pemphigus

Summary

Summary: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.

Top Publications

  1. pmc Desmoglein as a target in skin disease and beyond
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 132:776-84. 2012
  2. pmc Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism
    Emmanuella Delva
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Department of Cell Biology, Emory University, Atlanta, GA 30332, USA
    J Biol Chem 283:18303-13. 2008
  3. pmc Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation
    Masataka Saito
    Departments of Cell Biology, Dermatology and the Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e50696. 2012
  4. pmc p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris
    Xuming Mao
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:1283-91. 2011
  5. pmc Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Clin Invest 122:3781-90. 2012
  6. ncbi Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens
    Alex I Chernyavsky
    Department of Dermatology, University of California, Davis, California 95816, USA
    J Biol Chem 282:13804-12. 2007
  7. ncbi Genetic evidence for a novel human desmosomal cadherin, desmoglein 4
    Neil V Whittock
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    J Invest Dermatol 120:523-30. 2003
  8. ncbi Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies
    Catharine C Calkins
    Departments of Dermatology and Cell Biology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Biol Chem 281:7623-34. 2006
  9. ncbi Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 170:2170-8. 2003
  10. pmc A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris
    R Caldelari
    Institute of Animal Pathology, University of Bern, , CH-3012 Bern, Switzerland
    J Cell Biol 153:823-34. 2001

Detail Information

Publications327 found, 100 shown here

  1. pmc Desmoglein as a target in skin disease and beyond
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 132:776-84. 2012
    ..The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between ..
  2. pmc Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism
    Emmanuella Delva
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Department of Cell Biology, Emory University, Atlanta, GA 30332, USA
    J Biol Chem 283:18303-13. 2008
    b>Pemphigus vulgaris (PV) is a life-threatening autoimmune disease characterized by oral mucosal erosions and epidermal blistering. The autoantibodies generated target the desmosomal cadherin desmoglein-3 (Dsg3)...
  3. pmc Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation
    Masataka Saito
    Departments of Cell Biology, Dermatology and the Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e50696. 2012
    b>Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease caused by autoantibodies directed against the desmosomal cadherin desmoglein-3 (Dsg3)...
  4. pmc p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris
    Xuming Mao
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:1283-91. 2011
    b>Pemphigus vulgaris (PV) is a potentially fatal blistering disease characterized by autoantibodies against the desmosomal adhesion protein desmoglein (Dsg) 3...
  5. pmc Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Clin Invest 122:3781-90. 2012
    b>Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion...
  6. ncbi Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens
    Alex I Chernyavsky
    Department of Dermatology, University of California, Davis, California 95816, USA
    J Biol Chem 282:13804-12. 2007
    Although it is accepted that pemphigus antibody binding to keratinocytes (KCs) evokes an array of intracellular biochemical events resulting in cell detachment and death, the triggering events remain obscure...
  7. ncbi Genetic evidence for a novel human desmosomal cadherin, desmoglein 4
    Neil V Whittock
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    J Invest Dermatol 120:523-30. 2003
    ..We have demonstrated using RT-PCR on multiple tissue cDNA samples that desmoglein 4 has very specific tissue expression in salivary gland, testis, prostate, and skin...
  8. ncbi Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies
    Catharine C Calkins
    Departments of Dermatology and Cell Biology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Biol Chem 281:7623-34. 2006
    ..b>Pemphigus vulgaris (PV) is an autoimmune disorder in which antibodies are directed against the desmosomal adhesion ..
  9. ncbi Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 170:2170-8. 2003
    b>Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease that is caused by IgG autoantibodies against the cadherin-type adhesion molecule desmoglein (Dsg)3...
  10. pmc A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris
    R Caldelari
    Institute of Animal Pathology, University of Bern, , CH-3012 Bern, Switzerland
    J Cell Biol 153:823-34. 2001
    In pemphigus vulgaris (PV), autoantibody binding to desmoglein (Dsg) 3 induces loss of intercellular adhesion in skin and mucous membranes...
  11. ncbi Paraneoplastic pemphigus associated with Castleman tumor: a commonly reported subtype of paraneoplastic pemphigus in China
    Jing Wang
    Department of Dermatology, Peking University First Hospital, Beijing, China
    Arch Dermatol 141:1285-93. 2005
    Castleman tumor, a rare lymphoproliferative disorder, is one of the associated tumors in paraneoplastic pemphigus. We analyzed the characteristics of a group of patients with Castleman tumor to clearly understand and to improve the ..
  12. pmc Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity
    V T Nguyen
    Department of Dermatology, University of California at Davis, Sacramento, California, USA
    Am J Pathol 157:1377-91. 2000
    b>Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease...
  13. ncbi Targeting pemphigus autoantibodies through their heavy-chain variable region genes
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 127:1681-91. 2007
    b>Pemphigus vulgaris (PV) is a potentially fatal blistering disease characterized by autoantibodies against cell surface adhesion proteins desmoglein (Dsg) 3 and Dsg1...
  14. pmc Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:888-99. 2005
    b>Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 (Dsg3) and Dsg1...
  15. ncbi Current therapy of the pemphigus group
    Michael Kasperkiewicz
    Department of Dermatology, University of Lubeck, Germany
    Clin Dermatol 30:84-94. 2012
    Treatment of pemphigus patients is still challenging and, in some cases, conventional therapy with systemic corticosteroids in combination with adjuvant corticosteroid-sparing immunosuppressive drugs is not sufficient to induce clinical ..
  16. ncbi Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations
    Ilana Kaplan
    Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petach Tiqva, Israel
    Oral Oncol 40:553-62. 2004
    The review included 163 cases of paraneoplastic pemphigus (PNP) reported between 1990 and 2003, including a new unique case of PNP associated with occult breast cancer and an ovarian cyst of borderline malignancy...
  17. pmc Pemphigus autoimmunity: hypotheses and realities
    Sergei A Grando
    Department of Dermatology, University of California, Irvine, CA 92697, USA
    Autoimmunity 45:7-35. 2012
    The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids...
