immediate hypersensitivity

Summary

Summary: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

Top Publications

  1. ncbi Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds
    Lise Hestbaek
    Back Research Center, Ringe, Denmark
    Spine (Phila Pa 1976) 29:1483-91; discussion 1492. 2004
  2. ncbi Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldoonado, Pichincha Provinece, Ecuador
    Am J Respir Crit Care Med 168:313-7. 2003
  3. ncbi Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients
    Javier Monteseirín
    Departamento de Medicina, Servicio Regional de Immunología y Alergia, Hospital Universitario Virgen Macarena, Sevilla, Espana
    Int Arch Allergy Immunol 131:174-81. 2003
  4. pmc The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma
    S Kruse
    University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
    Am J Hum Genet 66:1522-30. 2000
  5. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007
  6. ncbi Environmental exposure to endotoxin and its relation to asthma in school-age children
    Charlotte Braun-Fahrlander
    Institute of Social and Preventive Medicine, Basel, Switzerland
    N Engl J Med 347:869-77. 2002
  7. ncbi An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children
    T Heaton
    Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, Australia
    Lancet 365:142-9. 2005
  8. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
  9. ncbi Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
    Frank A Redegeld
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Nat Med 8:694-701. 2002
  10. ncbi Defining childhood atopic phenotypes to investigate the association of atopic sensitization with allergic disease
    R J Kurukulaaratchy
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight, UK
    Allergy 60:1280-6. 2005

Research Grants

  1. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
  2. Mast Cell-Mediated Intestinal Permeability
    Katherine Groschwitz; Fiscal Year: 2010
  3. Human Basophil Phenotypes and Therapeutic Outcomes
    Donald W Macglashan; Fiscal Year: 2013
  4. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
  5. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
  6. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
  7. IN VITRO STUDIES OF THE MECHANISM OF ANAPHYLAXIS
    FRANK AUSTEN; Fiscal Year: 1999
  8. STRUCTURE AND MECHANISM OF LIPOXYGENASE
    L Amzel; Fiscal Year: 2001
  9. IGG1 AND IGE RECEPTOR MECHANISMS IN LUNG
    Frank Graziano; Fiscal Year: 1992
  10. Immunotherapy for Peanut Allergy
    XIAOPING ZHONG; Fiscal Year: 2009

Detail Information

Publications213 found, 100 shown here

  1. ncbi Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds
    Lise Hestbaek
    Back Research Center, Ringe, Denmark
    Spine (Phila Pa 1976) 29:1483-91; discussion 1492. 2004
    ..Cross-sectional, population-based survey...
  2. ncbi Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldoonado, Pichincha Provinece, Ecuador
    Am J Respir Crit Care Med 168:313-7. 2003
    ..The results suggest that geohelminth infections do not explain the low prevalence of allergic symptoms in the study population...
  3. ncbi Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients
    Javier Monteseirín
    Departamento de Medicina, Servicio Regional de Immunología y Alergia, Hospital Universitario Virgen Macarena, Sevilla, Espana
    Int Arch Allergy Immunol 131:174-81. 2003
    ..In addition, we attempted to evaluate the relationship between neutrophil degranulation and lung function of the patients, measured as FEV(1)...
  4. pmc The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma
    S Kruse
    University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
    Am J Hum Genet 66:1522-30. 2000
    ..At the same time, they are associated with an increased risk to develop asthma and atopy. Thus, two PAFAH variants seem to play a key role in atopic and asthmatic processes in Caucasian populations...
  5. ncbi Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis
    Rob J Vandebriel
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Vaccine 25:2346-60. 2007
    ..This led us to study bacterial clearance, lung pathology, lung TNF-alpha expression, and parameters of immediate hypersensitivity (IH), being serum IgE levels, eosinophil numbers in the bronchoalveolar lavage fluid, and ex vivo IL-4, ..
  6. ncbi Environmental exposure to endotoxin and its relation to asthma in school-age children
    Charlotte Braun-Fahrlander
    Institute of Social and Preventive Medicine, Basel, Switzerland
    N Engl J Med 347:869-77. 2002
    ..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen...
  7. ncbi An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children
    T Heaton
    Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, Australia
    Lancet 365:142-9. 2005
    ..We tested this proposition in a community sample of children...
  8. pmc Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    Stephan Weidinger
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
    PLoS Genet 4:e1000166. 2008
    ..Our data furthermore confirm association of STAT6 variation with serum IgE levels...
  9. ncbi Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
    Frank A Redegeld
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Nat Med 8:694-701. 2002
    ..Although IgE and IgG(1) are central to the induction of immediate hypersensitivity reactions, our results show that IgLCs have similar activity...
  10. ncbi Defining childhood atopic phenotypes to investigate the association of atopic sensitization with allergic disease
    R J Kurukulaaratchy
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight, UK
    Allergy 60:1280-6. 2005
    ..Although atopic sensitization is common in childhood, its relationship to clinical allergic disease remains incompletely understood. We therefore sought to explore this relationship by defining sensitization based atopic phenotypes...
  11. pmc Respiratory symptoms, asthma, exercise test spirometry, and atopy in schoolchildren from a Lima shanty town
    M E Penny
    Instituto de Investigacion Nutricional, Lima, Peru
    Thorax 56:607-12. 2001
    ..The ISAAC study recently reported that the prevalence of reported asthma symptoms in Lima, Peru was among the highest in the world, but did not report on the atopic status of the subjects...
