food hypersensitivity

Summary

Summary: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.

Top Publications

  1. ncbi Food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:S116-25. 2010
  2. pmc Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel
    Joshua A Boyce
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 126:S1-58. 2010
  3. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
  4. ncbi Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
    Nicholas J Osborne
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Allergy Clin Immunol 127:668-76.e1-2. 2011
  5. ncbi Food allergy among children in the United States
    Amy M Branum
    Infant, Child, and Women s Health Statistics Branch, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782 2003, USA
    Pediatrics 124:1549-55. 2009
  6. ncbi Fatalities due to anaphylactic reactions to foods
    S A Bock
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    J Allergy Clin Immunol 107:191-3. 2001
  7. ncbi The prevalence, severity, and distribution of childhood food allergy in the United States
    Ruchi S Gupta
    Institute for Healthcare Studies, Department of Pediatrics, Northwestern University Feinberg School of Medicine, and Smith Child Health Research Program, Division of Allergy and Immunology, Children s Memorial Hospital, Chicago, Illinois 60640, USA
    Pediatrics 128:e9-17. 2011
  8. ncbi Further fatalities caused by anaphylactic reactions to food, 2001-2006
    S Allan Bock
    J Allergy Clin Immunol 119:1016-8. 2007
  9. ncbi Anaphylaxis fatalities and admissions in Australia
    Woei Kang Liew
    Department of Allergy and Immunology, Melbourne, Australia
    J Allergy Clin Immunol 123:434-42. 2009
  10. ncbi Further fatal allergic reactions to food in the United Kingdom, 1999-2006
    Richard S H Pumphrey
    J Allergy Clin Immunol 119:1018-9. 2007

Detail Information

Publications333 found, 100 shown here

  1. ncbi Food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 125:S116-25. 2010
    ..Improved therapeutic strategies under study include oral and sublingual immunotherapy, Chinese herbal medicine, anti-IgE antibodies, and modified vaccines...
  2. pmc Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel
    Joshua A Boyce
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 126:S1-58. 2010
    ..They also identify gaps in the current scientific knowledge to be addressed through future research...
  3. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
    ..There is uncertainty about the prevalence of food allergy in communities...
  4. ncbi Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
    Nicholas J Osborne
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Allergy Clin Immunol 127:668-76.e1-2. 2011
    ..Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level...
  5. ncbi Food allergy among children in the United States
    Amy M Branum
    Infant, Child, and Women s Health Statistics Branch, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782 2003, USA
    Pediatrics 124:1549-55. 2009
    ..The goals were to estimate the prevalence of food allergy and to describe trends in food allergy prevalence and health care use among US children...
  6. ncbi Fatalities due to anaphylactic reactions to foods
    S A Bock
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    J Allergy Clin Immunol 107:191-3. 2001
    ..In this series, peanuts and tree nuts accounted for more than 90% of the fatalities. Improved education of the profession, allergic individuals, and the public will be necessary to stop these tragedies...
  7. ncbi The prevalence, severity, and distribution of childhood food allergy in the United States
    Ruchi S Gupta
    Institute for Healthcare Studies, Department of Pediatrics, Northwestern University Feinberg School of Medicine, and Smith Child Health Research Program, Division of Allergy and Immunology, Children s Memorial Hospital, Chicago, Illinois 60640, USA
    Pediatrics 128:e9-17. 2011
    ..The goal of this study was to better estimate the prevalence and severity of childhood food allergy in the United States...
  8. ncbi Further fatalities caused by anaphylactic reactions to food, 2001-2006
    S Allan Bock
    J Allergy Clin Immunol 119:1016-8. 2007
  9. ncbi Anaphylaxis fatalities and admissions in Australia
    Woei Kang Liew
    Department of Allergy and Immunology, Melbourne, Australia
    J Allergy Clin Immunol 123:434-42. 2009
    ..Detailed data on fatal anaphylaxis are limited, with national anaphylaxis fatality data for the United Kingdom and food-induced anaphylaxis fatality data for the United States. Time trends for anaphylaxis fatalities are not available...
  10. ncbi Further fatal allergic reactions to food in the United Kingdom, 1999-2006
    Richard S H Pumphrey
    J Allergy Clin Immunol 119:1018-9. 2007
  11. ncbi Fish consumption during the first year of life and development of allergic diseases during childhood
    I Kull
    Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Allergy 61:1009-15. 2006
    ..However, methodological limitations in the studies make conclusions uncertain. The aim of this study was to assess the association between fish consumption during the first year of life and development of allergic diseases by age 4...
  12. ncbi Work Group report: oral food challenge testing
    Anna Nowak-Wegrzyn
    Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 123:S365-83. 2009
    ..A negative oral food challenge result allows introduction of the food into the diet, whereas a positive oral food challenge result provides a sound basis for continued avoidance of the food...
  13. ncbi The incidence and risk factors of immediate type food allergy during the first year of life in Korean infants: a birth cohort study
    Jihyun Kim
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Pediatr Allergy Immunol 22:715-9. 2011
    ..We conducted this study to determine the incidence of food allergy (FA) in Korean infants and identify the risk factors of FAs during the first year of life in a birth cohort study...
