osteoporosis

Summary

Summary: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
  2. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
  3. ncbi An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 17:1726-33. 2006
  4. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
  5. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
  6. pmc Osteoporosis: now and the future
    Tilman D Rachner
    Division of Endocrinology, Diabetes, and Bone Diseases, Dresden Technical University Medical Centre, Dresden, Germany
    Lancet 377:1276-87. 2011
  7. ncbi Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications
    P Lips
    Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Endocr Rev 22:477-501. 2001
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  9. doi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
  10. ncbi The burden of osteoporotic fractures: a method for setting intervention thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 12:417-27. 2001

Detail Information

Articles from Journal RESEARCH1

Publications353 found, 100 shown here

  1. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
    ..Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.
  2. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth...
  3. ncbi An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 17:1726-33. 2006
    ..The aim of this study was to quantify the global burden of osteoporotic fracture worldwide...
  4. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
    ..exhibit medial calcification of the aorta and renal arteries, suggesting that regulation of OPG, its signaling pathway, or its ligand(s) may play a role in the long observed association between osteoporosis and vascular calcification.
  5. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
    ..many common and serious diseases, including some common cancers, type 1 diabetes, cardiovascular disease, and osteoporosis. Numerous epidemiologic studies suggest that exposure to sunlight, which enhances the production of vitamin D(3)..
  6. pmc Osteoporosis: now and the future
    Tilman D Rachner
    Division of Endocrinology, Diabetes, and Bone Diseases, Dresden Technical University Medical Centre, Dresden, Germany
    Lancet 377:1276-87. 2011
    b>Osteoporosis is a common disease characterised by a systemic impairment of bone mass and microarchitecture that results in fragility fractures...
  7. ncbi Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications
    P Lips
    Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Endocr Rev 22:477-501. 2001
    ..Vitamin D3 is recommended in housebound elderly, and it may be cost-effective in hip fracture prevention in selected risk groups...
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    b>Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures...
  9. doi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
    In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites...
  10. ncbi The burden of osteoporotic fractures: a method for setting intervention thresholds
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 12:417-27. 2001
    ..fractures was weighted according to their morbidity using utility values based on those derived by the National Osteoporosis Foundation...
  11. ncbi Therapeutic approaches to bone diseases
    G A Rodan
    Merck Research Laboratories, West Point, PA 19486, USA St Vincent s Institute of Medical Research, Melbourne 3065, Australia
    Science 289:1508-14. 2000
    ..Drugs that inhibit the formation or activity of osteoclasts are valuable for treating osteoporosis, Paget's disease, and inflammation of bone associated with rheumatoid arthritis or periodontal disease...
  12. doi Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Osteoporos Int 21:195-214. 2010
    ..For instance, serum or urine pentosidine levels are now being used to estimate future fracture risk in osteoporosis and diabetes...
  13. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
    Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both women and men, but epidemiological evidence in humans and recent mechanistic studies in rodents indicate that aging and the associated increase in ..
  14. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility...
  15. ncbi Sex steroids and the construction and conservation of the adult skeleton
    B Lawrence Riggs
    Division of Endocrinology and Metabolism, Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocr Rev 23:279-302. 2002
    Here we review and extend a new unitary model for the pathophysiology of involutional osteoporosis that identifies estrogen (E) as the key hormone for maintaining bone mass and E deficiency as the major cause of age-related bone loss in ..
  16. ncbi Diagnosis of osteoporosis and assessment of fracture risk
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Lancet 359:1929-36. 2002
    The diagnosis of osteoporosis centres on the assessment of bone mineral density (BMD). Osteoporosis is defined as a BMD 2.5 SD or more below the average value for premenopausal women (T score < -2.5 SD)...
  17. ncbi Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    b>Osteoporosis and obesity, two disorders of body composition, are growing in prevalence. Interestingly, these diseases share several features including a genetic predisposition and a common progenitor cell...
  18. ncbi Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study
    Dario Maggio
    Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
    J Clin Endocrinol Metab 88:1523-7. 2003
    ..defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress...
  19. doi The effect of vitamin D on bone and osteoporosis
    Paul Lips
    Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 25:585-91. 2011
    ..The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, ..
  20. ncbi Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
    b>Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents...
  21. doi Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking
    Hidetoshi Nojiri
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Bone Miner Res 26:2682-94. 2011
    ..We herein present a valuable model for investigating the effects of oxidative stress on bone fragility in order to develop suitable therapeutic interventions...
  22. pmc Relationship of obesity with osteoporosis
    Lan Juan Zhao
    Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA
    J Clin Endocrinol Metab 92:1640-6. 2007
    The relationship between obesity and osteoporosis has been widely studied, and epidemiological evidence shows that obesity is correlated with increased bone mass...