  18. ncbi Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis
    Alex I Chernyavsky
    Department of Dermatology, University of California, Irvine, California 92697, USA
    J Biol Chem 283:3401-8. 2008
    ..The IgG autoantibodies produced in patients with the immunoblistering skin disease pemphigus vulgaris (PV) can induce keratinocyte (KC) dyshesion (acantholysis) via mechanisms that involve signaling ..
  19. pmc Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study
    S M Langan
    Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    BMJ 337:a180. 2008
    To determine the incidence of and mortality from bullous pemphigoid and pemphigus vulgaris in the United Kingdom.
  20. ncbi Treatment of severe pemphigus with rituximab: report of 12 cases and a review of the literature
    Giuseppe Cianchini
    Division of Dermatology, Istituto Dermopatico dell Immacolata, IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy
    Arch Dermatol 143:1033-8. 2007
    Treatment of pemphigus vulgaris can be challenging. Systemic steroids associated with other immunosuppressant agents are the mainstay of therapy and have dramatically reduced morbidity and mortality from pemphigus vulgaris...
  21. ncbi Epitope spreading is rarely found in pemphigus vulgaris by large-scale longitudinal study using desmoglein 2-based swapped molecules
    Bungo Ohyama
    Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan
    J Invest Dermatol 132:1158-68. 2012
    Epitope spreading is involved in inducing and maintaining self-reactivity. Epitope spreading in pemphigus vulgaris (PV), caused by IgG autoantibodies to desmoglein 3 (Dsg3) and Dsg1, was previously analyzed using Dsg3/Dsg1 extracellular ..
  22. ncbi Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris
    Christian Veldman
    Department of Dermatology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 172:6468-75. 2004
    b>Pemphigus vulgaris (PV) is a severe autoimmune bullous skin disorder and is primarily associated with circulating autoantibodies against desmoglein 3 (Dsg3) that are presumably regulated by Th cells...
  23. pmc p38MAPK inhibition prevents disease in pemphigus vulgaris mice
    Paula Berkowitz
    Department of Dermatology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7287, USA
    Proc Natl Acad Sci U S A 103:12855-60. 2006
    b>Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease characterized by detachment of keratinocytes (acantholysis)...
  24. pmc Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction
    Jens Waschke
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    J Clin Invest 115:3157-65. 2005
    ..desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV)...
  25. ncbi Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction
    Wolfgang Moritz Heupel
    Department of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    J Immunol 181:1825-34. 2008
    The autoimmune blistering skin disease pemphigus is caused by autoantibodies against keratinocyte surface Ags...
  26. ncbi Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia
    G J Anhalt
    Department of Dermatology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205
    N Engl J Med 323:1729-35. 1990
    ..Immunofluorescence testing revealed atypical pemphigus-like autoantibodies in perilesional epithelium and serum from all five patients...
  27. ncbi In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris
    Ken Ishii
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 124:939-46. 2005
    Patients with pemphigus vulgaris (PV) have circulating anti-desmoglein (Dsg) 3 immunoglobulin G (IgG) autoantibodies that induce blister formation...
  28. ncbi Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem)
    T B Rosatelli
    Dermatology, Department of Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049 900, Ribeirao Preto, SP, Brazil
    Br J Dermatol 152:650-7. 2005
    b>Pemphigus foliaceus (PF) is an autoimmune blistering disease of unknown aetiology, which is endemic in Brazil. Although the pathogenesis of PF is still unknown, proteins of the contact system have been implicated.
  29. ncbi Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series
    Gilson Antonio Pereira Gonçalves
    Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    An Bras Dermatol 86:1109-12. 2011
    There are two main clinical subsets of pemphigus: pemphigus vulgaris and pemphigus foliaceus. Clinical and epidemiological changes related to both types of pemphigus have been observed in the last years.
  30. ncbi Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus
    T Hashimoto
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Arch Dermatol 137:735-8. 2001
    To examine the frequency of antidesmoglein 1 (Dsg1) and antidesmoglein 3 (Dsg3) IgA autoantibodies in IgA pemphigus.
  31. ncbi Incidence, mortality, and causes of death of patients with pemphigus in Taiwan: a nationwide population-based study
    Yu Huei Huang
    Department of Dermatology, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    J Invest Dermatol 132:92-7. 2012
    b>Pemphigus is a potentially life-threatening autoimmune blistering disease. However, little is known about the all-cause and cause-specific mortality among patients with pemphigus compared with the general population...
  32. ncbi Pathogenic human monoclonal antibody against desmoglein 3
    Shih Wei Yeh
    Department of Oral Medicine, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Clin Immunol 120:68-75. 2006
    b>Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3 (Dsg3), a 130-kDa epidermal cadherin protein...
  33. ncbi IgA pemphigus
    Daisuke Tsuruta
    Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Clin Dermatol 29:437-42. 2011
    b>Pemphigus is a life-threatening autoimmune blistering disease. Pemphigus is divided into 4 major types; pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, and IgA pemphigus...
  34. ncbi Constructing immunoprofiles to deconstruct disease complexity in pemphigus
    Animesh A Sinha
    Ralph and Rita Behling Professor and Chair of Dermatology, Department of Dermatology, University at Buffalo and Roswell Park Cancer Institute, Buffalo, NY, USA
    Autoimmunity 45:36-43. 2012
    The complex etiology of multifactorial diseases such as pemphigus vulgaris complicates mechanistic investigations and confounds current therapeutic approaches. Two major sources contribute to the overall complexity of disease...
  35. ncbi Immunolocalization of target autoantigens in IgA pemphigus
    N Ishii
    Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830 0011, Japan
    Clin Exp Dermatol 29:62-6. 2004
    IgA pemphigus is a rare autoimmune bullous disease characterized by IgA deposition at keratinocyte cell surfaces...
  36. ncbi Pemphigus herpetiformis: analysis of the autoantibody profile during the disease course with changes in the clinical phenotype
    S Lebeau
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Clin Exp Dermatol 35:366-72. 2010
    b>Pemphigus herpetiformis (PH) is a rare dapsone-responsive variant of pemphigus, characterized by annular and vesiculopustular cutaneous lesions...
