lymphedema

Summary

Summary: Edema due to obstruction of lymph vessels or disorders of the lymph nodes.

Top Publications

  1. pmc Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial
    María Torres Lacomba
    Physiotherapy Department, School of Physiotherapy, Alcala de Henares University, E 28871 Alcala de Henares, Madrid, Spain
    BMJ 340:b5396. 2010
  2. ncbi Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis
    Yukihiro Saito
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 114:1177-84. 2006
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  4. ncbi Lymphedema: a comprehensive review
    Anne G Warren
    Harvard Medical School, Boston, MA, USA
    Ann Plast Surg 59:464-72. 2007
  5. pmc Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
  6. ncbi Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)
    Pia Ostergaard
    Medical Genetics Unit, Biomedical Sciences, St George s University of London, London, UK
    Nat Genet 43:929-31. 2011
  7. ncbi Lymphedema after gynecological cancer treatment : prevalence, correlates, and supportive care needs
    Vanessa Beesley
    Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
    Cancer 109:2607-14. 2007
  8. pmc A model for gene therapy of human hereditary lymphedema
    M J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, P O B 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 98:12677-82. 2001
  9. pmc Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements
    Sarah A McLaughlin
    Breast Service, Department of Surgery, Behavioral Science Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:5213-9. 2008
  10. pmc Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study
    Marilyn L Kwan
    Kaiser Permanente Northern California, Oakland, 94612, USA
    Arch Surg 145:1055-63. 2010

Detail Information

Publications264 found, 100 shown here

  1. pmc Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: randomised, single blinded, clinical trial
    María Torres Lacomba
    Physiotherapy Department, School of Physiotherapy, Alcala de Henares University, E 28871 Alcala de Henares, Madrid, Spain
    BMJ 340:b5396. 2010
    ..To determine the effectiveness of early physiotherapy in reducing the risk of secondary lymphoedema after surgery for breast cancer...
  2. ncbi Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis
    Yukihiro Saito
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 114:1177-84. 2006
    b>Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Treatment for this disabling condition remains limited and largely ineffective...
  3. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in ..
  4. ncbi Lymphedema: a comprehensive review
    Anne G Warren
    Harvard Medical School, Boston, MA, USA
    Ann Plast Surg 59:464-72. 2007
    b>Lymphedema is a chronic, debilitating condition that has traditionally been seen as refractory or incurable...
  5. pmc Lymphatic vascular morphogenesis in development, physiology, and disease
    Stefan Schulte-Merker
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands
    J Cell Biol 193:607-18. 2011
    ..development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic ..
  6. ncbi Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)
    Pia Ostergaard
    Medical Genetics Unit, Biomedical Sciences, St George s University of London, London, UK
    Nat Genet 43:929-31. 2011
    ..report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia...
  7. ncbi Lymphedema after gynecological cancer treatment : prevalence, correlates, and supportive care needs
    Vanessa Beesley
    Queensland University of Technology, School of Public Health, Institute of Health and Biomedical Innovation, Brisbane, Australia
    Cancer 109:2607-14. 2007
    Few studies have evaluated lymphedema after gynecological cancer treatment. The aim of this research was to establish prevalence, correlates, and supportive care needs of gynecological cancer survivors who develop lymphedema.
  8. pmc A model for gene therapy of human hereditary lymphedema
    M J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, P O B 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 98:12677-82. 2001
    Primary human lymphedema (Milroy's disease), characterized by a chronic and disfiguring swelling of the extremities, is associated with heterozygous inactivating missense mutations of the gene encoding vascular endothelial growth factor C/..
  9. pmc Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements
    Sarah A McLaughlin
    Breast Service, Department of Surgery, Behavioral Science Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:5213-9. 2008
    ..lymph node biopsy was adopted for the staging of the axilla with the assumption that it would reduce the risk of lymphedema in women with breast cancer...
  10. pmc Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study
    Marilyn L Kwan
    Kaiser Permanente Northern California, Oakland, 94612, USA
    Arch Surg 145:1055-63. 2010
    To determine the incidence of breast cancer-related lymphedema (BCRL) during the early survivorship period as well as demographic, lifestyle, and clinical factors associated with BCRL development.
  11. ncbi Weight lifting in women with breast-cancer-related lymphedema
    Kathryn H Schmitz
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    N Engl J Med 361:664-73. 2009
    Weight lifting has generally been proscribed for women with breast-cancer-related lymphedema, preventing them from obtaining the well-established health benefits of weight lifting, including increases in bone density.
  12. ncbi The comparison of two different physiotherapy methods in treatment of lymphedema after breast surgery
    Karadibak Didem
    School of Physical Therapy and Rehabilitation, Dokuz Eylul University, 35340, Inciralti Izmir, Turkey
    Breast Cancer Res Treat 93:49-54. 2005
    The aim of this study was to compare two different physiotherapy methods in the treatment of lymphedema after breast surgery.
  13. ncbi The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trial
    Margaret L McNeely
    Department of Rehabilitation Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada
    Breast Cancer Res Treat 86:95-106. 2004
    The purpose of this investigation was to compare the reduction in arm lymphedema volume achieved from manual lymph drainage massage (MLD) in combination with multi-layered compression bandaging (CB) to that achieved by CB alone.
  14. pmc Lymphedema and quality of life in breast cancer survivors: the Iowa Women's Health Study
    Rehana L Ahmed
    Department of Dermatology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    J Clin Oncol 26:5689-96. 2008
    The impact of lymphedema or related arm symptoms on health-related quality of life (HRQOL) in breast cancer (BrCa) survivors has not been examined using a large population-based cohort.
  15. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..In lymphedema-distichiasis (LD), lymphatic vessel function fails because of mutations affecting the forkhead transcription ..
  16. ncbi Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
    T Makinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, Helsinki, Finland
    Nat Med 7:199-205. 2001
    ..have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when ..
  17. ncbi Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema
    Janice N Cormier
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:5138-49. 2010
    Secondary lymphedema is a debilitating, chronic, progressive condition that commonly occurs after the treatment of breast cancer...
  18. pmc Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs
    Paul T Cantey
    Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 4:e728. 2010
    ..The objectives of this study were to assess the impact of these refinements and of a lymphedema morbidity management program on MDA compliance.