  23. pmc Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
    Mark J Bolland
    Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
    BMJ 341:c3691. 2010
    ..To investigate whether calcium supplements increase the risk of cardiovascular events...
  24. doi Long-term use of bisphosphonates in osteoporosis
    Nelson B Watts
    University of Cincinnati Bone Health and Osteoporosis Center, Cincinnati, Ohio 45219, USA
    J Clin Endocrinol Metab 95:1555-65. 2010
    Bisphosphonates have been widely used in the treatment of osteoporosis. Uncommon side effects have emerged in postapproval use...
  25. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
    ..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
  26. pmc PPARγ: a circadian transcription factor in adipogenesis and osteogenesis
    Masanobu Kawai
    Center for Clinical and Translational Research, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074 7205, USA
    Nat Rev Endocrinol 6:629-36. 2010
    ....
  27. doi Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women
    Dana Bliuc
    Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    JAMA 301:513-21. 2009
    ..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture...
  28. doi The incidence and residual lifetime risk of osteoporosis-related fractures in Korea
    Chanmi Park
    Health Insurance Review and Assessment Service, 168 Hyoryeong ro, Seocho Gu, Seoul 137 706, South Korea
    J Bone Miner Metab 29:744-51. 2011
    Although the Korean population does not have high risk for osteoporosis, the numbers of osteoporosis-related fractures represent a considerable economic burden to society...
  29. pmc Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA
    Am J Clin Nutr 93:1142-51. 2011
    ..Polyunsaturated fatty acids and fish may influence bone health...
  30. ncbi Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK
    Bone 27:585-90. 2000
    ..hip fracture in men and women using World Health Organization (WHO) diagnostic criteria for low bone mass and osteoporosis. Reference data for bone mineral density (BMD) at the femoral neck, from the third National Health and ..
  31. doi Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk
    Toshitaka Nakamura
    Department of Orthopedic Surgery, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Clin Endocrinol Metab 97:3097-106. 2012
    ..Weekly teriparatide injection at a dose of 56.5 μg has been shown to increase bone mineral density...
  32. ncbi Osteoporosis in patients with diabetes mellitus
    Lorenz C Hofbauer
    Division of Gastroenterology and Endocrinology, Department of Medicine, Philipps University, Marburg, Germany
    J Bone Miner Res 22:1317-28. 2007
    ..physical activity and high-energy food intake contribute to an increasing incidence of diabetes mellitus and osteoporosis. Diabetes mellitus is a risk factor for osteoporotic fractures...
  33. doi Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model
    Thuy Thanh To
    Department of Biological Sciences, National University of Singapore, Singapore 117543
    Development 139:141-50. 2012
    ..osteoclastogenesis are of great interest for investigating the pathology and treatment of bone diseases such as osteoporosis. In mammals, receptor activator of NF-κB ligand (Rankl) is a regulator of osteoclast formation and activation: ..
  34. ncbi Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
    J Justesen
    University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark
    Biogerontology 2:165-71. 2001
    ..characterized by decreased bone formation and bone mass and these changes are more pronounced in patients with osteoporosis. As osteoblasts and adipocytes share a common precursor cell in the bone marrow, we hypothesized that decreased ..
  35. pmc Population genomics in a disease targeted primary cell model
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:1942-52. 2009
    ..5, P = 2.6 x 10(-15)). Our results suggest that primary cells relevant to disease phenotypes complement traditional approaches for prioritization and validation of GWAS hits for follow-up studies...
  36. pmc Denosumab in men receiving androgen-deprivation therapy for prostate cancer
    Matthew R Smith
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 361:745-55. 2009
    ....
  37. ncbi Severely suppressed bone turnover: a potential complication of alendronate therapy
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:1294-301. 2005
    Alendronate, an inhibitor of bone resorption, is widely used in osteoporosis treatment. However, concerns have been raised about potential oversuppression of bone turnover during long-term use...
  38. pmc An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
    Yi Hsiang Hsu
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 6:e1000977. 2010
    b>Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health...
  39. ncbi Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    S C Manolagas
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Endocr Rev 21:115-37. 2000
    ..is essential for the maintenance of bone homeostasis; and that common metabolic bone disorders such as osteoporosis result largely from a derangement in the birth or death of these cells...
  40. doi Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
    R G G Russell
    Nuffield Department of Orthopaedic Surgery, Oxford University Institute of Musculoskeletal Sciences The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Osteoporos Int 19:733-59. 2008
    Bisphosphonates (BPs) are well established as the leading drugs for the treatment of osteoporosis. There is new knowledge about how they work...
  41. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone...
  42. ncbi A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis
    Pooneh Salari
    Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 14:RA37-44. 2008
    b>Osteoporosis, especially in postmenopausal women, delineates a major health and economic problem in the world...
