osteolysis

Summary

Summary: Dissolution of bone that particularly involves the removal or loss of calcium.

Top Publications

  1. ncbi Mechanisms of bone metastasis
    G David Roodman
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, School of Medicine Hematology, The University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    N Engl J Med 350:1655-64. 2004
  2. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
  3. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
  4. ncbi The role of macrophages in osteolysis of total joint replacement
    Eileen Ingham
    School of Biochemistry and Molecular Biology, Institute of Medical and Biological Engineering, Division of Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biomaterials 26:1271-86. 2005
  5. ncbi In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
  6. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
  7. ncbi Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy
    Wende Kozlow
    Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, 22908, USA
    J Mammary Gland Biol Neoplasia 10:169-80. 2005
  8. doi Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival
    Gaëlle Picarda
    Institut National de la Sante et de la Recherche Medicale UMR_S 957, Université de Nantes EA 3822, Nantes Atlantique Universites, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Nantes, France
    Clin Cancer Res 16:2363-74. 2010
  9. ncbi The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis
    D R Haynes
    Department of Pathology, University of Adelaide, South Australia, Australia
    J Bone Joint Surg Br 83:902-11. 2001
  10. ncbi Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma
    Ulrike Heider
    Department of Oncology and Hematology, Universitatsklinikum Charite, Berlin 10098, Germany
    Clin Cancer Res 9:1436-40. 2003

Research Grants

  1. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
  2. Francis Young In Lee; Fiscal Year: 2016
  3. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
  4. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
  5. Yousef Abu-Amer; Fiscal Year: 2016
  6. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
  7. Urszula T Iwaniec; Fiscal Year: 2015
  8. KATHERINE NELSON WEILBAECHER; Fiscal Year: 2014
  9. Lionel B Ivashkiv; Fiscal Year: 2016
  10. Nadim James Hallab; Fiscal Year: 2016

Detail Information

Publications359 found, 100 shown here

  1. ncbi Mechanisms of bone metastasis
    G David Roodman
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, School of Medicine Hematology, The University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    N Engl J Med 350:1655-64. 2004
  2. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  3. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..NF-kappaB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. We found that this process was abolished by IL-1 receptor antagonist (IL-1Ra) or in stromal cells derived from ..
  4. ncbi The role of macrophages in osteolysis of total joint replacement
    Eileen Ingham
    School of Biochemistry and Molecular Biology, Institute of Medical and Biological Engineering, Division of Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biomaterials 26:1271-86. 2005
    The osteolysis associated with conventional polyethylene on metal total joint replacements is associated with the formation of an inflamed periprosthetic membrane rich in macrophages, cytokines and implant-derived wear particles...
  5. ncbi In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    Prosthesis failure due to wear debris-induced osteolysis remains a major clinical problem and the greatest limitation for total joint arthroplasty...
  6. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
    TNF-alpha is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine's ..
  7. ncbi Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy
    Wende Kozlow
    Division of Endocrinology, Department of Medicine, University of Virginia, Charlottesville, 22908, USA
    J Mammary Gland Biol Neoplasia 10:169-80. 2005
    ..These factors and their roles in fueling the vicious cycle may identify novel targets for therapies to prevent metastasis...
  8. doi Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival
    Gaëlle Picarda
    Institut National de la Sante et de la Recherche Medicale UMR_S 957, Université de Nantes EA 3822, Nantes Atlantique Universites, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Nantes, France
    Clin Cancer Res 16:2363-74. 2010
    ....
  9. ncbi The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis
    D R Haynes
    Department of Pathology, University of Adelaide, South Australia, Australia
    J Bone Joint Surg Br 83:902-11. 2001
    Extensive osteolysis adjacent to implants is often associated with wear particles of prosthetic material...
  10. ncbi Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma
    Ulrike Heider
    Department of Oncology and Hematology, Universitatsklinikum Charite, Berlin 10098, Germany
    Clin Cancer Res 9:1436-40. 2003
    ..We found that human myeloma cells express RANKL and analyzed the association of the RANKL expression with the presence of osteolytic bone disease in patients with multiple myeloma...
  11. ncbi Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity?
    Joshua J Jacobs
    J Bone Joint Surg Am 88:1171-2. 2006
  12. doi Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model
    Xiaoxiao Zhou
    Department of Orthopaedics, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People s Republic of China
    J Orthop Res 28:451-6. 2010
    ..Using a titanium particle-induced calvarial osteolysis model in diabetic mice, we investigated the effect of diabetes on the osteolytic process and the role of ..
  13. pmc Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
    Sonia Vallet
    Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:5124-9. 2010
    ..amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased bone marrow plasma activin A levels were found in MM patients with osteolytic disease...
  14. pmc A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes
    Marci D Jones
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Cancer Res 16:4978-89. 2010
    ..Bortezomib, a proteasome inhibitor used for the treatment of multiple myeloma, also promotes bone formation. We tested the hypothesis that proteasome inhibitors can ameliorate BrCa osteolytic disease...
  15. pmc The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cancer Ther 9:3210-20. 2010
    ..Tumor growth in bone was reduced ∼33% by vorinostat with inhibited osteolysis in the first few weeks of the experiment...
  16. doi Current concepts in osteolysis
    B Ollivere
    Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK
    J Bone Joint Surg Br 94:10-5. 2012
    ..frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris...
  17. doi Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation
    Lyndsey Burton
    Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    J Orthop Res 31:73-80. 2013
    Activation of myeloid cells by orthopedic particulate debris is a key event in the pathogenesis of periprosthetic osteolysis and implant loosening after total joint replacement (TJR)...
  18. doi DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma
    Kristina Hauer
    Children s Cancer Research Center and Department of Pediatrics, Roman Herzog Comprehensive Cancer Research Center and Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Res 73:967-77. 2013
    ..are associated with homing, invasion, and growth of cancer cells in bone tissue as well as genes important for osteolysis, including HIF1α, JAG1, IL6, and VEGF...
  19. ncbi Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
    Theresa A Guise
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22903, USA
    Clin Cancer Res 12:6213s-6216s. 2006
    Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation...
  20. doi Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients
    S Colucci
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Leukemia 23:2139-46. 2009
    ..The production of DcR3 by T lymphocytes confers these cells a role in the pathogenesis of bone disease associated with MM...