  14. ncbi Paediatric food allergy trends in a community-based specialist allergy practice, 1995-2006
    Raymond J Mullins
    John James Medical Centre, Canberra, ACT, Australia
    Med J Aust 186:618-21. 2007
    ..To examine changing demand for specialist food allergy services for children aged 0-5 years over the 12 years from 1995 to 2006 as an index of changing prevalence...
  15. ncbi Food allergy and probiotics in childhood
    Michele Miraglia del Giudice
    Dipartimento di Pediatria, Seconda Universita di Napoli, Napoli, Italy
    J Clin Gastroenterol 44:S22-5. 2010
    ..These differences are probably related to differences in selected populations and in probiotic strains used...
  16. pmc Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial
    W Atkinson
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 53:1459-64. 2004
    ..Tests attempting to predict food sensitivity in IBS have been disappointing but none has utilised IgG antibodies...
  17. ncbi The prevalence of allergy to egg: a population-based study in young children
    M Eggesbø
    National Institute of Public Health, Section of Epidemiology, Department of Population Health Sciences, Oslo, Norway
    Allergy 56:403-11. 2001
    ..The aim of the present study was to estimate the prevalence of adverse reactions to egg, as population-based prevalence estimates based on objective diagnostic procedures are lacking...
  18. ncbi Standardization of food challenges in patients with immediate reactions to foods--position paper from the European Academy of Allergology and Clinical Immunology
    C Bindslev-Jensen
    Allergy Center, Odense University Hospital, Odense, Denmark
    Allergy 59:690-7. 2004
  19. ncbi Food protein-induced enterocolitis syndrome caused by solid food proteins
    Anna Nowak-Wegrzyn
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Pediatrics 111:829-35. 2003
    Infantile food protein-induced enterocolitis syndrome (FPIES) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow's milk or soy. Solid foods are rarely considered a cause.
  20. ncbi Epidemiology of food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 127:594-602. 2011
    ..Recent and ongoing studies provide insights on risk factors, prevalence, and natural course that may inform clinical trials to improve diagnosis, prevention, and treatment...
  21. pmc Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood
    Xiumei Hong
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, IL 60614, USA
    J Allergy Clin Immunol 128:374-81.e2. 2011
    ..The effect of breast-feeding on the development of allergic disease is uncertain. There are no data that show whether this relationship varies by individual genotypes...
  22. ncbi Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy
    Catrin Furuhjelm
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Paediatr 98:1461-7. 2009
    ..Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy...
  23. ncbi Fatty acid deficiency profile in children with food allergy managed with elimination diets
    Luis Aldámiz-Echevarría
    Divisions of Metabolism, Department of Pediatrics, Hospital de Cruces, Basque University School of Medicine, Bilbao, Pais Vasco, Spain
    Acta Paediatr 97:1572-6. 2008
    ..To evaluate plasma fatty acid (FA) composition of children with food allergy undergoing elimination diets that avoided the offending antigens...
  24. ncbi Season of birth and childhood food allergy in Australia
    Raymond James Mullins
    John James Medical Centre, Deakin, ACT, Australia
    Pediatr Allergy Immunol 22:583-9. 2011
    ..We hypothesized that children born in autumn/winter months (less sun exposure) might have higher food allergy rates than those born in spring/summer...
  25. ncbi Clinical diagnosis and management of food protein-induced enterocolitis syndrome
    Stephanie A Leonard
    Department of Pediatrics, Division of Allergy and Immunology, University of California, San Diego, California, USA
    Curr Opin Pediatr 24:739-45. 2012
    ..of food protein-induced enterocolitis syndrome (FPIES), an under-recognized and often misdiagnosed nonimmunoglobulin E-mediated food hypersensitivity. This review will highlight updates on natural history and clinical management.
  26. ncbi Food allergy: review, classification and diagnosis
    Antonella Cianferoni
    Division of Allergy and Immunology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Allergol Int 58:457-66. 2009
    ..However, novel strategies are being studied, including sublingual/oral immunotherapy and others with a hope for future...
  27. ncbi The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability
    N J Osborne
    Gut and Liver, Murdoch Childrens Research Institute, Melbourne, Vic, Australia
    Clin Exp Allergy 40:1516-22. 2010
    ..However, a valid measure of food allergy prevalence and risk factor data from a population-based study is still lacking...
  28. pmc Health-related quality of life among adolescents with allergy-like conditions - with emphasis on food hypersensitivity
    Birgitta Marklund
    Centre for Allergy Research, Karolinska Institutet, S 171 77 Solna, Sweden
    Health Qual Life Outcomes 2:65. 2004
    ..Furthermore, studies on food hypersensitivity and quality of life are scarce...
  29. ncbi In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars
    Suzanne T H P Bolhaar
    Department of Dermatology, University Hospital Utrecht, The Netherlands
    J Allergy Clin Immunol 116:1080-6. 2005
    ..Apple cultivars have been reported to differ in allergenicity on the basis of in vitro and skin prick tests with apple extracts...
  30. ncbi Does the microbiota regulate immune responses outside the gut?
    Mairi C Noverr
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Trends Microbiol 12:562-8. 2004
    ..review covers the post-developmental functions that the microbiota plays in regulating immunological tolerance to allergen exposure outside the GI tract and proposes the question: is the microbiota a major regulator of the immune system?..
  31. pmc Probiotics and food allergy
    Anna Maria Castellazzi
    Department of Medical and Pediatric Science, University of Catania, Catania, Italy
    Ital J Pediatr 39:47. 2013
    ..Therefore, new studies are needed in order to clarify the functions and the utility of probiotics in food allergies and ion other types of allergic disorders. ..
