thrombocytopenic purpura

Summary

Summary: Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.

Top Publications

  1. ncbi Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion
    Elizabeth M Cosmai
    Division of Hematology Oncology, University of Miami and Veterans Affairs Medical Center, Florida, USA
    Eur J Haematol 68:239-42. 2002
  2. ncbi Absence of cytokine modulation following therapeutic infusion of intravenous immunoglobulin or anti-red blood cell antibodies in a mouse model of immune thrombocytopenic purpura
    Eric Aubin
    Department of Research and Development, HEMA QUEBEC, QC, Canada
    Br J Haematol 136:837-43. 2007
  3. doi A possible role for low-dose cyclosporine in refractory immune thrombocytopenic purpura
    Giovanni Emilia
    Haematologica 93:1113-5. 2008
  4. ncbi Low platelet counts alone do not cause bleeding in an experimental immune thrombocytopenic purpura in mice
    Victoria Dominguez
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico
    Haematologica 88:679-87. 2003
  5. ncbi Severe thrombocytopenic purpura due to rubella infection in a patient with systemic lupus erythematosus
    F Boehlen
    Haemostasis Unit, Division of Angiology and Haemostasis, Department of Medicine, University Hospital, Geneva, Switzerland
    Lupus 12:144-6. 2003
  6. ncbi Thrombocytopenic purpura: an unusual complication of eradication therapy for Helicobacter pylori
    S Marchi
    Department of Internal Medicine, University of Pisa, Italy
    Dig Liver Dis 34:665-7. 2002
  7. ncbi Treatment of chronic immune thrombocytopenic purpura: the patients' perspective
    Axel Matzdorff
    Department of Haematology and Oncology, Caritasklinik St Theresia, Saarbruecken, Germany
    Eur J Haematol 78:381-8. 2007
  8. ncbi Immune thrombocytopenic purpura following influenza vaccination
    Moshe Tishler
    Department of Medicine B, Asaf Harofeh Medical Center, Zrifin, Israel
    Isr Med Assoc J 8:322-3. 2006
  9. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
  10. ncbi Antiphospholipid antibodies in immune thrombocytopenic purpura tend to emerge in exacerbation and decline in remission
    Carlos J Bidot
    Wallace H Coulter Platelet Laboratory, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
    Br J Haematol 128:366-72. 2005

Detail Information

Publications205 found, 100 shown here

  1. ncbi Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion
    Elizabeth M Cosmai
    Division of Hematology Oncology, University of Miami and Veterans Affairs Medical Center, Florida, USA
    Eur J Haematol 68:239-42. 2002
    Thrombocytopenia and hemolytic anemia have been seen with thrombotic thrombocytopenic purpura (TTP), HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), and hemolytic uremic syndrome (HUS)...
  2. ncbi Absence of cytokine modulation following therapeutic infusion of intravenous immunoglobulin or anti-red blood cell antibodies in a mouse model of immune thrombocytopenic purpura
    Eric Aubin
    Department of Research and Development, HEMA QUEBEC, QC, Canada
    Br J Haematol 136:837-43. 2007
    ..immunoglobulin (IVIg) and anti-D immunoglobulin preparations are used in the treatment of immune thrombocytopenic purpura (ITP)...
  3. doi A possible role for low-dose cyclosporine in refractory immune thrombocytopenic purpura
    Giovanni Emilia
    Haematologica 93:1113-5. 2008
  4. ncbi Low platelet counts alone do not cause bleeding in an experimental immune thrombocytopenic purpura in mice
    Victoria Dominguez
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico
    Haematologica 88:679-87. 2003
    The physiopathogenesis of hemorrhagic phenomena in patients with autoimmune thrombocytopenic purpura is associated with low platelet levels. In the present work the relation between thrombocytopenia and bleeding was examined...
  5. ncbi Severe thrombocytopenic purpura due to rubella infection in a patient with systemic lupus erythematosus
    F Boehlen
    Haemostasis Unit, Division of Angiology and Haemostasis, Department of Medicine, University Hospital, Geneva, Switzerland
    Lupus 12:144-6. 2003
    We report the case of a woman suffering from systemic lupus erythematosus who developed a severe thrombocytopenic purpura (platelet count < 1 x 10(9)/l) secondary to rubella infection...
  6. ncbi Thrombocytopenic purpura: an unusual complication of eradication therapy for Helicobacter pylori
    S Marchi
    Department of Internal Medicine, University of Pisa, Italy
    Dig Liver Dis 34:665-7. 2002
    A case of severe thrombocytopenic purpura is described in a 56-year-old female following Helicobacter pylori eradication therapy consisting of omeprazole, clarithromycin and amoxycillin...
  7. ncbi Treatment of chronic immune thrombocytopenic purpura: the patients' perspective
    Axel Matzdorff
    Department of Haematology and Oncology, Caritasklinik St Theresia, Saarbruecken, Germany
    Eur J Haematol 78:381-8. 2007
    The 1996 ASH guidelines recommend glucocorticoids and splenectomy as standard treatment of chronic immune thrombocytopenic purpura (ITP)...
  8. ncbi Immune thrombocytopenic purpura following influenza vaccination
    Moshe Tishler
    Department of Medicine B, Asaf Harofeh Medical Center, Zrifin, Israel
    Isr Med Assoc J 8:322-3. 2006
  9. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
    Immune thrombocytopenic purpura (ITP), a condition characterized by autoimmune-mediated platelet destruction and suboptimal platelet production, is associated with symptoms such as bruising, epistaxis, menorrhagia, mucosal bleeding from ..
  10. ncbi Antiphospholipid antibodies in immune thrombocytopenic purpura tend to emerge in exacerbation and decline in remission
    Carlos J Bidot
    Wallace H Coulter Platelet Laboratory, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
    Br J Haematol 128:366-72. 2005
    Although the presence of antiphospholipid antibodies (APLA) in immune thrombocytopenic purpura (ITP) has been reported, their clinical significance is not clear...
  11. ncbi Does treatment with intermittent infusions of intravenous anti-D allow a proportion of adults with recently diagnosed immune thrombocytopenic purpura to avoid splenectomy?
    Nichola Cooper
    Department of Pediatrics, Division of Hematology Oncology, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Blood 99:1922-7. 2002
    ..whether repeated infusions of intravenous anti-D could allow adults with recently diagnosed immune thrombocytopenic purpura (ITP) who had failed an initial steroid course to postpone and ultimately avoid splenectomy...
  12. ncbi Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients
    A R Gaines
    Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville Pike, Rockville, MD 20852, USA
    Blood 95:2523-9. 2000
    ..by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP)...
  13. pmc A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation
    Susan D Mathias
    Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA
    Health Qual Life Outcomes 5:11. 2007
    ..measures are available to assess health-related quality of life (HRQoL) in adult subjects with immune thrombocytopenic purpura (ITP)...
  14. ncbi Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura
    Ann Reed Gaines
    Division of Biostatistics and Epidemiology HFM 220, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    Blood 106:1532-7. 2005
    ..licensed Rh(o)(D) immune globulin intravenous (anti-D IGIV) on March 24, 1995, for treatment of immune thrombocytopenic purpura (ITP)...