  21. doi Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: a preliminary study
    F Mrazek
    Laboratory of Immunogenomics and Immunoproteomics, Medical Faculty of Palacky University and University Hospital, Olomouc, Czech Republic
    Hum Immunol 71:201-5. 2010
    Periprosthetic osteolysis (OL) is a major long-term complication of the total hip arthroplasty (THA), which can result in aseptic loosening and revision surgery...
  22. ncbi A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden
    Céline Le Gall
    Institut National de la Sante et de la Recherche Medicale, UMR 664, IFR62, Lyon, France
    Cancer Res 67:9894-902. 2007
    ..Thus, CKI may render the bone a less favorable microenvironment for tumor growth by inhibiting bone resorption. These findings raise the possibility that cathepsin K could be a therapeutic target for the treatment of bone metastases...
  23. pmc Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model
    S M Eck
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH, USA
    Breast Cancer Res Treat 116:79-90. 2009
    ..Tumors expressing MMP-1 were also associated with osteolysis in vivo, whereas tumors with inhibited MMP-1 levels were not...
  24. ncbi Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma
    Masahiro Abe
    First Department of Internal Medicine, School of Medicine, Department of Orthodontics, School of Dentistry, University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Blood 100:2195-202. 2002
    ..a role of C-C chemokines, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, in MM cell-induced osteolysis. These chemokines were produced and secreted by a majority of MM cell lines as well as primary MM cells from ..
  25. ncbi Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:596-607. 2006
    ..the amount of bone resorbed exceeds that being formed, resulting in net bone loss (inflammation-induced osteolysis)...
  26. doi Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma
    Deborah J Heath
    Academic Unit of Bone Biology, Section of Musculoskeletal Sciences, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, Yorkshire, UK
    J Bone Miner Res 24:425-36. 2009
    ....
  27. doi Metal-on-metal hip resurfacing arthroplasty: a review of periprosthetic biological reactions
    Guillaume Mabilleau
    Nuffield Department of Orthopaedic Surgery, Institute of Musculoskeletal Science, Botnar Research Centre, University of Oxford, Oxford, UK
    Acta Orthop 79:734-47. 2008
    ..The purpose of this review is to provide an overview of the current literature on the adverse periprosthetic biological reactions associated with metal-on-metal hip resurfacing arthroplasty...
  28. pmc Osteocyte remodeling of the perilacunar and pericanalicular matrix
    Hai Qing
    Department of Oral Biology, University of Missouri Kansas City, Kansas City 64108, USA
    Int J Oral Sci 1:59-65. 2009
    ..Special attention was paid to how the negative researchers argue about the "osteocytic osteolysis" principle, and how the positive side addressed the arguments...
  29. doi The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles
    Katrin Lochner
    Department of Orthopaedics, University of Rostock, D 18057 Rostock, Germany
    Int J Mol Med 28:1055-63. 2011
    Aseptic loosening in total hip replacement is mainly caused by wear particles inducing inflammation and osteolysis. Wear can be a consequence of micromotions at the interface between implant and bone cement...
  30. ncbi Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    Amanda N Farrugia
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Cancer Res 63:5438-45. 2003
    ..that RANKL expression by MPC confers on them the ability to participate directly in the formation of osteoclast in vivo and extends our knowledge of the involvement of RANKL and OPG in the osteolysis characteristic of this disease.
  31. pmc Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis
    Sophie Thiolloy
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 69:6747-55. 2009
    ..Our data show that osteoclast-derived MMP-7 significantly contributes to tumor growth and tumor-induced osteolysis whereas osteoclast-derived MMP-9 had no effect on these processes...
  32. ncbi Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
    J A Martignetti
    Department of Human Genetics, Mount Sinai School of Medicine, Box 1498, Fifth Avenue at 100th Street, New York, New York, USA
    Nat Genet 28:261-5. 2001
    ..We recently described an autosomal recessive form of multicentric osteolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar ..
  33. ncbi Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation
    Y Bi
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio 44106-5000, USA
    J Bone Miner Res 16:2082-91. 2001
    ..In vivo experiments showed that endotoxin removal reduced particle-induced osteolysis by 50-70%...
  34. ncbi Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis
    L M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 83:1789-97. 2001
    ..gene delivery of a soluble inhibitor of tumor necrosis factor-alpha (sTNFR:Fc) could prevent wear debris-induced osteolysis in a mouse model...
  35. ncbi A possible role of VEGF in osteolytic bone metastasis of hepatocellular carcinoma
    H Iguchi
    Division of Biochemistry, National Kyushu Cancer Center Research Institute, Fukuoka, Japan
    J Exp Clin Cancer Res 21:309-13. 2002
    ..VEGF may also facilitate tumor growth in the bone by acting as an angiogenic factor once invasion of the bone is complete. This might be another reason for the high incidence of bone metastasis in HCC...
  36. ncbi Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis
    A Sabokbar
    Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford OX3 7LD, UK
    J Orthop Res 21:73-80. 2003
    ..We examined whether TNFalpha and IL-1alpha can directly induce osteoclast formation from human arthroplasty-derived (CD14(+)) macrophages by a mechanism independent of RANKL-induced osteoclastogenesis...
  37. ncbi A novel murine model of orthopaedic wear-debris associated osteolysis
    W Ren
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Scand J Rheumatol 33:349-57. 2004
    To develop a mouse model of bone resorption to quantitatively evaluate wear-debris induced osteolysis.
  38. pmc Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity
    Dan Li
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:96-105. 2008
    ..in vivo model that can quantify the bacterial load, metabolic activity of the bacteria over time, immunity, and osteolysis. To overcome these obstacles, we developed a murine model of implant-associated OM in which a stainless steel ..
  39. ncbi Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone
    Z G Li
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    Oncogene 27:596-603. 2008
    ..We conclude that MDA PCa 2b induces new bone formation through Wnt canonical signaling, that LRP5 mediates this effect, and that DKK1 is involved in the balance between bone formation and resorption that determines lesion phenotype...
  40. ncbi RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes
    Allison P Armstrong
    Department of Hematology, Amgen Inc, Seattle, Washington 98119, USA
    Prostate 68:92-104. 2008
    ..RANK expression has also been observed in some tumor cell types such as breast and colon, suggesting that RANKL may play a direct role on tumor cells...
