hypersensitivity

Summary

Summary: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Top Publications

  1. pmc House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
  2. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
  3. pmc Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)
    Neil Pearce
    Centre for Public Health Research, Massey University Wellington Campus, Private Box 756, Wellington, New Zealand
    Thorax 62:758-66. 2007
  4. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
  5. ncbi Discovering susceptibility genes for asthma and allergy
    Donata Vercelli
    Functional Genomics Laboratory, Arizona Respiratory Center, Department of Cell Biology and The Bio5 Institute, University of Arizona, PO Box 245044, Tucson, Arizona 85724 5044, USA
    Nat Rev Immunol 8:169-82. 2008
  6. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
  7. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
  8. ncbi Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
  9. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
  10. ncbi Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
    Sylvie Amu
    Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 125:1114-1124.e8. 2010

Detail Information

Publications320 found, 100 shown here

  1. pmc House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
    ..Our data identify an innate immune function of airway epithelial cells that drives allergic inflammation via activation of mucosal DCs...
  2. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  3. pmc Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)
    Neil Pearce
    Centre for Public Health Research, Massey University Wellington Campus, Private Box 756, Wellington, New Zealand
    Thorax 62:758-66. 2007
    ..In phase III the phase I survey was repeated in order to assess changes over time...
  4. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    ..The information that has emerged suggests new therapeutic directions for combating allergic disease...
  5. ncbi Discovering susceptibility genes for asthma and allergy
    Donata Vercelli
    Functional Genomics Laboratory, Arizona Respiratory Center, Department of Cell Biology and The Bio5 Institute, University of Arizona, PO Box 245044, Tucson, Arizona 85724 5044, USA
    Nat Rev Immunol 8:169-82. 2008
    ..Despite the achievements made in asthma genetics formidable challenges remain. The development of novel, powerful tools for gene discovery, and a closer integration of genetics and biology, should help to overcome these challenges...
  6. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...
  7. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
    ..These data demonstrate that inhibition of microglial activation attenuated the development of behavioral hypersensitivity in a rat model of neuropathic pain but had no effect on the treatment of existing mechanical allodynia and ..
  8. ncbi Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
    ..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
  9. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
    ..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization...
  10. ncbi Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
    Sylvie Amu
    Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 125:1114-1124.e8. 2010
    ..Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation and anaphylaxis via IL-10 and B cells...
  11. pmc T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity
    Michael Costigan
    UCL Department of Neuroscience, Physiology and Pharmacology and UCL Department of Biochemistry, University College London, London WC1 EBT, United Kingdom
    J Neurosci 29:14415-22. 2009
    Partial peripheral nerve injury in adult rats results in neuropathic pain-like hypersensitivity, while that in neonatal rats does not, a phenomenon also observed in humans...
  12. ncbi Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
    E M Hollams
    Telethon Institute for Child Health, 100 Roberts Road, Subiaco WA 6008, Australia
    Eur Respir J 38:1320-7. 2011
    ..In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age...
  13. ncbi The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
    Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast cells by allergen-specific IgE antibodies bound to their high-..
  14. ncbi Treatment strategies for allergy and asthma
    Stephen T Holgate
    IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Nat Rev Immunol 8:218-30. 2008
    ....
  15. pmc Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity
    M Teresa Audicana
    Allergy and Clinical Immunology Department, Santiago Apostol Hospital, C Olaguibel 29, 01004 Vitoria Gasteiz, Basque Country, Spain
    Clin Microbiol Rev 21:360-79, table of contents. 2008
    ..During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated ..
  16. pmc Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells
    Isabelle C Arnold
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    J Clin Invest 121:3088-93. 2011
    ..Our results thus provide experimental evidence for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma...
  17. ncbi The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
    Lancet 376:835-43. 2010
    ....
  18. ncbi Immunological mechanisms of allergen-specific immunotherapy
    Mark Larché
    Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Nat Rev Immunol 6:761-71. 2006
    ..This article reviews the development of allergen-specific immunotherapy, our current understanding of its mechanisms of action and its future prospects...
  19. pmc Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    Zoulfia Allakhverdi
    Laboratory on Allergy, CHUM Research Center, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    J Exp Med 204:253-8. 2007
    ..Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases...
  20. ncbi Phthalate exposure and asthma in children
    C G Bornehag
    Public Health Sciences, Karlstad University, Karlstad, Sweden
    Int J Androl 33:333-45. 2010
    ..But the important questions of clinical relevance of real life exposure and identification of molecular targets that can explain interactions largely remain to be answered...
  21. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
    ..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
  22. pmc Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
    QiQi Zhou
    Department of Medicine, Ohio State University, Columbus, OH, USA
    Pain 146:41-6. 2009
    ..We have also found that increased intestinal membrane permeability is associated with visceral and thermal hypersensitivity in this subset of D-IBS patients...
  23. ncbi The effect of infections on susceptibility to autoimmune and allergic diseases
    Jean Francois Bach
    INSERM Unité 25, Institut de Recherches Necker Enfants Malades, Hopital Necker, Paris, France
    N Engl J Med 347:911-20. 2002
  24. pmc Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010
    ..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  25. pmc AllergoOncology: the role of IgE-mediated allergy in cancer
    E Jensen-Jarolim
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University Vienna, Austria
    Allergy 63:1255-66. 2008
    ..It is strongly suggested that the evolving new field AllergoOncology will give new insights into the role of IgE-mediated allergy in malignancies, possibly opening new avenues for tumor therapy...
