leukopenia

Summary

Top Publications

  1. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
  2. ncbi Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study
    Jae Hak Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Goyang si, Korea
    J Clin Gastroenterol 44:e242-8. 2010
  3. ncbi Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7
    Rafael Correa-Rocha
    Laboratorio de Inmunobiologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatr Res 71:590-7. 2012
  4. ncbi Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis
    Y Ando
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Cancer Res 60:6921-6. 2000
  5. pmc Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys
    Yongping Jiang
    Fanzhou Biopharmagen Corporation, Suzhou, China
    J Hematol Oncol 4:28. 2011
  6. ncbi Severe leukopenia and liver biochemistry changes in adult rabbits after calicivirus infection
    P G Ferreira
    Department of Anatomy, ICBAS Abel Salazar Institute for Biomedical Sciences, University of Porto, Largo Professor Abel Salazar, 2, Porto 4099 003, Portugal
    Res Vet Sci 80:218-25. 2006
  7. ncbi Analysis of leukopenia and anemia after gastric bypass surgery
    Ramsey M Dallal
    Department of Surgery, Albert Einstein Medical Center, Elkins Park, Pennsylvania, USA
    Surg Obes Relat Dis 8:164-8. 2012
  8. pmc Prompt and successful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leukocidin genes
    Nicolas Rouzic
    Universite de Lyon, INSERM U851, Faculté de médecine Lyon Est, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Clin Microbiol 48:1952-5. 2010
  9. pmc Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia
    Donald C Vinh
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:1519-29. 2010
  10. ncbi Detection of a novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome in Henan Province, China, using real-time reverse transcription PCR
    XueYong Huang
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, 450016, PR China
    J Med Microbiol 62:1060-4. 2013

Detail Information

Publications245 found, 100 shown here

  1. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
    Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports of tick bites suggested that infection could contribute to FTLS...
  2. ncbi Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study
    Jae Hak Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Goyang si, Korea
    J Clin Gastroenterol 44:e242-8. 2010
    ..to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.
  3. ncbi Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7
    Rafael Correa-Rocha
    Laboratorio de Inmunobiologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Pediatr Res 71:590-7. 2012
    ..However, the risk of neonatal death in preterm infants is much greater than in full-term neonates and is frequently associated with infections...
  4. ncbi Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis
    Y Ando
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Cancer Res 60:6921-6. 2000
    Irinotecan unexpectedly causes severe toxicity of leukopenia or diarrhea. Irinotecan is metabolized to form active SN-38, which is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) 1A1 enzyme...
  5. pmc Effect of a structurally modified human granulocyte colony stimulating factor, G-CSFa, on leukopenia in mice and monkeys
    Yongping Jiang
    Fanzhou Biopharmagen Corporation, Suzhou, China
    J Hematol Oncol 4:28. 2011
    ..Therefore, there is a need for the development of G-CSF derivatives that are more stable and active in vivo...
  6. ncbi Severe leukopenia and liver biochemistry changes in adult rabbits after calicivirus infection
    P G Ferreira
    Department of Anatomy, ICBAS Abel Salazar Institute for Biomedical Sciences, University of Porto, Largo Professor Abel Salazar, 2, Porto 4099 003, Portugal
    Res Vet Sci 80:218-25. 2006
    ..No significant changes in blood parameters were observed in most of the rabbits up to 18 h of infection. Severe leukopenia was seen 6h before death of the infected rabbits; both heterophils and lymphocytes contributed to the decrease ..
  7. ncbi Analysis of leukopenia and anemia after gastric bypass surgery
    Ramsey M Dallal
    Department of Surgery, Albert Einstein Medical Center, Elkins Park, Pennsylvania, USA
    Surg Obes Relat Dis 8:164-8. 2012
    ..Although anemia is a well-described complication after Roux-en-Y gastric bypass (RYGB) in association with iron deficiency, no studies have been published regarding changes in the white blood cell count...
  8. pmc Prompt and successful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leukocidin genes
    Nicolas Rouzic
    Universite de Lyon, INSERM U851, Faculté de médecine Lyon Est, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Clin Microbiol 48:1952-5. 2010
    ..due to Panton-Valentine leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3x10(9)/liter in all three cases and hemoptysis in two cases) were successfully treated with ..
  9. pmc Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia
    Donald C Vinh
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 115:1519-29. 2010
    ..This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern...
  10. ncbi Detection of a novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome in Henan Province, China, using real-time reverse transcription PCR
    XueYong Huang
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, 450016, PR China
    J Med Microbiol 62:1060-4. 2013
    A novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome (FTLS) was discovered in Henan Province, China...
  11. ncbi Responsiveness to G-CSF before leukopenia predicts defense to infection in high-dose chemotherapy recipients
    Christian Straka
    Medizinische Klinik Innenstadt, Klinikum der Universitat Munchen, Munchen, Germany
    Blood 104:1989-94. 2004
    ..Notably, the result of testing G-CSF responsiveness was opportunely available before the onset of leukopenia, and G-CSF responsiveness was more informative than neutropenia duration regarding the risk of infection...
  12. ncbi Vitamins C and E prevent AZT-induced leukopenia and loss of cellularity in bone marrow. Studies in mice
    J García-de-la-Asunción
    Department of Anaesthesiology and Surgical Critical Care, Hospital Clinic University, Valencia, Spain
    Free Radic Res 41:330-4. 2007
    A major limitation in the use of AZT for AIDS treatment is the occurrence of side effects, such as leukopenia. The effects of antioxidant vitamins C and E on AZT-induced leukopenia were investigated in mice...
  13. ncbi Non-life-threatening leukopenia in a renal transplant recipient with acute overdose of mycophenolate mofetil
    S W Wu
    Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Transplant Proc 40:3770-1. 2008
    ..Herein we have reported a 40-year-old female kidney recipient with moderate leukopenia and lack of gastrointestinal toxicity following ingestion of 25 g MMF, which was confirmed by serum drug levels...
  14. ncbi Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents
    Aminur Rahman
    Dallas Metrocare Services, Dallas, TX, USA
    Ann Pharmacother 43:822-30. 2009
    At the Austin State Hospital, Austin, TX, a number of cases of neutropenia and leukopenia have been observed in children and adolescents who were treated with the combination of valproate and quetiapine...
