anaphylaxis

Summary

Summary: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.

Top Publications

  1. ncbi Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
  2. ncbi Fatalities due to anaphylactic reactions to foods
    S A Bock
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    J Allergy Clin Immunol 107:191-3. 2001
  3. ncbi Further fatalities caused by anaphylactic reactions to food, 2001-2006
    S Allan Bock
    J Allergy Clin Immunol 119:1016-8. 2007
  4. doi Anaphylaxis fatalities and admissions in Australia
    Woei Kang Liew
    Department of Allergy and Immunology, Melbourne, Australia
    J Allergy Clin Immunol 123:434-42. 2009
  5. ncbi Further fatal allergic reactions to food in the United Kingdom, 1999-2006
    Richard S H Pumphrey
    J Allergy Clin Immunol 119:1018-9. 2007
  6. ncbi Helminth infection protects mice from anaphylaxis via IL-10-producing B cells
    Niamh E Mangan
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 173:6346-56. 2004
  7. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
  8. doi Anaphylaxis
    F Estelle R Simons
    Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 125:S161-81. 2010
  9. doi Epinephrine auto-injector use in adolescents at risk of anaphylaxis: a qualitative study in Scotland, UK
    M Gallagher
    Allergy and Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh, Medical School, Edinburgh, UK
    Clin Exp Allergy 41:869-77. 2011
  10. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010

Detail Information

Publications320 found, 100 shown here

  1. ncbi Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
    Hugh A Sampson
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 117:391-7. 2006
    There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis...
  2. ncbi Fatalities due to anaphylactic reactions to foods
    S A Bock
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA
    J Allergy Clin Immunol 107:191-3. 2001
    ..by the American Academy of Allergy, Asthma, and Immunology, with the assistance of the Food Allergy and Anaphylaxis Network, and for which adequate data could be collected...
  3. ncbi Further fatalities caused by anaphylactic reactions to food, 2001-2006
    S Allan Bock
    J Allergy Clin Immunol 119:1016-8. 2007
  4. doi Anaphylaxis fatalities and admissions in Australia
    Woei Kang Liew
    Department of Allergy and Immunology, Melbourne, Australia
    J Allergy Clin Immunol 123:434-42. 2009
    Detailed data on fatal anaphylaxis are limited, with national anaphylaxis fatality data for the United Kingdom and food-induced anaphylaxis fatality data for the United States. Time trends for anaphylaxis fatalities are not available.
  5. ncbi Further fatal allergic reactions to food in the United Kingdom, 1999-2006
    Richard S H Pumphrey
    J Allergy Clin Immunol 119:1018-9. 2007
  6. ncbi Helminth infection protects mice from anaphylaxis via IL-10-producing B cells
    Niamh E Mangan
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Immunol 173:6346-56. 2004
    ..infection with Schistosoma mansoni could alter the susceptibility of mice to an extreme allergic response, anaphylaxis. We formally demonstrate that S...
  7. pmc Mouse and human neutrophils induce anaphylaxis
    Friederike Jönsson
    Institut Pasteur, Unité d Allergologie Moléculaire et Cellulaire, Departement d Immunologie, Paris, France
    J Clin Invest 121:1484-96. 2011
    b>Anaphylaxis is a life-threatening hyperacute immediate hypersensitivity reaction. Classically, it depends on IgE, FcεRI, mast cells, and histamine...
  8. doi Anaphylaxis
    F Estelle R Simons
    Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 125:S161-81. 2010
    b>Anaphylaxis occurs commonly in community settings. The rate of occurrence is increasing, especially in young people...
  9. doi Epinephrine auto-injector use in adolescents at risk of anaphylaxis: a qualitative study in Scotland, UK
    M Gallagher
    Allergy and Respiratory Research Group, Centre for Population Health Sciences, The University of Edinburgh, Medical School, Edinburgh, UK
    Clin Exp Allergy 41:869-77. 2011
    ..Adolescents with severe allergies are at particular risk of severe and fatal anaphylactic reactions. Epinephrine (adrenaline) is known to be under-utilized by teenagers...
  10. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010
    ..Yet little is known of its role in human mast cell functions and in anaphylaxis. We show that S1P(2) receptors play a critical role in regulating human mast cell functions, including ..
  11. pmc Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
    Dheeraj Verma
    Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Orlando, FL 32816 2364, USA
    Proc Natl Acad Sci U S A 107:7101-6. 2010
    ..IX doses, 90-93% of F.IX-fed mice survived 12 injections without signs of allergy or anaphylaxis. Immunostaining confirmed delivery of F.IX to Peyer's patches in the ileum...
  12. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..Mice developed limited systemic manifestations of anaphylaxis, even though they developed marked intestinal mucosal mast cell degranulation...
  13. ncbi Clinical features and severity grading of anaphylaxis
    Simon G A Brown
    Department of Emergency Medicine, Royal Hobart Hospital Australia
    J Allergy Clin Immunol 114:371-6. 2004
    Existing grading systems for acute systemic hypersensitivity reactions vary considerably, have a number of deficiencies, and lack a consistent definition of anaphylaxis.
  14. doi The diagnosis and management of anaphylaxis practice parameter: 2010 update
    Phillip Lieberman
    JointCouncil of Allergy, Asthma and Immunology, 50NBrockway St, 3 3, Palatine, IL 60067, USA
    J Allergy Clin Immunol 126:477-80.e1-42. 2010
    ..The AAAAI and the ACAAI have jointly accepted responsibility for establishing "The Diagnosis and Management of Anaphylaxis Practice Parameter: 2010 Update." This is a complete and comprehensive document at the current time...
  15. doi Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy
    E Schiavi
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Allergy 66:499-508. 2011
    ..We sought to investigate the therapeutic potential of VSL#3 probiotic mixture on specific immune responses and anaphylactic reaction induced in mice by the major food allergen shrimp tropomyosin (ST)...
  16. ncbi Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
    ..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
  17. doi Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis
    Han Jung Park
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    Int Arch Allergy Immunol 157:147-50. 2012
    ..important food allergen associated with severe allergic reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and wheat-induced anaphylaxis (WIA)...
