Genomes and Genes
Summary: A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis.
Publications284 found, 100 shown here
- Bullous pemphigoid: a prototypical antibody-mediated organ-specific autoimmune diseaseCassian Sitaru
Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
J Invest Dermatol 129:822-4. 2009b>Bullous pemphigoid (BP) is a prototypical organ-specific autoimmune disease. Autoantibodies unfold their blister-inducing potential by triggering an Fcgamma-dependent inflammatory reaction. The study by Iwata et al...
- Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230Maria Kiss
Department of Dermatology and Allergology, University of Szeged, H 6720 Szeged, Koranyi fasor 6, Hungary
J Autoimmun 24:1-10. 2005b>Bullous pemphigoid (BP) is an IgG-mediated autoimmune blistering disease that targets the hemidesmosomal proteins BP230 and BP180...
- Multicenter prospective study of the humoral autoimmune response in bullous pemphigoidGiovanni Di Zenzo
Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
Clin Immunol 128:415-26. 2008b>Bullous pemphigoid (BP) is an autoimmune bullous disease, associated with autoantibodies directed against the hemidesmosomal components BP180 and BP230...
- A comparison of oral and topical corticosteroids in patients with bullous pemphigoidPascal Joly
Department of Dermatology and Biostatistics, INSERM Unite 519, University of Rouen, Rouen, France
N Engl J Med 346:321-7. 2002b>Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly...
- Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort studyS M Langan
Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
BMJ 337:a180. 2008To determine the incidence of and mortality from bullous pemphigoid and pemphigus vulgaris in the United Kingdom.
- Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degenerationL Guo
Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Cell 81:233-43. 1995BPAG1 is the major antigenic determinant of autoimmune sera of bullous pemphigoid (BP) patients...
- A case of chronic herpes gestationis: persistent disease or conversion to bullous pemphigoid?Lauretta Amato
Department of Dermatology, University of Florence, Florence, Italy
J Am Acad Dermatol 49:302-7. 2003..We present this case as chronic persistent HG and discuss the differential diagnosis between chronic persistent HG and HG evolving to bullous pemphigoid, together with a careful examination of similar cases reported in literature.
- Macrophage migration inhibitory factor (MIF) in bullous pemphigoidYukie Asano
J Dermatol Sci 49:95-7. 2008
- Neurological disorders in patients with bullous pemphigoidNadege Cordel
Department of Dermatology, Pointe à Pitre University Hospital, Pointe a Pitre, Guadeloupe, Pointe A Pitre cedex, France
Dermatology 215:187-91. 2007Unexpected cases of bullous pemphigoid (BP) have been reported in adult patients with various neurological disorders suggesting a possible relationship between these diseases.
- Activation of blood coagulation in bullous pemphigoid: role of eosinophils, and local and systemic implicationsA V Marzano
Department of Internal Medicine, IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli, Regina Elena, Milan, Italy
Br J Dermatol 160:266-72. 2009b>Bullous pemphigoid (BP) is a blistering skin disease caused by autoantibodies to hemidesmosomal proteins, with eosinophils participating in blister formation...
- The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsoneE Schmidt
Department of Dermatology, , , Germany
Clin Exp Immunol 124:157-62. 2001b>Bullous pemphigoid (BP) is a subepidermal blistering disease associated with autoantibodies to the hemidesmosomal 180 kD BP autoantigen (BP180)...
- Bullous pemphigoid and internal diseases - A case-control studyHana Jedlickova
Ist Department of Dermatovenereology, Masaryk University, St Anna Faculty Hospital, 656 91, Brno, Czech Republic
Eur J Dermatol 20:96-101. 2010To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control study assessing the frequency of selected diseases - diabetes mellitus, neurological diseases, malignant tumors, benign ..
- Evaluation of a new ELISA assay for detection of BP230 autoantibodies in bullous pemphigoidMarilina Tampoia
Clinical Pathology Laboratory, Polyclinic of Bari, Bari, Italy
Ann N Y Acad Sci 1173:15-20. 2009The diagnosis of bullous pemphigoid is based on clinical observations and on the presence of autoantibodies directed against proteins of the dermoepidermal junction...
- Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoidLisa Leighty
Department of Dermatology, University of North Carolina School of Medicine, 3100 Thurston Bowles, Chapel Hill, NC 27599, USA
Arch Dermatol Res 299:417-22. 2007b>Bullous pemphigoid (BP) is a subepidermal skin blistering disease characterized immunohistologically by dermal-epidermal junction (DEJ) separation, an inflammatory cell infiltrate in the upper dermis, and autoantibodies targeted toward ..
- Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse modelZhi Liu
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Autoimmun 31:331-8. 2008b>Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome...
- A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized studyPascal Joly
Department of Dermatology, INSERM U901, University of Rouen, Rouen, France
J Invest Dermatol 129:1681-7. 2009Superpotent topical corticosteroids (CS) have been demonstrated to improve bullous pemphigoid (BP) patients' survival...
- Multiple sclerosis and bullous pemphigoid: a casual association or a pathogenetic correlation?Giuseppe Stinco
Institute of Dermatology, Department of Clinical and Experimental Pathology and Medicine, University of Udine, Gemona Hospital, Via Battiferro, 1, 33123 Gemona del Friuli Ud, Italy
Eur J Dermatol 12:186-8. 2002The literature reports about thirty cases of bullous pemphigoid (BP) which developed in patients affected by multiple sclerosis (MS), although a relationship between these two diseases has not yet been identified...
