Genomes and Genes
aids associated nephropathy
Summary: Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.
Publications222 found, 100 shown here
- MYH9 is a major-effect risk gene for focal segmental glomerulosclerosisJeffrey B Kopp
Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 40:1175-84. 2008..2, 95% CI = 1.5-3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans...
- Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturationS J Shankland
Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle 98195 6521, USA
Kidney Int 58:674-83. 2000..In the current study, we determined the expression and possible role of specific CDK inhibitors in podocyte proliferation in human disease characterized by podocyte injury...
- Recent progress in HIV-associated nephropathyMichael J Ross
Division of Nephrology, The Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Am Soc Nephrol 13:2997-3004. 2002
- Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expressionL A Bruggeman
Divison of Nephrology, Mount Sinai Medical Center, New York 10029, USA
J Clin Invest 100:84-92. 1997..These studies suggest that in humans, a direct effect of HIV-1 expression is likely the essential cause of HIVAN, rather than an indirect effect of cytokine dysregulation...
- HIV-1 Nef induces proliferation and anchorage-independent growth in podocytesMohammad Husain
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Am Soc Nephrol 13:1806-15. 2002..These data indicate that Nef induces multiple proliferative effects in podocytes in culture and that nef may therefore be an important gene in the pathogenesis of HIVAN in vivo...
- Podocyte cell cycle regulation and proliferation in collapsing glomerulopathiesL Barisoni
Department of Pathology, New York University, New York 10016, USA
Kidney Int 58:137-43. 2000..Exceptions to this rule are collapsing glomerulopathies (CGs), including HIV-associated nephropathy (HIVAN) and idiopathic CG, where podocytes undergo a dysregulation of their differentiated phenotype and proliferate...
- HIV dementia: an evolving diseaseJustin C McArthur
Johns Hopkins University HIV Neurosciences Program, Baltimore, MD, USA
J Neuroimmunol 157:3-10. 2004..relating to HIV-dementia, including: (a) are there differing phenotypes or temporal patterns of progression in HIV-dementia? (b) what determines these temporal patterns? and (c), what has been the impact of therapy on HIV dementia?..
- Resolution of renal failure after initiation of HAART: 3 cases and a discussion of the literatureJeffrey T Kirchner
Comprehensive Care Clinic for HIV, Department of Family and Community Medicine, Lancaster General Hospital, Lancaster, PA, USA
AIDS Read 12:103-5, 110-2. 2002..We report 3 patients believed to have HIVAN who exhibited marked improvement in renal function after treatment with a regimen comprising 2 nucleoside reverse transcriptase inhibitors and a protease inhibitor...
- Human immunodeficiency virus/acquired immunodeficiency syndrome-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival in the pre highly active antiretroviral therapy eraK C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
J Nephrol 14:377-83. 2001..The patient characteristics and course of HlV/AIDS-associated nephropathy (HIVAN) are presented for a national sample of end-stage renal disease (ESRD)...
- End-stage renal disease in patients infected with human immunodeficiency virus: a retrospective review of 38 casesO O Obayomi
Department of Medicine, Howard University College of Medicine, Washington, DC 20060, USA
J Natl Med Assoc 87:762-5. 1995..Risk factors for HIV infection in these patients were intravenous drug abuse, homosexual behavior, bisexual preference, and blood transfusion. None of these factors consistently influenced the survival of HIV-infected patients with ESRD...
- Human immunodeficiency virus infection and renal failureT K Rao
Renal Diseases Division of the State University of New York, Downstate Medical Center, Brooklyn, New York, USA
Infect Dis Clin North Am 15:833-50. 2001....
- The clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysisLynda Anne Szczech
Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Kidney Int 63:2295-301. 2003..This study describes the clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis to define the clinical needs of this growing population...
- Predictors of renal outcome in HIV-associated nephropathyFrank A Post
Academic Dept of HIV GUM, King s College London School of Medicine at Guy s, King s College, London, United Kingdom
Clin Infect Dis 46:1282-9. 2008..This study was performed to study the epidemiology of HIVAN in a predominantly black African population and the impact of highly active antiretroviral therapy and other factors on the development of end-stage renal disease...
- Renal disease in patients with HIV infection: epidemiology, pathogenesis and managementDerek M Fine
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Drugs 68:963-80. 2008..Only with greater awareness of kidney-disease manifestations and their implications in this particularly vulnerable population will we be able to achieve success in confronting this growing problem...
- HIV-1 and HIV-Associated Nephropathy 25 Years LaterChristina M Wyatt
Mount Sinai School of Medicine, Box 1243, One Gustave L Levy Place, New York, NY 10029
Clin J Am Soc Nephrol 2:S20-4. 2007..This article reviews the history of HIV and HIVAN, focusing on advances in the understanding of pathogenesis, epidemiology, and treatment...
- HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and managementMohamed G Atta
Expert Rev Anti Infect Ther 6:365-71. 2008..Furthermore, HAART, corticosteroids and inhibition of the renin-angiotensin axis are potentially helpful in delaying disease progression, as well as the need for renal replacement therapy...