  37. ncbi Randomized open comparative trial of dexamethasone-cyclophosphamide pulse and daily oral cyclophosphamide versus cyclophosphamide pulse and daily oral prednisolone in pemphigus vulgaris
    Pradeep K Sethy
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian J Dermatol Venereol Leprol 75:476-82. 2009
    In various case series, pulse therapy has shown good results in pemphigus vulgaris (PV), with long-term remissions.
  38. ncbi IVIg selectively and rapidly decreases circulating pathogenic autoantibodies in pemphigus vulgaris
    Jean Claude Bystryn
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA
    Autoimmunity 39:601-7. 2006
    Intraveneous immunoglobulin (IVIg) is increasingly used to treat pemphigus vulgaris (PV). The mechanism by which it does so is not known...
  39. pmc The extent of desmoglein 3 depletion in pemphigus vulgaris is dependent on Ca(2+)-induced differentiation: a role in suprabasal epidermal skin splitting?
    Volker Spindler
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Am J Pathol 179:1905-16. 2011
    b>Pemphigus vulgaris (PV) is an autoimmune disease of the skin and mucous membranes and is characterized by development of autoantibodies against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 and formation of intraepidermal ..
  40. ncbi IgG-induced clustering of desmogleins 1 and 3 in skin of patients with pemphigus fits with the desmoglein nonassembly depletion hypothesis
    D A M Oktarina
    Department of Dermatology, Centre for Blistering Diseases, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Br J Dermatol 165:552-62. 2011
    In pemphigus circulating IgG is present with the desmosomal cadherins desmoglein (Dsg) 1 and 3. In the epidermis of patients, this IgG deposits in a pattern that is often partly granular and does not reflect the normal Dsg distribution.
  41. ncbi Pemphigus: etiology, pathogenesis, and inducing or triggering factors: facts and controversies
    Vincenzo Ruocco
    Department of Dermatology, Second University of Naples, Via S Pansini, 5 80131 Naples, Italy
    Clin Dermatol 31:374-81. 2013
    b>Pemphigus includes a group of autoimmune bullous diseases with intraepithelial lesions involving the skin and Malpighian mucous membranes...
  42. ncbi Direct and indirect immunofluorescence
    Valeria Aoki
    Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil
    An Bras Dermatol 85:490-500. 2010
    ..It is a feasible laboratory method that requires experienced technicians and detects in situ and circulating immune deposits that may be involved in the pathogenesis of such skin diseases...
  43. ncbi Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine
    V T Nguyen
    Department of Dermatology, University of California at Davis, Sacramento, California 95817, USA
    J Biol Chem 275:29466-76. 2000
    Because pemphigus vulgaris (PV) IgGs adsorbed on the rDsg3-Ig-His baculoprotein induced blisters in neonatal mice, it was proposed that anti-desmoglein 3 (Dsg 3) autoantibody causes PV...
  44. pmc Mechanisms of mitochondrial damage in keratinocytes by pemphigus vulgaris antibodies
    Mina Kalantari-Dehaghi
    Department of Dermatology, University of California, Irvine, California 92697, USA
    J Biol Chem 288:16916-25. 2013
    The development of nonhormonal treatment of pemphigus vulgaris (PV) has been hampered by a lack of clear understanding of the mechanisms leading to keratinocyte (KC) detachment and death in pemphigus...
  45. pmc p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis
    Puneet S Jolly
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599 7287, USA
    J Biol Chem 285:8936-41. 2010
    b>Pemphigus vulgaris (PV) is an autoimmune blistering disease in which antibodies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis...
  46. pmc Autoimmunity to desmocollin 3 in pemphigus vulgaris
    Xuming Mao
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA
    Am J Pathol 177:2724-30. 2010
    b>Pemphigus vulgaris is a blistering disease associated with autoantibodies to the desmosomal adhesion protein, desmoglein 3...
  47. ncbi In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus
    Ken Ishii
    Department of Dermatology, Toho University, School of Medicine, Tokyo, Japan
    Methods Mol Biol 961:219-25. 2013
    Patients with pemphigus have circulating anti-desmoglein (Dsg) 1 and/or Dsg3 autoantibodies that induce blister formation on the skin and mucous membrane...
  48. ncbi A perspective of pemphigus from bedside and laboratory-bench
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Rev Allergy Immunol 33:57-66. 2007
    b>Pemphigus represents a distinct organ-specific acquired autoimmune disease characterized by intra-epidermal blistering, which is induced by autoantibodies against desmosomal cadherins, desmoglein 1 (Dsg1), and Dsg3...
  49. ncbi Mechanisms of desmosome assembly and disassembly
    Y Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Exp Dermatol 27:684-90. 2002
    ..The key implications for understanding desmosome dynamics from these findings are summarized in this review...
  50. ncbi New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
    Yasuo Kitajima
    Department of Dermatology, Kizawa Memorial Hospital, Professor Emeritus Gifu University School of Medicine, Minokamo City, Gifu, Japan
    Kaohsiung J Med Sci 29:1-13. 2013
    ..b>Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by anti-Dsg3 antibodies...
  51. ncbi Circulating pemphigus autoantibodies in healthy relatives of pemphigus patients: coincidental phenomenon with a risk of disease development?
    Jolanta Dorota Torzecka
    Laboratory of Immunodermatology, Department of Dermatology, Medical University of Lodz, Lodz, Poland
    Arch Dermatol Res 299:239-43. 2007
    b>Pemphigus is a severe autoimmune disease characterized by circulating and bound in vivo pemphigus autoantibodies...
  52. ncbi The efficacy of nicotinamide gel 4% as an adjuvant therapy in the treatment of cutaneous erosions of pemphigus vulgaris
    Fariba Iraji
    Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
    Dermatol Ther 23:308-11. 2010
    The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy...
  53. ncbi Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: a step toward antigen-specific therapy?
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 126:11-3. 2006
    ..Thus, blockade of this ligand-receptor interaction can prevent the development of antibody-mediated autoimmune diseases through different mechanisms...
  54. ncbi Anti-desmoglein IgG autoantibodies in patients with pemphigus in remission
    E J Kwon
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Eur Acad Dermatol Venereol 22:1070-5. 2008
    ..assay (ELISA) is a highly sensitive and specific method to detect anti-Dsg3 and anti-Dsg1 IgG autoantibodies in pemphigus vulgaris (PV) and pemphigus foliaceus (PF), respectively...