  18. pmc NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population
    A Wesley Burks
    Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatrics 128:955-65. 2011
    ..To focus on those concerns, we describe here the guidelines most pertinent to the pediatric population...
  19. pmc Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial
    H Asita de Silva
    Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    PLoS Med 8:e1000435. 2011
    ..We investigated whether adrenaline, promethazine, and hydrocortisone prevent such reactions in secondary referral hospitals in Sri Lanka by conducting a randomised, double-blind placebo-controlled trial...
  20. pmc A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
    Magali Noval Rivas
    Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Allergy Clin Immunol 131:201-12. 2013
    ..Commensal microbiota play a critical role in maintaining oral tolerance. The effect of food allergy on the gut microbial ecology remains unknown...
  21. ncbi Beekeepers anaphylaxis: successful immunotherapy covered by omalizumab
    J Schulze
    Allergy 62:963-4. 2007
  22. doi Mediators released during human anaphylaxis
    Shelley F Stone
    Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    Curr Allergy Asthma Rep 12:33-41. 2012
    A range of mediators are generated during anaphylaxis, with redundancy of effects, multiple overlapping pathways, and involvement of several cell types...
  23. ncbi The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology
    A Muraro
    Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Pediatrics, University of Padua, Padua, Italy
    Allergy 62:857-71. 2007
    b>Anaphylaxis is a growing paediatric clinical emergency that is difficult to diagnose because a consensus definition was lacking until recently. Many European countries have no specific guidelines for anaphylaxis...
  24. doi The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
    David A Mancardi
    Institut Pasteur, Departement d Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, Paris, France
    Blood 121:1563-73. 2013
    ..of IgG (FcγRs) are mandatory for the induction of various IgG-dependent models of autoimmunity, inflammation, anaphylaxis, and cancer immunotherapy...
  25. pmc Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma
    Scott P Commins
    Division of Allergy and Immunology, University of Virginia, Charlottesville, Virginia, USA
    Am J Respir Crit Care Med 185:723-30. 2012
    ..These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract...
  26. pmc Adrenaline in the treatment of anaphylaxis: what is the evidence?
    Andrew P C McLean-Tooke
    Regional Department of Immunology and Allergy, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP
    BMJ 327:1332-5. 2003
  27. pmc Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes
    Faith Huang
    Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 129:162-8.e1-3. 2012
    b>Anaphylaxis incidence is increasing.
  28. ncbi Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study
    Torkel Harboe
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
    Anesthesiology 102:897-903. 2005
    Several studies have recognized neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia, but the reported frequencies vary considerably between countries...
  29. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  30. ncbi Possible anaphylaxis after propofol in a child with food allergy
    Kristi N Hofer
    Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA 22908, USA
    Ann Pharmacother 37:398-401. 2003
    To report a case of anaphylaxis due to propofol in a child with allergies to egg and peanut oil.
  31. ncbi Epinephrine absorption in adults: intramuscular versus subcutaneous injection
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 108:871-3. 2001
    ..We recommend intramuscular injection of epinephrine into the thigh as the preferred route and site of injection of this life-saving medication in the initial treatment of anaphylaxis.
  32. ncbi Flow-assisted diagnostic management of anaphylaxis from rocuronium bromide
    D G Ebo
    Department of Immunology, Allergology and Rheumatology, University of Antwerp, Antwerp, Belgium
    Allergy 61:935-9. 2006
    Diagnosis of anaphylaxis from neuromuscular blocking agents (NMBA) is not always straightforward.
  33. pmc Altered inflammatory responses in leukotriene-deficient mice
    J L Goulet
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7020
    Proc Natl Acad Sci U S A 91:12852-6. 1994
    ..5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor...
  34. ncbi Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing?
    M Krøigaard
    Danish Anaesthesia Allergy Centre, Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Gentofte University Hospital, Copenhagen
    Br J Anaesth 95:468-71. 2005
    ....
  35. ncbi Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies
    Eiko Shimada
    Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
    Transfusion 42:766-73. 2002
    ..Haptoglobin deficiency therefore might be a risk factor for NHTRs...
  36. pmc Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis
    Yves T Falanga
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Immunol 188:4360-8. 2012
    b>Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of FcεRI-bound allergen-specific IgE...
  37. ncbi Anaphylaxis during the perioperative period
    David L Hepner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesth Analg 97:1381-95. 2003
    ..b>Anaphylaxis is the most severe immune-mediated reaction; it generally occurs on reexposure to a specific antigen and ..
  38. doi An update on epidemiology of anaphylaxis in children and adults
    Jennifer J Koplin
    Murdoch Childrens Research Institute, The University of Melbourne, Melbourne, Australia
    Curr Opin Allergy Clin Immunol 11:492-6. 2011
    ..is to describe the epidemiology of food-induced, medication-induced, drug-induced, and insect sting-induced anaphylaxis; to summarize recent changes in the incidence of anaphylaxis internationally; and to discuss recent insights ..
  39. doi Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity
    Franziska Rueff
    Department of Dermatology and Allergology, Ludwig Maximilians Universitat, Munich, Germany
    J Allergy Clin Immunol 124:1047-54. 2009
    Severe anaphylaxis to honeybee or vespid stings is associated with a variety of risk factors, which are poorly defined.
  40. doi Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
    b>Anaphylaxis is an acute, severe, and potentially fatal systemic allergic reaction...
  41. ncbi Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model
    K Shida
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Clin Exp Allergy 32:563-70. 2002
    ....
  42. doi Epidemiologic and clinical features of anaphylaxis in Korea
    Min Suk Yang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Ann Allergy Asthma Immunol 100:31-6. 2008
    Little is known about the characteristics of anaphylaxis in Korea or even in Asia.
  43. ncbi Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D
    Carlos A Camargo
    Center for D receptor Activation Research, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Allergy Clin Immunol 120:131-6. 2007
    The epidemiology of anaphylaxis is uncertain, especially its geographic distribution.