  26. ncbi A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force
    S G Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska Hospital, Stockholm, Sweden
    Allergy 56:813-24. 2001
    ..The nomenclature is based on the present knowledge of the mechanisms which initiate and mediate allergic reactions. However, the intention has not been to revise the nomenclature of nonallergic hypersensitivity.
  27. ncbi Burden of allergic disease in the UK: secondary analyses of national databases
    R Gupta
    Department of Community Health Sciences, St George s Hospital Medical School, London, UK
    Clin Exp Allergy 34:520-6. 2004
    ..Although allergy represents an important source of patient morbidity and healthcare utilization, there is little reliable information on the overall disease burden posed by allergic conditions in the UK...
  28. pmc Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
    ....
  29. ncbi Cytokines, allergy, and asthma
    P Ly Ngoc
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Allergy Clin Immunol 5:161-6. 2005
    ..This review examines recent articles on the relationship of cytokines to allergy and asthma with particular emphasis on immune mechanisms involved in disease development in early life...
  30. ncbi Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens
    Mirela Curin
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 154:258-63. 2011
    ..g. dog hair and dander. Due to different starting material and extraction methods used, it is likely that extracts differ regarding their allergen contents...
  31. ncbi Probiotics during weaning reduce the incidence of eczema
    Christina E West
    Department of Clinical Sciences, Pediatrics, Umea University, Umeå S 901 85, Sweden
    Pediatr Allergy Immunol 20:430-7. 2009
    ..g., eczema. The higher Th1/Th2 ratio in the probiotic compared with the placebo group suggests enhancing effects of Lactobacillus F19 on the T cell-mediated immune response...
  32. pmc Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma
    E C Matsui
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy 65:1414-22. 2010
    ..Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic...
  33. ncbi Geography of house dust mite allergens
    Wayne R Thomas
    Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, 100 Roberts Rd, Subiaco 6008, Western Australia
    Asian Pac J Allergy Immunol 28:211-24. 2010
    ..To consider how the different distribution of house dust mites and their species in different geographical locations affects the allergens in the environment and their use...
  34. ncbi Stinging insect hypersensitivity: a practice parameter update 2011
    David B K Golden
    Joint Council of Allergy, Asthma and Immunology, 50 N Brockway St, 3 3, Palatine, IL 60067, USA
    J Allergy Clin Immunol 127:852-4.e1-23. 2011
    ..The AAAAI and the ACAAI have jointly accepted responsibility for establishing "Stinging insect hypersensitivity: a practice parameter update II...
  35. ncbi Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice
    Unni C Nygaard
    Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Toxicol Sci 109:113-23. 2009
    ..This study demonstrates that CNTs promote allergic responses in mice...
  36. pmc Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies
    Lennart Bråbäck
    Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Environ Health 8:17. 2009
    ..Future studies should also evaluate effects of traffic exhaust on the development and long term outcome of different phenotypes of asthma and wheezing symptoms...
  37. pmc Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
    Rebecca P Seal
    Department of Physiology, University of California, San Francisco School of Medicine, California 94143, USA
    Nature 462:651-5. 2009
    ..The loss of VGLUT3 specifically impairs mechanical pain sensation, and in particular the mechanical hypersensitivity to normally innocuous stimuli that accompanies inflammation, nerve injury and trauma...
  38. pmc IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
    Elizabeth E Forbes
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
    J Exp Med 205:897-913. 2008
    ..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy...
  39. ncbi Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines
    Thierry Batard
    Recherche et Developpement, Stallergènes, Antony, France
    Int Arch Allergy Immunol 140:295-305. 2006
    ..Hence large quantities of well-characterized HDM extracts are needed to prepare pharmaceutical-grade allergy vaccines. To this aim, the present study was undertaken to define optimal conditions for large-scale cultures...
  40. ncbi Do helminth parasites protect against atopy and allergic disease?
    C Flohr
    Institute of Clinical Research and Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Allergy 39:20-32. 2009
    ..Lack of parasite exposure in such hosts might lead to hypersensitivity to seemingly minor environmental allergen stimuli...
  41. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  42. ncbi Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial
    Angie L Taylor
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 119:184-91. 2007
    ..Despite preliminary evidence, the role of probiotics in allergy prevention is unclear...
  43. ncbi Mechanisms of immunotherapy to aeroallergens
    M H Shamji
    Allergy and Clinical Immunology Section, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Clin Exp Allergy 41:1235-46. 2011
    ..are accompanied by a reduction and/or a redirection of underlying antigen-specific Th2-type T cell-driven hypersensitivity to the allergen(s) used for therapy...
  44. ncbi Characterization of a common susceptibility locus for asthma-related traits
    Tarja Laitinen
    GeneOS Limited, 00251 Helsinki, Finland
    Science 304:300-4. 2004
    ..The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma...
  45. ncbi Genetics of allergic disease
    John W Holloway
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 125:S81-94. 2010
    ....
  46. ncbi Asthma and allergies in rural areas of Europe
    Erika von Mutius
    University Children s Hospital, Lindwurmstr 4, D 80337, Munich, Germany
    Proc Am Thorac Soc 4:212-6. 2007
    ..How this activation of innate immunity is translated into reduced IgE-specific adaptive immune responses remains to be elucidated, but may invoke a number of distinct allergen-specific steps...