  12. ncbi Atopic sensitization and the international variation of asthma symptom prevalence in children
    Gudrun Weinmayr
    Institute of Epidemiology, Ulm University, Helmholtzstrasse 22, D 89075 Ulm, Germany
    Am J Respir Crit Care Med 176:565-74. 2007
    ..Atopic sensitization has long been known to be related to asthma in children, but its role in determining asthma prevalence remains to be elucidated further...
  13. pmc Gene-environment interaction effects on the development of immune responses in the 1st year of life
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 76:696-704. 2005
    ....
  14. ncbi Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001
    Although asthma is strongly associated with immediate hypersensitivity to indoor allergens, several studies have suggested that a cat in the house can decrease the risk of asthma...
  15. ncbi IgE-dependent release of myeloperoxidase by neutrophils from allergic patients
    J Monteseirin
    Departamento de Medicina, Servicio Regional de Inmunologia y Alergia, Hospital Universitario Virgen Macarena, Spain
    Clin Exp Allergy 31:889-92. 2001
    ..It is not known whether specific allergens are able to elicit MPO release by neutrophils from allergic patients...
  16. ncbi Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction
    T Y Shin
    College of Pharmacy, Woosuk University, Chonju, Chonbuk, Korea
    Arch Pharm Res 24:249-55. 2001
    We studied the effect of aqueous extract of Magnolia officinalis bark (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.01 to 1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in rats...
  17. ncbi Atopy may be related to exercise-induced bronchospasm in asthma
    Y I Koh
    Division of Allergy, Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Kwangju, Korea
    Clin Exp Allergy 32:532-6. 2002
    ..However, it is not clear whether atopy is related to EIB, regardless of airway hyper-responsiveness (AHR) to methacholine, because asthmatic subjects often show AHR to exercise and methacholine simultaneously...
  18. ncbi [The prevalence of respiratory symptomes and immediate hypersensitivity reactions in a population exposed to flour and cereal dust in five flour mills in Morocco]
    C H Laraqui
    Unité de Formation et de Recherche en Sécurité et Sante au Travail, Faculté des Sciences de l Education de Rabat, Rabat, France
    Int J Tuberc Lung Dis 7:382-9. 2003
    To evaluate the prevalence of respiratory symptoms, ventilatory function disorder and immediate hypersensitivity reactions in a population exposed to flour and cereal dusts in five flour mills in Morocco.
  19. ncbi Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets
    Denise C Cara
    Gastrointestinal Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 172:4964-71. 2004
    ..In this study, we examined the immediate hypersensitivity response in wild-type (WT) and mast cell-deficient mice (W/W(v)) in two different tissues (skin and ..
  20. ncbi Impact of specific sensitization on asthma and rhinitis in young Brazilian and Chilean adults
    R J Rona
    Department of Psychological Medicine, King s College London, London, UK
    Clin Exp Allergy 38:1778-86. 2008
    ..The pattern of associations and the attributable fractions (AF) of atopic conditions due to specific sensitizations vary between countries...
  21. ncbi Immediate hypersensitivity to cephalosporins
    Antonino Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Cl Columbus, I 00168 Rome, Italy
    Allergy 57:52-7. 2002
  22. ncbi Selective immediate hypersensitivity reactions to NSAIDs
    Maria Gabriela Canto
    Servicio de Alergologia, Hospital Infantal Leonor, Madrid, Spain
    Curr Opin Allergy Clin Immunol 9:293-7. 2009
    ..Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made...
  23. ncbi Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project
    J Bousquet
    Service des Maladies Respiratoires, University Hospital, Montpellier, France
    Allergy 61:671-80. 2006
    ....
  24. ncbi Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis
    Naoki Komatsu
    Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Totttori, Japan
    Invest Ophthalmol Vis Sci 49:5307-13. 2008
    ..To characterize the transcriptome of allergic conjunctivitis mediated by eosinophil-related chemokine receptor CCR3 and to identify a candidate for possible therapeutic intervention in eosinophilic inflammation of the eye...
  25. ncbi Pepsin-resistant 16-kD buckwheat protein is associated with immediate hypersensitivity reaction in patients with buckwheat allergy
    Kazuko Tanaka
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 129:49-56. 2002
    ..The ingestion of small amounts sometimes provokes an anaphylactic reaction. However, it remains controversial which is the major allergen responsible for such reactions...
  26. ncbi The inverse association between tuberculin responses and atopic disorder
    T Shirakawa
    Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Science 275:77-9. 1997
    ..Exposure and response to M. tuberculosis may, by modification of immune profiles, inhibit atopic disorder...
  27. ncbi Immediate hypersensitivity type of occupational laryngitis in a welder exposed to welding fumes of stainless steel
    Timo Hannu
    Department of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Am J Ind Med 49:402-5. 2006
    Although upper respiratory symptoms have been reported to occur in welders, occupational laryngitis of immediate hypersensitivity type due to welding fumes of stainless steel has not been previously reported.
  28. ncbi A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness
    M R Hill
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, UK
    Hum Mol Genet 5:959-62. 1996
    ..04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005)...
  29. ncbi Prolonged topical application of tacrolimus inhibits immediate hypersensitivity reactions by reducing degranulation of mast cells
    Tomoko Inoue
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Acta Derm Venereol 86:13-6. 2006
    We studied the effects of prolonged topical application of tacrolimus on immediate hypersensitivity reactions...