- Unusual presentations of primary human immunodeficiency virus infectionSusan Szabo
HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899 1668, USA
AIDS Patient Care STDS 16:251-4. 2002..Serologic testing demonstrated HIV seroconversion. Clinicians need to have a high index of suspicion when evaluating patients even when risk behaviors are not readily apparent...
- The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infectionLynda Anne Szczech
Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Kidney Int 66:1145-52. 2004..This study was undertaken to compare HIVAN to the spectrum of other kidney diseases seen among HIV-infected patients...
- Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridolPeter J Nelson
Division of Nephrology, Box 1243, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Antimicrob Chemother 51:921-9. 2003..These results demonstrate for the first time that targeting the cyclin-dependent kinases that support HIV-1 expression can ameliorate HIV-induced disease in an animal model...
- [The methods of therapy ESRD patients infected with the human immunodeficiency virus-HIV]Jolanta Gozdowska
Klinika Medycyny Transplantacyjnej i Nefrologii Instytutu Transplantologii AM w Warszawie
Przegl Lek 65:82-6. 2008..In this article authors present the general information about HIV infection (epidemiology, diagnosis and treatment) as well as methods of therapy ESRD like hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation...
- Human immunodeficiency virus-associated nephropathyChun Fu Lai
Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
J Formos Med Assoc 105:680-4. 2006..In summary, this case of HIVAN in a Taiwanese patient shows that the condition may progress to ESRD despite successful viral suppression with HAART...
- Solid organ transplantation in HIV-infected recipientsSuzanne El Sayegh
Division of Nephrology, Mount Sinai School of Medicine, New York 10029, USA
Pediatr Transplant 8:214-21. 2004..In this article We review the literature to date in liver and renal transplantation, including more recent data in patients receiving HAART...
- Kidney biopsy in HIV: beyond HIV-associated nephropathyDerek M Fine
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Kidney Dis 51:504-14. 2008
- The clinical characteristics of HIV-infected patients receiving dialysis in France between 1997 and 2002Cecile Vigneau
Department of Nephrology A, Tenon Hospital, Paris, France
Kidney Int 67:1509-14. 2005..In 1997, 0.38% of dialysis patients in France were infected by human immunodeficiency virus (HIV). No prevalence data were available in France since the widespread introduction of highly active antiretroviral therapy...
- HIV-associated nephropathy: Epidemiology, pathogenesis, and treatmentElizabeth S Herman
Division of Nephrology, Mount Sinai Medical Center, New York, NY, USA
Semin Nephrol 23:200-8. 2003....
- HIV-1 infection and the kidney: an evolving challenge in HIV medicineThushan I de Silva
Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, L Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
Mayo Clin Proc 82:1103-16. 2007..Host factors may modify disease expression at the level of cytokine networks and the renal microvasculature and contribute to the pathogenic effects of HIV-1 infection on the kidney...
- [Problem of HIV-infected patients receiving dialysis]Andrzej Steciwko
Katedra i Zakład Medycyny Rodzinnej, Akademia Medyczna we Wrocławiu
Przegl Lek 61:185-91. 2004..We present also algorithms of management with patient with acute/chronic renal failure in dependence on result of HIV test...
- The impact of HIV on chronic kidney disease outcomesA I Choi
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Kidney Int 72:1380-7. 2007..HIV-infected white patients experienced higher rates of death but a lower risk of ESRD than their counterparts with diabetes. Our results highlight a need to study mortality and mechanisms of ESRD in the HIV infected population...
- Critical role for Nef in HIV-1-induced podocyte dedifferentiationMasaaki Sunamoto
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 64:1695-701. 2003..These data suggest that Nef induces many of the changes we observe in HIV transgenic model and, as a result, this now defines the pathway for exploration of host responses to HIV-1 infection...
- Antiretroviral drugs and the kidney: dosage adjustment and renal toleranceHassane Izzedine
Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
Curr Pharm Des 10:4071-9. 2004..6 to 1%). Therefore, administration of antiretroviral drugs in human immunodeficiency virus (HIV) patients with nephropathy is not uncommon...
- Highly active antiretroviral therapy and the incidence of HIV-1-associated nephropathy: a 12-year cohort studyGregory M Lucas
Johns Hopkins University, Baltimore and the Good Samaritan Hospital, Baltimore, Maryland, USA
AIDS 18:541-6. 2004..to assess temporal changes in the incidence of human immunodeficiency virus-1-associated nephropathy (HIVAN), and the association with use of highly active antiretroviral therapy (HAART)...
- End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004Gregory M Lucas
Department of Medicine, Divisions of Infectious Diseases, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, USA
AIDS 21:2435-43. 2007..HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT)...