  47. ncbi Suppression of TH2-type allergic reactions by helminth infection
    Padraic G Fallon
    Institute of Molecular Medicine, Department of Clinical Medicine, Trinity College Dublin Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Nat Rev Immunol 7:220-30. 2007
    ..Harnessing current mechanistic studies for translational research into helminth infections and atopy might have potential for the identification of novel biomarkers, and even therapeutics, in allergic diseases...
  48. ncbi Gender difference, sex hormones, and immediate type hypersensitivity reactions
    W Chen
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munich, Germany
    Allergy 63:1418-27. 2008
    ..The limited data on the prevalence of immediate hypersensitivity to hymenoptera venom show controversial results...
  49. ncbi Idiopathic environmental intolerance attributed to electromagnetic fields (formerly 'electromagnetic hypersensitivity'): An updated systematic review of provocation studies
    G James Rubin
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Bioelectromagnetics 31:1-11. 2010
    Idiopathic Environmental Intolerance attributed to electromagnetic fields (IEI-EMF; formerly 'electromagetic hypersensitivity') is a medically unexplained illness in which subjective symptoms are reported following exposure to electrical ..
  50. ncbi Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases
    Susan L Prescott
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 131:23-30. 2013
    ..In this context allergic disease provides a very important early target to assess the effectiveness of environmental strategies to reduce immune dysregulation...
  51. ncbi Metal allergy--a review on exposures, penetration, genetics, prevalence, and clinical implications
    Jacob P Thyssen
    National Allergy Research Centre and Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Chem Res Toxicol 23:309-18. 2010
    ..Furthermore, metal allergy has been associated with device failure following insertion of intracoronary stents, hip and knee prostheses, as well as other implants. This area is in need of more research...
  52. ncbi Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
    Stacey R Dillon
    Department of Immunology, ZymoGenetics, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
    Nat Immunol 5:752-60. 2004
    ..IL-31 receptor expression was increased in diseased tissues derived from an animal model of airway hypersensitivity. These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that ..
  53. ncbi Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjects
    B J Hales
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia
    Thorax 63:221-7. 2008
    ..The immune response to bacterial antigens on mucosal surfaces may be modified in individuals allergic to aeroallergens due to a maturational or genetic difference or from the interaction between inhaled allergens and bacteria at the mucosa...
  54. ncbi Allergy and risk of glioma: a meta-analysis
    C Chen
    Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Eur J Neurol 18:387-95. 2011
    ..The significant association remained even after excluding the bias of proxy reporting (OR=0.61; 95% CI: 0.50-0.75, P<0.001). We conclude that allergic conditions may significantly reduce the risk of glioma...
  55. pmc The association between phthalates in dust and allergic diseases among Bulgarian children
    Barbara Kolarik
    Technical University of Denmark, Department of Mechanical Engineering, International Centre for Indoor Environment and Energy, Lyngby, Denmark
    Environ Health Perspect 116:98-103. 2008
    ..Recent studies have identified associations between the concentration of phthalates in indoor dust and allergic symptoms in the airways, nose, and skin...
  56. ncbi Any benefits of probiotics in allergic disorders?
    Oner Ozdemir
    Division of Allergy Immunology, Department of Pediatrics, Private SEMA Research and Training Hospital, Istanbul, Turkey
    Allergy Asthma Proc 31:103-11. 2010
    ..Literature data for food allergy/hypersensitivity and asthma are not adequate for this guaranteed conclusion; however, clinical benefit of probiotic therapy ..
  57. ncbi Molecular diagnosis in allergy
    J Sastre
    Allergy Department, Fundacion Jimenez Diaz, Madrid, Spain
    Clin Exp Allergy 40:1442-60. 2010
    ..Nevertheless, all in vitro tests should be evaluated together with the clinical history, because allergen sensitization does not necessarily imply clinical responsiveness...
  58. ncbi Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria
    I Tillie-Leblond
    Dept of Pneumology, University of Lille, Lille, France
    Eur Respir J 37:640-7. 2011
    Metalworking fluids (MWF) are responsible for hypersensitivity pneumonitis (HP)...
  59. pmc Health-related quality of life among adolescents with allergy-like conditions - with emphasis on food hypersensitivity
    Birgitta Marklund
    Centre for Allergy Research, Karolinska Institutet, S 171 77 Solna, Sweden
    Health Qual Life Outcomes 2:65. 2004
    ..Furthermore, studies on food hypersensitivity and quality of life are scarce...
  60. ncbi Fetal and early postnatal life roots of asthma
    Giuseppina De Luca
    Department of Paediatrics, Policlinico GB Rossi, University of Verona, Piazzale L Scuro, Verona, Italy
    J Matern Fetal Neonatal Med 23:80-3. 2010
    ..Since some environmental triggers can be easily avoided and some protective factors can be easily implemented all efforts should be made to prevent intrauterine insults and early sensitization...
  61. pmc Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood
    Suzanne Havstad
    Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
    J Allergy Clin Immunol 128:880-885.e4. 2011
    ..No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE...
  62. ncbi Impacts of climate change on aeroallergens: past and future
    P J Beggs
    Department of Physical Geography, Division of Environmental and Life Sciences, Macquarie University, NSW 2109, Australia
    Clin Exp Allergy 34:1507-13. 2004
    ..It is important that public health authorities and allergy practitioners be aware of these changes in the environment, and that research scientists embrace the challenges that face further work in this area...
  63. ncbi Clinical effects of immunotherapy with genetically modified recombinant birch pollen Bet v 1 derivatives
    A Purohit
    Service de Pneumologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Clin Exp Allergy 38:1514-25. 2008
    ..Birch pollen and pollen from related trees of the Fagales order are a major cause of allergic rhinitis, conjunctivitis, and asthma through the spring season in northern and central Europe...