  15. ncbi Schizocytosis in pernicious anemia mimicking thrombotic thrombocytopenic purpura
    Laurent Garderet
    Am J Med 114:423-5. 2003
  16. ncbi Persistent B-cell depletion after rituximab for thrombocytopenic purpura
    Gianni Bisogno
    Division of Hematology Oncology, Department of Pediatrics, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy
    Eur J Pediatr 166:85-6. 2007
  17. ncbi Laparoscopic splenectomy for idiopathic thrombocytopenic purpura (ITP)
    D E Pace
    The Centre for Minimally Invasive Surgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Surg Endosc 17:95-8. 2003
    ..We report our long-term follow-up data in patients who underwent LS for idiopathic thrombocytopenic purpura (ITP).
  18. ncbi Subconjunctival hemorrhage: the first presenting clinical feature of idiopathic thrombocytopenic purpura
    Punita Kumari Sodhi
    Department of Ophthalmology, Safdarjung Hospital, New Delhi, India
    Jpn J Ophthalmol 47:316-8. 2003
    Subconjunctival hemorrhage as the first presenting clinical feature of idiopathic thrombocytopenic purpura, to the best of our knowledge, has not been reported earlier.
  19. ncbi Phenotypic analysis of bone marrow lymphocytes from children with acute thrombocytopenic purpura
    Dalai E L Guiziry
    Department of Clinical Pathology, Alexandria University, Alexandria, Egypt
    Egypt J Immunol 12:9-14. 2005
    ..was to determine the incidence and clinical impact of bone marrow hematogones in cases of acute immune thrombocytopenic purpura (ITP) among children...
  20. ncbi Immune thrombocytopenic purpura: investigation of the role of cytomegalovirus infection
    Adam S Levy
    Br J Haematol 126:622-3. 2004
  21. ncbi Platelet-associated CD154 in immune thrombocytopenic purpura
    Anne Solanilla
    CNRS FRE 2617 and UMR 5540, Universite de Bordeaux 2, France
    Blood 105:215-8. 2005
    ..In this study, we show that platelet-associated CD154 is increased in immune thrombocytopenic purpura (ITP), a disease characterized by an autoimmune response against proteins of the platelet membrane...
  22. ncbi Health-related quality of life measured by the Short Form 36 in immune thrombocytopenic purpura: a cross-sectional survey in China
    Zeping Zhou
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China
    Eur J Haematol 78:518-23. 2007
    The aim of this study is to assess the quality of life (QoL) of Chinese adults with idiopathic thrombocytopenic purpura (ITP).
  23. ncbi The role of antiplatelet autoantibody assays in the diagnosis of immune thrombocytopenic purpura
    Robert McMillan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 215, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Hematol Rep 4:160-5. 2005
    Immune thrombocytopenic purpura (ITP) is a disorder almost always manifested by antibody-induced thrombocytopenia...
  24. ncbi Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura
    Z Tao
    Section of Thrombosis Research, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 4:1931-5. 2006
    Thrombotic thrombocytopenic purpura (TTP) is associated with congenital and acquired deficiency of ADAMTS-13, a metalloprotease that cleaves von Willebrand factor (VWF) and reduces its adhesive activity...
  25. ncbi Immune thrombocytopenic purpura
    V Gupta
    Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Indian J Pediatr 75:723-8. 2008
    Immune thrombocytopenic purpura (ITP) is the commonest cause of sudden onset thrombocytopenia in a healthy child. The condition is frequently preceded by a viral infection...
  26. ncbi Immune thrombocytopenic purpura - current management practices
    S Gerald Sandler
    Georgetown University Hospital, Department of Laboratory Medicine, 3800 Reservoir Road, NW, Washington, DC 20007, USA
    Expert Opin Pharmacother 5:2515-27. 2004
    The treatment of patients with immune thrombocytopenic purpura (ITP) is changing rapidly, as new agents demonstrate the capability of improving outcomes and decreasing toxicity...
  27. ncbi Thrombocytopenic purpura associated with brucellosis: report of 2 cases and literature review
    E J Young
    Medical Services, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Clin Infect Dis 31:904-9. 2000
    ..We describe 2 patients infected with Brucella melitensis who presented with thrombocytopenic purpura, and we review 41 additional cases from the literature...
  28. ncbi Comparison of platelet counts in first and second newborns of mothers with immune thrombocytopenic purpura
    G C Christiaens
    Department of Obstetrics and Gynaecology, Utrecht University Hospital, The Netherlands
    Obstet Gynecol 90:546-52. 1997
    This study was designed to estimate the predictive value of the first neonatal platelet count for the second neonate in women with immune thrombocytopenic purpura (ITP).
  29. ncbi Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients with essential thrombocythaemia and immune thrombocytopenic purpura
    Z C Han
    INSERM U 150, UA 334 CNRS, Institut des Vaisseaux et du Sang, Hopital Lariboisiere, Paris, France
    Br J Haematol 74:395-401. 1990
    ..colony formation in normal subjects as well as in essential thrombocythaemia (ET) and in immune thrombocytopenic purpura (ITP) was studied...
  30. ncbi The cost of treating immune thrombocytopenic purpura using intravenous Rh immune globulin versus intravenous immune globulin
    S G Sandler
    Department of Laboratory Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Hematol 63:156-8. 2000
    Multiple factors, including efficacy, toxicity and cost, may influence the decision to treat immune thrombocytopenic purpura (ITP) with intravenous immune globulin (IVIG) or intravenous Rho (D) immune globulin (IV RhIG)...
  31. ncbi Myocardial necrosis in patients with thrombotic thrombocytopenic purpura: pathophysiology and rationale for specific therapy
    David C Sane
    Section on Cardiology, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1082, USA
    Eur J Haematol 82:83-92. 2009
    Myocardial necrosis is now recognized as a common feature of thrombotic thrombocytopenic purpura (TTP), usually due to platelet plugging in the microvasculature...
  32. ncbi A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura
    G C Newman
    Divisions of Hematology/Oncology, New York Presbyterian Hospital-Weill Medical College of Cornell University, 525 E. 68th Street, New York, NY 10021, USA
    Br J Haematol 112:1076-8. 2001
    ..human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts < or = 30 x 109/l...
  33. ncbi Chronic immune thrombocytopenic purpura in children: assessment of rituximab treatment
    Julie Wang
    Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai Medical Center, New York, New York 10029, USA
    J Pediatr 146:217-21. 2005
    This study examined the efficacy and safety of rituximab in children with chronic immune thrombocytopenic purpura.
  34. ncbi Predictive factors for successful laparoscopic splenectomy in immune thrombocytopenic purpura: study of clinical and laboratory data
    C Balague
    Service of Surgery, Hospital de Sant Pau, C Padre Claret 167, 08025, Barcelona, Spain
    Surg Endosc 20:1208-13. 2006
    ..splenectomy (LS) offers better short-term results than open surgery for the treatment of immune thrombocytopenic purpura (ITP), but long-term follow-up is required to ensure its efficacy...