- A retrospective epidemiological study on the association of bullous pemphigoid and neurological diseasesGiuseppe Stinco
Department of Clinical and Experimental Pathology and Medicine, DPMSC Institute of Dermatology, University of Udine, 33013 Gemona del Friuli, Italy
Acta Derm Venereol 85:136-9. 2005b>Bullous pemphigoid is a rare chronic recurrent dermatosis that is often reported in association with various neurological diseases...
- A major role for neutrophils in experimental bullous pemphigoidZ Liu
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Clin Invest 100:1256-63. 1997b>Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein, BP180...
- The pathophysiology of bullous pemphigoidMichael Kasperkiewicz
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
Clin Rev Allergy Immunol 33:67-77. 2007b>Bullous pemphigoid (BP) is a blistering skin disease characterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal-epidermal junction, designated BP180 and BP230...
- Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodiesJ R Stanley
Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892
J Clin Invest 82:1864-70. 1988Autoantibodies from bullous pemphigoid (BP) patients define a 230-kD protein found in the basement membrane of stratified squamous epithelia...
- Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assemblyJan Koster
The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cell Sci 116:387-99. 2003..The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only to BP230, but also to plectin...
- Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoidSuying Feng
Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China
Int J Dermatol 47:225-8. 2008The 180-kDa transmembrane hemidesmosomal protein (BPAG2) has been identified as an important autoantigen in bullous pemphigoid (BP)...
- Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoidMariko Yoshida
Department of Dermatology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
J Dermatol Sci 41:21-30. 2006By immunoblot analyses of normal human epidermal extracts, the 230kDa bullous pemphigoid antigen (BP230) is recognized by most bullous pemphigoid (BP) sera...
- Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180G J Giudice
Department of Dermatology, Medical College of Wisconsin, Milwaukee
J Invest Dermatol 99:243-50. 1992b>Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the presence of subepidermal blisters resulting from a disruption of the adhesive interactions between basal keratinocytes and the cutaneous basement membrane...
- Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoidR Chen
Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
J Clin Invest 108:1151-8. 2001b>Bullous pemphigoid (BP) is an inflammatory subepidermal blistering disease associated with an IgG autoimmune response to the hemidesmosomal protein BP180...
- The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and musclesC L Leung
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Cell Biol 154:691-7. 2001b>Bullous pemphigoid antigen 1 (BPAG1) is a member of the plakin family with cytoskeletal linker properties. Mutations in BPAG1 cause sensory neuron degeneration and skin fragility in mice...
- Humanization of autoantigenWataru Nishie
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
Nat Med 13:378-83. 2007..Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect ..
- Bullous pemphigoid and related subepidermal autoimmune blistering diseasesEdit B Olasz
Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Curr Dir Autoimmun 10:141-66. 2008The pemphigoid group of autoimmune blistering diseases includes distinct entities (bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis and lichen planus pemphigoides) that are characterized by ..
- Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoidYukiko Tsuji-Abe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
J Dermatol Sci 37:145-9. 2005..by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP)...
- Oral lesions in patients with pemphigus vulgaris and bullous pemphigoidJozo Budimir
School of Dental Medicine, University of Zagreb, Croatia
Acta Clin Croat 47:13-8. 2008..onset of symptoms and therapy between patients with pemphigus vulgaris and those suffering from bullous pemphigoid. Based on clinical presentation, histopathologic analysis, direct and indirect immunofluorescence, Tzanck ..
- Bullous pemphigoid antigen 1 isoforms: potential new target autoantigens in multiple sclerosis?E Laffitte
Department of Dermatology, University Hospital, Geneva, Switzerland
Br J Dermatol 152:537-40. 2005The simultaneous occurrence of bullous pemphigoid (BP) and multiple sclerosis (MS), two autoimmune diseases involving the skin and the central nervous system (CNS), respectively, has been described.
- Bullous pemphigoid associated with dermatomyositis and colon carcinomaT Yanagi
Department of Dermatology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
Clin Exp Dermatol 32:291-4. 2007It has been suggested that both bullous pemphigoid (BP) and dermatomyositis are associated with internal malignancies. However, there are no reports of the coexistence of these three conditions in one patient...
- Two cases of subepidermal blistering disease with anti-p200 or 180-kD bullous pemphigoid antigen associated with psoriasisH Yasuda
Fukuzumi Skin Clinic, Fukuzumi, Toyohira, Sapporo, Japan
Dermatology 209:149-55. 2004..IgG antibodies bound to the epidermal side of salt-split skin. Immunoblot analysis identified a 180-kD bullous pemphigoid (BP) antigen in epidermal extracts...
- Management of bullous pemphigoid: recommendations for immunomodulatory treatmentsGudula Kirtschig
Department of Dermatology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
Am J Clin Dermatol 5:319-26. 2004In 1953, Lever differentiated bullous pemphigoid from autoimmune pemphigus. The natural course of bullous pemphigoid is relatively benign, with a disease-related mortality rate of 24% compared with around 70% in pemphigus...
