Genomes and Genes
Summary: Edema due to obstruction of lymph vessels or disorders of the lymph nodes.
Publications264 found, 100 shown here
- Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trialMaría Torres Lacomba
Physiotherapy Department, School of Physiotherapy, Alcala de Henares University, E 28871 Alcala de Henares, Madrid, Spain
BMJ 340:b5396. 2010..To determine the effectiveness of early physiotherapy in reducing the risk of secondary lymphoedema after surgery for breast cancer...
- Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesisYukihiro Saito
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Circulation 114:1177-84. 2006b>Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Treatment for this disabling condition remains limited and largely ineffective...
- Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veinsMarika J Karkkainen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
Nat Immunol 5:74-80. 2004..Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in ..
- Lymphedema: a comprehensive reviewAnne G Warren
Harvard Medical School, Boston, MA, USA
Ann Plast Surg 59:464-72. 2007b>Lymphedema is a chronic, debilitating condition that has traditionally been seen as refractory or incurable...
- Lymphatic vascular morphogenesis in development, physiology, and diseaseStefan Schulte-Merker
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
J Cell Biol 193:607-18. 2011..development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic ..
- Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)Pia Ostergaard
Medical Genetics Unit, Biomedical Sciences, St George s University of London, London, UK
Nat Genet 43:929-31. 2011..report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia...
- Lymphedema after gynecological cancer treatment : prevalence, correlates, and supportive care needsVanessa Beesley
Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
Cancer 109:2607-14. 2007Few studies have evaluated lymphedema after gynecological cancer treatment. The aim of this research was to establish prevalence, correlates, and supportive care needs of gynecological cancer survivors who develop lymphedema.
- A model for gene therapy of human hereditary lymphedemaM J Karkkainen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, P O B 63 Haartmaninkatu 8, 00014 Helsinki, Finland
Proc Natl Acad Sci U S A 98:12677-82. 2001Primary human lymphedema (Milroy's disease), characterized by a chronic and disfiguring swelling of the extremities, is associated with heterozygous inactivating missense mutations of the gene encoding vascular endothelial growth factor C/..
- Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurementsSarah A McLaughlin
Breast Service, Department of Surgery, Behavioral Science Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Oncol 26:5213-9. 2008..lymph node biopsy was adopted for the staging of the axilla with the assumption that it would reduce the risk of lymphedema in women with breast cancer...
- Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways StudyMarilyn L Kwan
Kaiser Permanente Northern California, Oakland, 94612, USA
Arch Surg 145:1055-63. 2010To determine the incidence of breast cancer-related lymphedema (BCRL) during the early survivorship period as well as demographic, lifestyle, and clinical factors associated with BCRL development.
- Weight lifting in women with breast-cancer-related lymphedemaKathryn H Schmitz
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
N Engl J Med 361:664-73. 2009Weight lifting has generally been proscribed for women with breast-cancer-related lymphedema, preventing them from obtaining the well-established health benefits of weight lifting, including increases in bone density.
- The comparison of two different physiotherapy methods in treatment of lymphedema after breast surgeryKaradibak Didem
School of Physical Therapy and Rehabilitation, Dokuz Eylul University, 35340, Inciralti Izmir, Turkey
Breast Cancer Res Treat 93:49-54. 2005The aim of this study was to compare two different physiotherapy methods in the treatment of lymphedema after breast surgery.
- The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trialMargaret L McNeely
Department of Rehabilitation Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada
Breast Cancer Res Treat 86:95-106. 2004The purpose of this investigation was to compare the reduction in arm lymphedema volume achieved from manual lymph drainage massage (MLD) in combination with multi-layered compression bandaging (CB) to that achieved by CB alone.
- Lymphedema and quality of life in breast cancer survivors: the Iowa Women's Health StudyRehana L Ahmed
Department of Dermatology, University of Minnesota, Minneapolis, MN 55455 0392, USA
J Clin Oncol 26:5689-96. 2008The impact of lymphedema or related arm symptoms on health-related quality of life (HRQOL) in breast cancer (BrCa) survivors has not been examined using a large population-based cohort.
- Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasisTatiana V Petrova
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
Nat Med 10:974-81. 2004..In lymphedema-distichiasis (LD), lymphatic vessel function fails because of mutations affecting the forkhead transcription ..
- Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3T Makinen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, Helsinki, Finland
Nat Med 7:199-205. 2001..have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when ..
- Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedemaJanice N Cormier
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer 116:5138-49. 2010Secondary lymphedema is a debilitating, chronic, progressive condition that commonly occurs after the treatment of breast cancer...
- Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programsPaul T Cantey
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Negl Trop Dis 4:e728. 2010..The objectives of this study were to assess the impact of these refinements and of a lymphedema morbidity management program on MDA compliance.
- Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repairTomer Avraham
Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Am J Pathol 177:3202-14. 2010b>Lymphedema is a complication of cancer treatment occurring in approximately 50% of patients who undergo lymph node resection. Despite its prevalence, the etiology of this disorder remains unknown...
- The risk of developing arm lymphedema among breast cancer survivors: a meta-analysis of treatment factorsREBECCA J TSAI
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
Ann Surg Oncol 16:1959-72. 2009As more women survive breast cancer, long-term complications that affect quality of life, such as lymphedema of the arm, gain greater importance...
- Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptomsSandra A Norman
Department of Medicine, Division of Hematology Oncology, Center for Clinical Epidemiologyand Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Oncol 27:390-7. 2009To examine the incidence, degree, time course, treatment, and symptoms of lymphedema in breast cancer survivors.
- Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedemaKristiana Gordon
Human Genetics Research Centre, Biomedical Sciences, St George s University of London, London, United Kingdom
Circ Res 112:956-60. 2013..receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients with classic Milroy disease, suggesting genetic ..
- Candidate gene analysis in primary lymphedemaRobert E Ferrell
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Lymphat Res Biol 6:69-76. 2008Primary lymphedema, the accumulation of protein-rich fluid in the interstitial space, is the clinical manifestation of mutations involved in lymphatic development and function...
- Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patternsTakumi Yamamoto
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Plast Reconstr Surg 127:1979-86. 2011..has been a highly useful modality in the clinical examination and surgical management of patients with lymphedema. No formal classification system of indocyanine green imaging findings according to the severity of lymphedema ..
- Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health StudyRehana L Ahmed
Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE, Minneapolis, MN 55455 0392, USA
Breast Cancer Res Treat 130:981-91. 2011Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort...
- Lymphedema and breast cancer: a review of the literatureMichael Stamatakos
4th Department of Surgery, Medical School, Attikon General Hospital, University of Athens, Athens, Greece
Breast Cancer 18:174-80. 2011..One of the most important sequelae of the treatment of breast cancer is the development of lymphedema. There are many issues for women to deal with after treatment for breast cancer...
- Risk factors for lymphedema after breast cancer treatmentSandra A Norman
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Cancer Epidemiol Biomarkers Prev 19:2734-46. 2010As cancer treatments evolve, it is important to reevaluate their effect on lymphedema risk in breast cancer survivors.
- Different physical treatment modalities for lymphoedema developing after axillary lymph node dissection for breast cancer: a reviewNele Devoogdt
Department Physiotherapy, University Hospitals Leuven, Belgium
Eur J Obstet Gynecol Reprod Biol 149:3-9. 2010..Furthermore, high-quality studies are warranted. The long-term effect of Intermittent Pneumatic Compression and the effect of elevation on lymphoedema are not yet proven...
- Prognosis of the upper limb following surgery and radiation for breast cancerTeresa S Lee
Discipline of Physiotherapy, University of Sydney, PO Box 170, Lidcombe, NSW, 2141, Australia
Breast Cancer Res Treat 110:19-37. 2008..Shoulder restriction was reported in between <1% and 67% of participants, lymphedema was reported in between 0 and 34% of participants, shoulder/arm pain was reported in between 9 and 68% of ..
- Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathyPia Ostergaard
Medical Genetics Unit, Biomedical Sciences, St George s University of London, UK
Am J Hum Genet 90:356-62. 2012We have identified KIF11 mutations in individuals with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy...
- Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trialSabine Mand
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Clin Infect Dis 55:621-30. 2012The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing infection (positive for circulating filarial antigen [CFA]), or whether the majority of CFA-..
- Upper-body morbidity after breast cancer: incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of careSandra C Hayes
Queensland University of Technology, Institute of Health and Biomedical Innovation, School of Public Health, Brisbane, Australia
Cancer 118:2237-49. 2012..of this paper is to review the incidence of upper-body morbidity (arm and breast symptoms, impairments, and lymphedema), methods for diagnosis, and prevention and treatment strategies...
- Breast cancer related lymphedema in patients with different loco-regional treatmentsBeyza Ozcinar
Istanbul University, Istanbul Medical Faculty, General Surgery Department, Istanbul, Turkey
Breast 21:361-5. 2012b>Lymphedema, a sequela of breast cancer and breast cancer therapy, changes functional abilities and may affect a patient's psychosocial adjustment and overall quality of life...
- Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissectionTakamaru Ashikaga
University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Surg Oncol 102:111-8. 2010....
- Near-infrared fluorescence imaging of lymphatics in head and neck lymphedemaErik A Maus
Division of Cardiology and Hyperbaric Medicine, Department of Internal Medicine at The University of Texas Health Science Center, Houston, Texas, USA
Head Neck 34:448-53. 2012b>Lymphedema is a complication that may occur after surgical resection and radiation treatment in a number of cancer types and is especially debilitating in regions where treatment options are limited...
- Anti-inflammatory pharmacotherapy with ketoprofen ameliorates experimental lymphatic vascular insufficiency in miceKenta Nakamura
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 4:e8380. 2009..in this disease, we examined the impact of a nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, and of a soluble TNF-alpha receptor (sTNF-R1) upon tumor necrosis factor (TNF)-alpha activity in a mouse model of acquired lymphedema.
- The incidence of arm edema in women with breast cancer randomized on the National Surgical Adjuvant Breast and Bowel Project study B-04 to radical mastectomy versus total mastectomy and radiotherapy versus total mastectomy aloneMelvin Deutsch
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, University of Pittsburgh Medical Center, Department of Radiation Oncology, Pittsburgh, PA, USA
Int J Radiat Oncol Biol Phys 70:1020-4. 2008..To determine the incidence and factors associated with the development of arm edema in women who participated in the National Surgical Adjuvant Breast and Bowel Project (NSABP) study B-04...
- A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedemaA F Williams
Marie Curie Centre, Fairmile, Frogston Road West, Edinburgh, UK
Eur J Cancer Care (Engl) 11:254-61. 2002..The study provides evidence to support the use of MLD in women with breast cancer-related lymphoedema. The limitations of the study are outlined and future areas for study are highlighted...
- MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vesselsChristian Lohrmann
Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
Microvasc Res 76:42-5. 2008..To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels...
- Indocyanine green-enhanced lymphography for upper extremity lymphedema: a novel severity staging system using dermal backflow patternsTakumi Yamamoto
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Plast Reconstr Surg 128:941-7. 2011Management of arm lymphedema following breast cancer treatment is challenging, and emphasis should be put on early diagnosis and prevention of secondary lymphedema...
- Fibrosis is a key inhibitor of lymphatic regenerationTomer Avraham
Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Plast Reconstr Surg 124:438-50. 2009b>Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven...
- The standard of care for lymphedema: current concepts and physiological considerationsHarvey N Mayrovitz
College of Medical Sciences, Nova Southeastern University, Ft Lauderdale, FL 33328, USA
Lymphat Res Biol 7:101-8. 2009The standard of care for lymphedema encompasses risk reduction, early detection, Phase-I Complete Decongestive Therapy in a clinical setting, and Phase-II Self Management at home...