  55. ncbi Detection of pemphigus autoantibodies by IIF and ELISA tests in patients with pemphigus vulgaris and foliaceus and in healthy relatives
    Jolanta D Torzecka
    Laboratory of Immunochemical Research, Polish Mother s Memorial Hospital, Łódź, Poland
    Med Sci Monit 9:CR528-33. 2003
    b>Pemphigus is a life-threatening, autoimmune blistering disease, mediated by IgG autoantibodies...
  56. ncbi Prevalence of thyroid autoimmunity in patients with pemphigus vulgaris
    Fabian Pitoia
    Division Endocrinologia, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires
    Medicina (B Aires) 65:307-10. 2005
    Among bullous diseases, pemphigus vulgaris (PV) is a classical variety of this type of skin disorders. To establish the real prevalence of thyroid abnormalities in such a disease, a prospective study was developed...
  57. pmc Detection of autoantibodies against recombinant desmoglein 1 and 3 molecules in patients with pemphigus vulgaris: correlation with disease extent at the time of diagnosis and during follow-up
    Anna Belloni-Fortina
    Unit of Dermatology, University of Padua, Via Cesare Battisti 206, 35128 Padua, Italy
    Clin Dev Immunol 2009:187864. 2009
    The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them...
  58. doi New targets of pemphigus vulgaris antibodies identified by protein array technology
    Mina Kalantari-Dehaghi
    Exp Dermatol 20:154-6. 2011
    We performed partial evaluation of pemphigus vulgaris (PV) autoantibody profile using the protein array technology...
  59. pmc Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus
    Giuseppe Bifulco
    Department of Gynecology and Obstetrics, and Pathophysiology of Human Reproduction, University of Naples Federico II, Italy
    BMC Cancer 10:324. 2010
    b>Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission...
  60. pmc Protective endogenous cyclic adenosine 5'-monophosphate signaling triggered by pemphigus autoantibodies
    Volker Spindler
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    J Immunol 185:6831-8. 2010
    b>Pemphigus vulgaris (PV) is an autoimmune skin disease mediated by autoantibodies directed against the cadherin-type cell adhesion molecules desmoglein (Dsg) 3 and Dsg1 and is characterized by loss of keratinocyte cohesion and epidermal ..
  61. ncbi Immunopathologic features of pemphigus in the east Mediterranean region of Turkey: a prospective study
    Ayse Akman
    Department of Dermatology, Akdeniz University, School of Medicine, Antalya, Turkey
    Skinmed 8:12-6. 2010
    b>Pemphigus, a life-threatening autoimmune disorder, is the most common autoimmune bullous disease in the Mediterranean region of Turkey. No studies have investigated the immunopathologic features of this geographic setting...
  62. ncbi Increased antibody levels to desmogleins 1 and 3 after administration of carbamazepine
    T Yoshimura
    Pharmaceutical Division, Ogaki Municipal Hospital, Ogaki, Japan
    Clin Exp Dermatol 26:441-5. 2001
    Desmoglein (Dsg) 1 and Dsg3 are recognized as the autoantigens in pemphigus foliaceus and pemphigus vulgaris...
  63. ncbi Pemphigus: analysis of 1209 cases
    Cheyda Chams-Davatchi
    Tehran University for Medical Sciences, Department of Dermatology, Pemphigus Research Unit, Razi Hospital, Tehran, Iran
    Int J Dermatol 44:470-6. 2005
    b>Pemphigus is a rare and chronic life-threatening disease. The clinical picture varies in reports from different regions of the world.
  64. ncbi Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study
    G Marazza
    Service de Dermatologie, Hopitaux Universitaires de Geneve, 1211 Geneva 14, Switzerland
    Br J Dermatol 161:861-8. 2009
    Bullous pemphigoid (BP), pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune bullous diseases characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens ..
  65. ncbi Pemphigus antibody induced phosphorylation of keratinocyte proteins
    David S Rubenstein
    Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7287, USA
    Autoimmunity 39:577-86. 2006
    The pemphigus family of autoimmune blistering diseases is characterized by an autoantibody response to desmosomal cadherins in epithelia...
  66. ncbi Prevalence of non-organ-specific autoantibodies in patients with pemphigus vulgaris
    David A Blondin
    Faculty of Medicine, Department of Medicine, University of Calgary, Calgary, AB, Canada
    J Cutan Med Surg 13:82-7. 2009
    b>Pemphigus vulgaris (PV) is a potentially life-threatening, organ-specific, autoimmune, blistering disease of the skin and mucous membranes...
  67. ncbi An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris
    Maider Pretel
    Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Navarra, Spain
    Exp Dermatol 18:771-80. 2009
    b>Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by the presence of IgG autoantibodies against Dsg3...
  68. ncbi Paraneoplastic autoimmune multiorgan syndrome: 20 years after
    Annette Czernik
    Department of Dermatology Zot 2400 C340 Medical Sciences 1 Irvine, CA 92697 2400, USA
    Int J Dermatol 50:905-14. 2011
    ..of classification and delineate clinical and histological features and pathophysiology of paraneoplastic pemphigus. This is a paraneoplastic disease of epithelial autoimmunity and adhesion originally described by Dr...
  69. ncbi Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes
    Y Aoyama
    Department of Dermatology, Okayama Rosai Hospital and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Br J Dermatol 162:1049-55. 2010
    b>Pemphigus vulgaris (PV) is characterized by autoantibodies against desmoglein (Dsg) 3 or both Dsg1 and Dsg3, i.e. desmosomal adhesion molecules.
  70. ncbi A subset of pemphigus foliaceus patients exhibits pathogenic autoantibodies against both desmoglein-1 and desmoglein-3
    Luis A Arteaga
    Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
    J Invest Dermatol 118:806-11. 2002
    In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1...
  71. ncbi Comparison of enzyme-linked immunosorbent assay test with immunoblot assay in the diagnosis of pemphigus in Indian patients
    Sujay Khandpur
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Dermatol Venereol Leprol 76:27-32. 2010
    The diagnosis of pemphigus vulgaris (PV) and pemphigus foliaceous (PF) rests upon clinical, histological and immunofluorescence features...