  43. ncbi Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption
    G Zhang
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N T Hong Kong SAR, PR China
    Bone 38:818-25. 2006
    ..our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption.
  44. doi Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
    S Vasikaran
    Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
    Osteoporos Int 22:391-420. 2011
    The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend that a marker of bone formation (serum procollagen type I N propeptide, s-PINP) and a marker ..
  45. pmc The laboratory rat as an animal model for osteoporosis research
    Pavlos P Lelovas
    Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Greece
    Comp Med 58:424-30. 2008
    b>Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial etiology...
  46. doi Interpretation and use of FRAX in clinical practice
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 22:2395-411. 2011
    ..Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review..
  47. pmc Estrogen deficiency and bone loss: an inflammatory tale
    M Neale Weitzmann
    Division of Endocrinology, Metabolism, and Lipids and Molecular Pathogenesis Program, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 116:1186-94. 2006
    ..and cytokines, each apparently capable of playing a relevant role, into a comprehensive model of postmenopausal osteoporosis. This Review presents our current understanding of the process of estrogen deficiency-mediated bone destruction ..
  48. pmc Exposure to oral bisphosphonates and risk of esophageal cancer
    Chris R Cardwell
    Centre for Public Health, Queen s University Belfast, Grosvenor Rd, Belfast BT12 6BJ, United Kingdom
    JAMA 304:657-63. 2010
    ..Esophagitis is a known adverse effect of bisphosphonate use, and recent reports suggest a link between bisphosphonate use and esophageal cancer, but this has not been robustly investigated...
  49. pmc 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada
    Jacques P Brown
    Division of Rheumatology, Centre de Recherche du CHUL, Universite Laval, Canada
    CMAJ 167:S1-34. 2002
    To revise and expand the 1996 Osteoporosis Society of Canada clinical practice guidelines for the management of osteoporosis, incorporating recent advances in diagnosis, prevention and management of osteoporosis, and to identify and ..
  50. pmc A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
    Hui Li
    Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, Changsha, Hunan, People s Republic of China
    J Clin Invest 119:3666-77. 2009
    ..and a homozygous mutation in pre-miR-2861 that blocked expression of miR-2861 was shown to cause primary osteoporosis in 2 related adolescents...
  51. ncbi Vascular calcification: mechanisms and clinical ramifications
    Moeen Abedin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1161-70. 2004
    ..Vascular calcification is exacerbated in certain clinical entities, including diabetes, menopause, and osteoporosis. Mechanisms linking them must be considered in clinical decisions...
  52. doi Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    ..Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis.
  53. pmc Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
    A Wesselius
    Department of Epidemiology, School for Public Health and Primary Care CAPHRI, Maastricht University, Peter Debyeplein 1, P O Box 616, 6200, MD, Maastricht, The Netherlands
    Osteoporos Int 24:1235-46. 2013
    ..We found an association between four non-synonymous polymorphism of the human P2X7 receptor and the risk of osteoporosis.
  54. doi Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women
    Annette Engström
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Bone 50:1372-8. 2012
    b>Osteoporosis and its main health outcome, fragility fractures, are large and escalating public health problems...
  55. doi Osteoporosis in men: an Endocrine Society clinical practice guideline
    Nelson B Watts
    Mercy Health Osteoporosis and Bone Health Services, Cincinnati Ohio 45236, USA
    J Clin Endocrinol Metab 97:1802-22. 2012
    The aim was to formulate practice guidelines for management of osteoporosis in men.
  56. doi Benefits and risks of bisphosphonate therapy for osteoporosis
    Sundeep Khosla
    College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 97:2272-82. 2012
    ..the risks of bisphosphonates for the treatment of osteoporosis. Risks include possible associations with osteonecrosis of the jaw (ONJ) and atypical femur fractures...
  57. pmc Glucocorticoid-induced osteoporosis and osteonecrosis
    Robert S Weinstein
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, and Central Arkansas Veterans Healthcare System at the University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 587, Little Rock, AR 72205 7199, USA
    Endocrinol Metab Clin North Am 41:595-611. 2012
    Glucocorticoid administration is the most common cause of secondary osteoporosis and the leading cause of nontraumatic osteonecrosis...
  58. ncbi Epidemiology, etiology, and diagnosis of osteoporosis
    Nancy E Lane
    Aging Center, Medicine and Rheumatology, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Am J Obstet Gynecol 194:S3-11. 2006
    b>Osteoporosis, a major public health problem, is becoming increasingly prevalent with the aging of the world population...