- Breast cancer-related arm lymphedema: incidence rates, diagnostic techniques, optimal management and risk reduction strategiesChirag Shah
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
Int J Radiat Oncol Biol Phys 81:907-14. 2011As more women survive breast cancer, long-term toxicities affecting their quality of life, such as lymphedema (LE) of the arm, gain importance...
- Management of secondary lymphedema related to breast cancerOren Cheifetz
Hamilton Health Sciences, 711 Concession St, Hamilton, ON L8V 1C3
Can Fam Physician 56:1277-84. 2010AbstractOBJECTIVE To review recent literature on the management of secondary lymphedema following breast cancer.QUALITY OF EVIDENCE MEDLINE, EMBASE, AMED, PubMed,and the Internet were searched for articles published between 2005 and 2009...
- Integrating modern dermatology and Ayurveda in the treatment of vitiligo and lymphedema in IndiaSaravu R Narahari
Department of Integrative Dermatology, Institute of Applied Dermatology, Kasaragod, India
Int J Dermatol 50:310-34. 2011....
- The relation between arm/shoulder problems and quality of life in breast cancer survivors: a cross-sectional and longitudinal studyInger Lise Nesvold
National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital and University of Oslo, Oslo, Norway
J Cancer Surviv 5:62-72. 2011..and longitudinal study of breast cancer survivors (BCSs) examines the associations between arm/shoulder problems (ASPs), which consist of pain, restricted mobility and lymphedema, and different aspects of quality of life (QoL).
- Pathophysiological aspects of lymphedema of human limbs: I. Lymph protein compositionWaldemar L Olszewski
Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
Lymphat Res Biol 1:235-43. 2003..In this article, we report our observations on changes in the protein composition of lymph in obstructive lymphedema. We have documented that the protein concentrations in lymph tissue fluid of the extremities remain within ..
- Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculatureJan Kazenwadel
Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, 5000 SA, Australia
Blood 119:1283-91. 2012..MDS/AML or "MonoMAC" syndrome patients with GATA2 deletions and one with a frameshift mutation also have primary lymphedema. Primary lymphedema occurs as a result of aberrations in the development and/or function of lymphatic vessels, ..
- Effect of treatment with low-intensity and extremely low-frequency electrostatic fields (Deep Oscillation) on breast tissue and pain in patients with secondary breast lymphoedemaSilke Jahr
Department of Physical Medicine and Rehabilitation, Charité Universitetsmedizin Berlin, Germany
J Rehabil Med 40:645-50. 2008....
- Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokinesJamie C Zampell
the Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Am J Physiol Cell Physiol 302:C392-404. 2012..that nude mice have significantly improved lymphatic function compared with wild-type mice in a tail model of lymphedema. We show that gradients of lymphatic fluid stasis regulate the expression of lymphangiogenic cytokines (VEGF-A, ..
- Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndromeSusan L Dagenais
Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
Gene Expr Patterns 4:611-9. 2004..Hence, the genes responsible for hereditary lymphedema are of great interest due to the potential for providing insights into the mechanisms of lymphatic development, ..
- Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosisJ A Petrek
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer 92:1368-77. 2001BACKGROUND: To the authors' knowledge, there are no long-term cohort studies of lymphedema, despite the substantial morbidity of arm swelling...
- Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up studyYa Chen Tina Shih
Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas M D Anderson Cancer Center, PO Box 301402, Houston, TX 77230 1402, USA
J Clin Oncol 27:2007-14. 2009This study estimated the economic burden of breast cancer-related lymphedema (BCRL) among working-age women, the incidence of lymphedema, and associated risk factors.
- Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservationMargaret Thompson
Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Ann Surg Oncol 14:1890-5. 2007..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema.
- The validation of a quality of life scale to assess the impact of arm morbidity in breast cancer patients post-operativelyS Coster
Department of Oncology, University of Sussex, Brighton, UK
Breast Cancer Res Treat 68:273-82. 2001..Given the dearth of existing scales available to measure arm morbidity, we hope this new tool will prove useful to researchers...
- Molecular mechanisms of lymphangiogenesis in health and diseaseKari Alitalo
Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
Cancer Cell 1:219-27. 2002..Nonetheless, insufficient lymphangiogenesis causes incapacitating lymphedema, while lymphatic growth around tumors may facilitate metastatic spread of malignant cells that ultimately kill ..
- Self-reported arm-lymphedema and functional impairment after breast cancer treatment--a nationwide study of prevalence and associated factorsRune Gärtner
Department of Breast Surgery, Rigshospitalet 3103, Copenhagen University, 2100 Copenhagen, Denmark
Breast 19:506-15. 2010b>Lymphedema and impairment of function are well-established sequelae to breast cancer treatment and affect an increasing number of women due to continually improved survival...
- Filariasis and lymphoedemaK M Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Parasite Immunol 31:664-72. 2009....
- Lymphedema following axillary lymph node dissection for breast cancerGeorge H Sakorafas
4th Department of Surgery, Attikon University Hospital, Athens University, Medical School, Arkadias 19 21, GR 115 26 Athens, Greece
Surg Oncol 15:153-65. 2006b>Lymphedema is a relatively common, potentially serious and unpleased complication after axillary lymph node dissection (ALND) for breast cancer...
- Inflammatory manifestations of experimental lymphatic insufficiencyRaymond Tabibiazar
Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Med 3:e254. 2006Sustained lymph stagnation engenders a pathological response that is complex and not well characterized. Tissue inflammation in lymphedema may reflect either an active or passive consequence of impaired immune traffic.
- Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasiaAlexandre Irrthum
Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Brussels, Belgium
Am J Hum Genet 72:1470-8. 2003Hereditary lymphedema is a developmental disorder characterized by chronic swelling of the extremities due to dysfunction of the lymphatic vessels...
- Lymphedema and quality of life in survivors of early-stage breast cancerSarah M Beaulac
Department of Epidemiology, Boston University Medical Center, Mass, USA
Arch Surg 137:1253-7. 2002..Despite increased use of breast-conserving surgery, lymphedema rates are similar to those with more radical surgery.