  72. ncbi Pemphigus vulgaris: environmental factors. Occupational, behavioral, medical, and qualitative food frequency questionnaire
    S Brenner
    Department of Dermatology, Tel Aviv Elias Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Dermatol 40:562-9. 2001
    There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. Factors suggested include exposure to pesticides or certain drugs.
  73. ncbi Antiphospholipid antibodies in patients with autoimmune blistering disease
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa 920 8641, Japan
    J Am Acad Dermatol 57:397-400. 2007
    ..Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD)...
  74. pmc Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
    Dedee F Murrell
    Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
    J Am Acad Dermatol 58:1043-6. 2008
    Our scientific knowledge of pemphigus has dramatically progressed in recent years...
  75. ncbi Mechanisms of blister induction by autoantibodies
    Cassian Sitaru
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 14:861-75. 2005
    ..Autoantibodies from patients with pemphigus diseases can exert a direct effect just by binding to their target mediated by steric hindrance and/or by ..
  76. pmc Reliability and convergent validity of two outcome instruments for pemphigus
    Misha Rosenbach
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19119, USA
    J Invest Dermatol 129:2404-10. 2009
    A major obstacle in performing multicenter controlled trials for pemphigus is the lack of a validated disease activity scoring system. Here, we assess the reliability and convergent validity of the PDAI (pemphigus disease area index)...
  77. ncbi Induction of hyper-adhesion attenuates autoimmune-induced keratinocyte cell-cell detachment and processing of adhesion molecules via mechanisms that involve PKC
    Nicola Cirillo
    Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
    Exp Cell Res 316:580-92. 2010
    ..and molecular significance of hyper-adhesion in a system challenged by autoimmune sera from patients with Pemphigus Vulgaris (PV), a disease primarily targeting desmosomal adhesion...
  78. ncbi Rituximab mediates a strong elevation of B-cell-activating factor associated with increased pathogen-specific IgG but not autoantibodies in pemphigus vulgaris
    Angela Nagel
    Department of Dermatology and Allergology, Philipps University, Marburg, Germany
    J Invest Dermatol 129:2202-10. 2009
    b>Pemphigus vulgaris (PV) is a severe autoimmune disease affecting the skin and mucous membranes, characterized by autoantibodies mainly against desmoglein 3 (dsg3)...
  79. ncbi Paraneoplastic pemphigus
    Xuejun Zhu
    Department of Dermatology, Peking University First Hospital, Beijing, China
    J Dermatol 34:503-11. 2007
    Paraneoplastic pemphigus (PNP) is a life-threatening autoimmune blistering skin disease. Clinically, it is characterized by severe mucosal erosions and various cutaneous lesions associated with lymphoproliferative neoplasmas...
  80. ncbi E-cadherin is an additional immunological target for pemphigus autoantibodies
    Flor Evangelista
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 128:1710-8. 2008
    b>Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune blistering diseases characterized by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively...
  81. ncbi Blistering disorders: diagnosis and treatment
    S W Yeh
    Department of Oral Medicine, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    Dermatol Ther 16:214-23. 2003
    ..A brief review is presented of the following bullous diseases: pemphigus, paraneoplastic pemphigus, bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, ..
  82. pmc Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies
    Bichchau Nguyen
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5152, USA
    J Invest Dermatol 129:1710-8. 2009
    b>Pemphigus vulgaris (PV) is an autoimmune bullous disease in which autoantibodies against proteins of the desmosomal adhesion complex perturb desmosomal function, leading to intercellular adhesion defects in the oral mucosa and skin...
  83. ncbi Development of pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatment
    Carla Sanchez-Palacios
    Department of Dermatology, Northwestern University Medical School, Chicago, IL 60612, USA
    J Cutan Pathol 31:346-9. 2004
    b>Pemphigus is an autoimmune blistering disease of the skin and mucous membranes...
  84. ncbi Rituximab in severe pemphigus
    Enno Schmidt
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Ann N Y Acad Sci 1173:683-91. 2009
    b>Pemphigus is a life-threatening autoimmune bullous disorder that requires long-term treatment with systemic corticosteroids mostly in conjunction with further immunosuppressants...
  85. pmc Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology
    Steve Marchenko
    Department of Dermatology and Biological Chemistry, Institute for Immunology, University of California, Irvine, California 92697, USA
    J Biol Chem 285:3695-704. 2010
    A loss of epidermal cohesion in pemphigus vulgaris (PV) results from autoantibody action on keratinocytes (KCs) activating the signaling kinases and executioner caspases that damage KCs, causing their shrinkage, detachment from ..
  86. ncbi Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of current data
    Hakan M Gürcan
    Center for Blistering Diseases, New England Baptist Hospital, Boston, Massachusetts 02120, USA
    Am J Clin Dermatol 10:383-96. 2009
    ..It is also used as an adjuvant in the treatment of pemphigus and pemphigoid...
  87. ncbi Role of Rho GTPases in desmosomal adhesion and pemphigus pathogenesis
    Volker Spindler
    Institute of Anatomy and Cell Biology, University of Wurzburg, Germany
    Ann Anat 193:177-80. 2011
    ..This function is impaired in the disease pemphigus, in which patients develop autoantibodies against the cadherin-type desmosomal core proteins desmogleins...
  88. ncbi Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris
    Abhigyan Satyam
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Immunol Invest 38:498-509. 2009
    b>Pemphigus vulgaris (PV) is classical example of antigen-driven severe autoimmune bullous skin disorder. Auto reactive T cells are critical for the induction and regulation of antibody production...
  89. pmc Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3
    Jean M Jennings
    Departments of Cell Biology and Dermatology, Emory University, Atlanta, Georgia, USA
    J Invest Dermatol 131:706-18. 2011
    b>Pemphigus vulgaris (PV) is an epidermal blistering disorder caused by antibodies directed against the desmosomal cadherin desmoglein-3 (Dsg3). The mechanism by which PV IgG disrupts adhesion is not fully understood...
