autoimmune diseases

Summary

Summary: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Top Publications

  1. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  2. pmc Unraveling the genetics of autoimmunity
    Lauren A Zenewicz
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Cell 140:791-7. 2010
  3. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
  4. ncbi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
  5. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  6. ncbi Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Nat Immunol 11:7-13. 2010
  7. pmc IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    David Yen
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1310-6. 2006
  8. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
  9. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
  10. pmc Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    Yohei Iwata
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Blood 117:530-41. 2011

Detail Information

Publications318 found, 100 shown here

  1. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  2. pmc Unraveling the genetics of autoimmunity
    Lauren A Zenewicz
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Cell 140:791-7. 2010
    The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases...
  3. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  4. ncbi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..However, in some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate ..
  5. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  6. ncbi Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Nat Immunol 11:7-13. 2010
    ....
  7. pmc IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    David Yen
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1310-6. 2006
    ..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
  8. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..athymic nude (nu/nu) mice, all recipients spontaneously developed histologically and serologically evident autoimmune diseases (such as thyroiditis, gastritis, insulitis, sialoadenitis, adrenalitis, oophoritis, glomerulonephritis, and ..
  9. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..This hypothesis proved correct. The mutant animals exhibited a defined profile of autoimmune diseases that depended on the absence of aire in stromal cells of the thymus...
  10. pmc Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    Yohei Iwata
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Blood 117:530-41. 2011
    ..The characterization of human B10 cells will facilitate their identification and the study of their regulatory activities during human disease...
  11. ncbi Human FoxP3+ regulatory T cells in systemic autoimmune diseases
    Makoto Miyara
    Internal Medicine Department, French national Reference center for SLE and antiphospholipid syndrome AP HP Hôpital Pitié Salpêtrière, 75013 Paris, France
    Autoimmun Rev 10:744-55. 2011
    ..of differentiation of Treg cells should bring new insights in the understanding of human chronic systemic autoimmune diseases. How Treg cells are compromised in these diseases is a challenging issue because the elucidation of the ..
  12. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases. Coronary heart disease, major depression, aging and cancer are characterized by an increased level of ..
  13. pmc Pervasive sharing of genetic effects in autoimmune disease
    Chris Cotsapas
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002254. 2011
    ..We are thus able to leverage genetic data across diseases to construct biological hypotheses about the underlying mechanism of pathogenesis...
  14. ncbi TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    Ahjoku Amadi-Obi
    Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 13:711-8. 2007
    ....
  15. pmc Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases
    Xiaoyu Hu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Immunity 31:539-50. 2009
    ..mechanisms reveal insights about how IFN-gamma regulates macrophage activation, inflammation, tissue remodeling, and helper and regulatory T cell differentiation and how Th1 and Th17 cell responses are integrated in autoimmune diseases.
  16. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  17. pmc The type I interferon system in the etiopathogenesis of autoimmune diseases
    Lars Rönnblom
    Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 116:227-37. 2011
    Many patients with systemic autoimmune diseases have signs of a continuous production of type I interferon (IFN) and display an increased expression of IFN-α-regulated genes...
  18. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
    ..of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis...
  19. ncbi Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    Hui Chen Hsu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 9:166-75. 2008
    ..These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs...
  20. ncbi T(H)-17 cells in the circle of immunity and autoimmunity
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:345-50. 2007
    ..Emerging data regarding T(H)-17 cells suggest a very important function for this T cell subset in immunity and disease...
  21. ncbi Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 102:1646-53. 2007
    ..To determine the sensitivity and specificity of elevated serum IgG4 level for the diagnosis of autoimmune pancreatitis (AIP) and its ability to distinguish AIP from pancreatic cancer, its main differential diagnosis...
  22. ncbi Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1010-6; quiz 934. 2006
    ..AIP has unique histologic features associated with infiltration of tissues of affected organs with abundant IgG4-positive cells. We propose expanded diagnostic criteria for AIP with a cohort of histologically confirmed AIP...
  23. ncbi Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis
    Makoto Otsuki
    Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    J Gastroenterol 43:403-8. 2008
    ..A diagnostic trial of steroid therapy can be applied carefully by expert pancreatologists only in patients fulfilling criterion I alone with negative diagnostic work-up results for pancreatobiliary cancer...
  24. pmc A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease
    Motohisa Yamamoto
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Mod Rheumatol 16:335-40. 2006
    ..Mikulicz's disease thus differs from SS and may be a systemic IgG4-related plasmacytic disease...
