delayed hypersensitivity

Summary

Summary: An increased reactivity to specific antigens mediated not by antibodies but by cells.

Top Publications

  1. pmc Human allograft acceptance is associated with immune regulation
    A M VanBuskirk
    Department of Surgery, Ohio State University, Columbus, Ohio, USA
    J Clin Invest 106:145-55. 2000
  2. ncbi Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome
    I Jolanda M de Vries
    Department of Tumor Immunology, Radbond University Nijmegen Medical Center, Geert Grooteplein 26 28, 6500 HB Nijmegen, Netherlands
    J Clin Oncol 23:5779-87. 2005
  3. ncbi Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea
    S Georgala
    National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece
    J Eur Acad Dermatol Venereol 15:441-4. 2001
  4. ncbi Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression
    J D Geiger
    Department of Surgery, Section of Pediatric Surgery, Section of General Surgery, the Tumor Immunology and Immunotherapy Program, Ann Arbor, Michigan 48109 0245, USA
    Cancer Res 61:8513-9. 2001
  5. ncbi Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
    M K Gjertsen
    Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Int J Cancer 92:441-50. 2001
  6. ncbi A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer
    Alfred E Chang
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
    Clin Cancer Res 8:1021-32. 2002
  7. ncbi Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
  8. ncbi Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
    Andrea A Itano
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Immunity 19:47-57. 2003
  9. pmc Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice
    P H Hart
    Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia 5001
    J Exp Med 187:2045-53. 1998
  10. ncbi Evaluation of delayed hypersensitivity: from PPD to poison ivy
    D L Rosenstreich
    Division of Allergy Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    Allergy Proc 14:395-400. 1993

Detail Information

Publications228 found, 100 shown here

  1. pmc Human allograft acceptance is associated with immune regulation
    A M VanBuskirk
    Department of Surgery, Ohio State University, Columbus, Ohio, USA
    J Clin Invest 106:145-55. 2000
    ..This demonstrates that allograft acceptance in humans is associated with an immune regulation pattern, which may be useful in the diagnosis and/or monitoring of transplant patients for allograft acceptance...
  2. ncbi Immunomonitoring tumor-specific T cells in delayed-type hypersensitivity skin biopsies after dendritic cell vaccination correlates with clinical outcome
    I Jolanda M de Vries
    Department of Tumor Immunology, Radbond University Nijmegen Medical Center, Geert Grooteplein 26 28, 6500 HB Nijmegen, Netherlands
    J Clin Oncol 23:5779-87. 2005
    ..In this study, we investigated the predictive value of the presence or absence of antigen-specific T cells in biopsies from delayed-type hypersensitivity (DTH) sites...
  3. ncbi Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea
    S Georgala
    National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece
    J Eur Acad Dermatol Venereol 15:441-4. 2001
    ..Immunohistochemical findings suggest that a delayed hypersensitivity reaction, possibly triggered by antigens of follicular origin, probably related to D...
  4. ncbi Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression
    J D Geiger
    Department of Surgery, Section of Pediatric Surgery, Section of General Surgery, the Tumor Immunology and Immunotherapy Program, Ann Arbor, Michigan 48109 0245, USA
    Cancer Res 61:8513-9. 2001
    ..Most importantly, we have demonstrated the ability of the tumor lysate/KLH-pulsed DC to generate specific T-cell responses and to elicit regression of metastatic disease...
  5. ncbi Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
    M K Gjertsen
    Section for Immunotherapy, Department of Immunology, Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Int J Cancer 92:441-50. 2001
    ....
  6. ncbi A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer
    Alfred E Chang
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109 0932, USA
    Clin Cancer Res 8:1021-32. 2002
    ..The objectives of this study were to assess the toxicity and immunological response induced by the intradermal (i.d) administration of tumor lysate-pulsed dendritic cells (DCs)...
  7. ncbi Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
    ..To determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects...
  8. ncbi Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
    Andrea A Itano
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Immunity 19:47-57. 2003
    ..Therefore, presentation of peptide:MHC II complexes derived from a subcutaneous antigen occurs in two temporally distinct waves with different functional consequences...
  9. pmc Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice
    P H Hart
    Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia 5001
    J Exp Med 187:2045-53. 1998
    ....
  10. ncbi Evaluation of delayed hypersensitivity: from PPD to poison ivy
    D L Rosenstreich
    Division of Allergy Immunology, Albert Einstein College of Medicine, Bronx, New York 10461
    Allergy Proc 14:395-400. 1993
    ..The presence of functional CMI can be easily tested in vivo by delayed hypersensitivity (DTH) skin testing...
  11. pmc Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial
    R Yamanaka
    Department of Neurosurgery, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata City, 951 8585, Japan
    Br J Cancer 89:1172-9. 2003
    ..This study demonstrated the safety and antitumour effects of autologous tumour lysate-pulsed dendritic cell therapy for patients with malignant glioma...
  12. ncbi Leishmania major: species specific delayed hypersensitivity reaction induced by exogenous secreted antigen in the guinea pig
    A R Khabiri
    Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran
    Exp Parasitol 112:184-6. 2006
    ....
  13. ncbi Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center St Radboud Nijmegen and Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 9:5091-100. 2003
    ..We have investigated the capacity of immature and mature monocyte-derived DCs pulsed with melanoma-associated peptides (gp100 and tyrosinase) to induce a primary cytotoxic T-lymphocyte response in vivo...
  14. ncbi Unexpectedly high incidence of persistent itching nodules and delayed hypersensitivity to aluminium in children after the use of adsorbed vaccines from a single manufacturer
    Elisabet Bergfors
    Department of Primary Health Care, Goteborg University, Box 454, S 40530 Göteborg, Sweden
    Vaccine 22:64-9. 2003
    ..g. vaccines and antiperspirants). The reason for the high incidence of itching nodules after SSI vaccines is unknown and should be further investigated...