- Lymphedema after breast cancer: incidence, risk factors, and effect on upper body functionSandra C Hayes
Institute of Health and Biomedical Innovation, School of Public Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia
J Clin Oncol 26:3536-42. 2008Secondary lymphedema is associated with adverse physical and psychosocial consequences among women with breast cancer (BC)...
- Mutations in CCBE1 cause generalized lymph vessel dysplasia in humansMarielle Alders
Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands
Nat Genet 41:1272-4. 2009b>Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome...
- Lymphedema and bladder-emptying difficulties after radical hysterectomy for early cervical cancer and among population controlsK Bergmark
Gynecological Oncology, Department of Oncology Pathology, Radiumhemmet, Karolinska Institutet, Stockholm, Sweden
Int J Gynecol Cancer 16:1130-9. 2006..treated with radical hysterectomy, as compared with controls, had an 8-fold increase in symptoms indicating lymphedema (25% reported distress due to lymphedema), a nearly 9-fold increase in difficult emptying of the bladder, and a ..
- Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC TrialRobert E Mansel
Department of Surgery, Cardiff University, Cardiff, UK
J Natl Cancer Inst 98:599-609. 2006....
- Concurrent validity of upper-extremity volume estimates: comparison of calculated volume derived from girth measurements and water displacement volumeJoy R Karges
Department of Physical Therapy, Division of Health Sciences, School of Medicine, University of South Dakota, 414 E Clark St, Vermillion 57069, USA
Phys Ther 83:134-45. 2003..The purpose of this study was to determine the concurrent validity of calculated volume and water displacement volume measurements...
- Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volumeAntoinette P Sander
Department of Physical Therapy and Human Movement Sciences, The Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Suite 1100, Chicago, IL 60611, USA
Phys Ther 82:1201-12. 2002Upper-extremity (UE) swelling following breast cancer treatment is a frequent manifestation of lymphedema. In order to document outcomes from lymphedema treatments, reliable, valid, and practical measurements of UE swelling are necessary...
- Reliability and validity of arm volume measurements for assessment of lymphedemaRichard Taylor
School of Population Health, Faculty of Health Sciences, University of Queensland, Herston, Queensland, Australia
Phys Ther 86:205-14. 2006Arm lymphedema following breast cancer surgery is a continuing problem. In this study, we assessed the reliability and validity of circumferential measurements and water displacement for measuring upper-limb volume.
- T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedemaVivien Schacht
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
EMBO J 22:3546-56. 2003..These defects are associated with diminished lymphatic transport, congenital lymphedema and dilation of lymphatic vessels...
- Clinical practice guidelines for the care and treatment of breast cancer: 11. LymphedemaS R Harris
School of Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC
CMAJ 164:191-9. 2001..information and recommendations for women and their physicians when making decisions about the management of lymphedema related to breast cancer...
- Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissectionClaude Nos
Department of Gynecologic and Oncologic Surgery, Hopital Europeen Georges Pompidou, Paris, France
Ann Surg Oncol 14:2490-6. 2007..many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema. With the new awareness of lymphatic spread in the axillary nodes, it should be possible to define a new ..
- Older breast cancer survivors: factors associated with self-reported symptoms of persistent lymphedema over 7 years of follow-upKerri M Clough-Gorr
Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
Breast J 16:147-55. 2010b>Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time...
- Changes in arm morbidities and health-related quality of life after breast cancer surgery - a five-year follow-up studyAse Sagen
Department of Breast and Endocrine Surgery, Ullevaal University Hospital, Oslo, Norway
Acta Oncol 48:1111-8. 2009..The subjects were examined for arm volumes and arm lymphedema, arm pain, sensation of heaviness, shoulder function, physical activity level, and HRQoL, prior to surgery, and ..
- Axillary reverse mapping for breast cancerMasakuni Noguchi
Department of Breast and Endocrine Surgery, Kanazawa Medical University Hospital, Uchinada daigaku 1 1, Ishikawa 920 0293, Japan
Breast Cancer Res Treat 119:529-35. 2010..during axillary lymph node dissection (ALND) and/or sentinel lymph node (SLN) biopsy, thereby minimizing arm lymphedema. However, several problems remain to be resolved in the practical application of this technique...
- Changes in the Body Image and Relationship Scale following a one-year strength training trial for breast cancer survivors with or at risk for lymphedemaRebecca M Speck
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Blockley Hall, Philadelphia, PA 19104 6021, USA
Breast Cancer Res Treat 121:421-30. 2010..strength training intervention on perceptions of body image in 234 breast cancer survivors (112 with lymphedema) who participated in the Physical Activity and Lymphedema (PAL) trial...
- Reliability and limits of agreement of circumferential, water displacement, and optoelectronic volumetry in the measurement of upper limb lymphedemaT Deltombe
Department of Physical Medicine, Universite Catholique de Louvain, Cliniques Universitaires de Mont Godinne, Yvoir, Belgium
Lymphology 40:26-34. 2007..by water displacement volumetry, and by infrared optoelectronic volumetry in the assessment of upper limb lymphedema. Thirty women with lymphedema following axillary lymph node dissection surgery for breast cancer surgery were ..
- Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective studyDavid W Chang
Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Plast Reconstr Surg 126:752-8. 2010b>Lymphedema is a common and debilitating condition. Management options for lymphedema are limited and controversial...
- HGF and MET mutations in primary and secondary lymphedemaDavid N Finegold
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Lymphat Res Biol 6:65-8. 2008b>Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance...
- Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White womenKathleen A Meeske
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Breast Cancer Res Treat 113:383-91. 2009Purpose Lymphedema of the arm is a potential complication of breast cancer therapy...
- A chronic and latent lymphatic insufficiency follows recovery from acute lymphedema in the rat forelegUziel Mendez
Biomedical Engineering Department, Michigan Technological University, Houghton, Michigan 49931, USA
Am J Physiol Heart Circ Physiol 303:H1107-13. 2012Secondary lymphedema in humans is a common consequence of axillary lymph node dissection (ALND) to treat breast cancer...