  59. doi Osteoblasts in osteoporosis: past, emerging, and future anabolic targets
    Pierre J Marie
    Laboratory of Osteoblast Biology and Pathology, INSERM, U606, Hospital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Eur J Endocrinol 165:1-10. 2011
    ..The current challenge is to promote osteoblastogenesis and bone formation to prevent age-related bone deterioration...
  60. pmc Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG
    Grace A McComsey
    Departments of Pediatrics and Medicine, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 203:1791-801. 2011
    ..Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz (EFV) or atazanavir plus ritonavir (ATV/r), on bone mineral density (BMD) have not been analyzed...
  61. ncbi Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use
    Anthony B Hodsman
    University of Western Ontario, St Joseph s Health Care, Room 2F 15, 268, Grosvenor Street, London, Ontario N6A 4V2, Canada
    Endocr Rev 26:688-703. 2005
    All therapies currently recommended for the management of osteoporosis act mainly to inhibit bone resorption and reduce bone remodeling...
  62. pmc Cost-effective osteoporosis treatment thresholds: the United States perspective
    A N A Tosteson
    Multidisciplinary Clinical Research Center in Musculoskeletal Diseases and The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, NH 03756, USA
    Osteoporos Int 19:437-47. 2008
    ..rib, pelvis and lower leg, was undertaken to identify the 10-year hip fracture probability required for osteoporosis treatment to be cost-effective for cohorts defined by age, sex, and race/ethnicity...
  63. ncbi Requirements for DXA for the management of osteoporosis in Europe
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:229-38. 2005
    ..aim of this study was to estimate the requirements for DXA in Europe for the assessment and treatment of osteoporosis. Three assessment scenarios were chosen...
  64. ncbi Association between oxidative stress and bone mineral density
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 25 Uppsala, Sweden
    Biochem Biophys Res Commun 288:275-9. 2001
    ..Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis.
  65. doi The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis
    Sebastio Perrini
    Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    J Endocrinol 205:201-10. 2010
    ..This article will focus on the molecular mechanisms of impaired GH and IGF1 signaling and action in aging, and their role in the pathogenesis of sarcopenia and osteoporosis.
  66. doi Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur
    Dennis M Black
    University of California at San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 362:1761-71. 2010
    ..A population-based study did not support this association. Such a relationship has not been examined in randomized trials...
  67. doi Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification
    Mariana Kiomy Osako
    Division of Clinical Gene Therapy, Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Japan
    Circ Res 107:466-75. 2010
    Arterial calcification and osteoporosis are associated in postmenopausal women...
  68. ncbi Mortality after osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 15:38-42. 2004
    ..The decreasing mortality with time after fracture may be due in part to a decrease in deaths causally related to the fracture. The extent to which early intervention for osteoporosis might avoid some of these deaths is unknown.
  69. pmc Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
    H Min
    Department of Biosystems Analysis, Amgen, Incorporated, Thousand Oaks, California 91320, USA
    J Exp Med 192:463-74. 2000
    ..Such findings may also explain the observed high clinical incidence of vascular calcification in the osteoporotic patient population...
  70. ncbi Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:18-28. 2006
    ..The implications of higher doses for the entire adult population should be addressed in future studies...
  71. doi Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis
    Latha Devareddy
    Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA
    J Nutr Biochem 19:694-9. 2008
    ..In summary, our findings indicate that blueberry can prevent bone loss as seen by the increases in BMD and favorable changes in biomarkers of bone metabolism...
  72. doi Genetics of osteoporosis
    Stuart H Ralston
    Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocr Rev 31:629-62. 2010
    b>Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of fragility fractures...
  73. doi Denosumab and bisphosphonates: different mechanisms of action and effects
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Bone 48:677-92. 2011
    To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb bone...
  74. pmc Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice
    Susann Helas
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University of Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Am J Pathol 175:473-8. 2009
    b>Osteoporosis and vascular calcification frequently coincide...
  75. pmc Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture
    J Brent Richards
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 151:528-37. 2009
    b>Osteoporosis is a highly heritable trait. Many candidate genes have been proposed as being involved in regulating bone mineral density (BMD). Few of these findings have been replicated in independent studies.
  76. pmc Building bone to reverse osteoporosis and repair fractures
    Sundeep Khosla
    Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Invest 118:421-8. 2008
    ..important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass...
  77. ncbi Osteoporosis and inflammation
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    Nutr Rev 65:S147-51. 2007
    b>Osteoporosis represents a major healthcare burden, affecting approximately 10 million people aged over 50 years in the United States and with another 30 million or more at risk...
  78. ncbi New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures
    S R Garfin
    University of California, San Diego, California, USA
    Spine (Phila Pa 1976) 26:1511-5. 2001
    ..Literature review...
  79. doi Angiotensin II accelerates osteoporosis by activating osteoclasts
    Hideo Shimizu
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 22:2465-75. 2008
    ..To clarify the relationship between hypertension and osteoporosis, we focused on the role of angiotensin II (Ang II) on bone metabolism...