  19. pmc Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Pathol 177:3202-14. 2010
    b>Lymphedema is a complication of cancer treatment occurring in approximately 50% of patients who undergo lymph node resection. Despite its prevalence, the etiology of this disorder remains unknown...
  20. ncbi The risk of developing arm lymphedema among breast cancer survivors: a meta-analysis of treatment factors
    REBECCA J TSAI
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
    Ann Surg Oncol 16:1959-72. 2009
    As more women survive breast cancer, long-term complications that affect quality of life, such as lymphedema of the arm, gain greater importance...
  21. pmc Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptoms
    Sandra A Norman
    Department of Medicine, Division of Hematology Oncology, Center for Clinical Epidemiologyand Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 27:390-7. 2009
    To examine the incidence, degree, time course, treatment, and symptoms of lymphedema in breast cancer survivors.
  22. ncbi Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema
    Kristiana Gordon
    Human Genetics Research Centre, Biomedical Sciences, St George s University of London, London, United Kingdom
    Circ Res 112:956-60. 2013
    ..receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients with classic Milroy disease, suggesting genetic ..
  23. ncbi Candidate gene analysis in primary lymphedema
    Robert E Ferrell
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Lymphat Res Biol 6:69-76. 2008
    Primary lymphedema, the accumulation of protein-rich fluid in the interstitial space, is the clinical manifestation of mutations involved in lymphatic development and function...
  24. ncbi Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns
    Takumi Yamamoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Plast Reconstr Surg 127:1979-86. 2011
    ..has been a highly useful modality in the clinical examination and surgical management of patients with lymphedema. No formal classification system of indocyanine green imaging findings according to the severity of lymphedema ..
  25. pmc Risk factors for lymphedema in breast cancer survivors, the Iowa Women's Health Study
    Rehana L Ahmed
    Department of Dermatology, University of Minnesota, Mayo Mail Code 98, 420 Delaware Street SE, Minneapolis, MN 55455 0392, USA
    Breast Cancer Res Treat 130:981-91. 2011
    Risk factors for lymphedema and related arm symptoms in breast cancer (BC) survivors have not been examined using a large prospective population-based cohort...
  26. ncbi Lymphedema and breast cancer: a review of the literature
    Michael Stamatakos
    4th Department of Surgery, Medical School, Attikon General Hospital, University of Athens, Athens, Greece
    Breast Cancer 18:174-80. 2011
    ..One of the most important sequelae of the treatment of breast cancer is the development of lymphedema. There are many issues for women to deal with after treatment for breast cancer...
  27. pmc Risk factors for lymphedema after breast cancer treatment
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 19:2734-46. 2010
    As cancer treatments evolve, it is important to reevaluate their effect on lymphedema risk in breast cancer survivors.
  28. ncbi Different physical treatment modalities for lymphoedema developing after axillary lymph node dissection for breast cancer: a review
    Nele Devoogdt
    Department Physiotherapy, University Hospitals Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 149:3-9. 2010
    ..Furthermore, high-quality studies are warranted. The long-term effect of Intermittent Pneumatic Compression and the effect of elevation on lymphoedema are not yet proven...
  29. ncbi Prognosis of the upper limb following surgery and radiation for breast cancer
    Teresa S Lee
    Discipline of Physiotherapy, University of Sydney, PO Box 170, Lidcombe, NSW, 2141, Australia
    Breast Cancer Res Treat 110:19-37. 2008
    ..Shoulder restriction was reported in between <1% and 67% of participants, lymphedema was reported in between 0 and 34% of participants, shoulder/arm pain was reported in between 9 and 68% of ..
  30. pmc Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy
    Pia Ostergaard
    Medical Genetics Unit, Biomedical Sciences, St George s University of London, UK
    Am J Hum Genet 90:356-62. 2012
    We have identified KIF11 mutations in individuals with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy...
  31. pmc Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial
    Sabine Mand
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Clin Infect Dis 55:621-30. 2012
    The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing infection (positive for circulating filarial antigen [CFA]), or whether the majority of CFA-..
  32. ncbi Upper-body morbidity after breast cancer: incidence and evidence for evaluation, prevention, and management within a prospective surveillance model of care
    Sandra C Hayes
    Queensland University of Technology, Institute of Health and Biomedical Innovation, School of Public Health, Brisbane, Australia
    Cancer 118:2237-49. 2012
    ..of this paper is to review the incidence of upper-body morbidity (arm and breast symptoms, impairments, and lymphedema), methods for diagnosis, and prevention and treatment strategies...
  33. ncbi Breast cancer related lymphedema in patients with different loco-regional treatments
    Beyza Ozcinar
    Istanbul University, Istanbul Medical Faculty, General Surgery Department, Istanbul, Turkey
    Breast 21:361-5. 2012
    b>Lymphedema, a sequela of breast cancer and breast cancer therapy, changes functional abilities and may affect a patient's psychosocial adjustment and overall quality of life...
  34. pmc Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection
    Takamaru Ashikaga
    University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Surg Oncol 102:111-8. 2010
    ....
  35. pmc Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema
    Erik A Maus
    Division of Cardiology and Hyperbaric Medicine, Department of Internal Medicine at The University of Texas Health Science Center, Houston, Texas, USA
    Head Neck 34:448-53. 2012
    b>Lymphedema is a complication that may occur after surgical resection and radiation treatment in a number of cancer types and is especially debilitating in regions where treatment options are limited...
  36. pmc Anti-inflammatory pharmacotherapy with ketoprofen ameliorates experimental lymphatic vascular insufficiency in mice
    Kenta Nakamura
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA
    PLoS ONE 4:e8380. 2009
    ..in this disease, we examined the impact of a nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, and of a soluble TNF-alpha receptor (sTNF-R1) upon tumor necrosis factor (TNF)-alpha activity in a mouse model of acquired lymphedema.
  37. ncbi The incidence of arm edema in women with breast cancer randomized on the National Surgical Adjuvant Breast and Bowel Project study B-04 to radical mastectomy versus total mastectomy and radiotherapy versus total mastectomy alone
    Melvin Deutsch
    National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, University of Pittsburgh Medical Center, Department of Radiation Oncology, Pittsburgh, PA, USA
    Int J Radiat Oncol Biol Phys 70:1020-4. 2008
    ..To determine the incidence and factors associated with the development of arm edema in women who participated in the National Surgical Adjuvant Breast and Bowel Project (NSABP) study B-04...