  32. ncbi Food protein-induced enterocolitis syndrome: an update on natural history and review of management
    Stephanie A Leonard
    Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 107:95-101; quiz 101, 162. 2011
    ..To review the clinical features, pathophysiology, and management of food protein-induced enterocolitis syndrome (FPIES) and to discuss new observations in epidemiology and natural history...
  33. pmc Gene-vitamin D interactions on food sensitization: a prospective birth cohort study
    X Liu
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Allergy 66:1442-8. 2011
    ..However, the epidemiological evidence is conflicting. We aim to examine whether cord blood VDD is associated with FS and whether such association can be modified by genetic variants in a prospective birth cohort...
  34. pmc Season of birth and food allergy in children
    Milo F Vassallo
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Allergy Asthma Immunol 104:307-13. 2010
    ..Based on seasonal patterns of UV-B exposure (and consequent vitamin D status), we hypothesized that patients with food allergy are more often born in fall or winter...
  35. pmc Cow's milk protein allergy in children: a practical guide
    Carlo Caffarelli
    Dipartimento dell Eta Evolutiva, Clinica Pediatrica Università di Parma, Parma, Italy
    Ital J Pediatr 36:5. 2010
    ..An overview of acceptable means for diagnosis is included. According to symptoms and infant diet, three different algorithms for diagnosis and follow-up have been suggested...
  36. pmc National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006
    Andrew H Liu
    National Jewish Health and University of Colorado Denver School of Medicine, Denver, CO, USA
    J Allergy Clin Immunol 126:798-806.e13. 2010
    ..The national prevalence and patterns of food allergy (FA) in the United States are not well understood...
  37. ncbi The EuroPrevall birth cohort study on food allergy: baseline characteristics of 12,000 newborns and their families from nine European countries
    D McBride
    Institute of Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    Pediatr Allergy Immunol 23:230-9. 2012
    ..Using standardized questionnaires, we assessed allergic diseases and self-reported food hypersensitivity of parents and siblings, nutrition during pregnancy, nutritional supplements, medications, mode of ..
  38. ncbi Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
    ..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
  39. ncbi Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life
    C Venter
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight, UK
    Allergy 63:354-9. 2008
    Prevalence and incidence of food hypersensitivity (FHS) and its trends in early childhood are unclear.
  40. ncbi Food protein-induced enterocolitis syndrome--not only due to cow's milk and soy
    Yael Levy
    Kipper Institute of Immunology, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Allergy Immunol 14:325-9. 2003
    ..All were negative. Pediatricians should be aware that FPIES may be caused by foods other than cow's milk and soy, mainly chicken, turkey and foods from the legume family, and that it may present also in infants older than 6 months...
  41. ncbi Is delivery by cesarean section a risk factor for food allergy?
    Merete Eggesbø
    Norwegian Institute of Public Health, Division of Epidemiology, Oslo, Norway
    J Allergy Clin Immunol 112:420-6. 2003
    ..Cesarean delivery might delay the colonization of the newborn intestine. A delayed or aberrant colonization process has been offered as an explanation for the increase in allergic diseases...
  42. pmc NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population
    A Wesley Burks
    Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatrics 128:955-65. 2011
    ..To focus on those concerns, we describe here the guidelines most pertinent to the pediatric population...
  43. ncbi False-negative food challenges in children with suspected food allergy
    C Caffarelli
    Paediatric Department, University of Parma, 43100, Parma, Italy
    Lancet 358:1871-2. 2001
    ..Our findings suggest that open feedings under observation, the day after negative challenges, are useful to eliminate false-negative challenge results...
  44. ncbi Food allergy and non-allergic food hypersensitivity in children and adolescents
    C C Roehr
    Department of Pediatric Pneumology and Immunology, University Hospital Charite, Humboldt University, Berlin, Germany
    Clin Exp Allergy 34:1534-41. 2004
    ..studies have shown a 10-fold discrepancy of self-reported food-induced symptoms and physician-diagnosed food hypersensitivity. Little information is available on the prevalence of food hypersensitivity in unselected paediatric ..
  45. ncbi Gut permeability and food allergies
    C Perrier
    Division of Gastroenterology, University Hospital, Catholic University Leuven, Leuven, Belgium
    Clin Exp Allergy 41:20-8. 2011
    ..We conclude by speculating on the effect of increased intestinal permeability on the onset of sensitization towards dietary antigens...
  46. ncbi Polyphenol-enriched apple extract attenuates food allergy in mice
    A W Zuercher
    Allergy Group, Department of Nutrition and Health, Nestle Research Center, Lausanne, Switzerland
    Clin Exp Allergy 40:942-50. 2010
    ..The immune system may be modulated with nutrition to prevent the development or to treat the symptoms of allergy. Among other foods, consumption of apples has been linked to reduced incidence of atopic dermatitis and respiratory allergy...
  47. ncbi Microarray of allergenic component-based diagnosis in food allergy
    Maria L Sanz
    Departamento de Alergología e Inmunología Clínica, Clinica Universidad de Navarra, Pamplona, Spain
    Curr Opin Allergy Clin Immunol 11:204-9. 2011
    ..In this review, we will analyze the results obtained to date with this technology applied to the component-based diagnosis of food allergy...