  80. ncbi Osteoporosis in children and adolescents
    Maria Luisa Bianchi
    Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS Via L Ariosto 13 20145, Milano, Italy
    Bone 41:486-95. 2007
    ..The classical definition of osteoporosis should be valid at any age, yet its practical applicability to children and adolescents remains a matter of ..
  81. doi Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK
    J Compston
    University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge, United Kingdom
    Maturitas 62:105-8. 2009
    In 1999 and 2000 the Royal College of Physicians published guidelines for the prevention and treatment of osteoporosis [Royal College of Physicians. Osteoporosis: clinical guidelines for the prevention and treatment...
  82. pmc Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis
    Tie Lin Yang
    Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, People s Republic of China
    Am J Hum Genet 83:663-74. 2008
    b>Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral density (BMD), poor bone geometry, and/or osteoporotic fractures (OF)...
  83. ncbi Expression of bone resorption genes in osteoarthritis and in osteoporosis
    Darja Bitenc Logar
    Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000, Ljubljana, Slovenia
    J Bone Miner Metab 25:219-25. 2007
    ....
  84. pmc Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study
    George Ioannidis
    Department of Medicine, McMaster University, Hamilton, Ont
    CMAJ 181:265-71. 2009
    ..Fractures have largely been assessed by their impact on quality of life or health care costs. We conducted this study to evaluate the relation between fractures and mortality...
  85. pmc A randomized trial of vertebroplasty for osteoporotic spinal fractures
    David F Kallmes
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    N Engl J Med 361:569-79. 2009
    ..Vertebroplasty is commonly used to treat painful, osteoporotic vertebral compression fractures...
  86. ncbi Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
    T Xu
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:78-82. 1998
    ..These mice may serve as an animal model to study the role of ECM proteins in osteoporosis.
  87. ncbi The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report
    S Boonen
    Leuven University Centre for Metabolic Bone Diseases and Division of Geriatric Medicine, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Osteoporos Int 15:511-9. 2004
    ..Its implications for the use of oral supplements of calcium and vitamin D in the prevention and treatment of osteoporosis were discussed at a meeting organized with the help of the World Health Organization (WHO) Collaborating Center ..
  88. ncbi Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats
    Sridhar Muthusami
    Department of Endocrinology, Dr ALMPGIBMS, University of Madras, Taramani, Chennai, 600 113, India
    Clin Chim Acta 360:81-6. 2005
    ..Ovariectomized rats have been used as the animal model for the study of osteoporosis. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells...
  89. doi Osteoporosis: an age-related and gender-specific disease--a mini-review
    Peter Pietschmann
    Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Gerontology 55:3-12. 2009
    b>Osteoporosis, a classical age-related disease and known to be more common in women than in men, has been reported increasingly often in men during the past few years...
  90. doi Osteoporosis: impact on health and economics
    Nicholas Harvey
    The MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Nat Rev Rheumatol 6:99-105. 2010
    b>Osteoporosis is a major public health problem through associated fragility fractures. The most common sites of fracture are the hip, spine and wrist, and these have an enormous health and economic impact...
  91. pmc Advances in glucocorticoid-induced osteoporosis
    Debby den Uyl
    Department of Rheumatology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Curr Rheumatol Rep 13:233-40. 2011
    Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures...
  92. pmc Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies
    Annie W C Kung
    Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Am J Hum Genet 86:229-39. 2010
    Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor of fracture, is a polygenic trait with high heritability...
  93. ncbi The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosis
    Rachel Halpern
    Health Economics and Outcomes Research, i3 Innovus, 12125 Technology Dr, MN002 0258, Eden Prairie, MN 55344, USA
    J Manag Care Pharm 17:25-39. 2011
    b>Osteoporosis affects approximately 10 million people in the United States and is associated with increased fracture risk and fracture-related costs...
  94. pmc Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:311-25. 2012
    b>Osteoporosis is defined as low bone mineral density associated with skeletal fractures secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm...
  95. doi The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study
    A Papaioannou
    McMaster University, Hamilton Health Sciences Chedoke Site, Hamilton, ON, Canada
    Osteoporos Int 20:703-14. 2009
    Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical ..
  96. pmc Bone-density testing interval and transition to osteoporosis in older women
    Margaret L Gourlay
    Department of Family Medicine, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 7595, USA
    N Engl J Med 366:225-33. 2012
    Although bone mineral density (BMD) testing to screen for osteoporosis (BMD T score, -2.50 or lower) is recommended for women 65 years of age or older, there are few data to guide decisions about the interval between BMD tests.