- Cloning of hamster type XVII collagen cDNA, and pathogenesis of anti-type XVII collagen antibody and complement in hamster bullous pemphigoidKatsushi Yamamoto
Division of Oncology and Biology, Genome Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
J Invest Dermatol 118:485-92. 2002b>Bullous pemphigoid is an inflammatory subepidermal blistering skin disease associated with an IgG autoimmune response to the type XVII collagen...
- Methotrexate for bullous pemphigoid: preliminary studyCorina Bara
Arch Dermatol 139:1506-7. 2003
- Clinical significance of enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoidY Amo
Department of Dermatology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, 228 8555, Kanagawa, Japan
J Dermatol Sci 26:14-8. 2001The NC16A domain of the 180-kDa bullous pemphigoid antigen (BP180) is the most immunogenic and, probably, pathogenic region in bullous pemphigoid (BP)...
- Childhood bullous pemphigoid: a case report and 10-year follow upAna María Sáenz
Department of Dermatology, Hospital Universitario de Caracas, Luis Razetti School of Medicine, Central University of Venezuela, Caracas, Venezuela
Int J Dermatol 46:508-10. 2007b>Bullous pemphigoid (BP) is a very rare acquired immunbullous disease in children and infants...
- A population-based study of acute medical conditions associated with bullous pemphigoidS M Langan
Centre of Evidence Based Dermatology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
Br J Dermatol 161:1149-52. 2009b>Bullous pemphigoid is associated with poorly understood dramatically increased early mortality rates.
- [Bullous pemphigoid in an infant]Beatriz Sousa
Servico de Pediatria, Hospital de S Joao, Faculdade de Medicina, Porto
Acta Med Port 18:159-62. 2005b>Bullous pemphigoid is an acquired auto-immune blistering disease, which affects predominantly the elderly. It is rare in children and exceptional in infant. To our knowledge only ten cases were previously reported...
- BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoidMasakazu Kobayashi
Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Dermatol Sci 30:224-32. 2002b>Bullous pemphigoid (BP) is an acquired autoimmune subepidermal blistering disease against hemidesmosomal cytoplasmic BP230 and transmembrane BP180 proteins...
- Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old ageBerthold Rzany
Department of Dermatology, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
Arch Dermatol 138:903-8. 2002Although bullous pemphigoid (BP) is the most frequent autoimmune bullous disease and is associated with a considerable case-fatality rate, little is known about factors that influence its prognosis.
- Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skinCassian Sitaru
Department of Dermatology, University of Wurzburg, Wurzburg, Germany
J Invest Dermatol 118:664-71. 2002b>Bullous pemphigoid is a subepidermal autoimmune blistering disease associated with autoantibodies to the hemidesmosomal bullous pemphigoid antigens 180 and 230...
- Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoidS Verraes
FRE 2260 CNRS, IFR 53 Biomolecules, University of Reims-Champagne Ardennes, Reims, France
J Invest Dermatol 117:1091-6. 2001b>Bullous pemphigoid is a blistering disorder associated with autoantibodies directed against two components of hemidesmosomes, BP180 and BP230...
- Bullous pemphigoid: end of the century overviewZ Liu
Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
J Dermatol 28:647-50. 2001b>Bullous pemphigoid (BP) was first described by Lever in 1953 as a subepidermal blistering disease...
- Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoidIakov Shimanovich
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
J Pathol 204:519-27. 2004Epidermolysis bullosa acquisita (EBA) and bullous pemphigoid (BP) are two clinically and immunologically distinct autoimmune subepidermal blistering skin diseases associated with IgG autoantibodies against the dermal-epidermal junction...
- Childhood bullous pemphigoid: clinical and immunological findings in a series of 4 casesMaria Isabel Martinez-De Pablo
Department of Dermatology, Hospital Clinic, Barcelona, Spain
Arch Dermatol 143:215-20. 2007b>Bullous pemphigoid (BP) is an autoimmune blistering disease that is rare in childhood...
- Localized bullous pemphigoid overlying a fistula for hemodialysisJOSE PARDO
Service of Dermatology, Valencia University General Hospital, Spain
J Am Acad Dermatol 51:S131-2. 2004Two cases of bullous pemphigoid exclusively limited to the skin overlying a hemodialysis fistula in patients with chronic renal failure are reported...
- Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoidYayoi Niimi
Department of Dermatology, Nippon Medical School, Tokyo, Japan
Int Arch Allergy Immunol 139:104-13. 2006Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ.
- Annual incidence and mortality of bullous pemphigoid in the Grampian Region of North-east ScotlandV S Gudi
Department of Dermatology, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
Br J Dermatol 153:424-7. 2005Data on the annual incidence of bullous pemphigoid (BP) in the U.K. are scarce.
- Frequency of IgA antibodies in pemphigus, bullous pemphigoid and mucous membrane pemphigoidEmanuele Cozzani
Section of Dermatology, University of Genoa, Genoa, Italy
Acta Derm Venereol 84:381-4. 2004..Thirty-two patients with pemphigus, 73 with bullous pemphigoid and 28 with mucous membrane pemphigoid were studied retrospectively...