  48. ncbi Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene
    Troy R Torgerson
    University of Washington and Children s Hospital, Department of Pediatrics, Division of Immunology, Rheumatology, and Infectious Diseases, Seattle, Washington, USA
    Gastroenterology 132:1705-17. 2007
    ..In the present work, we aimed to uncover the molecular basis of a distinct form of IPEX syndrome presenting at the edge of autoimmunity and severe allergy...
  49. ncbi Correlation of allergen-specific IgG subclass antibodies and T lymphocyte cytokine responses in children with multiple food allergies
    Tim H Scott-Taylor
    Division of Immunobiology, Institute of Child Health, London, UK
    Pediatr Allergy Immunol 21:935-44. 2010
    ..IgG1:IgG4 ratio declines with allergy sensitization and may denote emerging tolerance...
  50. ncbi An oral sensitization model in Brown Norway rats to screen for potential allergenicity of food proteins
    L M Knippels
    Department of Target Organ Toxicology, TNO Nutrition and Food Research Institute, AJ Zeist, 3700, The Netherlands
    Methods 19:78-82. 1999
    ....
  51. ncbi Utility of food-specific IgE concentrations in predicting symptomatic food allergy
    H A Sampson
    Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 107:891-6. 2001
    ....
  52. ncbi Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial
    Lidy M Pelsser
    ADHD Research Centre, Eindhoven, Netherlands
    Lancet 377:494-503. 2011
    ..We aimed to investigate whether there is a connection between diet and behaviour in an unselected group of children...
  53. ncbi Food allergy diagnostics: scientific and unproven procedures
    Kirsten Beyer
    Children s Hospital Charité, Humboldt University, Berlin, Germany
    Curr Opin Allergy Clin Immunol 5:261-6. 2005
    ..This review covers some of the most common scientifically validated and unproven approaches used in the diagnosis of food allergy...
  54. ncbi The diagnosis of food allergy in children
    Roberto Berni Canani
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Pediatr 20:584-9. 2008
    ..To give an update about the optimal diagnostic work-up for children with suspected food allergy...
  55. ncbi nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of Sin a 3 and Sin a 4
    S Sirvent
    Departament of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain
    Clin Exp Allergy 39:1929-36. 2009
    ..Patients allergic to mustard are frequently sensitized to peach...
  56. ncbi Teenagers' experiences of living with food hypersensitivity: a qualitative study
    Heather MacKenzie
    School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK
    Pediatr Allergy Immunol 21:595-602. 2010
    ..This study aimed to describe the lived experiences of teenagers with food hypersensitivity. Individual semi-structured interviews were conducted with 21 teenagers (13-18 yr) with food ..
  57. ncbi Food: the forgotten factor in the irritable bowel syndrome
    Shanti Eswaran
    Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 5362, USA
    Gastroenterol Clin North Am 40:141-62. 2011
    ..This article reviews the literature supporting a causal link between food and the symptoms of IBS as well as the evidence supporting dietary interventions as a means of managing IBS symptoms...
  58. ncbi A mouse model for food allergy using intraperitoneal sensitization
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Methods 41:91-8. 2007
    ..Progress to date with this method is summarized, and comparisons are made with other experimental models, including considerations of route of exposure, use of adjuvants and selection of appropriate end points...
  59. ncbi The latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, Austria
    Biochem Soc Trans 30:935-40. 2002
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  60. pmc Towards a cure for food allergy
    Justin M Skripak
    Mount Sinai School of Medicine, New York, NY, United States
    Curr Opin Immunol 20:690-6. 2008
    ..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
  61. ncbi Identification of IgE-binding epitopes of the major peach allergen Pru p 3
    Gloria García-Casado
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, Ciudad Universitaria, 28040 Madrid, Spain
    J Allergy Clin Immunol 112:599-605. 2003
    ..Pru p 3, the major peach allergen in the Mediterranean area, is among the best-characterized allergenic members of the LTP family. Its diagnostic value for Rosaceae fruit allergy has been demonstrated both in vivo and in vitro...
  62. ncbi Diet and nutritional status of children with food allergies
    Sophie Flammarion
    Unité de pneumologie et allergologie pédiatriques, Departement de Pediatrie, Hopital Jeanne de Flandre, CHRU de Lille, Lille, France
    Pediatr Allergy Immunol 22:161-5. 2011
    ..Children with food allergies were smaller for their age than controls even when they received similar nutrient intakes. Nutritional evaluation is essential for the follow up of children with food allergies...
  63. ncbi Food protein-induced enterocolitis syndrome: case presentations and management lessons
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:149-56. 2005
    ..The purpose of this report is to delineate the characteristic clinical features and review the possible pathophysiologic basis to frame a rational strategy toward management...
  64. pmc Mechanisms of immune tolerance relevant to food allergy
    Brian P Vickery
    Division of Pediatric Allergy and Immunology, Duke University School of Medicine, Durham, NC 27710, USA
    J Allergy Clin Immunol 127:576-84; quiz 585-6. 2011
    ..Food allergy is among the clinical disorders that occur from a failure of this system, and therapies that seek to re-establish tolerance are currently under investigation...
  65. pmc Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure
    Philipp Neudecker
    Lehrstuhl für Biopolymere, Universitaet Bayreuth, Universitatsstrasse 30, 95440 Bayreuth, Germany
    Biochem J 376:97-107. 2003
    ....