- [Henoch-Schönlein purpura nephritis in a patient infected with the human immunodeficiency virus]Hiromi Hidaka
Department of Nephrology, Tokyo Medical University, Tokyo, Japan
Nihon Jinzo Gakkai Shi 45:387-92. 2003..After a year, urinary protein was negative, but mild microhematuria persisted. We speculate that the refractory nephrotic syndrome in this patient might be associated with the abnormal immunological condition due to HIV infection...
- Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathyMichael D Ross
Department of Medicine, Divisions of Nephrology and Infectious Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 278:33248-55. 2003..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN...
- BK virus-associated renal failure among HIV patientsNancy Crum-Cianflone
AIDS 21:1501-2. 2007
- Genetic susceptibility, HIV infection, and the kidneyKrzysztof Kiryluk
Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Clin J Am Soc Nephrol 2:S25-35. 2007....
- Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathwayJohn Cijiang He
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
J Am Soc Nephrol 18:93-102. 2007..These results demonstrate the mechanism by which atRA reverses the proliferation of podocytes that is induced by HIV-1...
- Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathyPeter Dickie
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Virology 322:69-81. 2004..However, the unique contribution of macrophage-specific Vpr expression in the development of glomerular disease was underscored by the induction of FGS in multiple murine lines bearing a c-fms/vpr transgene...
- Kidney transplants in HIV patients?Tracy Coleman
Hahnemann University Hospital, Philadelphia, USA
RN 69:33-8; quiz 39. 2006
- [HIV-1 and renal cells: pathogenesis of HIV-associated nephropathy]P G Conaldi
Laboratorio di Virologia, Dipartimento di Medicina e Sanita Pubblica, Universita dell Insubria, Varese, Italy
G Ital Nefrol 22:569-80. 2005....
- A cross-sectional study of HIV-seropositive patients with varying degrees of proteinuria in South AfricaT M Han
Department of Nephrology, Division of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Kidney Int 69:2243-50. 2006..This will allow diagnosis and treatment of HIVAN at an early stage and may prevent further disease progression...
- Improved survival in HIV-infected African-Americans with ESRDJ MacRae
Department of Medicine, Box 50, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Clin Nephrol 64:124-8. 2005..To determine if there has been improvement in survival of HIV-infected patients with end-stage renal failure subsequent to widespread use of highly active antiretroviral therapy...
- HIV-associated renal diseases and highly active antiretroviral therapy-induced nephropathyJ Roling
Department of Infectious Diseases, Medizinische Poliklinik, Ludwig Maximilians Universitat, University of Munich, Munich, Germany
Clin Infect Dis 42:1488-95. 2006..In this article, we review the current knowledge about acute and chronic HIV-associated renal disease, metabolic alterations and related nephropathies, and toxic drug effects of combination antiretroviral pharmacotherapy...
- Viral load and HIV-associated nephropathyHassane Izzedine
N Engl J Med 353:1072-4. 2005
- HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cellsMichael J Ross
Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Acquir Immune Defic Syndr 42:1-11. 2006..These studies provide novel insights into the mechanisms by which HIV-1 infection of tubular epithelial cells leads to tubulointerstitial inflammation and progressive renal injury...
- Absence of HIV-associated nephropathy in EthiopiansDoron M Behar
Department of Critical Care Medicine, The Bruce Rappaport Faculty of Medicine and Research Institute, Haifa, Israel
Am J Kidney Dis 47:88-94. 2006..Accordingly, we sought to determine whether a similar or different pattern of susceptibility was evident among Ethiopians followed up in an HIV clinic in Israel...
- HIV-2 infection and HIV-associated nephropathyHassane Izzedine
AIDS 20:949-50. 2006
- Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse modelNoriyuki Hiramatsu
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
J Am Soc Nephrol 18:515-27. 2007..AT1R blockade could be beneficial in the treatment of HIVAN by ameliorating podocyte injury by avoiding the vicious cycle of nephron reduction and glomerular hypertension...
- Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reactionN Tanji
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, USA
Histol Histopathol 21:393-401. 2006..IS-PCR is a powerful technique to detect viral DNA in human tissue sections, but requires proper use of negative controls to set optimal fixation, protein digestion, and amplification conditions...
- HIV/AIDS--dominant player in chronic kidney diseaseSaraladevi Naicker
Division of Nephrology, University of the Witwatersrand, Johannesburg Hospital Area 551, 7 York Road, Parktown, Johannesburg 2193, South Africa
Ethn Dis 16:S2-56-60. 2006..Preventive strategies need to be determined; prospective studies including antiretroviral therapy, angiotensin-converting enzyme inhibitors, and other therapeutic agents are required...
- Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal diseaseMichael J Ross
Mount Sinai School of Medicine, Division of Nephrology, Box 1243, One Gustave L Levy Place, New York, NY 10029, USA
J Am Soc Nephrol 17:996-1004. 2006..These results suggest a novel role for FAT10 in epithelial apoptosis, which is an important component of the pathogenesis of many renal diseases...
- NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathyMichael J Ross
Division of Nephrology, Mount Sinai Medical Center, New York, New York, USA
J Am Soc Nephrol 16:2403-11. 2005..These results suggest that NF-kappaB may regulate Fas-mediated apoptosis in HIVAN by controlling the expression of Fas ligand in renal epithelium...
- Asymptomatic HIV patient with cardiomyopathy and nephropathy: case report and literature reviewS C Tayal
Department of Genito-Urinary Medicine, Middlesbrough General Hospital, Ayresome Green Lane, Middlesbrough, Cleveland TS5 5AZ, UK
J Infect 42:288-90. 2001..An understanding of the spectrum of renal and cardiac derangements is essential for clinicians in managing patients with HIV disease...
- Antiretroviral therapy in the treatment of HIV-associated nephropathyMohamed G Atta
Department of Medicine, Division of Nephrology, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA
Nephrol Dial Transplant 21:2809-13. 2006..This study was undertaken to further elucidate the potential benefit of ART in HIV-infected patients with documented HIVAN...
- Treatment of HIV-associated nephropathyR Sothinathan
Division of Nephrology, Johns Hopkins University, Baltimore, Maryland 21205, USA
AIDS Patient Care STDS 15:363-71. 2001..Appropriate randomized controlled trials are urgently required in order to further examine the efficacy, optimal timing, and potential side effects of these treatments...
- Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal diseaseElissa J Schwartz
Division of Nephrology, Mount Sinai Medical Center, New York, NY 10029, USA
J Am Soc Nephrol 16:2412-20. 2005..It is concluded that prevention of progression to ESRD should focus on early antiretroviral treatment of HIV-infected patients who have evidence of HIV-associated nephropathy...
- [Acute tubulointerstitial nephritis in HIV infection]M Moddel
Nephrologische Abteilung der Medizinischen Klinik, Stadtspital Waid Zürich
Praxis (Bern 1994) 95:949-51. 2006..After discontinuing medication with atazanavir serum creatinine level decreased spontaneously without steroids. The different etiologies of acute renal failure in patients with human immunodeficiency infection are discussed...
- HIV-associated renal diseases in Africa a desperate need for additional studyScott D Cohen
Nephrol Dial Transplant 22:2116-9. 2007
- Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection?Alexandros B Tsoupras
University of Athens, Faculty of Chemistry, Athens, Greece
AIDS Res Hum Retroviruses 24:1079-86. 2008..These promising results need to be further studied and confirmed by additional in vivo tests in order to optimize HAART efficacy...
- The urological management of the patient with acquired immunodeficiency syndromeChris F Heyns
Department of Urology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
BJU Int 95:709-16. 2005..After occupational exposure to HIV, chemoprophylaxis with antiretroviral medication can significantly reduce the probability of HIV transmission...
- Chronic kidney disease in human immunodeficiency virus infectionJ Fabian
Division of Nephrology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Panminerva Med 49:51-66. 2007..An integrated plan to reduce the progression to kidney failure together with lifestyle measures, focusing also on high risk groups with effective management at all levels of chronic kidney disease remains essential...
- Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15George W Nelson
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
Hum Mol Genet 19:1805-15. 2010..Rs5750250 combined with rs11912763 had receiver operator characteristic (ROC) C statistics of 0.80, 0.73 and 0.65 for HIVAN, FSGS and H-ESKD, respectively, allowing prediction of genetic risk by typing two SNPs...
- Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathyMohamed G Atta
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Med 118:1288. 2005....
- Renal cytomembranous inclusions in idiopathic renal disease as predictive markers for the acquired immunodeficiency syndromeP Chander
Department of Pathology, New York Medical College, Valhalla 10595
Hum Pathol 19:1060-4. 1988..These structures may be of predictive value for the future development of AIDS in patients presenting with apparent idiopathic renal disease...
- Course and prognosis of human immunodeficiency virus-associated nephropathyL Carbone
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
Am J Med 87:389-95. 1989..Patient survival is dependent upon the stage of HIV infection. These findings may prove useful in devising more effective strategies for the care of this growing patient population...
- Transforming growth factor beta increases the expression of HIV-1 gene in transfected human mesangial cellsR R Shukla
Department of Molecular Biology, George Washington University Medical Center, Washington, D C
Kidney Int 44:1022-9. 1993..We further studied whether up-regulation of HIV-1 LTR expression in HMC was mediated by the effect of TGF-beta on the interaction of transcription factors to their binding sites.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Renal effects of angiotensin-converting enzyme inhibitors that result in cost savings and improved patient outcomesA L Swislocki
Medical Service 111, Department of Veterans Affairs NCHCS, 150 Muir Road, Martinez, CA 94553, USA
Am J Manag Care 7:283-95. 2001..Many questions remain about the categories of patients that benefit from ACE inhibitor use...
- Cyclin-dependent kinases as cellular targets for antiviral drugsLuis M Schang
Department of Biochemistry, Signal Transduction Research Group, University of Alberta, 315C Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
J Antimicrob Chemother 50:779-92. 2002....
- Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 geneShay Tzur
Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
Hum Genet 128:345-50. 2010....
- Renal manifestations in HIV-infected Jamaican childrenJ Steel-Duncan
Department of Obstetrics, Gynaecology and Paediatrics, The University of the West Indies, Kingston 7, Jamaica
West Indian Med J 57:246-52. 2008..With increased public access to antiretroviral therapy since 2002 and subsequent survival, renal complications are increasingly recognized among the surviving cohort of infected children...
- Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patientDerek M Fine
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Semin Nephrol 28:545-55. 2008..As a consequence of establishing an accurate diagnosis, improved patient outcome can best be accomplished through disease-specific intervention...
- HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting proteinTing Chi Lu
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Biol Chem 283:8173-82. 2008..We conclude that in HIV-infected podocytes, Nef, through the recruitment of DIP and p190RhoAGAP to Nef-Src complex, activates p190RhoAGAP and down-regulates RhoA activity...
- Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferationA A Kapasi
Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
Am J Physiol Renal Physiol 280:F333-42. 2001..These results suggest that HIV-1 gp 120 induces alterations in conflicting survival signaling pathways that contribute to the potential dual effects of gp 120 in promoting or inhibiting HMC proliferation...
- Nef modulation of HIV type 1 gene expression and cytopathicity in tissues of HIV transgenic miceP Dickie
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
AIDS Res Hum Retroviruses 16:777-90. 2000..This HIV proviral transgenic model has demonstrated the capacity of HIV-1 Nef to contribute to HIV cytopathicity by altering cellular maturation and viral gene expression in vivo...
- Correlation of CD4 counts with renal disease in HIV positive patientsHari Janakiraman
Department of Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, India
Saudi J Kidney Dis Transpl 19:603-7. 2008..We conclude that our study demonstrates that both proteinuria and HIVAN are common in HIV infected patients. Proteinuria has a negative correlation with the CD4 counts and hemoglobin levels...
- Renal involvement in patients infected with HIV: experience at San Francisco General HospitalS A Mazbar
Division of Nephrology, San Francisco General Hospital, California
Kidney Int 37:1325-32. 1990..We also reviewed 91 consecutive autopsies performed in patients dying with AIDS at SFGH between 1981 and 1986.(ABSTRACT TRUNCATED AT 250 WORDS)..
- HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical propertiesR Tandon
Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Physiol Renal Physiol 292:F701-10. 2007..The mechanical properties of the WT podocytes suggest that these cells can better maintain capillary integrity than the HIVAN podocytes and implicate pathological assembly of the cytoskeleton as a mechanism of HIVAN...
- Impact of highly active antiretroviral therapy on organ-specific manifestations of HIV-1 infectionD Torre
Department of Infectious Diseases, General Hospital and Macchi Foundation, Varese, Italy
HIV Med 6:66-78. 2005....
- HIV associated nephropathy: a treatable conditionM G Brook
Patrick Clements Clinic, Department of GUM HIV, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK
Sex Transm Infect 77:97-100. 2001..To describe current knowledge on the aetiology, pathology, diagnosis, and treatment of HIV associated nephropathy...
- Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathyDaniele Marras
Division of Nephrology, Department of Medicien, Mount Sinai School of Medicine, New York, New York, USA
Nat Med 8:522-6. 2002..These data, along with the detection of HIV-1-specific proviral DNA and mRNA in tubular epithelium cells, argue strongly for localized replication of HIV-1 in the kidney and the existence of a renal viral reservoir...
- Outcome of patients with human immunodeficiency virus on maintenance hemodialysisC Ortiz
Department of Medicine, University of Miami School of Medicine, Florida
Kidney Int 34:248-53. 1988..In asymptomatic HIV carriers and in patients with ARC, however, maintenance hemodialysis provides meaningful, long-term life support...
- Association of parvovirus B19 infection with idiopathic collapsing glomerulopathyA Moudgil
Department of Pediatrics, Division of Transplant Immunology, Steven Spielberg Pediatric Research Center, UCLA School of Medicine, Los Angeles, California, USA
Kidney Int 59:2126-33. 2001..We previously reported a renal transplant recipient with de novo CG and red cell aplasia in association with persistent parvovirus B19 (PVB19) infection. This prompted us to look for an association between PVB19 infection and CG...
- Glomerular lesions in HIV-positive patients: a 20-year biopsy experience from Northern ItalyM Nebuloni
L Sacco Department Clinical Sciences, L Sacco Hospital, University of Milan, Milan, Italy
Clin Nephrol 72:38-45. 2009..Moreover, in the group of non-HIVAN patients, the possible differences in histological characteristics from non-HIV lesions were investigated...
- CKD in HIV-infected patients other than HIV-associated nephropathyAjay K Rachakonda
Division of Kidney Urologic and Hematologic Diseases, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892, USA
Adv Chronic Kidney Dis 17:83-93. 2010..The results of treating kidney disease in HIV-infected patients remain unclear, and properly designed randomized controlled trials of the treatment of ICGN with HAART and other approaches are desperately needed...
- HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVANMohammad Husain
Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
AIDS 19:1975-80. 2005..To determine the specific role of Nef in the pathogenesis of HIV-associated nephropathy...
- Renal pathology and HIV infection in ThailandK Praditpornsilpa
Department of Medicine, Police General Hospital, Bangkok, Thailand
Am J Kidney Dis 33:282-6. 1999..Although the data in this study are limited to 26 HIV-infected Thai patients, we believe that HIVAN is uncommon in the Asian HIV-infected population...
- HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulationP G Conaldi
Division of Microbiology, Department of Clinical and Biological Sciences, University of Insubria, Varese 21100, Italy
J Clin Invest 102:2041-9. 1998..These findings may explain the prominent histopathology of HIV-associated nephropathy and demonstrate that the apoptosis of nonlymphoid cells can be directly induced by HIV-1...
- An uncommon glomerular disease in an HIV patient: value of renal biopsy and review of the literatureC Chen
Department of Medicine, Tufts Medical Center, Boston, MA, USA
Clin Nephrol 75:80-8. 2011..We report another case of ITG in an HCV- and HBV-negative, AA female...
- Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytesP J Nelson
Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Am Soc Nephrol 12:2827-31. 2001..Thus, suppression of HIV-1 transcription by selective cyclin-dependent kinase-9 inhibitors may be a useful therapeutic strategy for the treatment of HIVAN...
- APOBEC3G expression is restricted to epithelial cells of the proximal convoluted tubules and is not expressed in the glomeruli of macaquesM Sarah Hill
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Histochem Cytochem 55:63-70. 2007....
- Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathwaysJohn Cijiang He
Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
J Clin Invest 114:643-51. 2004..These data suggest that Nef-induced activation of Stat3 and Ras-MAPK1,2 via Src-dependent pathways is responsible for podocyte proliferation and dedifferentiation, a characteristic finding in collapsing FSGS of HIVAN...
- Lupus-like nephritis in an HIV-positive patient: report of a case and review of the literatureD Tabechian
Division of Allergy lmmunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Clin Nephrol 60:187-94. 2003..Considering previously reported cases, it appears that lupus-like nephritis is a rare but well-defined pattern of immune-complex-induced renal injury seen in HIV-infected patients. It appears to be markedly responsive to HAART...
- Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infectionChristina M Wyatt
Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Expert Opin Drug Saf 5:275-87. 2006....
- Activation of Notch signaling pathway in HIV-associated nephropathyMadhulika Sharma
Department of Anatomy and Cell Biology and The Kidney Institute, University of Kansas Medical Center, Kansas City, USA
AIDS 24:2161-70. 2010..To determine whether Notch signaling is involved in renal disorder associated with HIVAN, we evaluated the expression of Notch receptors in HIVAN...
- [Secondary glomerular nephropathies]Philippe Lesavre
Service de néphrologie et INSERM U507, Hopital Necker, 75743 Paris Cedex 15
Rev Prat 53:2039-48. 2003....
- Immunotactoid glomerulopathy in an HIV-positive African-American manJeffrey L Martin
Hypertension and Kidney Specialists of Lancaster, Lancaster, PA 17543, USA
Am J Kidney Dis 42:E6-10. 2003..This case emphasizes the diverse glomerular lesions seen in HIV-positive patients and supports the use of renal biopsy to establish a diagnosis...
- Clinical and basic science advances in the treatment of HIV-1 and its associated kidney diseaseA Sethi
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Minerva Urol Nefrol 61:439-54. 2009..Emphasis is placed on early diagnosis and timely treatment of kidney disease and heightened awareness particularly among the vulnerable population that bears most of the disease burden...
- Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteriesGuillaume Canaud
Universite Paris Descartes, Paris, France
Am J Kidney Dis 55:558-65. 2010..Together, these data suggest that acute glomerular ischemia may lead to glomerular collapse in kidney transplants...
- Controversies in the pathogenesis of HIV-associated renal diseasesLeslie A Bruggeman
Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
Nat Rev Nephrol 5:574-81. 2009..Rodent HIV-1 models, for instance, cannot replicate all features of immune activation, a process that could have an important role in the pathogenesis of the HIV-associated renal diseases...
- [Post-infectious glomerulonephritis]G Barbiano di Belgiojoso
U O Nefrologia e Dialisi, Azienda Ospedaliera Polo Universitario Luigi Sacco, Milano, Italy
G Ital Nefrol 20:184-99. 2003..Among the rare viral infections, we ultimately, mention the association between Parvovirus B19 and "collapsing" focal segmental glomerulosclerosis...
- Prevalence and clinical characteristics of HIV type 1-infected patients receiving dialysis in Spain: results of a Spanish survey in 2006: GESIDA 48/05 studyJ C Trullas
Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 24:1229-35. 2008..05). The prevalence of HIV infection in Spanish dialysis units in 2006 was 0.54% HCV coinfection was very frequent (61%) and the percentage of patients included on the Spanish RT waiting list was low (12%)...