  15. ncbi The risk of amenorrhoea after adjuvant chemotherapy for early stage breast cancer is related to inter-individual variations in chemotherapy-induced leukocyte nadir in young patients: data from the randomised SBG 2000-1 study
    Mikkel Rosendahl
    The Fertility Clinic and Laboratory of Reproductive Biology, Copenhagen University Hospital Rigshospitalet, Denmark
    Eur J Cancer 45:3198-204. 2009
    ..Amenorrhoea is a common side-effect to chemotherapy of premenopausal women. We examine the association between chemotherapy-induced leucopaenia and the development of amenorrhoea in premenopausal women with breast cancer...
  16. pmc Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia
    Wei Chung Liu
    The Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 101 Sec 2, Kuang Fu Road, Hsinchu 30013, Taiwan
    Exp Biol Med (Maywood) 233:447-55. 2008
    ..In summary, CS enhances recovery of mice from leukopenia caused by Taxol treatment...
  17. ncbi Reduction of leukopenia in mice by "viscum album" administration during radiation and chemotherapy
    G Kuttan
    Amala Cancer Research Centre, Amala Nagar Thrissur, Kerala, India
    Tumori 79:74-6. 1993
    ..The results indicated that treatment with "Viscum album" extract reduces lymphocytopenia and hence could be used along with chemotherapy and radiation therapy...
  18. ncbi Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using zoledronic acid and docetaxel
    Hideyo Miyazaki
    Department of Urology, The University of Tokyo Hospital, Tokyo, Japan
    BJU Int 110:E520-5. 2012
    ..This study shows that the combination therapy of ZA and TAX increases the risk of ONJ and that tooth extraction and leukopenia induced by TAX are the risk factors.
  19. ncbi Mutations in the G6PC3 gene cause Dursun syndrome
    Siddharth Banka
    Genetic Medicine, St Mary s Hospital, Manchester Academic Health Sciences Centre MAHSC, University of Manchester, Manchester, UK
    Am J Med Genet A 152:2609-11. 2010
    ..We propose that Dursun syndrome should now be considered as a subset of severe congenital neutropenia type 4 with pulmonary hypertension as an important clinical feature...
  20. ncbi Familial pulmonary arterial hypertension, leucopenia, and atrial septal defect: a probable new familial syndrome with multisystem involvement
    Ali Dursun
    Faculty of Medicine, Department of Pediatrics, Metabolism and Nutrition Unit, Hacettepe University, Ankara, Turkey
    Clin Dysmorphol 18:19-23. 2009
    ..Investigations revealed a bone morphogenetic protein receptor 2 polymorphism in intron 4 in only one sibling, which was also present in unaffected maternal relatives...
  21. ncbi Omeprazole-induced leukopenia. A case report
    P Odou
    Laboratoire de Pharmacie Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France
    J Clin Pharm Ther 24:317-21. 1999
    ..However, the drug has been associated with serious adverse reactions, including haemolytic anaemia and acute interstitial nephritis. More recently, an autoimmune syndrome induced by omeprazole has been described...
  22. ncbi [Effect of Shuanghuang Shengbai granule on radiotherapy or chemotherapy induced leukopenia in mice]
    Yun Hui Shen
    Department of Pharmacology, Shanghai University of Traditional Chinese Madicine, Shanghai 201203, China
    Zhongguo Zhong Yao Za Zhi 30:1275-9. 2005
    To observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide (CTX) or radiation.
  23. ncbi Low insulin-like growth factor I and leukopenia in anorexia nervosa
    Nicoletta Polli
    Department of Medical Sciences, University of Milan, Milan, Italy
    Int J Eat Disord 41:355-9. 2008
    Considering that leukopenia and anemia are commonly observed in anorexia nervosa (AN) and that growth hormone (GH) and insulin-like growth factor-I (IGF-I) markedly influence the activation, growth and survival of hemopoietic cells, we ..
  24. ncbi Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease
    Liang Ding
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, PR China
    Inflamm Bowel Dis 18:63-73. 2012
    ..This study investigated the effects of TPMT and hypoxanthine guanine phosphoribosyltransferase (HPRT) activities on 6-thioguanine nucleotides (6-TGNs) concentrations and thiopurine-induced leukopenia in patients with IBD.
  25. ncbi Pharmacokinetics of acyclovir in immunocompromized children with leukopenia and mucositis after chemotherapy: can intravenous acyclovir be substituted by oral valacyclovir?
    Staffan Eksborg
    Karolinska Pharmacy, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Med Pediatr Oncol 38:240-6. 2002
    ..The aim of the present study was to compare the pharmacokinetics of acyclovir after intravenous administration and after oral administration of valacyclovir...
  26. ncbi Fever of unknown origin in febrile leukopenia
    Anastasia Antoniadou
    University General Hospital Attikon, Fourth Department of Internal Medicine, 1 Rimini Street, 12462 Athens, Greece
    Infect Dis Clin North Am 21:1055-90, x. 2007
    ..The need for targeted antimicrobial or antifungal prophylaxis and supportive strategies like the use of growth factors awaits further clarification...
  27. ncbi Dose-tailoring of FEC adjuvant chemotherapy based on leukopenia is feasible and well tolerated. Toxicity and dose intensity in the Scandinavian Breast Group phase 3 adjuvant Trial SBG 2000-1
    Per Edlund
    Department of Oncology, Gavle Hospital, Sweden
    Acta Oncol 50:329-37. 2011
    ..The study has included 1535 women with medium and high-risk breast cancer...
  28. ncbi Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials
    Weidong Lu
    Leonard P Zakim Center for Integrative Therapies, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Soc Integr Oncol 5:1-10. 2007
    Chemotherapy-induced leukopenia and neutropenia are common side effects during cancer treatment. Acupuncture has been reported as an adjunct therapy for this complication...
  29. ncbi Association of clinical complications with nutritional status and the prevalence of leukopenia among arsenic patients in Bangladesh
    Laila N Islam
    Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh
    Int J Environ Res Public Health 1:74-82. 2004
    ..in Bangladesh reports the relationship of clinical complications with nutritional status and the prevalence of leukopenia among arsenic exposed patients living in the rural villages...
  30. ncbi Post-marketing surveillance (PMS) of all patients treated with irinotecan in Japan: clinical experience and ADR profile of 13,935 patients
    Jun Ichi Tadokoro
    Yakult Honsha Co, Ltd, 4F Ginza Kobiki Bldg, 16 21, Ginza 7 Chome, Chuo Ku, Tokyo 104 0061, Japan
    Jpn J Clin Oncol 41:1101-11. 2011
    ..The actual condition of drug utilization and the adverse drug reactions profile of irinotecan hydrochloride hydrate (irinotecan), an antitumor drug, were examined on the basis of all the case survey results from April 1995 to January 2000...