  30. ncbi [Skin prick test of immediate hypersensitivity in a selected Chilean pediatric population sample]
    Javiera Martinez
    Departamento de Reumatología e Inmunología Clínica, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 133:195-201. 2005
    Skin prick test (SPT) of immediate hypersensitivity is a main instrument in the diagnosis of allergy.
  31. ncbi Identification of some rabbit allergens as lipocalins
    J Baker
    Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Clin Exp Allergy 31:303-12. 2001
    ..The 18 kDa allergen from saliva may be the previously named rabbit allergen, Ory c 1...
  32. ncbi Nature of the mast cell-macrophage interaction in immediate hypersensitivity
    B A Jakschik
    Washington University School of Medicine, Department of Pharmacology, St Louis, Missouri 63110
    Adv Prostaglandin Thromboxane Leukot Res 17:180-5. 1987
    The experiments discussed above indicate that during immediate hypersensitivity reactions, macrophages are stimulated by mast cells to synthesize PGE2 and 6-keto-PGF1 alpha but not LTC4...
  33. ncbi Immediate hypersensitivity elicits renin release from cardiac mast cells
    Seiichiro Kano
    Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA
    Int Arch Allergy Immunol 146:71-5. 2008
    ..As mast cells are a primary target of hypersensitivity, we assessed whether anaphylactic mast cell degranulation also results in renin and norepinephrine release...
  34. ncbi Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood
    L C Rodrigues
    London School of Hygiene and Tropical Medicine, London, UK
    Clin Exp Allergy 38:1769-77. 2008
    ..Intestinal helminth parasites are prevalent in childhood in developing countries and are associated with a lower prevalence of allergen skin test reactivity and asthma...
  35. ncbi Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group
    K Amin
    Section of Human Anatomy, Department of Medical Cell Biology, University of Uppsala, Sweden
    Am J Respir Crit Care Med 162:2295-301. 2000
    ..This suggests that there are differences in the extent of the immunopathologic response of these clinically distinct forms of asthma...
  36. ncbi The BAMSE project: presentation of a prospective longitudinal birth cohort study
    Magnus Wickman
    Department of Environmental Health, Stockholm County Council, Stockholm, Sweden
    Pediatr Allergy Immunol 13:11-3. 2002
    ..As a separate project, financed by the EU, outdoor pollution as risk factors for asthma and allergies are to be studied within the BAMSE cohort. A follow-up of 8-9 years is underway...
  37. ncbi Exposure to birch pollen in infancy and development of atopic disease in childhood
    Anne Kihlström
    Department of Paediatrics, Huddinge Hospital, Stockholm
    J Allergy Clin Immunol 110:78-84. 2002
    ..In 1993, extremely high levels of birch pollen were recorded in Stockholm, Sweden, creating the unique opportunity to study children with different exposures during infancy...
  38. ncbi Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10
    V H van der Velden
    Department of Immunology, Erasmus University University Hospital Rotterdam, Department of Paediatrics, Sophia Children s Hospital, 3000 DR Rotterdam, The Netherlands
    Clin Exp Allergy 31:997-1006. 2001
    ..The immunological processes in early life and their relation to allergic sensitization leading to a Th2 cytokine profile are still not well understood...
  39. ncbi An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions
    Kaori Hitomi
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Nat Immunol 11:601-7. 2010
    Anaphylaxis is a life-threatening immediate hypersensitivity reaction triggered by antigen capture by immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcvarepsilonRI) on mast cells...
  40. ncbi Protein microarrays in diagnosing IgE-mediated diseases: spotting allergy at the molecular level
    Christian Harwanegg
    VBC Genomics Bioscience Research, Rennweg 95 B, 1030 Vienna, Austria
    Expert Rev Mol Diagn 4:539-48. 2004
    ....
  41. ncbi Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment
    Reinhard Hiller
    VBC GENOMICS, A 1030 Vienna, Austria
    FASEB J 16:414-6. 2002
    ..This method may change established practice in allergy diagnosis, prevention, and therapy. In addition, microarrayed antigens may be applied to the diagnosis of autoimmune and infectious diseases...
  42. ncbi Genetic variants of IL-13 signalling and human asthma and atopy
    A Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Hum Mol Genet 9:549-59. 2000
    ..38 in males, 1.10 in females) rather than asthma. Thus, certain variants of IL-13 signalling are likely to be important promoters of human asthma; detailed functional analysis of their actions is needed...
  43. ncbi Hay fever and asthma in relation to markers of infection in the United States
    Paolo Maria Matricardi
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche, Istituto Superiore di Sanita, Rome
    J Allergy Clin Immunol 110:381-7. 2002
    ..The hygiene hypothesis proposes that declining exposure to infections is implicated in the rising trend of allergy and asthma...
  44. ncbi Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma
    Pooja Takhar
    Randall Division of Cell and Molecular Biophysics, King s College London, UK
    J Allergy Clin Immunol 119:213-8. 2007
    ..It is generally believed that class switch recombination occurs in lymphoid tissue, but it was recently shown that class switching to IgE occurs in the nasal mucosa in allergic rhinitis...
  45. ncbi Immunologic influences on allergy and the TH1/TH2 balance
    Sergio Romagnani
    Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Italy
    J Allergy Clin Immunol 113:395-400. 2004
    ..The solution to this question is very important not only from a theoretic point of view but also because of its therapeutic implications...
