aids associated nephropathy

Summary

Summary: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.

Top Publications

  1. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
  2. ncbi Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation
    S J Shankland
    Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle 98195 6521, USA
    Kidney Int 58:674-83. 2000
  3. ncbi Recent progress in HIV-associated nephropathy
    Michael J Ross
    Division of Nephrology, The Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 13:2997-3004. 2002
  4. pmc Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression
    L A Bruggeman
    Divison of Nephrology, Mount Sinai Medical Center, New York 10029, USA
    J Clin Invest 100:84-92. 1997
  5. ncbi HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes
    Mohammad Husain
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 13:1806-15. 2002
  6. ncbi Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies
    L Barisoni
    Department of Pathology, New York University, New York 10016, USA
    Kidney Int 58:137-43. 2000
  7. ncbi HIV dementia: an evolving disease
    Justin C McArthur
    Johns Hopkins University HIV Neurosciences Program, Baltimore, MD, USA
    J Neuroimmunol 157:3-10. 2004
  8. ncbi Resolution of renal failure after initiation of HAART: 3 cases and a discussion of the literature
    Jeffrey T Kirchner
    Comprehensive Care Clinic for HIV, Department of Family and Community Medicine, Lancaster General Hospital, Lancaster, PA, USA
    AIDS Read 12:103-5, 110-2. 2002
  9. ncbi Human immunodeficiency virus/acquired immunodeficiency syndrome-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival in the pre highly active antiretroviral therapy era
    K C Abbott
    Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    J Nephrol 14:377-83. 2001
  10. pmc End-stage renal disease in patients infected with human immunodeficiency virus: a retrospective review of 38 cases
    O O Obayomi
    Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
    J Natl Med Assoc 87:762-5. 1995

Research Grants

  1. Role of KLF15 in podocyte differentiation
    Sandeep Mallipattu; Fiscal Year: 2012
  2. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA'AYAN; Fiscal Year: 2013
  3. APOL1 variants: Understanding the basis of disparities in rates of kidney disease
    Martin R Pollak; Fiscal Year: 2013
  4. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
  5. Role of Protein Acetylation in Diabetic kidney Disease
    John C He; Fiscal Year: 2013
  6. Cell junction proteins in podocyte injury repair
    Jeffrey Simske; Fiscal Year: 2013
  7. Epigenetic factors and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
  8. Molecular Mechanism of APOL1 Associated Kidney Disease
    Martin R Pollak; Fiscal Year: 2013
  9. p66ShcA in HIV associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
  10. Basic FGF Low Affinity Receptors in HIVAN
    Patricio E Ray; Fiscal Year: 2012

Detail Information

Publications222 found, 100 shown here

  1. pmc MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 40:1175-84. 2008
    ..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...
  2. ncbi Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation
    S J Shankland
    Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle 98195 6521, USA
    Kidney Int 58:674-83. 2000
    ..In the current study, we determined the expression and possible role of specific CDK inhibitors in podocyte proliferation in human disease characterized by podocyte injury...
  3. ncbi Recent progress in HIV-associated nephropathy
    Michael J Ross
    Division of Nephrology, The Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 13:2997-3004. 2002
  4. pmc Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression
    L A Bruggeman
    Divison of Nephrology, Mount Sinai Medical Center, New York 10029, USA
    J Clin Invest 100:84-92. 1997
    ..These studies suggest that in humans, a direct effect of HIV-1 expression is likely the essential cause of HIVAN, rather than an indirect effect of cytokine dysregulation...
  5. ncbi HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes
    Mohammad Husain
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 13:1806-15. 2002
    ..These data indicate that Nef induces multiple proliferative effects in podocytes in culture and that nef may therefore be an important gene in the pathogenesis of HIVAN in vivo...
  6. ncbi Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies
    L Barisoni
    Department of Pathology, New York University, New York 10016, USA
    Kidney Int 58:137-43. 2000
    ..Exceptions to this rule are collapsing glomerulopathies (CGs), including HIV-associated nephropathy (HIVAN) and idiopathic CG, where podocytes undergo a dysregulation of their differentiated phenotype and proliferate...
  7. ncbi HIV dementia: an evolving disease
    Justin C McArthur
    Johns Hopkins University HIV Neurosciences Program, Baltimore, MD, USA
    J Neuroimmunol 157:3-10. 2004
    ..relating to HIV-dementia, including: (a) are there differing phenotypes or temporal patterns of progression in HIV-dementia? (b) what determines these temporal patterns? and (c), what has been the impact of therapy on HIV dementia?..
  8. ncbi Resolution of renal failure after initiation of HAART: 3 cases and a discussion of the literature
    Jeffrey T Kirchner
    Comprehensive Care Clinic for HIV, Department of Family and Community Medicine, Lancaster General Hospital, Lancaster, PA, USA
    AIDS Read 12:103-5, 110-2. 2002
    ..We report 3 patients believed to have HIVAN who exhibited marked improvement in renal function after treatment with a regimen comprising 2 nucleoside reverse transcriptase inhibitors and a protease inhibitor...
  9. ncbi Human immunodeficiency virus/acquired immunodeficiency syndrome-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival in the pre highly active antiretroviral therapy era
    K C Abbott
    Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    J Nephrol 14:377-83. 2001
    ..The patient characteristics and course of HlV/AIDS-associated nephropathy (HIVAN) are presented for a national sample of end-stage renal disease (ESRD)...
