latex hypersensitivity

Summary

Summary: Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.

Top Publications

  1. ncbi Recent developments in latex allergy
    Kristiina Turjanmaa
    Department of Dermatology, University of Tampere and University Hospital of Tampere, Helsinki, Finland
    Curr Opin Allergy Clin Immunol 2:407-12. 2002
  2. ncbi Component-resolved diagnosis from latex allergy by microarray
    D G Ebo
    Department of Immunology Allergology Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Clin Exp Allergy 40:348-58. 2010
  3. ncbi In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex
    David I Bernstein
    University of Cincinnati College of Medicine, Ohio, USA
    J Allergy Clin Immunol 111:610-6. 2003
  4. ncbi Latex hypersensitivity: a closer look at considerations for dentistry
    Tara Kean
    Department of Dental Clinical Sciences, Faculty of Dentistry, Dalhousie University, Halifax NS B3H 3J5
    J Can Dent Assoc 75:279-82. 2009
  5. pmc Latex allergy: a follow up study of 1040 healthcare workers
    F Larese Filon
    UCO Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Universita degli Studi di Trieste, Trieste, Italy
    Occup Environ Med 63:121-5. 2006
  6. ncbi Changes in rates of natural rubber latex sensitivity among dental school students and staff members after changes in latex gloves
    M Joan Saary
    Gage Occupational and Environmental Health Unit, University of Toronto, St Michael s and Toronto Western Hospitals
    J Allergy Clin Immunol 109:131-5. 2002
  7. ncbi Evaluation of patatin as a major cross-reactive allergen in latex-induced potato allergy
    Mirko H H Schmidt
    Research Institute for Occupational Medicine of the Berufsgenossenschaften, Ruhr University, Department of Allergology Immunology, Bochum, Germany
    Ann Allergy Asthma Immunol 89:613-8. 2002
  8. ncbi Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein
    Donald H Beezhold
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann Allergy Asthma Immunol 90:439-45. 2003
  9. ncbi Tolerance and effects on skin reactivity to latex of sublingual rush immunotherapy with a latex extract
    A Cistero Bahima
    Institut Universitari Dexeus, Barcelona, Spain
    J Investig Allergol Clin Immunol 14:17-25. 2004
  10. ncbi Latex allergy: a model for therapy
    J M Rolland
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Clin Exp Allergy 38:898-912. 2008

Research Grants

Detail Information

Publications178 found, 100 shown here

  1. ncbi Recent developments in latex allergy
    Kristiina Turjanmaa
    Department of Dermatology, University of Tampere and University Hospital of Tampere, Helsinki, Finland
    Curr Opin Allergy Clin Immunol 2:407-12. 2002
    ..We also discuss methods aimed at quantification of clinically relevant natural rubber latex allergens and studies on B-cell epitopes of major natural rubber latex allergens...
  2. ncbi Component-resolved diagnosis from latex allergy by microarray
    D G Ebo
    Department of Immunology Allergology Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Clin Exp Allergy 40:348-58. 2010
    ..A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy...
  3. ncbi In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex
    David I Bernstein
    University of Cincinnati College of Medicine, Ohio, USA
    J Allergy Clin Immunol 111:610-6. 2003
    ..However, the in vivo importance of native Hev b allergens has not been defined in health care workers (HCWs) with natural rubber latex (NRL) allergy...
  4. ncbi Latex hypersensitivity: a closer look at considerations for dentistry
    Tara Kean
    Department of Dental Clinical Sciences, Faculty of Dentistry, Dalhousie University, Halifax NS B3H 3J5
    J Can Dent Assoc 75:279-82. 2009
    Over the past several decades, latex hypersensitivity has become an increasingly common phenomenon in the dental setting...
  5. pmc Latex allergy: a follow up study of 1040 healthcare workers
    F Larese Filon
    UCO Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Universita degli Studi di Trieste, Trieste, Italy
    Occup Environ Med 63:121-5. 2006
    ....
  6. ncbi Changes in rates of natural rubber latex sensitivity among dental school students and staff members after changes in latex gloves
    M Joan Saary
    Gage Occupational and Environmental Health Unit, University of Toronto, St Michael s and Toronto Western Hospitals
    J Allergy Clin Immunol 109:131-5. 2002
    ..A high rate of sensitization and clinical allergy to natural rubber latex (NRL) gloves has been reported in dental students and staff members...
  7. ncbi Evaluation of patatin as a major cross-reactive allergen in latex-induced potato allergy
    Mirko H H Schmidt
    Research Institute for Occupational Medicine of the Berufsgenossenschaften, Ruhr University, Department of Allergology Immunology, Bochum, Germany
    Ann Allergy Asthma Immunol 89:613-8. 2002
    ..This study was designed to investigate the molecular basis of acquired food sensitization focusing on the storage protein patatin and the patatin-like latex protein Hev b 7...
  8. ncbi Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein
    Donald H Beezhold
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann Allergy Asthma Immunol 90:439-45. 2003
    ..We sought to determine whether Hevea brasiliensis produces LTP and whether it would bind immunoglobulin E from latex-allergic patients...
  9. ncbi Tolerance and effects on skin reactivity to latex of sublingual rush immunotherapy with a latex extract
    A Cistero Bahima
    Institut Universitari Dexeus, Barcelona, Spain
    J Investig Allergol Clin Immunol 14:17-25. 2004
    ..Specific immunotherapy could be a therapeutic tool for the increasing problem of sensitisation to Natural Rubber Latex (NRL)...