  46. ncbi Immediate hypersensitivity reaction associated with the rapid infusion of Crotalidae polyvalent immune Fab (ovine)
    Christopher P Holstege
    Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908 0699, USA
    Ann Emerg Med 39:677-9. 2002
    ..This immediate hypersensitivity reaction was most likely a rate-related anaphylactoid reaction that has not been previously reported ..
  47. ncbi High prevalence of current asthma and active smoking effect among the elderly
    Y K Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Exp Allergy 32:1706-12. 2002
    ..Although asthma is a common cause of morbidity in adults, relatively few objectively measured population studies of asthma prevalence in adult populations have been conducted...
  48. ncbi Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases
    Ronald van Ree
    Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 129:189-97. 2002
    ..Whether their absence or presence is of importance for the application of recombinant allergens in immunotherapy is still largely unknown...
  49. ncbi Skin test antigens for immediate hypersensitivity prepared from infective larvae of Strongyloides stercoralis
    F A Neva
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 65:567-72. 2001
    ..One approach is the use of an immediate hypersensitivity skin test that would reliably identify infected people...
  50. pmc Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations
    C Ober
    Department of Human Genetics, University of Chicago, Chicago, IL 60636, USA
    Am J Hum Genet 66:517-26. 2000
    ..Overall, these data suggest that the IL4RA gene is an atopy- and asthma-susceptibility locus but that variation outside the coding region of the gene influences susceptibility...
  51. pmc The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction
    S Kruse
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Immunology 96:365-71. 1999
    ..This could explain the observed association effects with lowered total IgE concentrations...
  52. ncbi Atopic characteristics of adult patients with eosinophilic esophagitis
    Sumita Roy-Ghanta
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 6:531-5. 2008
    ..Our purpose was to identify the spectrum of specific allergic sensitivities to environmental and food allergens within a series of adult patients with EE...
  53. ncbi Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  54. ncbi The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
    G K Hershey
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 337:1720-5. 1997
    ..Atopic diseases are very common, and atopy has a strong genetic predisposition...
  55. ncbi Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Lancet 367:1598-603. 2006
    ..We investigated the effect of repeated anthelmintic treatments with albendazole over 12 months on the prevalence of atopy and clinical indices of allergy...
  56. ncbi Exhaled nitric oxide, total serum IgE and allergic sensitization in childhood asthma and allergic rhinitis
    Fabio Cardinale
    Department of Paediatrics, University of Bari, Policlinico, Bari, Italy
    Pediatr Allergy Immunol 16:236-42. 2005
    ..This finding adds further support to the hypothesis that increased serum IgE could be a marker itself of airway inflammation in patients with allergic disease...
  57. ncbi Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways
    G J Braunstahl
    Departments of Pulmonary Medicine and dagger Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
    Clin Exp Allergy 33:579-87. 2003
    ..Local airway inflammation and airway remodelling are considered important in the clinical expression of allergic asthma...
  58. ncbi Immediate hypersensitivity to rifampicin in 3 patients: diagnostic procedures and induction of clinical tolerance
    Stephan Buergin
    Department of Rheumatology, University Hospital Basel, Basel, Switzerland
    Int Arch Allergy Immunol 140:20-6. 2006
    ..Since therapy with rifampicin may be indispensable in mycobacterial infections or against multiresistant Staphylococcus aureus, desensitization may be indicated in some patients...
  59. ncbi A different pattern of risk factors for atopic and non-atopic wheezing in 9-12-year-old children
    Luis Garcia-Marcos
    Institute of Respiratory Health, University of Murcia, Spain
    Pediatr Allergy Immunol 16:471-7. 2005
    ..In summary, this study shows that atopic and current non-atopic wheezing children in Spain do not share identical environmental and family risk factors...
  60. ncbi Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  61. ncbi Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    J Allergy Clin Immunol 117:1306-13. 2006
    ..One possible explanation is that susceptibility alleles for one disease provide protection for the other...
  62. ncbi Timing of solid food introduction in relation to atopic dermatitis and atopic sensitization: results from a prospective birth cohort study
    Anne Zutavern
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Pediatrics 117:401-11. 2006
    ..This study investigates whether a delayed introduction of solids (past 4 months or 6 months) is protective against the development of atopic dermatitis (AD) and atopic sensitization when considering reverse causality...
  63. ncbi Allergen-induced cytokine secretion in atopic and non-atopic asthmatic children
    Malin F Böttcher
    Department of Molecular and Clinical Medicine, Division of Paediatrics, and Clinical Research Center, Faculty of Health Sciences, Linkoping University, Sweden
    Pediatr Allergy Immunol 14:345-50. 2003
    ..The Th2 cytokines IL-4 and IL-9 were associated only with atopic asthma, probably due to their IgE-inducing properties...
  64. ncbi Immediate hypersensitivity to quinolones: moxifloxacin cross-reactivity
    I Gonzalez
    Section of Allergy Hospital San Millán San Pedro Logroño La Rioja Spain
    J Investig Allergol Clin Immunol 15:146-9. 2005
    b>Immediate hypersensitivity reactions to quinolones are rare. Moxifloxacin is an quinolone chemically different from other fluoroquinolones...
  65. ncbi Systematic assessment of difficult-to-treat asthma
    D S Robinson
    Dept of Allergy, Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Eur Respir J 22:478-83. 2003
    ..Systematic evaluation of difficult asthma is useful as it can identify alternative or additional diagnoses, psychiatric illness or nonconcordance with therapy in a substantial proportion of cases (32% in the present series)...
