mucocutaneous lymph node syndrome

Summary

Summary: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.

Top Publications

  1. ncbi Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, Singapore
    Nat Genet 43:1241-6. 2011
  2. ncbi A genome-wide association study identifies three new risk loci for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:517-21. 2012
  3. ncbi Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
    Yi Ching Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Nat Genet 44:522-5. 2012
  4. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Circulation 110:2747-71. 2004
  5. ncbi Kawasaki syndrome
    Jane C Burns
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA
    Lancet 364:533-44. 2004
  6. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Pediatrics 114:1708-33. 2004
  7. ncbi ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease
    Y Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama, Kanagawa, Japan
    Pharmacogenomics J 13:52-9. 2013
  8. ncbi A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease
    Jae Jung Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul, Korea
    Hum Genet 129:487-95. 2011
  9. pmc Association of Kawasaki disease with tropospheric wind patterns
    Xavier Rodo
    Institut Català de Ciències del Clima IC3, Barcelona, Catalonia, Spain Institució Catalana de Recerca i Estudis Avançats ICREA, Barcelona, Catalonia, Spain
    Sci Rep 1:152. 2011
  10. ncbi Polymorphisms of transforming growth factor-β signaling pathway and Kawasaki disease in the Taiwanese population
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pedatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    J Hum Genet 56:840-5. 2011

Research Grants

  1. CHARACTERIZATION AND PATHOBIOLOGY OF PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 1980
  2. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
  3. 8th International Kawasaki Disease Symposium
    Jane Burns; Fiscal Year: 2005
  4. Genetic Markers and gene expression in Kawasaki Disease
    Jane C Burns; Fiscal Year: 2010
  5. Matrix Metalloproteinases in Kawasaki Disease
    Jane Burns; Fiscal Year: 2008
  6. GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    Alessandra Franco; Fiscal Year: 2002
  7. Henoch Schonlein Purpura and Corticosteroid Treatment
    PAMELA WEISS; Fiscal Year: 2008
  8. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
  9. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2008
  10. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2008

Detail Information

Publications260 found, 100 shown here

  1. ncbi Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
    Chiea Chuen Khor
    Infectious Diseases, Genome Institute of Singapore, Singapore
    Nat Genet 43:1241-6. 2011
    ..The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease...
  2. ncbi A genome-wide association study identifies three new risk loci for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:517-21. 2012
    ..6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease...
  3. ncbi Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
    Yi Ching Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Nat Genet 44:522-5. 2012
    ..Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis...
  4. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Circulation 110:2747-71. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  5. ncbi Kawasaki syndrome
    Jane C Burns
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA
    Lancet 364:533-44. 2004
    ..This review includes discussion of the history of the syndrome, the diagnostic challenges, epidemiology, aetiology, pathology, immunopathogenesis, therapy, genetic influences, and the long-term cardiovascular sequelae...
  6. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Pediatrics 114:1708-33. 2004
    ..Coronary artery aneurysms or ectasia develop in approximately 15% to 25% of untreated children and may lead to ischemic heart disease or sudden death...
  7. ncbi ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease
    Y Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama, Kanagawa, Japan
    Pharmacogenomics J 13:52-9. 2013
    ..0031). Our findings strongly suggest the existence of genetic factors affecting patients' responses to treatment and the risk for cardiac complications, and provide clues toward understanding the pathophysiology of KD inflammation...
  8. ncbi A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease
    Jae Jung Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Pungnap 2 dong, Songpa Gu, Seoul, Korea
    Hum Genet 129:487-95. 2011
    ..70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)). These results implicate a locus in the 1p31 region and the PELI1 gene locus in the 2p13.3 region as susceptibility loci for KD and CALs, respectively...
  9. pmc Association of Kawasaki disease with tropospheric wind patterns
    Xavier Rodo
    Institut Català de Ciències del Clima IC3, Barcelona, Catalonia, Spain Institució Catalana de Recerca i Estudis Avançats ICREA, Barcelona, Catalonia, Spain
    Sci Rep 1:152. 2011
    ..Results suggest that the environmental trigger for KD could be wind-borne. Efforts to isolate the causative agent of KD should focus on the microbiology of aerosols...