  35. ncbi Refractory immune thrombocytopenic purpura: current strategies for investigation and management
    Bethan Psaila
    Platelet Disorders Center, Division of Pediatric Hematology Oncology, Weill Cornell Medical College of Cornell University, New York, NY 10021, USA
    Br J Haematol 143:16-26. 2008
    There is currently no consensus on how best to manage refractory immune thrombocytopenic purpura (ITP)...
  36. ncbi Thrombocytopenic purpura associated with miliary tuberculosis
    Surat Tongyoo
    Intensive Care Unit, Division of Critical Care, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Med Assoc Thai 86:976-80. 2003
    ..Bone marrow examination is very helpful in this situation...
  37. ncbi Human granulocytic ehrlichiosis presenting with acute renal failure and mimicking thrombotic thrombocytopenic purpura. A case report and review
    K S Modi
    Division of Nephrology, Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Am J Nephrol 19:677-81. 1999
    ..and a small number of fragmented red cells on peripheral smear mimicking recurrent thrombotic thrombocytopenic purpura (TTP)...
  38. ncbi Chronic myelomonocytic leukemia developed 2 years after the onset of immune thrombocytopenic purpura like syndrome
    A U Ural
    Department of Hematology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    Haematologia (Budap) 30:221-4. 2000
    An 80-year old man was diagnosed as having immune thrombocytopenic purpura based on epistaxis, purpura and by the platelet count 8 x 10(9)/l...
  39. ncbi Laparoscopic splenectomy for hematologic disorders: experience with the first fifty patients
    Pradeep K Chowbey
    Department of Minimal Access Surgery, Sir Ganga Ram Hospital, New Delhi, India
    J Laparoendosc Adv Surg Tech A 15:28-32. 2005
    ..Splenectomy is increasingly being performed by various minimal access surgical modalities for select hematologic disorders...
  40. ncbi Spontaneous fatal intracranial hemorrhage in a child with Evans syndrome
    Antonio Ruggiero
    Division of Pediatric Oncology, Catholic University of Rome, Rome, Italy
    Pediatr Hematol Oncol 20:403-8. 2003
    ..Early recognition and aggressive management is required for an adequate management of this rare complication...
  41. ncbi Survey of the use and clinical effectiveness of HPA-1a/5b-negative platelet concentrates in proven or suspected platelet alloimmunization
    D L Allen
    National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
    Transfus Med 14:409-17. 2004
    ..Increased use and cost-effectiveness could be achieved by the delivery of an educational programme to neonatal unit clinical staff to increase the awareness and appropriate treatment of NAIT...
  42. ncbi Neonatal alloimmune thrombocytopenic purpura associated with HPA-5a
    Yukako Yoshikane
    Department of Pediatrics, Kyushu Kosei Nenkin Hospital, Fukuoka, Japan
    Pediatr Int 46:363-5. 2004
  43. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-2004. A newborn girl with a large cutaneous lesion, thrombocytopenia, and anemia
    John B Mulliken
    Division of Plastic Surgery, Craniofacial Center, and Vascular Anomalies Center, Children s Hospital, Boston, USA
    N Engl J Med 350:1764-75. 2004
  44. ncbi Serum IL-2 and platelet-associated immunoglobulins are good prognostic markers in immune thrombocytopenic purpura
    Lubna M Tag
    Department of Clinical Pathology, Assiut University, Assiut, Egypt
    Egypt J Immunol 11:121-32. 2004
    Immune thrombocytopenic purpura (ITP) is an acquired disease in which autoantibodies to platelets cause their sequestration and destruction by mononuclear macrophages, principally in the spleen...
  45. ncbi Clinical features and treatment outcomes of 79 infants with immune thrombocytopenic purpura
    Claudio Sandoval
    Department of Pediatrics and the Graduate School of Health Sciences, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Blood Cancer 42:109-12. 2004
    To determine the clinical features and treatment outcomes of infants with immune thrombocytopenic purpura (ITP).
  46. ncbi Use of intravenous anti-D in patients with refractory and relapsed immune thrombocytopenic purpura
    R Sajid
    Department of Pathology, The Aga Khan University, Karachi
    J Pak Med Assoc 53:537-9. 2003
    ..To determine the response to i.v. anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi...
  47. ncbi Initial management of children with newly diagnosed idiopathic thrombocytopenic purpura in the Nordic countries
    Iris Treutiger
    Paediatric Department of Sachs Children s Hospital, Stockholm, Sweden
    Acta Paediatr 95:726-31. 2006
    To describe the management practices of newly diagnosed childhood idiopathic thrombocytopenic purpura (ITP) in the Nordic countries.
  48. ncbi [Laparoscopic splenectomy in hematological diseases]
    Fernando Maluenda
    Departamento de Corugía, Hospital Clinico Universidad de Chile, Santiago
    Rev Med Chil 132:189-94. 2004
    Idiopathic thrombocytopenic purpura (ITP) is the most common indication for elective splenectomy. The laparoscopic approach has been used over the past ten years.
  49. ncbi Results of laparoscopic splenectomy for immune thrombocytopenic purpura
    Virachai Mahatharadol
    Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
    J Med Assoc Thai 89:821-5. 2006
    To study the safety and efficacy of Laparoscopic Splenectomy (LS) for Immune Thrombocytopenic Purpura (ITP).
  50. ncbi A single dose of anti-D immunoglobulin raises platelet count as efficiently as intravenous immunoglobulin in newly diagnosed immune thrombocytopenic purpura in Korean children
    Dong Woo Son
    Department of Pediatrics, Gil Medical Center, Gachon Medical School, Gachon University of Medicine and Science, Incheon, Korea
    J Pediatr Hematol Oncol 30:598-601. 2008
    The aim of this study is to compare the efficacy and safety of a single dose of anti-D immunoglobulin (anti-D) at 50 mug/kg to intravenous immunoglobulin (IVIG) in Korean children with acute immune thrombocytopenic purpura (ITP).
  51. ncbi Post-transfusion purpura (PTP) and disseminated intravascular coagulation (DIC)
    Karen Lise Welling
    Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Eur J Haematol 71:68-71. 2003
    ..The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values...
  52. doi Increasing the platelet count in chronic ITP
    Alan T Nurden
    Centre de Reference des Pathologies Plaquettaires, Hôpital Xavier Arnosan, 33600 Pessac, France
    Lancet 371:362-4. 2008
  53. ncbi Recombinant human interferon alpha-2a therapy in children with chronic immune thrombocytopenic purpura
    Hana Hrstkova
    Department of Pediatrics, Children s University Hospital Brno, Brno, Czech Republic
    J Pediatr Hematol Oncol 24:299-303. 2002
    In a prospective study, 11 children with chronic immune thrombocytopenic purpura between ages 3 and 18 years were treated with recombinant human interferon alpha 2a (rhIFN alpha-2a).
  54. ncbi Chronic ITP: analysis of various factors at presentation which predict failure to first line treatment and their response to second line therapy
    Naveen Naz Syed
    Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 57:126-9. 2007
    To observe the significance of various factors in chronic idiopathic thrombocytopenic purpura (ITP) which predict the response of first line (corticosteroids) and second line therapy (splenectomy) and to evaluate their response to second ..