  90. ncbi Oral lesions in patients with pemphigus vulgaris and bullous pemphigoid
    Jozo Budimir
    School of Dental Medicine, University of Zagreb, Croatia
    Acta Clin Croat 47:13-8. 2008
    ..compare data on age and gender, habits, lesion localization, onset of symptoms and therapy between patients with pemphigus vulgaris and those suffering from bullous pemphigoid...
  91. ncbi Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris
    Kazuyuki Tsunoda
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Eur J Immunol 32:627-33. 2002
    Mechanisms of tolerance break against desmoglein 3 (Dsg3) in patients with pemphigus vulgaris (PV) producing pathogenic anti-Dsg3 IgG autoantibodies are unclear...
  92. ncbi Rituximab immunotherapy in pemphigus: therapeutic effects beyond B-cell depletion
    Giovanna Zambruno
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 128:2745-7. 2008
    ..Two studies in this issue investigate the effects of rituximab in pemphigus. Rituximab induces not only a depletion of all B cells and a decline of antidesmoglein autoantibodies but also a ..
  93. pmc Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus
    Wolfgang Moritz Heupel
    Department of Anatomy and Cell Biology, University of Wurzburg, Koellikerstr 6, D 97070 Wurzburg
    J Biol Chem 284:8589-95. 2009
    b>Pemphigus vulgaris (PV) autoantibodies directly inhibit desmoglein (Dsg) 3-mediated transinteraction...
  94. ncbi Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 181:1526-35. 2008
    ..the in vivo pathogenicity of desmoglein 3 (Dsg3)-reactive T cells at a clonal level in a mouse model for pemphigus vulgaris (PV), an autoimmune blistering disease induced by anti-Dsg3 autoantibodies...
  95. ncbi Pemphigus vegetans presenting as acrodermatitis continua suppurativa
    Laszlo Török
    Department of Dermatology, County Hospital, Nagykörösi u 15, 6000 Kecskemét, Hungary
    Eur J Dermatol 13:579-81. 2003
    ..cleft and eosinophilia), as well as the data of immunohistological findings supported the diagnosis of pemphigus vegetans Hallopeau...
  96. ncbi Antibodies against desmoglein 1 in healthy subjects in endemic and nonendemic areas of pemphigus foliaceus (fogo selvagem) in Peru
    Alex G Ortega Loayza
    Clinical Research Institute, Universidad Nacional Mayor de San Marcos, Lima, Peru
    Int J Dermatol 45:538-42. 2006
    Endemic pemphigus foliaceus or fogo selvagem is an autoimmune skin disease characterized by the presence of subcorneal superficial blisters and antibodies of the immunoglobulin G4 (IgG4) class specific for the desmosomal glycoprotein, ..
  97. ncbi Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance
    Naoko Wada
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 131:410-7. 2011
    ..We examined the expression of desmoglein 3 (Dsg3), the autoantigen in pemphigus vulgaris (PV), in mouse thymus and the involvement of Aire in tolerance to Dsg3...
  98. ncbi Prevalence of anti-desmoglein-3 antibodies in endemic regions of Fogo selvagem in Brazil
    Julio Hilario-Vargas
    Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
    J Invest Dermatol 126:2044-8. 2006
    Fogo selvagem (FS), the endemic form of pemphigus foliaceus (PF), is an autoimmune blistering disease characterized by autoantibodies against desmoglein 1...
  99. ncbi Paraneoplastic pemphigus in association with Castleman's disease
    O V Nikolskaia
    Department of Dermatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building, Suite 771, Baltimore, MD 21205, U S A
    Br J Dermatol 149:1143-51. 2003
    Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease associated with lymphoproliferative neoplasms, and frequently with a very rare tumour, Castleman's disease.
  100. ncbi Randomized controlled trial of adjuvant oral dexamethasone pulse therapy in pemphigus vulgaris: PEMPULS trial
    Leon F Mentink
    Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Arch Dermatol 142:570-6. 2006
    To determine the therapeutic effect of adjuvant dexamethasone pulse therapy when given in addition to conventional treatment of pemphigus vulgaris.
  101. ncbi The efficacy and safety of rituximab in refractory pemphigus: a review of case reports
    Kattie J Allen
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Drugs Dermatol 6:883-9. 2007
    ..In addition, rituximab has been used for many other diseases, including refractory pemphigus. In this study, 42 case reports of patients with refractory pemphigus vulgaris, pemphigus foliaceus, and ..

Research Grants63

  1. Desmoglein 2 Function in Cell Adhesion and Pemphigus
    MY MAHONEY; Fiscal Year: 2003
    ..In the human autoimmune blistering disease pemphigus, antibodies directed against Dsg1 and Dsg3 induce blister formation in the epidermis and oral mucosa...
  2. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..e., atopic dermatitis, psoriais, contact dermatitis, and pemphigus vulgaris. Foxp3+ regulatory T cells (T regs) play a critical role in skin immunoregulation...
  3. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This grant is aimed at discovering the etiology of endemic pemphigus foliaceus (PF), also known as Fogo Selvagem (FS) in rural Brazil...
  4. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2013
    Project summary (30 lines maximum): Pemphigus is a group of potentially fatal blistering diseases characterized by autoantibodies against desmoglein (Dsg) cell adhesion proteins...
  5. ADHESION JUNCTION REGULATION IN NORMAL AND DISEASED SKIN
    David S Rubenstein; Fiscal Year: 2012
    ..Funding of this grant over the past 4 years has enabled us to further elucidate the mechanism by which pemphigus IgG induce loss of adhesion in target keratinocytes...
  6. Function of Desmoglein 1/Pemphigus Foliaceus Antigen
    KATHLEEN JANEE GREEN; Fiscal Year: 2013
    ....
  7. High throughput screening to find inhibitors of pathogenic pemphigus antibodies
    John R Stanley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease affecting skin and mucous membranes that is mediated by circulating antibodies against a keratinocyte ..
  8. Regulation of TSLP-Mediated Skin Inflammation
    Steven F Ziegler; Fiscal Year: 2013
    ..immune responses in the skin can be dire and include inflammatory diseases such as psoriasis, scleroderma and pemphigus vulgaris, as well as allergic responses that lead to acute and chronic atopic dermatitis (AD) and allergic ..