  10. ncbi Latex allergy: a model for therapy
    J M Rolland
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Clin Exp Allergy 38:898-912. 2008
    ..The co-administration of adjunct therapies such as anti-IgE or corticosteroids and of appropriate adjuvants for induction of regulatory T cell response offers promise for clinically effective, safe latex-specific vaccines...
  11. ncbi Allergen concentration in natural rubber latex
    H Y Yeang
    Biotechnology and Strategic Research Unit, Rubber Research Institute of Malaysia, Malaysian Rubber Board, Malaysia
    Clin Exp Allergy 36:1078-86. 2006
    ..Hevea brasiliensis latex serum is commonly used as the in vivo and in vitro reference antigen for latex allergy diagnosis as it contains the full complement of latex allergens...
  12. ncbi Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11, a class I chitinase
    G O'Riordain
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Clin Exp Allergy 32:455-62. 2002
    ..Class I chitinases have been identified from chestnut, avocado and banana as relevant allergens. The chitin binding (hevein) domain from these class I chitinases has been postulated to bear the important IgE binding epitopes...
  13. ncbi Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies
    Martha Pedraza-Escalona
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Cd Universitaria, Coyoacan, Mexico, D F 04510, Mexico
    Mol Immunol 46:668-76. 2009
    ..02-IgE interactions. Antibodies recognizing this important allergen have potential to be used to diagnose and ultimately treat latex allergy...
  14. ncbi Natural rubber latex allergy among health care workers: a systematic review of the evidence
    Jean Bousquet
    Service des Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, University Hospital, 34295 Montpellier Cedex 5, France
    J Allergy Clin Immunol 118:447-54. 2006
    ..Natural rubber latex is a recognized allergen, but a recent meta-analysis failed to find any association between latex exposure and allergy in health care workers (HCWs)...
  15. ncbi Sublingual desensitization: a new approach to latex allergy problem
    Giampiero Patriarca
    Department of Internal Medicine, Università Cattolica del Sacro Cuore Policlinico A Gemelli Rome, Italy
    Anesth Analg 95:956-60, table of contents. 2002
    ..All the desensitized patients can now wear latex gloves and undergo medical procedures without any symptoms...
  16. ncbi Natural rubber latex allergy: the impact on lifestyle and quality of life
    V J Lewis
    Welsh Institute of Dermatology, University Hospital of Wales, Health Park, Cardiff CF14 4XN, UK
    Contact Dermatitis 51:317-8. 2004
  17. ncbi The latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, Austria
    Biochem Soc Trans 30:935-40. 2002
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  18. ncbi Exercise with latex sport bands represents a risk for latex allergic patients
    Eva Untersmayr
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Immunol Lett 115:98-104. 2008
    ..Even though latex is labeled on products, it is important that patients as well as athletic trainers and physical therapists recognize the risk of adverse reactions with these bands...
  19. ncbi Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana
    J H Mikkola
    National Public Health Institute, Institute of Occupational Health, Helsinki, Finland
    J Allergy Clin Immunol 102:1005-12. 1998
    ..Patients allergic to natural rubber latex (NRL) frequently exhibit immediate hypersensitivity reactions to banana, but the molecular basis of these putative cross-reactions is unknown...
  20. pmc Outcome of occupational latex allergy--work ability and quality of life
    Albert Nienhaus
    Institution for Statutory Accident Insurance in the Health and Welfare Services, Hamburg, Germany
    PLoS ONE 3:e3459. 2008
    ..The quality of life (QOL) and work ability of health care workers allergic to natural rubber latex (NRL) were assessed after implementation of regulations on powder-free NRL gloves in Germany...
  21. ncbi Latex sublingual immunotherapy: can its safety be predicted?
    Suna Buyukozturk
    Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Allergy, Istanbul University, Istanbul, Turkey
    Ann Allergy Asthma Immunol 104:339-42. 2010
    ..Complete avoidance sometimes cannot be possible in latex-allergic health care workers. So far, very few double-blind placebo-controlled studies revealed the efficacy of sublingual latex immunotherapy (SLIT) in those patients...
  22. ncbi Specific immunotherapy with a standardized latex extract in allergic workers: a double-blind, placebo-controlled study
    Joaquin Sastre
    Servicio de Alergia, Fundacion Jimenez Diaz, Madrid, Spain
    J Allergy Clin Immunol 111:985-94. 2003
    ..Preventive measures have been proposed to reduce the risk of sensitization to natural rubber latex (NRL), but this is not always feasible...
  23. pmc Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats
    Yatin M Shivkar
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Mediators Inflamm 12:299-302. 2003
    ..In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in latex-induced inflammation...
  24. ncbi Effectiveness of a nationwide interdisciplinary preventive programme for latex allergy
    Ute Latza
    Occupational Epidemiology, Institute for Occupational Medicine, Hamburg State Department of Environment and Health, University of Hamburg, Seewartenstrasse 10, 20459 Hamburg, Germany
    Int Arch Occup Environ Health 78:394-402. 2005
    ....