  10. pmc End-stage renal disease in patients infected with human immunodeficiency virus: a retrospective review of 38 cases
    O O Obayomi
    Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
    J Natl Med Assoc 87:762-5. 1995
    ..Risk factors for HIV infection in these patients were intravenous drug abuse, homosexual behavior, bisexual preference, and blood transfusion. None of these factors consistently influenced the survival of HIV-infected patients with ESRD...
  11. ncbi Human immunodeficiency virus infection and renal failure
    T K Rao
    Renal Diseases Division of the State University of New York, Downstate Medical Center, Brooklyn, New York, USA
    Infect Dis Clin North Am 15:833-50. 2001
    ....
  12. ncbi The clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 63:2295-301. 2003
    ..This study describes the clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis to define the clinical needs of this growing population...
  13. ncbi Predictors of renal outcome in HIV-associated nephropathy
    Frank A Post
    Academic Dept of HIV GUM, King s College London School of Medicine at Guy s, King s College, London, United Kingdom
    Clin Infect Dis 46:1282-9. 2008
    ..This study was performed to study the epidemiology of HIVAN in a predominantly black African population and the impact of highly active antiretroviral therapy and other factors on the development of end-stage renal disease...
  14. ncbi Renal disease in patients with HIV infection: epidemiology, pathogenesis and management
    Derek M Fine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Drugs 68:963-80. 2008
    ..Only with greater awareness of kidney-disease manifestations and their implications in this particularly vulnerable population will we be able to achieve success in confronting this growing problem...
  15. ncbi HIV-1 and HIV-Associated Nephropathy 25 Years Later
    Christina M Wyatt
    Mount Sinai School of Medicine, Box 1243, One Gustave L Levy Place, New York, NY 10029
    Clin J Am Soc Nephrol 2:S20-4. 2007
    ..This article reviews the history of HIV and HIVAN, focusing on advances in the understanding of pathogenesis, epidemiology, and treatment...
  16. ncbi HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management
    Mohamed G Atta
    Expert Rev Anti Infect Ther 6:365-71. 2008
    ..Furthermore, HAART, corticosteroids and inhibition of the renin-angiotensin axis are potentially helpful in delaying disease progression, as well as the need for renal replacement therapy...
  17. ncbi Unusual presentations of primary human immunodeficiency virus infection
    Susan Szabo
    HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899 1668, USA
    AIDS Patient Care STDS 16:251-4. 2002
    ..Serologic testing demonstrated HIV seroconversion. Clinicians need to have a high index of suspicion when evaluating patients even when risk behaviors are not readily apparent...
  18. ncbi The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 66:1145-52. 2004
    ..This study was undertaken to compare HIVAN to the spectrum of other kidney diseases seen among HIV-infected patients...
  19. ncbi Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol
    Peter J Nelson
    Division of Nephrology, Box 1243, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Antimicrob Chemother 51:921-9. 2003
    ..These results demonstrate for the first time that targeting the cyclin-dependent kinases that support HIV-1 expression can ameliorate HIV-induced disease in an animal model...
  20. ncbi [The methods of therapy ESRD patients infected with the human immunodeficiency virus-HIV]
    Jolanta Gozdowska
    Klinika Medycyny Transplantacyjnej i Nefrologii Instytutu Transplantologii AM w Warszawie
    Przegl Lek 65:82-6. 2008
    ..In this article authors present the general information about HIV infection (epidemiology, diagnosis and treatment) as well as methods of therapy ESRD like hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation...
  21. ncbi Human immunodeficiency virus-associated nephropathy
    Chun Fu Lai
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Formos Med Assoc 105:680-4. 2006
    ..In summary, this case of HIVAN in a Taiwanese patient shows that the condition may progress to ESRD despite successful viral suppression with HAART...
  22. ncbi Solid organ transplantation in HIV-infected recipients
    Suzanne El Sayegh
    Division of Nephrology, Mount Sinai School of Medicine, New York 10029, USA
    Pediatr Transplant 8:214-21. 2004
    ..In this article We review the literature to date in liver and renal transplantation, including more recent data in patients receiving HAART...
  23. doi Kidney biopsy in HIV: beyond HIV-associated nephropathy
    Derek M Fine
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 51:504-14. 2008
  24. ncbi The clinical characteristics of HIV-infected patients receiving dialysis in France between 1997 and 2002
    Cecile Vigneau
    Department of Nephrology A, Tenon Hospital, Paris, France
    Kidney Int 67:1509-14. 2005
    ..In 1997, 0.38% of dialysis patients in France were infected by human immunodeficiency virus (HIV). No prevalence data were available in France since the widespread introduction of highly active antiretroviral therapy...
  25. ncbi HIV-associated nephropathy: Epidemiology, pathogenesis, and treatment
    Elizabeth S Herman
    Division of Nephrology, Mount Sinai Medical Center, New York, NY, USA
    Semin Nephrol 23:200-8. 2003
    ....
  26. ncbi HIV-1 infection and the kidney: an evolving challenge in HIV medicine
    Thushan I de Silva
    Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, L Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    Mayo Clin Proc 82:1103-16. 2007
    ..Host factors may modify disease expression at the level of cytokine networks and the renal microvasculature and contribute to the pathogenic effects of HIV-1 infection on the kidney...