  15. ncbi Lymphocyte proliferation response in patients with delayed hypersensitivity reactions to heparins
    S Lopez
    Research Laboratory, Carlos Haya Hospital Fundacion IMABIS, 29009 Malaga, Spain
    Br J Dermatol 160:259-65. 2009
    ..Heparins can induce delayed-type hypersensitivity (DTH) reactions mediated by specific T lymphocytes. However, the interaction between heparins and lymphocytes has not been sufficiently studied...
  16. ncbi Characterization of a Listeria monocytogenes-specific protein capable of inducing delayed hypersensitivity in Listeria-immune mice
    S Gohmann
    Institut für Genetik und Mikrobiologie der Universität, Wurzburg, FRG
    Mol Microbiol 4:1091-9. 1990
    ..The ImaA gene was unique to the pathogenic species L. monocytogenes and Listeria ivanovii; it was not present in any other species of the genus Listeria...
  17. ncbi From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library
    Fabiano Oliveira
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, 12735 Twinbrook Parkway, Room 2E 22C, Rockville, Maryland 20852, USA
    Vaccine 24:374-90. 2006
    ..This approach can help to identify DTH inducing proteins that may be related to host protection against vector-borne diseases or other disease agents where cellular immune response is protective...
  18. ncbi Delayed hypersensitivity to tuberculin, total immunoglobulin E, specific sensitization, and atopic manifestation in longitudinally followed early Bacille Calmette-Guérin-vaccinated and nonvaccinated children
    C Gruber
    Children s Hospital, Charite Campus Virchow, Medical Faculty of Humboldt Universität, Berlin, Germany
    Pediatrics 107:E36. 2001
    ..Bacille Calmette-Guérin (BCG) is a strong T helper 1 incentive and, thus, may contribute to a decreased risk of T helper 2-dependent atopic disease...
  19. ncbi Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
    Rainer Kunstfeld
    Cutaneous Biology Research Center, Massachusetts General Hospital, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Blood 104:1048-57. 2004
    ..They also indicate that inhibition of VEGF-A bioactivity might be a new approach to anti-inflammatory therapy...
  20. pmc Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
    T Biedermann
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, 80337 Munich, Germany
    J Exp Med 192:1441-52. 2000
    ..Thus, mast cell-derived TNF and MIP-2 ultimately determine the pattern of infiltrating cells during T cell-mediated DTHRs...
  21. ncbi The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model
    Jinbo Fang
    School of Life Sciences, Northeast Normal University, 5268 Renmin Street, Nanguan District, Changchun 130024, PR China
    Vaccine 23:4860-6. 2005
    ..Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy...
  22. ncbi Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity
    Regis B Gomes
    Centro de Pesquisa Gonçalo Moniz, Fundacao Oswaldo Cruz, and Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Infect Dis 186:1530-4. 2002
    ..chagasi cell-mediated immunity supports the hypothesis that induction of immune response against SGS can facilitate induction of a protective response against leishmaniasis...
  23. ncbi Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests
    W J Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences and Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Oncol 17:974-80. 2006
    ..Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients...
  24. ncbi Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation
    Hossam M Ashour
    Immunology Graduate Program, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 176:5950-7. 2006
    ..These results suggest that peripheral tolerance induced through the eye requires Ag-presenting B cells that simultaneously present Ags on both MHC class I and II molecules...
  25. pmc The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma
    Robert E Cone
    Department of Immunology, The University of Connecticut Health Center, Farmington, CT 06030 3105, USA
    Immunology 120:112-9. 2007
    ..Ultimately, we demonstrated that the generation of these CD8(+) regulatory T cells occurred independently of IFN-gamma, but their suppressor function required IFN-gamma receptor stimulation...
  26. ncbi Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
    ..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
  27. ncbi Delayed hypersensitivity to piperacillin
    A Romano
    Department of Internal Medicine and Geriatrics, UCSC Allergy Unit C I Columbus Rome, Italy
    Allergy 57:459. 2002
  28. pmc The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses
    Lawrence Y Lee
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030 7552, USA
    J Clin Invest 110:1461-71. 2002
    ..These data suggest a role for Map as an immunomodulatory protein that may play a role in persistent SA infections by affecting protective cellular immunity...
  29. pmc Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan
    Selma M B Jeronimo
    Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil
    J Infect Dis 196:1261-9. 2007
    ..chagasi may identify proteins essential for immune protection against this parasitic disease and reveal strategies for immunotherapy or prevention...
  30. ncbi Parthenium dermatitis caused by immediate and delayed hypersensitivity
    Chembolli Lakshmi
    Contact Dermatitis 57:64-5. 2007
  31. ncbi Cimetidine prevents suppression of delayed hypersensitivity in an animal model of haemorrhagic shock
    Peter MacD Hewitt
    Department of Surgery, Cancer Research Laboratories, University of New South Wales and St George Hospital, NSW 2217, Sydney, Australia
    Injury 33:673-8. 2002
    ..Cimetidine reverses immunosuppression following trauma, however, its effect on pure haemorrhagic shock is unknown...
  32. ncbi Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation
    Molly E Skelsey
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 44:5242-51. 2003
    ..To characterize the role of B cells in the induction of anterior chamber-associated immune deviation (ACAID)...
  33. ncbi CD4+PD-1+ T cells acting as regulatory cells during the induction of anterior chamber-associated immune deviation
    Qianli Meng
    Zhongshan Ophthalmic Center, Uveitis Study Center, Sun Yat Sen University, Key Laboratory of Ophthalmology, Ministry of Education, Guangzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 47:4444-52. 2006
    ..To study the expression and functional characteristics of programmed death-1 (PD-1) and its ligands in the spleens of mice undergoing anterior chamber-associated immune deviation (ACAID)...