- Bullous pemphigoid in a leg affected with hemiparesia: a possible relation of neurological diseases with bullous pemphigoid?N Foureur
Department of Dermatology, Bichat Claude Bernard Hospital, 46, rue Henri Huchard 75018 Paris, France
Eur J Dermatol 11:230-3. 2001We report a typical case of bullous pemphigoid (BP) associated with a neurological disorder and study a possible link between neurological disorders and BP...
- Bullous pemphigoid in infancy: case report and literature reviewB Amos
Department of Dermatology, University of Pittsburgh, Pennsylvania, USA
Pediatr Dermatol 15:108-11. 1998We report a 2-month-old girl who developed bullous pemphigoid on her hands and feet shortly after receiving her routine immunizations...
- A homozygous in-frame deletion in the collagenous domain of bullous pemphigoid antigen BP180 (type XVII collagen) causes generalized atrophic benign epidermolysis bullosaS Chavanas
U385 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine, Nice, France
J Invest Dermatol 109:74-8. 1997We report a missplicing event affecting the expression of bullous pemphigoid antigen BP180 (type XVII collagen) in a patient with generalized atrophic benign epidermolysis bullosa (GABEB)...
- Risk factors for relapse in patients with bullous pemphigoid in clinical remission: a multicenter, prospective, cohort studyPhilippe Bernard
Service de Dermatologie, Hopital Robert Debre, avenue du Général Koenig, 51092 Reims Cedex, France
Arch Dermatol 145:537-42. 2009To identify prognostic factors for relapse in the first year after cessation of therapy in bullous pemphigoid (BP).
- Juvenile bullous pemphigoid: the presentation and follow-up of six casesM Gajic-Veljic
Department of Dermatology, School of Medicine, Pasterova 2, Belgrade, Serbia
J Eur Acad Dermatol Venereol 24:69-72. 2010Juvenile bullous pemphigoid (JBP) is a very rare autoimmune blistering disease. Up to now, 81 cases have been published.
- Childhood bullous pemphigoid: report of a case with characterization of the targeted antigensR M Trueb
Department of Dermatology, University Hospital of Zurich, Switzerland
J Am Acad Dermatol 40:338-44. 1999..demonstrated circulating IgG autoantibodies that reacted against a eukaryotic recombinant form of human bullous pemphigoid antigen 180 (BP180)...
- Hemidesmosomes: roles in adhesion, signaling and human diseasesL Borradori
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL 1066 CX, Amsterdam, The Netherlands
Curr Opin Cell Biol 8:647-56. 1996..These multiprotein complexes appear not only to mediate cell adhesion, but also to transduce signals from the extracellular matrix to the cell interior that may profoundly modulate cell behavior...
- The human 230-kD bullous pemphigoid antigen gene (BPAG1). Exon-intron organization and identification of regulatory tissue specific elements in the promoter regionK Tamai
Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
J Clin Invest 92:814-22. 1993The 230-kD bullous pemphigoid antigen (BPAG1), a hemidesmosomal protein, is encoded by a gene at the human chromosomal locus 6p11-12...
- Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective studyG Marazza
Service de Dermatologie, Hopitaux Universitaires de Geneve, 1211 Geneva 14, Switzerland
Br J Dermatol 161:861-8. 2009b>Bullous pemphigoid (BP), pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune bullous diseases characterized by the presence of tissue-bound and circulating autoantibodies directed against disease-specific target antigens ..
- Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrinS B Hopkinson
Northwestern University Medical School, Chicago, Illinois 60611, USA
J Cell Biol 130:117-25. 1995The 180-kD bullous pemphigoid autoantigen (BP180) is a component of the hemidesmosome, a cell-matrix connector...
- A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoidStefan Beissert
Department of Dermatology, Von Esmarch Strasse 58, D 48149 Munster, Germany
Arch Dermatol 143:1536-42. 2007To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine sodium or mycophenolate mofetil for the treatment of bullous pemphigoid.
- Bullous pemphigoid in infancy: Clinical and epidemiologic characteristicsOrith Waisbourd-Zinman
Pediatric Dermatology Unit, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
J Am Acad Dermatol 58:41-8. 2008Recent cases of infants with bullous pemphigoid (BP) prompted us to explore the clinical and laboratory features of childhood BP.
- Anti-bullous pemphigoid 180 and 230 antibodies in a sample of unaffected subjectsCarilyn N Wieland
Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Dermatol 146:21-5. 2010To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP.
- A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigenHideyuki Ujiie
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Immunol 184:2166-74. 2010b>Bullous pemphigoid (BP), the most common autoimmune blistering disease, is caused by autoantibodies against type XVII collagen (COL17)...
- A biological approach in a patient with psoriasis and bullous pemphigoid associated with losartan therapyR Saraceno
Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
Clin Exp Dermatol 33:154-5. 2008..cases of psoriasis associated with bullous disorders have been reported, and it is clearly recognized that bullous pemphigoid (BP) is the most common bullous disorder observed in association with psoriasis, especially after ..
- Childhood bullous pemphigoid following hepatitis B immunizationZulal Erbagci
Gaziantep University Medical Faculty, Department of Dermatology, Gaziantep, Turkey
J Dermatol 29:781-5. 2002b>Bullous pemphigoid (BP) is an acquired autoimmune bullous disorder which predominantly affects the elderly. It is very rare in children. There are approximately 50 reported cases of childhood BP...
