allergic contact dermatitis

Summary

Summary: A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.

Top Publications

  1. ncbi Occupational dermatoses in health care workers evaluated for suspected allergic contact dermatitis
    Tina Suneja
    Department of Medicine Dermatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Contact Dermatitis 58:285-90. 2008
  2. pmc Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis
    Y Zhao
    Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Br J Dermatol 161:1301-6. 2009
  3. ncbi Effector and regulatory mechanisms in allergic contact dermatitis
    M Vocanson
    Faculté de médecine Lyon Sud, Université Lyon1, Lyon, France
    Allergy 64:1699-714. 2009
  4. ncbi Allergic contact dermatitis from propolis
    Susan E Walgrave
    University of Minnesota, School of Medicine, Minneapolis, MN, USA
    Dermatitis 16:209-15. 2005
  5. ncbi Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis
    Mark M Neis
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Germany
    J Allergy Clin Immunol 118:930-7. 2006
  6. ncbi Attenuation of allergic contact dermatitis through the endocannabinoid system
    Meliha Karsak
    Department of Molecular Psychiatry, University of Bonn, Germany
    Science 316:1494-7. 2007
  7. ncbi Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis
    Shiro Niiyama
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan
    Int Arch Allergy Immunol 153:303-14. 2010
  8. ncbi IL-23 and T(H)17-mediated inflammation in human allergic contact dermatitis
    Jeppe Madura Larsen
    Section of Experimental Immunology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    J Allergy Clin Immunol 123:486-92. 2009
  9. ncbi Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
    Xiao Ying Yuan
    Department of Dermatology, The General Hospital of the Air Force, Beijing 1000142, PR China
    Eur J Pharmacol 629:147-52. 2010
  10. ncbi Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
    E Berardesca
    Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
    Contact Dermatitis 45:280-5. 2001

Detail Information

Publications372 found, 100 shown here

  1. ncbi Occupational dermatoses in health care workers evaluated for suspected allergic contact dermatitis
    Tina Suneja
    Department of Medicine Dermatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Contact Dermatitis 58:285-90. 2008
    Occupational skin diseases, including allergic contact dermatitis (ACD), irritant contact dermatitis, and allergic contact urticaria (ACU), occur commonly among health care workers (HCWs).
  2. pmc Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis
    Y Zhao
    Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Br J Dermatol 161:1301-6. 2009
    b>Allergic contact dermatitis (ACD) is a typical delayed-type hypersensitivity to sensitizing haptens mediated by T cells. Th1/Tc1 cells are currently considered to be the primary effectors in ACD...
  3. ncbi Effector and regulatory mechanisms in allergic contact dermatitis
    M Vocanson
    Faculté de médecine Lyon Sud, Université Lyon1, Lyon, France
    Allergy 64:1699-714. 2009
    b>Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T-cell-mediated skin inflammation caused by repeated skin exposure to contact allergens, i.e. nonprotein chemicals called haptens...
  4. ncbi Allergic contact dermatitis from propolis
    Susan E Walgrave
    University of Minnesota, School of Medicine, Minneapolis, MN, USA
    Dermatitis 16:209-15. 2005
    ..Propolis is found in a number of "natural" products, including lip balms, cosmetics, lotions and ointments, shampoos, conditioners, and toothpastes. Dermatologists should consider patch testing with propolis in users of such remedies...
  5. ncbi Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis
    Mark M Neis
    Department of Dermatology and Allergology, University Hospital RWTH Aachen, Germany
    J Allergy Clin Immunol 118:930-7. 2006
    ..IL-31 is produced by activated T lymphocytes, preferentially by TH2 cells. Transgenic mice overexpressing IL-31 have a phenotype resembling allergic dermatitis in human subjects...
  6. ncbi Attenuation of allergic contact dermatitis through the endocannabinoid system
    Meliha Karsak
    Department of Molecular Psychiatry, University of Bonn, Germany
    Science 316:1494-7. 2007
    b>Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases...
  7. ncbi Th2 immune response plays a critical role in the development of nickel-induced allergic contact dermatitis
    Shiro Niiyama
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan
    Int Arch Allergy Immunol 153:303-14. 2010
    The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined...
  8. ncbi IL-23 and T(H)17-mediated inflammation in human allergic contact dermatitis
    Jeppe Madura Larsen
    Section of Experimental Immunology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    J Allergy Clin Immunol 123:486-92. 2009
    ..Recent studies have implicated T(H)17-mediated inflammation in the pathogenesis of human autoimmune diseases; however, the involvement of T(H)17 cells in allergic disorders remains largely elusive...
  9. ncbi Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
    Xiao Ying Yuan
    Department of Dermatology, The General Hospital of the Air Force, Beijing 1000142, PR China
    Eur J Pharmacol 629:147-52. 2010
    b>Allergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response...
  10. ncbi Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
    E Berardesca
    Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
    Contact Dermatitis 45:280-5. 2001
    ..g., atopic dermatitis (AD), irritant/allergic contact dermatitis (ICD, ACD)...
  11. ncbi Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity
    S Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy
    J Immunol 166:996-1002. 2001
    ....
  12. ncbi Patch test reactions in children, adults and the elderly. A comparative study in patients with suspected allergic contact dermatitis
    F Wantke
    Dermatologic and Pediatric Allergy Clinic, Vienna, Austria
    Contact Dermatitis 34:316-9. 1996
    ..n = 162), 1200 adults (20 to 50 years) and 295 elderly patients (> or = 70 years) with suspected allergic contact dermatitis using a European standard series...