  64. ncbi Advances in mechanisms of asthma, allergy, and immunology in 2011
    Joshua A Boyce
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 129:335-41. 2012
    ..Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review...
  65. ncbi Prevalence of sensitivity to cockroach allergens and IgE cross-reactivity between cockroach and house dust mite allergens in Chinese patients with allergic rhinitis and asthma
    Bao Qing Sun
    State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong 510120, China
    Chin Med J (Engl) 123:3540-4. 2010
    ..The aim of this study was to investigate the cockroach prevalence in mainland of China and the cross-reactivity of IgE between cockroach and house dust mite allergen in Chinese patients...
  66. ncbi Different allergenic activity of grass pollen allergens revealed by skin testing
    K Westritschnig
    Medical University of Vienna, Austria
    Eur J Clin Invest 38:260-7. 2008
    ....
  67. ncbi RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents
    Daigen Xu
    Department of Inflammation Discovery, Hoffmann La Roche, 340 Kingsland Street, Nutley, NJ 07110, USA
    J Pharmacol Exp Ther 341:90-103. 2012
    ..RN486), in vitro and in rodent models of immune hypersensitivity and arthritis...
  68. ncbi Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections
    Gabriela Senti
    Clinical Trials Center, University Hospital Zurich, Zurich, Switzerland
    J Allergy Clin Immunol 129:1290-6. 2012
    ..Subcutaneous allergen-specific immunotherapy frequently causes allergic side effects and requires 30 to 80 injections over 3 to 5 years...
  69. pmc Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona
    Janet Rothers
    Arizona Respiratory Center, Department of Pediatrics, University of Arizona, Tucson, Ariz 85724, USA
    J Allergy Clin Immunol 128:1093-9.e1-5. 2011
    ..The association between vitamin D status at birth and childhood allergic outcomes is uncertain. The desert climate of Tucson offers a unique setting for studying the health effects of higher exposure to vitamin D...
  70. pmc T cell homing to epithelial barriers in allergic disease
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Nat Med 18:705-15. 2012
    ..Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases...
  71. pmc The indoor air and asthma: the role of cat allergens
    Libby A Kelly
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Curr Opin Pulm Med 18:29-34. 2012
    ..The objective is to discuss recent progress in our understanding of the role of the indoor environment in asthma, focusing on the special role of cat allergens...
  72. pmc The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis
    Jouni J K Jaakkola
    Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, United Kingdom
    Environ Health Perspect 116:845-53. 2008
    ..Phthalates from polyvinyl chloride (PVC) plastics may have adverse effects on airways and immunologic systems, but the evidence has not been reviewed systematically...
  73. ncbi Antioxidants and allergic disease: a case of too little or too much?
    K Allan
    Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen, UK
    Clin Exp Allergy 40:370-80. 2010
    ..However, the exact nature of the relationships and the potential for therapeutic intervention remain unclear...
  74. pmc Epidemiology and disease burden from allergic disease in Scotland: analyses of national databases
    C Anandan
    Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9DX, UK
    J R Soc Med 102:431-42. 2009
    ..We sought to: (1) describe the incidence, prevalence and outcome of allergic disorders; (2) estimate healthcare burden and costs; and (3) investigate ethnic variations in the epidemiology and outcomes from allergic disorders in Scotland...
  75. ncbi High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes
    Brett J Manley
    Department of Newborn Research, Royal Women s Hospital, 20 Flemington Rd, Parkville, Victoria 3052, Australia
    Pediatrics 128:e71-7. 2011
    ..Docosahexaenoic acid (DHA) has been associated with downregulation of inflammatory responses...
  76. ncbi Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
    ..The role of exposure to air pollution in the development of allergic sensitization remains unclear...
  77. ncbi The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis
    Hans Jorg Buhring
    Department of Internal Medicine II, Division of Hematology, Immunology and Oncology, University of Tubingen, Tubingen, Germany
    Int Arch Allergy Immunol 133:317-29. 2004
    ..In the present article, we review the current knowledge of CD203c with special regard to its tissue distribution and regulation in basophil activation. In addition, we discuss the application of CD203c in allergy diagnosis...
  78. ncbi Cockroach induces inflammatory responses through protease-dependent pathways
    Kota Wada
    Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 155:135-41. 2011
    ..This review focuses on the effects of cockroach on various inflammatory cells, including eosinophils, epithelial cells, fibroblasts, dendritic cells, and T cells, in allergic reactions...
  79. ncbi Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny
    Meri K Tulic
    Childhood Allergy and Immunology Research, School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 127:470-478.e1. 2011
    ..Microbial products are of central interest in the modulation of allergic propensity...
  80. ncbi Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens
    Elisabeth Roesler
    Department of Molecular Biology, Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, Salzburg, Austria
    J Allergy Clin Immunol 124:1070-7.e1-11. 2009
    ..mRNAs encoding allergen molecules represent an attractive tool for preventive vaccination because of the inherent safety features of this vaccine type...
  81. pmc Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation
    Cong Jin
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27514, USA
    J Clin Invest 121:941-55. 2011
    ..These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice...
  82. pmc Prediagnostic plasma IgE levels and risk of adult glioma in four prospective cohort studies
    Federico C F Calboli
    Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK
    J Natl Cancer Inst 103:1588-95. 2011
    ..An inverse association between serum IgE and risk of glioma was reported in a large case-control study, but reverse causality and treatment effects remain potential explanations for those findings...