  25. pmc The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    B Afzali
    Department of Nephrology and Transplantation, King s College London, Guy s and St Thomas Hospital, UK
    Clin Exp Immunol 148:32-46. 2007
    ..the importance of interferon (IFN)-gamma and IL-17 in the development and progression of inflammatory and autoimmune diseases (AD)...
  26. ncbi International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 40:352-8. 2011
    ..To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP)...
  27. pmc The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
    Helena Tlaskalova-Hogenova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
    Cell Mol Immunol 8:110-20. 2011
    ..g., probiotics and prebiotics) whose administration may aid in disease prevention and treatment...
  28. pmc Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases
    Jane Hoyt Buckner
    Translational Research Program, Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101, USA
    Nat Rev Immunol 10:849-59. 2010
    ..This Review summarizes our progress so far towards understanding the role of CD4(+)CD25(+)FOXP3(+) T(Reg) cells in human autoimmune diseases and the impact that this knowledge might have on the diagnosis and treatment of these diseases.
  29. ncbi Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature
    Antonio Antico
    Laboratorio di Patologia Clinica, Ospedale Civile, Cittadella, Italy
    Autoimmun Rev 12:127-36. 2012
    To evaluate whether vitamin D levels are related to the risk of developing autoimmune diseases and whether supplementation with vitamin D can modify the course of the diseases.
  30. pmc From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
    Vinod Kumar
    Department of Genetics, University Medical Hospital Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Semin Immunopathol 34:567-80. 2012
    ..We also present novel approaches to identifying the causal variants in complex susceptibility loci and disease mechanisms...
  31. ncbi Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?
    Karen H Costenbader
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA
    Autoimmun Rev 11:604-9. 2012
    b>Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and inflammatory bowel disease, have complex pathogeneses and likely multifactorial etiologies...
  32. ncbi Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis...
  33. ncbi Interleukin-21: basic biology and implications for cancer and autoimmunity
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
    Annu Rev Immunol 26:57-79. 2008
    ..The key to harnessing the power of IL-21 will depend on better understanding its range of biological actions, its mechanism of action, and the molecular basis of regulation of expression of IL-21 and its receptor...
  34. ncbi A new clinicopathological entity of IgG4-related autoimmune disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    J Gastroenterol 38:982-4. 2003
    Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
  35. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    ..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
  36. ncbi Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    H Nishimura
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
    Science 291:319-22. 2001
    ..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.
  37. ncbi Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nat Immunol 6:345-52. 2005
    ..They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens...
  38. ncbi Not always the bad guys: B cells as regulators of autoimmune pathology
    Simon Fillatreau
    Simon Fillatreau is at the Immune regulation group, Deutsches Rheuma ForschungsZentrum, Chariteplatz 1, 10117 Berlin, Germany
    Nat Rev Immunol 8:391-7. 2008
    ..It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses...
  39. ncbi Modes of action of Freund's adjuvants in experimental models of autoimmune diseases
    A Billiau
    Rega Institute, University of Leuven, Belgium
    J Leukoc Biol 70:849-60. 2001
    ..Thus, in experimental autoimmune diseases, CFA-mediated activation of the innate immune compartment is important not only by regulating the early ..
  40. pmc Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers
    Gordan Lauc
    Glycobiology Laboratory, Genos, Zagreb, Croatia
    PLoS Genet 9:e1003225. 2013
    ..The results may also provide an explanation for the reported pleiotropy and antagonistic effects of loci involved in autoimmune diseases and haematological cancer.
  41. ncbi Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Annu Rev Immunol 22:531-62. 2004
    ....
  42. pmc Autoimmune diseases, bipolar disorder, and non-affective psychosis
    William W Eaton
    Department of Mental Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Bipolar Disord 12:638-46. 2010
    Clinic-based studies of immune function, as well as comorbidity of autoimmune diseases, bipolar disorder, and schizophrenia, suggest a possible autoimmune etiology...
  43. pmc MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
    Rujuan Dai
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0342, USA
    Transl Res 157:163-79. 2011
    ..patterns now have been documented in a broad range of diseases including cancer as well as inflammatory and autoimmune diseases. This rapidly emerging field has revolutionized our understanding of normal immunoregulation and breakdown ..
  44. ncbi Hygiene hypothesis and autoimmune diseases
    Graham A W Rook
    Department of Infection, Centre for Clinical Microbiology, University College London UCL, London, UK
    Clin Rev Allergy Immunol 42:5-15. 2012
    ....