  13. pmc Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis
    Philippe Azam
    Department of Medical Pharmacology and Toxicology, University of California, Davis, California 95616, USA
    J Invest Dermatol 127:1419-29. 2007
    ..We here investigated whether PAP-1, a small molecule Kv1.3 blocker (EC50=2 nM), could suppress allergic contact dermatitis (ACD)...
  14. ncbi Allergic contact dermatitis
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Int Immunopharmacol 2:201-11. 2002
    b>Allergic contact dermatitis (ACD) is a common occupational and environmental health issue...
  15. ncbi Lymphocyte transformation test in patients with allergic contact dermatitis
    Ronni Wolf
    Contact Dermatitis 53:245. 2005
  16. ncbi The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis
    Pierre Saint-Mezard
    INSERM U 404, 69007 Lyon, France
    Eur J Dermatol 14:131-8. 2004
    b>Allergic contact dermatitis (ACD) and contact hypersensitivity (CHS) are delayed-type hypersensitivity reactions which are mediated by hapten specific T cells...
  17. ncbi Afferent and efferent phases of allergic contact dermatitis (ACD) can be induced after a single skin contact with haptens: evidence using a mouse model of primary ACD
    P Saint-Mezard
    Institut National de la Santé et de la Recherche Médicale INSERM U503, 69375 Lyon Cx 07, France
    J Invest Dermatol 120:641-7. 2003
    b>Allergic contact dermatitis is a T cell-mediated delayed type hypersensitivity reaction that occurs upon hapten challenge in sensitized individuals...
  18. ncbi Allergy and skin diseases in musicians
    C Lombardi
    Allergology and Clinical Immunology Unit, Department of Internal Medicine, S Orsola Hospital, Brescia
    Eur Ann Allergy Clin Immunol 35:52-5. 2003
    ..In general, this specific allergologic problem seems to be underestimated, underdiagnosed and, as a conquence, poorly managed...
  19. ncbi Nickel elicits concomitant and correlated in vitro production of Th1-, Th2-type and regulatory cytokines in subjects with contact allergy to nickel
    J T Minang
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Scand J Immunol 62:289-96. 2005
    ..The results accentuate the importance of type 2 responses in contact allergy and also demonstrate that IL-4 and IL-13 are reliable markers for Ni2+ allergy...
  20. ncbi Allergic contact dermatitis due to aceclofenac
    G Pitarch Bort
    Department of Dermatology, Consorci Hospital General Universitari de Valencia, Avenue Tres Creus s n 46014 Valencia, Spain
    Contact Dermatitis 55:365-6. 2006
  21. ncbi Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge
    M S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    J Neuroimmunol 113:72-80. 2001
    ..These data show that acute restraint modulates cutaneous sensitization differently than challenge, but the changes are not reflected in TNF-alpha or IL-l beta production...
  22. ncbi Improved detection of allergen-specific T-cell responses in allergic contact dermatitis through the addition of 'cytokine cocktails'
    Helen Moed
    Department of Dermatology, VU University Medical Center, Amsterdam, The Netherlands
    Exp Dermatol 14:634-40. 2005
    ..The present data warrant further exploration of the application of this test to a broader set of allergens...
  23. ncbi Allergic contact dermatitis due to amorolfine nail lacquer
    Ana Fidalgo
    Dermatitis 15:54. 2004
  24. ncbi Skin contact irritation conditions the development and severity of allergic contact dermatitis
    Marlene Bonneville
    Institut National de la Sante et de la Recherche Medicale, U503, IFR128, BioSciences Lyon Gerland, Lyon, France
    J Invest Dermatol 127:1430-5. 2007
    ..b>Allergic contact dermatitis (ACD) is a frequent complication of ICD and is mediated by hapten-specific T cells primed in lymph ..
  25. ncbi Lymphocyte proliferation testing in chromium allergic contact dermatitis
    L E A M Martins
    Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Dermatol 33:472-7. 2008
    Lymphocyte proliferation testing (LPT) has some advantages over patch testing to diagnose allergic contact dermatitis. It is harmless, objective and can be used in clinical situations where patch testing is not recommended...
  26. ncbi Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis
    H El-Nour
    Unit of Dermatology and Venereology, Department of Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 28:621-31. 2006
    ..substance P and calcitonin gene-related peptide (CGRP) have been reported to be involved in allergic contact dermatitis (ACD)...
  27. ncbi Generalized allergic contact dermatitis from nitroglycerin in a transdermal therapeutic system
    Remedios Pérez-Calderón
    Department of Allergology, Infanta Cristina University Hospital Carretera de Portugal s n 06080 Badajoz Spain
    Contact Dermatitis 46:303. 2002
  28. ncbi Quality of life of patients with allergic contact dermatitis: an exploratory analysis by gender, ethnicity, age, and occupation
    Deana L Kadyk
    University of Kansas Medical Center, Kansas City, Kansas 66160 1719, USA
    Dermatitis 15:117-24. 2004
    Little has been published regarding the impact of gender, ethnicity, age, and occupation on the quality of life (QoL) of patients with allergic contact dermatitis (ACD).
  29. ncbi Allergic contact dermatitis from cocamidopropyl betaine, cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine: co-reactions or cross-reactions?
    Linda Moreau
    McGill University Health Centre, Montreal, Canada
    Dermatitis 15:146-9. 2004
    ..The presence of 3-(dimethylamino)propylamine as an impurity in all of these substances can be hypothesized to explain these simultaneous reactions...
  30. ncbi Allergic contact dermatitis
    Michael D Gober
    University of Maryland School of Medicine, Baltimore, MD 21030, USA
    Curr Dir Autoimmun 10:1-26. 2008
    b>Allergic contact dermatitis is a classic example of a cell mediated hypersensitivity reaction in the skin...