  55. ncbi A second case of post-transfusion purpura caused by HPA-5a antibodies: successful treatment with intravenous immunoglobulin
    A Ziman
    Department of Transfusion Medicine, Cedars Sinai Medical Center, B700 Beverly Boulevard, Los Angeles, CA, USA
    Vox Sang 83:165-6. 2002
    ..She was successfully treated with intravenous immunoglobulin (IVIG), suggesting that this is a highly effective mode of treatment for PTP, regardless of the antibody implicated...
  56. ncbi [Pregnancy and delivery in women with thrombocytopenia]
    E Szkodny

    Ginekol Pol 72:1296-9. 2001
    ..Among all newborns only one had thrombocytopenia, platelet count 45,000 per cubic millimeter, without neonatal intracranial hemorrhage. 6 women had cesarean section and 2 patients delivered naturally...
  57. pmc Immune thrombocytopenic purpura during pregnancy: laparoscopic treatment
    B V Anglin
    Department of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas 75235-9092, USA
    JSLS 5:63-7. 2001
    ..CONCLUSION: Immune thrombocytopenia purpura can be an indication for splenectomy. As demonstrated in appendectomy, cholecystectomy, and our case presentation, laparoscopic splenectomy can be safely performed during pregnancy...
  58. ncbi Isolated splenic tuberculosis
    N Bheerappa
    Department of Surgical Gastroenterology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad-500 082, India
    Trop Gastroenterol 22:117-8. 2001
    ..One case presented as pyrexia of unknown origin (PUO) and another with idiopathic thrombocytopenic purpura (ITP). Both were found to have splenic tuberculosis after splenectomy...
  59. ncbi Immune thrombocytopenic purpura as a complication of Bartonella henselae infection
    Emilio Palumbo
    Dipartimento di Pediatria, Ospedale di Sondrio, Sondrio, Italy
    Infez Med 16:99-102. 2008
    Immune thrombocytopenic purpura is an infrequent yet well-recognized complication of viral infections, such as mumps, rubella, varicella, cytomegalovirus, parvovirus and infectious monunucleosis by Epstein-Barr virus...
  60. ncbi Evaluation of clinical characteristics, diagnosis and management in childhood immune thrombocytopenic purpura: a single center's experience
    Ulker Kocak
    Department of Pediatric Hematology, Gazi University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 49:250-5. 2007
    Diagnostic evaluation and management in childhood immune thrombocytopenic purpura (ITP) are controversial. We reviewed the files of 162 children with ITP to evaluate clinical characteristics, response to treatment and outcome...
  61. ncbi An unusual case of severe neonatal thrombocytopenia
    Cindy K Barney
    Neonatal Intensive Care Unit, McKay Dee Hospital, Intermountain Health Care, 4401 Harrison Boulevard, Ogden, UT 84403, USA
    Adv Neonatal Care 7:66-8. 2007
    ..The patient's platelet count remains normal at a 2-year follow-up. This case is reported as an instructive atypical case of NAIT, in which the relevant platelet antigen could not be identified...
  62. ncbi The natural history of maternal immunization against foetal platelet alloantigens
    H Ohto
    Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Transfus Med 14:399-408. 2004
    ..No cases of intracranial bleeding or death due to FMAIT were recorded. Generalized purpura due to FMAIT occurs in one in 9359 (95% CI: 1 in 77 519-1 in 2591) pregnancies solely because of HPA-4b incompatibility...
  63. ncbi Rapid and reliable genotyping of human platelet antigen (HPA)-1, -2, -3, -4, and -5 a/b and Gov a/b by melting curve analysis
    Ingrid Randen
    Departments of Immunology and Transfusion Medicine, Ulleval University Hospital, Kirkeveien 166, 0407 Oslo, Norway
    Transfusion 43:445-50. 2003
    The probability for occurrence of neonatal alloimmune thrombocytopenic purpura (NAITP) depends largely on the frequency of each individual phenotype in various populations...
  64. pmc Neonatal alloimmune thrombocytopenia, purpura, and anemia in 6 neonatal piglets
    Lorraine M Forster
    Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan
    Can Vet J 48:855-7. 2007
    ..Six piglets were affected and displayed signs of lethargy and depression with petechiation, ecchymosis, and severe bruising of the skin. All 6 piglets died or were euthanized by 3 days of age...
  65. ncbi Cardiobacterium hominis endocarditis associated with very severe thrombocytopenia and platelet autoantibodies
    Donald M Arnold
    Department of Hematology, McMaster University, Hamilton, Ontario, Canada
    Am J Hematol 76:373-7. 2004
    ..This report illustrates that the development of platelet autoantibodies can contribute to very severe thrombocytopenia in occasional patients with infective endocarditis...
  66. ncbi Severe HPA-15b related neonatal alloimmune thrombocytopenia
    P Moncharmont
    French Blood Establishment, Rhône Alpes Lyon Department, Lyon, France
    Acta Paediatr 96:1701-3. 2007
    ..The infant's PLT count was 267 x 10(9)/L on day 6. The maternal platelet group was HPA-15a/a and her infant was HPA-15a/b. Anti-HPA-15b antibodies was found in maternal serum...
  67. ncbi Defining the learning curve for laparoscopic splenectomy for immune thrombocytopenia purpura
    Michael B Peters
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, The Methodist Hospital, Michael E DeBakey VA Medical Center, 6550 Fannin, Suite 1661, Houston, TX 77030, USA
    Am J Surg 188:522-5. 2004
    The current study was undertaken to define the learning curve for laparoscopic splenectomy (LS) in patients with immune thrombocytopenic purpura (ITP).
  68. ncbi [The case of spleen's tumor and trombocytopenia in pregnant women]
    Katarzyna Leszczynska
    Klinika Połoinictwa Akademii Medycznej w Gdańisku
    Ginekol Pol 77:876-80. 2006
    ..Termination of the pregnancy by cesarean section was performed because of a big risk for the mother and child (tumor's crack, haemorrhage, infection). The same time the splenectomy was conducted. The results were successful...
  69. ncbi [Parvovirus B19 thrombocytopenic purpura complicated with a cerebral hemorrhage]
    P Tourneux
    Service de médecine néonatale et réanimation pédiatrique polyvalente, CHU d Amiens, Hopital Nord, 1, Place Victor Pauchet, 80054 Amiens Cedex 1, France
    Arch Pediatr 12:281-3. 2005
    Severe hemorrhage complications are rare in idiopathic thrombocytopenic purpura. This pathology is often considered as benign.
  70. ncbi 99mTc-sulphur-colloid and heat-denatured 99mTc-labelled red cell scans demonstrating a giant intrapelvic spleen in a girl after splenectomy
    P F Kao
    Department of Nuclear Medicine, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Tauyuan, Taiwan, Republic of China
    Pediatr Radiol 31:283-5. 2001
    ..The size and development of the giant intrapelvic spleen are unusual. The usefulness of functional images to diagnosis the nature of the intrapelvic mass is well demonstrated...
  71. ncbi Acute renal failure, translocational hyponatremia and hyperkalemia following intravenous immunoglobulin therapy
    Eugene Daphnis
    Department of Nephrology, University Hospital of Heraklion, Heraklion, Greece
    Nephron Clin Pract 106:c143-8. 2007
    ..Intravenous immunoglobulin (IVIG) therapy has been associated with renal adverse effects and electrolyte disturbances...