  45. ncbi Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases
    Eyal Ben-Ami
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Autoimmun Rev 10:410-5. 2011
    ..immunomodulatory capabilities of the MSCs, the possible mechanisms underlying these functions and presents the potential of using this stem cell-based approach as an immunomodulatory tool for the treatment of autoimmune diseases.
  46. ncbi Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease
    Kazuichi Okazaki
    Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Shinmachi, Hirakata, Osaka 573 1197, Japan
    J Gastroenterol 46:277-88. 2011
    ..The concept and diagnostic criteria of "IgG4-related disease" will be changed in accordance with future studies...
  47. ncbi The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
    A Alcina
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas CSIC, Granada, Spain
    Genes Immun 11:439-45. 2010
    ..These data may help to shape the contribution of each pathway to different disorders...
  48. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  49. ncbi Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer
    Alessio Fasano
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Physiol Rev 91:151-75. 2011
    ..This review is timely given the increased interest in the role of a "leaky gut" in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs...
  50. pmc Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases
    Juan Manuel Anaya
    Center for Autoimmune Diseases Research CREA, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 11:276-80. 2012
    Many autoimmune diseases (ADs) share similar underlying pathology and have a tendency to cluster within families, supporting the involvement of shared susceptibility genes...
  51. ncbi Shared genetics in coeliac disease and other immune-mediated diseases
    J Gutierrez-Achury
    Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands
    J Intern Med 269:591-603. 2011
    ..Follow-up of individuals with a high genetic risk of CD and other autoimmune diseases could help to elucidate the role of environmental factors (such as infectious agents or alterations in the ..
  52. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    ..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
  53. ncbi Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease
    Arezou Khosroshahi
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1755-62. 2010
    ..This study was performed to assess the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients with IgG4-RSD...
  54. ncbi Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease
    Reiko Akitake
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Gut 59:542-5. 2010
    ....
  55. ncbi TNF receptor 2 pathway: drug target for autoimmune diseases
    Denise Faustman
    Immunobiology Laboratory, Room 3602, Building 149, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Drug Discov 9:482-93. 2010
    Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells...
  56. ncbi IgG4-related disease: a cross-sectional study of 114 cases
    Yoh Zen
    Institute of Liver Studies, King s College Hospital, London, UK
    Am J Surg Pathol 34:1812-9. 2010
    ..Further study is necessary to conclude whether these features reflect different manifestations of a single disease entity or suggest different underlying etiologic factors...
  57. pmc Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo, 113 8677, Japan
    J Gastroenterol 41:613-25. 2006
    ..We propose a new clinicopathological entity, "IgG4-related sclerosing disease", and suggest that AIP is a pancreatic lesion reflecting this systemic disease...
  58. pmc Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal
    Kazuichi Okazaki
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    J Gastroenterol 41:626-31. 2006
  59. ncbi Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:706-15. 2008
    ..We describe clinical features, treatment response, and predictors of relapse in IAC and compare relapse rates in IAC with intrapancreatic vs proximal bile duct strictures...
  60. ncbi Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis
    Yoko Uchiyama-Tanaka
    Department of Medicine II, Kansai Medical University, Osaka, Japan
    Am J Kidney Dis 43:e18-25. 2004
    ..To our knowledge, this is the first report of acute TIN associated with AIP. We suggest that AIP may be an etiologic factor in some cases of TIN...
  61. ncbi Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takarama chi, Kanazawa 920 8640, Japan
    Hepatology 45:1538-46. 2007
    ..CONCLUSION: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs...
  62. pmc Autoimmune diseases: insights from genome-wide association studies
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Hum Mol Genet 17:R116-21. 2008
    b>Autoimmune diseases occur when an individual's own immune system attacks and destroys his or her healthy cells and tissues...
  63. ncbi Immunomodulation by mesenchymal stem cells and clinical experience
    K Le Blanc
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 262:509-25. 2007
    ..Possible clinical applications include therapy-resistant severe acute graft-versus-host disease, tissue repair, treatment of rejection of organ allografts and autoimmune disorders...
  64. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
    ..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
  65. pmc A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
    Paula S Ramos
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS Genet 7:e1002406. 2011
    ..analyses of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) and other autoimmune diseases (ADs) have been limited...