- IgG autoantibody reactivity against bullous pemphigoid (BP) 180 and BP230 in elderly patients with pruritic dermatosesC Feliciani
Department of Dermatology and Allergology, Philipps University Marburg, 35039 Marburg, Germany
Br J Dermatol 161:306-12. 2009..Specifically, a prodromal phase of bullous pemphigoid (BP) has to be considered in patients with pruritic lesions of polymorphic appearance...
- The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control studyKathy Taghipour
Department of Dermatology, Oxford Radcliffe Hospitals, Old Road, Headington, Oxford OX3 7LJ, England
Arch Dermatol 146:1251-4. 2010To investigate the relationship between bullous pemphigoid (BP) and neurologic disease.
- Medication history of a series of patients with bullous pemphigoid from northern Greece - observations and discussionAikaterini Patsatsi
First Dermatologic Clinic and First Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Greece
Int J Dermatol 48:132-5. 2009b>Bullous pemphigoid (BP) is an autoimmune bullous disease that mainly affects elderly patients...
- BP230- and BP180-specific auto-antibodies in bullous pemphigoidSybille Thoma-Uszynski
Department of Dermatology, Friedrich Alexander University, Erlangen Nurnberg, Germany
J Invest Dermatol 122:1413-22. 2004b>Bullous pemphigoid is a subepidermal blistering disease associated with auto-antibodies (auto-ab) to BP180 and BP230...
- A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreadingJanet A Fairley
Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
J Am Acad Dermatol 51:118-22. 2004b>Bullous pemphigoid (BP) and epidermolysis bullosa acquisita are distinct autoimmune blistering disorders...
- Autoantibodies to human alpha6 integrin in patients with bullous pemphigoidMaria Kiss
Department of Dermatology and Allergology, University of Szeged, H 6720 Szeged, Koranyi fasor 6, Hungary
Ann N Y Acad Sci 1051:104-10. 2005b>Bullous pemphigoid (BP) is characterized immunologically by tissue-bound and circulating autoantibodies targeting the hemidesmosomal proteins BP230 and BP180...
- [Bullous pemphigoid in young patients: a retrospective study of 74 cases]E Bourdon-Lanoy
Service de Dermatologie, Hopital Henri Mondor, 94010 Creteil, France
Ann Dermatol Venereol 132:115-22. 2005b>Bullous pemphigoid usually affects elderly people. Only a few isolated cases among people younger than 65 years have been reported.
- Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formationY Hirako
Unit of Biosystems, Graduate School of Human Informatics, The Department of Molecular Biology, School of Science, Nagoya University, Chikusa ku, Nagoya 464 01, Japan
J Biol Chem 271:13739-45. 1996The 180-kDa bullous pemphigoid antigen (BP180) is a hemidesmosomal transmembrane glycoprotein comprising interrupted collagen domains in its extracellular part. BP180 is also termed type XVII collagen...
- Bullous pemphigoid as a dermadrome associated with spindle cell carcinoma of the gallbladderAyano Umekoji
Department of Dermatology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
J Dermatol 37:251-4. 2010Skin disorders that appear in association with internal malignancies are called dermadromes. Bullous pemphigoid (BP), which is a major autoimmune disease of the skin, is considered to be a dermadrome, although there have been conflicting ..
- Childhood bullous pemphigoid developed after the first vaccinationC Baykal
Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Turkey
J Am Acad Dermatol 44:348-50. 2001b>Bullous pemphigoid (BP) typically affects the elderly. There are at least 40 reported cases of BP in childhood, 10 reported cases at 1 year of age or younger. The antigen of this autoimmune disease is localized to the hemidesmosome...
- IgE antibodies in sera from patients with bullous pemphigoid are autoantibodies preferentially directed against the 230-kDa epidermal antigen (BP230)R F Ghohestani
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Clin Immunol 18:202-9. 1998b>Bullous pemphigoid (BP) is unique among autoimmune skin diseases in which a high serum IgE level has been detected...
- Pemphigus and bullous pemphigoidH C Nousari
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2196, USA
Lancet 354:667-72. 1999Pemphigus and bullous pemphigoid are distinct autoimmune blistering diseases that are characterised by the presence of autoantibodies directed against specific adhesion molecules of the skin and mucous membranes...
- Serological studies in bullous pemphigoid: a literature review of antibody titers at presentation and in clinical remissionStefania Leuci
Department of Odontostomatological and Maxillo Facial Sciences, Federico II University of Naples, Italy
Acta Derm Venereol 90:115-21. 2010b>Bullous pemphigoid is associated with antibodies to a 230 kDa and a 180 kDa protein. In a literature review we investigated the role of auto-antibodies as detected by different serological assays...
- Furosemide-induced bullous pemphigoid: case report and review of literatureJennifer J Lee
Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA
J Drugs Dermatol 5:562-4. 2006b>Bullous pemphigoid (BP) is an acquired autoimmune disease characterized by subepidermal vesicles and bullae...
- Development of a system for detection of circulating antibodies against hemidesmosomal proteins in patients with bullous pemphigoidS Husz
Department of Dermatology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
Arch Dermatol Res 292:217-24. 2000Specific antibodies directed against special hemidesmosomal proteins are involved in the pathogenesis of bullous pemphigoid (BP), and detection of these antibodies is crucial for a correct diagnosis...
- IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachmentHiroaki Iwata
Department of Dermatology, Gifu Graduate School of Medicine, Gifu, Japan
J Invest Dermatol 129:919-26. 2009We have shown that binding of bullous pemphigoid (BP)-patient IgG (BP-IgG) causes the internalization of BP180 from the cell membrane...
- Elevated levels of eotaxin and interleukin-5 in blister fluid of bullous pemphigoid: correlation with tissue eosinophiliaM Wakugawa
Department of Dermatology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Br J Dermatol 143:112-6. 2000b>Bullous pemphigoid (BP) often provokes blood and tissue eosinophilia, which suggests that some chemoattractants modulate the eosinophil infiltration in BP...
- The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expressionB Favre
Department of Dermatology, University Medical School, 1211 Geneva 14, Switzerland
J Biol Chem 276:32427-36. 2001The bullous pemphigoid antigen 1 (eBPAG1) is a constituent of hemidesmosomes (HDs), cell-substrate adhesion complexes in stratified epithelia...
- A highly sensitive and simple assay for the detection of circulating autoantibodies against full-length bullous pemphigoid antigen 180Enno Schmidt
Department of Biotechnology, Biocenter, University of Wurzburg, Wurzburg, Germany
J Autoimmun 18:299-309. 2002b>Bullous pemphigoid antigen 180 (BP180) is the target of autoantibodies in various subepidermal blistering diseases. The most common one is bullous pemphigoid (BP)...
- Utility of an interferon-gamma release assay for latent tuberculosis diagnosis in a case of bullous pemphigoidAlfred Goodfellow
Department of Dermatology Department of Infectious Disease, Saint John Regional Hospital, Saint John, NB
J Cutan Med Surg 13:280-2. 2009..Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed...
- Furosemide-induced bullous pemphigoidK Baz
J Eur Acad Dermatol Venereol 16:81-2. 2002
- Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoidNobuko Ishiura
Department of Dermatology, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
J Dermatol Sci 49:153-61. 2008b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins, BP180 and BP230...
- A case of bullous pemphigoid arising in juvenile hyaline fibromatosis with oral squamous cell carcinomaKazuhiro Shimizu
Department of Dermatology, Nagasaki University, Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, 852 8501 Nagasaki, Japan
J Dermatol 32:650-3. 2005We experienced a case of bullous pemphigoid (BP) arising in juvenile hyaline fibromatosis (JHF) associated with oral squamous cell carcinoma (SCC). JHF is a very rare disease inherited in an autosomal recessive fashion...
- Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgarisM J Rico
Dermatology Service, New York VA Medical Center and Department of Dermatology, New York University, 423 East 23rd Street, New York, NY 10010, USA
Br J Dermatol 140:1079-86. 1999..cell marker expression in perilesional skin biopsies from patients with the autoimmune blistering diseases bullous pemphigoid (BP, n = 21) and pemphigus vulgaris (PV, n = 7)...
- A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoidKelly A N Messingham
The Department of Dermatology, University of Iowa, Iowa City, IA, USA
J Immunol Methods 346:18-25. 2009b>Bullous pemphigoid (BP) is a humoral autoimmune disease directed predominantly against the non-collagenous NC16A domain of the BP180 hemidesmosomal protein...
- Ectodomain shedding generates Neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoidWataru Nishie
Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
J Immunol 185:4938-47. 2010..Correspondingly, neoepitopes were found in the skin and blister fluids of patients with bullous pemphigoid, and bullous pemphigoid sera reacted with the peptide Leu(524)-Gly(532)...
- Human bullous pemphigoid antigen 2 transgenic skin elicits specific IgG in wild-type miceEdit B Olasz
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Invest Dermatol 127:2807-17. 2007b>Bullous pemphigoid antigen 2 (BPAG2) is targeted by autoantibodies in patients with bullous pemphigoid (BP), and absent in patients with one type of epidermolysis bullosa (OMIM #226650)...
- A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu miceJanet A Fairley
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Invest Dermatol 127:2605-11. 2007b>Bullous pemphigoid (BP) is an autoimmune disease characterized by subepidermal blistering. Based on previous work, IgG autoantibodies directed against BP180 are thought to be the primary pathogenic agent in BP...
- Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptideY Hirako
Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya 464 01
J Biol Chem 273:9711-7. 1998..One of the putative cell-matrix adhesion molecules present in the HD is the 180-kDa bullous pemphigoid antigen (BP180), also termed type XVII collagen...
- Bullous pemphigoid autoantibodies preferentially recognize phosphoepitopes in collagen XVIIElena P Zimina
J Invest Dermatol 128:2736-9. 2008
- Minocycline as a therapeutic option in bullous pemphigoidW J Loo
Department of Dermatology, The Churchill, Oxford Radcliffe Hospital, Headington, Oxford, UK
Clin Exp Dermatol 26:376-9. 2001We present a retrospective analysis of patients with bullous pemphigoid (BP) treated with minocycline in the Department of Dermatology, Churchill Hospital, Oxford between July 1986 and May 2000...
- Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoidJanet A Fairley
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Invest Dermatol 125:467-72. 2005b>Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal protein BP180 (BPAg2, type XVII collagen)...