  31. ncbi Trabectedin plus pegylated liposomal Doxorubicin in recurrent ovarian cancer
    Bradley J Monk
    University of California at Irvine UCI and UCI Medical Center, Orange, CA 92868 3298, USA
    J Clin Oncol 28:3107-14. 2010
    ....
  32. ncbi Leukopenia complicates cytomegalovirus prevention after renal transplantation with alemtuzumab induction
    Jennifer K Walker
    1 Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Transplantation 83:874-82. 2007
    ..Valganciclovir (VGCV) is commonly utilized for CMV prophylaxis but can cause leukopenia, with risk compounded by the use of myelosuppressive immunosuppression...
  33. ncbi Do cancer patients with chemotherapy-induced leukopenia benefit from an antiseptic chlorhexidine-based oral rinse? A double-blind, block-randomized, controlled study
    F A Pitten
    Institute of Hygiene and Environmental Medicine, University of Greifswald, Germany
    J Hosp Infect 53:283-91. 2003
    ..Patients were asked to rinse three times a day for 30s from the beginning of chemotherapy until the end of leukopenia. Before rinsing, as well as during and after leukopenia, aerobic and anaerobic bacteria in the oral cavity were ..
  34. ncbi Carcinoma of unknown primary site
    F A Greco
    Sarah Cannon Minnie Pearl Cancer Center, Centennial Medical Center, Nashville, TN 36203, USA
    Cancer 89:2655-60. 2000
    ....
  35. ncbi Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa
    Y Sheng
    Department of Cell and Molecular Biology, University of Lund, Sweden
    Phytomedicine 7:137-43. 2000
    ..In this study, the effect of C-Med-100 in the treatment of chemically induced leukopenia was evaluated in a rat model. W/Fu rats were treated first with doxorubicin (DXR) 2 mg/kg x 3 (i.p...
  36. ncbi Leukopenia in kidney transplant patients with the association of valganciclovir and mycophenolate mofetil
    S Brum
    Department of Transplantation, Hospital Curry Cabral, Lisbon, Portugal
    Transplant Proc 40:752-4. 2008
    ..Valganciclovir (VGC) is established for prophylaxis and treatment of CMV infections, but leukopenia which appears in 10% to 13% (severe in 4.9%) is the principal side effect...
  37. ncbi Possible leukopenia associated with long-term use of echinacea
    David Eric Kemp
    Northeastern Ohio University College of Medicine, Rootstown, USA
    J Am Board Fam Pract 15:417-9. 2002
  38. ncbi Monitoring mycophenolic acid pharmacokinetic parameters in liver transplant recipients: prediction of occurrence of leukopenia
    Chen Hao
    Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Liver Transpl 14:1165-73. 2008
    ..Forty-two patients (66.7%) had 52 episodes of MMF-related side effects, including leukopenia, diarrhea, and infection...
  39. ncbi Preventive and therapeutic effects of gene therapy using silica nanoparticles-binding of GM-CSF gene on white blood cell production in dogs with leukopenia
    Eun Wha Choi
    KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science, Seoul National University, Seoul, Republic of Korea
    Exp Hematol 36:1091-7. 2008
    ..Therefore, this study was conducted to determine whether treatment of canine GM-CSF gene/silica nanoparticles has preventive or therapeutic effects in dogs with leukopenia.
  40. ncbi KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice
    Tohru Noji
    Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Shizuoka, Japan
    J Pharmacol Exp Ther 300:200-5. 2002
    ..effects of KF24345 on lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha) production and leukopenia in mice. KF24345 (10 mg/kg p.o...
  41. pmc Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatment
    Nuntra Suwantarat
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Int J Med Sci 7:36-42. 2010
    ..To identify apparent adverse effects of treatment of chronic hepatitis C and their relationship to sustained virologic response (SVR)...
  42. ncbi [Multi-central clinical evaluation of ginger-partitioned moxibustion for treatment of leukopenia induced by chemotherapy]
    Xi xin Zhao
    The Third Affiliated Hospital, College of TCM of Henan, Zhengzhou 450008, China
    Zhongguo Zhen Jiu 27:715-20. 2007
    To prove the therapeutic effect of ginger-partitioned moxibustion on leukopenia induced by chemotherapy and effect on life quality of the patient with tumor after chemotherapy.
  43. pmc Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice
    Erjian Wang
    Infectious Diseases Research Center, Laval University, Quebec City, Canada G1V 4G2
    Infect Immun 70:4226-38. 2002
    ..Compared to the immunocompetent state, cyclophosphamide-induced leukopenia did not hamper interleukin-1 (IL-1), IL-6, macrophage inflammatory protein-1 (MIP-1), MIP-2, and monocyte ..
  44. ncbi [Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]
    Naohiro Nagayama
    Division of Respiratory Disease, National Organization Tokyo Hospital, 3 1 1, Takeoka, Kiyose shi, Tokyo 204 8585, Japan
    Kekkaku 79:341-8. 2004
    To examine the incidence rate by age and gender of leukopenia caused by chemotherapy including rifampicin (RFP) and isoniazid (INH), and to study the relationships between the leukopenia and the hepatic side effect or other haematological ..
  45. ncbi Leukopenia and thrombocytopenia caused by thiazolidinediones
    Colleen Digman
    Ann Intern Med 143:465-6. 2005
  46. ncbi Indirect-response model for the time course of leukopenia with anticancer drugs
    H Minami
    National Cancer Center Hospital East, Kashiwa, Japan
    Clin Pharmacol Ther 64:511-21. 1998
    Because both the nadir count and the duration of leukopenia after chemotherapy with anticancer drugs are important, a pharmacodynamic model describing the entire time course of leukopenia is valuable...
  47. pmc Definitive chemoradiotherapy for patients with malignant stricture due to T3 or T4 squamous cell carcinoma of the oesophagus
    K Kaneko
    Second Department of Internal Medicine, Showa University School of Medicine, 1 5 8, Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Br J Cancer 88:18-24. 2003
    ..The efficacy and survival of patients treated with this regimen are related to the T factor...