  41. pmc Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation
    Michael Darowish
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Bone 45:661-8. 2009
    ..Thus, the absence of IL-6 results in increased inflammatory bone loss...
  42. pmc IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis
    Jesse E Otero
    Department of Orthopedics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 25:1282-94. 2010
    ..More important, adenoviral gene transfer of IKKbeta(SSEE) induced osteoclasts and osteolysis in calvariae and knees of mice...
  43. doi Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli
    Andrew Gordon
    Academic Unit of Bone Metabolism, Sorby Wing, Department of Human Metabolism, Northern General Hospital, University of Sheffield, Herries Road, Sheffield S5 7AU, United Kingdom
    J Orthop Res 28:1127-35. 2010
    Susceptibility to osteolysis after total hip arthroplasty (THA) varies between individuals...
  44. pmc Advances in the understanding of myeloma bone disease and tumour growth
    Shmuel Yaccoby
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 149:311-21. 2010
    ..Unravelling mechanisms of myeloma bone disease expands horizons for developing novel interventions and also facilitates better understanding of the association between induction of osteolysis and disease progression.
  45. pmc Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles
    Christine A St Pierre
    Department of Medicine, University of Massachusetts Medical School, Lazare Research Building, Room 228, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    J Orthop Res 28:1418-24. 2010
    b>Osteolysis of bone following total hip replacement is a major clinical problem. Examination of the areas surrounding failed implants has indicated an increase in the bone-resorption-inducing cytokine, interleukin 1β (IL-1β)...
  46. pmc Vitamin E diffused, highly crosslinked UHMWPE: a review
    Ebru Oral
    Harris Orthopaedic Laboratory, Massachusetts General Hospital, 55 Fruit St GRJ 1206, Boston, MA 02114, USA
    Int Orthop 35:215-23. 2011
    ..1990s, show significant improvements compared to gamma sterilised, conventional UHMWPE in decreasing wear and osteolysis. These crosslinked UHMWPEs were thermally treated (annealed or melted) after irradiation to improve their ..
  47. pmc Thirty years of experience with alumina-on-alumina bearings in total hip arthroplasty
    Didier Hannouche
    Department of Orthopaedic Surgery and Traumatology, AP HP, Hôpital Lariboisière University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
    Int Orthop 35:207-13. 2011
    ..4% at ten years. However, concern remains over ceramic liner fracture and squeaking, which has been noted recently with increasing prevalence. This review will discuss the current knowledge on the use of alumina-on-alumina bearings...
  48. pmc Less wear with aluminium-oxide heads than cobalt-chrome heads with ultra high molecular weight cemented polyethylene cups: a ten-year follow-up with radiostereometry
    Jon Dahl
    Orthopaedic Department, Oslo University Hospital, N 0407, Oslo, Norway
    Int Orthop 36:485-90. 2012
    Wear is a major contributor to osteolysis and aseptic loosening of total hip replacements (THR). Both alumina (Al(2)O(3)) and cobalt-chrome (CoCr) femoral heads are commonly used...
  49. doi The aqueous extract of Angelica sinensis, a popular Chinese herb, inhibits wear debris-induced inflammatory osteolysis in mice
    Chongfei Yang
    Institute of Orthopedic Surgery, Xijing Hostpital, The Fourth Military Medical University, Xi an, China
    J Surg Res 176:476-83. 2012
    ..We investigated effects of aqueous extract of AS on inflammatory cytokines release and wear debris particles-induced osteolysis.
  50. pmc CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
    Daniel J Dairaghi
    ChemoCentryx Inc, 850 Maude Ave, Mountain View, CA 94043, USA
    Blood 120:1449-57. 2012
    ..These results provide a strong rationale for further development of CCR1 antagonists for the treatment of MM and associated osteolytic bone disease...
  51. ncbi A report of three patients with MMP2 associated hereditary osteolysis
    S A Temtamy
    Department of Clinical Genetics, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt
    Genet Couns 23:175-84. 2012
    b>Osteolysis syndromes are rare hereditary disorders characterized by destruction and resorption of affected bones...
  52. pmc Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome
    Brad R Evans
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Am J Hum Genet 91:572-6. 2012
    The "vanishing bone" syndromes represent a group of rare skeletal disorders characterized by osteolysis and joint destruction, which can mimic severe rheumatoid arthritis...
  53. doi Skeletal-related events and clinical outcomes in patients with bone metastases and normal levels of osteolysis: exploratory analyses
    A Lipton
    Penn State Cancer Center, Milton S Hershey Medical Center, Pennsylvania State University, Division of Hematology Oncology, Hershey, PA 17033, USA
    Clin Oncol (R Coll Radiol) 25:217-26. 2013
    ..However, the disease course has not been well characterised in patients with bone metastases but normal NTX levels. Therefore, the aim of this study was to evaluate the patterns of skeletal morbidity in patients with normal NTX levels...
  54. pmc Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21
    Elizabeth A Blaber
    Space Biosciences Division, NASA Ames Research Center, Moffett Field, California, USA
    PLoS ONE 8:e61372. 2013
    ..and unloading are known to cause osteoclast-mediated bone resorption; however, we hypothesize that osteocytic osteolysis, and cell cycle arrest during osteogenesis may also contribute to bone loss in space...
  55. ncbi The decrease of particle-induced osteolysis after a single dose of bisphosphonate
    Marius von Knoch
    Department of Orthopaedics, University of Duisburg Essen, Pattbergstrasse 1 3, 45239 Essen, Germany
    Biomaterials 26:1803-8. 2005
    The most common cause of implant failure in joint replacement is aseptic loosening due to particle-induced osteolysis. Bisphosphonates have been shown to be effective against particle-induced osteolysis when administered daily...
  56. ncbi The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bone
    Peter G Whang
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    J Orthop Res 23:1475-83. 2005
    ..These results indicate that in vivo RANK blockade may not be effective for the prevention of osteoblastic metastasis but may potentially represent a novel therapy that limits the growth of established metastatic CaP lesions in bone...
  57. pmc Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear
    R John Looney
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res 4:59-63. 2002
    b>Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area...