  66. ncbi Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis
    C Anandan
    Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Allergy 64:840-8. 2009
    ..We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders...
  67. ncbi Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model
    K Shida
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Clin Exp Allergy 32:563-70. 2002
    ....
  68. ncbi The prevalence of food hypersensitivity in an unselected population of children and adults
    M Osterballe
    Allergy Center, Department of Dermatology, Odense University Hospital, Denmark
    Pediatr Allergy Immunol 16:567-73. 2005
    A rising prevalence of food hypersensitivity (FHS) and severe allergic reactions to food has been reported the last decade...
  69. pmc Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000
    Jae Won Oh
    Department of Pediatrics, Hanyang University, Korea
    J Korean Med Sci 19:716-23. 2004
    ..The further objective evaluations are required to confirm these outcomes because the environmental and risk factors may be different among the countries according to their living cultures...
  70. ncbi The role of lipid transfer proteins in allergic diseases
    Matthias Egger
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, Austria
    Curr Allergy Asthma Rep 10:326-35. 2010
    ..Molecule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy and could assist clinicians with providing adequate patient-tailored advice...
  71. ncbi Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial
    Ji Yeun Kim
    Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56 1, Shinlimdong, Kwanakku, Seoul, Korea
    Pediatr Allergy Immunol 21:e386-93. 2010
    ..bifidum BGN4, B. lactis AD011, and L. acidophilus AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life...
  72. ncbi An enteric helminth infection protects against an allergic response to dietary antigen
    Mohamed Elfatih H Bashir
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 169:3284-92. 2002
    ..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...
  73. ncbi Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition
    Carlo Agostoni
    Department of Pediatrics, San Paolo Hospital, University of Milano, Milano, Italy
    J Pediatr Gastroenterol Nutr 46:99-110. 2008
    ..Infants and young children receiving a vegetarian diet should receive a sufficient amount ( approximately 500 mL) of breast milk or formula and dairy products. Infants and young children should not be fed a vegan diet...
  74. ncbi Nomenclature and structural biology of allergens
    Martin D Chapman
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 119:414-20. 2007
    ..Structural biology and proteomics define recombinant allergen targets for diagnostic and therapeutic purposes and identify motifs, patterns, and structures of immunologic significance...
  75. ncbi Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder
    Harumi Jyonouchi
    Department of Pediatrics, University of Minnesota, Minneapolis, Minn, USA
    Neuropsychobiology 46:76-84. 2002
    ..This may predispose ASD children to sensitization to common dietary proteins (DP), leading to GI inflammation and aggravation of some behavioral symptoms...
  76. ncbi Expression of transforming growth factor beta1, transforming growth factor type I and II receptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome
    Hai Lee Chung
    Department of Pediatrics, Pathology, and Clinical Pathology, School of Medicine, Catholic University of Taegu, Korea
    J Allergy Clin Immunol 109:150-4. 2002
    ..TNF-alpha secreted by activated T cells is known to increase intestinal permeability, whereas transforming growth factor (TGF) beta has the ability to protect the epithelial barrier...
  77. ncbi Thaumatin-like proteins -- a new family of pollen and fruit allergens
    Heimo Breiteneder
    Allergy 59:479-81. 2004
  78. ncbi The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review
    A J Cummings
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, UK
    Allergy 65:933-45. 2010
    ..However, there is strong evidence that food allergy and food hypersensitivity has an impact on psychological distress and on the quality of life (QoL) of children and adolescents, as ..
  79. ncbi Evaluation of protein safety in the context of agricultural biotechnology
    Bryan Delaney
    Pioneer Hi Bred, A DuPont Company, Johnston, IA, USA
    Food Chem Toxicol 46:S71-97. 2008
    ....
  80. ncbi A novel approach for investigation of specific and cross-reactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients
    Diana Mittag
    Allergy Unit, Department of Dermatology, University Hospital Zurich, Switzerland
    Mol Immunol 43:268-78. 2006
    ..Moreover, patterns of IgE reactivity may be patient-specific. The aim of our study was to compare specific and cross-reactive IgE epitopes and epitope patterns between individual patients. We used Bet v 1-related food allergy as a model...
  81. ncbi A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge
    S T H P Bolhaar
    Department of Dermatology Allergology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Allergy 35:1638-44. 2005
    ..Allergen-specific immunotherapy for food allergy has been hindered by severe side-effects in the past. Well-characterized hypo-allergenic recombinant food allergens potentially offer a safe solution...
  82. pmc Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity
    A W Burks
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Clin Invest 96:1715-21. 1995
    ..With the production of the recombinant peanut protein it will now be possible to address the pathophysiologic and immunologic mechanisms regarding peanut hypersensitivity reactions specifically and food hypersensitivity in general
  83. ncbi Caesarean section delivery and the risk of allergic disorders in childhood
    H Renz-Polster
    Oregon Health and Science University, Portland OR, USA
    Clin Exp Allergy 35:1466-72. 2005
    ..Beneficial intestinal microbes originate from the maternal vaginal tract and thus are more likely to be transferred during vaginal births than during Caesarean sections (C-sections)...