  34. ncbi The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation
    J M Rivas
    Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
    J Leukoc Biol 56:769-75. 1994
    ..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
  35. ncbi Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice
    S J Galli
    Science 226:710-3. 1984
    It has been suggested that reserpine blocks expression of delayed hypersensitivity in mice because it depletes stores of the vasoactive amine serotonin in mast cells...
  36. ncbi Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response
    P L Chisholm
    Biogen, Inc, Cambridge Center, MA 02142
    Eur J Immunol 23:682-8. 1993
    ..These data are consistent with a central role for VLA-4 in the pathophysiologic process of inflammation...
  37. ncbi Implication for the CD94/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells
    Subhasis Chattopadhyay
    Department of Immunology, Connecticut Lions Vascular Eye Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Int Immunol 20:509-16. 2008
    ....
  38. doi Delayed hypersensitivity to acylureidopenicillins: a case report
    F Gaeta
    Unità di Allergologia, Complesso Integrato Columbus, Via G Moscati, 3100168 Rome, Italy
    Allergy 63:787-9. 2008
  39. pmc Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients
    A Escobar
    Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Clin Exp Immunol 142:555-68. 2005
    ..It is safe and causes no significant side effects and has been demonstrated to be partially efficient at triggering effective anti-melanoma immunity...
  40. ncbi In situ detection of antigen-specific T cells in cryo-sections using MHC class I tetramers after dendritic cell vaccination of melanoma patients
    I J M de Vries
    Department of Tumor Immunology, Medical Oncology and Pediatric Hemato Oncology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cancer Immunol Immunother 56:1667-76. 2007
    ....
  41. ncbi Blood mononuclear cells induce regulatory NK T thymocytes in anterior chamber-associated immune deviation
    Y Wang
    Department of Pathology and Vision Immunology Center, University of Connecticut Health Center, Farmington, USA
    J Leukoc Biol 69:741-6. 2001
    ....
  42. ncbi Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation
    Xuan Chen
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    Immunol Lett 107:140-7. 2006
    ..Our study reveal that IDO is up-regulated during ACAID and IDO inhibitor prevents ACAID generation, suggesting that IDO is involved in the development of this immune tolerance...
  43. ncbi Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation
    E M Jaffee
    Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 19:145-56. 2001
    ..To determine its safety and ability to induce antitumor immune responses, we conducted a phase I trial in patients with surgically resected adenocarcinoma of the pancreas...
  44. pmc Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
    Jeong Hyeon Sohn
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky, USA
    Nat Med 9:206-12. 2003
    ..These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance...
  45. pmc Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model
    Anja W Olsen
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Infect Immun 72:6148-50. 2004
    ..The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model...
  46. pmc CD25+, interleukin-10-producing CD4+ T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye
    Molly E Skelsey
    Graduate Program in Immunology, University of Texas South Western Medical Center, Dallas, TX 75390 9057, USA
    Immunology 110:18-29. 2003
    ..Finally, the CD4+ afferent T suppressor cells are not natural killer T cells, but do express the CD25 cell surface marker...
  47. ncbi Th1/Th2-balance in anterior chamber-associated immune deviation by alloantigen
    Rieko Sakai
    Department of Ophthalmology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Graefes Arch Clin Exp Ophthalmol 240:154-9. 2002
    ..Inoculated Ag induces the generation of T cells that down-regulate delayed-type hypersensitivity (DTH). The induction mechanism may well involve various cytokines...
  48. ncbi Enhanced humoral immune response correlates with improved disease-free and overall survival in American Joint Committee on Cancer stage II melanoma patients receiving adjuvant polyvalent vaccine
    L Andrew Difronzo
    Sonya Valley Ghidossi Vaccine Laboratory, Roy E Coats Research Laboratories, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Oncol 20:3242-8. 2002
    ..Specific immune responses to tumor-associated antigens might correlate with disease-free survival (DFS) and OS in patients receiving adjuvant PV therapy for primary melanoma...
  49. pmc Increased expression of Foxp3 in splenic CD8+ T cells from mice with anterior chamber-associated immune deviation
    Liqiong Jiang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Uveitis Study Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 13:968-74. 2007
    ..To examine the expression of Foxp3 on CD8+ T cells in the spleen during anterior chamber-associated immune deviation (ACAID)...
  50. ncbi Genistein as an anti-inflammatory agent
    M Verdrengh
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Inflamm Res 52:341-6. 2003
    ..The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice...
  51. ncbi Cationic supported lipid bilayers for antigen presentation
    N Lincopan
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, Av Lineu Prestes 748 Butantã, CEP 05513 970, Sao Paulo, SP, Brazil
    Int J Pharm 340:216-22. 2007
    ..Cationic bilayer-covered particles are a novel, highly organized and, possibly, general immunoadjuvant for antigen presentation and subunit vaccine design...
  52. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  53. ncbi Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine
    M L Disis
    Division of Oncology, University of Washington, Seattle 98195 6527, USA
    Clin Cancer Res 5:1289-97. 1999
    ..The use of peptide-based vaccines may be a simple, yet effective, vaccine strategy for immunizing humans to oncogenic self-proteins...
  54. pmc Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection
    S M B Jeronimo
    Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil
    Genes Immun 8:539-51. 2007
    ..00; P=0.042; 95% CI=1.04-8.65). These results indicate several genes in the immune response gene cluster at 5q23.3-q31.1 influence outcomes of L. chagasi infection in this region of Brazil...
  55. ncbi Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis
    T K Tarrant
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20892, USA
    J Immunol 161:122-7. 1998
    ..b>Delayed hypersensitivity to IRBP was marginally reduced, whereas Ag-specific proliferation was enhanced...