  58. ncbi Immunocytochemistry reveals RANKL expression of myeloma cells
    Orhan Sezer
    Blood 99:4646-7; author reply 4647. 2002
  59. ncbi Regulation of osteoclast activity in peri-implant tissues
    D R Haynes
    Department of Pathology, University of Adelaide, Adelaide, 5005 South Australia, Australia
    Biomaterials 25:4877-85. 2004
    ..in a number of bone loss pathologies in humans and have the potential for successful treatment of peri-implant osteolysis. In addition, understanding how different biomaterials influence the expression of key osteoclastogenic factors ..
  60. ncbi A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice
    Shinsaku Otsuka
    Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Gradate School, Tokushima, 770 8503, Japan
    Oncol Res 17:581-91. 2009
    ....
  61. pmc Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis
    Shamik Das
    Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604, USA
    J Biol Chem 286:9612-22. 2011
    ..Our studies suggest that inhibiting Hh signaling interferes with the ability of pre-osteoclasts to respond to the stimulatory effects of the breast cancer cells, indicating that Hh signaling is vital to osteoclast activity...
  62. ncbi Magnetic resonance imaging in the evaluation of periprosthetic acetabular osteolysis: a cadaveric study
    Daniel E Weiland
    Hospital for Special Surgery, New York, NY 10021, USA
    J Orthop Res 23:713-9. 2005
    Periprosthetic osteolysis is a well recognized complication of total hip arthroplasty that leads to implant failure...
  63. ncbi Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis
    J Gallo
    Department of Orthopaedics, I P Pavlova 6, Olomouc, Czech Republic
    Physiol Res 57:339-49. 2008
    ..particle disease, and this may lead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have been reported in the past, including RANKL/RANK/OPG/TRAF6, TNF-..
  64. pmc Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis
    Radhashree Maitra
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Immunol 47:175-84. 2009
    ..These two processes synergistically results in the initiation of a strong inflammatory response with consequent cellular necrosis and extracellular matrix degradation...
  65. pmc History and systematic review of wear and osteolysis outcomes for first-generation highly crosslinked polyethylene
    Steven M Kurtz
    Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 469:2262-77. 2011
    Highly crosslinked polyethylene (HXLPE) was introduced to reduce wear and osteolysis in total joint arthroplasty...
  66. ncbi The rates of osteolysis and loosening associated with a modular posterior stabilized knee replacement. Results at five to fourteen years
    Paul F Lachiewicz
    Department of Orthopaedics, University of North Carolina, Chapel Hill, 242 Burnett Womack Building, CB 7055, Chapel Hill, NC 27599, USA
    J Bone Joint Surg Am 86:525-30. 2004
    b>Osteolysis and increased polyethylene wear have been reported in association with several designs of modular total knee prostheses...
  67. ncbi Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity
    Kirk Ho Man Yip
    Molecular Orthopaedic Laboratory, School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia
    J Bone Miner Res 19:1905-16. 2004
    ..In this study, we showed that PAR, an NF-kappaB inhibitor found in medicinal herbs, can block LPS-induced osteolysis. PAR does this by inhibiting osteoclastogenesis and bone resorption and promoting apoptosis of osteoclasts ..
  68. ncbi Acetabular revision using a trabecular metal acetabular component for severe acetabular bone loss associated with a pelvic discontinuity
    Scott M Sporer
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois Central Dupage Hospital, Winfield, Illinois, USA
    J Arthroplasty 21:87-90. 2006
    ..The treatment of pelvic discontinuity during acetabular revision using a trabecular metal acetabular component with or that without an associated trabecular metal augment appears to provide reliable and reproducible short-term results...
  69. pmc Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface
    Kalyan C Nannuru
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5900, USA
    Cancer Res 70:3494-504. 2010
    ..To determine the functional role of MMP13 in tumor-induced osteolysis, mice with Cl66 mammary tumors were treated with MMP13 antisense oligonucleotides (MMP13-ASO) or control ..
  70. doi Vertebral osteolysis originating from subchondral cyst end plate defects in transforaminal lumbar interbody fusion using rhBMP-2. Report of two cases
    Sarah Balseiro
    Department of Biology, University of North Florida, Jacksonville, FL 32224, USA
    Spine J 10:e6-e10. 2010
    Vertebral osteolysis has been reported as a complication of off-label recombinant human bone morphogenetic protein-2 (rhBMP-2) use in transforaminal lumbar interbody fusion (TLIF)...
  71. pmc Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT
    Ryosuke Tsutsumi
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642 0001, USA
    J Orthop Res 26:1340-6. 2008
    ..we tested the hypothesis that osteoprotegerin (OPG) is more effective in preventing wear debris-induced osteolysis than zoledronic acid (ZA) or alendronate (Aln) in the murine calvaria model using in vivo micro-CT and ..
  72. ncbi Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions
    O Peyruchaud
    INSERM Research Unit 403, , Lyon, France
    J Bone Miner Res 16:2027-34. 2001
    ....
  73. ncbi Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
    Yoshihisa Mori
    Division of Endocrinology and Metabolism, Department of Medicine, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Blood 104:2149-54. 2004
    ..cells in preferential colonization of myeloma cells in bone marrow and development of associated osteoclastic osteolysis through cell-cell interactions have been indicated...
  74. ncbi The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells
    Julie A Sterling
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cancer Res 66:7548-53. 2006
    Parathyroid hormone-related peptide (PTHrP) is a major factor involved in tumor-induced osteolysis caused by breast cancers that have metastasized to bone...
  75. pmc Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
    Michael L Cher
    Department of Urology, Protease Program, and Integrated Biostatistics Unit, The Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 100:7847-52. 2003
    ..These studies showed that maspin expression decreased tumor growth, reduced osteolysis, and decreased angiogenesis...
  76. ncbi Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis
    Michael Ulrich-Vinther
    Department of Orthopedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Joint Surg Am 84:1405-12. 2002
    Aseptic loosening of orthopaedic implants secondary to wear debris-induced osteolysis is a serious problem. Osteoprotegerin (OPG) is a natural decoy protein that inhibits osteoclast activation and bone resorption...
  77. ncbi Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology MSC 7762, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Blood 102:311-9. 2003
    ..data have implicated macrophage inflammatory protein-1alpha (MIP-1alpha) in multiple myeloma (MM)-associated osteolysis. However, it is unclear whether the chemokine's effects are direct, to enhance osteolysis, or indirect and ..