  31. ncbi Allergic contact dermatitis: novel mechanisms and therapeutic perspectives
    Andrea Cavani
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Curr Drug Metab 11:228-33. 2010
    b>Allergic contact dermatitis is a common eczematous skin disease that occurs in sensitized individuals at the site of contact with small chemicals penetrating the skin barrier...
  32. ncbi Allergic contact dermatitis from thiurams with pemphigus-like autoantibodies
    R Gallo
    Section of Dermatology Di S E M, University of Genoa, Genoa, Italy
    Contact Dermatitis 46:364-5. 2002
  33. pmc Human natural killer T cells infiltrate into the skin at elicitation sites of allergic contact dermatitis
    Michael D Gober
    Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland 21030, USA
    J Invest Dermatol 128:1460-9. 2008
    ..this study is to identify invariant natural killer T cells (NKT cells) in cellular infiltrate of human allergic contact dermatitis (ACD) skin challenge sites...
  34. ncbi Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome?
    P Hausermann
    Department of Dermatology, University Hospital Basel, CH 4031 Basel, Switzerland
    Contact Dermatitis 51:297-310. 2004
    ....
  35. ncbi Gene expression time course in the human skin during elicitation of allergic contact dermatitis
    Malene B Pedersen
    The National Allergy Research Centre for Consumer Products, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    J Invest Dermatol 127:2585-95. 2007
    Genes involved in the inflammatory response resulting in allergic contact dermatitis (ACD) are only partly known...
  36. ncbi Increased CCL27-CCR10 expression in allergic contact dermatitis: implications for local skin memory
    Heleen Moed
    Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 204:39-46. 2004
    b>Allergic contact dermatitis (ACD) is a T-cell-mediated disease in which expression of a distinct repertoire of chemokines results in the recruitment of effector T cells into the skin...
  37. ncbi Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm
    Anh Tran
    Division of Family Medicine, McMaster University, Hamilton, Ontario, Canada
    Dermatitis 21:111-5. 2010
    ..However, with the widespread use of lip balms containing peppermint oil, more cases of peppermint oil-induced ACC may be expected...
  38. ncbi Allergic contact dermatitis: the cellular effectors
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Contact Dermatitis 46:1-5. 2002
    ..subpopulations (respectively, Th1 and Th2 cells and Tc1 and Tc2 cells) in the elicitation of contact hypersensitivity reactions and consider the implications of effector cell selectivity for the biology of allergic contact dermatitis.
  39. ncbi Allergic contact dermatitis in children
    Giuseppe Militello
    University of Pennsylvania, Department of Dermatology, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 18:385-90. 2006
    The following paper reviews the recent literature pertaining to allergic contact dermatitis in the pediatric population.
  40. ncbi Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants
    Scott M Ravis
    University of Miami, USA
    J Am Dent Assoc 134:1072-8. 2003
    ..Research has found that among health care workers, dental personnel are especially likely to have reactions to glutaraldehyde and formaldehyde...
  41. ncbi The use of decision-analytical modelling in economic evaluation of patch testing in allergic contact dermatitis
    R Rajagopalan
    Glaxo Dermatology, a division of Glaxo Wellcome Inc, Research Triangle Park, North Carolina, USA
    Pharmacoeconomics 14:79-95. 1998
    ..prospective study was to demonstrate the cost effectiveness of patch testing in patients suspected of allergic contact dermatitis (ACD) and to determine the order in which different severity groups rank in terms of cost effectiveness.
  42. ncbi Occupational allergic contact dermatitis from olive oil in pizza making
    G A E Wong
    Department of Dermatology, Royal Liverpool University Hospital, Prescot St, Liverpool L7 8XP, UK
    Contact Dermatitis 50:102-3. 2004
  43. ncbi Allergic contact dermatitis from trideceth-2-carboxamide monoethanolamine (MEA) in a hair dye
    Jonathan C R Bowling
    Department of Dermatology, The Middlesex University College Hospitals, London, UK
    Contact Dermatitis 47:116-7. 2002
  44. ncbi Filaggrin null mutations and association with contact allergy and allergic contact dermatitis: results from a tertiary dermatology clinic
    Berit Christina Carlsen
    National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    Contact Dermatitis 63:89-95. 2010
    ..Filaggrin null (FLG) mutations lead to skin barrier disruption with a reduced resistance towards exogenous agents and also influence the course of disease in atopic dermatitis...
  45. ncbi Allergic contact dermatitis complicating pustular psoriasis in two patients
    R P Katugampola
    Br J Dermatol 156:788-90. 2007
  46. ncbi Allergic contact dermatitis in patients with anogenital complaints
    A Bauer
    Department of Dermatology, Friedrich Schiller University Jena, Germany
    J Reprod Med 45:649-54. 2000
    b>Allergic contact dermatitis is a common anogenital disease.
  47. ncbi Allergic contact dermatitis: pathophysiology applied to future therapy
    Lily Y Li
    Department of Dermatology, University of Texas Southwestern Medical Center and Section of Dermatology, Medical Service, Dallas Veterans Affairs Medical Center, 75390, USA
    Dermatol Ther 17:219-23. 2004
    ..The present paper reviews the pathogenesis and current treatment of allergic contact dermatitis and speculates on the prospects for improved future therapy.
  48. ncbi Interferon-gamma secreted from peripheral blood mononuclear cells as a possible diagnostic marker for allergic contact dermatitis to gold
    Jenny Christiansen
    Molecular and Immunological Pathology, IMK, Linkoping University, 581 85 Linkoping, and Department of Dermatology, University Hospital, Orebro, Sweden
    Contact Dermatitis 55:101-12. 2006
    10% of patch-tested patients have a positive reaction to gold. Most lack clinical symptoms, but allergic contact dermatitis (ACD) to gold is increasing...