  83. ncbi A strain of Lactobacillus casei inhibits the effector phase of immune inflammation
    Cecile Schiffer
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, 75015 Paris, France
    J Immunol 187:2646-55. 2011
    ..They might, therefore, prevent inflammation in patients who have already synthesized specific IgE or autoantibodies...
  84. ncbi Anti-interleukin-5 antibody therapy in asthma and allergies
    Jonathan Corren
    Allergy Medical Clinic, Los Angeles, California, USA
    Curr Opin Allergy Clin Immunol 11:565-70. 2011
    ....
  85. pmc Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody
    Mi Li
    Macromolecular Crystallography Laboratory, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 283:22806-14. 2008
    ..We have now identified key residues involved in IgE antibody binding; this information will be useful for the design of vaccines for immunotherapy...
  86. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012
    ..Though one might expect periostin to play a deleterious role in asthma pathogenesis, to date its biological role in the airway is unknown...
  87. ncbi Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice
    Vincent Dioszeghy
    DBV Technologies, Pépinière Paris Santé Cochin, 75014 Paris, France
    J Immunol 186:5629-37. 2011
    ..Besides providing new insights into skin function in the presence of allergens, this study indicates that the skin might have a tolerogenic role, at least when kept intact...
  88. ncbi BLT2 Is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines
    Kyung Jin Cho
    College of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Immunol 185:6329-37. 2010
    ..Taken together, our results suggest that the BLT2-Nox1-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs, thus contributing to allergic response...
  89. pmc Helicobacter pylori colonization is inversely associated with childhood asthma
    Yu Chen
    Department of Environmental Medicine, School of Medicine, New York University, New York, New York 10016, USA
    J Infect Dis 198:553-60. 2008
    ..Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma...
  90. pmc Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies
    Adnan Custovic
    University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    J Allergy Clin Immunol 127:390-397.e1-9. 2011
    ..Variation in the Toll-like receptor 2 gene (TLR2/-16934) is associated with allergic diseases among farmers' children but not among children not living on farms...
  91. ncbi Innate immunity and allergy in the skin
    Martin Metz
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Curr Opin Immunol 21:687-93. 2009
    ..Mast cells, the most important effector cells in immediate hypersensitivity type allergic reactions, effectively combat bacterial infections, for example by releasing antimicrobial ..
  92. ncbi New developments in FcepsilonRI regulation, function and inhibition
    Stefan Kraft
    Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 945, 71 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA
    Nat Rev Immunol 7:365-78. 2007
    ....
  93. ncbi Establishing the sequential progression of multiple allergic diagnoses in a UK birth cohort using the General Practice Research Database
    Y S Punekar
    Schering Plough Ltd, Welwyn Garden City, UK
    Clin Exp Allergy 39:1889-95. 2009
    ..There is considerable international interest in understanding the sequential progression of multiple allergic conditions (also sometimes known as 'the allergic march')...
  94. ncbi Time trends in asthma and wheeze in Swedish children 1996-2006: prevalence and risk factors by sex
    Anders Bjerg
    The OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    Allergy 65:48-55. 2010
    ..We sought to investigate sex-specific trends in wheeze, asthma, allergic conditions, allergic sensitization and risk factors for wheeze...
  95. pmc In vivo-to-in silico iterations to investigate aeroallergen-host interactions
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e2426. 2008
    ....
  96. ncbi Characterization and comparison of commercially available mite extracts for in vivo diagnosis
    B Brunetto
    Center for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanita, Rome
    Allergy 65:184-90. 2010
    ..This study aimed at evaluating commercially available mite extracts for in vivo diagnosis from eight manufacturers...
  97. ncbi Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy
    M Mertens
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Clin Exp Allergy 40:1333-45. 2010
    ..This phenomenon is mainly caused by specific IgE (sIgE) against cross-reactive carbohydrate determinants (CCD). Whether or not these antibodies can induce clinical symptoms is a longstanding debate...
  98. ncbi Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy
    Audrey H Poon
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Am J Respir Crit Care Med 170:967-73. 2004
    ..These results identify VDR variants as genetic risk factors for asthma/atopy and implicate a non-human leukocyte antigen immunoregulatory molecule in the pathogenesis of asthma and atopy...
  99. ncbi Microarrayed allergen molecules for the diagnosis of allergic diseases
    Adriano Mari
    Center for Molecular Allergology, IDI IRCCS, Via dei Monti di Creta 104, Rome, Italy
    Curr Allergy Asthma Rep 10:357-64. 2010
    ....
  100. pmc Histological features of pseudotumor-like tissues from metal-on-metal hips
    Pat Campbell
    J Vernon Luck Sr MD Orthopaedic Research Center, Orthopaedic Hospital UCLA, 2400 S Flower Street, Los Angeles, CA 90007, USA
    Clin Orthop Relat Res 468:2321-7. 2010
    ..The cause of these reactions is not well understood but could be due to excessive wear, or metal hypersensitivity or an as-yet unknown cause...
  101. ncbi Role of innate immunity in the development of allergy and asthma
    Peter D Sly
    Queensland Children s Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia
    Curr Opin Allergy Clin Immunol 11:127-31. 2011
    ..The purpose of this review is to examine the role of innate immunity in the lungs in the development of allergy and asthma...