  78. ncbi Role of osteopontin in adhesion, migration, cell survival and bone remodeling
    Therese Standal
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Exp Oncol 26:179-84. 2004
    ..In this review focus will be on OPN in bone and its role in adhesion, migration and cell survival. These aspects of OPN biology are important in tumorigenesis...
  79. ncbi Progression of acetabular periprosthetic osteolytic lesions measured with computed tomography
    Donald W Howie
    Department of Orthopaedics and Trauma, Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, Australia
    J Bone Joint Surg Am 89:1818-25. 2007
    ..A better understanding of the factors associated with the size and/or progression of osteolytic lesions has been hampered by a lack of sensitivity of radiographic measurement techniques...
  80. doi Acetabular revision using an anti-protrusion (ilio-ischial) cage and trabecular metal acetabular component for severe acetabular bone loss associated with pelvic discontinuity
    Y Kosashvili
    Division of Arthroplasty, Orthopaedic Department Mount Sinai Hospital, 600 University Avenue, University of Toronto, Ontario, Canada
    J Bone Joint Surg Br 91:870-6. 2009
    ..The complications included two dislocations, one infection and one partial palsy of the peroneal nerve. Our findings indicate that treatment of pelvic discontinuity using the component-cage construct is a reliable option...
  81. doi Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis
    Conor C Lynch
    Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, TN, 37232, USA
    Bone 48:44-53. 2011
    ..subvert this process to generate lesions that are comprised of extensive areas of pathological osteogenesis and osteolysis. The resultant increase in bone matrix remodeling enhances cytokine/growth factor bioavailability thus creating ..
  82. ncbi Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
    A Sasaki
    Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Japan
    Int J Cancer 77:279-85. 1998
    ..The primary cellular mechanism of osteolysis associated with metastatic cancer is osteoclast-mediated...
  83. pmc The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells
    Colm Morrissey
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Prostate 70:412-24. 2010
    ..Tumor cells replace bone marrow and can elicit an osteoblastic, osteolytic, or mixed bone response. Our objective was to elucidate the mechanisms and key factors involved in promoting osteoclastogenesis in PCa bone metastasis...
  84. ncbi The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria
    Joscelyn M Tatro
    Department of Orthopadics, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106 5000, USA
    J Orthop Res 25:361-9. 2007
    ..This balance may regulate the rate of osteolysis in the murine calvaria model as well as in patients with aseptic loosening.
  85. ncbi Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice
    S G Kaar
    Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106-5000, USA
    J Orthop Res 19:171-8. 2001
    Aseptic loosening is the most common cause of orthopaedic implant failure. This process is thought to be due to osteolysis induced by implant-derived wear particles...
  86. ncbi Effects of alendronate on particle-induced osteolysis in a rat model
    Peter J Millett
    The Hospital for Special Surgery, New York, NY 10021, USA
    J Bone Joint Surg Am 84:236-49. 2002
    Particle-induced osteolysis is currently a major problem affecting the long-term survivorship of total joint replacements. Alendronate is a third-generation bisphosphonate that blocks osteoclastic bone resorption...
  87. pmc Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption
    An Qin
    Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People s Republic of China
    PLoS ONE 7:e34132. 2012
    ..It is well established that extensive bone destruction (osteolysis) by osteoclasts is responsible for wear particle-induced peri-implant loosening...
  88. ncbi Treatment strategies for bone disease
    G D Roodman
    Department of Medicine Hematology Oncology, VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Bone Marrow Transplant 40:1139-46. 2007
    ..New therapies that can target both the tumor as well as the severe bone disease should be on the horizon to treat this devastating complication of myeloma...
  89. doi Osteolysis after unidirectional and multidirectional mobile-bearing total knee arthroplasty in young patients
    Young Hoo Kim
    Joint Replacement Center of Korea, Ewha Womans University School of Medicine, Seoul, South Korea
    J Arthroplasty 24:586-93. 2009
    ..knee arthroplasties in terms of clinical results and the prevalence of polyethylene wear and periprosthetic osteolysis. We studied 62 patients who underwent simultaneous bilateral total knee arthroplasties, with a unidirectional ..
  90. doi Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand
    Thomas J Wilson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5845, USA
    Cancer Res 68:5803-11. 2008
    ..of cathepsin G in a coculture model and that in vivo inhibition of cathepsin G reduces mammary tumor-induced osteolysis. Together, our data indicate that cathepsin G activity at the tumor-bone interface plays an important role in ..
  91. ncbi Genetic linkage of familial expansile osteolysis to chromosome 18q
    A E Hughes
    Department of Medical Genetics, Queen s University of Belfast, UK
    Hum Mol Genet 3:359-61. 1994
    Familial expansile osteolysis is a rare bone dysplasia which is transmitted as an autosomal dominant trait in a large kindred in Northern Ireland...
  92. ncbi Cytokines and osteolysis around total hip prostheses
    S Stea
    Putti Department, Istituti Ortopedici Rizzoli, Bologna, Italy
    Cytokine 12:1575-9. 2000
    The aim of this work is to assess the correlation between the osteolysis around the prosthesis and the presence of cytokines favouring inflammation in the tissues at the interface between loosened prosthesis and bone...
  93. pmc Keratin particle-induced osteolysis: a mouse model of inflammatory bone remodeling related to cholesteatoma
    R A Chole
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Assoc Res Otolaryngol 2:65-71. 2001
    ..While not useful for the study of the root cause of cholesteatoma, this model will allow the study ofpathologic bone remodeling related to cholesteatoma in a genetically defined animal...
  94. ncbi Effect of acetabular modularity on polyethylene wear and osteolysis in total hip arthroplasty
    Anthony M Young
    Anderson Orthopaedic Research Institute, Alexandria, VA 22307, USA
    J Bone Joint Surg Am 84:58-63. 2002
    Debris from polyethylene wear causes osteolysis. In this study, we examined the effect of acetabular liner modularity on polyethylene wear and osteolysis.
  95. ncbi Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis
    J Jeffrey Goater
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 20:169-73. 2002
    ..Central to the etiology of aseptic loosening is periprosthetic osteolysis at the bone-implant interface, which is caused by wear debris-induced inflammation...
  96. ncbi Does pelvic osteolysis occur with a nonmodular uncemented acetabular component?