  72. ncbi Intravenous gamma globulin is effective as an urgent treatment in Brucella-induced severe thrombocytopenic purpura
    Fevzi Altuntas
    Department of Hematology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
    Am J Hematol 80:204-6. 2005
    ..We report a case of a patient infected with Brucella melitensis who was admitted with a severe case of thrombocytopenic purpura. The patient responded well to intravenous gamma globulin (IVIg) treatment with platelet recovery within ..
  73. ncbi Immune-mediated thrombocytopenic purpura associated with Toxoplasma gondii infection in an immunocompetent patient
    Melanie Deutsch
    Academic Department of Internal Medicine, Hippocration General Hospital, Athens, Greece
    Hematol J 5:538-9. 2004
    ..the case of a 16-year-old previous healthy adolescent who presented with bleeding due to immune-mediated thrombocytopenic purpura during an acute acquired T. gondii infection...
  74. ncbi Acute human parvovirus B-19 infection in hospitalized children: A serologic and molecular survey
    Dan Miron
    Department of Pediatrics A, Haemek Medical Center, Afula, Israel
    Pediatr Infect Dis J 25:898-901. 2006
    ..The extent and clinical manifestations of acute human parvovirus B19 (B19) infection were assessed in previously healthy hospitalized children admitted with clinical syndromes potentially associated the virus...
  75. ncbi Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children
    Eric K France
    Department of Preventive Medicine, Kaiser Pemanente Colorado, Denver, CO 80231, USA
    Pediatrics 121:e687-92. 2008
    ..The measles-mumps-rubella vaccine has been associated with immune thrombocytopenia purpura in 2 small studies...
  76. ncbi Fc receptor blockade in patients with refractory chronic immune thrombocytopenic purpura with anti-D IgG
    Raúl Ambriz-Fernández
    Banco Central de Sangre, Centro Medico Nacional Siglo XXI CMNSXXI, Instituto Mexicano del Seguro Social IMSS, Mexico City, Mexico
    Arch Med Res 33:536-40. 2002
    This is an evaluation of the treatment of 63 patients with chronic immune thrombocytopenic purpura (54 splenectomized and nine nonsplenectomized) with weekly doses of anti-D (IgG)-coated red blood cells (RBCs).
  77. ncbi Effects of high-dose methylprednisolone therapy on coagulation factors in patients with acute immune thrombocytopenic purpura
    Ahmet Faik Oner
    Department of Pediatric Hematology, Yuzuncu Yil University, Van Turkey
    Clin Appl Thromb Hemost 11:489-92. 2005
    Autoimmune thrombocytopenic purpura (ITP) is a disease that presents with skin and mucous membrane bleeding due to thrombocytopenia...
  78. ncbi An unusual presentation of idiopathic thrombocytopenic purpura in pregnancy
    J Sudharma Ranasinghe
    Department of Anesthesiology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Clin Anesth 17:66-8. 2005
    ..Hematology tests performed before the cesarean delivery revealed severe thrombocytopenia. This was later diagnosed as idiopathic thrombocytopenia, which was treated successfully with steroid therapy...
  79. ncbi Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: a long relapsing and remitting course
    Uzair B Chaudhary
    Department of Medicine, Division of Hematology Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hematol 75:146-50. 2004
    ..Later in the treatment course, dosing of anti-thymocyte globulin (ATG) appeared to have important beneficial contributions in the management of this patient's disease...
  80. ncbi Thrombopoietin mimetic agents in the management of immune thrombocytopenic purpura
    Adrian Newland
    Department of Haematology, Centre for Haematology, The Royal London Hospital, London, UK
    Semin Hematol 44:S35-45. 2007
    ..platelets in healthy subjects and in significant increases in platelets in patients with chronic immune thrombocytopenic purpura (ITP)...
  81. ncbi [Metastatic prostate cancer complicated with chronic disseminated intravascular coagulopathy causing acute renal failure, mimicking thrombotic thrombocytopenic purpura and hemolytic uremic syndrome: pathomechanism, differential diagnosis and therapy relat
    Dániel Deme
    Szent Lázár Megyei Kórház Belgyógyászati Osztály 3100 Salgótarján Füleki út 54 56
    Magy Onkol 54:351-7. 2010
    ..The similar clinical and laboratory findings of TTP-HUS (thrombotic thrombocytopenic purpura - hemolytic uremic syndrome) and DIC makes it difficult to differentiate between them...
  82. ncbi Romiplostim in chronic immune thrombocytopenic purpura
    Robert J Cersosimo
    Department of Pharmacy Practice, Northeastern University School of Pharmacy, Boston, Massachusetts 02115, USA
    Clin Ther 31:1887-907. 2009
    Immune thrombocytopenic purpura (ITP) is characterized by platelet deficiency due to platelet destruction and/or inadequate production. Initial therapy consists of corticosteroids or intravenous immunoglobulin (IVIg)...
  83. ncbi Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome
    Maria Goretti Polito
    Universidade Federal de Sao Paulo, Brazil
    J Bras Nefrol 32:303-15. 2010
    ..Two typical phenotypes of TMAs are hemolytic- uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Other disorders occasionally present with similar manifestations...
  84. ncbi Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/ thrombotic thrombocytopenic purpura (TTP): can we differentiate one from the other?
    Yugo Shibagaki
    Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hypertens Res 28:89-95. 2005
    ..other hand, severe hypertension is sometimes associated with hemolytic uremic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP)...
  85. ncbi Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials
    Mini Michael
    Renal Section Department of Pediatrics, Texas Children s Hospital Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 53:259-72. 2009
    Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are related conditions with similar clinical features of variable severity...
  86. ncbi Treatment options for chronic refractory idiopathic thrombocytopenic purpura in adults: focus on romiplostim and eltrombopag
    Jyoti D Chouhan
    Department of Pharmacy, Scott and White Memorial Hospital and Clinic, Temple, Texas 76508, USA
    Pharmacotherapy 30:666-83. 2010
    Idiopathic thrombocytopenic purpura (ITP) is a platelet disorder that affects approximately 1 in 10,000 people...
  87. ncbi Laparoscopic splenectomy for idiopathic thrombocytopenic purpura
    Bernard Delaitre
    Department of Surgery, Cochin Hospital, Paris, France
    Surg Laparosc Endosc Percutan Tech 12:412-9. 2002
    ..multicenter study by questionnaire to evaluate the results of laparoscopic splenectomy for idiopathic thrombocytopenic purpura (ITP). Between 1991 and 1998, 209 patients with a mean age of 41...
  88. ncbi High-dose plasma infusion versus plasma exchange as early treatment of thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome
    Paul Coppo
    Laboratoire Hématopoïèse et Cellules souches, Institut Gustave Roussy, Villejuif, France
    Medicine (Baltimore) 82:27-38. 2003
    Thrombotic thrombocytopenic purpura and adult hemolytic-uremic syndrome (TTP/HUS) have a substantial mortality rate even with currently available treatments...