  49. ncbi Topical pimecrolimus in the treatment of human allergic contact dermatitis
    David Amrol
    Vanderbilt University, Nashville, Tennessee, USA
    Ann Allergy Asthma Immunol 91:563-6. 2003
    ..Plants of the Toxicodendron species cause allergic contact dermatitis (ACD) in 50% to 70% of the population...
  50. ncbi The sex of the individual as a factor in allergic contact dermatitis
    B S Modjtahedi
    Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94143 0989, USA
    Contact Dermatitis 50:53-9. 2004
    Exogenous and endogenous factors have been implicated in allergic contact dermatitis (ACD); this review explores the sex of the individual as a possible endogenous factor...
  51. ncbi Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B
    Young Chang Cho
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Republic of Korea
    Int Immunopharmacol 10:1119-26. 2010
    ..7 macrophage cells. Using a chronic allergic contact dermatitis model induced by repeated application of oxazolone, we showed that licochalcone E inhibited the ..
  52. ncbi Allergic contact dermatitis from chlorhexidine
    Anthony T J Goon
    St John s Institute of Dermatology, London, United Kingdom
    Dermatitis 15:45-7. 2004
    Although chlorhexidine is a widely used substance, allergic contact dermatitis from chlorhexidine has rarely been reported...
  53. ncbi Vitamin E and allergic contact dermatitis
    Payman Kosari
    Center for Dermatology Research, Departments of Dermatology, Pathology, and Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Dermatitis 21:148-53. 2010
    Reports of vitamin E-induced allergic contact dermatitis (ACD) and frequent use of vitamin-E derivatives (tocopherol, tocopheryl linoleate, tocopherol acetate, etc) in skin care products deserves further investigation into tolerability ..
  54. ncbi Allergic contact dermatitis and the endocannabinoid system: from mechanisms to skin care
    Didier M Lambert
    Unite de Chimie pharmaceutique et de Radiopharmacie, Ecole de Pharmacie, Faculte de Medecine, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
    ChemMedChem 2:1701-2. 2007
  55. ncbi Allergic contact dermatitis due to benzyl alcohol in a hair dye
    J M Carrascosa
    Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
    Contact Dermatitis 55:124-5. 2006
  56. ncbi Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration
    Ilka Reines
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany
    J Invest Dermatol 129:1954-62. 2009
    ..of Langerhans cells (LCs) from the skin to the lymph node is an essential step in the pathogenesis of allergic contact dermatitis (ACD). Therefore, inhibition of LC-migration could be a promising strategy to improve this skin disease...
  57. ncbi Immunoregulation of allergic contact dermatitis
    Giampiero Girolomoni
    Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Dermatol 31:264-70. 2004
    b>Allergic contact dermatitis (ACD) to haptens can serve as a valuable paradigm for understanding the physiopathology of T cell mediated immune responses...
  58. ncbi Pyrethrum allergic contact dermatitis in humans--real?, common?, or not documented? An evidence-based approach
    Thomas G Osimitz
    Science Strategies, LLC, Charlottesville, Virginia 22902, USA
    Cutan Ocul Toxicol 25:287-308. 2006
    Pyrethrum has been reported to produce allergic contact dermatitis in humans. Moreover, it has been speculated that cross reactions occur in ragweed-sensitized people...
  59. pmc Case report: allergic contact dermatitis and new-onset asthma. Chromium exposure during leather tanning
    Leonard E Lockman
    Dakota Medical Centre, Winnipeg, Man
    Can Fam Physician 48:1907-9. 2002
  60. ncbi Rapid development of allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate
    Jeff C H Donovan
    Occupational Disease Specialty Program, James R Nethercott Occupational Health Clinic, Department of Occupational and Environmental Health, St Michael s Hospital, Ontario, Canada
    Dermatitis 20:214-7. 2009
    ..DMDI has strong sensitizing potential and requires rigorous safety monitoring in the workplace...
  61. ncbi Allergic contact dermatitis in 136 children patch tested between 2000 and 2006
    L Mark Hammonds
    Mayo Clinic, Jacksonville, FL 32224, USA
    Int J Dermatol 48:271-4. 2009
    b>Allergic contact dermatitis is often under-recognized in the pediatric population but it may affect greater than 20% of this age group.
  62. ncbi Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene
    Kristian Reich
    Department of Dermatology, Georg August University, Gottingen, Germany
    J Allergy Clin Immunol 112:1191-4. 2003
    ..chemotactic responses in CD4(+) T cells, eosinophils, and dendritic cells, plays an important role during different types of cutaneous inflammatory responses, including allergic contact dermatitis (ACD) and atopic dermatitis (AD).
  63. ncbi Allergic contact dermatitis--formation, structural requirements, and reactivity of skin sensitizers
    Ann Therese Karlberg
    Dermatochemistry and Skin Allergy and Medical Chemistry, Department of Chemistry, Gotegorg University, Goteborg, Sweden
    Chem Res Toxicol 21:53-69. 2008
    Contact allergy is caused by a wide range of chemicals after skin contact. Its clinical manifestation, allergic contact dermatitis (ACD), is developed upon repeated contact with the allergen...
  64. ncbi Allergic contact dermatitis from allyl isothiocyanate in a Danish cohort of 259 selected patients
    Anne Lerbaek
    The National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Gentofte, Denmark
    Contact Dermatitis 51:79-83. 2004
    Allyl isothiocyanate is present in many plants. Allergic contact dermatitis from allyl isothiocyanate is well known but infrequently reported...