    Geoffrey Horne
    Department of Orthopaedic Surgery, Wellington School of Medicine, Wellington South, New Zealand
    J Arthroplasty 21:185-90. 2006
    ..No cup has been revised for aseptic loosening. There was no radiographic evidence of periacetabular osteolysis or loosening of any of the cups, even in a subgroup of 31 patients who were 60 years or younger at the time of ..
  97. ncbi Cross-linked N-telopeptide of type I collagen (NTx) in urine as a predictor of periprosthetic osteolysis
    Thord von Schewelov
    Department of Orthopedics, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Orthop Res 24:1342-8. 2006
    Periprosthetic osteolysis is often nonsymptomatic and hard to visualize by conventional radiography...
  98. ncbi Serum levels of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand as markers of periprosthetic osteolysis
    Donatella Granchi
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Am 88:1501-9. 2006
    ..The aim of this study was to evaluate whether the circulating levels of OPG and RANKL, as well as their ratio, could be different in patients with aseptic loosening compared with patients with stable implants...
  99. ncbi Blockade of vascular endothelial growth factor activity suppresses wear debris-induced inflammatory osteolysis
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Rheumatol 34:27-35. 2007
    ..Our study examined the hypothesis that wear debris may influence vascular endothelial grow factor (VEGF) expression, and that blocking VEGF bioactivity might improve wear debris-induced inflammatory osteolysis in a mouse model.
  100. ncbi CT and MRI of hip arthroplasty
    J G Cahir
    Department of Radiology, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
    Clin Radiol 62:1163-71; discussion 1172-3. 2007
    ..CT and MRI have now become useful imaging techniques in the assessment of hip arthroplasty...
  101. doi Influence of mouse genetic background on wear particle-induced in vivo inflammatory osteolysis
    C Zhang
    Department of Orthopaedics, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People s Republic of China
    Inflamm Res 57:211-5. 2008
    Genetics may influence wear particle-induced inflammatory osteolysis after joint replacement. In the present work, mice with three different genetic backgrounds were used to test this hypothesis.

Research Grants66

  1. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..central to many bone-related conditions such as osteoporosis, osteonecrosis of the jaw, stress fractures and osteolysis. Understanding the response of bone at the cellular level to mechanical loading is critical to eradicating these ..
  2. Francis Young In Lee; Fiscal Year: 2016
    ..overlooked target for inhibiting osteoclastogenesis, IL-1b, an inflammatory cytokine implicated in pathologic osteolysis. An IL-1b Converting Enzyme (ICE, or Caspase-1) inhibitor showed dramatic inhibition of osteoclastogenesis...
  3. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
    ..in the plasma membrane of macrophages, to direct the elaboration of inflammatory cytokines responsible for osteolysis (e.g. RANKL)...
  4. Anti-Autolysin Passive Immunity for MRSA Osteomyelitis
    JOHN LINFORTH DAISS; Fiscal Year: 2010
    ..This leads to a highly reproducible infection with osteolysis by day 9, fractures within three weeks, and closely resembles clinical OM around an external fixation pin...
  5. Yousef Abu-Amer; Fiscal Year: 2016
    ..However, implant-derived wear debris occurs with time causing inflammatory responses culminating with osteolysis and failure of implants...
  6. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
    ..via inhibition of iNOS in osteoclasts and that tumor-derived TSP1 contributes to increased tumor-associated osteolysis in bone metastasis...
  7. Urszula T Iwaniec; Fiscal Year: 2015
    ..bone loss induced by polyethylene particles (placed onto calvarium to model arthroplasty wear particle-induced osteolysis) strongly support this hypothesis. We propose to test our hypothesis by accomplishing two Aims...
  8. KATHERINE NELSON WEILBAECHER; Fiscal Year: 2014
    ..integrin stimulatory pathways in platelets and myeloid cells will disrupt tumor growth in bone and tumor-driven osteolysis. Thus, our Specific Aims are to: 1...
  9. Lionel B Ivashkiv; Fiscal Year: 2016
    ..We anticipate that our studies will provide insights that can be utilized to modulate the balance of activating and suppressive ITAM-mediated signaling therapeutically to suppress inflammatory osteolysis in RA.
  10. Nadim James Hallab; Fiscal Year: 2016
    ..this proposal is to determine both the utility of this approach an how best to mitigate implant debris induced osteolysis. Several key questions are: 1) what component(s) of the inflammasome pathway are best targeted to reduce debris-..
  11. Scott L Kominsky; Fiscal Year: 2016
    ..the molecular and cellular mechanisms that regulate the establishment of bone metastasis and tumor-induced osteolysis remain poorly understood...
  12. Stuart B Goodman; Fiscal Year: 2016
    ..Wear particles stimulate chronic inflammation that delays osseointegration, and leads to peri-prosthetic osteolysis and implant loosening...
  13. Francis Young In Lee; Fiscal Year: 2015
    ..significant progress in delineating molecular pathways such as NFATc1 and pERK1/2 in the context of inflammatory osteolysis. In order to translate our findings into a preclinical arena, we screened several drug candidates and identified ..
  14. Yousef Abu-Amer; Fiscal Year: 2016
    ..Conversely, abnormal activity of this transcription factor causes deleterious inflammatory osteolysis. In fact, we discovered recently that constitutive activation of IKK2 is sufficient to induce RANKL-independent ..
  15. Role of Beta 3 Integrin in Skeletal Metastasis
    Katherine Weilbaecher; Fiscal Year: 2009
    ..upstream activator of [unreadable]3 integrin, on platelets and osteoclasts during skeletal metastasis and tumor osteolysis. 3. Evaluate the role of integrin associated protein (CD47) during skeletal metastasis and tumor osteolysis...
  16. INTEGRIN SIGNALING PATHWAYS IN PROSTATE CANCER
    LUCIA LANGUINO; Fiscal Year: 2009
    ..In a parallel series of experiments, we have also found that [unreadable]v[unreadable]6 promotes tumor-mediated osteolysis, a crucial step in prostate cancer metastasis ("late phases")...
  17. Arnold I Caplan; Fiscal Year: 2016
    ..cells, their progression in time as metastatic tumors and the anatomical/functional correlation of resulting osteolysis (analyzed by ?CT imaging), which will be also assessed by histology, histomorphometry and serum markers...