  25. ncbi Primary prevention of natural rubber latex allergy in the German health care system through education and intervention
    Henning Allmers
    Department of Dermatology, Environmental Medicine and Health Sciences, University of Osnabruck, Sedanstrasse 115, 49090 Osnabrück, Germany
    J Allergy Clin Immunol 110:318-23. 2002
    ..There are few published studies to suggest that intervention programs to reduce exposure will lead to primary prevention of sensitization...
  26. ncbi Clinical and occupational outcomes in health care workers with natural rubber latex allergy
    David I Bernstein
    University of Cincinnati College of Medicine, Division of Immunology, Department of Internal Medicine, Cincinnati, Ohio 45267 0563, USA
    Ann Allergy Asthma Immunol 90:209-13. 2003
    ..There is limited information pertaining to clinical outcomes and economic consequences of natural rubber latex (NRL) allergy in health care workers (HCWs)...
  27. ncbi Decreasing incidence of occupational contact urticaria caused by natural rubber latex allergy in German health care workers
    Henning Allmers
    Department of Dermatology, Environmental Medicine and Health Sciences, University of Osnabrueck, Germany
    J Allergy Clin Immunol 114:347-51. 2004
    ..The development of allergy to natural rubber latex (NRL) is a risk for health care workers. A regulation banning powdered NRL gloves was implemented in Germany in 1998...
  28. ncbi Hev b 8, the Hevea brasiliensis latex profilin, is a cross-reactive allergen of latex, plant foods and pollen
    E Ganglberger
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 125:216-27. 2001
    ..Additionally, pollinosis and food-allergic patients with profilin-specific IgE can be at risk of developing latex allergy...
  29. ncbi Latex hypersensitivity: relationship with positive prick test and patch test responses among hairdressers
    E Nettis
    Department of Clinical Immunology and Allergology, University of Bari, Piazza Giulio, Italy
    Allergy 58:57-61. 2003
    ..Natural rubber latex is a frequent cause of IgE-mediated allergy in hairdressers; but a non-IgE-mediated allergy to latex proteins can also occur. Sixty-one hairdressers, reporting latex glove-related symptoms, were enrolled in the study...
  30. ncbi 1,3-beta-glucanases as candidates in latex-pollen-vegetable food cross-reactivity
    O Palomares
    Departamento de Bioquimica y Biologia Molecular, Facultad de Quimica, Universidad Complutense, 28040 Madrid, Spain
    Clin Exp Allergy 35:345-51. 2005
    ..1,3-beta-glucanases (group 2 of pathogenesis-related proteins) are enzymes widely distributed among higher plants and have been recently proven to be significant allergens...
  31. ncbi Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome
    Piia Karisola
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    J Allergy Clin Immunol 115:598-605. 2005
    ..IgE of these patients has been shown to bind endochitinases containing an N-terminal hevein-like domain (HLD). However, evidence on 31-kd endochitinase-induced reactions in vivo is lacking...
  32. ncbi Insights into a conformational epitope of Hev b 6.02 (hevein)
    César A Reyes-López
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Cd Universitaria, 04510, Coyoacán México, DF, Mexico
    Biochem Biophys Res Commun 314:123-30. 2004
    ..Overall our results indicate that the central part of the protein, which comprises three aromatic and other acidic and polar residues, constitutes a conformational epitope...
  33. ncbi Quality of life in patients with latex allergy
    Sultan Al-Otaibi
    Saudi Aramco, Dhahran Health Center, Dhahran, Saudi Arabia
    Occup Med (Lond) 55:88-92. 2005
    ..Exposure to natural rubber latex (NRL) may lead to a variety of allergic clinical manifestations that may affect the quality of life (QOL)...
  34. ncbi Latex-fruit syndrome
    Carlos Blanco
    Servicio de Alergia, Hospital Universitario Dr Negrin, c Barrenco de la Ballena s n, 35012 Las Palmas de Gran Canaria, Spain
    Curr Allergy Asthma Rep 3:47-53. 2003
    ..This review focuses on our current understanding of the latex-fruit syndrome...
  35. ncbi Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes
    Piia Karisola
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    J Immunol 172:2621-8. 2004
    ..Hevein with a highly reduced ability to bind IgE should provide a valuable candidate molecule for immunotherapy of latex allergy and is anticipated to have a low risk of systemic side effects...
  36. ncbi Effect of reduced exposure on natural rubber latex sensitization in health care workers
    Franziska Rueff
    Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universitat, Munchen, Germany
    Ann Allergy Asthma Immunol 92:530-7. 2004
    ..Knowledge about the long-term course of allergy or sensitization to natural rubber latex (NRL) is insufficient...
  37. ncbi A clinical and serological follow-up study of health care workers allergic to natural rubber latex who had followed a latex avoidance programme
    M L Hemery
    Exploration des Allergies, Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier Cedex 5, France
    Allergy 59:1013-4. 2004
  38. ncbi Conversion to low-protein, powder-free surgical gloves: is it worth the cost?
    Denise M Korniewicz
    University of Miami, School of Nursing and Health Studies, Miami, FL, USA
    AAOHN J 53:388-93. 2005
    ..This study demonstrated that conversion to the use of powder-free, low-protein NRL gloves not only reduces health care worker NRL symptoms, but also positively affects the costs of glove purchases and workers' compensation...