  27. ncbi [Problem of HIV-infected patients receiving dialysis]
    Andrzej Steciwko
    Katedra i Zakład Medycyny Rodzinnej, Akademia Medyczna we Wrocławiu
    Przegl Lek 61:185-91. 2004
    ..We present also algorithms of management with patient with acute/chronic renal failure in dependence on result of HIV test...
  28. ncbi The impact of HIV on chronic kidney disease outcomes
    A I Choi
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
    Kidney Int 72:1380-7. 2007
    ..HIV-infected white patients experienced higher rates of death but a lower risk of ESRD than their counterparts with diabetes. Our results highlight a need to study mortality and mechanisms of ESRD in the HIV infected population...
  29. ncbi Critical role for Nef in HIV-1-induced podocyte dedifferentiation
    Masaaki Sunamoto
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 64:1695-701. 2003
    ..These data suggest that Nef induces many of the changes we observe in HIV transgenic model and, as a result, this now defines the pathway for exploration of host responses to HIV-1 infection...
  30. ncbi Antiretroviral drugs and the kidney: dosage adjustment and renal tolerance
    Hassane Izzedine
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Curr Pharm Des 10:4071-9. 2004
    ..6 to 1%). Therefore, administration of antiretroviral drugs in human immunodeficiency virus (HIV) patients with nephropathy is not uncommon...
  31. ncbi Highly active antiretroviral therapy and the incidence of HIV-1-associated nephropathy: a 12-year cohort study
    Gregory M Lucas
    Johns Hopkins University, Baltimore and the Good Samaritan Hospital, Baltimore, Maryland, USA
    AIDS 18:541-6. 2004
    ..to assess temporal changes in the incidence of human immunodeficiency virus-1-associated nephropathy (HIVAN), and the association with use of highly active antiretroviral therapy (HAART)...
  32. ncbi End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004
    Gregory M Lucas
    Department of Medicine, Divisions of Infectious Diseases, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, USA
    AIDS 21:2435-43. 2007
    ..HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT)...
  33. ncbi [Henoch-Schönlein purpura nephritis in a patient infected with the human immunodeficiency virus]
    Hiromi Hidaka
    Department of Nephrology, Tokyo Medical University, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 45:387-92. 2003
    ..After a year, urinary protein was negative, but mild microhematuria persisted. We speculate that the refractory nephrotic syndrome in this patient might be associated with the abnormal immunological condition due to HIV infection...
  34. ncbi Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy
    Michael D Ross
    Department of Medicine, Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:33248-55. 2003
    ..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN...
  35. ncbi BK virus-associated renal failure among HIV patients
    Nancy Crum-Cianflone
    AIDS 21:1501-2. 2007
  36. ncbi Genetic susceptibility, HIV infection, and the kidney
    Krzysztof Kiryluk
    Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Clin J Am Soc Nephrol 2:S25-35. 2007
    ....
  37. pmc Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 18:93-102. 2007
    ..These results demonstrate the mechanism by which atRA reverses the proliferation of podocytes that is induced by HIV-1...
  38. ncbi Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathy
    Peter Dickie
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Virology 322:69-81. 2004
    ..However, the unique contribution of macrophage-specific Vpr expression in the development of glomerular disease was underscored by the induction of FGS in multiple murine lines bearing a c-fms/vpr transgene...
  39. ncbi Kidney transplants in HIV patients?
    Tracy Coleman
    Hahnemann University Hospital, Philadelphia, USA
    RN 69:33-8; quiz 39. 2006
  40. ncbi [HIV-1 and renal cells: pathogenesis of HIV-associated nephropathy]
    P G Conaldi
    Laboratorio di Virologia, Dipartimento di Medicina e Sanita Pubblica, Universita dell Insubria, Varese, Italy
    G Ital Nefrol 22:569-80. 2005
    ....
  41. ncbi A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South Africa
    T M Han
    Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Kidney Int 69:2243-50. 2006
    ..This will allow diagnosis and treatment of HIVAN at an early stage and may prevent further disease progression...
  42. ncbi Improved survival in HIV-infected African-Americans with ESRD
    J MacRae
    Department of Medicine, Box 50, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Clin Nephrol 64:124-8. 2005
    ..To determine if there has been improvement in survival of HIV-infected patients with end-stage renal failure subsequent to widespread use of highly active antiretroviral therapy...
  43. ncbi HIV-associated renal diseases and highly active antiretroviral therapy-induced nephropathy
    J Roling
    Department of Infectious Diseases, Medizinische Poliklinik, Ludwig Maximilians Universitat, University of Munich, Munich, Germany
    Clin Infect Dis 42:1488-95. 2006
    ..In this article, we review the current knowledge about acute and chronic HIV-associated renal disease, metabolic alterations and related nephropathies, and toxic drug effects of combination antiretroviral pharmacotherapy...
  44. ncbi Viral load and HIV-associated nephropathy
    Hassane Izzedine
    N Engl J Med 353:1072-4. 2005
  45. ncbi HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells
    Michael J Ross
    Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Acquir Immune Defic Syndr 42:1-11. 2006
    ..These studies provide novel insights into the mechanisms by which HIV-1 infection of tubular epithelial cells leads to tubulointerstitial inflammation and progressive renal injury...
  46. ncbi Absence of HIV-associated nephropathy in Ethiopians
    Doron M Behar
    Department of Critical Care Medicine, The Bruce Rappaport Faculty of Medicine and Research Institute, Haifa, Israel
    Am J Kidney Dis 47:88-94. 2006
    ..Accordingly, we sought to determine whether a similar or different pattern of susceptibility was evident among Ethiopians followed up in an HIV clinic in Israel...