  18. Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-J
    Baohong Zhao; Fiscal Year: 2013
    ..leading to musculoskeletal tissue damage and accelerating pathogenesis of diseases characterized by inflammatory osteolysis, including rheumatoid arthritis (RA), psoriatic arthritis, periodontitis an peri-prosthetic loosening...
  19. A Role of Novel Serpin Maspinin Prostate Tumor/Bone Interaction
    Shijie Sheng; Fiscal Year: 2012
    ..In particular, we have shown that maspin inhibits PC bone tumor growth, PC-induced osteolysis, and PC bone tumor angiogenesis...
  20. Deborah V Novack; Fiscal Year: 2015
    ..factors that increase the number and activity of OCs, creating a positive feedback loop for tumor-mediated osteolysis. Understanding the mechanisms of OC activation and how they change the microenvironment to one more favorable ..
  21. ROLAND E BARON; Fiscal Year: 2016
    ..hyper-parathyroidism for instance) or local (rheumatoid arthritis, periodontal disease, multiple myeloma, tumor osteolysis etc.). Despite the existence of several anti- resorptive drugs, evidence of unwanted effects is emerging...
  22. Nucleosides and TREM2 Mediate Inflammation-Induced Bone Loss
    George Pan; Fiscal Year: 2010
    Inflammation-induced osteolysis, such as occurs in rheumatoid and psoriatic arthritis, is one of the most common skeletal diseases...
  23. MARKUS ANTON WIMMER; Fiscal Year: 2014
    ..The frontside medial and lateral bearing surfaces of TKRs are not the only surfaces which contribute to wear and osteolysis. Micromotion between the back of the polyethylene liner and the metallic base plate/tray leads to "backside wear"..
  24. KARL LEONARD INSOGNA; Fiscal Year: 2015
    ..In order to examine the role of the TSP1/CD47 interaction in myeloma-induced osteolysis we will pursue three specific aims...
  25. Biotribological Layers in Metal-on-Metal Hip Replacement
    Joshua J Jacobs; Fiscal Year: 2010
    ..These adverse responses, which include periprosthetic bone loss (osteolysis), delayed-type hypersensitivity and soft tissue masses (so-called pseudotumors) are governed by the local ..
  26. NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone Metastasis
    Cun Yu Wang; Fiscal Year: 2013
    ..contrast to prostate cancer which forms osteoblastic lesion, bone metastasis of breast cancer typically leads to osteolysis which is often accompanied with severe pain, pathological fracture, and hypercalcaemia...
  27. Roberto Civitelli; Fiscal Year: 2016
    ..biomechanics, ectopic calcification, as well as mouse and human genetics, bone metastasis and inflammatory osteolysis. The training will consist of 4 components: 1) mentored research training;2) core curriculum coursework;3) ..
  28. Lionel B Ivashkiv; Fiscal Year: 2016
    ..Thus, inflammation induces local bone erosion/osteolysis at inflammatory sites in diseases such as rheumatoid arthritis, periodontitis, infections, and orthopedic ..
  29. Xu Feng; Fiscal Year: 2016
    ..various bone diseases such as postmenopausal osteoporosis, bone loss in rheumatoid arthritis, and tumor-induced osteolysis, a full elucidation of RANK signaling may guide the development of new therapeutic targets for these bone ..
  30. KATHERINE NELSON WEILBAECHER; Fiscal Year: 2015
    ..and RANK ligand (RANKL) pathway plays a central role in bone destruction through osteoclast differentiation and osteolysis due to bone metastasis, which occurs in 70% of women with breast cancer...
  31. Stuart B Goodman; Fiscal Year: 2016
    ..to the protein eluting titanium implant, thereby improving bone apposition and decreasing peri- implant osteolysis, using the murine continuous polyethylene particle infusion model...
  32. Ralph D Sanderson; Fiscal Year: 2016
    ..have shown that the heparan sulfate degrading enzyme heparanase is a key driver of myeloma growth, angiogenesis, osteolysis and metastasis...
  33. Bioengineering Research Partnership in Total Joint Replacements
    Yogesh K Vohra; Fiscal Year: 2012
    ..Complications arising from wear include component loosening, deleterious biological responses, osteolysis, mechanical instability, decreased joint mobility, increased pain, and ultimately implant failure...
  34. REGULATION OF RUNX-2 TRANSCRIPTIONAL ACTIVITY
    Jennifer J Westendorf; Fiscal Year: 2010
    ..It also contributes to T cell lymphomogenesis and breast cancer-associated osteolysis and skeletal disease. Runx2 is both an activator and represser of gene expression...
  35. Lucia R Languino; Fiscal Year: 2014
    ..Expression of av[unreadable]6 also causes tumor-mediated osteolysis, a crucial step in prostate cancer metastasis...
  36. Mehran Armand; Fiscal Year: 2016
    ..that, on average, less than 50% of the lesion is actually grafted due to difficulty in accessing the areas of osteolysis behind the acetabular component...
  37. Yang Yang; Fiscal Year: 2015
    ..cells is a major determinant of the osteolytic phenotype where it potently promotes both local and systemic osteolysis. The goal of this project is to determine how heparanase promotes myeloma-induced bone disease and to determine ..
  38. Janet L Stein; Fiscal Year: 2015
    ..in leukemia and breast cancer;and 5) contributions of regulatory protein subnuclear targeting for control of osteolysis by metastatic breast tumors...
  39. Claudia Fischbach; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Breast cancer frequently metastasizes to bone where it leads to osteolysis and poor clinical prognosis;however, the underlying roles of hydroxyapatite (HA) - a key component of breast ..
  40. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven L Teitelbaum; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Inflammatory osteolysis, as occurs in rheumatoid arthritis and orthopedic implant loosening, reflects accelerated osteoclast (OC) recruitment and activation...
  41. Florent Elefteriou; Fiscal Year: 2016
    ..the bone microenvironment in response to SNS activation, in addition to their effect on osteoclastogenesis and osteolysis. We propose in this application to characterize the cellular and molecular mechanisms underlying these SNS ..
  42. Steven L Teitelbaum; Fiscal Year: 2016
    ..integrin is a current therapeutic anti-resorptive target for diseases such as osteoporosis and inflammatory osteolysis. The purpose of this grant, from its inception, has been to expand the potential of therapeutically targeting ..