  39. ncbi Percutaneous reactivity to natural rubber latex proteins persists in health-care workers following avoidance of natural rubber latex
    A M Smith
    Department of Internal Medicine, Division of Allergy Immunology, University of Cincinnati, Cincinnati, OH, USA
    Clin Exp Allergy 37:1349-56. 2007
    ..Percutaneous sensitivity to eight Hev b NRL allergens was evaluated in HCWs in 2000. To date, no studies have evaluated the longitudinal effects of NRL avoidance on percutaneous sensitivity to NRL allergens...
  40. ncbi Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study
    E Nettis
    Department of Clinical Medicine, Immunology and Infectious Deseases, University of Bari, Bari, Italy
    Br J Dermatol 156:674-81. 2007
    ..Natural rubber latex (NRL) allergy is a worldwide problem. Although prevention is sufficient to reduce sensitization, prolonged avoidance is needed to prevent resensitization or adverse reactions on re-exposure...
  41. ncbi Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population
    R Cremer
    Children s Hospital, Kliniken der Stadt Köln gGmbH, Cologne, Germany
    Eur J Pediatr Surg 17:194-8. 2007
    ..In this setting the influence of surgery and anaesthesia on NRL-sensitisation was investigated...
  42. ncbi Glove powder in the hospital environment -- consequences for healthcare workers
    Greta Edelstam
    Department of Obstetrics and Gynaecology, Karolinska Institute at Stockholm Söder Hospital, 118 83 Stockholm, Sweden greta edelstam kk sos sll se
    Int Arch Occup Environ Health 75:267-71. 2002
    ..To evaluate and take care of this problem at Stockholm Söder Hospital we carried out this study...
  43. ncbi Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization?
    M Raulf-Heimsoth
    Research Institute of Occupational Medicine of the Berufsgenossenschaften BGFA, Ruhr University Bochum, Bochum, Germany
    Allergy 62:1277-81. 2007
    ..Chestnut and natural rubber latex (NRL) allergy are often associated in the latex-fruit syndrome...
  44. ncbi Characterization of cross-reactive bell pepper allergens involved in the latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Allergy 34:1739-46. 2004
    ..Simultaneous sensitization to latex and bell pepper has been previously reported. Although bell pepper fruits are frequently consumed raw, cooked or as a spice, little is known about the cross-reactive allergens...
  45. ncbi Workers' compensation claims from latex glove use: a longitudinal analysis of Minnesota data from 1988 to 1997
    I B Horwitz
    Industrial Relations Center, University of Minnesota, Minneapolis, USA
    J Occup Environ Med 42:932-8. 2000
    ..Using empirical cost data from another study, it was found that it is not cost-beneficial for health care institutions to globally adopt latex glove-free policies solely on the basis of workers' compensation costs...
  46. ncbi Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome
    Annick Barre
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France
    Mol Immunol 46:1595-604. 2009
    ..Additionally, surface-exposed regions with a very close conformation were predicted to occur on Ole e 9, the 1,3beta-glucanase allergen identified in olive pollen...
  47. ncbi Latex allergy within a cohort of not-at-risk subjects with respiratory symptoms: prevalence of latex sensitization and assessment of diagnostic tools
    Adriano Mari
    Center of Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Int Arch Allergy Immunol 143:135-43. 2007
    ..Many cases of NRL allergy remain undiagnosed due to misreporting of symptoms by the patients or lack of proper questions asked by the physician...
  48. ncbi Hevea brasiliensis latex allergens: current panel and clinical relevance
    Stefan Wagner
    Center of Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 136:90-7. 2005
    ..In this review, we summarize current knowledge on the immunological properties of the 13 officially accepted Hevea brasiliensis latex allergens...
  49. ncbi Assessing latex allergy among health care employees using workers' compensation data
    I B Horwitz
    University of Minnesota's Industrial Relations Center, USA
    Minn Med 84:47-50. 2001
    ..08 per health care worker. Skin disorders were the most commonly reported condition. These findings are compared with previous studies of Minnesota and Rhode Island and demonstrate similar results...
  50. ncbi Strategies for distinguishing asymptomatic latex sensitization from true occupational allergy or asthma
    Dennis R Ownby
    Section of Allergy and Immunology, Medical College of Georgia, Augusta 30912 3790, USA
    Ann Allergy Asthma Immunol 90:42-6. 2003
    ..To evaluate strategies for distinguishing those individuals with true occupational asthma caused by exposure to natural rubber latex from those individuals with allergic disease related to other allergens...
  51. pmc Health care worker disability due to latex allergy and asthma: a cost analysis
    V L Phillips
    Department of Health Policy and Management, Rollins School of Public Health of Emory University, Atlanta, GA 30322, USA
    Am J Public Health 89:1024-8. 1999
    ....
  52. ncbi Occupational allergies caused by latex
    Debra D Fett Ahmed
    Indiana University Dermatology Clinic, 550 North University Boulevard, Suite 3240, Indianapolis, IN 46202, USA
    Immunol Allergy Clin North Am 23:205-19. 2003
    ..Optimal management of latex allergy involves education concerning cross-reacting allergens, reduction of cutaneous or mucosal contact with dipped rubber products, and minimization of exposure to latex aeroallergens in work environments...
  53. ncbi Basophil Activation Test and specific IgE measurements using a panel of recombinant natural rubber latex allergens to determine the latex allergen sensitization profile in children
    Maria L Sanz
    Department of Allergology and Clinical Immunology, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Pediatr Allergy Immunol 17:148-56. 2006
    ..BAT and allergen-specific IgE determination could be used as first-line in vitro diagnostic tests in patients with NRL allergy...