  47. ncbi HIV-2 infection and HIV-associated nephropathy
    Hassane Izzedine
    AIDS 20:949-50. 2006
  48. ncbi Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model
    Noriyuki Hiramatsu
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Am Soc Nephrol 18:515-27. 2007
    ..AT1R blockade could be beneficial in the treatment of HIVAN by ameliorating podocyte injury by avoiding the vicious cycle of nephron reduction and glomerular hypertension...
  49. ncbi Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reaction
    N Tanji
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, USA
    Histol Histopathol 21:393-401. 2006
    ..IS-PCR is a powerful technique to detect viral DNA in human tissue sections, but requires proper use of negative controls to set optimal fixation, protein digestion, and amplification conditions...
  50. ncbi HIV/AIDS--dominant player in chronic kidney disease
    Saraladevi Naicker
    Division of Nephrology, University of the Witwatersrand, Johannesburg Hospital Area 551, 7 York Road, Parktown, Johannesburg 2193, South Africa
    Ethn Dis 16:S2-56-60. 2006
    ..Preventive strategies need to be determined; prospective studies including antiretroviral therapy, angiotensin-converting enzyme inhibitors, and other therapeutic agents are required...
  51. ncbi Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease
    Michael J Ross
    Mount Sinai School of Medicine, Division of Nephrology, Box 1243, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 17:996-1004. 2006
    ..These results suggest a novel role for FAT10 in epithelial apoptosis, which is an important component of the pathogenesis of many renal diseases...
  52. pmc NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy
    Michael J Ross
    Division of Nephrology, Mount Sinai Medical Center, New York, New York, USA
    J Am Soc Nephrol 16:2403-11. 2005
    ..These results suggest that NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium...
  53. ncbi Asymptomatic HIV patient with cardiomyopathy and nephropathy: case report and literature review
    S C Tayal
    Department of Genito-Urinary Medicine, Middlesbrough General Hospital, Ayresome Green Lane, Middlesbrough, Cleveland TS5 5AZ, UK
    J Infect 42:288-90. 2001
    ..An understanding of the spectrum of renal and cardiac derangements is essential for clinicians in managing patients with HIV disease...
  54. ncbi Antiretroviral therapy in the treatment of HIV-associated nephropathy
    Mohamed G Atta
    Department of Medicine, Division of Nephrology, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
    Nephrol Dial Transplant 21:2809-13. 2006
    ..This study was undertaken to further elucidate the potential benefit of ART in HIV-infected patients with documented HIVAN...
  55. ncbi Treatment of HIV-associated nephropathy
    R Sothinathan
    Division of Nephrology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    AIDS Patient Care STDS 15:363-71. 2001
    ..Appropriate randomized controlled trials are urgently required in order to further examine the efficacy, optimal timing, and potential side effects of these treatments...
  56. ncbi Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease
    Elissa J Schwartz
    Division of Nephrology, Mount Sinai Medical Center, New York, NY 10029, USA
    J Am Soc Nephrol 16:2412-20. 2005
    ..It is concluded that prevention of progression to ESRD should focus on early antiretroviral treatment of HIV-infected patients who have evidence of HIV-associated nephropathy...
  57. ncbi [Acute tubulointerstitial nephritis in HIV infection]
    M Moddel
    Nephrologische Abteilung der Medizinischen Klinik, Stadtspital Waid Zürich
    Praxis (Bern 1994) 95:949-51. 2006
    ..After discontinuing medication with atazanavir serum creatinine level decreased spontaneously without steroids. The different etiologies of acute renal failure in patients with human immunodeficiency infection are discussed...
  58. ncbi HIV-associated renal diseases in Africa a desperate need for additional study
    Scott D Cohen
    Nephrol Dial Transplant 22:2116-9. 2007
  59. ncbi Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection?
    Alexandros B Tsoupras
    University of Athens, Faculty of Chemistry, Athens, Greece
    AIDS Res Hum Retroviruses 24:1079-86. 2008
    ..These promising results need to be further studied and confirmed by additional in vivo tests in order to optimize HAART efficacy...
  60. ncbi The urological management of the patient with acquired immunodeficiency syndrome
    Chris F Heyns
    Department of Urology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
    BJU Int 95:709-16. 2005
    ..After occupational exposure to HIV, chemoprophylaxis with antiretroviral medication can significantly reduce the probability of HIV transmission...
  61. ncbi Chronic kidney disease in human immunodeficiency virus infection
    J Fabian
    Division of Nephrology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Panminerva Med 49:51-66. 2007
    ..An integrated plan to reduce the progression to kidney failure together with lifestyle measures, focusing also on high risk groups with effective management at all levels of chronic kidney disease remains essential...
  62. pmc Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15
    George W Nelson
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Hum Mol Genet 19:1805-15. 2010
    ..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
  63. ncbi Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy
    Mohamed G Atta
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Med 118:1288. 2005
    ....
  64. ncbi Renal cytomembranous inclusions in idiopathic renal disease as predictive markers for the acquired immunodeficiency syndrome
    P Chander
    Department of Pathology, New York Medical College, Valhalla 10595
    Hum Pathol 19:1060-4. 1988
    ..These structures may be of predictive value for the future development of AIDS in patients presenting with apparent idiopathic renal disease...