Research Grants76

  1. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..of the DDR, such as ATM, BRCA1 and p53 are known to cause a predisposition to cancer development as well as hypersensitivity to ultraviolet and ionizing radiation [1-3]...
  2. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..health concerns, and mast cells and possibly basophils are the major effector cells of IgE-mediated immediate hypersensitivity in humans...
  3. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..However, ICSBP-deficient myeloid progenitor cells exhibit resistance to apoptosis, hypersensitivity to hematopoietic cytokines, and the tendency to accumulate additional genetic lesions...
  4. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..a high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid tumors, and cellular hypersensitivity to cross-linking agents...
  5. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid tumors, and cellular hypersensitivity to cross-linking agents...
  6. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..female veterans that serve in OEF/OIF, studies have shown that symptoms of abdominal pain are due to visceral hypersensitivity characterized by increased awareness of visceral stimuli in Gulf War Veterans (GWV) and that symptoms are ..
  7. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..The in vitro work will be extended by using DNase I hypersensitivity, chromatin immunoprecipitation, and DNA affinity purification assays to study the role of chromatin structure ..
  8. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..mechanistic findings in rats into pharmacologic strategies for preventing or reversing carotid chemoreflex hypersensitivity, thereby ameliorating the cardiovascular consequences of OSA and, if our hypothesis is correct, perhaps even ..
  9. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..Some likely mechanisms of hepatotoxicity include proinflammatory cytokine production mitochondrial toxicity, hypersensitivity reactions, steatosis and insulin resistance, immune reconstitution in HCV or HBV co-infected patients, and ..
  10. Immune Development: Role of Milk Cell Transfer and Recipient Gender
    Ameae M Walker; Fiscal Year: 2013
    ..transferred, we examined whether sensitizing dams with an antigen that elicits a T cell-mediated delayed-type-hypersensitivity (DTH) response, would result in sensitization of adult offspring. This was not apparent...
  11. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..pristane-induced arthritis, and experimental autoimmune diabetes as well as prevent delayed-type hypersensitivity in rats. Based on the fact that the small molecule Kv1...
  12. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..Additionally, novel factors will be sought by unbiased approaches of DNAse1 footprinting and hypersensitivity assays. The therapeutic implications of the ability to reactivate hepatic Epo synthesis are substantial...
  13. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..for atherosclerosis, and sex differences in cardiovascular disease (CVD), autoimmune disease and airway hypersensitivity have been reported...
  14. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..3 blockers prevent and/or treat disease in rat models of MS, T1DM, RA, contact dermatitis, delayed type hypersensitivity (DTH) and bone resorption associated with periodontitis...
  15. Epigenetic Regulation Of Sex-dependent Liver Cancer
    Arlin B Rogers; Fiscal Year: 2012
    ..Because of this, we hypothesize that masculine Stat5b-dependent epigenetic remodeling invokes chromatin hypersensitivity to tumor-promoting proinflammatory cytokines...
  16. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    ..a high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid tumors, and cellular hypersensitivity to cross-linking agents...
  17. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..after the uteroplacental arteries "open" towards the end of the first trimester of pregnancy, the oxygen hypersensitivity of cells derived from PE placentas may cause them to turnover at an accelerated rate and shed cell contents ..
  18. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..So the hypersensitivity of the ssk1 mutant to triazoles appears to be very specific...
  19. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ..between colonic and bladder sensory pathways, and to identify mediators that regulate bladder sensory hypersensitivity as a result of colitis...
  20. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy, predisposing individuals to a spectrum of disorders, allergic rhinitis, atopic dermatitis, and allergic asthma...
  21. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..Our work will be critical for a better understanding nociceptor pathways and processes underlying hypersensitivity pain and may ultimately lead to novel targets for its treatment.
  22. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..Characterization of these proinflammatory pathways allows for therapeutic approaches based on targeted intervention. ..
  23. HEPATIC DEGRADATION OF CYTOCHROME P450 ENZYMES
    Maria Almira Correia; Fiscal Year: 2013
    ..to the outer plasma membrane, whereupon it is recognized by the immune surveillance system, engendering pathogenic autoantibodies clinically associated with alcoholic liver disease, drug-induced hepatitis, and hypersensitivity syndromes.
  24. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..Chromatin remodeling at the TSLPR locus will be assessed in DCs by chromatin immunoprecipitation and DNase hypersensitivity assays...
  25. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..of persistent pain, findings that (1) sleep restriction increases susceptibility to hind paw mechanical hypersensitivity in both controls and animals with sciatic inflammatory neuritis and (2) repeated social defeat, a preclinical ..
  26. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2013
    ..analogs (ShK-186) suppresses TEM cell enlargement and motility in inflamed tissues, inhibits delayed-type hypersensitivity, and effectively treats chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE;a model of MS) ..
  27. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..HPS patient hypoxia combined with the hypersensitivity of infected ECs to VEGF, provides a means for amplifying HIF1? -VEGF responses that contribute to pulmonary ..
  28. Checkpoints of TNF Gene Regulation
    Anne Goldfeld; Fiscal Year: 2013
    ..locus, where conserved functional genetic regions are associated with cell type- and stimulus-specific DNase hypersensitivity sites (HSSs), intrachromosomal interactions, and interactions with the nuclear matrix...
  29. Epigenetic regulation in neuropathic pain
    Zhonghui Guan; Fiscal Year: 2013
    ..and transcription factors, including ATF, is greatly reduced, we found that nerve injury-induced mechanical hypersensitivity, key behavior readout of neuropathic pain, was very short-lived...