  84. ncbi Food allergy QoL questionnaire for children aged 0-12 years: content, construct, and cross-cultural validity
    A DunnGalvin
    Department of Paediatrics and Child Health, University College, Cork, Ireland
    Clin Exp Allergy 38:977-86. 2008
    ..To date, there is no food allergy-specific questionnaire that allows parents to report children's health-related QoL (HRQL) from the child's perspective...
  85. ncbi Food hypersensitivity and irritable bowel syndrome
    S Zar
    Department of General Surgery, St George's Hospital Medical School, London, UK
    Aliment Pharmacol Ther 15:439-49. 2001
    ..There is no clinically useful marker available to test for food hypersensitivity in irritable bowel syndrome...
  86. ncbi Allergy and sports in children
    Stefano R Del Giacco
    Department of Medical Sciences M Aresu, University of Cagliari, Cagliari, Italy
    Pediatr Allergy Immunol 23:11-20. 2012
    ..The role of the immune system in exercise-induced immunoallergic syndromes, clinical aspects, and diagnostic and therapeutic approaches are discussed in this review...
  87. ncbi Evaluation of available IgE-binding epitope data and its utility in bioinformatics
    Gary A Bannon
    Monsanto Company, St Louis, Missouri, USA
    Mol Nutr Food Res 50:638-44. 2006
    ..Finally, bioinformatics methods to assess protein allergenicity using knowledge of IgE-binding epitopes are discussed...
  88. pmc Multicenter study of repeat epinephrine treatments for food-related anaphylaxis
    Susan A Rudders
    Division of Allergy and Immunology, Children s Hospital Boston, Boston, Massachusetts, USA
    Pediatrics 125:e711-8. 2010
    ..We sought to establish the frequency of receiving >1 dose of epinephrine in children who present to the emergency department (ED) with food-related anaphylaxis...
  89. ncbi [Fatal anaphylaxis after eating wild boar meat in a patient with pork-cat syndrome]
    M Drouet
    Laboratoire d'Immuno-Allergologie-CHU-49033 Angers, France
    Allerg Immunol (Paris) 33:163-5. 2001
    ..Co-factors, such as effort, taking alcohol or hormonal condition may complicate the picture to make diagnosis more difficult...
  90. ncbi Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via the oral route
    R Brunner
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Allergy 64:890-7. 2009
    ..These anti-acids have been shown to cause sensitization to food proteins via elevation of the gastric pH. The aim of this study was to assess the oral adjuvant properties of ALUM, alone or contained in SUC, in a BALB/c mouse model...
  91. ncbi Administration of epinephrine for life-threatening allergic reactions in school settings
    C Lynne McIntyre
    Division of Applied Statistics, Evaluation, and Technical Services, Massachusetts Department of Public Health, Boston, Massachusetts, USA
    Pediatrics 116:1134-40. 2005
    ....
  92. ncbi Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen
    Masako Toda
    Junior Research Group Experimental Allergy Models, Paul Ehrlich Institut, Langen, Germany
    J Allergy Clin Immunol 128:1022-30.e1-7. 2011
    ..Use of allergens with reduced allergenic potential and preserved immunogenicity could improve the safety and efficacy of allergen-specific immunotherapy...
  93. ncbi Birch-apple syndrome treated with birch pollen immunotherapy
    Marina Mauro
    Allergy Unit, Sant Anna Hospital, Como, Italy
    Int Arch Allergy Immunol 156:416-22. 2011
    ..We performed a randomized study on patients with birch-apple syndrome to evaluate the outcome of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT)...
  94. ncbi Allergenic reactivity of the melon profilin Cuc m 2 and its identification as major allergen
    G Lopez-Torrejon
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, Madrid, Spain
    Clin Exp Allergy 35:1065-72. 2005
    ..No melon allergen responsible for these clinical characteristics has yet been isolated, although profilin has been proposed as a potential target...
  95. ncbi The importance of early complementary feeding in the development of oral tolerance: concerns and controversies
    Susan L Prescott
    School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
    Pediatr Allergy Immunol 19:375-80. 2008
    ..It will also examine the growing case for introducing complementary foods from around 4 months of age and maintaining breastfeeding during this early feeding period, for at least 6 months if possible...
  96. ncbi Adverse reactions to foods
    Anna Nowak-Wegrzyn
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Med Clin North Am 90:97-127. 2006
    ..Anti-IgE monoclonal antibody is the first potential therapy for food allergy that is under-going testing in clinical trials...
  97. ncbi A prediction rule for food challenge outcome in children
    Kim Zomer-Kooijker
    Department of Paediatric Pulmonology and Allergology, University Medical Centre, Utrecht, Utrecht, The Netherlands
    Pediatr Allergy Immunol 23:353-9. 2012
    ..We aimed to determine questionnaire and test-based characteristics, to predict the food challenge outcome (FCO) in children referred to a tertiary centre for the evaluation of food-related symptoms...
  98. ncbi Food allergy: recent advances in pathophysiology and treatment
    Scott H Sicherer
    The Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Annu Rev Med 60:261-77. 2009
    ....
  99. ncbi A model of chronic IgE-mediated food allergy in ovalbumin-sensitized mice
    J C S Saldanha
    Departamento de Patologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Braz J Med Biol Res 37:809-16. 2004
    ..The experimental model described here reproduces the clinical and pathological changes of mild chronic food allergy and may be useful for mechanistic studies of this common clinical condition...