  65. ncbi Contact vitiligo appearing after allergic contact dermatitis from aromatic reactive diluents in an epoxy resin system
    J F Silvestre
    Department of Dermatology, Hospital General de Alicante, Alicante, Spain
    Contact Dermatitis 49:113-4. 2003
  66. doi Airborne allergic contact dermatitis from 4-(bromomethyl)benzoic acid in a university chemist
    Kaija Lammintausta
    Department of Dermatology, Turku University Central Hospital, Turku, Finland
    Contact Dermatitis 58:314-5. 2008
  67. ncbi Allergic contact dermatitis to broccoli
    A Chakrabarti
    Br J Dermatol 148:172-3. 2003
  68. doi Airborne allergic contact dermatitis to methylchloroisothiazolinone/methylisothiazolinone in ironing water
    K J Hunter
    Department of Dermatology, St Mary s Hospital, Portsmouth PO3 6AD, UK
    Contact Dermatitis 58:183-4. 2008
  69. ncbi Contact allergy and allergic contact dermatitis in adolescents: prevalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS)
    Charlotte Gotthard Mortz
    Department of Dermatology, Odense University Hospital, Denmark
    Acta Derm Venereol 82:352-8. 2002
    The aims of this cross-sectional study were to establish the prevalence measures of contact allergy and allergic contact dermatitis in 8th grade schoolchildren (aged 12-16 years) in Odense, Denmark, and to examine the associations with ..
  70. pmc Early inflammatory markers in elicitation of allergic contact dermatitis
    Andrea Martin
    Dpto Bioquímica Clínica, Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Cordoba, Argentina
    BMC Dermatol 2:9. 2002
    b>Allergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction...
  71. ncbi Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis
    Beatrice Duthey
    Department of Dermatology, Clinic of the Johann Wolfgang Goethe University, Theodor Stern Kai, Frankfurt, Germany
    Exp Dermatol 19:661-6. 2010
    ..This study demonstrates a new role for the GABA(B) receptor in inflammation, making it a potential new therapeutic target to treat inflammatory skin diseases...
  72. ncbi Occupational allergic contact dermatitis from drugs in healthcare workers
    K Gielen
    Department of Dermatology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
    Contact Dermatitis 45:273-9. 2001
    ..14,689 patients suspected of contact allergy examined in our department from 1978 to 2001, occupational allergic contact dermatitis from drugs in healthcare workers was diagnosed in 33, the first in 1980...
  73. ncbi Tacrolimus modulates dendritic cell activation in the sensitization phase of allergic contact dermatitis
    H Ott
    Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany
    Skin Pharmacol Physiol 23:53-9. 2010
    Knowledge of the effect of topically applied calcineurin antagonists such as tacrolimus on the sensitization phase of allergic contact dermatitis is currently limited.
  74. ncbi Allergic contact dermatitis from a pyridine derivative in polyvinyl chloride leather
    W K Huh
    Department of Dermatology, Okayama University Medical School, Japan
    Am J Contact Dermat 12:35-7. 2001
    ..Clinicians should be aware that antifungal or antibacterial agents may be increasingly incorporated into common household products and should be suspected in cases of contact dermatitis...
  75. ncbi Erythema multiforme following allergic contact dermatitis: case report and literature review
    Katharina Wiedemeyer
    Acta Derm Venereol 87:559-61. 2007
  76. ncbi Allergic contact dermatitis from modified colophonium in wound dressings
    Teresa M Pereira
    Servico de Dermatologia e Venereologia, Hospital de São Marcos, Braga, Portugal
    Contact Dermatitis 56:5-9. 2007
    ..In patients where allergic contact dermatitis from hydrocolloid dressings is strongly suspected and colophonium tests negatively, patch testing to ..
  77. ncbi Occupational allergic contact dermatitis to silver and colophonium in a jeweler
    Sanjay Agarwal
    Royal Hallamshire Hospital, Sheffield, England
    Am J Contact Dermat 13:74. 2002
    ..Readings were taken on day 2 and day 4. Allergic positive reaction to colophonium 20% pet and silver nitrate 0.5% aq was detected. The contact sensitivities to silver and colophonium seem to be occupationally relevant in this case...
  78. ncbi Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis
    Silvia Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 118:1052-8. 2002
    Development of allergic contact dermatitis to haptens depends upon a balance between CD8(+) T lymphocytes with pathogenic activity and CD4(+) T cells, which comprise both effector and regulatory cells...
  79. ncbi Allergic contact dermatitis from cosmetics. Retrospective analysis of 819 patch-tested patients
    L Kohl
    Department of Dermatology, University Hospital St Pierre, Brussels, Belgium
    Dermatology 204:334-7. 2002
    ..Cosmetics have been used since the oldest known civilisations, and nowadays almost everybody resorts to beauty products...
  80. ncbi [Allergic contact dermatitis to the Comfeel hydrocolloid dressing]
    A Grange-Prunier
    Service de Dermatologie, Hopital Pasteur, 39, avenue de la Liberté, 68024 Colmar Cedex
    Ann Dermatol Venereol 129:725-7. 2002
    b>Allergic contact dermatitis is frequent in patients with chronic leg ulcers. However, it rarely occurs with modern wound dressings and is exceptional with hydrocolloids.
  81. ncbi Allergic contact dermatitis from EMLA cream in a hemodialyzed patient
    Lidia Comba Pérez-Pérez
    Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain
    Dermatitis 17:85-7. 2006
    ..Patch testing elicited a positive reaction to several allergens, including EMLA cream "as is" and prilocaine. The lesions resolved after topical treatment with corticosteroids...
  82. ncbi Does allergic contact dermatitis from formaldehyde in clothes treated with durable-press chemical finishes exist in the USA?