  97. pmc Defining ethnic and racial differences in osteoporosis and fragility fractures
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree A543, Pittsburgh, PA 15261, USA
    Clin Orthop Relat Res 469:1891-9. 2011
    ..Osteoporotic fractures are a major public health issue. The literature suggests there are variations in occurrence of fractures by ethnicity and race...
  98. pmc Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
    Dallas Jones
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 121:2534-42. 2011
    ..and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.
  99. doi The societal burden of osteoporosis
    David J Becker
    Department of Health Care Organization and Policy, University of Alabama at Birmingham School of Public Health, RPHB 330, 1530 3rd Avenue South, Birmingham, AL 35294 0022, USA
    Curr Rheumatol Rep 12:186-91. 2010
    b>Osteoporosis currently affects 10 million Americans and is responsible for more than 1.5 million fractures annually...
  100. doi Soy isoflavones for osteoporosis: an evidence-based approach
    Kyoko Taku
    Section of Biostatistical Research, Center for International Collaboration and Partnership, National Institute of Health and Nutrition, Tokyo, Japan
    Maturitas 70:333-8. 2011
    Effects of soy isoflavones on osteoporosis remain unclear. This review aimed to clarify the effect of soy isoflavones on bone mineral density (BMD) and turnover markers in menopausal women...
  101. pmc Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report
    R Rizzoli
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospitals and Faculty of Medicine of Geneva, 1211, Geneva 14, Switzerland
    Osteoporos Int 22:373-90. 2011
    ..Bisphosphonate use may be associated with atypical subtrochanteric fractures, but the case is yet unproven...

Research Grants71

  1. Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
    Martin A Freilich; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Osteoporosis is a major public health issue in our aging population, affecting 44 million Americans...
  2. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone fractures resulting from osteoporosis lead to significant health costs, morbidity, loss of mobility, and often mortality in aged individuals...
  3. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..study is ongoing and will investigate the effect of chitosan administered in dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D ..
  4. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..study is ongoing and will investigate the effect of chitosan administered in dosed feed on bone osteopenia and osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D ..
  5. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The study includes 660 postmenopausal women enrolled in a periodontal disease/osteoporosis study at the Buffalo (NY) center of the Women's Health Initiative...
  6. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..diseases, including coronary heart disease, diabetes, arthritis, obesity, macular degeneration, dry eye, osteoporosis, Alzheimer's disease and mental health disorders, and there is evidence from clinical and experimental ..
  7. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..metabolic disorders associated with aberrant ovarian steroid secretion are hypertension, diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and uterus...
  8. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Widespread bone disorders including osteoporosis, arthritis, periodontal bone disease, joint replacement loosening, and tumor metastasis to bone, all have in ..
  9. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..important implications for women who commonly suffer from the morbid and sometimes mortal complications of both osteoporosis and cardiovascular disease risk factor clustering, metabolic syndrome...
  10. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..modalities aimed at restoring FOXO deacetylation and phosphorylation may form the basis for a novel approach to osteoporosis therapy. PUBLIC HEALTH RELEVANCE...
  11. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes.
  12. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..with autosomal dominant premature coronary artery disease (CAD), diabetes hyperlipidemia, hypertension, and osteoporosis we have identified the disease causing mutations that substitute evolutionarily highly conservative amino acids ..
  13. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Identification of Proteins Important for Male Osteoporosis Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD)...
  14. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..increase in oxidative stress, constitute the physiological and molecular consequences of hormone deficiency and osteoporosis. Accelerated senescence syndromes caused by accumulation of unprocessed farnesylated nuclear lamina protein ..
  15. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  16. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..transgenic mice, indicating that Runx2 must be restrained in order to keep bone turnover in check and prevent osteoporosis. We therefore propose to investigate in depth the physical interactions between Runx proteins and SHRs, the ..
  17. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..No prophylactic treatment exists for radiation therapy-induced osteoporosis, and molecular mechanisms for this rapid loss of bone mass and strength and resultant increased fracture risk ..
  18. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..4 million) binge drink. A resulting reduction in peak bone mass would predispose women to osteoporosis in later life. The molecular mechanisms underlying the toxic effects of EtOH on bone remain poorly understood...
  19. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..This is of critical concern given the tremendous impact of osteoporosis and fracture in both men and women...
  20. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..of circulating androgens (testosterone and dehydroepiandrosterone (DHEA)), which has been linked to sarcopenia, osteoporosis, cardiovascular disease and diabetes...
  21. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012
    ..for prostate cancer because: 1) Cathepsin K inhibitors are currently in clinical trials for treatment of osteoporosis. Validating a causal rolefor this enzyme in metastasis of prostate tumors to the bone could be rapidly ..