  44. ncbi Essential role for Gab2 in the allergic response
    H Gu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 412:186-90. 2001
    ..Accordingly, allergic reactions such as passive cutaneous and systemic anaphylaxis are markedly impaired in Gab2-/- mice...
  45. ncbi An enteric helminth infection protects against an allergic response to dietary antigen
    Mohamed Elfatih H Bashir
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 169:3284-92. 2002
    ..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...
  46. pmc IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 116:833-41. 2006
    ..In addition, evidence that IgG-allergen interactions can induce anaphylaxis by activating macrophages through Fc gammaRIII suggested that IgG Ab might not be able to inhibit IgE-mediated ..
  47. ncbi Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group
    Phil Lieberman
    Division of Allergy Immunology, Department of Medicine, University of Tennessee College of Medicine, Germantown, Tennessee, USA
    Ann Allergy Asthma Immunol 97:596-602. 2006
    To improve understanding of the epidemiology of anaphylaxis.
  48. ncbi Pathways of anaphylaxis in the mouse
    Richard T Strait
    Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, USA
    J Allergy Clin Immunol 109:658-68. 2002
    Although anaphylaxis is classically mediated by IgE, FcepsilonRI, mast cells, and histamine, several rodent studies suggest that an alternative pathway involving IgG, FcgammaRIII, macrophages and platelets, and platelet-activating factor ..
  49. doi Epidemiology of food allergy
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 127:594-602. 2011
    ..Recent and ongoing studies provide insights on risk factors, prevalence, and natural course that may inform clinical trials to improve diagnosis, prevention, and treatment...
  50. ncbi Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students
    Y Aihara
    Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan
    J Allergy Clin Immunol 108:1035-9. 2001
    BACKGROUND: Food-dependent, exercise-induced anaphylaxis (FEIAn) is classified among the physical allergies. The pathophysiology of FEIAn remains unknown, as does the frequency of FEIAn in the general population...
  51. pmc Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1
    Yufeng Zhou
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Nat Med 16:1128-33. 2010
    ..in the gastrointestinal lamina propria (LPDCs) for the induction of oral tolerance in a model of food-induced anaphylaxis. Oral delivery of BSA bearing 51 molecules of mannoside (Man(51)-BSA) substantially reduced the BSA-induced ..
  52. ncbi Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells
    A Mackensen
    Department of Hematology Oncology, Freiburg University Medical Center, Germany
    Cancer Immunol Immunother 49:152-6. 2000
    ..However, IgE antibodies were absent in all patients with the exception of the patient developing anaphylaxis. The patient's serum was demonstrated to contain a strong IgE response directed against BSA...
  53. ncbi Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005
    Leanne M Poulos
    Australian Centre for Asthma Monitoring, Camperdown, NSW, Australia
    J Allergy Clin Immunol 120:878-84. 2007
    ..Recent investigations in developed countries have found marked increases in the prevalence of allergic conditions...
  54. doi IgE detection to α/β/γ-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis
    S C Hofmann
    Allergy Research Group, Department of Dermatology, University Medical Center, Freiburg, Germany
    Allergy 67:1457-60. 2012
    Wheat-dependent exercise-induced anaphylaxis (WDEIA) is characterized by anaphylactic reactions after wheat ingestion and physical exercise...
  55. pmc Peri-operative anaphylaxis
    Linda Nel
    Department of Anaesthetics, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, United Kingdom
    Br J Clin Pharmacol 71:647-58. 2011
    Peri-operative anaphylaxis is an important cause for mortality and morbidity associated with anaesthesia. The true incidence is unknown and is most likely under reported...
  56. pmc Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway
    E Masini
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy
    Br J Pharmacol 137:337-44. 2002
    ..4 These findings indicate that RLX has a protective effect in cardiac anaphylaxis which involves an up-regulation of the NO biosynthetic pathway.
  57. doi Pathophysiology, diagnosis and management of exercise-induced anaphylaxis
    Paula Robson-Ansley
    Department of Sport and Exercise Science, Northumbria University, Newcastle upon Tyne, UK
    Curr Opin Allergy Clin Immunol 10:312-7. 2010
    ..the current opinions of the pathophysiological mechanisms that give rise to food dependent exercise-induced anaphylaxis (FDEIA) and to consider these mechanisms within the wider context of exercise physiology to further inform our ..
  58. ncbi Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy
    G Haeberli
    Department of Medicine, Spital Bern Ziegler, Bern, Switzerland
    Clin Exp Allergy 33:1216-20. 2003
    Mastocytosis and/or elevated basal serum tryptase may be associated with severe anaphylaxis.
  59. ncbi An open, randomized comparative trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelii russelii)
    C A Ariaratnam
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Trans R Soc Trop Med Hyg 95:74-80. 2001
    ..The safety of this larger dose is the subject of further studies...
  60. pmc Justified concern or exaggerated fear: the risk of anaphylaxis in percutaneous treatment of cystic echinococcosis-a systematic literature review
    Andreas Neumayr
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1154. 2011
    ..One of the main reasons for this reluctance is the perceived risk of anaphylaxis linked to PTs...
  61. ncbi Fast omega-gliadin is a major allergen in wheat-dependent exercise-induced anaphylaxis
    E Morita
    Department of Dermatology, Shimane Medical University, Enya cho 89 1, 693 8501, Shimane, Izumo, Japan
    J Dermatol Sci 33:99-104. 2003
    Wheat-dependent exercise-induced anaphylaxis is an anaphylaxy induced by physical exercise after ingestion of wheat...
  62. doi World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base
    F Estelle R Simons
    Departments of Pediatrics and Child Health, and Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada
    Int Arch Allergy Immunol 162:193-204. 2013
    The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis are a widely disseminated and used resource for information about anaphylaxis...
  63. ncbi Anaphylaxis: can we tell who is at risk of a fatal reaction?
    Richard Pumphrey
    Department of Immunology, St Mary s Hospital, Manchester, UK
    Curr Opin Allergy Clin Immunol 4:285-90. 2004
    b>Anaphylaxis is frightening and patients commonly fear their next reaction will be fatal. This review looks at the characteristics of fatal reactions to find if a fatal recurrence is predictable.