- Indocyanine green (ICG) lymphography is superior to lymphoscintigraphy for diagnostic imaging of early lymphedema of the upper limbsMakoto Mihara
Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan
PLoS ONE 7:e38182. 2012Secondary lymphedema causes swelling in limbs due to lymph retention following lymph node dissection in cancer therapy...
- Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compressionAndrzej Szuba
Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Cancer 95:2260-7. 2002..axillary lymph node dissection, with or without radiation therapy, reportedly is the most common cause of lymphedema in developed countries. There is no cure for breast carcinoma-associated lymphedema...
- MR lymphography of lymphatic vessels in lower extremity with gynecologic oncology-related lymphedemaQing Lu
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
PLoS ONE 7:e50319. 2012To characterize lymphatic vessel morphology in lower extremity lymphedema using MR lymphography at 3T.
- Complications of lymphadenectomy for gynecologic cancerA Achouri
Service de Chirurgie Cancérologique Gynécologique et du Sein, Hopital Europeen Georges Pompidou, AP HP, Paris, France
Eur J Surg Oncol 39:81-6. 2013Symptomatic postoperative lymphocysts (SPOLs) and lower-limb lymphedema (LLL) are probably underestimated complications of lymphadenectomy for gynecologic malignancies...
- Can a practicing surgeon detect early lymphedema reliably?Keiva L Bland
Department of Surgery, School of Medicine, Wayne State University, Detroit, MI, USA
Am J Surg 186:509-13. 2003b>Lymphedema may be identified by simpler circumference changes as compared with changes in limb volume.
- Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized studyL Andersen
Department of Oncology, Aarhus University Hospital, Denmark
Acta Oncol 39:399-405. 2000..of manual lymphatic drainage (MLD) to the standard therapy could improve treatment outcome in women with lymphedema of the ipsilateral arm after breast cancer treatment...
- A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011Bonnie B Lasinski
Lymphedema Therapy and The Boris Lasinski School, Woodbury, NY
PM R 4:580-601. 2012To critically analyze the contemporary published research that pertains to the individual components of complete decongestive therapy (CDT), as well as CDT as a bundled intervention in the treatment of lymphedema.
- An audit of the incidence of arm lymphoedema after prophylactic level I/II axillary dissection without division of the pectoralis minor muscleG Querci della Rovere
Breast Unit, Royal Marsden NHS Trust, Sutton, Surrey, UK
Ann R Coll Surg Engl 85:158-61. 2003..When lymphoedema in any site was considered, right-sided treatment and nodal status were independently significant...
- Breast cancer-related lymphedema: comparing direct costs of a prospective surveillance model and a traditional model of careNicole L Stout
National Naval Medical Center, Breast Care Center, Bethesda, MD 20814, USA
Phys Ther 92:152-63. 2012..Breast cancer treatment sequelae, such as lymphedema, may occur early or late and often negatively affect function...
- The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedemaAbuzer Dirican
Department of Surgery, Division of Surgical Oncology, Magee Womens Hospital University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Support Care Cancer 19:685-90. 2011Breast-cancer-related lymphedema (BCRL) is a chronic disease, and currently there is no definitive treatment for it. There are some therapeutic interventions targeted to decrease the limb swelling and the associated problems...
- Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatmentDavid N Finegold
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Clin Cancer Res 18:2382-90. 2012Secondary lymphedema is a frequent complication of breast cancer associated with surgery, chemotherapy, or radiation following breast cancer treatment...
- Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedemaJoseph M Rutkowski
Institute of Bioengineering, School of Life Sciences LMBM Station 15, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
Am J Pathol 176:1122-9. 2010Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue...
- Efficacy of home-based lymphoedema management in reducing acute attacks in subjects with lymphatic filariasis in Burkina FasoPatrick Jullien
Handicap International, 14 avenue Berthelot, 69007 Lyon, France
Acta Trop 120:S55-61. 2011..5 months). The lymphoedema management requires no additional human resources, but whether its effect can be sustained remains to be seen...
- Impact of community-based lymphedema management on perceived disability among patients with lymphatic filariasis in Orissa State, IndiaPhilip J Budge
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
PLoS Negl Trop Dis 7:e2100. 2013..As many as 40 million have symptoms of LF disease, including lymphedema, elephantiasis, and hydrocele. India constitutes approximately 45% of the world's burden of LF...
- Animal models for the study of lymphatic insufficiencyWilliam S Shin
Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
Lymphat Res Biol 1:159-69. 2003b>Lymphedema is the term commonly employed to describe the spectrum of pathological states that arise as a consequence of functional lymphatic insufficiency. These human disease entities currently lack an effective cure...
- The experience of lower limb lymphedema for women after treatment for gynecologic cancerMary Ryan
Gynaecological Cancer Centre of the Royal Hospital for Women, Randwick, New South Wales, Australia
Oncol Nurs Forum 30:417-23. 2003To describe women's experiences with lower limb lymphedema to inform both preventive and management clinical practices.
- MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedemaChristian Lohrmann
Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
Microvasc Res 77:335-9. 2009To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
- A contemporary, population-based study of lymphedema risk factors in older women with breast cancerTina W F Yen
Division of General Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Ann Surg Oncol 16:979-88. 2009We studied potential risk factors for lymphedema in a contemporary population of older breast cancer patients.
- A phase I study to assess the feasibility and oncologic safety of axillary reverse mapping in breast cancer patientsIsabelle Bedrosian
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston Texas, USA
Cancer 116:2543-8. 2010..mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection...
- Evaluation of the clinical effectiveness of physiotherapeutic management of lymphoedema in palliative care patientsKatri Elina Clemens
Department of Science and Research, Centre for Palliative Medicine, University of Bonn, Bonn, Germany
Jpn J Clin Oncol 40:1068-72. 2010..The aim of the study was to evaluate the frequency and effect of manual lymphatic drainage in palliative care patients with lymphoedema in a far advanced stage of their disease...