  9. Zona Pellucida: Immunopathologic Study
    Kenneth S K Tung; Fiscal Year: 2013
    ..Our study will define many Treg functions relevant to many common human diseases such as: pemphigus vulgaris, IC disease (SLE), Sjogren's syndrome, APS1, gastritis, and male and female idiopathic infertility ..
  10. Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease Pemphigus
    Andrew P Kowalczyk; Fiscal Year: 2012
    b>Pemphigus is a class of devastating epidermal blistering diseases in which autoantibodies are generated against cell-cell adhesion molecules present in the skin and mucous membranes...
  11. Cloning and genetics of human pemphigus autoantibodies
    John R Stanley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pemphigus vulgaris and foliaceus are disfiguring and potentially life-threatening autoimmune blistering diseases affecting skin and mucous membranes that are mediated by autoantibodies against ..
  12. PEMPHIGUS AND PEMPHIGOID
    Luis A Diaz; Fiscal Year: 2011
    ..non-pathogenic and persistent response detected in normal individuals to a frankly pathogenic reaction found in pemphigus vulgaris (PV) and pemphigus foliaceus/fogo selvagem (PF/FS) patients...
  13. MHC proteins, copolymers and peptide 15mers in EAE
    Jack L Strominger; Fiscal Year: 2010
    ..such as rheumatoid arthritis, multiple sclerosis and diabetes occur at high frequency while others, such as pemphigus vulgaris have a low frequency. All of these diseases are linked to specific histocompatibilty proteins...
  14. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is strongly associated with MHC class II alleles that are rare ..
  15. Interactions of lgC4 &lgE anti-Dsg1 Autoantibodies in Endemic Pemphigus Foliaceu
    Ye Qian; Fiscal Year: 2013
    ..studying the mechanism of the development of auto antibodies in endemic [Fogo Selvagem (FS)] and non-endemic pemphigus foliaceus (PF) and pemphigus vulgaris (PV)...
  16. INVESTIGATION Of HUMAN COMPLEMENT
    CHESTER ALPER; Fiscal Year: 1999
    ..MHC markers for a wide variety of diseases, including type I diabetes mellitus, gluten-sensitive enteropathy, pemphigus vulgaris, and 21-hydroxylase deficiency congenital adrenal hyperplasia...
  17. CHARACTERIZATION OF THE PEMPHIGUS FOLIACEUS ANTIGEN
    Grant Anhalt; Fiscal Year: 1993
    DESCRIPTION (Adapted from the applicant's abstract): Pemphigus foliaceus (PF) is an autoimmune skin disease that has been recently characterized as a simple model for other organ-specific, antibody-mediated autoimmune diseases...
  18. SKIN-REACTIVE MICROCOCCAL EXOPROTEINS--MOLECULAR BIOLOGY
    KIRK WUEPPER; Fiscal Year: 1990
    ..Although many epidemics of pemphigus neonatorum and SETS were attribiuted to beta lactamase-producing, phage group II staphylococci, other ..
  19. PATHOPHYSIOLOGY OF EXPERIMENTALLY INDUCED PEMPHIGUS
    Grant Anhalt; Fiscal Year: 1993
    ..abstract): The long-term goals of the principal investigator are definition of the pathogenic role of pemphigus and pemphigoid autoantibodies in the production of cutaneous lesions, primarily through the use of an in vivo ..
  20. Role of the matrix metalloproteinase in pemphigus autoantibody-mediated epidermal
    Ning Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal autoimmune skin blistering diseases...
  21. Pemphigus & Pemphigoid: from the bench to the bedside
    Sergei A Grando; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pemphigus and pemphigoid are serious blistering diseases of the skin...
  22. Role of Glycosylation of Dsg1 in Pemphigus acantholysis
    Ning Li; Fiscal Year: 2009
    ..Her research plan explores the role of glycans on pemphigus antigen/auto antibody interactions...
  23. PEMPHIGUS AND PEMPHIGOID
    Luis Diaz; Fiscal Year: 1999
    This application is a competitive continuation of the grant "Pemphigus and Pemphigoid" seeking support for studies on the immunopathology of these diseases...
  24. Mechanisms of Blister Formation by Staphylococcal Toxins
    John Stanley; Fiscal Year: 2006
    ..In pemphigus foliaceus autoantibodies that cause dysfunction of Dsg 1 cause blisters identical to those caused by ETA in the ..
  25. ANTIGENS RECOGNIZED BY PEMPHIGUS AUTOANTIBODIES
    Robert Goldman; Fiscal Year: 1990
    ..in this application is aimed at determining the causative factors involved in the blistering skin disease pemphigus. These studies are based on our initial findings that pemphigus patients contain circulating autoantibodies ..
  26. PATHOPHYSIOLOGY OF PEMPHIGUS IN VIVO
    Grant Anhalt; Fiscal Year: 2002
    b>Pemphigus is an organ specific autoimmune disease. Over the last two decades, the molecular basis and pathophysiology of the disease has been defined as follows. IgG class autoantibodies target molecules of the cadherin supergene family...
  27. Novel Therapy for Pemphigus Vulgaris by Treatment with a Cholinergic Agonist
    Susan Wright; Fiscal Year: 2009
    b>Pemphigus vulgaris (PV) is a chronic autoimmune disease targeting skin and mucous membranes, characterized by intraepithelial aphlegmasic flaccid blisters and erosions...
  28. PSORIASIS AND ICHTHYOSIS IN VIVO AND IN CELL CULTURE
    JOSEPH MC GUIRE; Fiscal Year: 1990
    ..plasminogen activator, cross-linked envelope formation, the pattern of keratin synthesis and the presence of pemphigus vulgaris antigen...
  29. STEROID SULFATASE AND STRATUM CORNEUM CELL COHESION
    Ervin Epstein; Fiscal Year: 1991
    ..an examination of the antigens to which autoimmune antibodies develop in the acquired bullous diseases such as pemphigus. These autoantibodies clearly are the proximate cause of the blistering in at least some of these diseases, but ..