- Role of KLF15 in podocyte differentiationSandeep Mallipattu; Fiscal Year: 2012..abstract_text> ..
- Role of HIPK2 in Kidney Tubulointerstitial InjuryAVI MA'AYAN; Fiscal Year: 2013....
- APOL1 variants: Understanding the basis of disparities in rates of kidney diseaseMartin R Pollak; Fiscal Year: 2013..We ask whether these molecules alter APOL1 biology in vitro, and whether biochemical levels of these mediators predict which individuals with the APOL1 risk genotype are likely to develop kidney disease. ..
- Natural History of MYH9-Associated NephropathyBARRY IRA FREEDMAN; Fiscal Year: 2012..This will benefit individuals at risk who could benefit from therapeutic intervention to alleviate disease at an earlier stage. The anticipated benefits to the population at large outweigh the minimal risk involved in the study. ..
- Role of Protein Acetylation in Diabetic kidney DiseaseJohn C He; Fiscal Year: 2013..The proposed studies will help us to understand how acetylation of TFs affects their target gene expression in diabetic kidneys and determine whether BrDi could be developed as a new class of drugs to treat patients with DKD. ..
- Cell junction proteins in podocyte injury repairJeffrey Simske; Fiscal Year: 2013..These studies will have important implications toward the development of novel therapies directed at glomerular diseases characterized by foot processes effacement where preventing or repairing damaged podocytes would be beneficial. ..
- Epigenetic factors and HIV-associated NephropathyPravin C Singhal; Fiscal Year: 2013....
- Molecular Mechanism of APOL1 Associated Kidney DiseaseMartin R Pollak; Fiscal Year: 2013..We will also define the specific interactions between the wild-type, G1, and G2 forms of ApoL1 in vivo. Lastly, we will examine the role of ApoL1 variants in promoting or preventing apoptosis of glomerular cells. ..
- p66ShcA in HIV associated NephropathyPravin C Singhal; Fiscal Year: 2013..At present, there is no specific treatment to cure this disease. Our long term research goal is to develop strategies to slow down the progression and/or cure of this devastating kidney disease. ..
- Basic FGF Low Affinity Receptors in HIVANPatricio E Ray; Fiscal Year: 2012....
- Renin Angioensin Aldosterone System in Drub Abuse and HIV-associated NephropathyPravin C Singhal; Fiscal Year: 2013..Based on our preliminary data, we hypothesize that modulation of RAAS by its selective inhibitors will not only prevent or attenuate HIV-1- induced renal injury but also delay or slow down the progression of HIVAN. ..
- RNA profiling of HIV-associated nephropathy in patients with the MYH9 risk allelePAUL EVAN KLOTMAN; Fiscal Year: 2010..Findings from the proposed research are likely to provide insights into the increased susceptibility to kidney disease and end-stage renal disease among people of African descent. ..
- Kidney disease mechanisms associated with human genetic variationJohn R Sedor; Fiscal Year: 2012....
- Program Project: The Pathogenesis of HIV-Associated NephropathyPAUL EVAN KLOTMAN; Fiscal Year: 2013..Results from these studies will provide improved understanding of HIVAN pathogenesis, AIDS pathogenesis, appropriate strategies for therapy, and insights into renal disease susceptibility of Blacks in general. ..
- MULTIPHOTON LASER SCANNING MICROSCOPEVICTOR LOUIS FRIEDRICH; Fiscal Year: 2010....
- HIV ASSOCIATED NEPHROPATHY IN CHILDRENJOSE STRAUSS; Fiscal Year: 1993..An effort will also be made to identify certain clinical indicators which can predict the development of, or correlate with the severity of, the renal disease...
- Improving Annenberg 23 in Support of Translational ResearchDennis S Charney; Fiscal Year: 2010....
- 6th International Podocyte ConferenceStuart Shankland; Fiscal Year: 2006..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
- HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTSPravin Singhal; Fiscal Year: 2007..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
- EPIDEMIOLOGY AND CLINICAL COURSE OF HIV NEPHROPATHYLynda Anne Szczech; Fiscal Year: 2004....
- Sidekick proteins in HIV-associated nephropathyLewis Kaufman; Fiscal Year: 2009..These studies should elucidate the mechanisms by which sdk-1 contributes to podocyte dysfunction in HIVAN. ..
- Transgene Induced HIV-Associated NephropathyVincent Gattone; Fiscal Year: 2004..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
- VEGF in podocyte injury induced by HIVSonal Shah; Fiscal Year: 2006..Also, we hope to investigate whether VEGF inhibitors can improve the kidney disease in HIV-1 (TG26) transgenic mice as this could open up a new avenue in the treatment of HIV. [unreadable] [unreadable] [unreadable]..
- Iron and Vitamin E in Childhood HIV-Associated Renal DiseasePatricio Ray; Fiscal Year: 2006..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. [unreadable] [unreadable]..