  66. ncbi LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta
    James A Traherne
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
    Hum Mol Genet 12:2577-85. 2003
    ..Two regions of increased CpG concentration were identified in Fc epsilon RI-beta. One of these approximated a SNP cluster that showed strong association and maternal effects, providing a potential substrate for epigenetic effects...
  67. ncbi Immediate hypersensitivity phenomena in bullous pemphigoid: critical concepts
    Monika Bowszyc-Dmochowska
    Dermatology, Medical University of Poznan, Poznan, Poland
    J Med 33:189-98. 2002
    The immediate hypersensitivity phenomena in bullous pemphigoid (BP) will be discussed in this review. There is prominent involvement of eosinophils in the pathogenesis of human BP...
  68. ncbi Prevalence of asthma and atopy in Italian Olympic athletes
    C Maiolo
    Physiology Division, University of Tor Vergata, Rome, Italy
    Int J Sports Med 25:139-44. 2004
    ....
  69. ncbi A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases
    Masanari Hasegawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1927-33. 2003
    ..Our findings for the first time demonstrate the presence of FcepsilonRIalpha polymorphism related to the allergic diseases...
  70. ncbi Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica
    Gary M Hunninghake
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Allergy Clin Immunol 119:654-61. 2007
    ..Little is known about sensitization (defined as a positive IgE) to helminths and disease severity in patients with asthma...
  71. pmc Bioinformatics approaches to classifying allergens and predicting cross-reactivity
    Catherine H Schein
    Sealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0857, USA
    Immunol Allergy Clin North Am 27:1-27. 2007
    ..SDAP is freely available on the Web to clinicians and patients...
  72. ncbi Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins
    Antonino Romano
    Universita Cattolica del Sacro Cuore, Complesso Integrato Columbus, Rome, Italy
    Ann Intern Med 141:16-22. 2004
    ..In patients with documented IgE-mediated hypersensitivity to penicillins, data on sensitization to cephalosporins vary. Administering cephalosporins to such patients is often deferred because of the risk for cross-reactivity...
  73. ncbi Wheeze phenotypes and lung function in preschool children
    Lesley A Lowe
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 171:231-7. 2005
    ....
  74. ncbi Atopy, intestinal helminth infection and total serum IgE in rural and urban adult Gambian communities
    O A Nyan
    MRC Laboratories, Fajara, Banjul, The Gambia
    Clin Exp Allergy 31:1672-8. 2001
    ..The rarity of atopy in traditional societies has been attributed to high parasite-driven blocking IgE concentrations. Information is lacking on the relationship between atopy, IgE and intestinal helminth infection in African populations...
  75. ncbi Direct and indirect exposure to pets - risk of sensitization and asthma at 4 years in a birth cohort
    C Almqvist
    Occupational and Environmental Health, Karolinska Hospital, Stockholm, Sweden
    Clin Exp Allergy 33:1190-7. 2003
    ..There are conflicting data on the association between early exposure to pets and allergic diseases. Bias related to retrospective information on pet ownership has been addressed as a reason for distorted study results...
  76. ncbi Benzylpenicillin skin testing is still important in diagnosing immediate hypersensitivity reactions to penicillins
    A Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
    Allergy 64:249-53. 2009
    ....
  77. ncbi The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population
    L Izakovicova Holla
    Institute of Pathological Physiology, Medical Faculty, Masaryk University Brno, Czech Republic
    Clin Exp Allergy 31:1418-23. 2001
    ..These genes, inducible by interferon gamma, as well as lymphotoxin alpha (LT-alpha), are located in the HLA region. Their involvement in immune response regulation makes them candidate atopy susceptibility genes...
  78. ncbi IFN-gamma production in response to IL-18 or IL-12 stimulation by peripheral blood mononuclear cells of atopic patients
    H Shikano
    Department of Paediatrics, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Clin Exp Allergy 31:1263-70. 2001
    ..Several studies have shown that interleukin (IL)-4 and interferon-gamma (IFN-gamma) are important for the regulation of immunoglobulin E (IgE) production and that IL-18 and IL-12 induce IFN-gamma...
  79. ncbi Allergen-induced impairment of bronchoprotective nitric oxide synthesis in asthma
    F L Ricciardolo
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    J Allergy Clin Immunol 108:198-204. 2001
    ..This suggests that new therapeutic strategies towards restoring the balance among the NOS isoforms during asthma exacerbations are warranted...
  80. ncbi Increased total serum IgE levels in patients with asthma and promoter polymorphisms at CTLA4 and FCER1B
    N Hizawa
    First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan
    J Allergy Clin Immunol 108:74-9. 2001
    ..The gene encoding cytotoxic T lymphocyte antigen 4 (CTLA4) is another candidate factor in high IgE responsiveness, because B7-CD28/CTLA4 interaction can promote the differentiation and development of the T(H)2 lymphocyte subset...
  81. pmc Environmental tobacco smoke, parental atopy, and childhood asthma
    J J Jaakkola
    Environmental Health Program, The Nordic School of Public Health, Goteborg, Sweden
    Environ Health Perspect 109:579-82. 2001
    ..This phenomenon--denoted as effect modification of environmental exposure by genetic constitution, or gene by environment interaction--suggests that some genetic markers could indicate susceptibility to environmental factors...