  10. ncbi Polymorphisms of transforming growth factor-β signaling pathway and Kawasaki disease in the Taiwanese population
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pedatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    J Hum Genet 56:840-5. 2011
    ..This study showed that genetic polymorphisms in TGF-β signaling pathway are associated with KD susceptibility, but not coronary artery lesions formation, or intravenous immunoglobulin treatment response in the Taiwanese population...
  11. pmc ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, Yokohama, Kanagawa, 230 0045, Japan
    Nat Genet 40:35-42. 2008
    ..This finding provides new insights into the mechanisms of immune activation in Kawasaki disease and emphasizes the importance of activated T cells in the pathogenesis of this vasculitis...
  12. pmc Epidemiologic features of Kawasaki disease in Japan: results of the 2009-2010 nationwide survey
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Epidemiol 22:216-21. 2012
    ..Although the number of patients and incidence rate of Kawasaki disease (KD) are increasing in Japan, the most recent epidemiologic features of KD are not known...
  13. pmc Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Epidemiol 20:302-7. 2010
    ..The most recent epidemiologic features of Kawasaki disease (KD) are unknown...
  14. ncbi Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    Acta Paediatr 99:1578-83. 2010
    ..However, many patients with KD still show poor response to initial IVIG treatment. This study was conducted to investigate the risk factors for initial IVIG treatment failure in KD...
  15. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
    ..Post-IVIG treatment eosinophilia has an inverse correlation to KD patients with IVIG-resistance and may indicate IVIG-responsive. This may be a valuable factor to survey for the necessity of a second dose IVIG treatment...
  16. ncbi Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006
    Wen Chan Huang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shan South Road, Taipei 100, Taiwan
    Pediatrics 123:e401-5. 2009
    ..Kawasaki disease is the leading cause of acquired heart disease in children worldwide. This study characterizes the epidemiology of Kawasaki disease in Taiwan between 2003 and 2006...
  17. pmc Genetic polymorphisms in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung, Taiwan, China
    Acta Pharmacol Sin 32:1193-8. 2011
    ..This review will focus on genetic polymorphisms associated with KD and describe some of the possible clinical implications and molecular mechanisms that can be used to explain how genetic variants regulate the pathogenesis in KD...
  18. ncbi Kawasaki disease: an update on diagnosis and treatment
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Pediatr neonatol 53:4-11. 2012
    ....
  19. ncbi Kawasaki disease: infection, immunity and genetics
    Chih Lu Wang
    Division of Pediatric Immunology, Chang Gung Children s Hospital at Kaohsiung, 123 Ta Pei Road, Niau Sung, Kaohsiung 833, Taiwan
    Pediatr Infect Dis J 24:998-1004. 2005
    ....
  20. pmc Epidemiology of Kawasaki disease in Asia, Europe, and the United States
    Ritei Uehara
    Department of Public Health, Jichi Medical University, Shimotsuke, Japan
    J Epidemiol 22:79-85. 2012
    ....
  21. pmc Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease
    Adriana H Tremoulet
    Department of Pediatrics, University of California at San Diego and Rady Children s Hospital, La Jolla, CA, USA
    J Pediatr 161:506-512.e1. 2012
    ..To describe the clinical course and outcome of 10 patients with Kawasaki disease (KD) treated with a calcineurin inhibitor after failing to respond to multiple therapies...
  22. pmc Resistance to intravenous immunoglobulin in children with Kawasaki disease
    Adriana H Tremoulet
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital San Diego, San Diego, CA, USA
    J Pediatr 153:117-21. 2008
    ..To explore the increased incidence of intravenous immunoglobulin- (IVIG) resistance among San Diego County patients with Kawasaki disease (KD) in 2006 and to evaluate a scoring system to predict IVIG-resistant patients with KD...
  23. ncbi Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin
    Caroline Galeotti
    INSERM U 872, Centre de Recherche des Cordeliers, Paris, F 75006, France
    Autoimmun Rev 9:441-8. 2010
    ..They include modification of the cytokine balance, and alteration on both the differentiation and the function of monocytes/macrophages, neutrophils and lymphocytes...
  24. ncbi CD25+CD4+ regulatory T cells in patients with Kawasaki disease
    Kenji Furuno
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Pediatr 145:385-90. 2004
    ....