  38. ncbi A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema
    A F Williams
    Marie Curie Centre, Fairmile, Frogston Road West, Edinburgh, UK
    Eur J Cancer Care (Engl) 11:254-61. 2002
    ..The study provides evidence to support the use of MLD in women with breast cancer-related lymphoedema. The limitations of the study are outlined and future areas for study are highlighted...
  39. ncbi MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg, Germany
    Microvasc Res 76:42-5. 2008
    ..To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels...
  40. ncbi Indocyanine green-enhanced lymphography for upper extremity lymphedema: a novel severity staging system using dermal backflow patterns
    Takumi Yamamoto
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Plast Reconstr Surg 128:941-7. 2011
    Management of arm lymphedema following breast cancer treatment is challenging, and emphasis should be put on early diagnosis and prevention of secondary lymphedema...
  41. ncbi Fibrosis is a key inhibitor of lymphatic regeneration
    Tomer Avraham
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Plast Reconstr Surg 124:438-50. 2009
    b>Lymphedema is a common debilitating sequela of lymph node dissection. Although numerous clinical studies suggest that factors that lead to fibrosis are associated with the development of lymphedema, this relationship has not been proven...
  42. ncbi The standard of care for lymphedema: current concepts and physiological considerations
    Harvey N Mayrovitz
    College of Medical Sciences, Nova Southeastern University, Ft Lauderdale, FL 33328, USA
    Lymphat Res Biol 7:101-8. 2009
    The standard of care for lymphedema encompasses risk reduction, early detection, Phase-I Complete Decongestive Therapy in a clinical setting, and Phase-II Self Management at home...
  43. ncbi Breast cancer-related arm lymphedema: incidence rates, diagnostic techniques, optimal management and risk reduction strategies
    Chirag Shah
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 81:907-14. 2011
    As more women survive breast cancer, long-term toxicities affecting their quality of life, such as lymphedema (LE) of the arm, gain importance...
  44. pmc Management of secondary lymphedema related to breast cancer
    Oren Cheifetz
    Hamilton Health Sciences, 711 Concession St, Hamilton, ON L8V 1C3
    Can Fam Physician 56:1277-84. 2010
    AbstractOBJECTIVE To review recent literature on the management of secondary lymphedema following breast cancer.QUALITY OF EVIDENCE MEDLINE, EMBASE, AMED, PubMed,and the Internet were searched for articles published between 2005 and 2009...
  45. ncbi Integrating modern dermatology and Ayurveda in the treatment of vitiligo and lymphedema in India
    Saravu R Narahari
    Department of Integrative Dermatology, Institute of Applied Dermatology, Kasaragod, India
    Int J Dermatol 50:310-34. 2011
    ....
  46. pmc The relation between arm/shoulder problems and quality of life in breast cancer survivors: a cross-sectional and longitudinal study
    Inger Lise Nesvold
    National Resource Center for Late Effects, Department of Oncology, Oslo University Hospital and University of Oslo, Oslo, Norway
    J Cancer Surviv 5:62-72. 2011
    ..and longitudinal study of breast cancer survivors (BCSs) examines the associations between arm/shoulder problems (ASPs), which consist of pain, restricted mobility and lymphedema, and different aspects of quality of life (QoL).
  47. ncbi Pathophysiological aspects of lymphedema of human limbs: I. Lymph protein composition
    Waldemar L Olszewski
    Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Lymphat Res Biol 1:235-43. 2003
    ..In this article, we report our observations on changes in the protein composition of lymph in obstructive lymphedema. We have documented that the protein concentrations in lymph tissue fluid of the extremities remain within ..
  48. pmc Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature
    Jan Kazenwadel
    Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, 5000 SA, Australia
    Blood 119:1283-91. 2012
    ..MDS/AML or "MonoMAC" syndrome patients with GATA2 deletions and one with a frameshift mutation also have primary lymphedema. Primary lymphedema occurs as a result of aberrations in the development and/or function of lymphatic vessels, ..
  49. ncbi Effect of treatment with low-intensity and extremely low-frequency electrostatic fields (Deep Oscillation) on breast tissue and pain in patients with secondary breast lymphoedema
    Silke Jahr
    Department of Physical Medicine and Rehabilitation, Charité Universitetsmedizin Berlin, Germany
    J Rehabil Med 40:645-50. 2008
    ....
  50. pmc Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines
    Jamie C Zampell
    the Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Am J Physiol Cell Physiol 302:C392-404. 2012
    ..that nude mice have significantly improved lymphatic function compared with wild-type mice in a tail model of lymphedema. We show that gradients of lymphatic fluid stasis regulate the expression of lymphangiogenic cytokines (VEGF-A, ..
  51. ncbi Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    Susan L Dagenais
    Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Gene Expr Patterns 4:611-9. 2004
    ..Hence, the genes responsible for hereditary lymphedema are of great interest due to the potential for providing insights into the mechanisms of lymphatic development, ..
  52. ncbi Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis
    J A Petrek
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer 92:1368-77. 2001
    BACKGROUND: To the authors' knowledge, there are no long-term cohort studies of lymphedema, despite the substantial morbidity of arm swelling...
  53. ncbi Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study
    Ya Chen Tina Shih
    Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas M D Anderson Cancer Center, PO Box 301402, Houston, TX 77230 1402, USA
    J Clin Oncol 27:2007-14. 2009
    This study estimated the economic burden of breast cancer-related lymphedema (BCRL) among working-age women, the incidence of lymphedema, and associated risk factors.
  54. ncbi Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation
    Margaret Thompson
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Surg Oncol 14:1890-5. 2007
    ..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema.
  55. ncbi The validation of a quality of life scale to assess the impact of arm morbidity in breast cancer patients post-operatively
    S Coster
    Department of Oncology, University of Sussex, Brighton, UK
    Breast Cancer Res Treat 68:273-82. 2001
    ..Given the dearth of existing scales available to measure arm morbidity, we hope this new tool will prove useful to researchers...
  56. ncbi Molecular mechanisms of lymphangiogenesis in health and disease
    Kari Alitalo
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Cancer Cell 1:219-27. 2002
    ..Nonetheless, insufficient lymphangiogenesis causes incapacitating lymphedema, while lymphatic growth around tumors may facilitate metastatic spread of malignant cells that ultimately kill ..