  54. ncbi Diagnosis of latex hypersensitivity: comparison of different methods
    Claudia Suli
    U O Medicina Interna 2, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Fondazione IRCCS, Milano, Italy
    Eur Ann Allergy Clin Immunol 38:24-30. 2006
    ..Patch testing with rubber chemicals should be reserved to selected cases. Basophil histamine release and immunoblotting can be performed for research purpose, but cannot be recommended for routine diagnostic use...
  55. ncbi The hevein domain of the major latex-glove allergen Hev b 6.01 contains dominant T cell reactive sites
    H D de Silva
    Co operative Research Centre for Asthma, Sydney, Australia
    Clin Exp Allergy 34:611-8. 2004
    ..As the immune response to allergens is initiated by activation of allergen-specific CD4(+) T cells, identification of dominant T cell epitopes is crucial for the development of specific immunotherapy...
  56. ncbi Allergic contact dermatitis from natural rubber latex in atopic dermatitis and the risk of later Type I allergy
    G Guillet
    Department of Dermatology and Venereology, Centre Hospitalo Universitaire de Poitiers, Poitiers, France
    Contact Dermatitis 53:46-51. 2005
    ..Children with AD are at high risk for allergy to NRL protein. Exclusion of this allergen should be strongly advised in atopics because of the dual risk of dermatitis and later evolution into severe Type I hypersensitivity...
  57. ncbi Latex allergens
    Jay E Slater
    U S Food and Drug Administration, Bethesda, Maryland, USA
    Clin Allergy Immunol 18:369-86. 2004
  58. ncbi Latex-vegetable syndrome due to custard apple and aubergine: new variations of the hevein symphony
    P M Gamboa
    Servicio de Alergia, Hospital de Basurto, Bilbao, Spain
    J Investig Allergol Clin Immunol 15:308-11. 2005
    ..In fact, no band was detected using the serum of patient 2 in avocado or aubergine extracts. By contrast, Prs a 1 reached high values of basophil activation and over 10% of histamine release in case 2...
  59. ncbi [Latex allergy, contact urticaria, anaphylaxis, latex-fruit syndrome, powder-free gloves]
    Akiko Yagami
    Department of Dermatology, Fujita Health University School of Medicine
    Nihon Rinsho 63:173-8. 2005
  60. ncbi Effect of omalizumab in health care workers with occupational latex allergy
    Francisque Leynadier
    J Allergy Clin Immunol 113:360-1. 2004
  61. ncbi Allergen specific nasal challenge to latex in children with latex allergy: clinical and immunological evaluation
    R Bernardini
    Pediatric Allergy and Pulmonology Center, Department of Pediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano 13, Florence, Italy
    Int J Immunopathol Pharmacol 21:333-41. 2008
    ..MFNS premedication before an ASNCL may prevent some immunological responses induced by ASNCL without clinical allergic modifications...
  62. ncbi Cross-reactivity between obeche wood (Triplochiton scleroxylon) and natural rubber latex
    M Venturini
    Dept of Allergy and Immunology, Santiago Apostol Hospital, Vitoria Gasteiz, Spain
    Allergy 59:225-8. 2004
    ..We have investigated a possible cross reactivity with a tree belonging to the Sterculiaceae family, Tryplochiton scleroxylon, in a patient allergic to obeche wood, that began to suffer symptoms of allergy in contact with latex...
  63. ncbi Identification of hevamine and hev B 1 as major latex allergens in Taiwan
    Mey Fann Lee
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Int Arch Allergy Immunol 139:38-44. 2006
    ..Allergen characterization of latex glove extract has never been studied in Taiwan. This study aimed to identify allergenic proteins from latex gloves...
  64. ncbi Natural rubber latex and hymenoptera venoms share ImmunoglobinE-epitopes accounting for cross-reactive carbohydrate determinants
    V Mahler
    Department of Dermatology, University of Erlangen Nuremberg, Erlangen, Germany
    Clin Exp Allergy 36:1446-56. 2006
    ..Xylose and core 3-fucose are typical complex glycans in plants and are foreign to mammals. Plant N-glycans and insect N-glycans may cross-react in humans...
  65. ncbi [Latex allergy in health care workers: frequency, exposure quantification, efficacy of criteria used for job fitness assessment]
    M Crippa
    Cattedra di Medicina del Lavoro, Scuola di Specializzazione in Medicina del Lavoro, Universita degli Studi di Brescia
    Med Lav 95:62-71. 2004
    ....
  66. doi Improving latex-allergy diagnosis: the clinical role of Hev b8-specific IgE
    L Antonicelli
    Allergy Unit, Department of Internal Medicine, Immuno Allergic and Respiratory Diseases, Ospedali Riuniti di Ancona, Ancona, Italy
    Allergy 63:620-1. 2008
  67. ncbi Latex allergen sensitization and risk factors due to glove use by health care workers at public health units in Florianopolis, Brazil
    Z S Buss
    Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Campus Universitario Trindade, Florianopolis, SC, Brazil
    J Investig Allergol Clin Immunol 17:27-33. 2007
    ..Natural rubber latex allergy is a "new" illness whose prevalence has reached epidemic proportions in highly exposed populations such as health care professionals...