  25. pmc Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease
    Danica J Schulte
    Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA 90048, USA
    J Immunol 183:5311-8. 2009
    ..These studies are consistent with the interpretation that macrophages and DCs may collaborate with T cells in the pathological mechanisms of coronary arteritis...
  26. ncbi Coronary artery fistula associated with Kawasaki disease
    Chi Di Liang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Am Heart J 157:584-8. 2009
    ..The aim of this study was to investigate the rate, risks factors, and clinical impact of coronary artery fistula (CAF) in Kawasaki disease (KD)...
  27. pmc Transforming growth factor-beta signaling pathway in patients with Kawasaki disease
    Chisato Shimizu
    University of California and Rady Children s Hospital San Diego, San Diego, CA, USA
    Circ Cardiovasc Genet 4:16-25. 2011
    ..We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome...
  28. ncbi Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease: immunohistochemical study
    A Suzuki
    Department of Pediatrics, Tokyo Teishin Hospital, Fujimi, Japan
    Circulation 101:2935-41. 2000
    ..Remodeling of the coronary artery lesions in Kawasaki disease has been observed in longitudinal angiographic studies. However, mechanisms of such remodeling have not yet been elucidated...
  29. ncbi IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease
    A H Rowley
    Ward 12 140, Pediatrics W 140, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    J Infect Dis 182:1183-91. 2000
    ..These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney...
  30. ncbi Kawasaki disease in families
    Y Fujita
    Department of Public Health, Jichi Medical School, Tochigi ken, Japan
    Pediatrics 84:666-9. 1989
    ..For siblings younger than 1 year of age, it was 8.4%, and for those between 1 and 2 years of age, it was 9.3%. More than half (54.1%) of the second cases developed 10 days or less after the first cases occurred...
  31. ncbi Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms: a single-institution experience
    Kenji Suda
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan
    Circulation 123:1836-42. 2011
    ..The aim of this study was to determine the long-term prognosis of patients with Kawasaki disease with giant aneurysms...
  32. ncbi Single-nucleotide polymorphism rs2290692 in the 3'UTR of ITPKC associated with susceptibility to Kawasaki disease in a Han Chinese population
    Qian Peng
    Department of Pediatrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, 610072, Sichuan, China
    Pediatr Cardiol 33:1046-53. 2012
    ..More notably, this finding suggests that there may be an unidentified ITPKC polymorphism in strong linkage disequilibrium to rs2290692, significantly affecting susceptibility to KD in the Han population...
  33. ncbi Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease
    Shu Fen Wu
    Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 19:99-102. 2005
    ..The genotype I/II for IL1-Ra and the frequency of allele II for IL1-Ra are associated with a higher susceptibility to KD, and thus may be useful markers for predicting the development of KD...
  34. ncbi Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm
    Yao Yuan Hsieh
    School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    J Clin Lab Anal 24:262-8. 2010
    ..HLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations...
  35. ncbi Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis
    Kee Soo Ha
    Department of Pediatrics, Korea University Medical Center Guro Hospital, 148 Gurodong ro, Guro Gu, Seoul, 152 703, Republic of Korea
    Eur J Pediatr 172:343-9. 2013
    ..969, 95 % CI = 1.240-3.127, p = 0.004). In conclusion, incomplete KD seems to be associated with an increased risk of CAA, and this is more prominent in patients younger than 12 months, Asians and Indians...
  36. pmc Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study
    Fuu Jen Tsai
    School of Chinese Medicine, China Medical University, Taichung, Taiwan
    PLoS ONE 6:e16853. 2011
    ..These findings may lead to a better understanding of the underlying molecular pathogenesis of KD...
  37. ncbi Searching for the cause of Kawasaki disease--cytoplasmic inclusion bodies provide new insight
    Anne H Rowley
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, The Center for Kawasaki Disease, The Children s Memorial Hospital, Chicago, Illinois 60611, USA
    Nat Rev Microbiol 6:394-401. 2008
    ..Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD...
  38. ncbi CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    J Hum Genet 56:161-5. 2011
    ..009, under the recessive model). The A allele of rs72689236 is very likely to be a risk allele in the development of aneurysm in patients with KD...