  30. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..have shown that Gulf War Veterans (GWV) who develop symptoms of abdominal pain and diarrhea exhibit visceral hypersensitivity characterized by increased awareness of visceral stimuli, similar to patients with functional GI disorders ..
  31. Functional Consequence of Macrolide Resistance Mutations in T. pallidum
    Sheila A Lukehart; Fiscal Year: 2012
    ..If these mutations are found to be common and are shown to cause treatment failure, physicians will be advised not to use azithromycin for treating patients with syphilis. ..
  32. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..mycobacterial and schistosomal antigens, respectively elicit polarized Th1 (type-1) and Th2 (type-2) hypersensitivity-type GR formation...
  33. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..of immunosuppressive drugs after transplantation; b) to determine whether serial trans-vivo Delayed Type Hypersensitivity (tvDTH) and mixed lymphocyte reaction (MLR) analysis of tolerance on indirect and direct pathways of ..
  34. Estrogen and TMJ Pain
    Phillip R Kramer; Fiscal Year: 2013
    ..Consistent with these results, estrogen reduces TMJ hypersensitivity in proestrus rats, when estrogen concentrations are highest...
  35. Epigenetic Modifications of BDNF and trkB Genes Underlie Pain Plasticity
    John David Sweatt; Fiscal Year: 2013
    ..Much like memory formation in the hippocampus, central sensitization in the spinal cord produces pain hypersensitivity that is uncoupled from noxious input...
  36. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ..that release of substance P in the rostral ventromedial medulla (RVM) mediates the thermal and mechanical hypersensitivity that follow inflammatory injury of the hindpaw...
  37. ATF2 in DNA damage response.
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..recruitment of Mre11 and NBS1 to the repair foci and attenuates the S-phase checkpoint, and results in hypersensitivity to IR. Furthermore, ATF2 is also required for the activation of ATM, and consequently of Chk1 and Chk2...
  38. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..Neurophysiology of ENS-spinal afferent-mast cell interactions is basic for understanding visceral hypersensitivity and emerging recognition that functional abdominal pain involves co-morbidity of intestinal hypersensitivity ..
  39. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..of early megakaryocyte- erythroid (MegE) progenitors, (2) cytokine independent growth and (3) cell-intrinsic hypersensitivity to serum and the cytokine GM-CSF in committed GM progenitors...
  40. Developing and Improving the UAB Gnotobiotic Facility.
    SAMUEL CORBIN CARTNER; Fiscal Year: 2013
    ..Most recently, evidence has begun to appear that microbiota also affect development of hypersensitivity diseases such as asthma...
  41. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..severity (edema, T cell and neutrophil infiltration, and expression of IL1 , IFN , and TNF ) of delayed type hypersensitivity evoked in the ears with dinitrofluorobenzene. Transgene effects on inflammation are thus limited to the bowel...
  42. Etanercept: a Mechanistic Probe of Central Mu-Opioid Dysregulation in Pain States
    ALAN RODNEY PROSSIN; Fiscal Year: 2013
    ..e. TNF-alpha, IL-1beta) are implicated in hypernociceptive states (i.e. pain hypersensitivity in FM) in humans and animal models. Pro- inflammatory cytokine antagonists (i.e...
  43. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2012
    ..This transcriptional effect of chronic stress mediators results in smooth muscle hypersensitivity to ACh and faster transit in the colon;and 2) The cellular interactions between the stress mediators and ..
  44. Regulation of TRPV1 and Nociceptor Sensitization by the Complement System
    Yuriy M Usachev; Fiscal Year: 2013
    ..In spite of this strong evidence implicating the complement system in the development of pain hypersensitivity, the underlying mechanisms are not understood...
  45. Integrin-dependent mechanism of T cell-mediated pulmonary fibrosis
    Irina G Luzina; Fiscal Year: 2012
    ..For example, scarring of the lungs occurs in such diseases as scleroderma, rheumatoid arthritis, hypersensitivity pneumonitis, sarcoidosis, and idiopathic pulmonary fibrosis...
  46. Sex Hormones and Visceral Hypersensitivity
    Elie D Al-Chaer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pain and visceral hypersensitivity are the main characteristics of irritable bowel syndrome (IBS), an extremely common disorder affecting up to 15% of the US population with a major socioeconomic ..
  47. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    ..In Specific Aim 2A, we will determine colocalization of the CNS EDC to open chromatin using DNasel hypersensitivity assays in mouse keratinocytes and barrier deficient mouse models...
  48. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..animal model of comorbid pain conditions in which TMD and subchronic stress are combined to produce colonic hypersensitivity arising from otherwise healthy tissue...
  49. A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..the anti-EMP2 IgG1 and to induce a distinct allergic reaction against the tumor consisting of a local Type I hypersensitivity reaction that leads to acute inflammation and eventually cancer cell destruction in the tumor ..
  50. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    ..expressing pro-enkephalin, GAD, the glycine receptor, and anti inflammatory proteins to treat VZV-induced hypersensitivity in the model, all of which have been shown to reduce pain in other systems...
  51. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2013
    ..HS4, HS5, HS11/12) marked by the convergence of three indicators of cis-regulatory function: DNase I hypersensitivity, DNA hypomethylation and sequence conservation...
  52. The role of TNF-Alpha in cutaneous integrity
    Victoria P Werth; Fiscal Year: 2013
    ..Here, we will use mega-DNase I hypersensitivity analysis (MDHA) of the endogenous TNFa gene to discover distal cis-acting control sequences...