  48. pmc Leucocyte nadir as a marker for chemotherapy efficacy in node-positive breast cancer treated with adjuvant CMF
    P Poikonen
    Department of Oncology, Helsinki University Central Hospital, Finland
    Br J Cancer 80:1763-6. 1999
    ..A low leucocyte nadir during the adjuvant CMF chemotherapy is associated with favourable DDFS and it may be a useful biological marker for chemotherapy efficacy...
  49. ncbi Prolonged remission of severe Crohn's disease after fever and leukopenia caused by 6-mercaptopurine
    Efrat Z Lobel
    Section of Gastroenterology, Lenox Hill Hospital, New York, New York 10021, USA
    Dig Dis Sci 49:336-8. 2004
  50. ncbi Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia
    Øystein Wendelbo
    Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, University of Bergen, Norway
    Cancer Immunol Immunother 53:740-7. 2004
    ..3H-thymidine incorporation) of circulating T cells from AML patients with severe treatment-induced leukopenia, i.e., peripheral blood leukocyte counts < 0.5x10(9)/l...
  51. ncbi Surgical resection deteriorates gemcitabine-induced leukopenia in pancreatic cancer
    Masahide Onoue
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Int J Clin Oncol 9:174-8. 2004
    ..one of the most effective chemotherapeutic agents for pancreatic cancer; however, factors affecting GEM-induced leukopenia have not been clarified yet...
  52. ncbi Is leukopenia associated with divalproex and/or quetiapine?
    Preetha Nair
    Psychosomatics 46:188-9. 2005
  53. ncbi The usefulness of distal splenorenal shunt in children with portal hypertension for the treatment of severe thrombocytopenia and leukopenia
    Suk Bae Moon
    Department of Pediatric Surgery, Seoul National University Children s Hospital, Seoul, Korea
    World J Surg 32:483-7. 2008
    ..We reviewed the outcome of the use of DSRS in children to determine the usefulness of this operation...
  54. ncbi Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome
    Shamez Ladhani
    Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Br J Haematol 119:839-47. 2002
    ..Thus, leucocytosis was associated with both severity and mortality in children with falciparum malaria, irrespective of bacteraemia, whereas thrombocytopenia, although very common, was not associated with adverse outcome...
  55. ncbi Colchicine-induced leukopenia in a patient with familial Mediterranean fever: the cause and a possible approach
    E Ben-Chetrit
    Department of Medicine, Hadassah University Hospital, Jerusalem, POB12000, Israel
    Clin Exp Rheumatol 21:S38-40. 2003
    A young patient with familial Mediterranean fever (FMF) developed leukopenia each time she took colchicine. However, when she discontinued the drug the white cell and the platelets counts increased but she experienced FMF attacks...
  56. pmc Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitors
    Jinlu Dai
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 8940, USA
    Cancer Res 70:5014-23. 2010
    Hematopoietic growth factors are used to reverse chemotherapy-induced leukopenia. However, some factors such as granulocyte macrophage colony-stimulating factor (GM-CSF) induce osteoclast-mediated bone resorption that can promote cancer ..
  57. ncbi Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia
    I Shalit
    Schneider Children's Medical Center of Israel and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
    Eur J Haematol 66:287-96. 2001
    ..The effect was compared to that of G-CSF. Cyclophosphamide injection induced a severe leukopenia, with nadir at day 4 post-injection...
  58. ncbi Psychotropic medications and leukopenia
    Karim Sedky
    Drexel University College of Medicine, Philadelphia, PA, USA
    Curr Drug Targets 7:1191-4. 2006
    ..Blood cell count monitoring is encouraged on patients receiving clozapine as long as the drug is continued. Such evaluation is also advised on those medicated with other psychotropics, especially carbamazepine...
  59. ncbi Incidence of neoplasms in patients who develop sustained leukopenia during or after treatment with 6-mercaptopurine for inflammatory bowel disease
    William Disanti
    Department of Gastroenterology, Lenox Hill Hospital, New York, New York 10021, USA
    Clin Gastroenterol Hepatol 4:1025-9. 2006
    ..We have observed the occurrence of some neoplasms in IBD patients who developed sustained leukopenia as a result of treatment with 6-MP...
  60. ncbi Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone
    Tatsuya Ohno
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Gynecol Oncol 103:94-9. 2006
    To investigate the temporal patterns of anorexia, diarrhea, weight loss, and leukopenia in chemoradiation therapy (CRT) for cervical cancer compared with radiation therapy (RT) alone.
  61. ncbi Hematological side-effect profiles of individualized chemotherapy regimen for recurrent ovarian cancer
    Martina Breidenbach
    Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany
    Anticancer Drugs 14:341-6. 2003
    ..Generally, severe myelosuppression was rare. The highest incidence of leukopenia was seen in regimens with mitoxantrone/paclitaxel or gemcitabine/treosulfan, respectively...
  62. ncbi Clopidogrel-associated leukopenia
    Michelle W McCarthy
    Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA 22908 0674, USA
    Ann Pharmacother 37:216-9. 2003
    To report a case of leukopenia in a patient receiving clopidogrel following intracoronary stent placement.
  63. ncbi Vitamin E but not St. John's wort mitigates leukopenia caused by cancer chemotherapy in rats
    Richard F Branda
    Vermont Cancer Center, Burlington, VT 05401, USA
    Transl Res 148:315-24. 2006
    ..St. John's wort had neither a beneficial nor a detrimental effect on chemotherapy-induced toxicity...
  64. ncbi Clozapine-induced leukopenia successfully treated with lithium
    Eric C Kutscher
    College of Pharmacy, South Dakota State University, Sioux Falls, SD 57110, USA
    Am J Health Syst Pharm 64:2027-31. 2007
    A case of clozapine-induced leukopenia successfully treated with lithium is reported.
  65. ncbi Blunted cytopenias and weight loss: new correlates of virologic null response to re-treatment of chronic hepatitis C
    Karen L Lindsay
    Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Clin Gastroenterol Hepatol 6:234-41. 2008
    ..Although viral kinetic profiles in treatment responders shed light on the mechanism of action of interferon and ribavirin, minimal information is available to explain why some patients experience little or no virologic suppression...
  66. ncbi Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury
    S Bertuglia
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology, School of Medicine, University of Pisa, 56100 Pisa, Italy
    Am J Physiol Heart Circ Physiol 278:H755-61. 2000
    ..In conclusion, thrombus formation may be an additional and independent factor that with leukocyte-mediated mechanisms determines ischemia-reperfusion injury...