  64. doi Anaphylaxis caused by Hymenoptera stings: from epidemiology to treatment
    M B Bilo
    Allergy Unit, Department of Internal Medicine, Allergy, Immunology and Respiratory Diseases, University Hospital of Ancona, Ancona, Italy
    Allergy 66:35-7. 2011
    ..The prevalence of systemic reactions (SRs) is 0.3-8.9%, with anaphylaxis in 0.3-42.8% of cases...
  65. ncbi Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    X S Chen
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232
    Nature 372:179-82. 1994
    Leukotrienes constitute a class of potent biological mediators of inflammation and anaphylaxis (for reviews see refs 1 and 2)...
  66. ncbi Anaphylaxis following the ingestion of flour contaminated by house dust mites--a report of two cases from Singapore
    S Y Tay
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Asian Pac J Allergy Immunol 26:165-70. 2008
    This study presents two patients who developed anaphylaxis after eating mite-contaminated food, and also contains a survey of dust-mites contamination in flour samples from Singapore households...
  67. pmc Intestinal mast cell levels control severity of oral antigen-induced anaphylaxis in mice
    Richard Ahrens
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 180:1535-46. 2012
    Food-triggered anaphylaxis can encompass a variety of symptoms that affect multiple organ systems and can be life threatening...
  68. doi Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis
    H Matsuo
    Division of Clinical Pharmacotherapeutics, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Allergy 63:233-6. 2008
    ..that the measurement of specific IgE antibodies to B-cell epitope peptides of wheat omega-5 gliadin (Pep A) and high molecular weight glutenin subunit (Pep B) are useful to diagnose wheat-dependent exercise-induced anaphylaxis (WDEIA).
  69. ncbi Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility
    Diana Mittag
    Paul Ehrlich Institut, Langen, Germany
    Mol Nutr Food Res 48:380-9. 2004
    Baker's asthma, food allergy to wheat, and wheat-dependent, exercise-induced anaphylaxis (WDEIA) are different clinical forms of wheat allergy...
  70. pmc Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:53-8. 2009
    Intestinal anaphylaxis (manifested by acute diarrhea) is dependent on IgE and mast cells.
  71. ncbi Anaphylaxis mediated through a humanized high affinity IgE receptor
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:1645-51. 1996
    ..activated by IgE and allergens through the high affinity IgE receptor (Fc epsilon RI), play a prominent role in anaphylaxis in the mouse. Mice deficient in this receptor become resistant to passive anaphylaxis...
  72. ncbi Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis
    Melody C Carter
    J Allergy Clin Immunol 119:1550-1. 2007
  73. doi Anaphylaxis
    Marie Bénédicte De Bisschop
    Emergency Department, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Curr Opin Crit Care 18:308-17. 2012
    This article aims to make a review of the up-to-date knowledge on anaphylaxis and outline the recent advances on pathophysiology, diagnosis, and management of anaphylaxis.
  74. ncbi Platelet function in anaphylaxis
    A Kasperska-Zajac
    Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology in Zabrze, Medical University of Silesia, Poland
    J Investig Allergol Clin Immunol 16:1-4. 2006
    ..of biologically active mediators and are able to actively participate in hypersensitivity reactions, including anaphylaxis. These cells constitutively express functional receptors for the Fc fragment of IgE, both the low affinity ..
  75. ncbi Severe anaphylaxis to kiwi fruit: Immunologic changes related to successful sublingual allergen immunotherapy
    Martin Mempel
    J Allergy Clin Immunol 111:1406-9. 2003
  76. doi Anaphylaxis to cow's milk formula containing short-chain galacto-oligosaccharide
    Wen Chin Chiang
    Department of Paediatrics, KK Woman s and Children s Hospital, Singapore
    J Allergy Clin Immunol 130:1361-7. 2012
    ..On the basis of the proven prebiotic effects of oligosaccharides in cow's milk formula (CMF) in infants, CMFs are supplemented with oligosaccharides...
  77. pmc Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis
    Reem Kanjarawi
    Ciri, International Center for Infectiology Research, Mucosal immunity, Vaccination and Biotherapies Team, Universite de Lyon, Lyon, France
    PLoS ONE 8:e69183. 2013
    b>Anaphylaxis is a life-threatening outcome of immediate-type hypersensitivity to allergen, consecutive to mast cell degranulation by allergen-specific IgE...
  78. doi Pathophysiology of anaphylaxis
    Bilal Q Khan
    Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Curr Opin Allergy Clin Immunol 11:319-25. 2011
    This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis.
  79. ncbi A second dose of epinephrine for anaphylaxis: how often needed and how to carry
    John M Kelso
    J Allergy Clin Immunol 117:464-5. 2006
  80. ncbi Food-dependent exercise-induced anaphylaxis
    Eishin Morita
    Department of Dermatology, Shimane University School of Medicine, 89 1 Enya, Izumo 693 8501, Japan
    J Dermatol Sci 47:109-17. 2007
    Food-dependent exercise induced anaphylaxis (FDEIA) is a distinct form of food allergy induced by physical exercise. Symptoms are typically generalized urticaria and severe allergic reactions such as shock or hypotension...
  81. doi Symptom profile and risk factors of anaphylaxis in Central Europe
    M Worm
    Department of Dermatology and Allergy, University Hospital Charite, Berlin, Germany
    Allergy 67:691-8. 2012
    b>Anaphylaxis is the most severe manifestation of an IgE-dependent allergy. Standardized acquired clinical data from large cohorts of well-defined cases are not available...
  82. doi Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm
    Jayapal Manikandan
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cell Mol Life Sci 69:1917-29. 2012
    Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells...
  83. ncbi Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis
    Kati Palosuo
    Department of Dermatology, Hospital for Skin and Allergic Diseases, University of Helsinki, Helsinki, Finland
    J Allergy Clin Immunol 111:1386-92. 2003
    Patients with wheat-dependent, exercise-induced anaphylaxis (WDEIA) experience recurrent anaphylactic reactions when exercising after ingestion of wheat products...