  39. ncbi Superantigens in dermatology
    Edgar S Macias
    Department of Dermatology, New York Medical College, New York, New York 10029, USA
    J Am Acad Dermatol 64:455-72; quiz 473-4. 2011
    ..The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment...
  40. ncbi Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial
    Tohru Kobayashi
    Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan
    Lancet 379:1613-20. 2012
    ..We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in patients with severe Kawasaki disease...
  41. ncbi Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 20:266-72. 2009
    ..An increase of eosinophils and IL-5, but not ECP levels after IVIG treatment, was inversely correlated with CAL formation in KD...
  42. ncbi Risk factors for Kawasaki disease-associated coronary abnormalities differ depending on age
    DooIl Song
    Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea
    Eur J Pediatr 168:1315-21. 2009
    ..The clinical manifestations and risk factors for developing coronary artery abnormalities (CAA) in Kawasaki disease (KD) might differ depending on age...
  43. ncbi Kawasaki disease in parents and children
    R Uehara
    Department of Public Health, Jichi Medical School Tochigi, Japan
    Acta Paediatr 92:694-7. 2003
    ..To estimate the probability that the parents of patients with Kawasaki disease also had a history of the same disease...
  44. ncbi Complete and incomplete Kawasaki disease: two sides of the same coin
    Cedric Manlhiot
    Labatt Family Heart Centre, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Eur J Pediatr 171:657-62. 2012
    ..001). No significant difference between groups were seen in regard to coronary artery abnormalities (incomplete 13% versus complete 11%, p = 0.58)...
  45. ncbi A regulatory polymorphism in promoter region of TNFR1 gene is associated with Kawasaki disease in Chinese individuals
    Guo Bing Wang
    Department of Immunology, Shenzhen Institute of Pediatrics, Affiliated Shenzhen Children s Hospital, Chongqing Medical University, Shenzhen, China
    Hum Immunol 72:451-7. 2011
    ..446E-07, odds ratio = 2.26, 95% confidence interval = 1.65-3.11). Therefore, our results suggested that regulatory polymorphism -609T/G and the haplotype TAGAA may be related to increased susceptibility to KD in Chinese individuals...
  46. ncbi Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
    Chiea Chuen Khor
    Division of Infectious Diseases, Genome Institute of Singapore, Singapore
    J Med Genet 48:467-72. 2011
    ....
  47. pmc Kawasaki disease: novel insights into etiology and genetic susceptibility
    Anne H Rowley
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Annu Rev Med 62:69-77. 2011
    ..S. children. Identification of the etiologic agent and of genes conferring KD susceptibility are the best means of improving diagnosis and therapy and enabling prevention of this important disorder of childhood...
  48. pmc Spatial and temporal clustering of Kawasaki syndrome cases
    Annie S Kao
    Division of Epidemiology, Graduate School of Public Health, San Diego State University, San Diego, CA, USA
    Pediatr Infect Dis J 27:981-5. 2008
    ....
  49. ncbi CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    J Clin Immunol 31:240-4. 2011
    ..This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL)...
  50. ncbi Elevated anti-alpha-enolase antibody levels in Kawasaki disease
    J K Chun
    Department of Paediatrics, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea
    Scand J Rheumatol 37:48-52. 2008
    ..The role of alpha-enolase in KD was assessed by measuring anti-alpha-enolase antibody (Ab) titres in patients with KD and the usefulness of anti-alpha-enolase Ab as a diagnostic tool in atypical KD patients was evaluated...
  51. ncbi Prospective study of Kawasaki disease complications: review of 115 cases
    Natália Ribeiro de M Alves
    Unidade de Reumatologia Pediátrica, Hospital de Base de Brasília, Brasilia
    Rev Assoc Med Bras 57:295-300. 2011
    ..To draw attention to complications that might arise in any Kawasaki disease (KD) stage, risk factors contributing to the onset of complications and possible transient or permanent disease sequelae...
  52. pmc IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan
    Kai Sheng Hsieh
    Department of Pediatric Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Dis Markers 30:51-9. 2011
    ..061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and -592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study...
  53. ncbi TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease
    Margalit E Rosenkranz
    Pediatric Rheumatology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Circulation 112:2966-73. 2005
    ....