  22. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..a balanced rate;any imbalance between the two rates results in varying states of abnormal bone turnover such as osteoporosis, with accompanying bone fragility and increased risk of fracture...
  23. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..patients with excess bone resorption and, as such, PTP-oc could be a target for pharmacogenomic treatments of osteoporosis and related bone-wasting diseases...
  24. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..challenges include cardiovascular diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
  25. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoporosis is a major public health threat in the U.S. today affecting at least 44 million Americans and up to 55% of people over 50 years of age...
  26. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..for managing secondary hyperparathyroidism in chronic kidney disease, and to a lesser degree used to treat osteoporosis and psoriasis...
  27. Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
    Xing Ming Shi; Fiscal Year: 2012
    Research Goals and Significance: Osteoporosis and obesity are major public health threats in the US. However, the underlying mechanisms, and whether these seemingly unrelated diseases have a common element, are unknown...
  28. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..Both mice develop age-related pathologies including ataxia, kyphosis, cachexia, disc degeneration, osteoporosis, incontinence, epidermal atrophy, sarcopenia, bone marrow degeneration and liver as well as kidney dysfunction...
  29. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..bone cell populations as a means to treat disorders of low bone formation and excessive remodeling such as osteoporosis, hyperparathyroidism, and bone metastases...
  30. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..Importantly, these studies will shed new light on the ErbB and Dock7 signaling pathways in bone and in BAT. Defining shared metabolic-skeletal networks may lead to new treatments for age-related osteoporosis.
  31. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2013
    ..While it is assumed that most fragility fractures are caused by osteoporosis, where the mineral composition of the bone tissue is normal, but the volume of bone tissue is decreased;50% of ..
  32. Optimizing Chronic Disease Prevention and Management in Advanced Dementia
    Jennifer Tjia; Fiscal Year: 2010
    ..These agents such as lipid-lowering and osteoporosis drugs may not be consistent with goals of care, increase the risk of adverse drug events and drug-drug ..
  33. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  34. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..causes bone destruction as observed in diseases such as autoimmune arthritis, periodontosis, postmenopausal osteoporosis, Padget's disease and bone tumor metastasis...
  35. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    ..While it is assumed that most fragility fractures are caused by osteoporosis, where the mineral composition of the bone tissue is normal, but the volume of bone tissue is decreased;50% of ..
  36. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    ..Both mouse models indicate that restraining the activity of Runx2 helps keep bone turnover in check and prevent osteoporosis. We therefore propose to investigate in depth the physical interactions between Runx proteins and SHRs, the ..
  37. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..what is observed in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  38. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..and it is not known whether vitamin D can prevent or reverse the structural deterioration characteristic of osteoporosis. Recent advances in bone imaging make it possible to assess volumetric BMD (vBMD), structure, and micro- ..
  39. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..2 Furthermore, the VA identified arthritis, pain, obesity, and osteoporosis as priority conditions in women;each of these is addressed in this application...
  40. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Idiopathic osteoporosis (IOP) affects otherwise healthy young men and women with intact gonadal function and no secondary cause of bone loss...
  41. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..This proposal is also directly relevant to Challenge Topic 15-AR-105 Bone and Adipose Tissue. Osteoporosis and obesity are growing sources of morbidity and mortality in the US, and together impose healthcare costs of ..
  42. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoporosis is a major public health threat...
  43. cGMP-dependent Protein Kinase Function in Osteoblast Mechanotransduction
    Renate B Pilz; Fiscal Year: 2013
    ..studies will provide new insights into NO/cGMP/PKG actions in bone, and could lead to improved therapies for osteoporosis. PUBLIC HEALTH RELEVANCE: Mechanical stimulation is a potent stimulus for bone cell (osteoblast) growth and ..
  44. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Osteoporosis is a public health problem that affects approximately 25 million people in the United States...
  45. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2013
    ..to contribute to several different human diseases, including leukemia, social behavior defects, diabetes, and osteoporosis. Understanding the roles CD38 plays in various normal and pathological conditions has the potential to offer ..
  46. Underserved Men's Understanding of Androgen Deprivation Therapy Related Risks
    Sally L Maliski; Fiscal Year: 2012
    ..and decreased arterial compliance all of which places them at higher risk for cardiovascular disease (CVD), osteoporosis, and type II diabetes...
  47. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..The ratio of symptomatic to asymptomatic CD is estimated to be 1:7. Some complications of CD include lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune diseases...
  48. STRUCTURE OF THE VACUOLAR ATPase
    Stephan Wilkens; Fiscal Year: 2013
    ..ATPase have been associated with a number of diseases such as renal tubular acidosis, sensorineural deafness, osteoporosis, diabetes and cancer...