  66. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  67. ncbi Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    Ilia J Elenkov
    Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 966:290-303. 2002
    ..of chronic stress, severe exercise, and pregnancy and the postpartum period, through modulation of the systemic or local pro/antiinflammatory cytokine balance, may suppress or potentiate autoimmune diseases activity and/or progression.
  68. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  69. ncbi IgG4-related disease: historical overview and pathology of hematological disorders
    Yasuharu Sato
    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Pathol Int 60:247-58. 2010
    ..Moreover, some malignant lymphomas, especially mucosa-associated lymphoid tissue lymphoma, arise from ocular adnexal IgG4-related disease. In addition, IgG4-producing lymphoma also exists...
  70. ncbi Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:471-7. 2010
    ..It is unclear whether the long-term outcome is good because there are many unknown factors, such as relapse, pancreatic exocrine or endocrine dysfunction, and associated malignancy...
  71. ncbi CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    Thomas R Malek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Immunity 17:167-78. 2002
    ..These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4(+)CD25(+) regulatory T cells...
  72. ncbi Implication of human endogenous retroviruses in the development of autoimmune diseases
    Eva Balada
    Research Unit in Systemic Autoimmune Diseases, Vall d Hebron Research Institute, Barcelona, Spain
    Int Rev Immunol 29:351-70. 2010
    ..Some medical conditions, such as cancer and autoimmune diseases, are linked to the transcription of some of the HERVs genes, to the expression of HERVs proteins (that may ..
  73. pmc Dendritic cells and cytokines in human inflammatory and autoimmune diseases
    Patrick Blanco
    CHU Bordeaux, 33076 Bordeaux, France
    Cytokine Growth Factor Rev 19:41-52. 2008
    ..and associated alterations in DC homeostasis have been implicated in various human inflammatory and autoimmune diseases. Targeting these cytokines with biological agents as already is the case with TNF and IL-1 represents a ..
  74. pmc Biologic therapy for autoimmune diseases: an update
    Ziv Rosman
    Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, POB 63, Holon, 58100 Israel
    BMC Med 11:88. 2013
    ....
  75. pmc Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop
    Frederick W Miller
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health Clinical Research Center, Bethesda, MD 20892 1301, USA
    J Autoimmun 39:259-71. 2012
    b>Autoimmune diseases (AID) are a collection of many complex disorders of unknown etiology resulting in immune responses to self-antigens and are thought to result from interactions between genetic and environmental factors...
  76. pmc B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice
    Lino L Teichmann
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06519, USA
    J Immunol 188:678-85. 2012
    ....
  77. ncbi ANA screening: an old test with new recommendations
    Pier Luigi Meroni
    Division of Rheumatology, Department of Internal Medicine, Istituto G Pini, University of Milan and IRCCS Istituto Auxologico Italiano, Milan, Italy
    Ann Rheum Dis 69:1420-2. 2010
    The impact of autoimmune diseases is growing from both a clinical and a laboratory point of view. Diagnostic assays are now being transferred from dedicated specialised laboratories into high-throughput service laboratories...
  78. pmc Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases
    Christine Beeton
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Inflamm Allergy Drug Targets 10:313-21. 2011
    CCR7- effector memory T (TEM) lymphocytes are involved in autoimmune diseases such as multiple sclerosis, type 1 diabetes mellitus and rheumatoid arthritis. These cells express Kv1...
  79. ncbi Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Verona, Italy
    Virchows Arch 445:552-63. 2004
    ..Our intention was to establish key diagnostic criteria, define grades of severity and activity, identify features of potential subtypes and evaluate the diagnostic relevance of biopsy specimens...
  80. ncbi Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis
    Narsing A Rao
    Doheny Eye Institute, Keck School of Mewdicine, University of Southern California, Los Angeles, CA 90033, USA
    Invest Ophthalmol Vis Sci 49:1161-71. 2008
    ..However, no apoptosis has been detected during this phase. In this study, alphaA-crystallin upregulation in the retina and its antiapoptotic protective role were evaluated in early EAU...
  81. ncbi Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus document
    Suresh T Chari
    Mayo Clinic, Rochester, MN, USA
    Pancreas 39:549-54. 2010
    ..Whereas most experts agreed that the entities should be referred to as type 1 and type 2 AIP, respectively, others had concerns regarding use of the term "autoimmune" to describe IDCP...
  82. pmc Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases
    Carlos G Grijalva
    Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave S, Ste 2600, The Village at Vanderbilt, Nashville, TN 37212, USA
    JAMA 306:2331-9. 2011
    ..Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete...