  54. ncbi Kawasaki disease in Korea, 2003-2005
    Yong Won Park
    Department of Pediatrics, Inje University, Seoul, Republic of Korea
    Pediatr Infect Dis J 26:821-3. 2007
    ..The aim of this study was to investigate the incidence rate and epidemiologic patterns of Kawasaki disease in Korea for the 3-year-period, 2003-2005...
  55. ncbi The riddle of Kawasaki disease
    Jane C Burns
    Division of Pediatric Allergy, Immunology, and Rheumatology at the University of California, San Diego, School of Medicine, La Jolla, USA
    N Engl J Med 356:659-61. 2007
  56. ncbi Lack of association between ORAI1/CRACM1 gene polymorphisms and Kawasaki disease in the Taiwanese children
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    J Clin Immunol 31:650-5. 2011
    ..This study was conducted to investigate if polymorphisms in ORAI1/CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes...
  57. ncbi Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease
    Hidehiko Kariyazono
    Department of Pediatrics, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Pediatr Res 56:953-9. 2004
    ..4422(AC)11 repeats showed a weaker silencer function than the A2 allele with 12 AC repeats. These findings suggested that VEGF and its receptor, KDR, genes contributed to the development of CAL in KD patients...
  58. ncbi Hospitalizations for Kawasaki syndrome among children in the United States, 1997-2007
    Robert C Holman
    Division of Viral and Rickettsial Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 29:483-8. 2010
    ..The present study describes the rate and trends of childhood hospitalizations with Kawasaki syndrome (KS) in the United States...
  59. ncbi Epidemiological features of Kawasaki disease in Korea, 2006-2008
    Yong Won Park
    Department of Pediatrics, Inje University, Korea
    Pediatr Int 53:36-9. 2011
    ..The aim of this study was to estimate the incidence and describe the epidemiological characteristics of Kawasaki disease among children in Korea...
  60. ncbi CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease
    T J Brown
    Department of Pediatrics, Northwestern University Medical School, and Children's Memorial Hospital, Chicago, Illinois 60611, USA
    J Infect Dis 184:940-3. 2001
    ....
  61. ncbi Epidemiologic study on Kawasaki disease in Beijing from 2000 through 2004
    Zhong Dong Du
    Department of Cardiology, Beijing Children s Hospital, Capital University of Medical Sciences, Beijing, China
    Pediatr Infect Dis J 26:449-51. 2007
    ..9 to 55.1 per 100,000 children <5 years of age. The incidence of coronary complications was 20.6% in the acute stage, and 6.9% in the 1-2 month follow-up...
  62. pmc Common variants in CASP3 confer susceptibility to Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama 230 0045, Japan
    Hum Mol Genet 19:2898-906. 2010
    ..Our findings suggest that altered CASP3 expression in immune effecter cells influences susceptibility to KD...
  63. pmc ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics and Clinical Genomic and Proteomic Core laboratory, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    PLoS ONE 6:e17370. 2011
    ..001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population...
  64. ncbi A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease
    Hong Ren Yu
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan
    Pediatr Allergy Immunol 20:699-707. 2009
    ....
  65. ncbi Kawasaki Disease update
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, Rady Children s Hospital, La Jolla, CA 92093, USA
    Indian J Pediatr 76:71-6. 2009
    ..New treatments aimed at modifying the host immune response are currently under study. The genetic influence on susceptibility and disease outcome is an area of active research...
  66. ncbi Kawasaki disease: update on pathogenesis
    Rae S M Yeung
    Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Rheumatol 22:551-60. 2010
    ....
  67. ncbi Prevalence of coronary artery abnormality in incomplete Kawasaki disease
    Tomoyoshi Sonobe
    Department of Pediatrics, Japanese Red Cross Medical Center, Tokyo, Japan
    Pediatr Int 49:421-6. 2007
    ..The aim of the present study was to determine the prevalence of coronary artery abnormality (CAA) and other clinical features in patients with incomplete Kawasaki disease (iKD) using the data from the 17th Japanese nationwide survey of KD...
  68. pmc Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease
    Elizabeth S Yellen
    Children s Hospital Boston, Department of Cardiology, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 125:e234-41. 2010
    ..We explored the performance of these recommendations in a multicenter series of US patients with KD with coronary artery aneurysms (CAAs)...