  84. ncbi Anaphylaxis to gadobenate dimeglumine (Multihance): a case report
    Dimitrios C Kalogeromitros
    Allergy Unit, Attikon Hospital, University of Athens, Athens, Greece
    Int Arch Allergy Immunol 144:150-4. 2007
    ..Immediate severe adverse effects are exceptionally rare and mostly concern mild anaphylactoid reactions. We report a case of anaphylaxis to gadobenate dimeglumine (Gd-BOPTA, Multihance), a gadolinium-based contrast agent.
  85. ncbi Food-dependent exercise-induced anaphylaxis - a review of 5 cases
    Shu Lin Teo
    Department of Paediatrics, National University of Singapore, Singapore
    Ann Acad Med Singapore 38:905-9. 2009
    Food-dependent exercise-induced anaphylaxis (FDEIA) is an uncommon and under-recognised syndrome that clinicians may not consider in a patient presenting with anaphylaxis.
  86. doi Anaphylaxis to Patent Blue V. II. A unique IgE-mediated reaction
    S G O Johansson
    Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden
    Allergy 65:124-9. 2010
    ..Anaphylactic reactions, allegedly IgE antibody mediated, have been reported. The aim of the study was to explore the immunological mechanism of anaphylaxis to PBV.
  87. doi Repeat epinephrine treatments for food-related allergic reactions that present to the emergency department
    Aleena Banerji
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Allergy Asthma Proc 31:308-16. 2010
    To date, there are sparse data on epinephrine treatment for food-related anaphylaxis in adults...
  88. doi Anaphylaxis: mechanisms and management
    J K Lee
    Division of Allergy and Clinical Immunology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Clin Exp Allergy 41:923-38. 2011
    b>Anaphylaxis is a serious allergic reaction that can be rapid in onset and occasionally fatal. This is a review of the literature on the epidemiology of anaphylaxis, diagnostic criteria, mechanisms, and management...
  89. doi What are the 'ideal' features of an adrenaline (epinephrine) auto-injector in the treatment of anaphylaxis?
    A J Frew
    Department of Respiratory Medicine, Royal Sussex County Hospital, Brighton, UK
    Allergy 66:15-24. 2011
    b>Anaphylaxis is a systemic allergic reaction that often involves respiratory symptoms and cardiovascular collapse, which are potentially life-threatening if not treated promptly with intramuscular adrenaline...
  90. ncbi Comparison of international guidelines for the emergency medical management of anaphylaxis
    M Alrasbi
    Allergy and Respiratory Research Group, Division of Community Health Sciences, University of Edinburgh, Edinburgh, UK
    Allergy 62:838-41. 2007
    Guideline-based treatment approaches for managing anaphylaxis are widely believed to result in good outcomes, but the strength of evidence underpinning the recommendations made therein is unclear.
  91. ncbi Anaphylaxis in an emergency department: a 2-year study in a tertiary-care hospital
    Kanika Piromrat
    Division of Allergy and Immunology, Department of Pediatrics, Bhumibol Adulyadej Hospital, Bangkok, Thailand
    Asian Pac J Allergy Immunol 26:121-8. 2008
    The aim of this study was to estimate the incidence of anaphylaxis in the emergency department of a tertiary-care hospital, describe the clinical features and the management of the patients and determine those with mild manifestations...
  92. ncbi Anaphylaxis in adults referred to a clinical immunology/allergy centre in Singapore
    B Y H Thong
    Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Singapore Med J 46:529-34. 2005
    To study the clinical features and causes of anaphylaxis in consecutive adult patients referred to a clinical immunology/allergy centre in Singapore.
  93. doi Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice
    Katherine Arias
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 127:1552-61.e1. 2011
    Food-induced anaphylaxis is often a severe allergic reaction characterized by multiorgan dysfunction and a potentially fatal outcome.
  94. ncbi Scandinavian Clinical Practice Guidelines on the diagnosis, management and follow-up of anaphylaxis during anaesthesia
    M Kroigaard
    Danish Anaesthesia Allergy Centre, Department of Anaesthesia, Section 4231 Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Acta Anaesthesiol Scand 51:655-70. 2007
    The present approach to the diagnosis, management and follow-up of anaphylaxis during anaesthesia varies in the Scandinavian countries...
  95. ncbi Parental use of EpiPen for children with food allergies
    Jennifer S Kim
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Allergy Clin Immunol 116:164-8. 2005
    EpiPen is often underused in children with food allergy experiencing anaphylaxis.
  96. ncbi Influence of hyperosmotic conditions on basophil CD203c upregulation in patients with food-dependent exercise-induced anaphylaxis
    Anna Wolańczyk-Medrala
    Prof Wojciech Medrala, MD, Ph D, Department of Internal Medicine and Allergology, Wroclaw Medical University, Traugutta 57 59, 50 417 Wroclaw, Poland
    Ann Agric Environ Med 16:301-4. 2009
    ..basophil activation in buffers of slightly elevated osmolarity in 2 cases of food-dependent exercise-induced anaphylaxis is presented...
  97. pmc Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 123:426-33. 2009
    ..Recent work, however, has shown that IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions...
  98. ncbi Anaphylaxis due to levofloxacin
    Hideto Takahama
    Division of Dermatology, Sagamihara Kyodo Hospital, Kanagawa, Japan
    Int J Dermatol 44:789-90. 2005
  99. pmc Exercise-induced anaphylaxis: an update on diagnosis and treatment
    Wojciech Barg
    Department of Physiology, Medical University of Wroclaw, Wroclaw, Poland
    Curr Allergy Asthma Rep 11:45-51. 2011
    Exercise-induced anaphylaxis (EIA) and food-dependent, exercise-induced anaphylaxis (FDEIA) are rare but potentially life-threatening clinical syndromes in which association with exercise is crucial...