  43. Ralph D Sanderson; Fiscal Year: 2014
    ..Using in vivo models, we have also shown that heparanase is a key driver of myeloma growth, osteolysis and metastasis...
  44. C CASEY CHEN; Fiscal Year: 2016
    ..the virulence of Aa in periodontitis via Th17 and regulatory T cell immune responses;the former leads to osteolysis and tissue destruction, while the latter dampens the inflammatory response...
  45. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    ..cell tumor of bone, Paget's disease, metastatic breast cancer, multiple myeloma, and familial expansile osteolysis. Osteoprotegerin (OPG, also known as OCIF/TR1) is a soluble, decoy receptor that inhibits RANKL from binding to ..
  46. Heparanase regulation of tumor host interactions in myeloma and breast cancer
    Ralph D Sanderson; Fiscal Year: 2012
    ..effects that dramatically alter the tumor microenvironment to stimulate growth, angiogenesis, metastasis and osteolysis of bone-homing tumors...
  47. GENETIC BASES FOR DISEASES OF THE RANK SIGNALING PATHWAY
    STEVEN R MUMM; Fiscal Year: 2013
    ..activator of nuclear factor ?-B) gene was determined to be the cause of a related disorder, familial expansile osteolysis (FEO)...
  48. Effect of Tumors on the Skeleton
    Florent Elefteriou; Fiscal Year: 2010
    ..including mechanisms responsible for the stimulatory effect of TGF/8 on PTH-rP expression and subsequent osteolysis, regulation of expression of the bone resorbing peptide PTH-rP by breast cancer cells, molecular interactions ..
  49. Dong Wang; Fiscal Year: 2016
    ..theranostic tool for early diagnosis and effective treatment of peri-implant orthopedic wear particle-induced osteolysis. Orthopedic wear particle-induced inflammation is considered to be the major cause of aseptic implant loosening ..
  50. Hollis G Potter; Fiscal Year: 2016
    ..Alternative bearing surfaces, such as ceramics and metals, were developed as an alternative to MOP to reduce osteolysis due to polyethylene wear...
  51. Understanding phosphate metabolism in cancer and metastasis
    Dorothea Fiedler; Fiscal Year: 2013
    ..We are developing small-molecule fluorescent phosphate sensors to measure phosphate release during osteolysis and phosphate uptake in adjacent metastatic breast cancer cells...
  52. Novel GPCR Kinase Interactions in Macrophages and Role in Arthritis
    Narayanan Parameswaran; Fiscal Year: 2009
    ..In Inflammatory osteolysis (resorption or dissolution of bone due to inflammation) observed in disorders such as rheumatoid arthritis, ..
  53. POSITIONAL CLONING OF PYCNODYSOSTOSIS
    Bruce Gelb; Fiscal Year: 2000
    ..Pycno, a rare, autosomal recessive skeletal dysplasia, is characterized by short stature, osteosclerosis, acro-osteolysis, bone fragility, clavicular dysplasia and skull deformities...
  54. TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT
    Jorge Galante; Fiscal Year: 2000
    ..The central hypothesis is that (in the absence of osteolysis related to degradation of the implant) stress-shielding represents the most important independent variable or "..
  55. Quantitative periprosthetic PET/CT
    Thomas Lang; Fiscal Year: 2009
    ..One of the most challenging diagnostic aspects of the painful implant is the differentiation between aseptic osteolysis, an inflammatory response to infiltration of wear debris, and infection of the tissue surrounding the joint...
  56. BONE MATRIX BOUND GROWTH FACTORS AND BREAST CANCER
    SARAH DALLAS; Fiscal Year: 2003
    ..the release of bone matrix-bound TGFb by breast cancer cells may potentially be developed as a new treatment strategy to reduce cancer-associated osteolysis and alleviate the suffering of patients with bone metastatic breast cancer.
  57. WEAR DEBRIS OSTEOLYSIS--NEW STRATEGIES FOR PREVENTION
    REGIS O KEEFE; Fiscal Year: 2001
    DESCRIPTION (Adapted from the investigator's Abstract): Periprosthetic osteolysis surrounding joint arthroplasties leads to prosthetic loosening and failure and is one of the major issues facing our aging population...
  58. CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMA
    Marc Hansen; Fiscal Year: 2001
    ..This subregion has also been identified as the location for the locus for Familial Expansile Osteolysis (FEO), a hereditary disease similar to Paget's disease...
  59. Smart Substrates for a New Generation of Implants
    Irving Shapiro; Fiscal Year: 2009
    ..Effective countermeasures to prevent osteolysis and infection include the use of body exhaust systems, laminar airflow and prophylactic antibiotics...
  60. AL/ZIRCONIA COMPOSITE FILM FOR ORTHOPEDIC PROSTHESES
    Stephen Bunker; Fiscal Year: 1999
    ..Polyethylene wear debris is known to cause osteolysis which is a key factor in loosening of the prosthesis, leading to the need for a revision procedure...
  61. Gli Control of PTH-rP and Osteolysis in Breast Cancer
    Gregory Mundy; Fiscal Year: 2009
    ..PTH-rP) is the causative factor not only in humoral hypercalcemia of malignancy (HHM), but also in the local osteolysis associated with metastatic breast cancer...
  62. CERAMIC TIBIA FOR MOBILE BEARING KNEE
    Ashok Khandkar; Fiscal Year: 1999
    ..This has a great potential for implant applications in virtually eliminating wear particle mediated osteolysis and consequent implant failures...
  63. INVESTIGATE THE REGULATION OF BONE RESORPTION
    Timothy Chambers; Fiscal Year: 1991
    ..precursors of osteoclasts in normal individuals and in patients and laboratory animals with increased levels of osteolysis by immunocytochemistry and the ability to excavate bone slices...
  64. CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSIS
    Edward M Brown; Fiscal Year: 2004
    ..importantly to the pathophysiology of PTHrP-mediated, humoral hypercalcemia of malignancy as well as to the osteolysis that can be caused by bony metastases of common epithelial cancers (e.g., breast and prostate cancers)...
  65. MALIGNANCY-ASSOCIATED HYPERCALCEMIA
    Gordon Strewler; Fiscal Year: 1993
    ..PLP may also have a second role in the pathogenesis of hypercalcemia, inducing local osteolysis when secreted at low levels by betastatic tumors in bone...