  83. pmc Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
    Terry J Smith
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Pharmacol Rev 62:199-236. 2010
    ..IGF-I/IGF-IR signaling may also participate in the pathogenesis of autoimmune diseases, although its relationship with these processes seems complex and relatively unexplored...
  84. pmc Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:405-14. 2008
    ..This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region...
  85. ncbi Epstein-Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary report
    O Barzilai
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:567-77. 2007
    To date, it is believed that the origin of autoimmune diseases is one of a multifactorial background...
  86. ncbi Interferon beta inhibits the Th17 cell-mediated autoimmune response in patients with relapsing-remitting multiple sclerosis
    Xin Zhang
    Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Neurol Neurosurg 112:641-5. 2010
    ..Our results have identified novel therapeutic mechanisms of IFNbeta, which inhibit Th17 cell differentiation in the context of the autoimmune response in MS...
  87. ncbi Autoimmune inflammation from the Th17 perspective
    Janette Furuzawa-Carballeda
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15 Tlalpan, Mexico City 14000, Mexico
    Autoimmun Rev 6:169-75. 2007
    ..arthritis (CIA), while knockout mice for the Th1 cytokine IL-12 (p35-/-) strongly develop both autoimmune diseases. Disease resistance by IL-23 knockout mice correlates well with the absence of IL-17-producing CD4(+) T ..
  88. ncbi Detecting shared pathogenesis from the shared genetics of immune-related diseases
    Alexandra Zhernakova
    Department of Medical Genetics, University Medical Centre Utrecht, Utrecht 3508 AB, The Netherlands
    Nat Rev Genet 10:43-55. 2009
    ..This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases...
  89. ncbi The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
    David A Copland
    Academic Unit of Ophthalmology, Department of Clinical Sciences at South Bristol, UK
    Invest Ophthalmol Vis Sci 49:5458-65. 2008
    ....
  90. ncbi A novel automated indirect immunofluorescence autoantibody evaluation
    Shaye Kivity
    The Zabludowicz Center for Autoimmune Diseases, Tel Aviv University, Tel Aviv, Israel
    Clin Rheumatol 31:503-9. 2012
    ..antinuclear (ANAs) and anticytoplasmatic antibodies (ACyA), are essential diagnosing markers for several autoimmune diseases. The current gold standard method for ANA detection is manual indirect immunofluorescence (IIF) on human ..
  91. pmc Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    T Takahashi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 192:303-10. 2000
    ..of CTLA-4 for a limited period in normal mice leads to spontaneous development of chronic organ-specific autoimmune diseases, which are immunopathologically similar to human counterparts...
  92. pmc Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
    Victor Chi
    Department of Physiology and Biophysics, UC Irvine, Irvine, CA 92697, USA
    Toxicon 59:529-46. 2012
    ..3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011...
  93. ncbi Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity
    Arthur M Krieg
    Coley Pharmaceutical Group Inc, Wellesley, MA, USA
    Immunol Rev 220:251-69. 2007
    ..TLRs may face an extra challenge to induce anti-pathogen immune responses while avoiding the induction of autoimmune diseases. With the rapid growth in understanding of the biology of the TLRs has come an increasing awareness of ..
  94. ncbi Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California Irvine, Irvine, CA 92697 4561, USA
    Mol Pharmacol 67:1369-81. 2005
    ..of autoreactive effector memory T (T(EM)) cells that play a major role in the pathogenesis of autoimmune diseases. We describe the characterization of the novel peptide ShK(L5) that contains l-phosphotyrosine linked via a ..
  95. ncbi Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases
    Karl Egerer
    Department of Rheumatology and Clinical Immunology, Institute of Biochemistry, Humboldt University of Berlin, Berlin, Germany
    J Rheumatol 29:2045-52. 2002
    ..cytosolic generation of MHC class I restricted antigens, and it represents an abundant antigen in several autoimmune diseases. To investigate the effects of autoimmune inflammatory and perioperative traumatic cellular damage, we ..
  96. ncbi B-cell targeted therapies in human autoimmune diseases: an updated perspective
    Michael J Townsend
    ITGR Biomarker Discovery Group, Genentech, South San Francisco, CA 94080, USA
    Immunol Rev 237:264-83. 2010
    ..In this review, we first discuss the role of B cells in driving autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, and Sjögren's syndrome, ..