  65. ncbi Course and prognosis of human immunodeficiency virus-associated nephropathy
    L Carbone
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
    Am J Med 87:389-95. 1989
    ..Patient survival is dependent upon the stage of HIV infection. These findings may prove useful in devising more effective strategies for the care of this growing patient population...
  66. ncbi Transforming growth factor beta increases the expression of HIV-1 gene in transfected human mesangial cells
    R R Shukla
    Department of Molecular Biology, George Washington University Medical Center, Washington, D C
    Kidney Int 44:1022-9. 1993
    ..We further studied whether up-regulation of HIV-1 LTR expression in HMC was mediated by the effect of TGF-beta on the interaction of transcription factors to their binding sites.(ABSTRACT TRUNCATED AT 250 WORDS)..
  67. ncbi Renal effects of angiotensin-converting enzyme inhibitors that result in cost savings and improved patient outcomes
    A L Swislocki
    Medical Service 111, Department of Veterans Affairs NCHCS, 150 Muir Road, Martinez, CA 94553, USA
    Am J Manag Care 7:283-95. 2001
    ..Many questions remain about the categories of patients that benefit from ACE inhibitor use...
  68. ncbi Cyclin-dependent kinases as cellular targets for antiviral drugs
    Luis M Schang
    Department of Biochemistry, Signal Transduction Research Group, University of Alberta, 315C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    J Antimicrob Chemother 50:779-92. 2002
    ....
  69. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
    ....
  70. ncbi Renal manifestations in HIV-infected Jamaican children
    J Steel-Duncan
    Department of Obstetrics, Gynaecology and Paediatrics, The University of the West Indies, Kingston 7, Jamaica
    West Indian Med J 57:246-52. 2008
    ..With increased public access to antiretroviral therapy since 2002 and subsequent survival, renal complications are increasingly recognized among the surviving cohort of infected children...
  71. ncbi Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient
    Derek M Fine
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Semin Nephrol 28:545-55. 2008
    ..As a consequence of establishing an accurate diagnosis, improved patient outcome can best be accomplished through disease-specific intervention...
  72. pmc HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein
    Ting Chi Lu
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 283:8173-82. 2008
    ..We conclude that in HIV-infected podocytes, Nef, through the recruitment of DIP and p190RhoAGAP to Nef-Src complex, activates p190RhoAGAP and down-regulates RhoA activity...
  73. ncbi Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
    A A Kapasi
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 280:F333-42. 2001
    ..These results suggest that HIV-1 gp 120 induces alterations in conflicting survival signaling pathways that contribute to the potential dual effects of gp 120 in promoting or inhibiting HMC proliferation...
  74. ncbi Nef modulation of HIV type 1 gene expression and cytopathicity in tissues of HIV transgenic mice
    P Dickie
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    AIDS Res Hum Retroviruses 16:777-90. 2000
    ..This HIV proviral transgenic model has demonstrated the capacity of HIV-1 Nef to contribute to HIV cytopathicity by altering cellular maturation and viral gene expression in vivo...
  75. ncbi Correlation of CD4 counts with renal disease in HIV positive patients
    Hari Janakiraman
    Department of Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, India
    Saudi J Kidney Dis Transpl 19:603-7. 2008
    ..We conclude that our study demonstrates that both proteinuria and HIVAN are common in HIV infected patients. Proteinuria has a negative correlation with the CD4 counts and hemoglobin levels...
  76. ncbi Renal involvement in patients infected with HIV: experience at San Francisco General Hospital
    S A Mazbar
    Division of Nephrology, San Francisco General Hospital, California
    Kidney Int 37:1325-32. 1990
    ..We also reviewed 91 consecutive autopsies performed in patients dying with AIDS at SFGH between 1981 and 1986.(ABSTRACT TRUNCATED AT 250 WORDS)..
  77. ncbi HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical properties
    R Tandon
    Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Physiol Renal Physiol 292:F701-10. 2007
    ..The mechanical properties of the WT podocytes suggest that these cells can better maintain capillary integrity than the HIVAN podocytes and implicate pathological assembly of the cytoskeleton as a mechanism of HIVAN...
  78. ncbi Impact of highly active antiretroviral therapy on organ-specific manifestations of HIV-1 infection
    D Torre
    Department of Infectious Diseases, General Hospital and Macchi Foundation, Varese, Italy
    HIV Med 6:66-78. 2005
    ....
  79. pmc HIV associated nephropathy: a treatable condition
    M G Brook
    Patrick Clements Clinic, Department of GUM HIV, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK
    Sex Transm Infect 77:97-100. 2001
    ..To describe current knowledge on the aetiology, pathology, diagnosis, and treatment of HIV associated nephropathy...
  80. ncbi Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy
    Daniele Marras
    Division of Nephrology, Department of Medicien, Mount Sinai School of Medicine, New York, New York, USA
    Nat Med 8:522-6. 2002
    ..These data, along with the detection of HIV-1-specific proviral DNA and mRNA in tubular epithelium cells, argue strongly for localized replication of HIV-1 in the kidney and the existence of a renal viral reservoir...
  81. ncbi Outcome of patients with human immunodeficiency virus on maintenance hemodialysis
    C Ortiz
    Department of Medicine, University of Miami School of Medicine, Florida
    Kidney Int 34:248-53. 1988
    ..In asymptomatic HIV carriers and in patients with ARC, however, maintenance hemodialysis provides meaningful, long-term life support...