- Cholesterol and Lymphatic Transport of Molecules and CellsMelody A Swartz; Fiscal Year: 2012..The importance of this concept became clearer to us when we observed that mice with primary lymphedema, devoid of dermal lymphatic capillaries, unexpectedly had elevated levels of circulating plasma cholesterol...
- Human in Mouse Modeling of HNSCC to Predict Resonse to TherapyWendell G Yarbrough; Fiscal Year: 2010..and swallowing defects, shoulder dysfunction, accelerated arteriosclerosis of the carotid, xerostomia, trismus, lymphedema and neck muscle fibrosis...
- The Role of Connexin32 in the Pathogensis of CMTXSTEVEN SIMON SCHERER; Fiscal Year: 2013..1. Investigate the molecular defects of hCx47 mutants causing PMLD or familial lymphedema. In the last grant cycle of this grant, we showed that 3 recessive Cx47 mutants associated with PMLD have ..
- Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer SurvivorsSheila H Ridner; Fiscal Year: 2013..exist as PT is: 1) short-term and does not address MSI changes over time secondary to progressing fibrosis and lymphedema as noted in our current study, 2) conducted at facility-based centers with less emphasis and monitoring of home ..
- Proinflammatory Biomarkers and Post-Breast CancerLymphedemaMei Rosemary Fu; Fiscal Year: 2012..5 million breast cancer survivors in the U.S. more than 40% of them have developed lymphedema (LE)...
- Cellular Mechanisms of Lymphatic Muscle ContractilityMICHAEL JOHN DAVIS; Fiscal Year: 2012Over ten million people in the US currently suffer from some form of lymphedema, including a high percentage of patients recovering from mastectomy or reconstructive surgery...
- Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema MonitoringWilliam F Weitzel; Fiscal Year: 2013..of disease states, including chronic kidney disease (CKD), congestive heart failure (CHF), liver failure, and lymphedema. Currently, serial physical examinations by a skilled clinician provide the input for clinical decision making...
- The role of lymphatic contraction in inflammation and cancer metastasisShan Liao; Fiscal Year: 2013..Following the treatment with radiation and surgery, cancer patients frequently develop lymphedema. While in the US about 3 million patients develop lymphedema as a result of cancer therapy, the major cause of ..
- Psychosexual Intervention for Gynecologic Cancer PatientsBarbara L Andersen; Fiscal Year: 2012..patients, one of the most disruptive and long-lasting sources of morbidity is sexual, second only to extremity lymphedema. Over 50% of patients have moderate-to-severe sexual disruption, as documented with 30+ years of descriptive ..
- Lymphotoxin: Regulation and Biologic FunctionNANCY RUDDLE; Fiscal Year: 2009..of the factors that can induce lymphangiogenesis and thus provide therapeutic insight into the pathology of lymphedema. The data will suggest modalities for treatment of lymphatic vessel insufficiency by controlled local ..
- Characterization of lymphatic contraction during infectionTimothy P Padera; Fiscal Year: 2013..Chronic infections, such as in cellulitis, are frequently associated with lymphedema, which is generally associated with malfunctions or disruptions in the function of collecting lymphatic vessels...
- Disseminating PALKathryn H Schmitz; Fiscal Year: 2012..S. today. As a common and morbid effect of BrCa treatment, lymphedema ranks principal among concerns of long-term survivors...
- Short-Term Institutional Research Training GrantMarlys Hearst Witte; Fiscal Year: 2013..g. heart failure, developmental abnormalities, cardiac arrest/resuscitation, transplantation, artificial hearts, lymphedema-angiodysplasia syndromes);cancer (e.g...
- The Fibrosis-Lymphedema Continuum in Head and Neck CancerSheila H Ridner; Fiscal Year: 2013..Fibrosis and lymphedema secondary to the stromal response to [tissue damage from tumor or treatment are understudied and poorly ..
- Role of CCBE1 in lymphangiogenesisDAVID RICHARD ENIS; Fiscal Year: 2013..to be mutated in patients with a severe inherited form of swelling in their skin and intestines known as "Lymphedema-lymphangiectasia-mental retardation syndrome" or Hennekam Syndrome...
- Role of a9b1 Integrin in lymphangiogenesisNicholas E Vlahakis; Fiscal Year: 2010..largely been ignored, however recently it has become clear this has been a mistake since human diseases such as lymphedema are clearly associated with genetic abnormalities of the VEGF control system for the lymphatic vessels...
- Early Detection and Treatment of Lymphedema in Women with Breast CancerAlphonse G Taghian; Fiscal Year: 2013b>Lymphedema, a swelling of the upper extremity due to an accumulation of protein rich interstitial fluid, significantly impacts the quality of life of patients who develop this complication following their treatment for breast cancer...
- Endogenous Specific Inhibitor of Corneal LymphangiogenesisJayakrishna Ambati; Fiscal Year: 2013..The impact of these studies also extends to pathological states such as tumor metastasis, lymphedema, and lymphangioma, which can be better studied and possibly treated by modulating the endogenous uncoupler of ..
- Molecular regulation of lymphangiogenesis in corneal alloimmunityLu Chen; Fiscal Year: 2013..diseases alone since lymphatic dysfunction is associated with a diverse array of diseases and conditions, which include but are not limited to cancer metastasis, inflammation, infections, diabetes, obesity, hypertension and lymphedema.
- Quantifying the role of load-induced remodeling in lymphedema progressionJAMES BRANDON DIXON; Fiscal Year: 2013DESCRIPTION (provided by applicant): Recent estimates suggest that the prevalence of lymphedema in developed countries is as high as 1.44 per thousand persons...
- 2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and DiseaseGUILLERMO C OLIVER; Fiscal Year: 2012..surveillance and lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in ..