- The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1A Brown
Institut du Cancer de Montreal, Centre de Recherche L C Simard, Quebec, Canada
Nat Genet 10:301-6. 1995..encodes an N-terminal actin binding domain and a C-terminal portion comprised of the hemidesmosomal protein, bullous pemphigoid antigen 1 (bpag1)...
- Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicityTanya N Mayadas; Fiscal Year: 2013..and 5) demonstrate a critical role for Mac-1 on neutrophils in two additional complement dependent models, bullous pemphigoid and thrombotic glomerulonephritis. The current application builds on these discoveries...
- Syk blockade in bullous skin diseasesUma Sinha; Fiscal Year: 2012DESCRIPTION (provided by applicant): Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and is associated with significant morbidity and mortality...
- The Role of IgE in Autoimmune Skin DiseasesJanet A Fairley; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bullous pemphigoid (BP) is a blistering disease of the skin characterized by development of autoantibodies directed against BP180, a cell-substrate attachment protein...
- Innate Immunity in Bullous PemphigoidZhi Liu; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by autoantibodies and an inflammatory infiltrate at the lesional site...
- IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOIDZhi Liu; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by autoantibodies and an inflammatory infiltrate at the lesional site...
- Coordinated cytoskeletal dynamics in skin somatic stem cells - Resubmission 01Xiaoyang Wu; Fiscal Year: 2013..Our preliminary results revealed a critical function of ACF7 and its paralog BPAG1 (Bullous Pemphigoid Antigen 1) in coordinating cytoskeletal dynamics and transmitting the Wnt signals in skin SSCs...
- Keratinocyte Migration and Wound HealingJonathan C Jones; Fiscal Year: 2013..Aim 2 is premised on preliminary data indicating that the Bullous Pemphigoid Antigen 2 (BPAG2) regulates keratinocyte migration/wound healing by mediating BPAG1e interaction with 1624 ..
- PATHOPHYSIOLOGY OF EXPERIMENTALLY INDUCED PEMPHIGUSGrant Anhalt; Fiscal Year: 1993..2) the 250 KD Ag is desmoplakin 1 - a demonstrated plaque protein - and the 230 KD Ag is the 230 KD bullous pemphigoid Ag a hemidesmosomal protein; (3) the autoantibodies from these patients cause cutaneous and esophageal ..
- Mechanism of neurodegeneration in dystonia musculorumRONALD LIEM; Fiscal Year: 2007..The gene that is mutated in dt mice is called dystonin, and is also known as bullous pemphigoid antigen 1 (BPAG1). BPAG1 is a member of the plakin family of cytoskeletal linker proteins...
- HERPES GESTATIONIS ANTIGEN/AUTOANTIBODY SYSTEMLynne Morrison; Fiscal Year: 1993..It has been proposed that HG is related to bullous pemphigoid, another blistering dermatosis occurring in elderly patients, based on similar morphologic, histologic and ..
- PEMPHIGUS AND PEMPHIGOIDLuis Diaz; Fiscal Year: 1999..In Bullous Pemphigoid (BP) we have demonstrated that: f) BP autoantibodies recognize hemidesmosomal antigens...
- EPITHELIALIZATION OF TISSUE ENGINEERED CORNEASJEAN JACOB; Fiscal Year: 2003..and F-actin, jet impingement to determine cellular adhesion, and immunohistochemistry for laminin, bullous pemphigoid antigen, and collagen VII...
- HEMIDESMOSOMES IN BULLOUS PEMPHIGOIDGEORGE GIUDICE; Fiscal Year: 2007..an autoimmune response directed against the BP180 protein is a key initiatory step in the pathogenesis of bullous pemphigoid and several other acquired blistering diseases...
- PATHOGENICITY OF PEMPHIGUS AND PEMPHIGOID ANTIBODIESGrant Anhalt; Fiscal Year: 1991..b>Bullous pemphigoid (BP) is another cutaneous blistering disease in which autoantibodies are present...
- THE IMMUNOPATHOLOGY OF PEMPHIGUS AND BULLOUS PEMPHIGOIDRobert Jordon; Fiscal Year: 1990The objectives are to continue to investigate immunopathogenic mechanisms in pemphigus and bullous pemphigoid. We have recently presented evidence that complement is fixed to epidermal cell surfaces by pemphigus antibody, that complement ..
- HUMAN SKIN MAST CELL GRANULE ENZYMES--SKIN DISEASESBRUCE WINTROUB; Fiscal Year: 1992..Finally, the deposition of mast cell granule carboxypeptidase will be examined in vivo in diseases marked by increased vascular permeability, i.e. cold urticaria, and by tissue destruction, i.e. bullous pemphigoid.
- HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEMSirpa Aho; Fiscal Year: 2002..the yeast two-hybrid system to reveal the hemidesmosomal network of proteins Centering on the 180-kD bullous pemphigoid antigen (BPAG2/BP180), a transmembrane molecule also known as a type XVI Collagen...
- AN IN VITRO MODEL OF BULLOUS PEMPHIGOIDWALTER GAMMON; Fiscal Year: 1993....
- INTERDISCIPLINARY RESEARCH IN IMMUNOLOGIC DISEASESPhillip Norman; Fiscal Year: 1990..Individual projects propose to study: 1. Mediator release in inflammatory bowel disease, 2. Proteases in bullous pemphigoid and chronic urticaria, 3. Mechanisms of anti-inflammatory actions of corticosteroids, 4...