  68. ncbi The en 455-3 modified lowry assay does not yield a reliable estimate of the allergenicity level of latex gloves with low total protein content
    Carine Audo
    Laboratoire Universitaire de Recherche en Immuno Allergologie LURIA, Centre d Allergologie, Hopital Tenon AP HP, Paris, France
    Med Sci Monit 10:PI81-6. 2004
    ..The Competitive Immunoassay for Antigenic Latex Proteins (CIALP) method described in a previous study could be a reliable complementary method for estimating the allergenicity of latex gloves...
  69. ncbi Latex allergy and skin
    Timo Reunala
    Department of Dermatology, University and University Hospital of Tampere, Tampere, Finland
    Curr Opin Allergy Clin Immunol 4:397-401. 2004
    ..In this review we address the prevalence and outcome of latex allergy in health care workers (HCWs). Recent findings in natural rubber latex (NRL) allergens and trials of specific immunotherapy (SIT) are also of interest...
  70. ncbi Differential expression of allergens on the internal and external surfaces of latex surgical gloves
    C Peixinho
    Health Sciences Research Centre, University of Beira Interior, Covilha, Portugal
    Allergol Immunopathol (Madr) 34:206-11. 2006
    ..The purpose of this study was to determine whether such sensitization profiles are associated with differences in the expression of latex allergen between the internal and external surfaces of surgical gloves...
  71. ncbi Sublingual immunotherapy with a latex extract in paediatric patients: a double-blind, placebo-controlled study
    Roberto Bernardini
    Paediatric Allergy and Pneumology Centre, Anna Meyer Children s Hospital, Florence, Italy
    Curr Med Res Opin 22:1515-22. 2006
    ..Specific immunotherapy can help to solve problems related to NRL allergy. So far, no controlled clinical trials have been performed in children suffering from NRL allergy...
  72. ncbi Investigative methods for natural rubber latex allergy in the UK
    J G Lowe
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Contact Dermatitis 52:11-3. 2005
    ..These findings suggest a need for robust guidance to achieve more consistent investigative practice by those dealing with this condition...
  73. ncbi Prevalence of type I allergy to natural rubber latex and type IV allergy to latex and rubber additives in operating room staff with glove-related symptoms
    Sara Miri
    Department of Laboratory Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Allergy Asthma Proc 28:557-63. 2007
    ..Based on this study, we recommend eliminating powdered latex gloves from the operating rooms of the 13 studied general hospitals and support the substitution of powder-free latex gloves...
  74. ncbi Characterization of B- and T-cell responses and HLA-DR4 binding motifs of the latex allergen Hev b 6.01 (prohevein) and its post-transcriptionally formed proteins Hev b 6.02 and Hev b 6.03
    M Raulf-Heimsoth
    Research Institute for Occupational Medicine of the Berufsgenossenschaften BGFA, Institute of the Ruhr University Bochum, Bochum, Germany
    Allergy 59:724-33. 2004
    ..01, Hev b 6.02 and Hev b 6.03 by using these allergens as recombinant maltose-binding fusion (MBP) proteins and the usage of synthetic modified hevein peptides...
  75. ncbi Type I latex allergy in health care workers with latex-induced contact urticaria syndrome: a follow-up study
    E Nettis
    Section of Allergy and Clinical Immunology, Department of Medical Clinic, Immunology and Infectious Diseases, University of Bari, Bari, Italy
    Allergy 59:718-23. 2004
    ..Latex allergy is an important occupational health issue among health care workers (HCWs). Secondary prevention in sensitized/allergic individuals involves avoiding exposure to NRL products...
  76. ncbi Latex allergy in healthcare workers: an epidemiological study in a Spanish hospital
    Maria Carmen Diéguez
    Servicio de Alergologia, Hospital Ramon y Cajal, Madrid, Spain
    Allergy Asthma Proc 28:564-70. 2007
    ..We should take into account these data to design an effective secondary prevention program...
  77. ncbi A study of natural rubber latex allergens in gloves used by healthcare workers in Singapore
    D Koh
    Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
    Br J Dermatol 153:954-9. 2005
    ..Allergy to natural rubber latex (NRL) proteins is a well-recognized health problem among subjects using protective gloves and products made of NRL. There is currently no information on NRL allergen levels in gloves used in Singapore...
  78. ncbi IgE-mediated natural rubber latex allergy: practical considerations for health care workers
    Didier G Ebo
    Department of Immunology, Allergology and Rheumatology, University of Antwerp, Antwerpen, Belgium
    Ann Allergy Asthma Immunol 88:568-75. 2002
    ....
  79. ncbi Management of occupational allergy to natural rubber latex in a medical center: the importance of quantitative latex allergen measurement and objective follow-up
    Loren W Hunt
    Allergic Diseases Research Laboratory and the Departments of Pediatrics and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Allergy Clin Immunol 110:S96-106. 2002
    ....
  80. ncbi Allergic reactions to natural rubber latex at home, to rubber products, and to cross-reacting foods
    John J Condemi
    Allergy Asthma Immunology of Rochester, NY 14618, USA
    J Allergy Clin Immunol 110:S107-10. 2002
    ..More attention should be devoted to reducing the antigens present in all NRL products and consideration given to developing vaccines for the food-sensitive individuals...
  81. ncbi Latex allergy: the perspective from the surgical suite
    Beth A Elliott
    Department of Anesthesiology, Mayo Medical School, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Allergy Clin Immunol 110:S117-20. 2002
    ....