  69. ncbi Association between a novel human coronavirus and Kawasaki disease
    Frank Esper
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Infect Dis 191:499-502. 2005
    ..0 [95% confidence interval, 3.4-74.4]; P=.0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease...
  70. ncbi Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements
    Brian W McCrindle
    University of Toronto, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Circulation 116:174-9. 2007
    ..Analysis of serial normalized artery measurements may reveal a broader continuous spectrum of involvement and different risk factors...
  71. ncbi Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation
    Ming Tai Lin
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatr Infect Dis J 30:148-52. 2011
    ..a functional single nucleotide polymorphism (SNP) (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene has been linked to the susceptibility to Kawasaki disease (KD). The implication remains unclear...
  72. ncbi Increasing incidence of Kawasaki disease in Japan: nationwide survey
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Pediatr Int 50:287-90. 2008
    ..The last nationwide survey of Kawasaki disease in Japan was conducted in 2003; the epidemiologic features of the disease in Japan since then are unknown...
  73. pmc A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease
    David Burgner
    School of Pediatrics and Child Health, University of Western Australia, Perth, Australia
    PLoS Genet 5:e1000319. 2009
    ..This is one of the first GWAS in an infectious disease. We have identified novel, plausible, and functionally related variants associated with KD susceptibility that may also be relevant to other cardiovascular diseases...
  74. pmc Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease
    T Matsubara
    Department of Paediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Clin Exp Immunol 141:381-7. 2005
    ..This review focuses on the immune response of peripheral blood lymphocytes and monocytes/macrophages during acute KD...
  75. pmc Hospitalisation with infection, asthma and allergy in Kawasaki disease patients and their families: genealogical analysis using linked population data
    Rebecca J Webster
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, Australia
    PLoS ONE 6:e28004. 2011
    ..We investigated whether hospitalisation for infection and asthma/allergy were different in Kawasaki disease-affected children and their relatives...
  76. ncbi Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study
    Mary Beth Son
    Department of Medicine, Children s Hospital Boston, Boston, MA, USA
    J Pediatr 158:644-649.e1. 2011
    ..To test the hypothesis that first re-treatment with infliximab, compared with intravenous immunoglobulin (IVIG), might improve outcomes in IVIG-resistant Kawasaki disease...
  77. ncbi Mortality among persons with a history of Kawasaki disease in Japan: the fifth look
    Yosikazu Nakamura
    Department of Public Health, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    Arch Pediatr Adolesc Med 156:162-5. 2002
    ..To determine whether patients with Kawasaki disease have a higher death rate than an age-matched healthy population after disease occurrence...
  78. ncbi Major histocompatibility complex class I chain-related gene polymorphisms: associated with susceptibility to Kawasaki disease and coronary artery aneurysms
    Yao Yuan Hsieh
    School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan
    Genet Test Mol Biomarkers 15:755-63. 2011
    ..We aimed to investigate whether genetic variations in a major histocompatibility complex (MHC) class could be used as markers of susceptibility in KD and coronary artery aneurysm lesions (CALs)...
  79. ncbi Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease
    Y C Huang
    Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Int J Immunogenet 37:439-43. 2010
    ..2 mg dL(-1) vs. 8.5 mg dL(-1) , P = 0.036). In conclusion, the results of this study suggest that the rs2229634 SNP in the ITPR3 gene is associated with the risk of CAA formation in Taiwanese KD patients...
  80. ncbi BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children
    Kai Chung Hsueh
    Children s Medical Center, China Medical University Hospital, Taichung, Taiwan
    Eur J Pediatr 169:713-9. 2010
    ..In conclusion, our results suggest that BTNL2 gene polymorphisms might be genetic markers of KD susceptibility and risk of coronary artery complication in Taiwanese children...
  81. ncbi The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease
    Hyun Seung Jin
    Department of Pediatrics, College of Medicine, Ulsan University, Asian Medical Center, Seoul 138 736, Korea
    Pediatr Res 61:584-7. 2007
    ..50-8.16] compared with KD children with the common IL-10 (-627A) allele. These findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in KD...
  82. pmc Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease
    K Ikeda
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Exp Immunol 160:246-55. 2010
    ....