  97. ncbi Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity
    Honorio Torres-Aguilar
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Autoimmun Rev 10:8-17. 2010
    ..in the balance between tolerogenic and immunogenic functions of DCs and instigate the development of autoimmune diseases (ADs). Therefore, in recent years, DCs have emerged as therapeutic targets to control of ADs...
  98. ncbi Coeliac disease, autoimmune diseases and gluten exposure
    Mervi Viljamaa
    Department of Internal Medicine, Tampere University Hospital, Finland
    Scand J Gastroenterol 40:437-43. 2005
    Gluten-free diet treatment has been proposed to prevent the development of autoimmune diseases in coeliac subjects...
  99. ncbi Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis
    Hideaki Miyoshi
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    Pancreas 36:133-40. 2008
    ..Recently, regulatory T cells (Tregs) have been reported to be involved in the development of various autoimmune diseases as well as B cell shifting to IgG4-producing plasmacytes...
  100. ncbi Infections and autoimmunity--friends or foes?
    Shaye Kivity
    Center for Autoimmune Diseases, Department of Medicine A and C, Sheba Medical Center, Tel Hashomer 52662, Israel
    Trends Immunol 30:409-14. 2009
    ..The development of an autoimmune disease after infection tends to occur in genetically susceptible individuals. By contrast, some infections can protect individuals from specific autoimmune diseases (i.e. the hygiene hypothesis).
  101. ncbi Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease
    Lynn D Cornell
    Departments of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1586-97. 2007
    ....

Research Grants67

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Background: - Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Background: - Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis...
  3. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..Furthermore, cancers, Rheumatoid Arthritis (RA) and other autoimmune diseases are prevalent in the aging VA population...
  4. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ..Because epigenetic alterations may be important etiologic components of autoimmune diseases, and St6galnac6 expression appears to play a key role in early inflammatory reactions, in Aim 3 we will ..
  5. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..Histamine is a potent mediator of inflammation and regulator of innate and adaptive immune responses, and autoimmune diseases such as experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis ..
  6. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Malfunctioning B cells are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis...
  7. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Autoimmune diseases like Multiple Sclerosis (MS) result from poorly understood interactions between genetic background of the ..
  8. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..and Musculoskeletal Diseases" Patients with rheumatoid arthritis (RA), other chronic arthritides and other autoimmune diseases inflammatory or not, have partial chronic disrupted sleep...
  9. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..clinical and basic science investigators who have research interests in the etiology and pathogenesis of autoimmune diseases and seek to identify novel therapeutics for more effective patient treatments...
  10. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autoimmune diseases in aggregate represent a leading cause of morbidity and mortality...
  11. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..Of interest, decreased serum levels of 25(OH)VD3 have been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and ..
  12. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autoimmune diseases, a constellation of chronic, disabling illnesses that result from the immune system attacking the body's own tissues, are estimated to adversely affect up to 25 million ..
  13. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..of Excellence (the Center) is the study of the regulation of CD4 T cells in pathogenesis and treatment of autoimmune diseases. The Center will support and be supported by other ACE groups across the United States;and will take ..
  14. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis...
  15. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..it is likely involved in similar immune regulatory pathways, which also operate in RA and perhaps in autoimmune diseases in general...
  16. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..for the activity of several inflammatory cytokines with known importance in LGL leukemia and other autoimmune diseases. In Specific Aim 1, we will confirm our hypothesis that loss of CD62L expression is mediated primarily by ..
  17. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Th17 cells have been implicated in the pathogenesis of multiple different autoimmune diseases including experimental autoimmune encephalitis, collagen-induced arthritis, and inflammatory bowel disease...
  18. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders.
  19. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Most autoimmune diseases affect more females than males...
  20. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
    ..Specifically as PcP mostly affects patients with low CD4 counts such as with HIV, individuals with autoimmune diseases and hematological malignancies as a result of the diseases themselves or the treatments received...
  21. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..of this process is likely to lead to safer and more effective therapies for infectious diseases, autoimmune diseases, and cancer...
  22. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3 blockers we have further validated Kv1.3 as a potential therapeutic target for TEM cell mediated autoimmune diseases by demonstrating that autoreactive T cells from patients with multiple sclerosis, type-1 diabetes and ..
  23. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..it is exquisitely translational, as (at the time when expensive biologics enter clinical trials) it provies a sound mechanistic basis for use of inexpensive and available epigenetic modulators as therapeutics in autoimmune diseases. !