  82. ncbi Association of parvovirus B19 infection with idiopathic collapsing glomerulopathy
    A Moudgil
    Department of Pediatrics, Division of Transplant Immunology, Steven Spielberg Pediatric Research Center, UCLA School of Medicine, Los Angeles, California, USA
    Kidney Int 59:2126-33. 2001
    ..We previously reported a renal transplant recipient with de novo CG and red cell aplasia in association with persistent parvovirus B19 (PVB19) infection. This prompted us to look for an association between PVB19 infection and CG...
  83. ncbi Glomerular lesions in HIV-positive patients: a 20-year biopsy experience from Northern Italy
    M Nebuloni
    L Sacco Department Clinical Sciences, L Sacco Hospital, University of Milan, Milan, Italy
    Clin Nephrol 72:38-45. 2009
    ..Moreover, in the group of non-HIVAN patients, the possible differences in histological characteristics from non-HIV lesions were investigated...
  84. ncbi CKD in HIV-infected patients other than HIV-associated nephropathy
    Ajay K Rachakonda
    Division of Kidney Urologic and Hematologic Diseases, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, USA
    Adv Chronic Kidney Dis 17:83-93. 2010
    ..The results of treating kidney disease in HIV-infected patients remain unclear, and properly designed randomized controlled trials of the treatment of ICGN with HAART and other approaches are desperately needed...
  85. ncbi HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN
    Mohammad Husain
    Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    AIDS 19:1975-80. 2005
    ..To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy...
  86. ncbi Renal pathology and HIV infection in Thailand
    K Praditpornsilpa
    Department of Medicine, Police General Hospital, Bangkok, Thailand
    Am J Kidney Dis 33:282-6. 1999
    ..Although the data in this study are limited to 26 HIV-infected Thai patients, we believe that HIVAN is uncommon in the Asian HIV-infected population...
  87. pmc HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation
    P G Conaldi
    Division of Microbiology, Department of Clinical and Biological Sciences, University of Insubria, Varese 21100, Italy
    J Clin Invest 102:2041-9. 1998
    ..These findings may explain the prominent histopathology of HIV-associated nephropathy and demonstrate that the apoptosis of nonlymphoid cells can be directly induced by HIV-1...
  88. ncbi An uncommon glomerular disease in an HIV patient: value of renal biopsy and review of the literature
    C Chen
    Department of Medicine, Tufts Medical Center, Boston, MA, USA
    Clin Nephrol 75:80-8. 2011
    ..We report another case of ITG in an HCV- and HBV-negative, AA female...
  89. ncbi Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes
    P J Nelson
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Soc Nephrol 12:2827-31. 2001
    ..Thus, suppression of HIV-1 transcription by selective cyclin-dependent kinase-9 inhibitors may be a useful therapeutic strategy for the treatment of HIVAN...
  90. ncbi APOBEC3G expression is restricted to epithelial cells of the proximal convoluted tubules and is not expressed in the glomeruli of macaques
    M Sarah Hill
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Histochem Cytochem 55:63-70. 2007
    ....
  91. pmc Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    John Cijiang He
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 114:643-51. 2004
    ..These data suggest that Nef-induced activation of Stat3 and Ras-MAPK1,2 via Src-dependent pathways is responsible for podocyte proliferation and dedifferentiation, a characteristic finding in collapsing FSGS of HIVAN...
  92. ncbi Lupus-like nephritis in an HIV-positive patient: report of a case and review of the literature
    D Tabechian
    Division of Allergy lmmunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Nephrol 60:187-94. 2003
    ..Considering previously reported cases, it appears that lupus-like nephritis is a rare but well-defined pattern of immune-complex-induced renal injury seen in HIV-infected patients. It appears to be markedly responsive to HAART...
  93. ncbi Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infection
    Christina M Wyatt
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Expert Opin Drug Saf 5:275-87. 2006
    ....
  94. pmc Activation of Notch signaling pathway in HIV-associated nephropathy
    Madhulika Sharma
    Department of Anatomy and Cell Biology and The Kidney Institute, University of Kansas Medical Center, Kansas City, USA
    AIDS 24:2161-70. 2010
    ..To determine whether Notch signaling is involved in renal disorder associated with HIVAN, we evaluated the expression of Notch receptors in HIVAN...
  95. ncbi [Secondary glomerular nephropathies]
    Philippe Lesavre
    Service de néphrologie et INSERM U507, Hopital Necker, 75743 Paris Cedex 15
    Rev Prat 53:2039-48. 2003
    ....
  96. ncbi Immunotactoid glomerulopathy in an HIV-positive African-American man
    Jeffrey L Martin
    Hypertension and Kidney Specialists of Lancaster, Lancaster, PA 17543, USA
    Am J Kidney Dis 42:E6-10. 2003
    ..This case emphasizes the diverse glomerular lesions seen in HIV-positive patients and supports the use of renal biopsy to establish a diagnosis...
  97. ncbi Clinical and basic science advances in the treatment of HIV-1 and its associated kidney disease
    A Sethi
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Minerva Urol Nefrol 61:439-54. 2009
    ..Emphasis is placed on early diagnosis and timely treatment of kidney disease and heightened awareness particularly among the vulnerable population that bears most of the disease burden...
  98. ncbi Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteries
    Guillaume Canaud
    Universite Paris Descartes, Paris, France
    Am J Kidney Dis 55:558-65. 2010
    ..Together, these data suggest that acute glomerular ischemia may lead to glomerular collapse in kidney transplants...