  67. ncbi Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia
    Kazuma Kiyotani
    Laboratory for Pharmacogenetics, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo 108 8639, Japan
    Cancer Sci 99:967-72. 2008
    ..To identify a genetic factor(s) determining the risk of docetaxel-induced leukopenia/neutropenia, we selected subjects who received docetaxel chemotherapy from samples recruited at BioBank Japan, ..
  68. ncbi Low serum C3, leukopenia, and thrombocytopenia: unusual features of henoch-schonlein purpura
    I Krause
    Nephrology Clinic and Dialysis Unit, Schneider Children s Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel
    Eur J Pediatr 158:906-9. 1999
    ..a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia...
  69. pmc Carboplatin-paclitaxel-induced leukopenia and neuropathy predict progression-free survival in recurrent ovarian cancer
    C K Lee
    NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, NSW 1450, Australia
    Br J Cancer 105:360-5. 2011
    We assess the prognostic value of chemotherapy-induced leukopenia and sensory neuropathy in the CALYPSO trial patients treated with carboplatin-paclitaxel (CP) or carboplatin-liposomal doxorubicin (CPLD).
  70. ncbi Pharmacodynamic modeling of the entire time course of leukopenia after a 3-hour infusion of paclitaxel
    H Minami
    National Cancer Center Hospital East, Kashiwa 277 8577, Japan
    Jpn J Cancer Res 92:231-8. 2001
    The entire time course of leukopenia after anticancer treatment is clinically more relevant than a singly measured nadir count...
  71. ncbi Trovafloxacin-associated leukopenia
    F A Mitropoulos
    Yale New Haven Hospital, New Haven, CT, USA
    Ann Pharmacother 35:41-4. 2001
    OBJECTIVE: To report a case of trovafloxacin-associated leukopenia, which occurred in a trauma patient shortly after administration and resolved following discontinuation of the drug...
  72. ncbi Phase II study of carboplatin-paclitaxel combination chemotherapy in elderly patients with advanced non-small cell lung cancer
    Isamu Okamoto
    Department of Respiratory Medicine, Kumamoto University, Kumamoto, Japan
    Jpn J Clin Oncol 35:188-94. 2005
    ..The efficacy and safety of carboplatin-paclitaxel combination chemotherapy in elderly patients with advanced NSCLC were evaluated in a phase II trial...
  73. ncbi [Clinical administration of oxaliplatin for patients previously treated for refractory advanced or recurrent colorectal cancer]
    Daisuke Takahari
    Center for Digestive Diseases, Dept of Medical Oncology, Tonan Hospital
    Gan To Kagaku Ryoho 33:49-54. 2006
    ..It is useful to combine L-OHP with high-dose continuous administration of 5-FU,namely FOLFOX regimens.FOLFOX 6 is the most useful of the FOLFOX regimens because it is simple and can be administered on an outpatient basis...
  74. ncbi A phase II study of docetaxel and cisplatin in patients with gastric cancer recurring after or progressing during 5-FU/platinum treatment
    Hawk Kim
    Department of Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Dong Gu, Ulsan 682 714, Korea
    Jpn J Clin Oncol 35:727-32. 2005
    ..We evaluated the feasibility of DP treatment in patients with recurring or metastatic gastric cancer who had been previously treated with other chemotherapy regimens...
  75. ncbi Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy
    Loren K Mell
    Department of Radiation and Cellular Oncology, University of Chicago and University of Illinois at Chicago, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 70:1431-7. 2008
    ....
  76. pmc Capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated tumours: results of an extended phase-I trial
    T Ernst
    Onkologisches Zentrum, III Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Br J Cancer 97:1475-9. 2007
    ..The established regimen was well tolerated and the preliminary efficacy data in this heavily pre-treated patients population appears to be promising...
  77. ncbi Evaluation of toxicities induced by chemotherapy in breast cancer patients
    Lubna Mehreen
    Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan
    Biomed Pharmacother 59:524-7. 2005
    ....
  78. ncbi The impact of dose per cycle of etoposide and cisplatin on outcomes in patients with extensive small-cell lung cancer
    Harvey B Niell
    Veterans Administration Medical Center, University of Tennessee Cancer Institute, Memphis, USA
    Clin Lung Cancer 5:299-302. 2004
    ..Variations in the administration of this regimen had no impact on outcomes in patients with extensive SCLC...
  79. ncbi [Clinical study of topotecan and cisplatin as first line chemotherapy in epithelial ovarian cancer]
    Li Hua Meng
    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China
    Zhonghua Fu Chan Ke Za Zhi 42:683-7. 2007
    ..To evaluate efficacy and toxicity of topotecan and cisplatin (TP) as first line chemotherapy in epithelial ovarian cancer, and its effect on prognosis of the patients...
  80. ncbi A phase II study of paclitaxel plus cisplatin chemotherapy in an unfavourable group of patients with cancer of unknown primary site
    Yeon Hee Park
    Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Jpn J Clin Oncol 34:681-5. 2004
    ..Efficacy was evaluated in terms of response rate, progression-free survival and overall survival...
  81. ncbi [Comparision of high dose impulsion and low dose density chemotherapeutic regimens with paclitaxel plus cisplatin in advanced NSCLC]
    Xin min Hua
    Department of Thorathic Surgery, Jilin Province Cancer Hospital, Changchun 130012, China
    Zhonghua Zhong Liu Za Zhi 26:621-5. 2004
    ..To explore high effective and low toxic chemotherapeutic regimens in the treatment of non-small-cell lung cancer (NSCLC)...
  82. ncbi Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors
    Otto Soepenberg
    Daniel den Hoed Cancer Center, Department of Medical Oncology, Erasmus University Medical Center Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Clin Cancer Res 11:1504-11. 2005
    ..To characterize the maximum-tolerated dose, recommended dose, dose-limiting toxicities (DLT), pharmacokinetic profile, and food effect of orally administered irinotecan formulated as new semisolid matrix capsules...
  83. ncbi [Cisplatin schedule in combination with gemcitabine in unresectable non-small cell lung cancer]
    Tadashi Ohara
    Dept of Respiratory Medicine, Shiga Medical Center for Adults
    Gan To Kagaku Ryoho 32:69-71. 2005
    ..Grade 3 leukopenia was 22%, and grade 3 neutropenia was 11%. No grade 4 hematological toxicities were observed...