  24. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..research, and small prevention trials strongly suggest that these nutritional agents reduce the risk of autoimmune diseases, reduce levels of circulating pro-inflammatory cytokines, and decrease chronic joint pain...
  25. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..establish myself as an independent investigator in laboratory based research focused on the mechanisms of autoimmune diseases caused by dysregulated signal transduction in immune cells...
  26. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..RELEVANCE: Macrophages participate in many inflammatory processes including responses to infections and autoimmune diseases by secreting cytokines...
  27. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    Researchers have puzzled for decades over why many autoimmune diseases like systemic lupus erythematosus (SLE) disproportionately affect women...
  28. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There are over 80 different autoimmune diseases that are debilitating against which currently there is no cure...
  29. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..in some circumstances, B1a B-cells contribute substantially to the immunopathogenesis of chronic systemic autoimmune diseases such as rheumatoid arthritis (RA), Sjogren's syndrome and systemic lupus erythematosus (SLE)...
  30. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..autoimmunity and inflammation would both suggest novel therapeutic targets for arthritis and other autoimmune diseases and indicate unrecognized effects of therapies currently under development...
  31. The molecular mechanism of Aire: partnering with DNA-PK
    Diane J Mathis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autoimmune diseases afflict 7-10% of Americans, and their incidence is rising...
  32. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..suppress and/or eliminate effector memory (TEM) cells that have been implicated in the pathogenesis of many autoimmune diseases without affecting other immune cells. This proposal focuses on the voltage-gated Kv1...
  33. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..goal of the current proposal is to investigate the contribution of sex chromosomes in the gender bias in autoimmune diseases such as systemic lupus erythematosus, which affect women much more frequently than men with a ratio of 9:1...
  34. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..b>Autoimmune diseases are among the most common diseases in the US...
  35. ROLE OF COREGULATORS IN STEROID HORMONE-REGULATED TRANSCRIPTION
    Michael R Stallcup; Fiscal Year: 2013
    ..hormones control normal development and play important roles in diseases such as cancer, diabetes, and autoimmune diseases. The new basic knowledge obtained in this project will identify new potential targets for therapeutic ..
  36. HYPONATREMIA-INDUCED OSTEOPOROSIS
    Joseph G Verbalis; Fiscal Year: 2010
    ..diseases of the gastrointestinal tract, chronic obstructive pulmonary disease, organ transplantation, autoimmune diseases, genetic diseases, and marrow-based and neoplastic disorders in 18% in aggregate...
  37. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many systemic autoimmune diseases affect both the synovial joints and the cardiovascular system...
  38. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune diseases. No pharmacological treatment is available...
  39. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..STIM and Orai proteins are being developed as targets for treatment of autoimmune diseases and prevention of transplant rejection...
  40. The relative roled of sex and genes during development of systemic autoimmunity
    TRINE NORGAARD JORGENSEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Many systemic autoimmune diseases are more common in females than in males...
  41. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..Considering the critical role of IL-17 in various inflammatory and autoimmune diseases, it is highly significant to investigate the mechanistic role of IL-17 signaling in the disease process, ..
  42. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..In addition, mice lacking RORyt are refractory to the induction of several autoimmune diseases. These findings suggest that RORyt may be an attractive target for pharmacological intervention in multiple ..
  43. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..recipients of allo-HSCT, but also for individuals with T cell deficiencies due to aging (lymphoid atrophy), autoimmune diseases, genetic causes (such as SCID), infectious diseases (HIV, hepatitis B/C), corticosteroids, shock, radio- or ..
  44. Sex Differences in Complement during Myocarditis/DCM
    Delisa Fairweather; Fiscal Year: 2013
    ..applicant): Sex/gender differences exist for most chronic inflammatory diseases such as cardiovascular and autoimmune diseases. Men have a higher incidence and severity of cardiovascular diseases (CVDs) including myocarditis/dilated ..
  45. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..by applicant): SEX DIFFERENCES AND ESTROGEN RECEPTORS REGULATE DENDRITIC CELLS IN INFLAMMATION Abstract Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are strongly female biased, yet the cellular and ..
  46. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..Underlying allergic, asthmatic and autoimmune diseases are activated innate and adaptive host inflammatory pathways that are modulated by genetic and ..
  47. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..recipients of allo-HSCT, but also for individuals with T cell deficiencies due to aging (lymphoid atrophy), autoimmune diseases, infectious diseases, shock, radio- or chemo-therapy and radiation injury (nuclear accident or terrorism).