  49. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..for early-stage, HR-positive breast cancer, we will investigate the risk of fractures (primary outcome) and osteoporosis (secondary outcome) in association with 1) modifiable lifestyle factors such as physical activity, diet, ..
  50. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..pressing public health problems for the aging population is the increasing fragility and brittleness of bones, osteoporosis;brittle and de-mineralized bones are much more susceptible to fractures which are a major problem for the ..
  51. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..Arthritis, diabetes, heart disease, hypertension, low back pain, obesity, osteoporosis, and other common conditions are the result of or result in reduced activity level and diminished quality of ..
  52. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Elucidating childhood precursors of osteoporosis may lead to interventions that prevent or mitigate osteoporosis later in life...
  53. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): 1. Osteoporosis is "a pediatric disease with geriatric consequences". Simply stated, suboptimal skeletal. 2...
  54. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..to natural estrogens, environmental estrogen-like compounds, and drugs used for treatment of breast cancer and osteoporosis. We seek to understand how estrogens control the development and function of key regulatory cells of the immune ..
  55. Ligand Interaction of Glucagon Receptor by Structural and Functional Analyses
    FAI YIU SIU; Fiscal Year: 2012
    ..receptors (GPCRs) recognize hormone peptides that are critical to pathological conditions such as diabetes, osteoporosis, cancer, obesity, and neurological disorders, including depression and anxiety...
  56. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    ..hormone function are associated with pathological conditions of bone development and remodeling including osteoporosis and it is possible that chronic PBDE exposure may be detrimental to bone health...
  57. Role of Gsalpha in Regulating Osteoblast Differentiation
    JOY Y WU; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Osteoporosis is an extremely common degenerative disease resulting from an imbalance between bone formation and bone resorption...
  58. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..Abnormal OCL number and/or activity result in a number of bone diseases such as osteoporosis, Paget's disease of bone, metastatic osteolytic lesions, and rheumatoid arthritis...
  59. Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte d
    Partha S Sinha; Fiscal Year: 2011
    ..and osteoblasts may carry implications for metabolic diseases such as obesity and of bone diseases such as osteoporosis. Our studies focus on the potential role in this mechanism of Gsa, a heterotrimeric G protein subunit that ..
  60. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..Vitamin D (VD) is a widely and chronically used supplement for maintenance of bone health and for treatment of osteoporosis, but a growing body of evidence has indicated that VD has potent chemopreventive effects against colon cancer ..
  61. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
    ..and frozen samples from two funded and completed federally supported studies investigating the association of osteoporosis and periodontal disease (DOD #OS950077;R01DE013505)...
  62. Klotho regulation and aging
    GWENDALYN DIANN KING; Fiscal Year: 2013
    ..what is observed in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  63. The role of caspase-2 in osteoblast-osteoclast interactions
    DANIELLE ARDEN VICTOR; Fiscal Year: 2013
    ..goal of this study is to elucidate the role of the apoptosis-related protease, caspase-2, in male age-dependent osteoporosis. Our lab has demonstrated that mice deficient in caspase-2 not only have decreased maximum life span, but also ..
  64. Combining Imaging and Modeling in Osteoporosis Fracture Risk Assessment
    GARY BEAUPRE; Fiscal Year: 2009
    6. Project Summary/Abstract Osteoporosis is a major and growing US heath concern. The National Osteoporosis Foundation estimates that 44 million Americans have osteoporosis or low bone mass...
  65. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    b>Osteoporosis is a major cause of morbidity and mortality in postmenopausal women. In an United States,, an estimated 13% to 18% of women have osteoporosis...
  66. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    b>Osteoporosis is a major cause of morbidity and mortality in postmenopausal women. In an United States,, an estimated 13% to 18% of women have osteoporosis...
  67. OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN
    Michael Nevitt; Fiscal Year: 1992
    ..Yet, there is little data about risk factors for and consequences of the disease in older women. Osteoporosis is also very common, and studies suggest there is an inverse association between the risk of osteoarthritis and ..
  68. Novel therapy for osteoporosis
    Emma Moore; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-term goal of our research is to develop a novel treatment for osteoporosis that will stimulate bone formation...
  69. Synergistic effects of conjugated linoleic acid and calcium on bone mass
    Yeonhwa Park; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): One of the most important interventions for osteoporosis is prevention of bone loss...
  70. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
    ..Celiac disease is associated with the malabsorption of calcium and vitamin D resulting in osteoporosis. Although the prevalence of osteoporosis in the population of patients with celiac disease is known to be ..
  71. 8th International Symposium on Osteoporosis: Translating Research into Clinical P
    Deborah Gold; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The 8th International Symposium on Osteoporosis: Translating Research into Clinical Practice will be held April 2-5, 2009 in Washington DC at the Marriott Wardman Park Hotel...