    Anton C de Groot
    Schipslootweg 5, 8351 HV Wapserveen, The Netherlands
    Contact Dermatitis 62:127-36. 2010
    Recent US studies have presented case series of patient with allergic contact dermatitis (ACD) allegedly caused by formaldehyde in clothes treated with durable-press chemical finishes (DPCF), which are known formaldehyde releasers...
  83. ncbi Allergic contact dermatitis to mango flesh
    Sari Weinstein
    Department of Dermatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Int J Dermatol 43:195-6. 2004
    ..The clinical relevance of nickel and p-tertbutylphenol formaldehyde resin was thought to be associated with the wrist lesion immediately below a glued portion of a wristwatch strap and metal clasp...
  84. ncbi Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol
    R Gallo
    Section of Dermatology Di S E M University of Genoa, Viale Benedetto XV 7, 16132 Genoa, Italy
    Contact Dermatitis 48:176-7. 2003
  85. ncbi Allergic contact dermatitis due to benzalkonium chloride in plaster of Paris
    D A Wong
    Department of Dermatology, Royal Newcastle Hospital, Newcastle, New South Wales, Australia
    Australas J Dermatol 42:33-5. 2001
    ..b>Allergic contact dermatitis caused by POP has been reported only rarely in the medical literature...
  86. ncbi Allergic contact dermatitis to copolymers in cosmetics--case report and review of the literature
    Sarah Quartier
    Department of Dermatology, University Hospital, Catholic University Leuven, B 3000 Leuven, Belgium
    Contact Dermatitis 55:257-67. 2006
    ..They have been underestimated for a long time as to their sensitizing capacities. Allergic contact dermatitis to 6 copolymers in cosmetics and 1 in a medical dressing has been described; however, the nature of the ..
  87. ncbi Allergic contact dermatitis because of topical use of 5-fluorouracil (Efudix cream)
    B U G A Meijer
    Department of Dermatology and Venereology, Erasmus MC, Rotterdam, The Netherlands
    Contact Dermatitis 57:58-60. 2007
  88. doi Allergic contact dermatitis to iodopropynyl butylcarbamate found in a cosmetic cleansing wipe
    Janakan Natkunarajah
    Department of Dermatology, St Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA, UK
    Contact Dermatitis 58:316-7. 2008
  89. ncbi Allergic contact dermatitis to idebenone used as an antioxidant in an anti-wrinkle cream
    Denis Sasseville
    Division of Dermatology, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A IAI, Canada
    Contact Dermatitis 56:117-8. 2007
  90. ncbi Classification of contact allergens according to potency: proposals
    I Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Food Chem Toxicol 41:1799-809. 2003
    ..what is known of potency and thresholds in the induction of skin sensitisation and the elicitation of allergic contact dermatitis, and to identify approaches that might be available for assessment of relative potency for the purposes ..
  91. ncbi [Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil)]
    T M Fritz
    Dermatologische Klinik, , Suisse
    Ann Dermatol Venereol 128:123-6. 2001
    ..RESULTS: We report on 7 cases of patients with an allergic contact dermatitis due to tea tree oil...
  92. ncbi Acute stress modulates the irritant component of sensitizers in allergic contact dermatitis: implications for exposure assessment
    Melanie S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 188:50-8. 2003
    Exposure of skin to noxious environmental stimuli can cause allergic contact dermatitis (ACD), which is a major health risk...
  93. ncbi Allergic contact dermatitis from Laurus nobilis oil induced by massage
    Esra Adisen
    Department of Dermatology, Gazi University, 06500 Besevler, Ankara, Turkey
    Contact Dermatitis 56:360-1. 2007
    ..Herein, we report a case of allergic contact dermatitis after a massage with a mixture of olive oil and L. nobilis oil...
  94. ncbi Cytokine expression profiles during murine contact allergy: T helper 2 cytokines are expressed irrespective of the type of contact allergen
    P Ulrich
    PCS Genetic and Experimental Toxicology, Novartis Pharma AG, Basel, Switzerland
    Arch Toxicol 75:470-9. 2001
    ..The results are expected to renew the discussion about the usefulness of the Th1/Th2 paradigm in certain areas of immunotoxicology...
  95. ncbi Allergic contact dermatitis due to methyl salicylate in a compress
    Naoki Oiso
    Department of Dermatology, Saiseikai Tondabayashi Hospital, 1 3 36 Koyodai, Tondabayashi, Osaka 584 0082, Japan
    Contact Dermatitis 51:34-5. 2004
  96. ncbi Histamine H(4) receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge
    M Seike
    Department of Food and Nutrition Science, Sagami Women s Junior College, Bunkyo, Sagamihara, Kanagawa, Japan
    Allergy 65:319-26. 2010
    The present study observed effects of the histamine H(4) receptor on chronic allergic contact dermatitis induced by repeated challenge in mice.
  97. ncbi Flexural allergic contact dermatitis to benzalkonium chloride in antiseptic bath oil
    S Hann
    Department of Occupational Dermatology, Royal Gwent Hospital, Newport, U K
    Br J Dermatol 157:795-8. 2007
    Benzalkonium chloride (BAK) is an acknowledged irritant but has also been identified as a cause of allergic contact dermatitis. The antiseptic bath emollient Oilatum Plus (Stiefel, High Wycombe, U.K...
  98. ncbi Allergic contact dermatitis to propolis in a violin maker
    Heather D Lieberman
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    J Am Acad Dermatol 46:S30-1. 2002
    Allergy to colophony is well noted in the literature, however, there have been few case reports of allergic contact dermatitis to propolis in musicians and instrument makers...