- Therapeutic Lymphatic Collecting Vessel Regeneration by Directed Fluid FlowJeremy Goldman; Fiscal Year: 2012DESCRIPTION (provided by applicant): Secondary lymphedema is often acquired as a consequence of axillary dissection, performed in an effort to treat breast cancer...
- Role of Neuropilin receptors in lymphangiogenesisANNE CHRISTINE EICHMANN; Fiscal Year: 2013..impaired lymphatic vessel development causes fluid and protein accumulation in the interstitium, resulting in lymphedema and a persistent inflammatory response...
- Imaging lymph function in humans and in a murine model of lymphedemaEva M Sevick-Muraca; Fiscal Year: 2012..the diagnosis and management of lymph diseases in a population of patients who suffer from primary and secondary lymphedema. In this research application, we hypothesize that: near infrared (NIR) optical methods can be used to image ..
- Molecular Targeting of Lymphatic Endothelial Receptors for Ligand-directed ImaginRENATA contact PASQUALINI; Fiscal Year: 2010..vasculature plays a critical role in the pathogenesis of many diseases including inflammatory disorders, lymphedema, tumor progression, and metastasis...
- Southern Community Cancer Survivorship StudyAnn Marie Flores; Fiscal Year: 2010..limitations and symptoms (shoulder range of motion &strength, ability to accomplish functional tasks, lymphedema, pain, fatigue) than non-minorities. H1...
- Mechanisms of fibrosis and lymphatic dysfunction in post-surgical lymphedemaBABAK MEHRARA MEHRARA; Fiscal Year: 2013DESCRIPTION (provided by applicant): Lymphedema is the accumulation of protein rich fluid in tissues, and in the US, occurs most commonly as a surgical complication of cancer treatment...
- RASA1-mediated control of lymphatic vessel growth and functionPhilip D King; Fiscal Year: 2012..by which the growth and function of lymphatic vessels can be manipulated to clinical benefit in diseases such as lymphedema and cancer...
- Therapy for Secondary Lymphedema in Breast CancerAnnissa Furr; Fiscal Year: 2013..radical mastectomy and sentinel lymph node removal during the treatment of breast cancer is the development of lymphedema in related limbs...
- Biomarkers for the Detection of Lymphatic Vascular InsufficiencyStanley G Rockson; Fiscal Year: 2010..Acquired lymphatic vascular dysfunction (lymphedema) is a common, chronic, debilitating disease that is frequently under-recognized or misdiagnosed, and many ..
- The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Richard R Barakat; Fiscal Year: 2013DESCRIPTION (provided by applicant): The proposed study, "Lymphedema and Gynecologic cancer (LEG): Incidence, Risk Factors and Impact", will innovatively utilize the cooperative group setting of the GOG (Gynecologic Oncology Group) to ..
- Genetic investigation of Notch signaling in lymphatic endotheliumMark L Kahn; Fiscal Year: 2010Defects in lymphatic vessel growth cause human lymphedema while tumor-induced lymphangiogenesis provides a route for tumor metastasis...
- Lymphatic RadiobiologyTimothy P Padera; Fiscal Year: 2013Axillary radiation with surgery in breast cancer patients often leads to lymphedema, which affects nearly 400,000 women in the United States. Lymphedema is disfiguring, painful and forms a nidus for infection...
- Long-term Arm Morbidity Following Breast Cancer TreatmentChristine A Miaskowski; Fiscal Year: 2010..The specific aims of the proposed study are to: determine the prevalence, severity, and the timing of the lymphedema (LE);determine the prevalence and timing of occurrence of changes in shoulder mobility and changes in grip ..
- Bioelectrical Impedance for Self-Monitoring of Breast Cancer Related LymphedemaSheila H Ridner; Fiscal Year: 2012DESCRIPTION (provided by applicant): Breast cancer treatment-related lymphedema (swelling) is an incurable, chronic condition experienced by a significant percentage of breast cancer survivors...
- Penn TREC Survivor CenterKathryn H Schmitz; Fiscal Year: 2013..Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2...
- HGF and MET Mutations in Primary LymphademaROBERT EDWARD contact FERRELL; Fiscal Year: 2010Primary lymphedema is the cl inical expression of defects in lymphatic development and function. Three genes have been shown to cause primary lymphedema, VEGFR3, FOXC2 and SOX18...
- Prox1 in Mammalian LymphangiogenesisGUILLERMO C OLIVER; Fiscal Year: 2013..Malfunctions of the lymphatic system can lead to congenital or inherited disorders such as lymphedema, a disfiguring and disabling disorder that is caused by imbalance in lymph absorption and often characterized by ..
- FOXC2 in Hereditary Lymphedema and Lymphatic DevelopmentThomas Glover; Fiscal Year: 2007..As with many other developmental pathways, genes involved in hereditary lymphedema can provide important insights into the molecular events involved in lymphangiogenesis...
- Bone Morphogenic Protein Signaling in Lymphatic Endothelial CellsSuk Won Jin; Fiscal Year: 2013..significant both in increasing our basic understanding of how lymphatic development is coordinated and provide a theoretical background in developing therapeutic interventions for lymphedema and other dysfunctions of lymphatic vessels.
- Lymphangiogenesis and Angiogenesis in Airway InflammationDonald McDonald; Fiscal Year: 2009..leads to abnormalities in mucosal lymphatics that impair fluid drainage, and could lead to bronchial lymphedema, which worsens airway obstruction and perturbs immune responses by altering the normal balance of fluid/cell ..
- 2010 Molecular Mechanisms in Lymphatic Function and Disease Gordon Research ConfeMichael J Detmar; Fiscal Year: 2010..This has lead to new insights into diseases such as cancer, cardiovascular diseases, chronic inflammation and lymphedema (both congenital and surgery-induced)...
- Cyber Informatics Tools for Lymphedema StakeholdersChi Ren Shyu; Fiscal Year: 2012..provided by applicant): Researchers and clinicians seek to improve outcomes for patients with and at risk for lymphedema (LE), a chronic, progressive disease of the lymphatic system, often starting with seemingly innocuous ..