  48. A Systems Biology Approach for Pediatric and Adult Autoimmune Diseases
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2013
    ..this collaborative setting, a systems biology approach is proposed to focus on both pediatric and adult autoimmune diseases. The goals of the Center are: 1) To assess the efficacy of novel targeted therapies, 2) To develop simple ..
  49. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..lead to the development of new tools for clinicians and clinical researchers to use in the assessment of autoimmune diseases. PUBLIC HEALTH RELEVANCE: Autoimmune diseases are common causes of illness that are difficult to diagnose ..
  50. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..endothelial cells, and identify new therapeutic targets for intervention in neuroinflammation and CNS autoimmune diseases. PUBLIC HEALTH RELEVANCE Neuroinflammation is a common etiology in many CNS disorders, including infection (..
  51. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    ..serious damage to host tissue and destroy anti-microbial defenses in pneumonia and other inflammatory and autoimmune diseases. To examine the mechanisms by which SerpinB1 inhibits NETosis, we will identify and characterize the ..
  52. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..A few studies suggest increased risk of autoimmune diseases among women with endometriosis...
  53. Mechanisms of Peripheral Induction of T-Cell Tolerance
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013
    ..self-Ags) in the secondary lymphoid organs (periphery) are critical for preventing development of autoimmune diseases, but can also limit the induction of desirable responses to self-Ags, as in the case of tumor vaccines, or ..
  54. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..of studies report that individuals suffering from chronic inflammatory diseases including allergic and autoimmune diseases have a higher incidence of psychiatric complications related to increased emotional reactivity and poor ..
  55. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..some severe cases leads to death via emergency venous thrombosis/embolism;and secondary APS compounds other autoimmune diseases such as lupus and venous thromboembolism...
  56. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..Their protective role in a model of viral persistence associated with limited ongoing inflammation may distinguish them from detrimental events prevailing during chronic inflammatory autoimmune diseases.
  57. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..natalizumab, which interferes with neutrophil trafficking have demonstrated marked therapeutic efficacy in autoimmune diseases, but also exhibited potentially fatal immunosuppression...
  58. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2013
    ..by applicant): The central theme of this application is to clarify the role of regulatory T cells (Treg) in autoimmune diseases and explore their potential as therapeutic agents...
  59. Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA Damage
    Narsing A Rao; Fiscal Year: 2010
    ..Once clarified, these results on initial events of TLR activation might have a global implications in autoimmune diseases and specific DNA damage in neuronal cells from TLR4 activation...
  60. Merkel cells specify innervating SAI sensory neuron phenotype.
    Erin G Reed-Geaghan; Fiscal Year: 2013
    ..the treatment of a number of human conditions where there are inherent defects in the somatosensory system (autoimmune diseases, demyelinating diseases, genetic abnormalities, infections, injuries, metabolic disorders, toxic exposures, ..
  61. Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell function
    Ulf Beier; Fiscal Year: 2013
    ..Likewise, therapies for autoimmune diseases and organ transplantation face the challenge of achieving enough immunosuppression to prevent organ ..
  62. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..and chemokines in a rapid burst which has a broad immunological influence, including protection against autoimmune diseases, host responses to parasites and bacteria, and anti-tumor responses...
  63. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..abstract) - The major histocompatibility complex (MHC) is an important susceptibility locus for many human autoimmune diseases. Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is strongly associated with ..
  64. MOLECULAR AND CELLULAR REGULATION OF TOLERANCE
    Yongwon Choi; Fiscal Year: 2010
    ..to limit immunological responses properly, because failure to do so may cause chronic inflammation or autoimmune diseases. Thus, understanding the molecular and cellular pathways that appropriately regulate immune responses will ..
  65. Analysis of Human B Cell Tolerance in Humanized Mice
    Roberta Pelanda; Fiscal Year: 2009
    b>Autoimmune diseases can develop upon defects in the process of tolerance, a process that eliminates and control self-reactive lymphocytes...
  66. Activation of Innate Immunity by Small Ribonucleoprotein
    Westley Reeves; Fiscal Year: 2007
    Many patients with chronic autoimmune diseases such as systemic lupus erythematosus (SLE) develop autoantibodies to ubiquitous host cellular molecules, such as Sm small ribonucleoproteins (snRNPs) containing the small RNAs U1, U2, U4-6, ..
  67. The 5th International Leukocyte Signal Transduction Workshop
    Amnon Altman; Fiscal Year: 2009
    ..A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example...