  56. ncbi Treatment of multiple sclerosis with the pregnancy hormone estriol
    Nancy L Sicotte
    Department of Neurology, Reed Neurological Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 52:421-8. 2002
    ..This novel treatment strategy of using pregnancy doses of estriol in multiple sclerosis has relevance to other autoimmune diseases that also improve during pregnancy...
  57. ncbi A case of recurrent sterile abscesses following vaccination: delayed hypersensitivity to aluminum
    Heather K Lehman
    Division of Allergy Immunology, University of Buffalo School of Medicine and Biomedical Sciences, Women and Children s Hospital of Buffalo, Buffalo, NY 14222, USA
    J Pediatr 152:133-5. 2008
  58. pmc CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site
    K H Sonoda
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Exp Med 190:1215-26. 1999
    ..A critical role for NKT cells in the development of systemic tolerance associated with an immune-privileged site suggests a mechanism involving NKT cells in self-tolerance and their defects in autoimmunity...
  59. ncbi Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant tolerance
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:392-9. 2007
    ..Here we tested the hypothesis that the assay can reveal control of allograft rejection by CD25CD4 regulatory T cells (Treg)...
  60. ncbi Delayed-type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization
    M L Disis
    Division of Oncology, University of Washington, Seattle 98195, USA
    Clin Cancer Res 6:1347-50. 2000
    ....
  61. ncbi Mechanisms of graft acceptance: evidence that plasminogen activator controls donor-reactive delayed-type hypersensitivity responses in cardiac allograft acceptor mice
    A A Bickerstaff
    Department of Surgery, Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA
    J Immunol 164:5132-9. 2000
    ....
  62. ncbi Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin
    N D Staite
    Pharmacia and Upjohn Inc, Kalamazoo, MI 49001, USA
    Blood 88:2973-9. 1996
    ..Both P- and E-selectin are likely to play important roles in the development and maintenance of inflammatory diseases...
  63. ncbi CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation
    Xuefei Zhu
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Uveitis Study Center, Sun Yat Sen University, 54 South Xianlie Road, Guangzhou 510060, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 245:1549-57. 2007
    ..ACAID is a model of immune privilege in the eye. Relatively little is known about the role and phenotype of these regulatory CD4(+)CD25(+) T cells in ACAID...
  64. ncbi Local cytokine levels associated with delayed-type hypersensitivity responses: modulation by gender, ovariectomy, and estrogen replacement
    Lisa J Ma
    Division of Biomedical Sciences, The University of California, Riverside, CA 92521, USA
    J Endocrinol 193:291-7. 2007
    ..The results further suggest that IL-6 may play a role in predisposing to a larger DTH response, while IL-4 levels seem more important during an active response...
  65. ncbi Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 171:2314-9. 2003
    ..Our results suggest that PT-B is largely responsible for the disease-enhancing properties of PT...
  66. ncbi Injection of soluble antigen into the anterior chamber of the eye induces expansion and functional unresponsiveness of antigen-specific CD8+ T cells
    Kyle C McKenna
    Departments of Ophthalmology and Pathology, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA
    J Immunol 169:5630-7. 2002
    ..c. We conclude that tolerance of CTL responses in mice given Ag via the a.c. results from unresponsiveness of Ag-specific CD8(+) T cells...
  67. ncbi OVA-specific CD8+ T cells do not express granzyme B during anterior chamber associated immune deviation
    Yalin Ren
    Zhongshan Ophthalmic Center, Uveitis Study Center, Sun Yat Sen University, Key Laboratory of Ophthalmology, Ministry of Education, Guangzhou, People s Republic of China
    Graefes Arch Clin Exp Ophthalmol 244:1315-21. 2006
    ..To examine antigen (Ag)-specific CTL response during anterior chamber associated immune deviation (ACAID)...
  68. ncbi A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis
    Takeshi Kezuka
    Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tate machi, Hachioji City, Tokyo, 193 8639, Japan
    Arch Ophthalmol 120:1183-8. 2002
    We recently reported that acute retinal necrosis in humans develops in a setting where delayed hypersensitivity (DH) to the varicella-zoster virus (VZV) antigen was absent, implying that virus-specific DH mitigates against acute retinal ..
  69. ncbi Effects of oestradiol and the oestrogen antagonist Ici 182,780 on the delayed type hypersensitivity (DTH) index and on serum levels of IgM and IgG in ovariectomised Balb/C and MRL/Mp-Lpr/Lpr mice, a model of systemic lupus erythematosus (SLE)
    Y Y Dhaher
    Medicare, Bareed, Ramallah, PNA, Israel
    Autoimmunity 33:237-43. 2001
    ..ICI 182,780 depressed spleen weights in both strains. Oestrogen may influence B cell function through ICI 182,780-sensitive receptors, and ICI 182,780 may have agonist actions on the immune system. (200 words)...
  70. pmc Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent
    U Islander
    Department of Rheumatology and Inflammation Research at the Sahlgrenska Academy, Goteborg, Sweden
    Clin Exp Immunol 139:210-5. 2005
    ..Thus, our study is the first to show that estren inhibits T lymphopoiesis via ER-independent pathways, whereas its suppressive effects on inflammation are ER-dependent...
  71. ncbi Delayed hypersensitivity skin testing to mumps and Candida albicans antigens is normal in middle-aged HTLV-I- and-II-infected U.S. cohorts
    E L Murphy
    University of California San Francisco, 94143, USA. murphy.itsa.ucsf.edu
    AIDS Res Hum Retroviruses 17:1273-7. 2001
    ..It has been reported that human T cell lymphotropic virus (HTLV)-I-infected persons in Japan have decreased delayed hypersensitivity skin test reactivity to tuberculin purified protein derivative (PPD), but HTLV-I- or -II-infected persons ..
  72. ncbi IV. Clinical aspects of delayed hypersensitivity in lungs: pathophysiology of hypersensitivity disorders in clinics
    K Hirata
    First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545-8585 Japan. kazuto h@ msic.med.osaka-cu.ac.jp
    Microsc Res Tech 53:307-12. 2001
    ....