  82. ncbi Tomato allergy in children and young adults: cross-reactivity with latex and potato
    M Reche
    Laboratorio de Inmunoalergia, Hospital Infantil La Paz, Castellana 261, 28046, Madrid, Spain
    Allergy 56:1197-201. 2001
    ..This protein could be implicated in the high cross-reactivity between tomato, latex, and potato observed in the immunoblot and CAP inhibition...
  83. ncbi [Latex allergy. Diagnosis and therapeutic aspects]
    A Sanchez Palacios
    Unidad de Alergologia, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain
    Allergol Immunopathol (Madr) 29:212-21. 2001
    ..These preliminary data encourage the hope that in the near future immunomodulatory therapy will be available to mitigate against the latex allergy epidemic...
  84. ncbi The prevalence of latex sensitisation and allergy in Danish atopic children. Evaluation of diagnostic methods
    Vagn Braendholt Jensen
    Department of Paediatrics, Gentofte University Hospital, Copenhagen, Denmark
    Dan Med Bull 49:260-2. 2002
    ..All over the world natural rubber allergy is reported to be responsible for a wide spectrum of allergic symptoms ranging from mild rhinitis to severe anaphylaxis...
  85. ncbi Prevalence of latex sensitization in health care workers of a general hospital in Palermo, Sicily
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Italy
    J Investig Allergol Clin Immunol 12:114-9. 2002
    ..To assess the prevalence of latex sensitization in a group of hospital employees in a general hospital...
  86. ncbi Identification of a Hevea brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen
    S Wagner
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 125:120-7. 2001
    ..brasiliensis which belongs to the 'latex-mold' group of latex allergens. Furthermore, it is a candidate for primary sensitization in patients allergic to the pan-allergen MnSOD...
  87. ncbi Latex allergy: past and present
    B Jean Meade
    National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA
    Int Immunopharmacol 2:225-38. 2002
    ....
  88. ncbi Epidemiology of latex sensitization and allergies in health care workers
    David H Garabrant
    Occupational Medicine, University of Michigan School of Public Health and University of Michigan School of Medicine, and the Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48104, USA
    J Allergy Clin Immunol 110:S82-95. 2002
    ..Future epidemiologic studies are needed that include measured exposures to latex antigens, that compare health care workers to appropriate referent groups, and that address confounding by atopy, age, sex, and race...
  89. ncbi Latex sensitization by dermal exposure can lead to airway hyperreactivity
    Michael D Howell
    Department of Microbiology and Immunology, West Virginia University, Morgantown, WV, USA
    Int Arch Allergy Immunol 128:204-11. 2002
    ....
  90. pmc Natural rubber latex allergy
    H Alenius
    Finnish Institute of Occupational Health, Helsinki, Finland
    Occup Environ Med 59:419-24. 2002
  91. ncbi IGE-mediated natural rubber latex allergy: an update
    D G Ebo
    Department of Immunology, Allergology and Rheumatology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen
    Acta Clin Belg 57:58-70. 2002
    ..7) How do we manage NRL allergy? What is the role of medication and immunotherapy in the treatment of NRL allergy? How do we select an appropriate non-NRL alternative for NRL gloves? Which regulatory provisions have been implemented?..
  92. ncbi Assessment of profilin as an allergen for latex-sensitized patients
    A Nieto
    Hospital Infantil La Fe, Valencia, Spain
    Allergy 57:776-84. 2002
    ..We studied the allergenic relevance of isolated latex natural and recombinant profilin, by in vivo and in vitro techniques, in two populations of spina bifida children (SB) and adults allergic to latex (AL)...
  93. ncbi Allergic and latex-specific sensitization: route, frequency, and amount of exposure that are required to initiate IgE production
    David N Weissman
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    J Allergy Clin Immunol 110:S57-63. 2002
    ....
  94. ncbi Specific monoclonal antibodies and human immunoglobulin E show that Hev b 5 is an abundant allergen in high protein powdered latex gloves
    M F Sutherland
    Department of Allergy, Asthma and Clinical Immunology, The Alfred Hospital and Monash University, Victoria, Australia
    Clin Exp Allergy 32:583-9. 2002
    ..Moreover, standardized immunological assays for the detection of Hev b 5 are currently lacking and may have important implications for both allergen avoidance and diagnosis in latex allergy...
  95. ncbi Addressing occupational allergy to natural rubber latex among health care workers
    John W Yunginger
    Ann Allergy Asthma Immunol 88:541-2. 2002
  96. ncbi Type I allergy to natural rubber latex and type IV allergy to rubber chemicals in health care workers with glove-related skin symptoms
    E Nettis
    Department of Medicine Clinic, Immunology and Infectious Diseases, Division of Allergy and Clinical Immunology, University of Bari, Italy
    Clin Exp Allergy 32:441-7. 2002
    ..It has been established that there are type I and type IV allergens in latex gloves...
  97. ncbi Incidence of sensitization, symptoms, and probable occupational rhinoconjunctivitis and asthma in apprentices starting exposure to latex
    S Archambault
    Department of Chest Medicine, , Montreal, Quebec, Canada
    J Allergy Clin Immunol 107:921-3. 2001
    ..The cumulative incidences for skin sensitization, probable occupational RC, and occupational asthma to latex were 6.4%, 1.8%, and 4.5%, respectively...