  57. ncbi Self-reported arm-lymphedema and functional impairment after breast cancer treatment--a nationwide study of prevalence and associated factors
    Rune Gärtner
    Department of Breast Surgery, Rigshospitalet 3103, Copenhagen University, 2100 Copenhagen, Denmark
    Breast 19:506-15. 2010
    b>Lymphedema and impairment of function are well-established sequelae to breast cancer treatment and affect an increasing number of women due to continually improved survival...
  58. pmc Filariasis and lymphoedema
    K M Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Parasite Immunol 31:664-72. 2009
    ....
  59. ncbi Lymphedema following axillary lymph node dissection for breast cancer
    George H Sakorafas
    4th Department of Surgery, Attikon University Hospital, Athens University, Medical School, Arkadias 19 21, GR 115 26 Athens, Greece
    Surg Oncol 15:153-65. 2006
    b>Lymphedema is a relatively common, potentially serious and unpleased complication after axillary lymph node dissection (ALND) for breast cancer...
  60. pmc Inflammatory manifestations of experimental lymphatic insufficiency
    Raymond Tabibiazar
    Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Med 3:e254. 2006
    Sustained lymph stagnation engenders a pathological response that is complex and not well characterized. Tissue inflammation in lymphedema may reflect either an active or passive consequence of impaired immune traffic.
  61. pmc Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia
    Alexandre Irrthum
    Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Brussels, Belgium
    Am J Hum Genet 72:1470-8. 2003
    Hereditary lymphedema is a developmental disorder characterized by chronic swelling of the extremities due to dysfunction of the lymphatic vessels...
  62. ncbi Lymphedema and quality of life in survivors of early-stage breast cancer
    Sarah M Beaulac
    Department of Epidemiology, Boston University Medical Center, Mass, USA
    Arch Surg 137:1253-7. 2002
    ..Despite increased use of breast-conserving surgery, lymphedema rates are similar to those with more radical surgery.
  63. ncbi Lymphedema after breast cancer: incidence, risk factors, and effect on upper body function
    Sandra C Hayes
    Institute of Health and Biomedical Innovation, School of Public Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Clin Oncol 26:3536-42. 2008
    Secondary lymphedema is associated with adverse physical and psychosocial consequences among women with breast cancer (BC)...
  64. ncbi Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans
    Marielle Alders
    Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Genet 41:1272-4. 2009
    b>Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome...
  65. ncbi Lymphedema and bladder-emptying difficulties after radical hysterectomy for early cervical cancer and among population controls
    K Bergmark
    Gynecological Oncology, Department of Oncology Pathology, Radiumhemmet, Karolinska Institutet, Stockholm, Sweden
    Int J Gynecol Cancer 16:1130-9. 2006
    ..treated with radical hysterectomy, as compared with controls, had an 8-fold increase in symptoms indicating lymphedema (25% reported distress due to lymphedema), a nearly 9-fold increase in difficult emptying of the bladder, and a ..
  66. ncbi Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006
    ....
  67. ncbi Concurrent validity of upper-extremity volume estimates: comparison of calculated volume derived from girth measurements and water displacement volume
    Joy R Karges
    Department of Physical Therapy, Division of Health Sciences, School of Medicine, University of South Dakota, 414 E Clark St, Vermillion 57069, USA
    Phys Ther 83:134-45. 2003
    ..The purpose of this study was to determine the concurrent validity of calculated volume and water displacement volume measurements...
  68. ncbi Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volume
    Antoinette P Sander
    Department of Physical Therapy and Human Movement Sciences, The Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Suite 1100, Chicago, IL 60611, USA
    Phys Ther 82:1201-12. 2002
    Upper-extremity (UE) swelling following breast cancer treatment is a frequent manifestation of lymphedema. In order to document outcomes from lymphedema treatments, reliable, valid, and practical measurements of UE swelling are necessary...
  69. ncbi Reliability and validity of arm volume measurements for assessment of lymphedema
    Richard Taylor
    School of Population Health, Faculty of Health Sciences, University of Queensland, Herston, Queensland, Australia
    Phys Ther 86:205-14. 2006
    Arm lymphedema following breast cancer surgery is a continuing problem. In this study, we assessed the reliability and validity of circumferential measurements and water displacement for measuring upper-limb volume.
  70. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    ..These defects are associated with diminished lymphatic transport, congenital lymphedema and dilation of lymphatic vessels...
  71. pmc Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema
    S R Harris
    School of Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC
    CMAJ 164:191-9. 2001
    ..information and recommendations for women and their physicians when making decisions about the management of lymphedema related to breast cancer...
  72. ncbi Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection
    Claude Nos
    Department of Gynecologic and Oncologic Surgery, Hopital Europeen Georges Pompidou, Paris, France
    Ann Surg Oncol 14:2490-6. 2007
    ..many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema. With the new awareness of lymphatic spread in the axillary nodes, it should be possible to define a new ..
  73. pmc Older breast cancer survivors: factors associated with self-reported symptoms of persistent lymphedema over 7 years of follow-up
    Kerri M Clough-Gorr
    Geriatrics Section, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    Breast J 16:147-55. 2010
    b>Lymphedema of the arm is a common complication of breast cancer with symptoms that can persist over long periods of time...
  74. ncbi Changes in arm morbidities and health-related quality of life after breast cancer surgery - a five-year follow-up study
    Ase Sagen
    Department of Breast and Endocrine Surgery, Ullevaal University Hospital, Oslo, Norway
    Acta Oncol 48:1111-8. 2009
    ..The subjects were examined for arm volumes and arm lymphedema, arm pain, sensation of heaviness, shoulder function, physical activity level, and HRQoL, prior to surgery, and ..
  75. ncbi Axillary reverse mapping for breast cancer
    Masakuni Noguchi
    Department of Breast and Endocrine Surgery, Kanazawa Medical University Hospital, Uchinada daigaku 1 1, Ishikawa 920 0293, Japan
    Breast Cancer Res Treat 119:529-35. 2010
    ..during axillary lymph node dissection (ALND) and/or sentinel lymph node (SLN) biopsy, thereby minimizing arm lymphedema. However, several problems remain to be resolved in the practical application of this technique...
  76. ncbi Changes in the Body Image and Relationship Scale following a one-year strength training trial for breast cancer survivors with or at risk for lymphedema
    Rebecca M Speck
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Blockley Hall, Philadelphia, PA 19104 6021, USA
    Breast Cancer Res Treat 121:421-30. 2010
    ..strength training intervention on perceptions of body image in 234 breast cancer survivors (112 with lymphedema) who participated in the Physical Activity and Lymphedema (PAL) trial...