  73. pmc Impaired primary T cell responses in L-selectin-deficient mice
    J Xu
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 183:589-98. 1996
    ..L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization...
  74. ncbi Active-specific immunotherapy for melanoma
    M S Mitchell
    Department of Medicine, University of Southern California School of Medicine, Los Angeles
    J Clin Oncol 8:856-69. 1990
    ....
  75. ncbi CD1-dependent natural killer (NK1.1(+)) T cells are required for oral and portal venous tolerance induction
    Julie A Margenthaler
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 104:29-35. 2002
    ..Because NK1.1(+) T cells express the Fas ligand and produce high levels of the immunosuppressive cytokine, IL-4, they may play a role in both activated T-cell apoptosis and a Th1 to Th2 immune shift, thus promoting tolerance induction...
  76. ncbi Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice
    S Beissert
    Massachusetts General Hospital Harvard Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Boston, USA
    J Invest Dermatol 107:553-7. 1996
    ....
  77. ncbi Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells
    Hiroshi Keino
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 47:1047-55. 2006
    ..The current study was conducted to investigate the possibility that these T regs express CD25 and are derived from natural CD4+CD25+ T cells...
  78. ncbi Severe respiratory symptoms to oxaliplatin infusion: a case report of delayed hypersensitivity reaction
    Simona Potenza
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Invest New Drugs 28:185-6. 2010
    ..In this case report we present a delayed hypersensitivity reaction, consisting in dysesthesia and laryngeal spasm developed 10 h after the sixth administration of ..
  79. ncbi Serious delayed hypersensitivity reaction to oxaliplatin
    R S de Vries
    Ann Oncol 17:1723-4. 2006
  80. ncbi An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity
    Amanda Jane Ruth
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Immunol 173:136-44. 2004
    ..Effector cell activation, renal DTH-like injury, and dermal DTH require direct Th1 CD154/macrophage CD40 interactions...
  81. ncbi HCV core protein-expressing DNA vaccine induces a strong class I-binding peptide DTH response in mice
    Nelson Acosta-Rivero
    Division of Vaccines, Center for Genetic Engineering and Biotechnology, P O Box 6162, C P 10600, Havana, Cuba
    Biochem Biophys Res Commun 314:781-6. 2004
    ..Hence, pIDKCo could prime a strong HCcAg-specific T-cell response in mice with the potential capacity to exert their specific effector functions in peripheral tissues...
  82. ncbi A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration
    Asya Rolls
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    FASEB J 20:547-9. 2006
    ....
  83. pmc Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-gamma via CXCR3 chemokines
    Moe Akahira-Azuma
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 0813, USA
    Immunology 111:306-17. 2004
    ..These results suggest that both a Th2-like (IL-5, IL-4 and STAT-6) and a Th1-like (IFN-gamma, IP-10, CXCR3) pathway contribute to eosinophil recruitment in early delayed-type hypersensitivity...
  84. ncbi Abnormal anterior chamber associated immune deviation (ACAID) in 129-strain mice
    John Herndon
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, Saint Louis, MO 63110, USA
    Ocul Immunol Inflamm 14:7-12. 2006
    ..To characterize anterior chamber immune deviation (ACAID) in 129-strain and mixed 129-strain mice...
  85. ncbi CDllc+ cells modulate pulmonary immune responses by production of indoleamine 2,3-dioxygenase
    Kena A Swanson
    Department of Microbiology and Immunology, Indiana University School of Medicine, 1001 West Tenth Street, OPW 425, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 30:311-8. 2004
    ..Collectively these data show that lung iAPCs contribute to local regulation of cellular immune responses by production of IDO...
  86. ncbi IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  87. ncbi Effect of chemical adjuvants on DNA vaccination
    Huali Jin
    State Key Laboratory for Agro Biotechnology, Department of Physiology, College of Biology, China Agricultural University, Beijing
    Vaccine 22:2925-35. 2004
    ..These results demonstrate the usefulness of various chemicals, particularly levamisole, for modulating the outcome of DNA vaccination, in both the intensity of the immune response and the polarity of such response (toward Th1)...
  88. ncbi T-h-2 immunity and CD3+CD45RBlow-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope
    Vivekanandhan Aravindhan
    Department of Immunology, Tuberculosis Research Centre, Chennai, India
    FEMS Immunol Med Microbiol 47:45-55. 2006
    ..Thus, this epitope delivery system induced strong epitope-specific T-h-2 polarization...
  89. ncbi Starch microparticles as an adjuvant in immunisation: effect of route of administration on the immune response in mice
    Linda Stertman
    Department of Pharmacy, Uppsala University, Biomedical Centre, P O Box 580, SE 751 23, Sweden
    Vaccine 22:2863-72. 2004
    ..In conclusion, our results show that the profile of an immune response depends on the route of administration, which should be considered when developing new vaccines or new routes of administration...
  90. pmc Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation
    J X Wang
    First Department of Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Br J Pharmacol 150:652-61. 2007
    ..Artemisinin and its derivatives exhibit potent immunosuppressive activity. The purpose of the current study was to examine the immunosuppressive activity of artemether directly on T lymphocytes and to explore its potential mode of action...
  91. ncbi Aggravated infection in mice co-administered with Mycobacterium tuberculosis and the 27-kDa lipoprotein
    Avi Hai Hovav
    Department of Clinical Microbiology, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Microbes Infect 8:1750-7. 2006
    ..Altogether, these data suggest that the 27-kDa lipoprotein plays a role in Mtb infection by inducing increased suppression of the immune response due to elevated NO production...