  100. ncbi Coordinated and standardized production, purification and characterization of natural and recombinant food allergens to establish a food allergen library
    Karin Hoffmann-Sommergruber
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Mol Nutr Food Res 52:S159-65. 2008
    ..The application of these methods and impact on the quality and performance of the final purified food allergens included in the EuroPrevall allergen library is discussed...
  101. ncbi A pilot study of interferon-gamma-induced specific oral tolerance induction (ISOTI) for immunoglobulin E-mediated anaphylactic food allergy
    Geunwoong Noh
    Department of Allergy and Clinical Immunology, Seoul Allergy Clinic, Seoul, Korea
    J Interferon Cytokine Res 29:667-75. 2009
    ..IFN-gamma may be an important cytokine in tolerance induction. Simultaneous allergen stimulation with nonspecific immunomodulation of IFN-gamma was essential for specific tolerance induction in IgE-mediated anaphylactic food allergy...

Research Grants62

  1. Immune Cell Responses in Food Hypersensitivity
    John Schroeder; Fiscal Year: 2009
    ..b>Food hypersensitivity in general is thought to result from a defect in either the induction or maintenance of oral tolerance...
  2. ALLERGENICITY OF MAJOR COMPONENT PROTEINS OF SOYBEAN
    ARVIL BURKS; Fiscal Year: 1993
    ..By studying adverse reactions to soy protein, one of the major causes of food hypersensitivity reactions, scientific information concerning antigen identification, characterization and the immunologic ..
  3. Tolerance Maintenance and its Breakdown in Food Allergy
    Talal Chatila; Fiscal Year: 2009
    ..The proposed studies would provide fundamental insights into the role of TR cell in tolerance maintenance to food allergens and mechanisms of food hypersensitivity pursuant to their deficiency.
  4. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  5. Gut Dendritic Cells and Allergic Sensitization
    M Berin; Fiscal Year: 2006
    ..The results from these experiments will provide a better understanding of how a normally tolerogenic response to a food protein deviates toward allergic sensitization. [unreadable] [unreadable]..
  6. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ....
  7. Effects of Chinese Herbal Medicines on Allergic Asthma
    Xiu Min Li; Fiscal Year: 2003
    ..Accomplishing these goals should provide an experimental basis for applying Chinese herbal medicines to the treatment of allergic asthma, and for understanding immunoregulatory mechanisms underlying their effects. ..
  8. Institute for Translational Research, Education & Experimental Therapeutics
    Hugh Sampson; Fiscal Year: 2006
    ..This Institute will provide access to breakthrough technologies and supportive resources and personnel to expedite translational research. [unreadable] [unreadable] [unreadable]..
  9. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..If soybean IT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option. ..
  10. Immunotherapy for Peanut Allergy
    ARVIL BURKS; Fiscal Year: 2007
    ..The significance of this proposal is that if peanut SLIT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option for patients. ..
  11. IMMUNOTHERAPY FOR PATIENTS WITH PEANUT ANAPHYLAXIS
    ARVIL BURKS; Fiscal Year: 2003
    ..abstract_text> ..
  12. IMMUNOMODULATION OF FOOD ALLERGY BY DNA BASED IMMUNITY
    Hugh Sampson; Fiscal Year: 2002
    ....
  13. EXTRAMURAL RES FACILITIES CONSTR PROJ
    ARVIL BURKS; Fiscal Year: 2002
    ....
  14. Immunologic Basis of Cow Milk Induced Hypersensitvities
    Hugh Sampson; Fiscal Year: 2007
    ..abstract_text> ..
  15. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005
    ..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
  16. IMMUNOBIOLOGY OF WALNUT FOOD ALLERGY
    Suzanne Teuber; Fiscal Year: 2002
    ..The above data will significantly advance our knowledge of the immunobiology of plant seed allergy. ..
  17. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  18. Tuberculosis Diagnostics: Towards More Precise Testing in Children
    Joseph Bellanti; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  20. Prevention of chronic asthma: age 7 follow up
    MARY KLINNERT; Fiscal Year: 2005
    ..In addition, we will use the early data to identify developmental precursors for poor adherence and increased asthma morbidity at age 7. ..
  21. Prognosis and Effectiveness of Advanced Lung Cancer Treatment in the Elderly
    Juan P Wisnivesky; Fiscal Year: 2010
    ..This study will provide information regarding the efficacy of several therapies and may help resolve several controversies regarding the staging and treatment of elderly patients with advanced stage lung cancer. ..
  22. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Lloyd Mayer; Fiscal Year: 2007
    ..abstract_text> ..
  23. ACRN Data Coordinating Center
    Vernon Chinchilli; Fiscal Year: 2007
    ..The DCC will develop high-quality data collection forms, MOPs, and subject handouts. The DCC will track ACRN progress, organize all meetings/conferences, and coordinate training sessions and site visits. ..
  24. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  25. Regulated expression of B. burgdorferi virulence genes
    FELIPE CARDENAS CABELLO; Fiscal Year: 2010
    ..burgdorferi. These tools will be used to identify genes that are potentially responsible for this organism's virulence and which could be targets for new vaccines and antibiotics against Lyme disease. ..
  26. PERCEPTUAL BASES OF VISUAL CONCEPTS
    EDWARD WASSERMAN; Fiscal Year: 2008
    ..The results could also promote the behavioral analysis of discrimination and generalization processes in learning-disabled or language-deficient humans. [unreadable] [unreadable]..