  77. ncbi Reliability and limits of agreement of circumferential, water displacement, and optoelectronic volumetry in the measurement of upper limb lymphedema
    T Deltombe
    Department of Physical Medicine, Universite Catholique de Louvain, Cliniques Universitaires de Mont Godinne, Yvoir, Belgium
    Lymphology 40:26-34. 2007
    ..by water displacement volumetry, and by infrared optoelectronic volumetry in the assessment of upper limb lymphedema. Thirty women with lymphedema following axillary lymph node dissection surgery for breast cancer surgery were ..
  78. ncbi Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study
    David W Chang
    Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Plast Reconstr Surg 126:752-8. 2010
    b>Lymphedema is a common and debilitating condition. Management options for lymphedema are limited and controversial...
  79. ncbi HGF and MET mutations in primary and secondary lymphedema
    David N Finegold
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Lymphat Res Biol 6:65-8. 2008
    b>Lymphedema is the abnormal accumulation of protein-rich fluid in the interstitial space. Primary lymphedema is a rare genetic condition with both autosomal dominant and autosomal recessive modes of inheritance...
  80. ncbi Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White women
    Kathleen A Meeske
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res Treat 113:383-91. 2009
    Purpose Lymphedema of the arm is a potential complication of breast cancer therapy...
  81. pmc A chronic and latent lymphatic insufficiency follows recovery from acute lymphedema in the rat foreleg
    Uziel Mendez
    Biomedical Engineering Department, Michigan Technological University, Houghton, Michigan 49931, USA
    Am J Physiol Heart Circ Physiol 303:H1107-13. 2012
    Secondary lymphedema in humans is a common consequence of axillary lymph node dissection (ALND) to treat breast cancer...
  82. pmc Indocyanine green (ICG) lymphography is superior to lymphoscintigraphy for diagnostic imaging of early lymphedema of the upper limbs
    Makoto Mihara
    Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e38182. 2012
    Secondary lymphedema causes swelling in limbs due to lymph retention following lymph node dissection in cancer therapy...
  83. ncbi Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression
    Andrzej Szuba
    Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer 95:2260-7. 2002
    ..axillary lymph node dissection, with or without radiation therapy, reportedly is the most common cause of lymphedema in developed countries. There is no cure for breast carcinoma-associated lymphedema...
  84. pmc MR lymphography of lymphatic vessels in lower extremity with gynecologic oncology-related lymphedema
    Qing Lu
    Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e50319. 2012
    To characterize lymphatic vessel morphology in lower extremity lymphedema using MR lymphography at 3T.
  85. ncbi Complications of lymphadenectomy for gynecologic cancer
    A Achouri
    Service de Chirurgie Cancérologique Gynécologique et du Sein, Hopital Europeen Georges Pompidou, AP HP, Paris, France
    Eur J Surg Oncol 39:81-6. 2013
    Symptomatic postoperative lymphocysts (SPOLs) and lower-limb lymphedema (LLL) are probably underestimated complications of lymphadenectomy for gynecologic malignancies...
  86. ncbi Can a practicing surgeon detect early lymphedema reliably?
    Keiva L Bland
    Department of Surgery, School of Medicine, Wayne State University, Detroit, MI, USA
    Am J Surg 186:509-13. 2003
    b>Lymphedema may be identified by simpler circumference changes as compared with changes in limb volume.
  87. ncbi Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized study
    L Andersen
    Department of Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 39:399-405. 2000
    ..of manual lymphatic drainage (MLD) to the standard therapy could improve treatment outcome in women with lymphedema of the ipsilateral arm after breast cancer treatment...
  88. ncbi A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011
    Bonnie B Lasinski
    Lymphedema Therapy and The Boris Lasinski School, Woodbury, NY
    PM R 4:580-601. 2012
    To critically analyze the contemporary published research that pertains to the individual components of complete decongestive therapy (CDT), as well as CDT as a bundled intervention in the treatment of lymphedema.
  89. pmc An audit of the incidence of arm lymphoedema after prophylactic level I/II axillary dissection without division of the pectoralis minor muscle
    G Querci della Rovere
    Breast Unit, Royal Marsden NHS Trust, Sutton, Surrey, UK
    Ann R Coll Surg Engl 85:158-61. 2003
    ..When lymphoedema in any site was considered, right-sided treatment and nodal status were independently significant...
  90. pmc Breast cancer-related lymphedema: comparing direct costs of a prospective surveillance model and a traditional model of care
    Nicole L Stout
    National Naval Medical Center, Breast Care Center, Bethesda, MD 20814, USA
    Phys Ther 92:152-63. 2012
    ..Breast cancer treatment sequelae, such as lymphedema, may occur early or late and often negatively affect function...
  91. ncbi The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedema
    Abuzer Dirican
    Department of Surgery, Division of Surgical Oncology, Magee Womens Hospital University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Support Care Cancer 19:685-90. 2011
    Breast-cancer-related lymphedema (BCRL) is a chronic disease, and currently there is no definitive treatment for it. There are some therapeutic interventions targeted to decrease the limb swelling and the associated problems...
  92. pmc Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment
    David N Finegold
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 18:2382-90. 2012
    Secondary lymphedema is a frequent complication of breast cancer associated with surgery, chemotherapy, or radiation following breast cancer treatment...
  93. pmc Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema
    Joseph M Rutkowski
    Institute of Bioengineering, School of Life Sciences LMBM Station 15, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Am J Pathol 176:1122-9. 2010
    Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue...
  94. ncbi Efficacy of home-based lymphoedema management in reducing acute attacks in subjects with lymphatic filariasis in Burkina Faso
    Patrick Jullien
    Handicap International, 14 avenue Berthelot, 69007 Lyon, France
    Acta Trop 120:S55-61. 2011
    ..5 months). The lymphoedema management requires no additional human resources, but whether its effect can be sustained remains to be seen...
  95. pmc Impact of community-based lymphedema management on perceived disability among patients with lymphatic filariasis in Orissa State, India
    Philip J Budge
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS Negl Trop Dis 7:e2100. 2013
    ..As many as 40 million have symptoms of LF disease, including lymphedema, elephantiasis, and hydrocele. India constitutes approximately 45% of the world's burden of LF...