  92. pmc The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response
    M Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    Clin Exp Immunol 152:345-53. 2008
    ..p53 is involved in the modulation of adaptive and innate immune responses relevant to arthritis models and is also involved in the modulation of severity of AIA by both cell-cycle dependent and cell-cycle-independent mechanisms...
  93. ncbi Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB/c mice
    Soheila Ajdary
    Immunology Department, Pasteur Institute of Iran, Pasteur Ave, Tehran IR, Iran
    Vaccine 25:4595-601. 2007
    ..The immune responses induced by oral administration of encapsulated BCG were equal to or better than the responses induced by standard BCG vaccination...
  94. ncbi Leishmania donovani-derived lipophosphoglycan plus BCG induces a Th1 type immune response but does not protect Syrian golden hamsters (Mesocricetus auratus) and BALB/c mice against Leishmania donovani
    W K Tonui
    Centre for Biotechnology Research and Development, Kenya Medical Research Institute, PO Box 54840, Nairobi, Kenya
    Onderstepoort J Vet Res 70:255-63. 2003
    ..These data nevertheless suggest that it may be rewarding to further evaluate the potential of LPG as a vaccine candidate in leishmaniosis using other adjuvants, which may enhance its immunogenicity...
  95. ncbi Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation
    Kahwa Noh
    Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul 110 799, South Korea
    Immunol Lett 98:63-72. 2005
    ..Based on these results, we suggest that an exogenously administered mega-dose of Vitamin C shifts immunity in Balb/c mouse toward Th1 and that these affects occur only when Vitamin C is administered during T cell activation...
  96. ncbi A structurally altered D,L-amino acid TCRalpha transmembrane peptide interacts with the TCRalpha and inhibits T-cell activation in vitro and in an animal model
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Biochemistry 46:2317-25. 2007
    ....
  97. ncbi Cellular immune response induced by Salmonella enterica serotype Typhi iron-regulated outer-membrane proteins at peripheral and mucosal levels
    Shaloo Sood
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Med Microbiol 54:815-21. 2005
    ..The results of this study suggest a role for S. Typhi IROMPs in modulating the cellular immune response at peripheral and mucosal levels...
  98. ncbi Periplocoside E, an effective compound from Periploca sepium Bge, inhibited T cell activation in vitro and in vivo
    Yi Na Zhu
    Laboratories of Immunopharmacology, Graduate School of the Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, People s Republic of China
    J Pharmacol Exp Ther 316:662-9. 2006
    ..This study provided evidence to understand the therapeutic effects of P. sepium Bge and indicated that this herb is appropriate for treatment of T cell-mediated disorders, such as autoimmune diseases...
  99. ncbi Effects of Brx-019 (acetic acid 3,6a,9-triacetoxy-6,6a,7, 11b-tetrahydro-indeno [2,1-c] chromen-10-yl ester), a Brazilin derivative, on T cell-mediated immune responses in multiple low dose streptozotocin-induced diabetic C57BL/6 male mice
    Wie Jong Kwak
    College of Pharmacy, Seoul National University, Seoul, Korea
    Arzneimittelforschung 55:541-8. 2005
    ..These results suggest that Brx-019 might improve immunity in diabetic mice by increasing IL-2 production in splenocytes and responsiveness of splenocytes to IL-2, which were suppressed in MLDS-diabetes...
  100. ncbi (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
    Ru Zhou
    Laboratory of Immunopharmacology, Graduate School of the Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
    Int Immunopharmacol 5:1895-903. 2005
    ..The results suggested that LLDT-8 had immunosuppressive activities in both cellular and humoral immune responses. LLDT-8 might be a potential therapeutic agent for immune-related diseases...
  101. ncbi Immune response to a major Trypanosoma cruzi antigen, cruzipain, is differentially modulated in C57BL/6 and BALB/c mice
    Natalia Guiñazu
    Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Haya de la Torre y Medina Allende s n, 5000 Cordoba, Argentina
    Microbes Infect 6:1250-8. 2004
    ..Thus, the differential immune response elicited in C57BL/6 and BALB/c mice upon cruzipain immunization is implicated in the resistance or pathogenesis of experimental Chagas' disease...

Research Grants62

  1. CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVO
    Salvador Gonzalez; Fiscal Year: 2002
    ..The ICD is produced by the toxic effect of certain chemicals on the skin while ACD is induced by a delayed hypersensitivity response of the host to an antigenic chemical...
  2. POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY
    KIMBER WHITE; Fiscal Year: 2011
    ..sensitizing agents, optimizing the use of alternative antigens for evaluation of antibody responses and delayed hypersensitivity responses and examining potential windows of vulnerability in the developing immune system...
  3. POTENTIAL FOR ENVIRONMENTAL AND THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY
    KIMBER WHITE; Fiscal Year: 2010
    ..sensitizing agents, optimizing the use of alternative antigens for evaluation of antibody responses and delayed hypersensitivity responses and examining potential windows of vulnerability in the developing immune system...
  4. Peripheral Neural Mechanisms of Inflammatory Itch and Pain
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..ACD is a Type IV delayed hypersensitivity reaction initiated by T lymphocytes specific for an allergen...
  5. TRICHOPHYTON AND ASPERGILLUS IMMUNOLOGY AND LUNG DISEASE
    Thomas Platts Mills; Fiscal Year: 1999
    ..extracts gives rise to immediate or delayed reactions; the plan is to fully purify a protein that gives delayed hypersensitivity (DH) responses...
  6. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
    ..lesions to investigate the hypothesis that the chronic inflammatory reaction there is driven by delayed hypersensitivity to antigens in the lesion...
  7. EFFECTS OF AGING ON DELAYED HYPERSENSITIVITY IN MICE
    ALFRED CROWLE; Fiscal Year: 1980
    ....
  8. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ..Immunogenic inflammation associated with delayed hypersensitivity reactions can grossly distort the visual axis resulting in blindness...