- Novel Animal Model System of AIDS-Kaposi SarcomaPatricio Ray; Fiscal Year: 2005....
- Epithelial gene expression in HIV-associated nephropathyMichael Ross; Fiscal Year: 2006..It is also possible that genes implicated in the pathogenesis of HIVAN maybe important factors contributing to the marked predisposition of African-Americans to nearly all causes of renal failure. ..
- FAT10 a candidate gene for epithelial apoptosis in HIV-associated nephropathyMichael Ross; Fiscal Year: 2007..These studies will advance our understanding of HIVAN pathogenesis and may yield a novel therapeutic target for the treatment of HIVAN and other renal diseases. [unreadable] [unreadable]..
- The Prevalence, Pathogenesis And Therapy of HIVANJonathan Winston; Fiscal Year: 2006..The award is structured to allow me to intensify my efforts in clinical research, develop new research skills through postgraduate work, and mentor trainees in clinical epidemiology, clinical trials and outcomes research. ..
- PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITISCHARLES ALPERS; Fiscal Year: 2008..Specific Aim 4 will examine the effects of these interventions on systemic cryoglobulinemia. It is anticipated that the findings will lead to better treatments for cryoglobulinemia and associated MPGN. ..
- Biotechnology Center for Comparative GenomicsCHARLES ALPERS; Fiscal Year: 2003..abstract_text> ..
- PATHOGENESIS OF HIV ASSOC THROMBOTIC MICROANGIOPATHYCHARLES ALPERS; Fiscal Year: 2003..abstract_text> ..
- Effect of Alcohol on SHIV NeuroinvasionEdward Stephens; Fiscal Year: 2004..The results of these studies should provide direct evidence on the effect of ethanol on primate lentivirus neuroinvasion and neuropathogenesis. ..
- Pathogenesis of HIVAN: the role of NefJOHN HE; Fiscal Year: 2007..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
- SHIV ASSOCIATED ENCEPHALOPATHYEdward Stephens; Fiscal Year: 2003..It is anticipated that the proposed studies will provide valuable information which will improve our understanding of HIV-1 neuropathogenesis. ..
- PDGF-D INDUCED MODELS OF MESANGIAL GLOMERULOPATHYCHARLES ALPERS; Fiscal Year: 2005..abstract_text> ..
- RAGE and GlomerulosclerosisVIVETTE D AGATI; Fiscal Year: 2007..We propose that identification of RAGE-dependent mechanisms in glomerular diseases may lead to novel therapies to prevent, stabilize or reverse the course of chronic GS. ..
- Directly observed antiretroviral therapy in drug abusersGREGORY LUCAS; Fiscal Year: 2006..My career plan and research proposal are consistent with my long-term goals of becoming an effective independent investigator, and optimizing treatment outcomes in HIV-infected IDUs. ..
- A New DNA Vaccine Against HIV Disease in MacaquesEdward Stephens; Fiscal Year: 2008..Vaccine boosts will continue after drug therapy had been withdrawn. These studies will be applicable to HIV infected persons under HAART. ..
- Role of Targeted Mutations in ViF on SHIV PathogenesisEdward Stephens; Fiscal Year: 2006..The proposed studies will provide new information on the role of this Vif motif in pathogenesis using a relevant macaque model. ..
- Directly Administered HIV Therapy in Methadone ClinicsGREGORY LUCAS; Fiscal Year: 2009..Our research team has an established history of collaboration in this area, and brings together a wealth of research expertise in HIV treatment outcomes, substance abuse, and behavioral aspects of adherence. ..
- Role of Amygdala in Ethanol Reinforcement and AnxietyAmanda Roberts; Fiscal Year: 2005..This INIA makes use of several Genetic Animal Models Core Components, relates well to other INIA UOls, and also will provide input to the Gene Expression, Imaging and the Bioinformatics Cores. ..
- Targeting early proteins for therapeutic vaccinesJay Rappaport; Fiscal Year: 2005..If successful, this strategy may be beneficial in further controlling HIV infection and may permit patients treated with HAART during chronic infection to realize independence from pharmacotherapeutic regimens. ..
- Continuation of the FIND StudyBarry Freedman; Fiscal Year: 2006..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
- Monocyte/macrophage activities and trafficking in HIVEJay Rappaport; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIAJoseph Eustace; Fiscal Year: 2004..Eustace to build on his current theoretical knowledge, make the transition into an independent clinical scientist and prepare him for a career investigating the role of nutrition in renal disease. ..
- Anal Dysplasia in HIV+ and HIV- menTimothy Wilkin; Fiscal Year: 2006..This study will help provide important new information on which groups of HIV+ men may benefit from screening and how HAART may modify this risk. ..
- Transcriptional regulation in chronic renal disease pathogenesisLESLIE BRUGGEMAN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRDBarry Freedman; Fiscal Year: 2001..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
- COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNITScott Hammer; Fiscal Year: 2006..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..