  96. ncbi Animal models for the study of lymphatic insufficiency
    William S Shin
    Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Lymphat Res Biol 1:159-69. 2003
    b>Lymphedema is the term commonly employed to describe the spectrum of pathological states that arise as a consequence of functional lymphatic insufficiency. These human disease entities currently lack an effective cure...
  97. ncbi The experience of lower limb lymphedema for women after treatment for gynecologic cancer
    Mary Ryan
    Gynaecological Cancer Centre of the Royal Hospital for Women, Randwick, New South Wales, Australia
    Oncol Nurs Forum 30:417-23. 2003
    To describe women's experiences with lower limb lymphedema to inform both preventive and management clinical practices.
  98. ncbi MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
    Microvasc Res 77:335-9. 2009
    To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
  99. pmc A contemporary, population-based study of lymphedema risk factors in older women with breast cancer
    Tina W F Yen
    Division of General Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Ann Surg Oncol 16:979-88. 2009
    We studied potential risk factors for lymphedema in a contemporary population of older breast cancer patients.
  100. ncbi A phase I study to assess the feasibility and oncologic safety of axillary reverse mapping in breast cancer patients
    Isabelle Bedrosian
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston Texas, USA
    Cancer 116:2543-8. 2010
    ..mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection...
  101. ncbi Evaluation of the clinical effectiveness of physiotherapeutic management of lymphoedema in palliative care patients
    Katri Elina Clemens
    Department of Science and Research, Centre for Palliative Medicine, University of Bonn, Bonn, Germany
    Jpn J Clin Oncol 40:1068-72. 2010
    ..The aim of the study was to evaluate the frequency and effect of manual lymphatic drainage in palliative care patients with lymphoedema in a far advanced stage of their disease...

Research Grants64

  1. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..The importance of this concept became clearer to us when we observed that mice with primary lymphedema, devoid of dermal lymphatic capillaries, unexpectedly had elevated levels of circulating plasma cholesterol...
  2. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..and swallowing defects, shoulder dysfunction, accelerated arteriosclerosis of the carotid, xerostomia, trismus, lymphedema and neck muscle fibrosis...
  3. The Role of Connexin32 in the Pathogensis of CMTX
    STEVEN SIMON SCHERER; Fiscal Year: 2013
    ..1. Investigate the molecular defects of hCx47 mutants causing PMLD or familial lymphedema. In the last grant cycle of this grant, we showed that 3 recessive Cx47 mutants associated with PMLD have ..
  4. Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer Survivors
    Sheila H Ridner; Fiscal Year: 2013
    ..exist as PT is: 1) short-term and does not address MSI changes over time secondary to progressing fibrosis and lymphedema as noted in our current study, 2) conducted at facility-based centers with less emphasis and monitoring of home ..
  5. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..5 million breast cancer survivors in the U.S. more than 40% of them have developed lymphedema (LE)...
  6. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    Over ten million people in the US currently suffer from some form of lymphedema, including a high percentage of patients recovering from mastectomy or reconstructive surgery...
  7. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..of disease states, including chronic kidney disease (CKD), congestive heart failure (CHF), liver failure, and lymphedema. Currently, serial physical examinations by a skilled clinician provide the input for clinical decision making...
  8. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    ..Following the treatment with radiation and surgery, cancer patients frequently develop lymphedema. While in the US about 3 million patients develop lymphedema as a result of cancer therapy, the major cause of ..
  9. Psychosexual Intervention for Gynecologic Cancer Patients
    Barbara L Andersen; Fiscal Year: 2012
    ..patients, one of the most disruptive and long-lasting sources of morbidity is sexual, second only to extremity lymphedema. Over 50% of patients have moderate-to-severe sexual disruption, as documented with 30+ years of descriptive ..
  10. Lymphotoxin: Regulation and Biologic Function
    NANCY RUDDLE; Fiscal Year: 2009
    ..of the factors that can induce lymphangiogenesis and thus provide therapeutic insight into the pathology of lymphedema. The data will suggest modalities for treatment of lymphatic vessel insufficiency by controlled local ..
  11. Characterization of lymphatic contraction during infection
    Timothy P Padera; Fiscal Year: 2013
    ..Chronic infections, such as in cellulitis, are frequently associated with lymphedema, which is generally associated with malfunctions or disruptions in the function of collecting lymphatic vessels...
  12. Disseminating PAL
    Kathryn H Schmitz; Fiscal Year: 2012
    ..S. today. As a common and morbid effect of BrCa treatment, lymphedema ranks principal among concerns of long-term survivors...
  13. Short-Term Institutional Research Training Grant
    Marlys Hearst Witte; Fiscal Year: 2013
    ..g. heart failure, developmental abnormalities, cardiac arrest/resuscitation, transplantation, artificial hearts, lymphedema-angiodysplasia syndromes);cancer (e.g...
  14. The Fibrosis-Lymphedema Continuum in Head and Neck Cancer
    Sheila H Ridner; Fiscal Year: 2013
    ..Fibrosis and lymphedema secondary to the stromal response to [tissue damage from tumor or treatment are understudied and poorly ..
  15. Role of CCBE1 in lymphangiogenesis
    DAVID RICHARD ENIS; Fiscal Year: 2013
    ..to be mutated in patients with a severe inherited form of swelling in their skin and intestines known as "Lymphedema-lymphangiectasia-mental retardation syndrome" or Hennekam Syndrome...
  16. Role of a9b1 Integrin in lymphangiogenesis
    Nicholas E Vlahakis; Fiscal Year: 2010
    ..largely been ignored, however recently it has become clear this has been a mistake since human diseases such as lymphedema are clearly associated with genetic abnormalities of the VEGF control system for the lymphatic vessels...
  17. Early Detection and Treatment of Lymphedema in Women with Breast Cancer
    Alphonse G Taghian; Fiscal Year: 2013
    b>Lymphedema, a swelling of the upper extremity due to an accumulation of protein rich interstitial fluid, significantly impacts the quality of life of patients who develop this complication following their treatment for breast cancer...
  18. Endogenous Specific Inhibitor of Corneal Lymphangiogenesis
    Jayakrishna Ambati; Fiscal Year: 2013
    ..The impact of these studies also extends to pathological states such as tumor metastasis, lymphedema, and lymphangioma, which can be better studied and possibly treated by modulating the endogenous uncoupler of ..