  9. INFECTION MODEL OF LEPROMATOUS LEPROSY
    Frank Collins; Fiscal Year: 1991
    ..provide an important probe for investigating the nature of the epitopes responsible for the induction of delayed hypersensitivity and acquired resistance in the infected host...
  10. COMPARATIVE PATHOGENESIS OF MEASLES AND SIMIAN AIDS
    Michael McChesney; Fiscal Year: 2000
    ..control viral replication in both, but this response is insufficient in SIV infection; (2) antiviral delayed hypersensitivity (defined as CD4-induced-suppression of virus replication in macrophages) is not elicited by either virus, ..
  11. ANTERIOR CHAMBER INFLUENCE ON OCULAR ANTIGENS
    J Streilein; Fiscal Year: 1999
    ..immune responses to anterior chamber antigens are deviant in that certain types of immune effectors (delayed hypersensitivity and complement fixing antibodies) are selectively deleted and/or suppressed, whereas other effectors (..
  12. PROSTAGLANDIN BIOSYNTHESIS IN LUNG MACROPHAGES
    Wei Hsueh; Fiscal Year: 1980
    ..that lysosomal enzyme release and arachidonic acid-PG production by macrophages are dissociated during delayed hypersensitivity. The possible role of lymphocytes on the suppression of arachidonic acid-PG production by macrophages in ..
  13. ANTERIOR CHAMBER INFLUENCE ON OCULAR ANTIGENS
    Joan Stein Streilein; Fiscal Year: 2005
    ..immune responses to anterior chamber antigens are deviant in that certain types of immune effectors (delayed hypersensitivity and complement-fixing antibodies) are selectively suppressed, whereas other effectors (cytotoxic T cells, ..
  14. RECOMBINANT TUMOR VACCINE--CATBRM
    Albert LoBuglio; Fiscal Year: 1999
    ..Patients will be, monitored for CEA-specific cellular immune responses (delayed hypersensitivity skin tests, T cell lymphocyte proliferation and lymphokine release profiles and cytolytic T cell ..
  15. CELL-MEDIATED IMMUNE RESPONSE TO INTRAOCULAR TUMORS
    Bruce Ksander; Fiscal Year: 1993
    ..to participate in the immune-mediated rejection of tumors: cytotoxic T cells (Tc) and mediators of delayed hypersensitivity (Tdh)...
  16. SELECTIVE STIMULATION OF CELL-MEDIATED CANCER IMMUNITY
    Robert Hunter; Fiscal Year: 1980
    ..conjugated with a lipid (dodecanoic acid) selectively stimulates a type of cell-mediated immunity, delayed hypersensitivity (DTH) instead of the antibody responses usually produced by stimulation with native BSA...
  17. MAREK'S DISEASE HERPES VIRUS ANTIGENS
    LELAND VELICER; Fiscal Year: 1980
    ..relationship, if any, to each other, virion structural proteins, neutralizing antibody, interferon, and delayed hypersensitivity in infected birds...
  18. MACROPHAGE PROLIFERATION AND ACTIVATION
    John Hadden; Fiscal Year: 1980
    b>Delayed hypersensitivity in vivo is associated with macrophage proliferation which occurs concomitant to the development of lymphocyte sensitization...
  19. Hyperbaric oxygen and atherosclerosis
    Ladislav Dory; Fiscal Year: 2007
    ..We also observed a significant decrease in spleen size and a profound (>95%) decrease in delayed hypersensitivity to oxLDL, as a result of HBO treatment, suggesting that this treatment also targets the immune system...
  20. RESPIRATORY HAZARDS OF SWINE CONFINEMENT WORKERS
    Kelley Donham; Fiscal Year: 1980
    ..may experience: 1) chronic irritation of the upper respiratory tract; 2) immediate hypersensitivity; 3) delayed hypersensitivity; 4) acute severe, disabling respiratory symptoms...
  21. IMMUNOREGULATORY MECHANISMS IN THE RHEUMATIC DISEASES
    David Horwitz; Fiscal Year: 1980
    ..found with these in vitro methods will be compared with disease activity and an evaluation of delayed hypersensitivity to common skin test antigens...
  22. OPIATES, IMMUNE FUNCTION, AND CONTROL OF HIV INFECTION
    Rob Roy MacGregor; Fiscal Year: 1991
    ..5. Delayed hypersensitivity will be measured in vivo to a battery of antigens...
  23. GENERAL CLINICAL RESEARCH CENTER
    John Hutton; Fiscal Year: 1990
    ..All subjects will be screened for serologic abnormalities seen in SLE and have delayed hypersensitivity skin tests performed...
  24. PATHOBIOLOGY OF MACROPHAGE-FIBRONECTIN INTERACTIONS
    Livingston Van De Water; Fiscal Year: 1993
    ..this methodology, as well as RNA mapping and immunocytochemistry, to determine if macrophages in delayed hypersensitivity reactions and granulomas also express alternatively spliced forms of fibronectin...
  25. Regulation of Ocular Tolerance by Gamma/delta T Cells
    JUDITH KAPP; Fiscal Year: 2004
    ..placed in the anterior chamber of the eye induce a systemic form of tolerance, called ACAID, in which delayed hypersensitivity and complement fixing antibody responses to an immunogenic form of the antigen are inhibited...
  26. INITIATION OF T CELL IMMUNE RESPONSES IN GUT MUCOSA
    Subhash Gautam; Fiscal Year: 1990
    ..in gut associated lymphoid tissues (GALT) in the development of mucosal T cell-mediated responses of delayed hypersensitivity (DH) and cell-mediated lympholysis (CML) to orally administered hapten...
  27. INDUCTION OF DELAYED HYPERSENSITIVITY TO SIV
    Michael McChesney; Fiscal Year: 1999
    ..These outcomes would support the concept of antiviral DTH as a protective immune response to target with a novel HIV vaccine. ..