  100. ncbi Immunologic and clinical responses to parenteral immunotherapy in peanut anaphylaxis--a study using IgE and IgG4 immunoblot monitoring
    R J Bullock
    Department of Clinical Immunology and Allergy, Repatriation General Hospital, Concord, NSW 2139, Australia
    Allergol Immunopathol (Madr) 33:250-6. 2005
    Specific desensitisation to food allergens, which produce anaphylaxis after ingestion, has not been considered as a treatment for food allergy until recently...
  101. ncbi [Fatal anaphylaxis after eating wild boar meat in a patient with pork-cat syndrome]
    M Drouet
    Laboratoire d'Immuno-Allergologie-CHU-49033 Angers, France
    Allerg Immunol (Paris) 33:163-5. 2001
    ..The authors report an observation of the pork-cat syndrome (developing in the form of anaphylaxis, and then ending in the death of the patient), following consumption of wild boar meat...

Research Grants67

  1. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..marker for mast cell activation;finding activation of mast cells in the asthmatic airway and during systemic anaphylaxis;identifying two types of human mast cells (MCT and MCTC) based on the protease content of their secretory ..
  2. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..25% of the US population, are manifested as allergic asthma, rhinitis, food allergy, atopic dermatitis, and anaphylaxis. In addition to symptomatic treatments with various classical pharmaceutical agents, there are two main ..
  3. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  4. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  5. Oral immune modulatory therapy using antigens bioencapsulated in plant cells
    Roland W Herzog; Fiscal Year: 2013
    ..IX, produced by tobacco chloroplasts and bioencapsulated in plant cells, prevents formation of inhibitors and anaphylaxis in protein replacement therapy for hemophilia B (featured in PNAS 107:7101)...
  6. S. aureus and Regulatory T cells in the Failure of Oral Tolerance
    Anne Marie Singh; Fiscal Year: 2013
    ..Food allergy-induced anaphylaxis is often life threatening, and food allergy is an important risk factor for the future development of asthma ..
  7. Suppression of established IgE-mediated disease
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2013
    ..1) ingested antigen must be absorbed systemically (where it can be neutralized by IgG antibodies) to induce anaphylaxis;2) a monoclonal antibody (mAb) to the IgE binding chain of the high affinity IgE receptor, Fc5RI1, can induce ..
  8. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas A Platts-Mills; Fiscal Year: 2013
    ..Our recent investigation of a novel form of anaphylaxis identified IgE antibodies specific for the oligosaccharide galactose-[unreadable]-1,3-galactose (alpha-gal) ..
  9. Role of IL-4R-alpha signaling in food allergen sensitization and anaphylaxis
    Hans C Oettgen; Fiscal Year: 2012
    ..polymorphisms in components of IL-4/13 receptors, along with our preliminary observation of intense food anaphylaxis in mice harboring an activating variant of IL-4R[unreadable], provide support for our central hypothesis: that ..
  10. Optimizing Tolerance Induction in Peanut Allergy: The DEVIL Study
    Brian Vickery; Fiscal Year: 2013
    ..including the profound reduction in quality of life that results from an ever-present risk of life-threatening anaphylaxis Based on recent studies highlighting the potential plasticity of allergic responses early in life, and the role ..
  11. G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast Cells
    Hydar Ali; Fiscal Year: 2012
    ..Passive systemic anaphylaxis (PSA), bronchoconstriction in precision cut murine lung slices and murine model of allergic asthma will be used ..
  12. Overcoming established anaphylactic hypersensitivity to peanuts
    Kelvin P Lee; Fiscal Year: 2013
    ..Approximately 2.1% of US children are affected with peanut (PN) allergies, and PN anaphylaxis is both the primary cause of food-related deaths and accounts for 60% of all fatal/near-fatal anaphylactic ..
  13. Integrated Genomic and Functional Studies of Tolerance Therapy for Peanut Allerg
    STEPHEN JOSEPH GALLI; Fiscal Year: 2013
    ..In the U.S., ingestion of offending food allergens is the single most common cause of anaphylaxis seen in hospital emergency departments, and it is estimated that about 30,000 food-induced anaphylactic events ..
  14. HUMAN PROTEOLYTIC FOR IgA NEPHROPATHY
    Robert F Balint; Fiscal Year: 2013
    ..However, a serious drawback of the bacterial protease is its potential immunogenicity. The risks of anaphylaxis and loss of efficacy will probably be unacceptable, since large doses will likely be required to deal with the ..
  15. Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.
    Wayne G Shreffler; Fiscal Year: 2010
    ..We will also test the importance of these sugars for the induction of peanut anaphylaxis using a mouse model of peanut allergy established by my mentor (Aim III)...
  16. The role of iNKTs in eosinophilic esophagitis.
    Antonella Cianferoni; Fiscal Year: 2013
    ..provided by applicant): Pediatric FA affects 6-8% of children, in whom it is the major risk factor for anaphylaxis and eosinophilic esophagitis (EoE)...
  17. Web-based and Interactive Virtual Environments for Children with Food Allergies
    Josh S Spitalnick; Fiscal Year: 2013
    ..Food-induced anaphylaxis, which is a rapid, potentially life-threatening reaction, can occur in more serious cases...
  18. Mapping the Critical Epitopes of Ara h 2 and Ara h 6
    Stephen C Dreskin; Fiscal Year: 2013
    ..IgE-mediated reactions to foods, particularly peanuts, are the most common cause of anaphylaxis occurring outside of the hospital...
  19. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..Food allergy accounts for approximately 30,000 episodes of anaphylaxis and 100-200 deaths...
  20. PARs and S1P receptors in endothelial biology
    Shaun R Coughlin; Fiscal Year: 2013
    ..of different PARs, dramatic effects of manipulation of S1P and PAR signaling on survival in models of anaphylaxis, and long-term effects of altered barrier function in vivo...
  21. Mechanisms of Allergic Transfusion Reactions
    William Savage; Fiscal Year: 2013
    ..ATRs) manifest primarily as urticarial and pruritic reactions, but more severe reactions with angioedema and anaphylaxis can occur. The mechanisms of ATRs are not known in the vast majority of cases...