  19. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2013
    ..diseases alone since lymphatic dysfunction is associated with a diverse array of diseases and conditions, which include but are not limited to cancer metastasis, inflammation, infections, diabetes, obesity, hypertension and lymphedema.
  20. Quantifying the role of load-induced remodeling in lymphedema progression
    JAMES BRANDON DIXON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recent estimates suggest that the prevalence of lymphedema in developed countries is as high as 1.44 per thousand persons...
  21. 2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease
    GUILLERMO C OLIVER; Fiscal Year: 2012
    ..surveillance and lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in ..
  22. Therapeutic Lymphatic Collecting Vessel Regeneration by Directed Fluid Flow
    Jeremy Goldman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Secondary lymphedema is often acquired as a consequence of axillary dissection, performed in an effort to treat breast cancer...
  23. Role of Neuropilin receptors in lymphangiogenesis
    ANNE CHRISTINE EICHMANN; Fiscal Year: 2013
    ..impaired lymphatic vessel development causes fluid and protein accumulation in the interstitium, resulting in lymphedema and a persistent inflammatory response...
  24. Imaging lymph function in humans and in a murine model of lymphedema
    Eva M Sevick-Muraca; Fiscal Year: 2012
    ..the diagnosis and management of lymph diseases in a population of patients who suffer from primary and secondary lymphedema. In this research application, we hypothesize that: near infrared (NIR) optical methods can be used to image ..
  25. Molecular Targeting of Lymphatic Endothelial Receptors for Ligand-directed Imagin
    RENATA contact PASQUALINI; Fiscal Year: 2010
    ..vasculature plays a critical role in the pathogenesis of many diseases including inflammatory disorders, lymphedema, tumor progression, and metastasis...
  26. Southern Community Cancer Survivorship Study
    Ann Marie Flores; Fiscal Year: 2010
    ..limitations and symptoms (shoulder range of motion &strength, ability to accomplish functional tasks, lymphedema, pain, fatigue) than non-minorities. H1...
  27. Mechanisms of fibrosis and lymphatic dysfunction in post-surgical lymphedema
    BABAK MEHRARA MEHRARA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lymphedema is the accumulation of protein rich fluid in tissues, and in the US, occurs most commonly as a surgical complication of cancer treatment...
  28. RASA1-mediated control of lymphatic vessel growth and function
    Philip D King; Fiscal Year: 2012
    ..by which the growth and function of lymphatic vessels can be manipulated to clinical benefit in diseases such as lymphedema and cancer...
  29. Therapy for Secondary Lymphedema in Breast Cancer
    Annissa Furr; Fiscal Year: 2013
    ..radical mastectomy and sentinel lymph node removal during the treatment of breast cancer is the development of lymphedema in related limbs...
  30. Biomarkers for the Detection of Lymphatic Vascular Insufficiency
    Stanley G Rockson; Fiscal Year: 2010
    ..Acquired lymphatic vascular dysfunction (lymphedema) is a common, chronic, debilitating disease that is frequently under-recognized or misdiagnosed, and many ..
  31. The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and
    Richard R Barakat; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The proposed study, "Lymphedema and Gynecologic cancer (LEG): Incidence, Risk Factors and Impact", will innovatively utilize the cooperative group setting of the GOG (Gynecologic Oncology Group) to ..
  32. Genetic investigation of Notch signaling in lymphatic endothelium
    Mark L Kahn; Fiscal Year: 2010
    Defects in lymphatic vessel growth cause human lymphedema while tumor-induced lymphangiogenesis provides a route for tumor metastasis...
  33. Lymphatic Radiobiology
    Timothy P Padera; Fiscal Year: 2013
    Axillary radiation with surgery in breast cancer patients often leads to lymphedema, which affects nearly 400,000 women in the United States. Lymphedema is disfiguring, painful and forms a nidus for infection...
  34. Long-term Arm Morbidity Following Breast Cancer Treatment
    Christine A Miaskowski; Fiscal Year: 2010
    ..The specific aims of the proposed study are to: determine the prevalence, severity, and the timing of the lymphedema (LE);determine the prevalence and timing of occurrence of changes in shoulder mobility and changes in grip ..
  35. Bioelectrical Impedance for Self-Monitoring of Breast Cancer Related Lymphedema
    Sheila H Ridner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Breast cancer treatment-related lymphedema (swelling) is an incurable, chronic condition experienced by a significant percentage of breast cancer survivors...
  36. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
    ..Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2...
  37. HGF and MET Mutations in Primary Lymphadema
    ROBERT EDWARD contact FERRELL; Fiscal Year: 2010
    Primary lymphedema is the cl inical expression of defects in lymphatic development and function. Three genes have been shown to cause primary lymphedema, VEGFR3, FOXC2 and SOX18...
  38. Prox1 in Mammalian Lymphangiogenesis
    GUILLERMO C OLIVER; Fiscal Year: 2013
    ..Malfunctions of the lymphatic system can lead to congenital or inherited disorders such as lymphedema, a disfiguring and disabling disorder that is caused by imbalance in lymph absorption and often characterized by ..
  39. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..As with many other developmental pathways, genes involved in hereditary lymphedema can provide important insights into the molecular events involved in lymphangiogenesis...
  40. Bone Morphogenic Protein Signaling in Lymphatic Endothelial Cells
    Suk Won Jin; Fiscal Year: 2013
    ..significant both in increasing our basic understanding of how lymphatic development is coordinated and provide a theoretical background in developing therapeutic interventions for lymphedema and other dysfunctions of lymphatic vessels.
  41. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..leads to abnormalities in mucosal lymphatics that impair fluid drainage, and could lead to bronchial lymphedema, which worsens airway obstruction and perturbs immune responses by altering the normal balance of fluid/cell ..
  42. 2010 Molecular Mechanisms in Lymphatic Function and Disease Gordon Research Confe
    Michael J Detmar; Fiscal Year: 2010
    ..This has lead to new insights into diseases such as cancer, cardiovascular diseases, chronic inflammation and lymphedema (both congenital and surgery-induced)...
  43. Cyber Informatics Tools for Lymphedema Stakeholders
    Chi Ren Shyu; Fiscal Year: 2012
    ..provided by applicant): Researchers and clinicians seek to improve outcomes for patients with and at risk for lymphedema (LE), a chronic, progressive disease of the lymphatic system, often starting with seemingly innocuous ..