  83. pmc Delayed diagnosis by physicians contributes to the development of coronary artery aneurysms in children with Kawasaki syndrome
    Matthew S Wilder
    Department of Pediatrics 0830, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0830, USA
    Pediatr Infect Dis J 26:256-60. 2007
    ..In this study, we examined the contributions of sociodemographic factors and parent and physician behavior to the development of coronary artery aneurysms in children with Kawasaki syndrome...
  84. ncbi Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins
    Willemijn B Breunis
    Emma Children s Hospital, Academic Medical Center, and Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 64:306-15. 2012
    ..This study was undertaken to fine-map these associations and to gain further insight into their role in this vasculitis of unknown etiology to further the search for improved diagnostic and therapeutic options...
  85. ncbi The effect of Kawasaki disease on childhood allergies - a sibling control study
    Woei Kang Liew
    Department of Paediatrics Medicine, KK Women s and Children s Hospital, Singapore
    Pediatr Allergy Immunol 22:488-93. 2011
    ..Kawasaki disease (KD) is a multisystem inflammatory vasculitis of childhood, with widespread T-helper cell type 1 immune activation. We hypothesize that children who suffered from KD will have a lower risk of developing allergic diseases...
  86. pmc Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease
    Nadine F Choueiter
    Division of Cardiology, Department of Pediatrics, University of Washington and Center for Developmental Therapeutics, Seattle Children s Hospital and Research Institute, Seattle, WA, USA
    J Pediatr 157:960-966.e1. 2010
    ..Tumor necrosis factor-α levels are elevated in children with KD, suggesting a role for etanercept in treatment...
  87. pmc Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease
    Harutaka Katano
    Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo, Japan
    Int J Clin Exp Pathol 5:814-23. 2012
    ..genome was detected in both DNA (77 reads) and RNA (2,925 reads) samples. Further studies are required to reveal any association of microbial or viral infection with the pathogenesis of KD...
  88. ncbi Commentary: translation of Dr. Tomisaku Kawasaki's original report of fifty patients in 1967
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, USA
    Pediatr Infect Dis J 21:993-5. 2002
  89. ncbi Matrix metalloproteinase-9 in vascular lesions and endothelial regulation in Kawasaki disease
    Koichi Sakata
    Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Circ J 74:1670-5. 2010
    ..MMP-9 is an essential vasculature-remodeling factor but its role in the vascular lesions of KD is not understood. This study focused on MMP-9 regulation via cytokines in endothelial cells (ECs)...
  90. ncbi Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease
    S F Wu
    Department of Pediatrics, China Medical University Hospital, No 2 Yuh Der Road Taichung, Taiwan, Republic of China
    Pediatr Cardiol 25:529-33. 2004
    ....
  91. ncbi Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan
    Luan Yin Chang
    Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Infect Dis 193:283-6. 2006
    ..All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan...
  92. ncbi Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease
    Fu Yuan Huang
    Department of Pediatrics, Mackay Memorial Hospital, 45, Min Sheng Rd, Tamshui, 25115 Taipei, Taiwan
    J Clin Immunol 28:405-10. 2008
    ....
  93. ncbi ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children
    Hsin Chi
    Department of Pediatrics and Infectious Disease, Mackay Memorial Hospital, 92, Section 2, Chung Shan North Road, Taipei 10449, Taiwan
    Hum Mol Genet 19:1147-51. 2010
    ..In conclusion, we did not find a statistically significant association between the ITPKC gene SNP rs28493229 and KD or CALs in Taiwanese children...
  94. ncbi Kawasaki disease in Israel
    Maskit Bar-Meir
    Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatr Infect Dis J 30:589-92. 2011
    ..To characterize the epidemiology and estimate the incidence of Kawasaki disease (KD) among children in Israel...
  95. ncbi Early treatment with intravenous immunoglobulin in patients with Kawasaki disease
    Shirley M L Tse
    Division of Rheumatology and Cardiology, Department of Pediatrics, Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada
    J Pediatr 140:450-5. 2002
    ....
  96. ncbi Adenoviral infections in children: the impact of rapid diagnosis
    Christian Rocholl
    Department of Pediatrics, Brown University, Providence, Rhode Island
    Pediatrics 113:e51-6. 2004
    ..Direct fluorescent assay (DFA) for the rapid diagnosis of ADV infection, as part of a viral respiratory panel, became available at Primary Children's Medical Center (Salt Lake City, UT) in December 2000...