  89. ncbi A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: psychometric testing in an open-label clinical trial
    Susan D Mathias
    Ovation Research Group, San Francisco, CA 94105, USA
    Clin Ther 29:950-62. 2007
    The Immune Thrombocytopenic Purpura Patient Assessment Questionnaire (ITP-PAQ) was developed to assess disease-specific quality of life (QoL) in adults with ITP...
  90. ncbi A transforming growth factor-beta1-mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura
    P O Andersson
    Department of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Ann Hematol 79:507-13. 2000
    ..We have studied serum levels of Th cytokines and B- and T-lymphocyte subsets in chronic idiopathic thrombocytopenic purpura (ITP), a disorder in which the production of platelet autoantibodies might be caused by a cytokine ..
  91. ncbi Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention
    C L Bennett
    Institute for Health Services Research and Policy Studies, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Ill, USA
    Arch Intern Med 159:2524-8. 1999
    One of the most unusual causes of thrombotic thrombocytopenic purpura (TTP), a life-threatening disease, is ticlopidine hydrochloride, an antiplatelet agent used to prevent strokes in high-risk populations or following coronary artery ..
  92. ncbi Nine years of cascade filtration for thrombotic thrombocytopenic purpura
    M Valbonesi
    Department of Immunohematology, San Martino University Hospital, Genova, Italy
    Ther Apher Dial 8:87-92. 2004
    Thrombotic thrombocytopenic purpura (TTP) continues to attract physicians' attention because of its unpredictable course and underlying pathogenetic mechanisms...
  93. ncbi Plasma exchange therapy for thrombotic thrombocytopenic purpura in pediatric patients with liver transplantation
    C H Lee
    Division of Nephrology, Liver Transplant Program, Chang Gung Memorial Hosptial Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Transplant Proc 40:2554-6. 2008
    Sporadic cases of thrombotic thrombocytopenic purpura (TTP) have been reported in bone marrow and solid organ transplant patients receiving cyclosporine (CsA)...
  94. ncbi von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
    M Furlan
    Central Hematology Laboratory, University Hospital, Bern, Switzerland
    N Engl J Med 339:1578-84. 1998
    Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet clumping with similar signs and symptoms...
  95. ncbi [Correlation between clinical outcome of 115 patients with idiopathic thrombocytopenic purpura and megakaryocyte counts in bone marrow biopsy]
    Li Yu Zhou
    Hematology Department, Shanghai Jiaotong University, Shanghai Sixth Hospital, Shanghai 200233, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:202-6. 2011
    ..the number of megakaryocytes in bone marrow smear and trephine biopsy on clinical outcome of idiopathic thrombocytopenic purpura (ITP)...
  96. ncbi Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literature
    Marc Michel
    Department of Internal Medicine, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Medicine (Baltimore) 83:254-63. 2004
    To describe the main characteristics and outcome of autoimmune thrombocytopenic purpura (AITP) in patients with common variable immunodeficiency (CVID), we analyzed data from 21 patients and reviewed additional cases from the literature...
  97. ncbi Eltrombopag (75 mg) does not induce photosensitivity: results of a clinical pharmacology trial
    Carolyn J Bowen
    Oncology R and D Unit, GlaxoSmithKline, PO Box 13398, Research Triangle Park, NC 27709 3398, USA
    Photodermatol Photoimmunol Photomed 26:243-9. 2010
    ..thrombopoietin receptor agonist approved in the United States for the treatment of chronic immune thrombocytopenic purpura and under investigation for treatment of thrombocytopenia due to other etiologies...
  98. ncbi Effect of plasma exchange on cytokines measured by multianalyte bead array in thrombotic thrombocytopenic purpura
    Sherry Shariatmadar
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Hematol 79:83-8. 2005
    The serum cytokine profile in thrombotic thrombocytopenic purpura (TTP) has not been extensively characterized...
  99. ncbi Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting
    S R Steinhubl
    Department of Cardiology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Tex 78236 5300, USA
    JAMA 281:806-10. 1999
    Thrombotic thrombocytopenic purpura (TTP) is a rare and often fatal disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, mental status changes, and renal dysfunction...
  100. ncbi Predictors of response after laparoscopic splenectomy for immune thrombocytopenic purpura
    N Katkhouda
    Department of Surgery, Division of Emergency Non Trauma and Minimally Invasive Surgery, University of Southern California School of Medicine, Health Care Consultation Center 514, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Surg Endosc 15:484-8. 2001
    Splenectomy has been shown to produce long term remission in patients with immune thrombocytopenic purpura (ITP). With the development of laparoscopic splenectomy, there is renewed interest in the surgical treatment of ITP...
  101. ncbi Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)
    Christoph Licht
    Department of Pediatric Nephrology and Pediatric Hematology Oncology, University Children s Hospital of Cologne, Cologne, Germany
    Kidney Int 66:955-8. 2004
    Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) are now considered to be variants of one single syndrome called thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)...

Research Grants62

  1. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..The research projects focus on thrombotic thrombocytopenic purpura, systemic lupus erythematosus, and Sj"gren's syndrome, which are also focuses of the Clinical Center...
  2. Determination of a Mechanism for the Thrombocytopenia of WAS
    Ted S Strom; Fiscal Year: 2010
    ..platelet consumption plays a central role in this condition, which has multiple similarities to immune thrombocytopenic purpura (ITP)...
  3. Single molecule measurements on von Willebrand factor A1 and A2 domains
    Timothy A Springer; Fiscal Year: 2013
    ..Inherited or acquired deficiency of ADAMTS13 causes life-threatening thrombotic thrombocytopenic purpura (TTP)...
  4. Molecular Genetic Study of von Willebrand Factor
    David Ginsburg; Fiscal Year: 2013
    ..for 2 related disorders of VWF and FVIII were identified: ADAMTS13 as the cause of familial thrombotic thrombocytopenic purpura (TTP) and MCFD2/LMAN1 as the cause of combined deficiency for factors V and VIII...
  5. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2013
    ..Under certain pathological conditions such as thrombotic thrombocytopenic purpura (TTP), binding of GPIb-IX to circulating ultra-large VWF multimers induces microthrombosis and ..
  6. MOLECULAR GENETICS OF COAGULATION DISORDERS
    David Ginsburg; Fiscal Year: 2013
    ..strain variation to identify additional thrombosis modifiers, as well as modifier genes for thrombotic thrombocytopenic purpura (TTP);(2) continue to explore the critical factors that limit factor VIII expression...
  7. Von Willebrand Factor Multimer Assembly and Structure
    J Evan Sadler; Fiscal Year: 2012
    ..metalloprotease, cleaves VWF multimers at sites of thrombosis, and ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura (TTP)...
  8. MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
    Timothy A Springer; Fiscal Year: 2013
    ..small molecules and macromolecules including fibrinogen and Del-1, and the structural basis for immune thrombocytopenic purpura. Project 2 (Springer) focuses on the molecular basis for rolling and firm adhesion through interaction of ..
  9. Pharmacology and Bioengineering of New Treatment of ITP
    Joseph P Balthasar; Fiscal Year: 2010
    Immune thrombocytopenic purpura (ITP) is a common autoimmune disease that is associated with ~50,000 new cases each year in the United States...