  22. Role of leukotriene B4 receptors in the interplay of inflammation and infection
    Haribabu Bodduluri; Fiscal Year: 2013
    ..are involved in the pathophysiology of many acute and chronic inflammatory diseases such as systemic anaphylaxis, asthma, atherosclerosis and arthritis...
  23. IgE to carbohydrates causes delayed anaphylaxis
    SCOTT PALMER COMMINS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal...
  24. Interaction Between the Epithelium and Mast Cells in Severe Asthma
    MERRITT LYNN FAJT; Fiscal Year: 2012
    ..Mast cells, known for their role in allergy and anaphylaxis, may lead to a deeper understanding of asthma severity but little is known regarding the levels or phenotype of ..
  25. Targeting sphingosine kinases in FceRI-mediated allergic responses
    Sarah Spiegel; Fiscal Year: 2012
    ..All have been shown to play important roles in the pathogenesis of allergic disorders, such as anaphylaxis and asthma, and their exacerbation...
  26. Regulation and functions of mast cell-derived IL-33
    Paul J Bryce; Fiscal Year: 2011
    ..critical for the recruitment of inflammatory cells into the skin during the latephase inflammatory response of anaphylaxis. Based on our preliminary data, we hypothesize that mast cells release IL-33 during activation (extrinisic ..
  27. Probiotic therapies for food allergies
    Sarkis K Mazmanian; Fiscal Year: 2011
    ..In addition to the medical and social burden of severe reactions such as anaphylaxis, the incidences of food allergies are alarmingly increasing in Western societies...
  28. Exercise, Histamine Receptors, &Vascular Health In Aging
    John R Halliwill; Fiscal Year: 2013
    ..g., asthma, allergies, anaphylaxis, and tumor growth), can play important roles in day-to-day regulation of regional blood flow related to ..
  29. Nanoparticle Enabled L-asparaginase Therapy for CLL
    SADIK ESENER; Fiscal Year: 2013
    ..limit the duration of therapy and contribute to potential side effects such as hypersensitivity reactions and anaphylaxis. Other side effects, including pancreatitis and coagulopathy, may also limit the appeal of this form of therapy ..
  30. Clinical Significance of protamine/heparin antibodies after CPB
    Gowthami M Arepally; Fiscal Year: 2012
    ..from mild symptoms (hypotension) to rare life-threatening side-effects (acute pulmonary hypertension and/or anaphylaxis)...
  31. Environmental conditions and their impact on host immunity
    Herman F Staats; Fiscal Year: 2013
    ..Food allergy causes 30,000 cases of anaphylaxis and 200 deaths annually in the United States alone...
  32. Comparative Effectiveness and Safety of Newer Agents for Anemia Treatment in HD
    WOLFGANG CHRISTOPH WINKELMAYER; Fiscal Year: 2013
    ..Events of scientific interest include short-term outcomes (anaphylaxis, laboratory parameters including hemoglobin, iron saturation, ferritin) and longer- term outcomes including ..
  33. Specific and high-resolution ultrasound cancer imaging
    Katherine W Ferrara; Fiscal Year: 2013
    ..Finally, the FDA has previously expressed concerns about complement mediated-anaphylaxis resulting from non-targeted agents but data are very limited for targeted agents...
  34. Immunological response to Chinese herbal medicine in food allergy
    Julie Wang; Fiscal Year: 2013
    ..1,2) Peanut allergy is the leading cause of food-induced anaphylaxis treated in hospital emergency departments in the United States (3) and peanut and tree nut allergies account ..
  35. Gene Responses in Basophil-Mediated Allergic Responses
    Hua Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant):The incidence and mortality of allergic diseases, such as anaphylaxis, allergic rhinitis, atopic dermatitis and asthma, have increased at an alarming rate in the Western countries in the past several ..
  36. CoFAR Statistical and Clinical Coordinating Center
    Donald M Stablein; Fiscal Year: 2013
    ..will develop new approaches to treat and prevent IgE-mediated food allergy, including food allergy-associated anaphylaxis and food allergy-associated eosinophilic gastrointestinal disease (EGID)...
  37. Targeting surface-bound IgE as a novel allergy therapeutic
    Ke Zhang; Fiscal Year: 2013
    ..We will use a systemic allergic anaphylaxis model, passive cutaneous anaphylaxis model and human basophil stimulation to test an E-3...
  38. TRIM27 is a new negative regulator of CD4 T cells and Mast cells.
    Edward Y Skolnik; Fiscal Year: 2013
    ..of TRIM27-/- mast cells are increased;(3C) the signaling pathways regulated by TRIM27 in mast cells, and/or (3D) whether TRIM27-/- mice have an increased anaphylactic response to both passive cutaneous and systemic anaphylaxis.
  39. Regulation of Food Allergy and Anaphylaxis by IL-33
    Paul J Bryce; Fiscal Year: 2013
    ..We wil examine this hypothesis using murine models of food allergy and anaphylaxis that we have developed...
  40. Role of T cells in gastrointestinal manifestations of food allergy
    MARIA CECILIA BERIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Food allergy includes both IgE-mediated disorders such as food-induced anaphylaxis and non-IgE- mediated disease such as food protein induced enterocolitis syndrome (FPIES)...
  41. Role of Phospholipase D1 in regulated exocytosis
    Michael Frohman; Fiscal Year: 2009
    ..g in diabetes) or inhibition (e.g. in anaphylaxis) of regulated exocytosis underlies numerous therapeutic modalities...
  42. Reactivation of human cells for novel fully human Ab platform
    RACHEL HANNAH KRAVITZ; Fiscal Year: 2012
    ..the strong immune responses they elicit in humans, limiting their half life in the body and potentially causing anaphylaxis. Strategies to overcome this obstacle have included humanization of rodent-derived mAbs and development of ..