  30. Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease Pemphigus
    Andrew Kowalczyk; Fiscal Year: 2007
    b>Pemphigus is a class of devastating epidermal blistering diseases in which autoantibodies are generated against cell-cell adhesion molecules present in the skin and mucous membranes...
  31. PATHOGENICITY OF PEMPHIGUS AND PEMPHIGOID ANTIBODIES
    Grant Anhalt; Fiscal Year: 1991
    ..has been systematically defining pathogenetic mechanisms that are operative in the autoimmune cutaneous disease pemphigus. The animal model we have developed, employing passive transfer of human autoantibodies in neonatal mice, has ..
  32. DESMOGLEIN I IN THE PATHOGENESIS OF PEMPHIGUS FOLIACEUS
    MALCOLM STEINBERG; Fiscal Year: 1990
    ..determine whether the appearance of epidermal blisters (acantholysis) characteristic of the autoimmune disease pemphigus foliaceus (PG) is caused by autoantibodies against the desmosomal glycoprotein desmoglein I (DG I)...
  33. THE IMMUNOPATHOLOGY OF PEMPHIGUS AND BULLOUS PEMPHIGOID
    Robert Jordon; Fiscal Year: 1990
    The objectives are to continue to investigate immunopathogenic mechanisms in pemphigus and bullous pemphigoid...
  34. Pemphigus IgG Internalization and Desmosome Disassembly
    Andrew Kowalczyk; Fiscal Year: 2004
    b>Pemphigus vulgaris (PV) is a severe autoimmune blistering disease characterized by the disruption of adhesion between epithelial cells in the oral mucosa and in the lower layers of the epidermis...
  35. ISOLATION OF PEMPHIGUS ANTIGEN CDNA
    Madeleine Duvic; Fiscal Year: 1990
    b>Pemphigus vulgaris is a severe blistering disease characterized by a circulating IgG which binds to an unknown epidermal cell antigen and causes epidermal disadherance...
  36. MECHANISMS OF PHOTO-IMMUNOREGULATION
    Carole Berger; Fiscal Year: 1990
    ..modality may be valuable in the management of cutaneous T cell lymphoma (CTCL) and the autoimmune disease pemphigus vulgaris (PV)...
  37. FUNCTION OF PEMPHIGUS VULGARIS ANTIGEN
    John Stanley; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the applicant's abstract) Pemphigus vulgaris (PV) is a life-threatening blistering skin disease in which autoantibodies against the cell surface of keratinocytes cause them to separate...
  38. PEMPHIGUS AS A MODEL ORGAN-SPECIFIC AUTOIMMUNE DISEASE
    Jean Claude Bystryn; Fiscal Year: 2001
    DESCRIPTION (Taken from the applicant's abstract): The purpose of the Pemphigus Conference will be to bring together scientists working in basic immunological aspects of human autoimmunity and those working in pemphigus research...
  39. CELLULAR IMMUNE RESPONSES IN PEMPHIGUS VULGARIS
    Mong Shang Lin; Fiscal Year: 2003
    ....
  40. PROTEINASES AND MEDIATORS IN CUTANEOUS BIOLOGY
    ROBERT LAVKER; Fiscal Year: 1993
    ..Special consideration will be given to: psoriasis, pemphigus, urticaria pigmentosum and diseases with evidence of mast cell activation...
  41. Nicotinic receptor-mediated action of tobacco nitrosamines on respiratory cells
    SERGEI GRANDO; Fiscal Year: 2007
    ..These findings will open a door for future mechanistic studies of the intracellular signaling pathways mediating the carcinogenic and tumor-promoting actions of tobacco nitrosamines. [unreadable] [unreadable] [unreadable]..
  42. SERUM CYT-MAA AS AN EARLY MARKER OF RESPONSE TO THERAPY IN RESECTED MELANOMA
    Jean Claude Bystryn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Role of Apoptosis in Pemphigus
    Ning Li; Fiscal Year: 2008
    b>Pemphigus is a group of life-threatening autoimmune blistering diseases characterized by pathogenic IgG autoantibodies against desmogleins (Dsg) and intraepidermal cell-cell detachment (acantholysis). ...
  44. Can nicotinic antagonists prevent tobacco smoke-induced*
    SERGEI GRANDO; Fiscal Year: 2006
    ....
  45. PEMPHIGUS 2005-PROGRESS AND FUTURE DIRECTIONS
    Jean Claude Bystryn; Fiscal Year: 2005
    b>Pemphigus is a serious blistering disease of the skin. It is a model auto-antibody mediated disease, caused by auto-antibodies against the keratinocyte adhesion molecules desmoglein 1 and 3...
  46. POLYVALENT VACCINE IN IL-2+GM-CSF LIPOSOMES FOR MELANOMA
    Jean Claude Bystryn; Fiscal Year: 2004
    ..More broadly, it may provide a general method of potentiating the immunogenicity of vaccines against other cancers and to infectious diseases. ..
  47. Regulation of Keratinocyte Migration by Acetylcholine
    Sergei A Grando; Fiscal Year: 2010
    ..This study will identify potential therapeutic agents among cholinergic drugs acting upon specific types of ACh receptors to activate signaling pathways mediating keratinocyte functions during wound epithelialization. ..
  48. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..to investigate the molecular basis for the protective property of IVIG in the autoimmune blistering diseases pemphigus and pemphigoid. Pemphigus and pemphigoid are a group of potentially fatal organ specific autoimmune diseases...
  49. TRAINING GRANT IN DERMATOLOGICAL RESEARCH
    Luis Diaz; Fiscal Year: 2006
    ..This competitive grant application requests funding to support the training at the UNC Dermatology Department of the next generation of dermatological investigators. ..
  50. Indiana and the Legacy of State and Local Eugenics 1907-2007
    William Schneider; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. 2005 Epithelial Differentiation Keratinization-GRC
    Angela Christiano; Fiscal Year: 2005
    ..The specific goal of this proposal is to generate funds to support the travel, registration and subsistence for the speakers, chairs and major participants in the conference. ..
  52. Epithelial Reprogramming
    Angela Christiano; Fiscal Year: 2003
    ....