  82. ncbi Reduced interferon-gamma production and mutations of the interleukin-12 receptor beta(2) chain gene in atopic subjects
    N Kondo
    Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan
    Int Arch Allergy Immunol 124:117-20. 2001
    ..IL-12 is a cytokine that induces IFN-gamma production. The signal of IL-12 is transduced through the IL-12 receptor (IL-12R) and Stat4...
  83. ncbi Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
    Sabine Hoffjan
    Department of Human Genetics, University of Chicago, IL 60637, USA
    J Allergy Clin Immunol 113:511-8. 2004
    ..Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma...
  84. ncbi Are biologics safe in the treatment of atopic dermatitis? A review with a focus on immediate hypersensitivity reactions
    Matthew S Bremmer
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239 4501, USA
    J Am Acad Dermatol 61:666-76. 2009
    ..Of the 261 patients with AD identified who were exposed to a biologic therapy, no type-I immediate hypersensitivity reactions were reported...
  85. ncbi Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population
    E Noguchi
    Department of Pediatrics, University of Tsukuba, Japan
    Am J Respir Crit Care Med 156:1390-3. 1997
    ..In addition, our findings suggest that loci on chromosome 5q31-q33 are linked to the development of asthma in childhood...
  86. ncbi Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
    D G Marsh
    Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD 21224
    Science 264:1152-6. 1994
    ..A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion...
  87. ncbi Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy
    D S Postma
    University Hospital, Groningen, The Netherlands
    N Engl J Med 333:894-900. 1995
    ..We attempted to define the interrelation between atopy and bronchial hyperresponsiveness and to investigate the chromosomal location of this component of asthma...
  88. ncbi The pattern of atopic sensitization is associated with the development of asthma in childhood
    S Illi
    Department of Pediatric Pneumology and Immunology, , Berlin, Germany
    J Allergy Clin Immunol 108:709-14. 2001
    ..CONCLUSION: Our results indicate that an underlying factor pertaining to asthma and maternal transmission may determine both a certain pattern of sensitization and the expression of asthma...
  89. ncbi Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor
    T Shirakawa
    Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Genet 7:125-9. 1994
    ..Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q...
  90. ncbi Associations of Fc epsilon R1-beta polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population
    M van Hage-Hamsten
    Departments of Medicine, Division of Clinical Immunology and Allergy, Karolinska Hospital, Stockholm, Sweden
    Clin Exp Allergy 32:838-42. 2002
    ..Polymorphisms within the beta subunit of the high-affinity receptor for IgE (Fc epsilon R1-beta ) on chromosome 11q13 have been related to atopy and asthma and the lymphotoxin alpha (LT alpha) gene on chromosome 6 is implicated in asthma...
  91. ncbi Additive effect of eosinophilia and atopy on exhaled nitric oxide levels in children with or without a history of respiratory symptoms
    Mario Barreto
    Paediatric Clinic, Sant Andrea Hospital, II Faculty of Medicine, University La Sapienza, Rome, Italy
    Pediatr Allergy Immunol 16:52-8. 2005
    ..6 and 2.0, p=0.009 and 0.045, respectively). Measuring eNO could be a simple, non-invasive method for identifying subjects at risk of asthma in unselected school populations...
  92. ncbi Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population
    T Shirakawa
    Osler Chest Unit, Churchill Hospital, Oxford, UK
    Hum Mol Genet 5:1129-30. 1996
    ..These results suggest that variants of Fc epsilon RI beta may be an important genetic cause of the atopic asthma...
  93. ncbi Immediate hypersensitivity to corticosteroids
    M Venturini
    Allergology Unit, Fundación Hospital de Calahorra, La Rioja, Spain
    J Investig Allergol Clin Immunol 16:51-6. 2006
    ..In comparison with the extremely frequent use of corticosteroids in different diseases, immediate allergic reactions remain uncommon. In addition to the steroid molecule, the causative agent of these reactions can be an excipient...
  94. ncbi Frequency of allergic diseases following measles
    E Kucukosmanoglu
    Department of Pediatrics, Medical Faculty, Gaziantep University Istanbul, Turkey
    Allergol Immunopathol (Madr) 34:146-9. 2006
    ..The aim of this study was to investigate the frequency of allergic diseases following measles in childhood...
  95. ncbi [Role of IgE-dependent reactions in atopic dermatitis]
    Jarosław Dynowski
    Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul Sporna 36 50, 91 738 Łódź, Poland
    Med Wieku Rozwoj 11:135-8. 2007
    ..Atopic dermatitis is a disease of multifactorial pathogenesis...
  96. ncbi [Total IgE in the sputum and serum of patients with asthma]
    G Margarit
    Hospital de la Santa Creu i de Sant Pau, Facultad de Medicina, Universitat Autonoma de Barcelona, Spain
    Allergol Immunopathol (Madr) 33:48-53. 2005
    ..The correlation between total IgE in induced sputum (IS) and serum is not well defined. The aim of this study was to investigate the relationship between total IgE in IS and total IgE in serum and airway inflammation...
  97. ncbi Air pollution and atopy
    S Boutin-Forzano
    Service de Pneumologie Allergologie, Hopital Nord, 13915 Marseille et Equipe d Accueil no 1784, Universite de la Mediterranee, Marseille
    Eur Ann Allergy Clin Immunol 37:11-6. 2005
    ..Relationship between exposure to secondhand tobacco smoke or occupational hazards and atopic sensitization have led to discordant results...