  43. Immunobiology of Food Allergy and Its Treatment
    Hugh Sampson; Fiscal Year: 2013
    ..This approach is clearly inadequate since food allergic reactions are the leading single leading cause of anaphylaxis treated in US emergency departments, and dietary management of EE is extremely difficult and often ineffective...
  44. Identification Of Proteins Responsible For Peanut Allergenicity
    Fred Finkelman; Fiscal Year: 2009
    ..provided by applicant): Allergy to peanuts and tree nuts is the most common food-related cause of severe anaphylaxis and death and, unlike other food allergies, typically persists into adulthood...
  45. The Role of Stat5 in Mast Cell Activation and Inflammatory Disease
    Hoon Shim; Fiscal Year: 2012
    ..mediators of inflammation and have been studied for a number of years for their role in asthma, allergies, and anaphylaxis. However, in recent years, new data have emerged associating mast cells with a variety of other inflammatory ..
  46. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
    ..Host hypersensitivity will be gauged through passive cutaneous anaphylaxis and Schultz-Dale reactions and an in vivo "equivalent" of the Schultz-Dale reaction which involves monitoring ..
  47. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
    ..Desensitization prevents mortality from anaphylaxis during ERT in antibody-positive GAA-null mice...
  48. Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
    A Wesley Burks; Fiscal Year: 2012
    ..the most common of the food allergies occurring in 1% of young children and is the leading cause of fatal food anaphylaxis. Only 20% of young children will develop oral tolerance to peanuts by age 5 years...
  49. Preclinical Development of Uricase-PEG 20
    JOHN BOMALASKI; Fiscal Year: 2002
    ..lower plasma uric acid levels, all of the enzymes used are highly immunogenic and cause allergic reactions and anaphylaxis. Formulation of other therapeutic proteins with polyethylene glycol (PEG) has been shown to reduce their anti-..
  50. Keratinocyte Costimulation and Th2-Cell Immune Deviation
    Anthony Gaspari; Fiscal Year: 2009
    ..be studied (kinetics of IgE response, fine quantitation of low levels of lgE, passive transfer of cutaneous anaphylaxis, and studies of contact dermatitis in mast cell deficient mice)...
  51. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..If soybean IT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option. ..
  52. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..nontoxic and hypoallergenic (does not induce a significant immune response), thus avoiding "serum sickness" or anaphylaxis upon secondary use...
  53. NEURAL & PHARMACOLOGICAL CONTROL OF AIRWAY SMOOTH MUSCLE
    Richard Mitchell; Fiscal Year: 1991
    The purpose of these investigations is to determine the modulating influences of mediators of anaphylaxis on parasympathetic activation in tracheal smooth muscle...
  54. Human IgG-mediated Anaphylaxis
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2013
    ..Use of these mAbs has provided substantial benefits, but can cause development of IgG anti-mAb antibodies and anaphylaxis. Mouse and human studies suggest that anaphylaxis caused by repeated infusion of these mAbs may be mediated by ..
  55. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 1999
    ..as a precise but somewhat insensitive indication of mast cell involvement in natural and experimentally-induced anaphylaxis, asthma, rhinitis and cutaneous allergy...
  56. IMMUNOLOGIC RELEASE OF CHEMICAL MEDIATORS IN MAN
    FRANK AUSTEN; Fiscal Year: 1990
    ..Exercise-induced anaphylaxis will be addressed by a computer assisted survey and by experimentally-induced attenuated attacks to evaluate ..
  57. IN VITRO STUDIES OF THE MECHANISM OF ANAPHYLAXIS
    FRANK AUSTEN; Fiscal Year: 1999
    ....
  58. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..For example, the investigator hypothesizes that basophil-dependent anaphylaxis occurs in certain food-allergic reactions, and predict that 2D7 antigen, but not mast cell tryptase, will be ..
  59. Effect of Chinese herbal medicine on food allergy
    Xiu Min Li; Fiscal Year: 2010
    ..project, we developed Food Allergy Herbal Formula-2 (FAHF-2) and showed that it completely blocked PN-induced anaphylaxis in a murine model and had a high safety profile...
  60. Botulinum Toxin Plantibodies
    KEITH WYCOFF; Fiscal Year: 2002
    ..However, equine immune globulin has a high incidence of side effects, including serum sickness and anaphylaxis, and human immune globulin is not available in large quantities. Dr...
  61. Allergy Prevention By lgE Cytotoxic Peptide(ECP)Vaccine
    Swey Shen Chen; Fiscal Year: 2002
    ..Provided by the applicant): IgE-mediated allergic asthma, rhinitis, food allergy, atopic dermatitis, anaphylaxis cost annual 18 billions in medical costs and loss of productivity in this country...
  62. RESPIRATORY ANAPHYLAXIS TO INDUSTRIAL CHEMICALS
    MERYL KAROL; Fiscal Year: 1991
    ....
  63. Lanthanides as Novel Anti-Arthritic Agents
    Christopher Evans; Fiscal Year: 2004
    ..have been shown to reduce mortality in rats challenged by anaphylaxis, endotoxin, pancreatitis and other macrophage-dependent pathologies...
  64. BASOPHIL/MAST CELL FUNCTION
    Ann Dvorak; Fiscal Year: 2004
    ..which represents the central cellular event in acute disorders of immediate hypersensitivity, such as anaphylaxis, PMD permits the slow and/or sustained release of mediators...
  65. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2010
    ..To test this hypothesis, we plan to use two visceral hypersensitive rat models: colonic anaphylaxis (egg albumin) and colorectal irritation (acetic acid)...
  66. Genetic Determinants of Food Allergy Among Pediatric Populations
    Kathleen Barnes; Fiscal Year: 2009
    ..of substantial public health concern, affecting ~7% of the pediatric population, and is a common cause of anaphylaxis. The prevalence of food-induced anaphylaxis is rising, accounting for one-third to one-half of anaphylaxis ..
  67. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2000
    ..of tryptase immunoassays used to assess mast cell involvement in human diseases such as asthma, systemic anaphylaxis and systemic mastocytosis, the biochemical characterization of the enzyme as a heparin-stabilized tetramer ..