- SYNDECAN FUNCTION IN ENDOTHELIAL CELLSMichael Simons; Fiscal Year: 2013DESCRIPTION (provided by applicant): Abnormal lymphangiogenesis leading to lymphedema is a common disorder afflicting tens of millions of individuals throughout the world...
- MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMAMarlys Witte; Fiscal Year: 2002DESCRIPTION (Applicant's Abstract): Massage therapy (in the form of Manual Lymph Drainage (MLD) or Manual Lymphedema Treatment (MLT) is an integral component of the international consensus-recommended optimal treatment for lymphedema(LE) ..
- INTRAOPERATIVE OCT FOR DETERMINING LYMPH NODE STATUS AND STAGING CANCERStephen A Boppart; Fiscal Year: 2013..the surgical removal of lymph nodes, to reduce costs, and most importantly, to reduce or eliminate the risks of lymphedema, a highly morbid and lifelong complication from the surgical treatment of many types of cancer...
- Lymphatic Fluid Flow Modeling with Active Network ComponentsJames E Moore; Fiscal Year: 2012..This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease for which there is no known cure, affects a large number of cancer patients who have ..
- NYU Center for the Study of Asian American HealthChau Trinh-Shevrin; Fiscal Year: 2013..The second research project tests the efficacy of a pilot intervention to reduce the risk of lymphedema among Chinese breast cancer survivors and improve quality of life and health issues for these women...
- Pycnogenol for Treatment of Arm LymphedemaPaul Hutson; Fiscal Year: 2004b>Lymphedema of the arm affects the function and self-image of approximately 600,000 of the 2 million breast cancer survivors in the United States...
- BRUGIAN FILARIASIS IN THE FERRETCATHERINE CRANDALL; Fiscal Year: 1990..of two manifestations of infection: tropical filarial eosinophilia (occult filariasis) and chronic lymphedema. The ferret (Mustela putorius furo) infected with Brugia malayi will be used as an experimental model...
- Shear Stress & Cellular Control of Capillary FunctionDonna Williams; Fiscal Year: 2005..Chronic venous insufficiency, congestive heart failure, and lymphedema represent three human diseases where the capillary barrier is not functioning properly and mechanical ..
- MOLECULAR CHARACTERIZATION OF FAMILIAL LYMPHEDEMAMansoor Sarfarazi; Fiscal Year: 2003DESCRIPTION (Adapted from investigator's abstract): Primary lymphedema is a condition in which there is a deficiency of lymphatic drainage, leading to swelling, frequent recurrent cellulites, and disfigurement of the affected limb or ..
- Control of lymphatic endothelial differentiation programKari Alitalo; Fiscal Year: 2006..Absent or damage lymphatic vessels lead to lymphedema, a chronic and disfiguring swelling of the extremities...
- Massage Therapy for Breast Cancer-related LymphedemaMichael Bernas; Fiscal Year: 2003..of Combined Physical Therapy (CPT), the international consensus-recommended optimal treatment for peripheral lymphedema (LE)...
- Lymphatic RadiobiologyTIMOTHY PADERA; Fiscal Year: 2009Axillary radiation with surgery in breast cancer patients often leads to lymphedema, which affects nearly 400,000 women in the United States. Lymphedema is disfiguring, painful and forms a nidus for infection...
- NURSING MEASUREMENT OF LYMPHEDEMATOUS LIMBSJane Armer; Fiscal Year: 2000DESCRIPTION: Breast cancer treatment is the leading cause of lymphedema in the United States. Two million women with breast cancer are at risk to develop lymphedema during their lifetimes...
- CONQUERING LYMPHATIC DISEASE--SETTING THE RESEARCH AGENDMarlys Witte; Fiscal Year: 2000..Three conferences are planned: 1) Year 1- Lymphatic Vascular Biology and Lymphedema-Angiodysplasia Syndromes will engage scientists from around the world in exploring and characterizing the state-..
- Arm lymphedema in female breast cancer cases diagnosed in IowaRebecca Tsai; Fiscal Year: 2009..of breast cancer have improved survival, consequentially increasing a potentially serious complication called lymphedema. Lymphedema, characterized by painful swelling of the arm, affects 3- 60% of breast cancer survivors, leading to ..
- Integrated optical imaging rat of mesenteryVladimir Zharov; Fiscal Year: 2004..states and under different interventions, such as drug or radiation therapy; modeling of experimental lymphedema; optimization of laser treatment of vascular lesions, and so on. The Specific Aims are to: Specific Aim 1...
- Ultrasound Load-Indentor for Tissue CharacterizationMARY GEYER; Fiscal Year: 2001..and beta-testing for sensitivity and specificity of the device in human subjects with venous disease and lymphedema. It is our intent to manufacture, market and distribute the device or to license the rights to a third party...
- The Impact of Lymphedema on Overall and Local FunctioningMarylin Dodd; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Arm lymphedema may arise at any time after breast cancer surgery and/or radiation therapy...
- : Real-time monitoring of lymphedema using self-reporting, sensors and mobile tePHD DASGUPTA; Fiscal Year: 2013The primary purpose is to develop a real-time method of monitoring lymphedema patients[unreadable] symptoms to be used with a smartphone or tablet when the patients are away from their clinic...
- The Lymphatic Continuum ConferenceStanley Rockson; Fiscal Year: 2002..the publication of a Program Announcement (PA-01-035) soliciting research into the Pathogenesis and Treatment of Lymphedema. It is, therefore, a specific goal of this conference to foster awareness of this program announcement, through ..
- Molecular Mechanisms in Lymphatic Function & DiseaseStanley Rockson; Fiscal Year: 2004..The physiology and human genetics of the lymphatic system will be explored and there will be a focus upon mechanisms of cancer metastasis and its relationship to lymphatic function and lymphangiogenesis. ..