  10. Proteases in the Pathogenesis and Treatment of Thrombosis
    J Evan Sadler; Fiscal Year: 2013
    ..deficiency in thrombotic microangiopathy, and evaluate treatments to prevent relapses in thrombotic thrombocytopenic purpura. Project 2 will employ genomic sequencing to identify defects in complement regulation and hemostasis ..
  11. BIOMECHANICS OF UNFOLDING THE A2 DOMAIN OF VON WILLEBRAND FACTOR
    Jin Yu Shao; Fiscal Year: 2012
    ..On the one hand, insufficient VWF cleavage leads to thrombotic thrombocytopenic purpura, a disease characterized by microvascular thrombosis;on the other hand, excessive cleavage of VWF leads ..
  12. Regulation of von Willebrand Factor Reactivity
    JOSE ARON LOPEZ; Fiscal Year: 2012
    Thrombotic thrombocytopenic purpura (TTP) is a catastrophic and potentially fatal microvascular thrombotic disorder associated with congenital or acquired deficiency of the plasma metalloprotease ADAMTS-13...
  13. Systems Biology of In Vivo Human Blood Cell Populations
    JOHN MATTHEW HIGGINS; Fiscal Year: 2012
    ..types of disease including cancer (leukemia), infection (sepsis), and autoimmune disease (idiopathic thrombocytopenic purpura)...
  14. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2010
    ..Platelet values may drop significantly during chemotherapy and idiopathic thrombocytopenic purpura. During these situations, close and frequent monitoring of a patient's CBC is a must to deliver the ..
  15. Transfusion Medicine/Hemostasis Core Clinical Center
    Thomas L Ortel; Fiscal Year: 2012
    ..In contrast, many hemostatic disorders, such as thrombotic thrombocytopenic purpura (TTP) and hemophilia A patients with inhibitors, are relatively rare, making it difficult to answer ..
  16. Immunoregulatory responses in patients with ITP
    Karina Yazdanbakhsh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Immune thrombocytopenic purpura (ITP) is a bleeding autoimmune disease with accelerated platelet destruction as a result of breakdown of immune tolerance...
  17. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2013
    ..Platelet values may drop significantly during chemotherapy and idiopathic thrombocytopenic purpura. During these situations, close and frequent monitoring of a patient's blood counts is a must to ..
  18. MGH Transfusion Medicine and Hemostasis Network Clinical Core Center
    David J Kuter; Fiscal Year: 2012
    ..transfusion dose of platelets or fresh frozen plasma (FFP) as well as the optimal therapy for immune thrombocytopenic purpura (IIP) and thrombotic thrombocytopenic purpura (TTP) are not understood...
  19. Functional analysis of ADAMTS13
    David G Motto; Fiscal Year: 2010
    ..VWF) and the newly described metalloprotease ADAMTS13 play in pathogenesis of the disease thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency in humans causes TTP...
  20. Forecasters of futute and progressive CDK in patients with microvascular glomerul
    Haifeng M Wu; Fiscal Year: 2013
    ..glomerular injury due to autoimmune disease (lupus nephritis, SLE), thrombotic disease (thrombotic thrombocytopenic purpura, TTP), and metabolic disease (diabetes mellitus, DM)...
  21. Structural bases of ADAMTS-13 and VWF A2 interactions
    Cheng Zhu; Fiscal Year: 2013
    ..Malfunction in the interactions may lead to von Willebrand disease and thrombotic thrombocytopenic purpura. ADAMTS- 13/VWF interaction are regulated mechanically as they take place in the hydrodynamic environment ..
  22. Novel Therapeutics for Acquired Thrombotic Thrombocytopenic Purpura
    X Long Zheng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thrombotic thrombocytopenic purpura (TTP) is a fatal syndrome. Acquired TTP is mainly caused by autoantibodies that inhibit ADAMTS13 enzyme...
  23. Ph 3 of Cyclosporine or Corticosteroids Adjunct to Plasma Exhcange in Tx of TTP
    Haifeng M Wu; Fiscal Year: 2013
    ..Ohio State University (OSU) to build a translational research program in the orphan disease thrombotic thrombocytopenic purpura (TTP)...
  24. Transfusion Medicine/Hemostasis Clinical Research Network
    Keith R McCrae; Fiscal Year: 2012
    ..this period is to continue to evaluate promising new therapies for hemostatic disorders such as immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP), as well as new blood products such as platelets and ..
  25. WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS
    DENISA WAGNER; Fiscal Year: 2007
    ..granules both in homeostasis and in mouse disease models of acute and chronic inflammation, thrombotic thrombocytopenic purpura and stroke. The project will consist of three interrelated Specific Aims...
  26. Mechanical Regulation of Binding and Cleavage of VWF by ADAMTS-13
    Cheng Zhu; Fiscal Year: 2012
    ..new therapeutic approaches to inhibiting pathological platelet adhesion during thrombosis and/or intervention to thrombotic thrombocytopenic purpura (TTP) and/or the bleeding disorder von Willebrand diseases (VWD).
  27. Transfusion Medicine/Hemostasis Clinical Trials Network
    Ellis J Neufeld; Fiscal Year: 2011
    ..thrombopoietin-mimetic agent plus standard care, versus standard care, in children with persistent immune thrombocytopenic purpura (ITP)...
  28. Study of TTP: Incidence Rates and Risk Factors
    Charles Bennett; Fiscal Year: 2005
    Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by a pentad of symptoms including microangiopathic hemolytic anemia (MAHA), thrombocytopenia, neurologic symptoms, fever, and renal dysfunction...
  29. PLATELET AGGLUTINATION IN THROMBOTIC MICROANGIOPATHY
    ERIC LIAN; Fiscal Year: 1993
    ..and thrombotic disorders with emphasis on the thrombotic microangiopathy (TMA), such as thrombotic thrombocytopenic purpura and hemolytic uremic syndrome...
  30. Disease pathophysiology in a murine model of TTP
    David G Motto; Fiscal Year: 2013
    ..a five year research program investigating pathophysiology of the human thrombotic disease thrombotic thrombocytopenic purpura (TTP)...
  31. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
    ..such as stroke, cerebral hemorrhage and cerebral thrombotic complications in disorders such as thrombotic thrombocytopenic purpura (TTP), cerebral malaria, meningitis vascular dementia and Alzheimer's Disease (AD) where localized ..
  32. DRUG ETIOLOGY OF APLASTIC ANEMIA AND RELATED DYSCRASIAS
    David Kaufman; Fiscal Year: 1991
    ..those used for chemotherapy and immunotherapy) in the etiology of aplastic anemia, agranulocytosis, and thrombocytopenic purpura will be continued...
  33. VON WILLEBRAND FACTOR AND THE PATHOPHYSIOLOGY OF TTP
    Joel Moake; Fiscal Year: 1990
    ..are active in clinical and basic research work on the paradigm arterial thrombotic disease, thrombotic thrombocytopenic purpura (TTP)...
  34. Nitric Oxide Donor Compounds for the Treatment of Hemolytic Conditions
    DANIEL KIM SHAPIRO; Fiscal Year: 2009
    ..cell disease and paroxysmal nocturnal hemoglobinuria (PNH), thalassemia intermedia, malaria, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome and cardiopulmonary bypass result in release of Hb into the plasma compartment ..