  99. ncbi 'Dermatologically tested' baby toilet tissues: a cause of allergic contact dermatitis in adults
    An Timmermans
    Department of Dermatology, University Hospital, K U Leuven, B 3000 Leuven, Belgium
    Contact Dermatitis 57:97-9. 2007
    We describe 4 adults with an allergic contact dermatitis for moist baby toilet tissues, being used either for their personal hygiene or for their babies (children)...
  100. ncbi Allergic contact dermatitis to a sanitary pad
    Marius Rademaker
    Dermatology Department, Waikato Hospital, Hamilton, New Zealand
    Australas J Dermatol 45:234-5. 2004
    ..During patch testing she also developed reactions to a black permanent waterproof marking pen used to mark the site of patch tests. The ink of this pen also contained colophony...
  101. ncbi Acetylator phenotype in Iraqi patients with allergic contact dermatitis
    Rafid A Najim
    University of Baghdad, Department of Pharmacology, College of Medicine, Iraq
    Ann Saudi Med 25:473-6. 2005
    Few studies have been done on acetylator status in ACD. This study determined acetylator status in Iraqi patients with allergic contact dermatitis (ACD) in comparison to a matched control group.

Research Grants40

  1. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..This will be accomplished by utilizing well-defined murine models of cutaneous inflammation such as allergic contact dermatitis, irritant contact dermatitis and acute photodermatitis...
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..irritation and injury, acute systemic toxicity, dermal absorption, dermal corrosivity and irritation, allergic contact dermatitis, pyrogenicity, and vaccine potency...
  3. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..irritation and injury, acute systemic toxicity, dermal absorption, dermal corrosivity and irritation, allergic contact dermatitis, pyrogenicity, and vaccine potency...
  4. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..Based on the fact that the small molecule Kv1.3 blocker PAP-1 also effectively suppresses allergic contact dermatitis (ACD) in rats when administered orally or topically, we now intend to explore the role of Kv1...
  5. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..a large number of industrial and environmental chemicals for their potentials to cause irritant and allergic contact dermatitis. Once developed and validated, the resulting 3D skin model may enable the industry to eliminate the use ..
  6. Keratinocyte regulation of skin immunity
    Anthony A Gaspari; Fiscal Year: 2013
    ..We will utilize both human and mouse models of the common skin condition, allergic contact dermatitis (ACD). We selected this skin condition because it is a common skin disease in Veterans...
  7. Regulation of TSLP-Mediated Skin Inflammation
    Steven F Ziegler; Fiscal Year: 2013
    ..vulgaris, as well as allergic responses that lead to acute and chronic atopic dermatitis (AD) and allergic contact dermatitis (ACD)...
  8. StrataScreenSENS, Skin Sensitizer Detection in Luminescent 3D Human Skin Models
    Cathy Rasmussen; Fiscal Year: 2012
    ..b>Allergic contact dermatitis (ACD) is a wide- spread public health problem resulting from exposure of human skin to certain reactive ..
  9. Peripheral Neural Mechanisms of Inflammatory Itch and Pain
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..applicant): The peripheral mechanisms of inflammatory itch and pain will be studied in a mouse model of allergic contact dermatitis (ACD) in humans...
  10. Keratinocyte Costimulation and Th2-Cell Immune Deviation
    Anthony Gaspari; Fiscal Year: 2009
    ..keratinocytes can contribute to the development of a skewed immune response to haptens that cause allergic contact dermatitis, promoting the emergence of Th2-1ymphocytes under circumstances when this type of Th-lymphocyte subset ..
  11. Novel Topical Treatment of Eczema
    Bakul Bhatt; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents 1 of the 4 most common occupationally related diseases, accounting for substantial ..
  12. MOLECULAR BASIS OF T CELL HOMING TO INFLAMED SKIN
    Louis Picker; Fiscal Year: 1999
    ..T cells, and thus may participate in the pathogenesis of chronic inflammatory skin diseases, such as allergic contact dermatitis (ACD), atopic dermatitis (AD)...
  13. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    ..This is in contrast to allergic contact dermatitis (ACD), in which hapten specific CD4+ T-lymphocytes are thought to be critical in the immunopathogenesis ..
  14. QUANTIFICATION OF SKIN ACRYLATE ADDUCTS
    Leena Nylander French; Fiscal Year: 2000
    ..Investigator's Abstract) Multifunctional acrylate are potent contact sensitizers and, thus, may cause allergic contact dermatitis and may promote skin cancer...
  15. GENETIC FINGERPRINTS OF IRRITANT CONTACT DERMATITIS
    Paul Bergstresser; Fiscal Year: 2000
    ..Recent studies demonstrate that although irritant contact dermatitis and its companion disease, allergic contact dermatitis, have different origins (specific immunologic recognition versus non-specific inflammation), their ..
  16. IMMUNOMODULATION OF CUTANEOUS ENDOTHELIAL CELLS BY A-MSH
    Cheryl Armstrong; Fiscal Year: 1999
    ..of inflammation generated in three distinct murine models of common cutaneous inflammatory diseases: allergic contact dermatitis, irritant dermatitis, and acute photodermatitis in wild type and genetically altered animals...
  17. Novel Skin Barrier to Prevent and Treat Poison Ivy
    Charles Gauntt; Fiscal Year: 2004
    Poison ivy/oak dermatitis (also known as Toxicodendron dermatitis) is the most common allergic contact dermatitis in the United States, affecting millions of Americans every year...
  18. MECHANISMS OF CYTOSKELETAL INJURY BY NI COMPOUNDS
    Ken Lin; Fiscal Year: 1990
    ..of industries, is a well documented carcinogen as well as a potent skin sensitizer causing severe allergic contact dermatitis. Thus, the causal role of Ni compounds as occupational hazards is significant...