  98. ncbi House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program
    K Huss
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    J Allergy Clin Immunol 107:48-54. 2001
    ..For all allergens studied, the degree of atopy, determined by the total number of positive skin test responses or by total serum IgE levels, is an important contributing risk factor for sensitization...
  99. ncbi A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007
    ..Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy...
  100. ncbi Description of a novel panallergen of cross-reactivity between moulds and foods
    Inmaculada Herrera-Mozo
    Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Immunol Invest 35:181-97. 2006
    ..We conclude that a novel cross-reactive allergen between aeroallergens and foods has been identified...
  101. ncbi The effects of allergens in outdoor air on both atopic and nonatopic subjects with airway disease
    P G J Burney
    Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK
    Allergy 63:542-6. 2008
    ..With no generalized test for allergen in air, it is not known how far allergen is responsible for nonepidemic exacerbations of the disease...

Research Grants62

  1. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..health concerns, and mast cells and possibly basophils are the major effector cells of IgE-mediated immediate hypersensitivity in humans...
  2. Mast Cell-Mediated Intestinal Permeability
    Katherine Groschwitz; Fiscal Year: 2010
    ..provided by applicant): IgE/mast cell-mediated food allergies are serious and life-threatening immediate hypersensitivity reactions...
  3. Human Basophil Phenotypes and Therapeutic Outcomes
    Donald W Macglashan; Fiscal Year: 2013
    ..A variety of studies have implicated the basophil in the immediate hypersensitivity reactions that are part of the allergic condition...
  4. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
    ..on mouse mast cells, the knowledge and skills obtained should be directly applicable to future studies of the immunobiology and biochemistry of human mast cells, including those involved in ocular immediate hypersensitivity reactions.
  5. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ..In addition, it will be compared to the responses to Tri t I in patients with immediate hypersensitivity. These studies provide a unique opportunity to compare immune responses giving rise to DH with immune ..
  6. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    Peanut allergy is one of the most serious of the immediate hypersensitivity reactions to foods in terms of persistence and severity of the reaction and appears to be a growing problem...
  7. IN VITRO STUDIES OF THE MECHANISM OF ANAPHYLAXIS
    FRANK AUSTEN; Fiscal Year: 1999
    ..the mediators, preformed secretory granule constituents and newly derived membrane lipid metabolites, of immediate hypersensitivity reactions continue a long term commitment...
  8. STRUCTURE AND MECHANISM OF LIPOXYGENASE
    L Amzel; Fiscal Year: 2001
    ..Leukotrienes participate in host defense reactions, as well as in pathophysiological conditions such as immediate hypersensitivity, inflammation and asthma...
  9. IGG1 AND IGE RECEPTOR MECHANISMS IN LUNG
    Frank Graziano; Fiscal Year: 1992
    The guinea pig is an excellent model for studying pulmonary immediate hypersensitivity reactions. In this species, IgG1 is the major anaphylactic antibody, but IgE antibody can be produced under certain circumstances...
  10. Immunotherapy for Peanut Allergy
    XIAOPING ZHONG; Fiscal Year: 2009
    Peanut allergy is one of the most serious of the immediate hypersensitivity reactions to foods in terms of persistence and severity of reaction, and it appears to be a growing problem...
  11. CHARACTERIZATION OF DIFFERENT TYPES OF HUMAN MAST CELLS
    Lawrence Schwartz; Fiscal Year: 2009
    Mast cells are primary effector cells of immediate hypersensitivity, and may be involved in host defense, tissue homeostasis and other forms of hypersensitivity...
  12. BASOPHIL/MAST CELL FUNCTION
    Ann Dvorak; Fiscal Year: 2004
    ..to anaphylactic degranulation, which represents the central cellular event in acute disorders of immediate hypersensitivity, such as anaphylaxis, PMD permits the slow and/or sustained release of mediators...
  13. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    DESCRIPTION (Adapted from Investigator's abstract): Basophils and mast cells are major effector cells of immediate hypersensitivity reactions. In humans, mast cell involvement can be precisely identified by the presence of tryptase...
  14. Immunotherapy for Peanut Allergy
    ARVIL BURKS; Fiscal Year: 2007
    Peanut allergy is one of the most serious of the immediate hypersensitivity reactions to foods in terms of persistence and reaction severity and appears to be a growing problem without effective treatment...
  15. UV-INDUCED INHIBITION OF SMALL NUCLEAR RNA SYNTHESIS
    GEORGE ELICEIRI; Fiscal Year: 1991
    ..These are the only known genes whose expression exhibits an immediate hypersensitivity to UV radiation...
  16. STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTOR
    Michael Robertson; Fiscal Year: 1999
    ..that contribute to the clinical symptoms of many atopic disorders such as allergy, allergic asthma and immediate hypersensitivity. In this research program the structural features of Fc epsilon RI that contribute to specific receptor ..
  17. DIFFERENTIATION OF MAST CELL PROGENITORS
    Thomas Huff; Fiscal Year: 1993
    ..unique advantages to analyze mastocytogenesis, a process important in the development of diseases of immediate hypersensitivity. First, the in vitro differentiation system will be used to follow discrete changes in late-stage ..
  18. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2005
    Mast cells initiate local and systemic immediate hypersensitivity reactions, and also may influence other processes, including innate immunity, inflammation and tissue remodeling...
  19. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2000
    Mast cells initiate local and systemic immediate hypersensitivity reactions, and also may influence other processes, including innate immunity, inflammation and tissue remodeling...