  35. CHARACTERIZATION OF AUTOANTIBODIES IN IMMUNE CYTOPENIAS
    Denise Shaw; Fiscal Year: 1992
    The etiologies of chronic autoimmune cytopenias like idiopathic thrombocytopenic purpura (AITP) and warm-reactive hemolytic anemia (AIHA) are unknown...
  36. "Development of a Laboratory Test for TTP"
    Christopher Hillyer; Fiscal Year: 2003
    ..application to develop a laboratory test for the diagnosis and monitoring of patients with thrombotic thrombocytopenic purpura (TTP)...
  37. TTP PATHOGENESIS IN MODEL SYSTEMS IN VITRO AND IN VIVO
    David Acheson; Fiscal Year: 1999
    This research proposal is a response to NHLBI RFA HL-95-007 (Thrombotic Thrombocytopenic Purpura (TTP) and HIV)...
  38. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..There are two major clinical phenotypes associated with TMA - hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. These orphan diseases can be triggered by infectious agents, drugs, underlying medical conditions, organ ..
  39. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
    ..system (CNS) injury are life-threatening complications of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura (HUS/TTP). Survivors of HUS/TTP sometimes suffer irreversible damage...
  40. MECHANISMS OF ENDOTHELIAL CELL INJURY IN TTP/HUS
    Jerome Gottschall; Fiscal Year: 1999
    Thrombotic thrombocytopenic purpura (TTP) is a multi-system disorder characterized by micro angiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, and less commonly, fever and renal abnormalities...
  41. PHYSICAL FORCES EFFECTS ON PLATELETS
    J Hellums; Fiscal Year: 2000
    ..involve studies on platelets from normal subjects, as well as on platelets from patients with thrombotic thrombocytopenic purpura (TTP) and other disorders...
  42. THE ENDOTHELIAL CELL IN PATHOGENESIS OF TTP
    Jeffrey Laurence; Fiscal Year: 2004
    ..cell (MVEC) apoptosis plays a key role in the pathophysiology of idiopathic and HIV-associated thrombotic thrombocytopenic purpura (TTP)...
  43. Biological Role of ADAMTS Proteases
    SUNEEL APTE; Fiscal Year: 2007
    ..corresponding roles in disorders such as dermatosparaxis, arthritis, brain tumor invasion and idiopathic thrombocytopenic purpura. However, the biological function of most ADAMTS proteases is not known...
  44. Thrombocytopenia & HIV/HCV: Risk Factors & Treatment
    Kristen Marks; Fiscal Year: 2009
    ..with expertise in patient-oriented research related to HIV infection, HCV infection, and immune thrombocytopenic purpura. Under the supervision of mentors, Drs...
  45. VW Factor Cleaving Prostease and Thrombotic Diseases
    DOMINIC CHUNG; Fiscal Year: 2005
    Thrombotic thrombocytopenic purpura (UP) is a thrombotic microangiopathic disorder that is associated with a deficiency of a protease activity that depolymerizes von Willebrand factor in plasma...
  46. 'AUTOIMMUNE' THROMBOCYTOPENIA
    Nazareth Gengozian; Fiscal Year: 1980
    ..in posttransfusion purpura in man, a hematologic disorder falling within the syndrome of idiopathic thrombocytopenic purpura. The form of platelet (antigen) administration and route of injection are important variables since ..
  47. 2002 Gordon Research Conference on Hemostasis
    David Ginsburg; Fiscal Year: 2002
    ..function of coagulation factors, 4) genetics of inherited bleeding and clotting disorders, 5) thrombotic thrombocytopenic purpura and the ADAMTS13 protease, 6) new therapeutic approaches to the treatment of thrombosis and hemorrhage, 7)..
  48. PLATELET STUDIES IN THROMBOCYTOPENIA
    Wendell Rosse; Fiscal Year: 1991
    We propose to investigate the binding of antibodies to platelets in patients with idiopathic thrombocytopenic purpura, thrombocytopenia with high platelet-bound IgG, drug-induced thrombocytopenia, and alloimmune thrombocytopenia due to ..
  49. A Novel Blood Typing Reagent: Polymeric Anti-Rh IgG
    Koteswara Chintalacharuvu; Fiscal Year: 2001
    ..of the newborn due to Rh incompatibility (Rh-HDN) and for the treatment of idiopathic or HIV-related thrombocytopenic purpura. Using our approach it is possible both to use variable regions of differing specificity and affinity and ..
  50. STUDIES OF PLATELET KINETICS IN MAN USING INDIUM-III
    Min Fu Tsan; Fiscal Year: 1980
    ..We will begin our studies using indium-111 platelets in human disease with a reassessment of the role of the spleen in idiopathic (immune) thrombocytopenic purpura and of platelet kinetics in patients with homocystinuria.
  51. APOPTOSIS OF MICROVASCULAR ENDOTHELIAL CELLS IN HUS
    Jeffrey Laurence; Fiscal Year: 2000
    ..and compared with the effect of plasmas from subsets of patients with a related thrombopathy, thrombotic thrombocytopenic purpura (TTP), who show limited renal pathology...
  52. Development of Soluble FcR-Ig Fusion Proteins
    Leslie Johnson; Fiscal Year: 2004
    ..Idiopathic thrombocytopenic purpura (ITP) is an attractive initial target for an agent blocking the interaction between immune complexes and ..
  53. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  55. IMMUNE CLEARANCE DYSFUNCTION & MURINE AUTOIMMUNE DISEASE
    NANCY MERYHEW; Fiscal Year: 1990
    ..Such studies have direct applicability to autoimmune disease in man, including SLE, immune hemolytic anemia and autoimmune thrombocytopenic purpura.
  56. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  57. STRUCTURE/FUNCTION ANALYSIS OF THE UROKINASE RECEPTOR
    Douglas Cines; Fiscal Year: 2002
    ..abstract_text> ..
  58. DEFENSIN AND THE PATHOGENESIS OF ATHEROSCLEROSIS
    Douglas Cines; Fiscal Year: 2002
    ..Finally, the interaction between endogenous defensin and endogenous Lp(a) will be examined in a novel transgenic mouse than overexpresses both human defensin and human Lp(a). ..
  59. Nuclear translocation of urokinase/nucleolin complexes
    Douglas Cines; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Structure and Function of ADAMTS13 Metalloprotease
    X Long Zheng; Fiscal Year: 2009
    ..of hemostasis and prevention of thrombosis in microvascular circulation that occurs in the thrombotic thrombocytopenic purpura (TTP) syndrome...
  61. ADAMTS13 Deficiency in TTP
    Han Mou Tsai; Fiscal Year: 2008
    Thrombotic thrombocytopenic purpura (TIP), a disease characterized by von Willebrand factor (VWF)- and platelet-rich thrombi in the arterioles and capillaries, typically presents with thrombocytopenia and microangiopathic hemolysis, ..
  62. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    Thrombotic thrombocytopenic purpura (TTP) is a fatal disorder that is characterized by the presence of systemic hyaline thrombi in the arterioles and capillaries. The incidence is estimated to be 4-30 cases/million/year...