  19. T-CELL MECHANISMS OF PATHOLOGY IN DTH & DRUG ERUPTIONS
    Richard Kalish; Fiscal Year: 1992
    The goal of this project is to determine the mechanisms of lymphocyte mediated cutaneous pathology in allergic contact dermatitis to urushiol (Toxicodendron radicans, "poison ivy") and in drug eruptions...
  20. Experimental and Clinical Contact Dermatitis Meetings
    Kevin Cooper; Fiscal Year: 2002
    ..provide a forum for North American scientists and physicians to discuss issues concerning irritant and allergic contact dermatitis. The first meeting was held in Cincinnati in May 1999 and the second in Dallas in Nov. 2000...
  21. International Symposium on Atopic Dermatitis
    Jon Hanifin; Fiscal Year: 2001
    ..of atopic disease on the prevalence, incidence, and costs of occupational dermatoses, specifically allergic contact dermatitis/hand eczema; 6) Improve the public awareness regarding the scope and prevalence of AD and the range of ..
  22. In Vitro Assay For Chemical Allergens
    Seyoum Ayehunie; Fiscal Year: 2009
    b>Allergic contact dermatitis (ACD) is one of the most common and costly health problems in industrialized countries...
  23. NEURO MICROVASCULAR MECHANISMS IN SKIN INFLAMMATION
    JOHN ANSEL; Fiscal Year: 2001
    ..Third is to determine the role of DMEC-mediated neurogenic inflammation in the pathogenesis of animal models of allergic contact dermatitis, irritant dermatitis, and acute photodermatitis.
  24. In Vitro Assay For Chemical Allergens
    Seyoum Ayehunie; Fiscal Year: 2004
    b>Allergic contact dermatitis (ACD) is one of the most common and costly health problems in industrialized countries...
  25. REGULATION OF THE IMMUNE RESPONSE TO CONTACT ALLERGENS
    Henry Maguire; Fiscal Year: 1980
    The flare reaction in allergic contact dermatitis is an activation (inflammation) of old ACD challenge sites when the allergen is given parenterally...
  26. UV-induced Immunosuppression to chemical toxicants
    Kevin Cooper; Fiscal Year: 2006
    ..Thus, an allergic contact dermatitis (ACD) skin reaction to a chemical environmental agent alone can be converted into an immune suppressed ..
  27. ALLERGIC CONTACT DERMATITIS: MECHANISMS OF ELICITATION
    Hui Xu; Fiscal Year: 2008
    b>Allergic contact dermatitis is a T-cell mediated cutaneous inflammatory disease caused by epicutaneous exposure to reactive haptens...
  28. THE ROLE OF IL-17 PRODUCING T LYMPHOCYTES IN ALLERGIC CONTACT DERMATITIS
    Hui Xu; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Allergic contact dermatitis (ACD) is a T cell mediated cutaneous inflammatory disease caused by epicutaneous exposure to reactive allergens...
  29. Mechanism for maternal transfer of asthma risk
    Robert Lim; Fiscal Year: 2007
    ..Third, dendritic cell gene expression patterns between these two groups will be compared using gene arrays ..
  30. PATIENT ORIENTED RESEARCH IN CUTANEOUS ONCOLOGY
    Stuart Lessin; Fiscal Year: 2003
    ..Lessin to continue to participate in the ongoing departmental and institutional POR programs and serve as a role model and mentor for young investigators in POR at the University of Pennsylvania. ..
  31. Reconstruction of skin model containing Langerhans cells
    Seyoum Ayehunie; Fiscal Year: 2003
    ..2 cytokines known to be critically involved in the initial stages of allergic contact dermatitis (ACD). Exposure to the common irritant, on the other hand, did not result in TNF-a or IL- lb release...
  32. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
    ..Furthermore, studies of inhibition of HO-1 and IL-10 will be carried out to determine functional association of 15d-PGJ2 with HO-1 and IL-10. ..
  33. In Vitro Tissue Model of Psoriasis
    Seyoum Ayehunie; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  34. Immortized Human Langerhans Cells
    Seyoum Ayehunie; Fiscal Year: 2002
    ..into a highly differentiated skin model and the capacity of such an immuno-competent model to predict allergic contact dermatitis will be studied...
  35. Validation of a Human In Vitro Vaginal Irritation Test
    Seyoum Ayehunie; Fiscal Year: 2007
    ..The proposed human tissue based assay will provide a sensitive and specific time-efficient method to screen a large number of chemicals/formulations at a reduced cost. [unreadable] [unreadable] [unreadable]..
  36. Validation of Organotypic Vaginal Tissue Based Assay for Endocrine Disruptors
    Seyoum Ayehunie; Fiscal Year: 2007
    ..The proposed human organotypic tissue based assay will provide a sensitive and specific assay method to screen a large number of endocrine disrupting chemicals at a reduced cost. [unreadable] [unreadable] [unreadable]..
  37. Generation and Analysis of Langerhans Cell Null Mice
    Daniel Kaplan; Fiscal Year: 2008
    ..This proposed 5 year mentored program will allow me to develop a unique model system that will provide the basis for many long term projects and collaborations and further my development into an independent investigator. ..
  38. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
  39. Outcomes of Omission of Radiation With Lumpectomy (BCS) Among Low-Income Women
    Roger Anderson; Fiscal Year: 2007
    ..abstract_text> ..
  40. CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVO
    Salvador Gonzalez; Fiscal Year: 2002
    ..of this work is to establish new criteria to differentiate acute Irritant Contact Dermatitis (ICD) from Allergic Contact Dermatitis (ACD) by using a video rate (real-time), near-infrared confocal reflectance microscope (CM)...