  44. SYNDECAN FUNCTION IN ENDOTHELIAL CELLS
    Michael Simons; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abnormal lymphangiogenesis leading to lymphedema is a common disorder afflicting tens of millions of individuals throughout the world...
  45. MASSAGE THERAPY FOR EXPERIMENTAL LYMPHEDEMA
    Marlys Witte; Fiscal Year: 2002
    DESCRIPTION (Applicant's Abstract): Massage therapy (in the form of Manual Lymph Drainage (MLD) or Manual Lymphedema Treatment (MLT) is an integral component of the international consensus-recommended optimal treatment for lymphedema(LE) ..
  46. INTRAOPERATIVE OCT FOR DETERMINING LYMPH NODE STATUS AND STAGING CANCER
    Stephen A Boppart; Fiscal Year: 2013
    ..the surgical removal of lymph nodes, to reduce costs, and most importantly, to reduce or eliminate the risks of lymphedema, a highly morbid and lifelong complication from the surgical treatment of many types of cancer...
  47. Lymphatic Fluid Flow Modeling with Active Network Components
    James E Moore; Fiscal Year: 2012
    ..This system is also part of the primary transport mechanism for the immune system. Lymphedema, a debilitating disease for which there is no known cure, affects a large number of cancer patients who have ..
  48. NYU Center for the Study of Asian American Health
    Chau Trinh-Shevrin; Fiscal Year: 2013
    ..The second research project tests the efficacy of a pilot intervention to reduce the risk of lymphedema among Chinese breast cancer survivors and improve quality of life and health issues for these women...
  49. Pycnogenol for Treatment of Arm Lymphedema
    Paul Hutson; Fiscal Year: 2004
    b>Lymphedema of the arm affects the function and self-image of approximately 600,000 of the 2 million breast cancer survivors in the United States...
  50. BRUGIAN FILARIASIS IN THE FERRET
    CATHERINE CRANDALL; Fiscal Year: 1990
    ..of two manifestations of infection: tropical filarial eosinophilia (occult filariasis) and chronic lymphedema. The ferret (Mustela putorius furo) infected with Brugia malayi will be used as an experimental model...
  51. Shear Stress & Cellular Control of Capillary Function
    Donna Williams; Fiscal Year: 2005
    ..Chronic venous insufficiency, congestive heart failure, and lymphedema represent three human diseases where the capillary barrier is not functioning properly and mechanical ..
  52. MOLECULAR CHARACTERIZATION OF FAMILIAL LYMPHEDEMA
    Mansoor Sarfarazi; Fiscal Year: 2003
    DESCRIPTION (Adapted from investigator's abstract): Primary lymphedema is a condition in which there is a deficiency of lymphatic drainage, leading to swelling, frequent recurrent cellulites, and disfigurement of the affected limb or ..
  53. Control of lymphatic endothelial differentiation program
    Kari Alitalo; Fiscal Year: 2006
    ..Absent or damage lymphatic vessels lead to lymphedema, a chronic and disfiguring swelling of the extremities...
  54. Massage Therapy for Breast Cancer-related Lymphedema
    Michael Bernas; Fiscal Year: 2003
    ..of Combined Physical Therapy (CPT), the international consensus-recommended optimal treatment for peripheral lymphedema (LE)...
  55. Lymphatic Radiobiology
    TIMOTHY PADERA; Fiscal Year: 2009
    Axillary radiation with surgery in breast cancer patients often leads to lymphedema, which affects nearly 400,000 women in the United States. Lymphedema is disfiguring, painful and forms a nidus for infection...
  56. NURSING MEASUREMENT OF LYMPHEDEMATOUS LIMBS
    Jane Armer; Fiscal Year: 2000
    DESCRIPTION: Breast cancer treatment is the leading cause of lymphedema in the United States. Two million women with breast cancer are at risk to develop lymphedema during their lifetimes...
  57. CONQUERING LYMPHATIC DISEASE--SETTING THE RESEARCH AGEND
    Marlys Witte; Fiscal Year: 2000
    ..Three conferences are planned: 1) Year 1- Lymphatic Vascular Biology and Lymphedema-Angiodysplasia Syndromes will engage scientists from around the world in exploring and characterizing the state-..
  58. Arm lymphedema in female breast cancer cases diagnosed in Iowa
    Rebecca Tsai; Fiscal Year: 2009
    ..of breast cancer have improved survival, consequentially increasing a potentially serious complication called lymphedema. Lymphedema, characterized by painful swelling of the arm, affects 3- 60% of breast cancer survivors, leading to ..
  59. Integrated optical imaging rat of mesentery
    Vladimir Zharov; Fiscal Year: 2004
    ..states and under different interventions, such as drug or radiation therapy; modeling of experimental lymphedema; optimization of laser treatment of vascular lesions, and so on. The Specific Aims are to: Specific Aim 1...
  60. Ultrasound Load-Indentor for Tissue Characterization
    MARY GEYER; Fiscal Year: 2001
    ..and beta-testing for sensitivity and specificity of the device in human subjects with venous disease and lymphedema. It is our intent to manufacture, market and distribute the device or to license the rights to a third party...
  61. The Impact of Lymphedema on Overall and Local Functioning
    Marylin Dodd; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Arm lymphedema may arise at any time after breast cancer surgery and/or radiation therapy...
  62. : Real-time monitoring of lymphedema using self-reporting, sensors and mobile te
    PHD DASGUPTA; Fiscal Year: 2013
    The primary purpose is to develop a real-time method of monitoring lymphedema patients[unreadable] symptoms to be used with a smartphone or tablet when the patients are away from their clinic...
  63. The Lymphatic Continuum Conference
    Stanley Rockson; Fiscal Year: 2002
    ..the publication of a Program Announcement (PA-01-035) soliciting research into the Pathogenesis and Treatment of Lymphedema. It is, therefore, a specific goal of this conference to foster awareness of this program announcement, through ..
  64. Molecular Mechanisms in Lymphatic Function & Disease
    Stanley Rockson; Fiscal Year: 2004
    ..The physiology and human genetics of the lymphatic system will be explored and there will be a focus upon mechanisms of cancer metastasis and its relationship to lymphatic function and lymphangiogenesis. ..