  84. ncbi Gemcitabine and cisplatin combination chemotherapy in intrahepatic cholangiocarcinoma as second-line treatment: report of four cases
    Myung Ah Lee
    Division of Oncology, Department of Internal Medicine, Catholic University of Medical College, Seoul, Korea
    Jpn J Clin Oncol 34:547-50. 2004
    ..We investigated the efficacy and toxicity of the combination of gemcitabine and cisplatin as second-line chemotherapy in four patients with advanced, progressive intrahepatic cholangiocarcinoma...
  85. ncbi Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric cancer
    Ikuo Takahashi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 15:849-54. 2006
    ..The dose limiting toxicity of a combination of S-1 and biweekly DOC was leukopenia and neutropenia. The recommended dose for this combination in phase II study is DOC 35 mg/m2/day.
  86. ncbi Docetaxel and cisplatin as second-line chemotherapy for advanced non-small cell lung cancer
    Hironobu Hamada
    Dept of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Ehime
    Gan To Kagaku Ryoho 34:1235-9. 2007
    ..Docetaxel and cisplatin are both active against non-small cell lung cancer (NSCLC). This pilot study evaluated the efficacy and toxicity of docetaxel and cisplatin as second-line chemotherapy for patients with advanced NSCLC...
  87. ncbi [Concurrent chemoradiotherapy (CRT) with S-1 and cisplatin (CDDP) in patients (pts) with locally advanced head and neck cancer (HNC)]
    Makoto Tahara
    Division of Endoscopy and GI Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Gan To Kagaku Ryoho 33:167-71. 2006
    ..The Japan Clinical Oncology Group (JCOG) is planning a multicenter phase II study of concurrent chemoradiotherapy with S-1 and CDDP for locally advanced unresectable HNC...
  88. ncbi Induction chemotherapy, extrapleural pneumonectomy (EPP) and adjuvant hemi-thoracic radiation in malignant pleural mesothelioma (MPM): Feasibility and results
    Federico Rea
    Division of Thoracic Surgery, University of Padua, Policlinico di Padova, Italy
    Lung Cancer 57:89-95. 2007
    ..Trimodality therapy results have led us to test induction chemotherapy followed by EPP and adjuvant radiotherapy in stages I-III of MPM. The aim of our study was to evaluate the feasibility of this protocol and to estimate survival...
  89. ncbi [Preoperative chemotherapy with S-1 and low-dose cisplatin for oral squamous cell carcinoma]
    Mitsuhiro Nakazawa
    Second Dept of Oral and Maxillofacial Surgery, Osaka University, Faculty of Dentistry, Japan
    Gan To Kagaku Ryoho 33:184-8. 2006
    ..4%, anorexia 27.3%, neutropenia 25% and leukopenia 25%. Grade 3 and 4 adverse events were neutropenia 11.4%, leukopenia 9.1%, thrombocytopenia 4...
  90. ncbi Addition of topotecan to standard cisplatin/etoposide combination in patients with extended stage small cell lung carcinoma
    Faruk Tas
    Institute of Oncology, Istanbul University, Turkey
    Lung Cancer 57:79-83. 2007
    ..This study was designed to evaluate the efficacy and safety of a triplet combination with topotecan added to the standard PE regimen in previously untreated patients with ED-SCLC...
  91. ncbi Docetaxel/gemcitabine or cisplatin/gemcitabine followed by docetaxel in the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC): results of a multicentre randomized phase II trial
    D Binder
    Medizinische Klinik m S Infektiologie und Pneumologie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Cancer Chemother Pharmacol 60:143-50. 2007
    ..We therefore conducted a multicentre, prospectively randomized study that evaluates a sequential three-drug schedule and a platinum-free doublet regimen...
  92. ncbi Analysis of efficacy and toxicity of chemotherapy with cisplatin, 5-fluorouracil, methotrexate and leucovorin (PFML) and radiotherapy in the treatment of locally advanced squamous cell carcinoma of the head and neck
    Hideaki Katori
    Department of Otolaryngology, Yokohama City Minato Red Cross Hospital, and Yokohama City University Medical Center, Japan
    Cancer Chemother Pharmacol 59:789-94. 2007
    ....
  93. ncbi [Nedaplatin (NDP)-combination therapy (NDP/5-FU,NDP/S-1) for oral cancer]
    Yasubumi Maruoka
    Dept of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women s Medical University, Japan
    Gan To Kagaku Ryoho 34:713-7. 2007
    ..The present study evaluated the efficacy and safety of nedaplatin-combination therapy (NDP/5-FU [5-FU arm] or NDP/S-1 [S-1 arm] ) for the treatment of oral squamous cell carcinoma...
  94. ncbi [Docetaxel combined with cisplatin in the treatment of anthracycline-resistant advanced breast cancer]
    Bing He Xu
    Department of Medical Oncology, Cancer Hospital Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 28:471-3. 2006
    ..To evaluate the efficacy and safety of combination chemotherapy of Docetaxel (Taxotere, TXT) combined with cisplatin (DDP) for anthracycline (ANT)-resistant advanced breast cancer (ABC)...
  95. ncbi [Irinotecan plus oral S-1 in patients with advanced colorectal cancer--biweekly IRIS regimen]
    Yoshito Komatsu
    Third Dept of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Gan To Kagaku Ryoho 33:131-4. 2006
    ..Combination therapy with CPT-11 and S-1 achieved a high response rate and could be given safely. These findings suggest that the therapy has potential as first-line treatment for inoperable advanced recurrent colorectal cancer...
  96. ncbi [S-1 as a single agent for colorectal cancer]
    Takako Eguchi
    Dept of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gan To Kagaku Ryoho 33:121-4. 2006
    ..S-1 with molecular targeting drugs will also be studied. Therefore, S-1 is expected to play an important part in chemotherapy for colorectal cancer...
  97. ncbi A pharmacokinetic interaction study of docetaxel and cisplatin plus or minus 5-fluorouracil in the treatment of patients with recurrent or metastatic solid tumors
    A Felici
    Department of Medical Oncology, Erasmus University Medical Center Daniel Den Hoed, Groene Hilledijk 301, 3075, Rotterdam, The Netherlands
    Cancer Chemother Pharmacol 58:673-80. 2006
    ..The purpose of this study was to look at the pharmacokinetics of docetaxel, cisplatin-derived platinum and 5-fluorouracil (5-FU), when used in combination, to exclude potential clinically relevant pharmacokinetic interactions...