  99. pmc Controversies in the pathogenesis of HIV-associated renal diseases
    Leslie A Bruggeman
    Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Nat Rev Nephrol 5:574-81. 2009
    ..Rodent HIV-1 models, for instance, cannot replicate all features of immune activation, a process that could have an important role in the pathogenesis of the HIV-associated renal diseases...
  100. ncbi [Post-infectious glomerulonephritis]
    G Barbiano di Belgiojoso
    U O Nefrologia e Dialisi, Azienda Ospedaliera Polo Universitario Luigi Sacco, Milano, Italy
    G Ital Nefrol 20:184-99. 2003
    ..Among the rare viral infections, we ultimately, mention the association between Parvovirus B19 and "collapsing" focal segmental glomerulosclerosis...
  101. ncbi Prevalence and clinical characteristics of HIV type 1-infected patients receiving dialysis in Spain: results of a Spanish survey in 2006: GESIDA 48/05 study
    J C Trullas
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 24:1229-35. 2008
    ..05). The prevalence of HIV infection in Spanish dialysis units in 2006 was 0.54% HCV coinfection was very frequent (61%) and the percentage of patients included on the Spanish RT waiting list was low (12%)...

Research Grants52

  1. Role of KLF15 in podocyte differentiation
    Sandeep Mallipattu; Fiscal Year: 2012
    ..abstract_text> ..
  2. Role of HIPK2 in Kidney Tubulointerstitial Injury
    AVI MA'AYAN; Fiscal Year: 2013
    ....
  3. APOL1 variants: Understanding the basis of disparities in rates of kidney disease
    Martin R Pollak; Fiscal Year: 2013
    ..We ask whether these molecules alter APOL1 biology in vitro, and whether biochemical levels of these mediators predict which individuals with the APOL1 risk genotype are likely to develop kidney disease. ..
  4. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
    ..This will benefit individuals at risk who could benefit from therapeutic intervention to alleviate disease at an earlier stage. The anticipated benefits to the population at large outweigh the minimal risk involved in the study. ..
  5. Role of Protein Acetylation in Diabetic kidney Disease
    John C He; Fiscal Year: 2013
    ..The proposed studies will help us to understand how acetylation of TFs affects their target gene expression in diabetic kidneys and determine whether BrDi could be developed as a new class of drugs to treat patients with DKD. ..
  6. Cell junction proteins in podocyte injury repair
    Jeffrey Simske; Fiscal Year: 2013
    ..These studies will have important implications toward the development of novel therapies directed at glomerular diseases characterized by foot processes effacement where preventing or repairing damaged podocytes would be beneficial. ..
  7. Epigenetic factors and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
    ....
  8. Molecular Mechanism of APOL1 Associated Kidney Disease
    Martin R Pollak; Fiscal Year: 2013
    ..We will also define the specific interactions between the wild-type, G1, and G2 forms of ApoL1 in vivo. Lastly, we will examine the role of ApoL1 variants in promoting or preventing apoptosis of glomerular cells. ..
  9. p66ShcA in HIV associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
    ..At present, there is no specific treatment to cure this disease. Our long term research goal is to develop strategies to slow down the progression and/or cure of this devastating kidney disease. ..
  10. Basic FGF Low Affinity Receptors in HIVAN
    Patricio E Ray; Fiscal Year: 2012
    ....
  11. Renin Angioensin Aldosterone System in Drub Abuse and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2013
    ..Based on our preliminary data, we hypothesize that modulation of RAAS by its selective inhibitors will not only prevent or attenuate HIV-1- induced renal injury but also delay or slow down the progression of HIVAN. ..
  12. RNA profiling of HIV-associated nephropathy in patients with the MYH9 risk allele
    PAUL EVAN KLOTMAN; Fiscal Year: 2010
    ..Findings from the proposed research are likely to provide insights into the increased susceptibility to kidney disease and end-stage renal disease among people of African descent. ..
  13. Kidney disease mechanisms associated with human genetic variation
    John R Sedor; Fiscal Year: 2012
    ....
  14. Program Project: The Pathogenesis of HIV-Associated Nephropathy
    PAUL EVAN KLOTMAN; Fiscal Year: 2013
    ..Results from these studies will provide improved understanding of HIVAN pathogenesis, AIDS pathogenesis, appropriate strategies for therapy, and insights into renal disease susceptibility of Blacks in general. ..
  15. MULTIPHOTON LASER SCANNING MICROSCOPE
    VICTOR LOUIS FRIEDRICH; Fiscal Year: 2010
    ....
  16. HIV ASSOCIATED NEPHROPATHY IN CHILDREN
    JOSE STRAUSS; Fiscal Year: 1993
    ..An effort will also be made to identify certain clinical indicators which can predict the development of, or correlate with the severity of, the renal disease...
  17. Improving Annenberg 23 in Support of Translational Research
    Dennis S Charney; Fiscal Year: 2010
    ....
  18. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
    ..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
  19. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
  20. EPIDEMIOLOGY AND CLINICAL COURSE OF HIV NEPHROPATHY
    Lynda Anne Szczech; Fiscal Year: 2004
    ....
  21. Sidekick proteins in HIV-associated nephropathy
    Lewis Kaufman; Fiscal Year: 2009
    ..These studies should elucidate the mechanisms by which sdk-1 contributes to podocyte dysfunction in HIVAN. ..