  27. Gastric Tube Placement in Young Children
    Marsha Ellett; Fiscal Year: 2008
    ..Results from this study will increase the safety of using gastric tubes in young children. ..
  28. Evaluating the Effectiveness of Lung Cancer Treatment in the Elderly
    Juan Wisnivesky; Fiscal Year: 2009
    ..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
  29. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  30. GROWTH OF AIRWAYS AND LUNG PARENCHYMA IN NORMAL INFANTS
    Robert Tepper; Fiscal Year: 2009
    ..abstract_text> ..
  31. PERCEPTUAL BASES OF VISUAL CONCEPTS
    Edward A Wasserman; Fiscal Year: 2010
    ..Our results should also advance our understanding of how the visual system develops and how to promote its regeneration after disease or injury. ..
  32. Role of eosinophils in intestinal epithelial dysfunction
    Glenn Furuta; Fiscal Year: 2009
    ..Long-term goals of these studies are the identification of specific diagnostic tests for EOGs and the development of novel eosinophil specific treatments. ..
  33. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  34. A Tailored Asthma Education Program for Urban Teens II
    Christine Joseph; Fiscal Year: 2009
    ..The result of this proposal will be a powerful tool for changing negative behaviors related to asthma management in a traditionally hard-to-reach population that experiences high asthma morbidity and mortality. ..
  35. Stringent response and bmp expression in B. burgdorferi
    Felipe Cabello; Fiscal Year: 2007
    ..burgdorferi from a descriptive paradigm to a paradigm framed by mechanistic and causal interpretations. ..
  36. FUNCTIONAL ROLE OF IA ON GI TRACT EPITHELIAL CELLS
    Lloyd Mayer; Fiscal Year: 2004
    ..Specific Aim #3. To further characterize the regulation of gp180 expression on intestinal epithelial cells and define a potential role for this molecule on non-IECs. ..
  37. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004
    ..The Phase II project will result in the development of consumer based allergen tests that will improve asthma management using environmental control procedures. ..
  38. Oral Tolerance: Mechanisms and Applications
    Lloyd Mayer; Fiscal Year: 2003
    ....
  39. Cancer in Older Minority Populations
    Alfred Neugut; Fiscal Year: 2003
    ..Coordination of this P20 will be facilitated by the geographic proximity of the two institutions, their scientific strengths, and their commitment to similar programs. ..
  40. Blood lead levels and development of asthma
    Christine Joseph; Fiscal Year: 2002
    ....
  41. ASTHMA CLINICAL RESEARCH NETWORK
    Vernon Chinchilli; Fiscal Year: 2002
    ....
  42. Pathogenesis of X-linked Allergic Autoimmune Diabetes
    Talal Chatila; Fiscal Year: 2002
    ..The proposed studies will provide critical insights into pathogenesis of IDDM and allergic inflammation in this group of patients and, more generally, in diseases of autoimmunity, atopy and immunodeficiency. ..
  43. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  44. EOSINOPHIL PROTEINS AND GASTROINTESTINAL DISEASE
    Glenn Furuta; Fiscal Year: 2003
    ..EDGP stimulated epithelial cell chloride ion secretion and 3. EDGP stimulated neutrophil infiltration, changes in vascular permeability and fluid secretion in vivo. ..
  45. BETA2-ADRENERGIC RECEPTOR DOWN-REGULATION IN ASTHMA
    Stacie Jones; Fiscal Year: 2004
    ..abstract_text> ..
  46. Gastrointestinal Eosinophil Research Symposium
    Glenn Furuta; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  47. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  48. Economic evaluation of naturopathy for low back pain
    Patricia Herman; Fiscal Year: 2005
    ..Hypothesis #2: A naturopathic package of care is more cost effective to the employer than usual care for the treatment of low back pain. ..
  49. Controlled Trial of an Herbal Therapy for ADHD
    Wendy Weber; Fiscal Year: 2006
    ..abstract_text> ..
  50. International Congress of Mucosal Immunology
    Lloyd Mayer; Fiscal Year: 2005
    ..Finally, it will devote major attention to mucosal vaccine development, particularly as this elucidates the search for a HIV vaccine. Overall, the Congress is a major and necessary part of the intellectual landscape of mucosal immunity. ..
  51. IMMUNOMODULATION OF VACCINIA-INDUCED ANTIMICROBIAL PEPT*
    Donald Leung; Fiscal Year: 2005
    ..abstract_text> ..
  52. IN VITRO APPROACH TO PROBLEMS OF CLINICAL ALLERGY
    David Golden; Fiscal Year: 2005
    ..We need to continue to study these patients to develop the most useful clinical guidelines. ..
  53. Genistein Exacerbation of Asthma in Mice
    Tai Guo; Fiscal Year: 2005
    ..abstract_text> ..
  54. COLORECTAL CANCER AND OTHER CANCERS OF THE GI TRACT
    Alfred Neugut; Fiscal Year: 2005
    ..abstract_text> ..
  55. MOLECULAR BASIS OF THE HYPER IGE IMMUNODEFICIENCY
    Talal Chatila; Fiscal Year: 2002
    ..These studies will provide better understanding of the pathogenesis of HIE and its allied disorders and will facilitate the design of rational therapeutic approaches. ..
  56. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..