  53. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2012
    ..The basis of their hypersensitivity will be probed with a number of experimental tests, and a major goal is to identify a subset of the mutants ..
  54. FANCD2 interaction with mismatch repair proteins and MCM2-7
    Gary M Kupfer; Fiscal Year: 2013
    ..by applicant): The Fanconi anemia (FA) phenotype on a cellular level is marked by genomic instability and hypersensitivity to DNA damage...
  55. Genetic Analysis of Ataxia-telangiectasia
    DAVID WASSARMAN; Fiscal Year: 2012
    ..Cells derived from A-T patients exhibit chromosomal instability and hypersensitivity to DNA damaging agents...
  56. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..These supernumerary teeth result from hypersensitivity of the odontogenic epithelium or mesenchyme to FGF signaling...
  57. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..Increased excitability is caused by changes in ion channel expression that result in visceral hypersensitivity in female rats...
  58. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..by which inflammation shapes neuronal plasticity to cause dysfunction and disease, and may lead to new therapies to control neuronal hypersensitivity, inflammation, pain and functional disturbances of the gastrointestinal tract.
  59. Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary Mortality
    ELLEN AURA EISEN; Fiscal Year: 2013
    ..In April 2010, the United Autoworkers again petitioned OSHA for a MWF standard on the basis of asthma, hypersensitivity pneumonitis and cancer, underscoring the significance and timeliness of this application...
  60. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2013
    ..Moreover, IP6K1 knockout mice display insulin hypersensitivity and fail to gain weight on a high fat diet...
  61. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..This would be predicted to result in susceptibility to pulmonary infections and hypersensitivity to inhaled allergens...
  62. Identifying disease-related functional regulatory variants in open chromatin
    Karen L Mohlke; Fiscal Year: 2010
    ..Successful genome-wide experimental approaches to identify open chromatin include DNase hypersensitivity (DHS), formaldehyde-assisted identification of regulatory elements (FAIRE), markers of histone modification, ..
  63. NEMATODE-INDUCED PULMONARY GRANULOMA FORMATION
    STEPHEN KAYES; Fiscal Year: 1991
    ..All attempts to transfer granulomatous hypersensitivity from infected mice to naive recipients using spleen cells or hyperimmune serum from infected mice have failed...
  64. Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy
    Sheng Xing Ma; Fiscal Year: 2010
    ..Hyperalgesia and hypersensitivity to temperature/ pressure in ZDF rats are improved by low-frequency electroacupuncture (EA) stimulation of ..
  65. Is small intestinal bacterial overgrowth associated with functional dyspepsia?
    Henry C Lin; Fiscal Year: 2010
    ..Objective: We will determine the prevalence and association of SIBO, abnormal interdigestive motility, and hypersensitivity in FD...
  66. Potential Therapeutic Applications of Ecto-Nucleotidases in Lithium-induced NDI
    Bellamkonda K Kishore; Fiscal Year: 2010
    ..this context, we discovered that increased production of renal PGE2 in Li-induced NDI may be related to the hypersensitivity of P2Y2 receptor, an extracellular nucleotide (ATP/UTP) receptor, in the medullary collecting duct (mCD)...
  67. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ..However, hypersensitivity mediated by SMX limits its use...
  68. HYPOTHERMIA AND TRAUMA
    Larry Jenkins; Fiscal Year: 2000
    ..Our studies also show hippocampal hypersensitivity to posttraumatic forebrain ischemia for 1 to 24 hours after FP-TB1, which is mediated, in part, by ..
  69. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ..Immunogenic inflammation associated with delayed hypersensitivity reactions can grossly distort the visual axis resulting in blindness...
  70. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    Peanut allergy is one of the most serious of the immediate hypersensitivity reactions to foods in terms of persistence and severity of the reaction and appears to be a growing problem...
  71. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..spontaneously oxidize to reactive nitroso metabolites, which, in the case of SMX, can trigger delayed-type hypersensitivity reactions...
  72. METABOLIC BASIS OF SULFONAMIDE TOXICITY IN AIDS PATIENTS
    CRAIG SVENSSON; Fiscal Year: 1999
    The use of sulfamethoxazole-trimethoprim (TMP-SMX) is associated with idiosyncratic/hypersensitivity reactions which significantly limit its use, and the frequency of these reactions is increased in HIV infected patients...
  73. Symposium: Progress in Fanconi Anemia Research
    Grover Bagby; Fiscal Year: 2001
    ..Cells from FA patients exhibit hypersensitivity to alkylating agents such as mitomycin C (MMC) and diepoxybutane (DEB) and this hypersensitivity is currently ..
  74. Opioid-Induced Immune Alterations: Gender Differences
    DONALD LYSLE; Fiscal Year: 2006
    ..Specific Aim I provides a pharmacological analysis of the effects of morphine on the contact hypersensitivity (CHS) response in males and females, with an emphasis on clinical outcome measures (i.e...
  75. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..We postulate that these sequential responses reflect adaptive changes in tumors whereby hypersensitivity to both the proliferative and pro-apoptotic effects of estradiol occurs in response to up-regulation of ..
  76. Estrogen Withdrawal and Dural Mast Cells: Implication for Menstrual Migraine
    Dan Levy; Fiscal Year: 2010
    ..enhancement in meningeal nociceptor activity subsequently facilitates the development of delayed pericranial hypersensitivity (a condition associated with migraine pain)...