  28. OCULAR HERPES MODEL
    JUDITH WHITTUM HUDSON; Fiscal Year: 1990
    ..Systemic immunity is aberrant because anti-HSV delayed hypersensitivity is actively suppressed while anti-HSV antibody responses are intact...
  29. IMMUNE DYSFUNCTION--NURSING MEASURE IN HEART FAILURE
    Donna Vredevoe; Fiscal Year: 2002
    ..Almost half of such patients no longer can mount a delayed hypersensitivity responses to intradermal challenge with recall antigens...
  30. THE CELLULAR BASIS OF ACQUIRED IMMUNOLOGIC TOLERANCE
    Alan Kaplan; Fiscal Year: 1980
    ..observation that A/He and C57BL/6 mice respond oppositely with respect to antibody production and delayed hypersensitivity to human gamma-globulin provides a useful model to study the regulation of these immunologic functions...
  31. STRUCTURE OF IMMUNOLOGIC DETERMINANTS OF PROTEINS
    Joel Goodman; Fiscal Year: 1991
    ..4. Individual T cell clones manifest complex functional activities, including help, delayed hypersensitivity (DTH) and cytotoxicity, all of which are Ia-restricted and antigen-dependent...
  32. Midcareer Vulvodynia Research and Mentoring Project
    Barbara Reed; Fiscal Year: 2007
    ..psychophysical sensory responses of women with vulvodynia and controls, assessment of the immediate and delayed hypersensitivity reactions and cytokine correlates, evaluation of neuroimmunological changes following treatment, and the ..
  33. IL-2 LIPSOMES AS DELIVERY AGENTS FOR IMMUNOTHERAPEUTICS
    PAULA KONIGSBERG; Fiscal Year: 1991
    ..study will be to show that SMI inhibits the growth of antigen-specific T cells in oxazolanone-induced delayed hypersensitivity produced in rats...
  34. SEQUENTIAL INTERACTION OF MACROPHAGES AND T CELL SUBSETS
    SHMUEL LIVNAT; Fiscal Year: 1980
    ..in antibody production, helper cells for T cells in the generation of cytotoxic cells, and cell mediating delayed hypersensitivity will be tested...
  35. UNEXPRESSED, RESTORABLE DELAYED HYPERSENSITIVITY
    Jon Green; Fiscal Year: 1980
    The central focus of the project involves examination of cryptic delayed hypersensitivity (CDH) in the mouse...
  36. EFFECTS OF UV EXPOSURE ON THE PATHOGENESIS OF DISEASE
    Margaret Kripke; Fiscal Year: 1990
    ..The effects of UV irradiation on delayed hypersensitivity, antibody production, and suppressor cell formation to candida antigens will be assessed, in addition to ..
  37. LIPIDS CONTROLLING STAPH AUREUS SURVIVAL IN VIVO
    FRANK KAPRAL; Fiscal Year: 1990
    ..Studies will be done to determine whether diabetes, steroid administration, ether inhalation, or delayed hypersensitivity will alter the host's ability to synthesize the bactericidal lipids in abscesses...
  38. SUPPRESSOR CELL MECHANISMS AND GENETICS IN TOLERANCE
    Stephen Miller; Fiscal Year: 1980
    ..e., T helper, pre- or mature delayed hypersensitivity effector cells...
  39. HOST RESPONSE TO INTESTINAL FLORA
    Philip Carter; Fiscal Year: 1980
    ..Characterization of the cells in the rodent Peyer's patches will be studied using current technology. Control of secretory IgA production and delayed hypersensitivity responses at mucosal surfaces will be studied.
  40. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  41. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  42. AUTOLOGOUS HAPTEN MODIFIED VACCINE FOR HUMAN CANCER
    David Berd; Fiscal Year: 2001
    ..This work may lead to the development of reagents useful in identifying the target antigens. ..
  43. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  44. PTLD: cytokine production and gene polymorphisms
    Robert Baiocchi; Fiscal Year: 2005
    ..Our overall goal is to use this data as a springboard for R01 proposals to study the molecular epidemiology of PTLD and to perform prospective therapeutic clinical trials in PTLD patients. ..
  45. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
  46. ANXIETY, DEPRESSION, OPTIMISM, AND CELLULAR IMMUNITY
    SUZANNE SEGERSTROM; Fiscal Year: 2005
    ....
  47. In vivo testing of the role of TGFb in PTLD
    Anne Vanbuskirk; Fiscal Year: 2003
    ..The results from this pilot study will indicate whether TGFb is crucial to tumor formation in the SCID-Hu PBL mouse model. ..
  48. Pre-Conditioning Pancreatic Islets for Transplantation
    Ginny Bumgardner; Fiscal Year: 2006
    ..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
  49. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  50. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  51. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  52. CONTINUED RENOVATION OF RESEARCH BLDG
    J Streilein; Fiscal Year: 2002
    ..Once Segment 3a is accomplished, space will be available to carry out Segment 3b. At the completion of the renovation program, the Institute will have a physical facility sufficient to meet present research needs. ..
  53. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
    ..Furthermore, studies of inhibition of HO-1 and IL-10 will be carried out to determine functional association of 15d-PGJ2 with HO-1 and IL-10. ..
  54. ESTROGEN EFFECTS ON ANXIETY RELATED NEURAL SYSTEMS
    Margaret Altemus; Fiscal Year: 2004
    ..This field of investigation is likely to improve understanding and treatment of anxiety and affective disorders, both of which are widely prevalent, chronic public health problems. ..
  55. T CELL ACTIVATION FOR CANCER IMMUNOTHERAPY
    Alfred Chang; Fiscal Year: 2008
    ..We have extensive experience in the conduct of adoptive immunotherapy and vaccine trials in humans that will allow translation of these findings. ..