- Antigen specific therapy for bullous pemphigoidFrancoise Van den Bergh; Fiscal Year: 2009DESCRIPTION (provided by applicant): Bullous Pemphigoid (BP) is an autoimmune blistering skin disease...
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..proposal, we will focus on three clinical entities: pemphigus foliaceus (PF), pemphigus vulgaris (PV), and bullous pemphigoid (BP)...
- Comparative In Vivo Biodistribution of Characterized Manufactured NanomaterialsNancy A Monteiro Riviere; Fiscal Year: 2010..These coordinated studies will provide data to link physical chemical characterizations to in vivo MNM disposition. ..
- Mechanism of Keratinocyte MotilityDavid Woodley; Fiscal Year: 2009..Lastly, in our Third Aim, we will develop a novel animal model to examine the veracity of our in vitro data. This model will consist of genetically engineered human skin equivalents grafted onto hairless mice. ..
- Dendritic Cell-Based Biosensor SystemAkira Takashima; Fiscal Year: 2005..Our study wil provide new insights into DC biology and may lead to the development of novel adjuvants and therapeutics. ..
- T CELL DEPENDENT TERMINAL MATURATION OF LANGERHANS CELLSAkira Takashima; Fiscal Year: 2005....
- A Transgenic Animal Model for PemphigoidKIM YANCEY; Fiscal Year: 2007..b>Bullous pemphigoid antigen 2 (BPAG2), a type II transmembrane protein in hemidesmosomes, is a major autoantigen bound by such ..
- Anti-angiogenic signaling molecules in retinal cellsNader Rahimi; Fiscal Year: 2004..our long-term goal is to begin to apply the information obtained from this project to the design of strategies to regulate angiogenesis in clinical settings. ..
- VEGFR-1 and VEGFR-2 in angiogenesisNader Rahimi; Fiscal Year: 2006..Once we determine the mechanism by which VEGF receptors are engaged it will be possible to attenuate the angiogenic signal transduction relay by developing targeted therapeutic interventions aimed at angiogenesis suppression ..
- Functions of BPAG1nYanmin Yang; Fiscal Year: 2006..The Department of Neurology at Stanford University provides an ideal environment for developing my academic career into a leading investigator in the neurobiology of disease. ..
- Characterizing BPAG1n4, a Sensory Neuron's SustainerYanmin Yang; Fiscal Year: 2006..Our findings wilt lead to a better understanding and possible treatment for neurodegenerative disorders. ..
- LANGERHANS CELL TARGETED GENETIC VACCINE AGAINST HIV1Akira Takashima; Fiscal Year: 2002....
- BIOLOGY OF THE THY-1 ANTIGEN BEARING EPIDERMAL CELLSAkira Takashima; Fiscal Year: 2002..Through these five specific aims they intend to uncover unique activities of IL-13 in the skin. ..
- ANTIGEN IMMUNOSUPPRESSION BY KILLER LANGERHANS CELLSAkira Takashima; Fiscal Year: 2004..g., haptens, allergens, autoantigens, and alloantigens). ..
- CELLULAR IMMUNE RESPONSES IN PEMPHIGUS VULGARISMong Shang Lin; Fiscal Year: 2003....
- POLYVALENT VACCINE IN IL-2+GM-CSF LIPOSOMES FOR MELANOMAJean Claude Bystryn; Fiscal Year: 2004..More broadly, it may provide a general method of potentiating the immunogenicity of vaccines against other cancers and to infectious diseases. ..
- PEMPHIGUS 2005-PROGRESS AND FUTURE DIRECTIONSJean Claude Bystryn; Fiscal Year: 2005..We expect it will attract 100-150 scientists and clinicians dedicated to investigate and treating pemphigus. ..
- Role of Protein Ubiquitination in AngiogenesisNader Rahimi; Fiscal Year: 2010..Identification of molecules that inhibit the angiogenic signaling of VEGFR-2 will provide new avenues for development of better and more effective agents to combat angiogenesis-associated diseases. ..
- Behavioral dynamics of Langerhans cells in skinAkira Takashima; Fiscal Year: 2010..Our study should provide important insights into the behavioral biology of LCs and the pathophysiology of skin disease in which LCs play pathogenic or protective roles. ..
- Strategies Towards Gene Therapy for Dystrophic Epidermolysis BullosaMei Chen; Fiscal Year: 2009..We believe the proposed experiments will give us sufficient information to consider clinical protocols for humans, the long-term goal of this work. ..
- TRAINING GRANT IN DERMATOLOGICAL RESEARCHLuis Diaz; Fiscal Year: 2006..This competitive grant application requests funding to support the training at the UNC Dermatology Department of the next generation of dermatological investigators. ..
- Nitric Oxide Metabolism in Statin-treated Pediatric SLEMARC LEVESQUE; Fiscal Year: 2006..In addition, these DNA samples will constitute an important resource for future genetic analyses of pediatric SLE. [unreadable] [unreadable] [unreadable]..
- SERUM CYT-MAA AS AN EARLY MARKER OF RESPONSE TO THERAPY IN RESECTED MELANOMAJean Claude Bystryn; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..