  98. ncbi Phase I/II trial of biweekly docetaxel and cisplatin with concurrent thoracic radiation for stage III non-small-cell lung cancer
    Yoshinobu Iwasaki
    Division of Pulmonary Medicine, Department of Medicine, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, 602, Kyoto, Japan
    Cancer Chemother Pharmacol 58:735-41. 2006
    ..Our objectives were to define the maximum-tolerated dose and dose-limiting toxicity (DLT) in the phase I study, and to determine the response rate, toxicity, and survival rate at the recommended dose (RD) in the phase II study...
  99. ncbi [A case of adenocarcinoma of the lung significantly responding to TS-1 plus cisplatin combination chemotherapy]
    Hiroshi Wataya
    Dept of Thoracic Oncology, National Kyushu Cancer Center
    Gan To Kagaku Ryoho 33:501-3. 2006
    ..0). Grade 2 leukopenia and neutropenia were observed, and non-hematologic toxicities were also mild...
  100. ncbi Adverse events of MVAC chemotherapy in patients with advanced urothelial cancer of the bladder
    Toshihiro Maeda
    The Department of Urology, Sapporo Medical University School of Medicine
    Hinyokika Kiyo 53:213-9. 2007
    ..Grade 3 or 4 neutropenia was seen in 60-75% of patients. Grade 3 or 4 leukopenia and/or neutropenia in the first course of the chemotherapy was associated with patients with impaired renal ..
  101. ncbi Repetitive short-course hepatic arterial infusion chemotherapy with high-dose 5-fluorouracil and cisplatin in patients with advanced hepatocellular carcinoma
    Jun Yong Park
    Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Cancer 110:129-37. 2007
    ..The objective of the current study was to evaluate the efficacy and safety of repetitive HAIC with high-dose 5-fluorouracil (5-FU) and cisplatin given for 3 days in patients with advanced HCC...

Research Grants60

  1. Molecular Mechanisms of Myelokathexis
    Andrew Aprikyan; Fiscal Year: 2009
    ..Myelokathexis is a rare congenital autosomal dominant disorder characterized by severe chronic neutropenia or leukopenia. The patients have extremely low levels of leukocytes, particularly 9 mature neutrophils in peripheral ..
  2. Treatment of Cytomegalovirus by Inhibition of Host Lipid Synthesis
    Bryson D Bennett; Fiscal Year: 2012
    ..Marketed CMV antivirals such as ganciclovir cause fever, diarrhea, and/or leukopenia in the majority of treated adults, and are teratogenic in pregnancy...
  3. A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis
    Ying Zheng; Fiscal Year: 2013
    ..Dysregulation of blood cell production leads to severe anemia, leukopenia, and thrombocytopenia, and produces substantial morbidity and mortality...
  4. A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of
    Mitchell W Mutz; Fiscal Year: 2013
    ..AmB causes severe toxicities including nephrotoxicity and leukopenia, and is not available in an oral formulation...
  5. Alcohol, Septicemia and the LKS Cell Response
    Ping Zhang; Fiscal Year: 2013
    ..Many alcoholic patients with severe bacterial infection present with leukopenia, which is frequently fatal...
  6. Epigenetic control of hematopoietic stem cells
    Hans B Sieburg; Fiscal Year: 2012
    ..Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells...
  7. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..HGE is a systemic febrile illness often accompanied by hematological abnormalities including leukopenia and thrombocytopenia...
  8. MECHANISMS OF RADIATION SUPPRESSED CORNEAL ANGIOGENESIS
    MARK SCROGGS; Fiscal Year: 1991
    ..This is presumed to be largely secondary to radiation induced leukopenia which impairs the leukocytic infiltration into the cornea and to a lesser extent due to the effect of ..
  9. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..3) Preventing leukocyte adhesion (via leukopenia), in addition to AGE, RAGE or NFkB blockade, will prevent ERT-associated exacerbation of ischemic brain damage...
  10. Ultrasound imaging and enhanced therapeutic response
    Katherine W Ferrara; Fiscal Year: 2013
    ..dose within primary tumors and the draining lymph nodes while decreasing systemic toxicity and avoiding leukopenia, 2) ultrasound ablation enhances the local CD8+ T cell population and dendritic and NK cell populations and 3) ..
  11. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2007
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  12. Lethality of H5N1 Influenza Virus is Linked to TGF-beta
    Stacey Schultz Cherry; Fiscal Year: 2009
    ..resulted in lethal disease characterized by decreased apoptosis in the lung, delayed viral clearance, and leukopenia. When considered together, these results suggested that TGF-beta induction might be a critical factor in ..
  13. SUPPRESSION OF HEMOPOIESIS BY A NOVEL LYMPHOKINE
    David Tweardy; Fiscal Year: 1990
    ..blood and bone marrow samples from patients at risk for infection because of aplastic anemia and unexplained leukopenia will be examined for CIL levels...
  14. Non-toxic Human Interferon-Alpha Analog
    Lorelie Villarete; Fiscal Year: 2004
    ..doses they produce frequent and sometimes serious side effects, including fever, myalgia, CNS effects and leukopenia, which limit their use...
  15. MECHANISM OF HEMATPOIETIC SUPPRESSION IN HIV-1 INFECTION
    Ronald Hoffman; Fiscal Year: 1993
    ..human immunodeficiency virus type-I (HIV-1) is complicated by a variety of hematological abnormalities including leukopenia, anemia and thrombocytopenia...
  16. MECHANISMS OF NEUTROPHIL ADHERENCE
    Robert Webster; Fiscal Year: 1990
    ..host defense to infection, the intensified adhesiveness and aggregation of neutrophils noted with hemodialysis leukopenia has been suggested to result in the development of acute lung injury by virtue of increased sequestration and ..
  17. SEEKING DRUGS THAT INCREASE KIT LIGAND GENE EXPRESSION
    Casey Case; Fiscal Year: 1992
    ..for therapeutic utility in combination with other hematopoietic growth factors for the treatment of anemia and leukopenia. Weare proposing to develop a system to identify small molecular weight compounds which function to increase the ..
  18. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..CD4-leukopenia is considered a risk factor for skin cancer in transplant patients, and at least 23% of transplant patients have ..
  19. Epigenetic control of hematopoietic stem cells
    Christa Muller Sieburg; Fiscal Year: 2007
    ..Relevance: Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells.