  97. ncbi Serum levels of neutrophil activation cytokines in Kawasaki disease
    H Suzuki
    Department of Pediatrics, Wakayama Medical University, Wakayama, Japan
    Pediatr Int 43:115-9. 2001
    ....
  98. ncbi Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002
    Luan Yin Chang
    Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
    Pediatrics 114:e678-82. 2004
    ..The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated...
  99. pmc Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California San Diego School of Medicine and Rady Children s Hospital San Diego, La Jolla, CA, USA
    J Pediatr 153:833-8. 2008
    ..To investigate the safety, tolerability, and pharmacokinetics of the anti-tumor necrosis factor-alpha monoclonal antibody infliximab in subjects with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)...
  100. ncbi A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Hum Genet 52:179-90. 2007
    ..This is the first large-scale study of the genetic susceptibility to KD, and our results, combined with the accumulated knowledge of the human genome, could greatly promote research on identification of the molecular pathogenesis of KD...
  101. ncbi Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease
    Patrick J Gavin
    Division of Infectious Disease, Children s Memorial Hospital, Chicago, Ill, USA
    Arterioscler Thromb Vasc Biol 23:576-81. 2003
    ..We hypothesized that MMP-9 expression is increased in acute KD aneurysms when compared with KD nonaneurysmal arteries and arteries from control children...

Research Grants16

  1. CHARACTERIZATION AND PATHOBIOLOGY OF PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 1980
    ..utilized may contribute significantly to development of rheumatic fever, acute glomerulonephritis, mucocutaneous lymph node syndrome as well as lethal shock...
  2. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
    ..These plans will provide me with opportunities for enhanced career development by acquisition of new research skills, and will be fostered by the strong interdisciplinary research environment at Northwestern. ..
  3. 8th International Kawasaki Disease Symposium
    Jane Burns; Fiscal Year: 2005
    ....
  4. Genetic Markers and gene expression in Kawasaki Disease
    Jane C Burns; Fiscal Year: 2010
    ..This project will build on previous work to understand the genetic basis for susceptibility to KD and its complications, which will lead to new insights into therapeutics and disease prevention. ..
  5. Matrix Metalloproteinases in Kawasaki Disease
    Jane Burns; Fiscal Year: 2008
    ..This K24 award will allow the PI to relinquish administrative responsibilities and to share clinical responsibilities with the fellows to allow more time for mentoring activities. ..
  6. GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    Alessandra Franco; Fiscal Year: 2002
    ..Two strategies will be compared: 1) passive immunotherapy by T cell transfer with selected T cell clones; and 2) active vaccination with the glycopeptides and glycolipids to generate a TF-specific T cell response. ..
  7. Henoch Schonlein Purpura and Corticosteroid Treatment
    PAMELA WEISS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
    ..unreadable]..
  9. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2008
    ....
  10. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2008
    ..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
  11. The Role of a Novel Coronavirus In Kawasaki Disease
    Jeffrey Kahn; Fiscal Year: 2007
    ..We have identified a novel human virus, designated the New Haven coronavirus that is associated with KD. The goals of this study is to investigate the role of this novel virus in KD. [unreadable] [unreadable]..
  12. Development of Autoimmunity During Puberty in SLE
    KATHLEEN O NEIL; Fiscal Year: 2007
    ..The data from this study will allow us to estimate sample size and perform power analyses for a larger study utilizing all CARRA centers. [unreadable] [unreadable]..
  13. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2006
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  14. SHOCK TRIAL: LONG-TERM SURVIVAL AND STATISTICAL SUPPORT
    Lynn Sleeper; Fiscal Year: 2004
    ..abstract_text> ..
  15. Immunobiology of Chlamydia
    Raymond Johnson; Fiscal Year: 2004
    ..3) To determine the effect of adoptive transfer of mucosal CD8 and CD4 T lymphocytes on the natural course of MoPn genital tract infections. ..
  16. Cellular Immunity to Chlamydua at the Epithelial Interface
    RAYMOND MORRIS JOHNSON; Fiscal Year: 2010
    ..Defining what protective T cells look like, and how they function, will be critical for designing and assessing future Chlamydia candidate vaccines. ..