  22. Transgene Induced HIV-Associated Nephropathy
    Vincent Gattone; Fiscal Year: 2004
    ..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
  23. VEGF in podocyte injury induced by HIV
    Sonal Shah; Fiscal Year: 2006
    ..Also, we hope to investigate whether VEGF inhibitors can improve the kidney disease in HIV-1 (TG26) transgenic mice as this could open up a new avenue in the treatment of HIV. [unreadable] [unreadable] [unreadable]..
  24. Iron and Vitamin E in Childhood HIV-Associated Renal Disease
    Patricio Ray; Fiscal Year: 2006
    ..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. [unreadable] [unreadable]..
  25. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ....
  26. Epithelial gene expression in HIV-associated nephropathy
    Michael Ross; Fiscal Year: 2006
    ..It is also possible that genes implicated in the pathogenesis of HIVAN maybe important factors contributing to the marked predisposition of African-Americans to nearly all causes of renal failure. ..
  27. FAT10 a candidate gene for epithelial apoptosis in HIV-associated nephropathy
    Michael Ross; Fiscal Year: 2007
    ..These studies will advance our understanding of HIVAN pathogenesis and may yield a novel therapeutic target for the treatment of HIVAN and other renal diseases. [unreadable] [unreadable]..
  28. The Prevalence, Pathogenesis And Therapy of HIVAN
    Jonathan Winston; Fiscal Year: 2006
    ..The award is structured to allow me to intensify my efforts in clinical research, develop new research skills through postgraduate work, and mentor trainees in clinical epidemiology, clinical trials and outcomes research. ..
  29. PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2008
    ..Specific Aim 4 will examine the effects of these interventions on systemic cryoglobulinemia. It is anticipated that the findings will lead to better treatments for cryoglobulinemia and associated MPGN. ..
  30. Biotechnology Center for Comparative Genomics
    CHARLES ALPERS; Fiscal Year: 2003
    ..abstract_text> ..
  31. PATHOGENESIS OF HIV ASSOC THROMBOTIC MICROANGIOPATHY
    CHARLES ALPERS; Fiscal Year: 2003
    ..abstract_text> ..
  32. Effect of Alcohol on SHIV Neuroinvasion
    Edward Stephens; Fiscal Year: 2004
    ..The results of these studies should provide direct evidence on the effect of ethanol on primate lentivirus neuroinvasion and neuropathogenesis. ..
  33. Pathogenesis of HIVAN: the role of Nef
    JOHN HE; Fiscal Year: 2007
    ..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
  34. SHIV ASSOCIATED ENCEPHALOPATHY
    Edward Stephens; Fiscal Year: 2003
    ..It is anticipated that the proposed studies will provide valuable information which will improve our understanding of HIV-1 neuropathogenesis. ..
  35. PDGF-D INDUCED MODELS OF MESANGIAL GLOMERULOPATHY
    CHARLES ALPERS; Fiscal Year: 2005
    ..abstract_text> ..
  36. RAGE and Glomerulosclerosis
    VIVETTE D AGATI; Fiscal Year: 2007
    ..We propose that identification of RAGE-dependent mechanisms in glomerular diseases may lead to novel therapies to prevent, stabilize or reverse the course of chronic GS. ..
  37. Directly observed antiretroviral therapy in drug abusers
    GREGORY LUCAS; Fiscal Year: 2006
    ..My career plan and research proposal are consistent with my long-term goals of becoming an effective independent investigator, and optimizing treatment outcomes in HIV-infected IDUs. ..
  38. A New DNA Vaccine Against HIV Disease in Macaques
    Edward Stephens; Fiscal Year: 2008
    ..Vaccine boosts will continue after drug therapy had been withdrawn. These studies will be applicable to HIV infected persons under HAART. ..
  39. Role of Targeted Mutations in ViF on SHIV Pathogenesis
    Edward Stephens; Fiscal Year: 2006
    ..The proposed studies will provide new information on the role of this Vif motif in pathogenesis using a relevant macaque model. ..
  40. Directly Administered HIV Therapy in Methadone Clinics
    GREGORY LUCAS; Fiscal Year: 2009
    ..Our research team has an established history of collaboration in this area, and brings together a wealth of research expertise in HIV treatment outcomes, substance abuse, and behavioral aspects of adherence. ..
  41. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
    ..This INIA makes use of several Genetic Animal Models Core Components, relates well to other INIA UOls, and also will provide input to the Gene Expression, Imaging and the Bioinformatics Cores. ..
  42. Targeting early proteins for therapeutic vaccines
    Jay Rappaport; Fiscal Year: 2005
    ..If successful, this strategy may be beneficial in further controlling HIV infection and may permit patients treated with HAART during chronic infection to realize independence from pharmacotherapeutic regimens. ..
  43. Continuation of the FIND Study
    Barry Freedman; Fiscal Year: 2006
    ..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
  44. Monocyte/macrophage activities and trafficking in HIVE
    Jay Rappaport; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
  46. Anal Dysplasia in HIV+ and HIV- men
    Timothy Wilkin; Fiscal Year: 2006
    ..This study will help provide important new information on which groups of HIV+ men may benefit from screening and how HAART may modify this risk. ..
  47. Transcriptional regulation in chronic renal disease pathogenesis
    LESLIE BRUGGEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  49. COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT
    Scott Hammer; Fiscal Year: 2006
    ..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..