  20. REDIRECTING THE IMMUNE RESPONSE TO ALLERGENS
    PAUL GUYRE; Fiscal Year: 2001
    ..the investigator's abstract) It is now clear that Th1-type cytokines can suppress IgE production and immediate hypersensitivity. Since dendritic cells (DCs) and macrophages (M s) are potent antigen presenting cells (APCs) for ..
  21. ANTIGEN PRESENTATION--MODEL OF ALLERGIC EYE DISEASE
    Gilles Benichou; Fiscal Year: 2003
    b>Immediate hypersensitivity or allergy is the most widespread immunological disorder in humans...
  22. RESPIRATORY HAZARDS OF SWINE CONFINEMENT WORKERS
    Kelley Donham; Fiscal Year: 1980
    ..are four syndromes that workers may experience: 1) chronic irritation of the upper respiratory tract; 2) immediate hypersensitivity; 3) delayed hypersensitivity; 4) acute severe, disabling respiratory symptoms...
  23. IMMUNOREGULATION OF AUTONOMIC SYNAPTIC NEUROTRANSMISSION
    Daniel Weinreich; Fiscal Year: 1993
    ..These observations should provide a valuable base for further insights into the pathophysiology of the myriad diseases associated with immediate hypersensitivity reactions.
  24. SCOR: CHRONIC DISEASES OF THE AIRWAYS
    Solbert Permutt; Fiscal Year: 1991
    ..Project III, Relationship Between Mediators of Immediate Hypersensitivity and Cellular Inflammation in the Pathophysiology of Asthma and Obstructive Airways Disease, is concerned ..
  25. Mosquito injection of Plasmodium sporozoites into skin
    Jerome Vanderberg; Fiscal Year: 2009
    ..Furthermore, the immediate hypersensitivity skin reaction to mosquito bite may modulate sporozoite migration...
  26. IGE HEAVY CHAIN CLASS SWITCHING: A MOLECULAR ANALYSIS
    CHRISTINE GRITZMACHER; Fiscal Year: 1991
    Allergic responses and immediate hypersensitivity are associated with high levels of IgE antibodies. Therefore, the study of IgE regulation is important in order to understand the basis of human allergic diseases...
  27. IN VITRO APPROACH TO PROBLEMS OF CLINICAL ALLERGY
    David Golden; Fiscal Year: 2005
    ..We need to continue to study these patients to develop the most useful clinical guidelines. ..
  28. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  29. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  30. Tuberculosis Diagnostics: Towards More Precise Testing in Children
    Joseph Bellanti; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. Virus-Induced Mechanics of Altered Airway Responsiveness
    Michael Grunstein; Fiscal Year: 2008
    ..It is anticipated that the findings from these proposed studies would yield important new insights into the mechanistic interplay between viral respiratory pathogens, atopy, and altered airway responsiveness. [unreadable] [unreadable]..
  32. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
    ..Identification of these variants may have a significant impact on the public health of asthma patients. ..
  33. SIGNAL TRANSDUCTION IN SENSITIZED AIRWAY SMOOTH MUSCLE
    Michael Grunstein; Fiscal Year: 2002
    ....
  34. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  35. Maturation of Non-Specific Airways Reactivity
    Michael Grunstein; Fiscal Year: 2007
    ....
  36. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
    ..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
  37. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  38. Early Environmental Hygiene and Pediatric Atopy
    Christine C Johnson; Fiscal Year: 2006
    ..Further, working with Dr. F. Martinez, we will use the established repository of biospecimens to develop molecular epidemiologic studies of genetic-environmental risk factors. ..
  39. Investigation of the Genetics of Asthma
    Malcolm Blumenthal; Fiscal Year: 2006
    ..This will be the first step in the identification of genes that can be used for predictive genetic analyses and development of drug targets for this common medical problem. ..
  40. COLON CANCER SURVIVORS--MEDICATIONS & RISK OF RECURRENCE
    Christine Johnson; Fiscal Year: 2004
    ..Using automated pharmacy data, the timing of use and exposure to NSAIDs and HRT will be analyzed among cancer survivors, along with potentially confounding variables, in relation to these outcomes. ..
  41. HOME BASED ENVIRONMENTAL ADHERENCE TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ....
  42. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  43. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  44. INNER CITY COCKROACH ALLERGEN REDUCTION TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ..Secondary variables, including medication use, acute care visits, school loss, FEVI and methacholine responsiveness will also be compared. ..
  45. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  46. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  47. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..
  48. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    ..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
  49. Genome-Wide Association Studies of Asthma in Populations of African Descent
    Kathleen Barnes; Fiscal Year: 2008
    ..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. [unreadable] [unreadable] [unreadable]..
  50. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  51. Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
    Adam Spanier; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Maternal Phthalate Exposure and Infertility, Fetal Loss
    Russ Hauser; Fiscal Year: 2007
    ..Since occupational and environmental exposure to phthalates is widespread, detecting even small adverse effects will have large public health significance. ..
  53. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  54. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  55. TH2-MEDIATED INFLAMMATORY RESPONSES IN THE SKIN AND LUNG
    CHRISTINA HERRICK; Fiscal Year: 2002
    ..My goal is to continue basic science investigation of atopic skin disease as a junior faculty member in the Department of Dermatology at Yale School of Medicine. ..
  56. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
    ..Insights gained from this work may lead to preventive measures which may reduce the prevalence and morbidity of childhood asthma. ..
  57. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..