  20. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ..This information will provide a framework for rational design of therapies aimed at modulating immune injury and could foster design of preventative measures aimed at immunization. ..
  21. Improving Health Outcomes for Released HIV+ Prisoners
    Frederick Altice; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  22. Directly Observed Therapy for Community-Released HIV-positive Prisoners
    Frederick Altice; Fiscal Year: 2008
    ..It is therefore likely that the stated aim will be successfully accomplished, despite the challenges of working with prisoners and drug-using populations. [unreadable] [unreadable]..
  23. PS06-011, HIV Prevention Research with HIV+ Incarcerated Populations
    Frederick Altice; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  24. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..This information will provide the framework for rational design of new therapies aimed at modulating immune mechanisms and design of preventative measures aimed at immunization. ..
  25. DIRECTLY OBSERVED ANTI RETROVIRAL THERAPY AMONG ACTIVE D
    Frederick Altice; Fiscal Year: 2004
    ..Secondary measures of interest include quality of life measures, health care utilization and entry into drug treatment. ..
  26. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2006
    ..It is expected that Dr. Monk will have obtained extramural funding for both his laboratory and clinical studies by the end of the period of support requested. ..
  27. Predictive Markers of Glioblastoma Response to VEGF Trap
    John de Groot; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Therapy of Temodar plus O6-Benzylguanine in Malignant G*
    Jennifer Quinn; Fiscal Year: 2004
    ..abstract_text> ..
  29. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  30. MARROW REGULATION IN CYCLIC HEMATOPOIESIS
    David Dale; Fiscal Year: 2003
    ....
  31. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  32. Preclinical Testing of Interleukin-7 in Primates
    Jan Storek; Fiscal Year: 2003
    ..These results will be used for the design of clinical studies. ..
  33. Treatment of lung cancer
    Derick Lau; Fiscal Year: 2008
    ..The long-term goal is to develop these peptide ligands as molecularly targeted therapy for lung cancer. 4. To recruit and train hematology and oncology specialists in clinical research of cancer therapy. ..
  34. Progestogen Inhibition of Ovarian Cancer Cell Metastasis
    William Murdoch; Fiscal Year: 2003
    ....
  35. PROTO ONCOGENE PML AND TUMOR EVASION OF HOST IMMUNITY
    Pan Zheng; Fiscal Year: 2002
    ..As such, our study may establish PML as a master regulator controlling MHC class I antigen presentation. ..
  36. Capturing cancer cells with peptide bead technology
    Derick Lau; Fiscal Year: 2003
    ..The development of this technology will greatly enhance our ability of diagnosing malignant pleural effusion, and it will provide a model for capturing and expanding exfoliated malignant cells in other body fluids. ..
  37. T CELL RECONSTITUTION AFTER STEM CELL AUTOGRAFTING
    Jan Storek; Fiscal Year: 2003
    ..This will give impetus for developing strategies to enable older patients to generate T cells from hemopoietic progenitors, e.g., using thymopoietic cytokines or thymus grafting. ..
  38. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
  39. PET IMAGING OF DRUG KINETICS AND PATHWAYS
    Anthony Shields; Fiscal Year: 2002
    ..Our proposed study of [F-18]FAU with PET will provide information on the biodistribution of this new therapeutic agent and may provide a way to image tumor TS activity and proliferation. ..
  40. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  41. THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMA
    Nancy Kemeny; Fiscal Year: 2001
    ..Cryosurgery and newer hepatic arterial therapies are therapeutic modalities that can be used in patients in whom liver resection is impossible. ..
  42. Regulation of the P13K/AKT pathway in Waldenstrom Macroglobulinemia
    Irene Ghobrial; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Plasma Proteome Profiling of Insulin Resistance
    Nana Gletsu Miller; Fiscal Year: 2008
    ..Our proposed proteomics analyses are aimed to fill this critical gap in knowledge. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Labeled Thymidine -- Development as A PET Imaging Agent
    Anthony Shields; Fiscal Year: 2008
    ..Our ultimate goal is to demonstrate that this approach is useful in evaluating both experimental and routine clinical treatment. ..
  45. NIEMANN-PICK DISEASE
    Melissa Wasserstein; Fiscal Year: 2005
    ..In sum, these studies should provide important diagnostic and therapeutic information to improve the outcome of patients diagnosed with NPD. ..
  46. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
    ..We anticipate that these interventions will ultimately enhance the prognosis for patients with relapsed lymphoma by increasing the response and survival rates, while simultaneously minimizing toxicities. ..
  47. ANGIOTENSIN ANALOGS TO TREAT WOUND HEALING
    Kathleen Rodgers; Fiscal Year: 2005
    ..In this phase II SBIR, these compounds will undergo extensive preclinical testing to determine whether they should be further developed as a second generation of wound healing drugs. ..
  48. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..of apoptosis markers whether a relationship exists between modulation of these effects in vitro on tumor cells and a significant antitumor response in vivo in prostate, pancreatic and lung cancer models [unreadable] [unreadable]..
  49. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  50. Language, Literacy, Culture: Communication of Health Concepts
    DOUGLAS BRUGGE; Fiscal Year: 2006
    ....
  51. Regulation of breast cancer growth by activation peptide
    Vaclav Vetvicka; Fiscal Year: 2006
    ..The overall goal is to generate a pharmacological agent for breast cancer based on blockage of the autocrine growth factor activity of pCD. ..
  52. AGT DEPLETION FOR THERAPY OF CNS TUMORS
    Jennifer Quinn; Fiscal Year: 2004
    ..abstract_text> ..
  53. Enhancing the Safety of Research Participants
    Donald Trump; Fiscal Year: 2003
    ..abstract_text> ..
  54. MINORITY BASED COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Peter Wiernik; Fiscal Year: 2006
    ..Efforts in screening and prevention intervention will be facilitated through the Community Outreach program and Community Council. ..
  55. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Insulin resistance in severely obese patients
    Nana Gletsu Miller; Fiscal Year: 2006
    ..Our findings may provide novel mechanisms that link regional obesity and insulin action. ..
  57. NEW APPROACHES TO BRAIN TUMOR THERAPY-(NABTT)
    Henry Brem; Fiscal Year: 2008
    ..abstract_text> ..
  58. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Comorbid Substance Abuse and Long-Term Health Outcomes in Schizophrenia
    DEANNA KELLY; Fiscal Year: 2008
    ..This will be an important step for improving the lives of people with schizophrenia. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..