..
  59. Bisphosphonates and Oral Complications of Cancer Chemotherapy: A Pilot Study
    Regina Landesberg; Fiscal Year: 2007
    ..Many, but not all patients had dental extractions or surgical manipulation prior to the development of osteonecrosis (ON)...
  60. GENETIC FACTORS CAUSING LONGEVITY IN CENTENARIANS AND THEIR OFFSPRING
    Clinton Baldwin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..abstract_text> ..
  62. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..