  98. ncbi Marked improvement of the basophil activation test by detecting CD203c instead of CD63
    R Boumiza
    Immunology Laboratory, Staff Health Department, Lyon Sud University Hospital, Lyon, France
    Clin Exp Allergy 33:259-65. 2003
    ..CD203c has recently been demonstrated as a specific activation marker of basophils that is rapidly up-regulated after allergen challenge in sensitized patients...
  99. ncbi Interest of two-dimensional electrophoretic analysis for the characterization of the individual sensitization to latex allergens
    H Chardin
    Institut Pasteur, Allergie et Environnement, Paris, France
    Int Arch Allergy Immunol 128:195-203. 2002
    ..The aim of the present investigation was to identify the major latex allergens by an individual analysis of the IgE response of latex-allergic patients to latex proteins separated by two-dimensional (2-D) gel electrophoresis...
  100. ncbi Prevention of latex allergy among health care workers: evaluation of the extractable latex protein content in different types of medical gloves
    Michela Crippa
    Institute of Occupational Health, University of Brescia, Italy
    Am J Ind Med 44:24-31. 2003
    ..The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were evaluated to acquire information useful for preventing latex allergy in our hospital personnel...
  101. ncbi Natural rubber latex allergy in a health-care population in Wales
    M M U Chowdhury
    Department of Dermatology, University Hospital of Wales, Box 100, Heath Park, Cardiff CF14 4XW, UK
    Br J Dermatol 148:737-40. 2003
    ..Type 1 natural rubber latex (NRL) allergy prevalence rates quoted vary due to the different populations studied and methodologies used for assessment and investigation of NRL allergy...

Research Grants19

  1. PREVENTION OF ALLERGIC RESPONSE TO LATEX RUBBER
    MELVIN KEYES; Fiscal Year: 1993
    ..Rates of latex hypersensitivity for hospital physicians and nurses are estimated to be about 3% while surgical units have a 6% or higher ..
  2. Keratinocyte Costimulation and Th2-Cell Immune Deviation
    Anthony Gaspari; Fiscal Year: 2009
    ..Similar mechanistic studies of the molecular basis of other skin diseases such as psoriasis have led to the development of biological response modifiers that are now in clinical use. ..
  3. DNA-linked dendrimer nanoparticle systems for cancer diagnosis and treatment
    James Baker; Fiscal Year: 2009
    ..This medicine would selectively target only the cancer, thereby avoiding the nausea, hair loss and illness caused by regular cancer chemotherapy. ..
  4. Nanoscale Investigations of Membranes (RMI)
    James Baker; Fiscal Year: 2004
    ..The application of nanoscience to membrane structure and transport will yield unique scientific discovery and help to improve medical care. ..
  5. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2005
    ..The projects are supported by a DEP collection and fractionation core, a mouse core, and a administrative, patient and sample coordination core. ..
  6. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    ....
  7. TRAINING OF ALLERGY & CLINICAL IMMUNOLOGY FELLOWS
    James Baker; Fiscal Year: 2004
    ..abstract_text> ..
  8. Endotoxin Exposure Alters-Anti-Tetanus IgE in Infants
    Dennis Ownby; Fiscal Year: 2009
    ..The closer temporal relationship should produce a clearer understanding of role of early environmental exposures on the development of allergic disease. ..
  9. APOPTOSIS IN THYROIDITIS
    James Baker; Fiscal Year: 2008
    ..These studies will clarify how thyroid cells are damaged by autoimmune responses and provide new approaches for predicting individuals at risk and developing therapeutic intervention. ..
  10. Medical workplace exposures, atopy and asthma in nurses
    Maria Mirabelli; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. Photonic Crystal Fiber Probe Fluorescence Biosensing
    James Baker; Fiscal Year: 2007
    ..unreadable] [unreadable] At the end of these studies, this technology will be at a point where it is ready for commercialization. [unreadable] [unreadable]..
  12. Allergy Therapy with Chimeric Human Ig Proteins
    Andrew Saxon; Fiscal Year: 2007
    ..Further, understanding of the mechanisms underlying the control of activating receptors by inhibitory receptors will have broad reaching implications for the manipulation the immune response. ..
  13. CLINICAL AND FUNDAMENTAL IMMUNOLOGY
    Andrew Saxon; Fiscal Year: 2006
    ..abstract_text> ..
  14. DEMOLITION AND ASTHMA IN CHICAGO PUBLIC HOUSING
    Samuel Dorevitch; Fiscal Year: 2006
    ....
  15. Antibiotics in Infancy-Risk Factor for Childhood Asthma
    Dennis Ownby; Fiscal Year: 2002
    ..This new analysis will allow a much more rigorous examination of the possible relationship between early antibiotic use and asthma in a population of American children. ..
  16. Cancer in Older Minority Populations
    Alfred Neugut; Fiscal Year: 2003
    ..Coordination of this P20 will be facilitated by the geographic proximity of the two institutions, their scientific strengths, and their commitment to similar programs. ..
  17. COLORECTAL CANCER AND OTHER CANCERS OF THE GI TRACT
    Alfred Neugut; Fiscal Year: 2005
    ..abstract_text> ..
  18. Targeted Magnetic Contrast Agent for MRI / SQUID Imaging
    James Baker; Fiscal Year: 2005
    ..This approach allows the imagining of pre-clinical lesions, and paves the way for intracellular delivery of functional imaging agents. ..
  19. STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
    Robert Brown; Fiscal Year: 2003
    ....